Table of Contents

Biological Sciences

• Anthropology

  • You have access

    Impetus for sowing and the beginning of agriculture: Ground collecting of wild cereals

    Mordechai E. Kislev, Ehud Weiss, and Anat Hartmann

    PNAS March 2, 2004 101 (9) 2692-2695; https://doi.org/10.1073/pnas.0308739101

• Applied Biological Sciences

  • You have access

    Induction and transmission of Bacillus thuringiensis tolerance in the flour moth Ephestia kuehniella

    M. Mahbubur Rahman, Harry L. S. Roberts, Muhammad Sarjan, Sassan Asgari, and Otto Schmidt

    PNAS March 2, 2004 101 (9) 2696-2699; https://doi.org/10.1073/pnas.0306669101
  • You have access

    Copper-induced ferroportin-1 expression in J774 macrophages is associated with increased iron efflux

    Jayong Chung, David J. Haile, and Marianne Wessling-Resnick

    PNAS March 2, 2004 101 (9) 2700-2705; https://doi.org/10.1073/pnas.0306622101

• Biochemistry

  • You have access

    Structural basis of tyrosine sulfation and V_H-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

    Chih-chin Huang, Miro Venturi, Shahzad Majeed, Michael J. Moore, Sanjay Phogat, Mei-Yun Zhang, Dimiter S. Dimitrov, Wayne A. Hendrickson, James Robinson, Joseph Sodroski, Richard Wyatt, Hyeryun Choe, Michael Farzan, and Peter D. Kwong

    PNAS March 2, 2004 101 (9) 2706-2711; https://doi.org/10.1073/pnas.0308527100
  • You have access

    The solution structure of the N-terminal domain of E3L shows a tyrosine conformation that may explain its reduced affinity to Z-DNA in vitro

    Jan D. Kahmann, Diana A. Wecking, Vera Putter, Ky Lowenhaupt, Yang-Gyun Kim, Peter Schmieder, Hartmut Oschkinat, Alexander Rich, and Markus Schade

    PNAS March 2, 2004 101 (9) 2712-2717; https://doi.org/10.1073/pnas.0308612100
  • You have access

    Crystal structure of the complex between thrombin and the central “E” region of fibrin

    Igor Pechik, Joel Madrazo, Michael W. Mosesson, Irene Hernandez, Gary L. Gilliland, and Leonid Medved

    PNAS March 2, 2004 101 (9) 2718-2723; https://doi.org/10.1073/pnas.0303440101
  • You have access

    Role of interfacial amino acid residues in assembly, stability, and conformation of a spherical virus capsid

    Juan Reguera, Aura Carreira, Laura Riolobos, José María Almendral, and Mauricio G. Mateu

    PNAS March 2, 2004 101 (9) 2724-2729; https://doi.org/10.1073/pnas.0307748101
  • You have access

    Transition state stabilization by general acid catalysis, water expulsion, and enzyme reorganization in Medicago savita chalcone isomerase

    Sun Hur, Zachary E. R. Newby, and Thomas C. Bruice

    PNAS March 2, 2004 101 (9) 2730-2735; https://doi.org/10.1073/pnas.0308264100
  • You have access

    Predicted 3D structure for the human β2 adrenergic receptor and its binding site for agonists and antagonists

    Peter L. Freddolino, M. Yashar S. Kalani, Nagarajan Vaidehi, Wely B. Floriano, Spencer E. Hall, Rene J. Trabanino, Victor Wai Tak Kam, and William A. Goddard III

    PNAS March 2, 2004 101 (9) 2736-2741; https://doi.org/10.1073/pnas.0308751101
  • You have access

    ADP reduces the oxygen-binding affinity of a sensory histidine kinase, FixL: The possibility of an enhanced reciprocating kinase reaction

    Hiro Nakamura, Hideyuki Kumita, Kiyohiro Imai, Tetsutaro Iizuka, and Yoshitsugu Shiro

    PNAS March 2, 2004 101 (9) 2742-2746; https://doi.org/10.1073/pnas.0305795101
  • You have access

    Recycling of a regulatory protein by degradation of the RNA to which it binds

    Gintaras Deikus, Paul Babitzke, and David H. Bechhofer

    PNAS March 2, 2004 101 (9) 2747-2751; https://doi.org/10.1073/pnas.0307343101
  • You have access

    Nuclear localization and molecular partners of BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors

    Philip Ian Padilla, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan

    PNAS March 2, 2004 101 (9) 2752-2757; https://doi.org/10.1073/pnas.0307345101
  • You have access

    Global analysis of Escherichia coli RNA degradosome function using DNA microarrays

    Jonathan A. Bernstein, Pei-Hsun Lin, Stanley N. Cohen, and Sue Lin-Chao

    PNAS March 2, 2004 101 (9) 2758-2763; https://doi.org/10.1073/pnas.0308747101
  • You have access

    Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate

    Zhiquan Zhang, P. T. Ravi Rajagopalan, Tzvia Selzer, Stephen J. Benkovic, and Gordon G. Hammes

    PNAS March 2, 2004 101 (9) 2764-2769; https://doi.org/10.1073/pnas.0400091101
  • You have access

    Two structural features of λ integrase that are critical for DNA cleavage by multimers but not by monomers

    Sang Yeol Lee, Hideki Aihara, Tom Ellenberger, and Arthur Landy

    PNAS March 2, 2004 101 (9) 2770-2775; https://doi.org/10.1073/pnas.0400135101
  • You have access

    Glutamate-183 in the conserved TGES motif of domain A of sarcoplasmic reticulum Ca²⁺-ATPase assists in catalysis of E₂/E₂P partial reactions

    Johannes D. Clausen, Bente Vilsen, David B. McIntosh, Anja P. Einholm, and Jens Peter Andersen

    PNAS March 2, 2004 101 (9) 2776-2781; https://doi.org/10.1073/pnas.0400122101
  • You have access

    Identification of critical residues in GlnB for its activation of NifA activity in the photosynthetic bacterium Rhodospirillum rubrum

    Yaoping Zhang, Edward L. Pohlmann, and Gary P. Roberts

    PNAS March 2, 2004 101 (9) 2782-2787; https://doi.org/10.1073/pnas.0306763101
  • You have access

    Portability and fidelity of RNA-repair systems

    Beate Schwer, Rana Sawaya, C. Kiong Ho, and Stewart Shuman

    PNAS March 2, 2004 101 (9) 2788-2793; https://doi.org/10.1073/pnas.0305859101
  • You have access

    Differential utilization of upstream AUGs in the β-secretase mRNA suggests that a shunting mechanism regulates translation

    George W. Rogers Jr., Gerald M. Edelman, and Vincent P. Mauro

    PNAS March 2, 2004 101 (9) 2794-2799; https://doi.org/10.1073/pnas.0308576101
  • You have access

    Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled γ-phosphate-linked GTP analogs

    Jonas Korlach, Daniel W. Baird, Ahmed A. Heikal, Kyle R. Gee, Gregory R. Hoffman, and Watt W. Webb

    PNAS March 2, 2004 101 (9) 2800-2805; https://doi.org/10.1073/pnas.0308579100
  • You have access

    CIS display: In vitro selection of peptides from libraries of protein–DNA complexes

    Richard Odegrip, David Coomber, Bill Eldridge, Rosemarie Hederer, Philip A. Kuhlman, Christopher Ullman, Kevin FitzGerald, and Duncan McGregor

    PNAS March 2, 2004 101 (9) 2806-2810; https://doi.org/10.1073/pnas.0400219101
  • You have access

    Two discriminatory binding sites in the Escherichia coli replication origin are required for DNA strand opening by initiator DnaA-ATP

    Kevin C. McGarry, Valorie T. Ryan, Julia E. Grimwade, and Alan C. Leonard

    PNAS March 2, 2004 101 (9) 2811-2816; https://doi.org/10.1073/pnas.0400340101
  • You have access

    Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

    Natàlia Reixach, Songpon Deechongkit, Xin Jiang, Jeffery W. Kelly, and Joel N. Buxbaum

    PNAS March 2, 2004 101 (9) 2817-2822; https://doi.org/10.1073/pnas.0400062101
  • You have access

    The nonconserved wrapping of conserved protein folds reveals a trend toward increasing connectivity in proteomic networks

    Ariel Fernández, Ridgway Scott, and R. Stephen Berry

    PNAS March 2, 2004 101 (9) 2823-2827; https://doi.org/10.1073/pnas.0308295100

• Biophysics

  • You have access

    Fluorescence correlation spectroscopy with high-order and dual-color correlation to probe nonequilibrium steady states

    Hong Qian and Elliot L. Elson

    PNAS March 2, 2004 101 (9) 2828-2833; https://doi.org/10.1073/pnas.0305962101
  • You have access

    Solvation in protein folding analysis: Combination of theoretical and experimental approaches

    A. M. Fernández-Escamilla, M. S. Cheung, M. C. Vega, M. Wilmanns, J. N. Onuchic, and L. Serrano

    PNAS March 2, 2004 101 (9) 2834-2839; https://doi.org/10.1073/pnas.0304180101
  • You have access

    The archaeal feast/famine regulatory protein: Potential roles of its assembly forms for regulating transcription

    Hideaki Koike, Sanae A. Ishijima, Lester Clowney, and Masashi Suzuki

    PNAS March 2, 2004 101 (9) 2840-2845; https://doi.org/10.1073/pnas.0400109101
  • You have access

    Imprint of evolution on protein structures

    Guido Tiana, Boris E. Shakhnovich, Nikolay V. Dokholyan, and Eugene I. Shakhnovich

    PNAS March 2, 2004 101 (9) 2846-2851; https://doi.org/10.1073/pnas.0306638101
  • You have access

    Structure of the multidrug resistance efflux transporter EmrE from Escherichia coli

    Che Ma and Geoffrey Chang

    PNAS March 2, 2004 101 (9) 2852-2857; https://doi.org/10.1073/pnas.0400137101
  • You have access

    Determinants of liposome fusion mediated by synaptic SNARE proteins

    Christina G. Schuette, Kiyotaka Hatsuzawa, Martin Margittai, Alexander Stein, Dietmar Riedel, Petra Küster, Marcelle König, Claus Seidel, and Reinhard Jahn

    PNAS March 2, 2004 101 (9) 2858-2863; https://doi.org/10.1073/pnas.0400044101
  • You have access

    Engineering biological structures of prescribed shape using self-assembling multicellular systems

    Karoly Jakab, Adrian Neagu, Vladimir Mironov, Roger R. Markwald, and Gabor Forgacs

    PNAS March 2, 2004 101 (9) 2864-2869; https://doi.org/10.1073/pnas.0400164101

• Cell Biology

  • You have access

    A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway

    Erik Bush, Jens Fielitz, Lawrence Melvin, Michael Martinez-Arnold, Timothy A. McKinsey, Ryan Plichta, and Eric N. Olson

    PNAS March 2, 2004 101 (9) 2870-2875; https://doi.org/10.1073/pnas.0308723101
  • You have access

    Molecular chaperones function as steroid receptor nuclear mobility factors

    Cem Elbi, Dawn A. Walker, Guillermo Romero, William P. Sullivan, David O. Toft, Gordon L. Hager, and Donald B. DeFranco

    PNAS March 2, 2004 101 (9) 2876-2881; https://doi.org/10.1073/pnas.0400116101
  • You have access

    Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of β-catenin

    Feng Cong and Harold Varmus

    PNAS March 2, 2004 101 (9) 2882-2887; https://doi.org/10.1073/pnas.0307344101
  • You have access

    Whole-genome annotation by using evidence integration in functional-linkage networks

    Ulas Karaoz, T. M. Murali, Stan Letovsky, Yu Zheng, Chunming Ding, Charles R. Cantor, and Simon Kasif

    PNAS March 2, 2004 101 (9) 2888-2893; https://doi.org/10.1073/pnas.0307326101
  • You have access

    Disruption of TRPM6/TRPM7 complex formation by a mutation in the TRPM6 gene causes hypomagnesemia with secondary hypocalcemia

    Vladimir Chubanov, Siegfried Waldegger, Michael Mederos y Schnitzler, Helga Vitzthum, Martin C. Sassen, Hannsjörg W. Seyberth, Martin Konrad, and Thomas Gudermann

    PNAS March 2, 2004 101 (9) 2894-2899; https://doi.org/10.1073/pnas.0305252101
  • You have access

    Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling

    Wendy Prudhomme, George Q. Daley, Peter Zandstra, and Douglas A. Lauffenburger

    PNAS March 2, 2004 101 (9) 2900-2905; https://doi.org/10.1073/pnas.0308768101
  • You have access

    Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring

    Wei Yang, Motomu Shimaoka, Azucena Salas, Junichi Takagi, and Timothy A. Springer

    PNAS March 2, 2004 101 (9) 2906-2911; https://doi.org/10.1073/pnas.0307340101
  • You have access

    Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes

    Rabindra Tirouvanziam, Colin J. Davidson, Joseph S. Lipsick, and Leonard A. Herzenberg

    PNAS March 2, 2004 101 (9) 2912-2917; https://doi.org/10.1073/pnas.0308734101
  • You have access

    Transportin2 functions as importin and mediates nuclear import of HuR

    • From the Cover

    Stephan Güttinger, Petra Mühlhäusser, Roland Koller-Eichhorn, Julius Brennecke, and Ulrike Kutay

    PNAS March 2, 2004 101 (9) 2918-2923; https://doi.org/10.1073/pnas.0400342101

• Developmental Biology

  • You have access

    Ghrelin cells replace insulin-producing β cells in two mouse models of pancreas development

    Catherine L. Prado, Aimee E. Pugh-Bernard, Lynda Elghazi, Beatriz Sosa-Pineda, and Lori Sussel

    PNAS March 2, 2004 101 (9) 2924-2929; https://doi.org/10.1073/pnas.0308604100
  • You have access

    The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

    Taka-aki Matsuoka, Isabella Artner, Eva Henderson, Anna Means, Maike Sander, and Roland Stein

    PNAS March 2, 2004 101 (9) 2930-2933; https://doi.org/10.1073/pnas.0306233101

• Ecology

  • You have access

    Transgenic male mating advantage provides opportunity for Trojan gene effect in a fish

    Richard D. Howard, J. Andrew DeWoody, and William M. Muir

    PNAS March 2, 2004 101 (9) 2934-2938; https://doi.org/10.1073/pnas.0306285101

• Evolution

  • You have access

    Imprint of evolution on protein structures

    Guido Tiana, Boris E. Shakhnovich, Nikolay V. Dokholyan, and Eugene I. Shakhnovich

    PNAS March 2, 2004 101 (9) 2846-2851; https://doi.org/10.1073/pnas.0306638101
  • You have access

    Structural and functional divergence of insect CYP6B proteins: From specialist to generalist cytochrome P450

    Xianchun Li, Jerome Baudry, May R. Berenbaum, and Mary A. Schuler

    PNAS March 2, 2004 101 (9) 2939-2944; https://doi.org/10.1073/pnas.0308691101
  • You have access

    Surface hydrocarbons of queen eggs regulate worker reproduction in a social insect

    Annett Endler, Jürgen Liebig, Thomas Schmitt, Jane E. Parker, Graeme R. Jones, Peter Schreier, and Bert Hölldobler

    PNAS March 2, 2004 101 (9) 2945-2950; https://doi.org/10.1073/pnas.0308447101
  • You have access

    Adaptive role of increased frequency of polypurine tracts in mRNA sequences of thermophilic prokaryotes

    Arnon Paz, David Mester, Ivan Baca, Eviatar Nevo, and Abraham Korol

    PNAS March 2, 2004 101 (9) 2951-2956; https://doi.org/10.1073/pnas.0308594100
  • You have access

    Sister grouping of chimpanzees and humans as revealed by genome-wide phylogenetic analysis of brain gene expression profiles

    Monica Uddin, Derek E. Wildman, Guozhen Liu, Wenbo Xu, Robert M. Johnson, Patrick R. Hof, Gregory Kapatos, Lawrence I. Grossman, and Morris Goodman

    PNAS March 2, 2004 101 (9) 2957-2962; https://doi.org/10.1073/pnas.0308725100

• Genetics

  • You have access

    Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene

    Zhipei Liu, Manfred Hergenhahn, Heinz H. Schmeiser, Gerald N. Wogan, Amanda Hong, and Monica Hollstein

    PNAS March 2, 2004 101 (9) 2963-2968; https://doi.org/10.1073/pnas.0308607101
  • You have access

    Intrachromosomal excision of a hybrid Ds element induces large genomic deletions in Arabidopsis

    Damian R. Page, Claudia Köhler, José A. da Costa-Nunes, Célia Baroux, James M. Moore, and Ueli Grossniklaus

    PNAS March 2, 2004 101 (9) 2969-2974; https://doi.org/10.1073/pnas.0400089101
  • You have access

    Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

    Taisuke Hosaka, William H. Biggs III, David Tieu, Antonia D. Boyer, Nissi M. Varki, Webster K. Cavenee, and Karen C. Arden

    PNAS March 2, 2004 101 (9) 2975-2980; https://doi.org/10.1073/pnas.0400093101
  • You have access

    Revealing modularity and organization in the yeast molecular network by integrated analysis of highly heterogeneous genomewide data

    Amos Tanay, Roded Sharan, Martin Kupiec, and Ron Shamir

    PNAS March 2, 2004 101 (9) 2981-2986; https://doi.org/10.1073/pnas.0308661100
  • You have access

    Identification of a target RNA motif for RNA-binding protein HuR

    Isabel López de Silanes, Ming Zhan, Ashish Lal, Xiaoling Yang, and Myriam Gorospe

    PNAS March 2, 2004 101 (9) 2987-2992; https://doi.org/10.1073/pnas.0306453101
  • You have access

    Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect

    Gloria Esposito, Byjay S. Jaiswal, Fang Xie, Magda A. M. Krajnc-Franken, Tamara J. A. A. Robben, Ankie M. Strik, Cor Kuil, Ria L. A. Philipsen, Marcel van Duin, Marco Conti, and Jan A. Gossen

    PNAS March 2, 2004 101 (9) 2993-2998; https://doi.org/10.1073/pnas.0400050101
  • You have access

    Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

    George Adrian Calin, Cinzia Sevignani, Calin Dan Dumitru, Terry Hyslop, Evan Noch, Sai Yendamuri, Masayoshi Shimizu, Sashi Rattan, Florencia Bullrich, Massimo Negrini, and Carlo M. Croce

    PNAS March 2, 2004 101 (9) 2999-3004; https://doi.org/10.1073/pnas.0307323101

• Immunology

  • You have access

    Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFNγ-inducible fibrinogen-like protein 2

    Wayne W. Hancock, Frank M. Szaba, Kiera N. Berggren, Michelle A. Parent, Isis K. Mullarky, John Pearl, Andrea M. Cooper, Kenneth H. Ely, David L. Woodland, In-Jeong Kim, Marcia A. Blackman, Lawrence L. Johnson, and Stephen T. Smiley

    PNAS March 2, 2004 101 (9) 3005-3010; https://doi.org/10.1073/pnas.0308369101
  • You have access

    Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering

    Elena Sandalova, Cheng-Hong Wei, Maria G. Masucci, and Victor Levitsky

    PNAS March 2, 2004 101 (9) 3011-3016; https://doi.org/10.1073/pnas.0400005101
  • You have access

    Early protection against pathogenic virus infection at a mucosal challenge site after vaccination with attenuated simian immunodeficiency virus

    Klara Tenner-Racz, Christiane Stahl Hennig, Klaus Überla, Heribert Stoiber, Ralf Ignatius, Jonathan Heeney, Ralph M. Steinman, and Paul Racz

    PNAS March 2, 2004 101 (9) 3017-3022; https://doi.org/10.1073/pnas.0308677101
  • You have access

    Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation

    Binfeng Lu, Panayiotis Zagouras, James E. Fischer, Junfeng Lu, Baiyong Li, and Richard A. Flavell

    PNAS March 2, 2004 101 (9) 3023-3028; https://doi.org/10.1073/pnas.0307743100
  • You have access

    TLR2 is expressed on activated T cells as a costimulatory receptor

    Mousa Komai-Koma, Louise Jones, Graham S. Ogg, Damo Xu, and Foo Y. Liew

    PNAS March 2, 2004 101 (9) 3029-3034; https://doi.org/10.1073/pnas.0400171101
  • You have access

    Cellular protein is the source of cross-priming antigen in vivo

    Lianjun Shen and Kenneth L. Rock

    PNAS March 2, 2004 101 (9) 3035-3040; https://doi.org/10.1073/pnas.0308345101
  • You have access

    Competition for self-peptide-MHC complexes and cytokines between naïve and memory CD8⁺ T cells expressing the same or different T cell receptors

    Qing Ge, Ailin Bai, Brendan Jones, Herman N. Eisen, and Jianzhu Chen

    PNAS March 2, 2004 101 (9) 3041-3046; https://doi.org/10.1073/pnas.0307339101

• Medical Sciences

  • You have access

    Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis

    Thomas C. Beller, Daniel S. Friend, Akiko Maekawa, Bing K. Lam, K. Frank Austen, and Yoshihide Kanaoka

    PNAS March 2, 2004 101 (9) 3047-3052; https://doi.org/10.1073/pnas.0400235101
  • You have access

    Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics

    Antonis Voutetakis, Marc R. Kok, Changyu Zheng, Ioannis Bossis, Jianghua Wang, Ana P. Cotrim, Natanya Marracino, Corinne M. Goldsmith, John A. Chiorini, Y. Peng Loh, Lynnette K. Nieman, and Bruce J. Baum

    PNAS March 2, 2004 101 (9) 3053-3058; https://doi.org/10.1073/pnas.0400136101
  • You have access

    NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate

    Tapan K. Bera, Sudipto Das, Hiroshi Maeda, Richard Beers, Curt D. Wolfgang, Vasantha Kumar, Yoonsoo Hahn, Byungkook Lee, and Ira Pastan

    PNAS March 2, 2004 101 (9) 3059-3064; https://doi.org/10.1073/pnas.0308746101
  • You have access

    Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease

    Cristina Casalone, Gianluigi Zanusso, Pierluigi Acutis, Sergio Ferrari, Lorenzo Capucci, Fabrizio Tagliavini, Salvatore Monaco, and Maria Caramelli

    PNAS March 2, 2004 101 (9) 3065-3070; https://doi.org/10.1073/pnas.0305777101
  • You have access

    Minocycline inhibits contusion-triggered mitochondrial cytochrome c release and mitigates functional deficits after spinal cord injury

    Yang D. Teng, Howard Choi, Renna C. Onario, Shan Zhu, Federico C. Desilets, Shoumin Lan, Eric J. Woodard, Evan Y. Snyder, Marc E. Eichler, and Robert M. Friedlander

    PNAS March 2, 2004 101 (9) 3071-3076; https://doi.org/10.1073/pnas.0306239101
  • You have access

    The SPANX gene family of cancer/testis-specific antigens: Rapid evolution and amplification in African great apes and hominids

    Natalay Kouprina, Michael Mullokandov, Igor B. Rogozin, N. Keith Collins, Greg Solomon, John Otstot, John I. Risinger, Eugene V. Koonin, J. Carl Barrett, and Vladimir Larionov

    PNAS March 2, 2004 101 (9) 3077-3082; https://doi.org/10.1073/pnas.0308532100
  • You have access

    Glycosylation-independent targeting enhances enzyme delivery to lysosomes and decreases storage in mucopolysaccharidosis type VII mice

    Jonathan H. LeBowitz, Jeffrey H. Grubb, John A. Maga, Deborah H. Schmiel, Carole Vogler, and William S. Sly

    PNAS March 2, 2004 101 (9) 3083-3088; https://doi.org/10.1073/pnas.0308728100
  • You have access

    Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

    Tian-Li Wang, Luis A. Diaz Jr., Katharine Romans, Alberto Bardelli, Saurabh Saha, Gennaro Galizia, Michael Choti, Ross Donehower, Giovanni Parmigiani, Ie-Ming Shih, Christine Iacobuzio-Donahue, Kenneth W. Kinzler, Bert Vogelstein, Christoph Lengauer, and Victor E. Velculescu

    PNAS March 2, 2004 101 (9) 3089-3094; https://doi.org/10.1073/pnas.0308716101
  • You have access

    Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab

    Subhash C. Sinha, Lian-Sheng Li, Gregory P. Miller, Shantanu Dutta, Christoph Rader, and Richard A. Lerner

    PNAS March 2, 2004 101 (9) 3095-3099; https://doi.org/10.1073/pnas.0307319101
  • You have access

    Role for neuronal insulin resistance in neurodegenerative diseases

    Markus Schubert, Dinesh Gautam, David Surjo, Kojihiko Ueki, Stephanie Baudler, Dominic Schubert, Tatsuya Kondo, Jens Alber, Norbert Galldiks, Eckehardt Küstermann, Saskia Arndt, Andreas H. Jacobs, Wilhelm Krone, C. Ronald Kahn, and Jens C. Brüning

    PNAS March 2, 2004 101 (9) 3100-3105; https://doi.org/10.1073/pnas.0308724101
  • You have access

    Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene

    Kathleen M. I. Caron, Leighton R. James, Hyung-Suk Kim, Josh Knowles, Rick Uhlir, Lan Mao, John R. Hagaman, Wayne Cascio, Howard Rockman, and Oliver Smithies

    PNAS March 2, 2004 101 (9) 3106-3111; https://doi.org/10.1073/pnas.0307333101
  • You have access

    The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

    Jianchao Xu, Peili Wang, Yanyan Li, Guoyong Li, Leonard K. Kaczmarek, Yanling Wu, Pandelakis A. Koni, Richard A. Flavell, and Gary V. Desir

    PNAS March 2, 2004 101 (9) 3112-3117; https://doi.org/10.1073/pnas.0308450100
  • You have access

    Activation of the Wnt signaling pathway in chronic lymphocytic leukemia

    Desheng Lu, Yandong Zhao, Rommel Tawatao, Howard B. Cottam, Malini Sen, Lorenzo M. Leoni, Thomas J. Kipps, Maripat Corr, and Dennis A. Carson

    PNAS March 2, 2004 101 (9) 3118-3123; https://doi.org/10.1073/pnas.0308648100
  • You have access

    E1A and E1B proteins inhibit inflammation induced by adenovirus

    Jerome Schaack, Michael L. Bennett, Jeff D. Colbert, Andres Vazquez Torres, Gerald H. Clayton, David Ornelles, and John Moorhead

    PNAS March 2, 2004 101 (9) 3124-3129; https://doi.org/10.1073/pnas.0303709101
  • You have access

    Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

    M. Golam Mohi, Christina Boulton, Ting-Lei Gu, David W. Sternberg, Donna Neuberg, James D. Griffin, D. Gary Gilliland, and Benjamin G. Neel

    PNAS March 2, 2004 101 (9) 3130-3135; https://doi.org/10.1073/pnas.0400063101
  • You have access

    A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

    Anna Hansson, Nicole Hance, Eric Dufour, Anja Rantanen, Kjell Hultenby, David A. Clayton, Rolf Wibom, and Nils-Göran Larsson

    PNAS March 2, 2004 101 (9) 3136-3141; https://doi.org/10.1073/pnas.0308710100

• Microbiology

  • You have access

    Outer-surface protein C of the Lyme disease spirochete: A protein induced in ticks for infection of mammals

    Dorothee Grimm, Kit Tilly, Rebecca Byram, Philip E. Stewart, Jonathan G. Krum, Dawn M. Bueschel, Tom G. Schwan, Paul F. Policastro, Abdallah F. Elias, and Patricia A. Rosa

    PNAS March 2, 2004 101 (9) 3142-3147; https://doi.org/10.1073/pnas.0306845101
  • You have access

    Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation

    Jian Wu, Nianshu Zhang, Andrew Hayes, Kalliope Panoutsopoulou, and Stephen G. Oliver

    PNAS March 2, 2004 101 (9) 3148-3153; https://doi.org/10.1073/pnas.0308321100
  • You have access

    Gene transfer in the evolution of parasite nucleotide biosynthesis

    Boris Striepen, Andrea J. P. Pruijssers, Jinling Huang, Catherine Li, Marc-Jan Gubbels, Nwakaso N. Umejiego, Lizbeth Hedstrom, and Jessica C. Kissinger

    PNAS March 2, 2004 101 (9) 3154-3159; https://doi.org/10.1073/pnas.0304686101
  • You have access

    Trends between gene content and genome size in prokaryotic species with larger genomes

    Konstantinos T. Konstantinidis and James M. Tiedje

    PNAS March 2, 2004 101 (9) 3160-3165; https://doi.org/10.1073/pnas.0308653100
  • You have access

    Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus

    Terrence M. Tumpey, Adolfo García-Sastre, Jeffery K. Taubenberger, Peter Palese, David E. Swayne, and Christopher F. Basler

    PNAS March 2, 2004 101 (9) 3166-3171; https://doi.org/10.1073/pnas.0308391100

• Neuroscience

  • You have access

    Astrocyte-mediated activation of neuronal kainate receptors

    • From the Cover

    Qing-song Liu, Qiwu Xu, Gregory Arcuino, Jian Kang, and Maiken Nedergaard

    PNAS March 2, 2004 101 (9) 3172-3177; https://doi.org/10.1073/pnas.0306731101

    See companion article:

    • When astrocytes signal, kainate receptors respond

      - Feb 23, 2004
  • You have access

    RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells

    Michele M. Maxwell, Piera Pasinelli, Aleksey G. Kazantsev, and Robert H. Brown Jr.

    PNAS March 2, 2004 101 (9) 3178-3183; https://doi.org/10.1073/pnas.0308726100
  • You have access

    Categorization in the monkey hippocampus: A possible mechanism for encoding information into memory

    Robert E. Hampson, Tim P. Pons, Terrence R. Stanford, and Sam A. Deadwyler

    PNAS March 2, 2004 101 (9) 3184-3189; https://doi.org/10.1073/pnas.0400162101
  • You have access

    Clathrin-mediated endocytosis is required for compensatory regulation of GLR-1 glutamate receptors after activity blockade

    Maria E. Grunwald, Jerry E. Mellem, Nathalie Strutz, Andres V. Maricq, and Joshua M. Kaplan

    PNAS March 2, 2004 101 (9) 3190-3195; https://doi.org/10.1073/pnas.0306156101
  • You have access

    Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: A major site of neurogenesis

    • From the Cover

    Wulf Haubensak, Alessio Attardo, Winfried Denk, and Wieland B. Huttner

    PNAS March 2, 2004 101 (9) 3196-3201; https://doi.org/10.1073/pnas.0308600100
  • You have access

    Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex

    Masatoshi Suzuki, Lynda S. Wright, Padma Marwah, Henry A. Lardy, and Clive N. Svendsen

    PNAS March 2, 2004 101 (9) 3202-3207; https://doi.org/10.1073/pnas.0307325101
  • You have access

    Plasma membrane localization signals in the light chain of botulinum neurotoxin

    Ester Fernández-Salas, Lance E. Steward, Helen Ho, Patton E. Garay, Sarah W. Sun, Marcella A. Gilmore, Joseph V. Ordas, Joanne Wang, Joseph Francis, and K. Roger Aoki

    PNAS March 2, 2004 101 (9) 3208-3213; https://doi.org/10.1073/pnas.0400229101
  • You have access

    P2X₇ receptors control 2-arachidonoylglycerol production by microglial cells

    Anke Witting, Lisa Walter, Jennifer Wacker, Thomas Möller, and Nephi Stella

    PNAS March 2, 2004 101 (9) 3214-3219; https://doi.org/10.1073/pnas.0306707101
  • You have access

    Expression of functional receptors by the human γ-aminobutyric acid A γ2 subunit

    Ataúlfo Martínez-Torres and Ricardo Miledi

    PNAS March 2, 2004 101 (9) 3220-3223; https://doi.org/10.1073/pnas.0308682101
  • You have access

    Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease

    Wyan-Ching Mimi Lee, Motojiro Yoshihara, and J. Troy Littleton

    PNAS March 2, 2004 101 (9) 3224-3229; https://doi.org/10.1073/pnas.0400243101
  • You have access

    Correspondence of presaccadic activity in the monkey primary visual cortex with saccadic eye movements

    Hans Supèr, Chris van der Togt, Henk Spekreijse, and Victor A. F. Lamme

    PNAS March 2, 2004 101 (9) 3230-3235; https://doi.org/10.1073/pnas.0400433101
  • You have access

    Genetic evidence for the bidirectional modulation of synaptic plasticity in the prefrontal cortex by D1 receptors

    Yan-You Huang, Eleanor Simpson, Christoph Kellendonk, and Eric R. Kandel

    PNAS March 2, 2004 101 (9) 3236-3241; https://doi.org/10.1073/pnas.0308280101

• Pharmacology

  • You have access

    Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection

    Yuequan Shen, Natalia L. Zhukovskaya, Michael I. Zimmer, Sandriyana Soelaiman, Pamela Bergson, Chyung-Ru Wang, Craig S. Gibbs, and Wei-Jen Tang

    PNAS March 2, 2004 101 (9) 3242-3247; https://doi.org/10.1073/pnas.0306552101
  • You have access

    K channel gating by an affinity-switching selectivity filter

    Antonius M. J. VanDongen

    PNAS March 2, 2004 101 (9) 3248-3252; https://doi.org/10.1073/pnas.0308743101
  • You have access

    Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I

    Irmgard Tegeder, Domenico Del Turco, Achim Schmidtko, Matthias Sausbier, Robert Feil, Franz Hofmann, Thomas Deller, Peter Ruth, and Gerd Geisslinger

    PNAS March 2, 2004 101 (9) 3253-3257; https://doi.org/10.1073/pnas.0304076101

• Physiology

  • You have access

    Serum leptin level is a regulator of bone mass

    F. Elefteriou, S. Takeda, K. Ebihara, J. Magre, N. Patano, C. Ae Kim, Y. Ogawa, X. Liu, S. M. Ware, W. J. Craigen, J. J. Robert, C. Vinson, K. Nakao, J. Capeau, and G. Karsenty

    PNAS March 2, 2004 101 (9) 3258-3263; https://doi.org/10.1073/pnas.0308744101
  • You have access

    Alcohol inhibits luteinizing hormone-releasing hormone release by activating the endocannabinoid system

    Javier Fernández-Solari, Camila Scorticati, Claudia Mohn, Andrea De Laurentiis, Silvia Billi, Ana Franchi, Samuel M. McCann, and Valeria Rettori

    PNAS March 2, 2004 101 (9) 3264-3268; https://doi.org/10.1073/pnas.0307346101

• Plant Biology

  • You have access

    Pseudomonas syringae pv. tomato cells encounter inhibitory levels of water stress during the hypersensitive response of Arabidopsis thaliana

    Catherine A. Wright and Gwyn A. Beattie

    PNAS March 2, 2004 101 (9) 3269-3274; https://doi.org/10.1073/pnas.0400461101
  • You have access

    On the role of RNA silencing in the pathogenicity and evolution of viroids and viral satellites

    Ming-Bo Wang, Xue-Yu Bian, Li-Min Wu, Li-Xia Liu, Neil A. Smith, Daniel Isenegger, Rong-Mei Wu, Chikara Masuta, Vicki B. Vance, John M. Watson, Ali Rezaian, Elizabeth S. Dennis, and Peter M. Waterhouse

    PNAS March 2, 2004 101 (9) 3275-3280; https://doi.org/10.1073/pnas.0400104101
  • You have access

    FRIGIDA-related genes are required for the winter-annual habit in Arabidopsis

    Scott D. Michaels, Isabel C. Bezerra, and Richard M. Amasino

    PNAS March 2, 2004 101 (9) 3281-3285; https://doi.org/10.1073/pnas.0306778101
  • You have access

    Comparisons of pollen coat genes across Brassicaceae species reveal rapid evolution by repeat expansion and diversification

    Aretha Fiebig, Rebecca Kimport, and Daphne Preuss

    PNAS March 2, 2004 101 (9) 3286-3291; https://doi.org/10.1073/pnas.0305448101
  • You have access

    CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis

    Xavier Daniel, Shoji Sugano, and Elaine M. Tobin

    PNAS March 2, 2004 101 (9) 3292-3297; https://doi.org/10.1073/pnas.0400163101
  • You have access

    Expression of an active tobacco mitogen-activated protein kinase kinase kinase enhances freezing tolerance in transgenic maize

    • From the Cover

    Huixia Shou, Patricia Bordallo, Jian-Bing Fan, Joanne M. Yeakley, Marina Bibikova, Jen Sheen, and Kan Wang

    PNAS March 2, 2004 101 (9) 3298-3303; https://doi.org/10.1073/pnas.0308095100
  • You have access

    Blue light-induced transcription of plastid-encoded psbD gene is mediated by a nuclear-encoded transcription initiation factor, AtSig5

    Yuichi Tsunoyama, Yoko Ishizaki, Kazuya Morikawa, Maki Kobori, Yoichi Nakahira, Go Takeba, Yoshinori Toyoshima, and Takashi Shiina

    PNAS March 2, 2004 101 (9) 3304-3309; https://doi.org/10.1073/pnas.0308362101

• Psychology

  • You have access

    Two routes to emotional memory: Distinct neural processes for valence and arousal

    Elizabeth A. Kensinger and Suzanne Corkin

    PNAS March 2, 2004 101 (9) 3310-3315; https://doi.org/10.1073/pnas.0306408101