ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines

^*Department of Systems Biology, Harvard Medical School, Boston, MA 02115; ^†Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215; ^‡Department of Medical Oncology, Dana–Farber Cancer Institute, and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115; and ^§Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

Contributed by Lewis C. Cantley, December 27, 2004

Footnotes

↵ ¶ To whom correspondence should be addressed at: Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Room 1022, Boston, MA 02115. E-mail: lewis_cantley{at}hms.harvard.edu.
Author contributions: J.A.E., P.A.J., and L.C.C. designed research; J.A.E., C.M., T.M., and C.F. performed research; J.A.E., P.A.J., J.P., K.C. and B.E.J. contributed new reagents/analytic tools; J.A.E., P.A.J., B.E.J., and L.C.C. analyzed data; and J.A.E. and L.C.C. wrote the paper.
Abbreviations: EGFR, EGF receptor; NSCLC, non-small cell lung cancer; PI3K, phosphoinositide 3-kinase; shRNA, short hairpin RNA; TKI, tyrosine kinase inhibitor; IPs, immunoprecipitates; PTyr, phosphotyrosine.

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Jul 2005	31	149	97
Aug 2005	39	146	103
Sep 2005	25	135	105
Oct 2005	20	129	93
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Dec 2005	25	94	67
Total 2005	1122	1912	1958
Jan 2006	16	105	79
Feb 2006	29	105	56
Mar 2006	18	141	77
Apr 2006	18	104	65
May 2006	22	101	79
Jun 2006	19	80	64
Jul 2006	13	93	62
Aug 2006	20	71	52
Sep 2006	25	42	45
Oct 2006	47	72	56
Nov 2006	39	64	52
Dec 2006	24	47	36
Total 2006	290	1025	723
Jan 2007	31	88	75
Feb 2007	13	67	52
Mar 2007	33	47	41
Apr 2007	42	66	61
May 2007	55	95	66
Jun 2007	27	75	68
Jul 2007	22	52	44
Aug 2007	22	52	52
Sep 2007	25	53	57
Oct 2007	34	52	58
Nov 2007	16	45	45
Dec 2007	16	39	54
Total 2007	336	731	673
Jan 2008	20	51	51
Feb 2008	20	38	50
Mar 2008	42	55	59
Apr 2008	35	48	50
May 2008	26	79	54
Jun 2008	30	64	53
Jul 2008	79	29	46
Aug 2008	98	36	47
Sep 2008	106	25	46
Oct 2008	64	30	50
Nov 2008	114	40	53
Dec 2008	60	27	33
Total 2008	694	522	592
Jan 2009	74	30	39
Feb 2009	47	22	27
Mar 2009	35	48	34
Apr 2009	28	41	17
May 2009	45	41	30
Jun 2009	38	41	34
Jul 2009	33	51	43
Aug 2009	25	62	36
Sep 2009	37	66	41
Oct 2009	51	39	45
Nov 2009	54	49	43
Dec 2009	54	41	52
Total 2009	521	531	441
Jan 2010	45	47	30
Feb 2010	51	68	51
Mar 2010	32	66	43
Apr 2010	64	40	33
May 2010	40	60	44
Jun 2010	38	35	32
Jul 2010	40	30	44
Aug 2010	48	39	34
Sep 2010	62	44	56
Oct 2010	42	31	33
Nov 2010	45	39	32
Dec 2010	35	20	28
Total 2010	542	519	460
Jan 2011	28	33	32
Feb 2011	52	27	26
Mar 2011	29	34	28
Apr 2011	41	41	34
May 2011	43	34	41
Jun 2011	37	22	28
Jul 2011	59	31	36
Aug 2011	64	26	32
Sep 2011	39	37	33
Oct 2011	51	39	29
Nov 2011	43	53	37
Dec 2011	32	30	28
Total 2011	518	407	384
Jan 2012	29	34	29
Feb 2012	33	37	28
Mar 2012	36	45	40
Apr 2012	40	52	48
May 2012	44	27	31
Jun 2012	35	38	21
Jul 2012	32	37	26
Aug 2012	18	15	16
Sep 2012	36	35	31
Oct 2012	40	28	37
Nov 2012	33	25	34
Dec 2012	34	22	18
Total 2012	410	395	359
Jan 2013	27	27	34
Feb 2013	36	31	24
Mar 2013	38	24	28
Apr 2013	38	18	34
May 2013	32	20	32
Jun 2013	32	27	27
Jul 2013	54	30	30
Aug 2013	28	23	28
Sep 2013	27	27	15
Oct 2013	29	39	20
Nov 2013	25	17	19
Dec 2013	33	23	15
Total 2013	399	306	306
Jan 2014	37	33	21
Feb 2014	34	23	12
Mar 2014	22	19	12
Apr 2014	58	31	27
May 2014	40	32	21
Jun 2014	51	19	17
Jul 2014	43	21	19
Aug 2014	29	25	16
Sep 2014	33	15	24
Oct 2014	53	47	31
Nov 2014	39	27	26
Dec 2014	47	38	20
Total 2014	486	330	246
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Feb 2015	43	26	17
Mar 2015	37	17	69
Apr 2015	40	31	33
May 2015	24	14	13
Jun 2015	30	19	25
Jul 2015	20	22	18
Aug 2015	14	18	30
Sep 2015	74	18	29
Oct 2015	39	24	26
Nov 2015	17	12	30
Dec 2015	31	13	23
Total 2015	410	241	339
Jan 2016	26	16	26
Feb 2016	21	23	25
Mar 2016	28	21	16
Apr 2016	16	26	18
May 2016	19	28	19
Jun 2016	25	11	14
Jul 2016	36	24	25
Aug 2016	38	15	13
Sep 2016	52	12	20
Oct 2016	36	12	17
Nov 2016	44	26	14
Dec 2016	37	15	9
Total 2016	378	229	216
Jan 2017	44	25	24
Feb 2017	14	18	13
Mar 2017	61	29	24
Apr 2017	24	7	8
May 2017	48	19	15
Jun 2017	22	25	13
Jul 2017	26	19	17
Aug 2017	30	37	25
Sep 2017	22	13	14
Oct 2017	32	19	22
Nov 2017	33	20	14
Dec 2017	22	208	10
Total 2017	378	439	199
Jan 2018	49	30	10
Feb 2018	41	31	19
Mar 2018	41	44	19
Apr 2018	45	42	15
May 2018	24	24	13
Jun 2018	32	28	10
Jul 2018	39	37	16
Aug 2018	60	61	9
Sep 2018	58	52	14
Oct 2018	9	34	15
Nov 2018	7	69	18
Dec 2018	8	37	16
Total 2018	413	489	174
Jan 2019	5	29	9
Feb 2019	0	23	7
Mar 2019	12	54	20
Apr 2019	5	57	20
May 2019	13	36	13
Jun 2019	7	39	11
Jul 2019	3	23	10
Total 2019	45	261	90
Total	6942	8337	7160