Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation

    Benjamin G. Keselowsky, David M. Collard, and Andrés J. García

    PNAS April 26, 2005 102 (17) 5953-5957; https://doi.org/10.1073/pnas.0407356102

• Biochemistry

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    A mutation in T7 RNA polymerase that facilitates promoter clearance

    Jean Guillerez, Pascal J. Lopez, Florence Proux, Hélène Launay, and Marc Dreyfus

    PNAS April 26, 2005 102 (17) 5958-5963; https://doi.org/10.1073/pnas.0407141102

    See companion article:

    • In This Issue

      - Aug 15, 2011
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    The human Kv1.1 channel is palmitoylated, modulating voltage sensing: Identification of a palmitoylation consensus sequence

    Rose A. Gubitosi-Klug, David J. Mancuso, and Richard W. Gross

    PNAS April 26, 2005 102 (17) 5964-5968; https://doi.org/10.1073/pnas.0501999102
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    Scanning the human proteome for calmodulin-binding proteins

    Xinchun Shen, C. Alexander Valencia, Jack Szostak, Biao Dong, and Rihe Liu

    PNAS April 26, 2005 102 (17) 5969-5974; https://doi.org/10.1073/pnas.0407928102
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    Structural basis for the interaction of Asf1 with histone H3 and its functional implications

    Florence Mousson, Aurélie Lautrette, Jean-Yves Thuret, Morgane Agez, Régis Courbeyrette, Béatrice Amigues, Emmanuelle Becker, Jean-Michel Neumann, Raphaël Guerois, Carl Mann, and Françoise Ochsenbein

    PNAS April 26, 2005 102 (17) 5975-5980; https://doi.org/10.1073/pnas.0500149102
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    Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase

    Mindy I. Davis, Melanie J. Bennett, Leonard M. Thomas, and Pamela J. Bjorkman

    PNAS April 26, 2005 102 (17) 5981-5986; https://doi.org/10.1073/pnas.0502101102
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    Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion

    Anne-Laure Bulteau, Kathleen C. Lundberg, Masao Ikeda-Saito, Grazia Isaya, and Luke I. Szweda

    PNAS April 26, 2005 102 (17) 5987-5991; https://doi.org/10.1073/pnas.0501519102
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    Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

    Arvind Ramanathan, Connie Wang, and Stuart L. Schreiber

    PNAS April 26, 2005 102 (17) 5992-5997; https://doi.org/10.1073/pnas.0502267102
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    Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells

    Sangkil Nam, Ralf Buettner, James Turkson, Donghwa Kim, Jin Q. Cheng, Stephan Muehlbeyer, Frankie Hippe, Sandra Vatter, Karl-Heinz Merz, Gerhard Eisenbrand, and Richard Jove

    PNAS April 26, 2005 102 (17) 5998-6003; https://doi.org/10.1073/pnas.0409467102

• Biophysics

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    Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose

    M. G. Sacerdote and J. W. Szostak

    PNAS April 26, 2005 102 (17) 6004-6008; https://doi.org/10.1073/pnas.0408440102
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    Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors

    • From the Cover

    Anna Codina, James D. Love, Yun Li, Mitchell A. Lazar, David Neuhaus, and John W. R. Schwabe

    PNAS April 26, 2005 102 (17) 6009-6014; https://doi.org/10.1073/pnas.0500299102
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    Folding events in the 21-30 region of amyloid β-protein (Aβ) studied in silico

    Jose M. Borreguero, Brigita Urbanc, Noel D. Lazo, Sergey V. Buldyrev, David B. Teplow, and H. Eugene Stanley

    PNAS April 26, 2005 102 (17) 6015-6020; https://doi.org/10.1073/pnas.0502006102

• Cell Biology

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    Implications of the serine protease HtrA1 in amyloid precursor protein processing

    Sandra Grau, Alfonso Baldi, Rossana Bussani, Xiaodan Tian, Raluca Stefanescu, Michael Przybylski, Peter Richards, Simon A. Jones, Viji Shridhar, Tim Clausen, and Michael Ehrmann

    PNAS April 26, 2005 102 (17) 6021-6026; https://doi.org/10.1073/pnas.0501823102
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    G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the β-catenin pathway

    Ming Yang, Wendy W. Zhong, Neelam Srivastava, Anthony Slavin, Jianxin Yang, Timothy Hoey, and Songzhu An

    PNAS April 26, 2005 102 (17) 6027-6032; https://doi.org/10.1073/pnas.0501535102

• Ecology

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    Ecological controls on water-cycle response to climate variability in deserts

    B. R. Scanlon, D. G. Levitt, R. C. Reedy, K. E. Keese, and M. J. Sully

    PNAS April 26, 2005 102 (17) 6033-6038; https://doi.org/10.1073/pnas.0408571102

• Evolution

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    Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods

    • From the Cover

    Yoshihito Niimura and Masatoshi Nei

    PNAS April 26, 2005 102 (17) 6039-6044; https://doi.org/10.1073/pnas.0501922102
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    Genetic variance in female condition predicts indirect genetic variance in male sexual display traits

    Donna Petfield, Stephen F. Chenoweth, Howard D. Rundle, and Mark W. Blows

    PNAS April 26, 2005 102 (17) 6045-6050; https://doi.org/10.1073/pnas.0409378102

• Genetics

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    Analysis of mouse embryonic patterning and morphogenesis by forward genetics

    • Inaugural Article

    María J. García-García, Jonathan T. Eggenschwiler, Tamara Caspary, Heather L. Alcorn, Michael R. Wyler, Danwei Huangfu, Andrew S. Rakeman, Jeffrey D. Lee, Evan H. Feinberg, John R. Timmer, and Kathryn V. Anderson

    PNAS April 26, 2005 102 (17) 5913-5919; https://doi.org/10.1073/pnas.0501071102

    See companion article:

    • Biography of Kathryn V. Anderson

      - Apr 19, 2005
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    Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia

    Anne Goriely, Gilean A. T. McVean, Ans M. M. van Pelt, Anthony W. O'Rourke, Steven A. Wall, Dirk G. de Rooij, and Andrew O. M. Wilkie

    PNAS April 26, 2005 102 (17) 6051-6056; https://doi.org/10.1073/pnas.0500267102
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    Rare creation of recombinant mtDNA haplotypes in mammalian tissues

    Akitsugu Sato, Kazuto Nakada, Miho Akimoto, Kaori Ishikawa, Tomoko Ono, Hiroshi Shitara, Hiromichi Yonekawa, and Jun-Ichi Hayashi

    PNAS April 26, 2005 102 (17) 6057-6062; https://doi.org/10.1073/pnas.0408666102
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    Germ cell mutagenesis in medaka fish after exposures to high-energy cosmic ray nuclei: A human model

    Atsuko Shimada, Akihiro Shima, Kumie Nojima, Yo Seino, and Richard B. Setlow

    PNAS April 26, 2005 102 (17) 6063-6067; https://doi.org/10.1073/pnas.0500895102

• Immunology

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    Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia

    David M. Langenau, Hui Feng, Stephane Berghmans, John P. Kanki, Jeffery L. Kutok, and A. Thomas Look

    PNAS April 26, 2005 102 (17) 6068-6073; https://doi.org/10.1073/pnas.0408708102
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    Effector CD8⁺ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression

    Dana R. Marshall, Elvia Olivas, Samita Andreansky, Nicole L. La Gruta, Geoff A. Neale, Astrid Gutierrez, David G. Wichlan, Suzette Wingo, Cheng Cheng, Peter C. Doherty, and Stephen J. Turner

    PNAS April 26, 2005 102 (17) 6074-6079; https://doi.org/10.1073/pnas.0501960102

• Medical Sciences

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    Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy

    Lingfei Xu, Timothy C. Nichols, Rita Sarkar, Stephanie McCorquodale, Dwight A. Bellinger, and Katherine P. Ponder

    PNAS April 26, 2005 102 (17) 6080-6085; https://doi.org/10.1073/pnas.0409249102
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    Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice

    Aimin Xu, Michael C. Lam, Kok Weng Chan, Yu Wang, Jialiang Zhang, Ruby L. C. Hoo, Jian Yu Xu, Baoying Chen, Wing-Sun Chow, Annette W. K. Tso, and Karen S. L. Lam

    PNAS April 26, 2005 102 (17) 6086-6091; https://doi.org/10.1073/pnas.0408452102
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    The gene expression signatures of melanoma progression

    • From the Cover

    Christopher Haqq, Mehdi Nosrati, Daniel Sudilovsky, Julia Crothers, Daniel Khodabakhsh, Brian L. Pulliam, Scot Federman, James R. Miller III, Robert E. Allen, Mark I. Singer, Stanley P. L. Leong, Britt-Marie Ljung, Richard W. Sagebiel, and Mohammed Kashani-Sabet

    PNAS April 26, 2005 102 (17) 6092-6097; https://doi.org/10.1073/pnas.0501564102

    See companion article:

    • In This Issue

      - Aug 15, 2011
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    Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism

    Katarzyna Lundmark, Gunilla T. Westermark, Arne Olsén, and Per Westermark

    PNAS April 26, 2005 102 (17) 6098-6102; https://doi.org/10.1073/pnas.0501814102

• Microbiology

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    Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites

    Alexander G. Holman and John M. Coffin

    PNAS April 26, 2005 102 (17) 6103-6107; https://doi.org/10.1073/pnas.0501646102

    See companion article:

    • Symmetrical recognition of cellular DNA target sequences during retroviral integration

      - Apr 19, 2005
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    Direct activation of fission yeast adenylate cyclase by the Gpa2 Gα of the glucose signaling pathway

    F. Douglas Ivey and Charles S. Hoffman

    PNAS April 26, 2005 102 (17) 6108-6113; https://doi.org/10.1073/pnas.0502270102
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    A polymerization-depolymerization model that accurately generates the self-sustained oscillatory system involved in bacterial division site placement

    Donald A. Drew, Mary J. Osborn, and Lawrence I. Rothfield

    PNAS April 26, 2005 102 (17) 6114-6118; https://doi.org/10.1073/pnas.0502037102
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    Self-limiting nature of seasonal cholera epidemics: Role of host-mediated amplification of phage

    Shah M. Faruque, M. Johirul Islam, Qazi Shafi Ahmad, A. S. G. Faruque, David A. Sack, G. Balakrish Nair, and John J. Mekalanos

    PNAS April 26, 2005 102 (17) 6119-6124; https://doi.org/10.1073/pnas.0502069102

• Neuroscience

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    Identification of network-level coding units for real-time representation of episodic experiences in the hippocampus

    Longnian Lin, Remus Osan, Shy Shoham, Wenjun Jin, Wenqi Zuo, and Joe Z. Tsien

    PNAS April 26, 2005 102 (17) 6125-6130; https://doi.org/10.1073/pnas.0408233102

    See companion article:

    • In This Issue

      - Aug 15, 2011
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    Synaptic vesicle recycling studied in transgenic mice expressing synaptopHluorin

    • From the Cover

    Zhiying Li, Juan Burrone, William J. Tyler, Kenichi N. Hartman, Dinu F. Albeanu, and Venkatesh N. Murthy

    PNAS April 26, 2005 102 (17) 6131-6136; https://doi.org/10.1073/pnas.0501145102

    See companion article:

    • Vesicle reuse revisited

      - May 17, 2005
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    Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter

    Christine I. Nam and Lu Chen

    PNAS April 26, 2005 102 (17) 6137-6142; https://doi.org/10.1073/pnas.0502038102
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    Aneuploid neurons are functionally active and integrated into brain circuitry

    M. A. Kingsbury, B. Friedman, M. J. McConnell, S. K. Rehen, A. H. Yang, D. Kaushal, and J. Chun

    PNAS April 26, 2005 102 (17) 6143-6147; https://doi.org/10.1073/pnas.0408171102
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    Neuronal migration in the murine rostral migratory stream requires serum response factor

    Siegfried Alberti, Sven M. Krause, Oliver Kretz, Ulrike Philippar, Thomas Lemberger, Emilio Casanova, Franziska F. Wiebel, Heinz Schwarz, Michael Frotscher, Günther Schütz, and Alfred Nordheim

    PNAS April 26, 2005 102 (17) 6148-6153; https://doi.org/10.1073/pnas.0501191102
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    Zinc inhibition of γ-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission

    Einav Cohen-Kfir, William Lee, Sepehr Eskandari, and Nathan Nelson

    PNAS April 26, 2005 102 (17) 6154-6159; https://doi.org/10.1073/pnas.0501431102
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    Fluorescence measurements reveal stoichiometry of K⁺ channels formed by modulatory and delayed rectifier α-subunits

    Daniel Kerschensteiner, Florentina Soto, and Martin Stocker

    PNAS April 26, 2005 102 (17) 6160-6165; https://doi.org/10.1073/pnas.0500468102
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    Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures

    David A. Richards, José Maria Mateos, Sylvain Hugel, Vincenzo de Paola, Pico Caroni, Beat H. Gähwiler, and R. Anne McKinney

    PNAS April 26, 2005 102 (17) 6166-6171; https://doi.org/10.1073/pnas.0501881102
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    Adaptation without parameter change: Dynamic gain control in motion detection

    Alexander Borst, Virginia L. Flanagin, and Haim Sompolinsky

    PNAS April 26, 2005 102 (17) 6172-6176; https://doi.org/10.1073/pnas.0500491102
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    Identifying photoreceptors in blind eyes caused by RPE65 mutations: Prerequisite for human gene therapy success

    Samuel G. Jacobson, Tomas S. Aleman, Artur V. Cideciyan, Alexander Sumaroka, Sharon B. Schwartz, Elizabeth A. M. Windsor, Elias I. Traboulsi, Elise Heon, Steven J. Pittler, Ann H. Milam, Albert M. Maguire, Krzysztof Palczewski, Edwin M. Stone, and Jean Bennett

    PNAS April 26, 2005 102 (17) 6177-6182; https://doi.org/10.1073/pnas.0500646102
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    Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas

    Damián Refojo, Carlos Echenique, Marianne B. Müller, Johannes M. H. M. Reul, Jan M. Deussing, Wolfgang Wurst, Inge Sillaber, Marcelo Paez-Pereda, Florian Holsboer, and Eduardo Arzt

    PNAS April 26, 2005 102 (17) 6183-6188; https://doi.org/10.1073/pnas.0502070102
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    Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens

    Jeffrey W. Dalley, Kristjan Lääne, David E. H. Theobald, Hannah C. Armstrong, Philip R. Corlett, Yogita Chudasama, and Trevor W. Robbins

    PNAS April 26, 2005 102 (17) 6189-6194; https://doi.org/10.1073/pnas.0502080102

• Pharmacology

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    A brain detoxifying enzyme for organophosphorus nerve poisons

    Daniel K. Nomura, Donmienne Leung, Kyle P. Chiang, Gary B. Quistad, Benjamin F. Cravatt, and John E. Casida

    PNAS April 26, 2005 102 (17) 6195-6200; https://doi.org/10.1073/pnas.0501915102
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    Structural basis for antagonism and resistance of bicalutamide in prostate cancer

    Casey E. Bohl, Wenqing Gao, Duane D. Miller, Charles E. Bell, and James T. Dalton

    PNAS April 26, 2005 102 (17) 6201-6206; https://doi.org/10.1073/pnas.0500381102

• Physiology

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    Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance

    Julie R. Jones, Cordelia Barrick, Kyoung-Ah Kim, Jill Lindner, Bertrand Blondeau, Yuka Fujimoto, Masakazu Shiota, Robert A. Kesterson, Barbara B. Kahn, and Mark A. Magnuson

    PNAS April 26, 2005 102 (17) 6207-6212; https://doi.org/10.1073/pnas.0306743102
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    The rapid release of corticosterone from the adrenal induced by ACTH is mediated by nitric oxide acting by prostaglandin E₂

    Claudia E. Mohn, Javier Fernandez-Solari, Andrea De Laurentiis, Juan Pablo Prestifilippo, Carolina de la Cal, Richard Funk, Stefan R. Bornstein, Samuel M. McCann, and Valeria Rettori

    PNAS April 26, 2005 102 (17) 6213-6218; https://doi.org/10.1073/pnas.0502136102

• Plant Biology

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    A coiled-coil interaction mediates cauliflower mosaic virus cell-to-cell movement

    Livia Stavolone, Maria Elena Villani, Denis Leclerc, and Thomas Hohn

    PNAS April 26, 2005 102 (17) 6219-6224; https://doi.org/10.1073/pnas.0407731102
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    Dual targeting of the protein disulfide isomerase RB60 to the chloroplast and the endoplasmic reticulum

    Alexander Levitan, Tova Trebitsh, Vladimir Kiss, Yaron Pereg, Inbal Dangoor, and Avihai Danon

    PNAS April 26, 2005 102 (17) 6225-6230; https://doi.org/10.1073/pnas.0500676102