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Research Article

Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures

David A. Richards, José Maria Mateos, Sylvain Hugel, Vincenzo de Paola, Pico Caroni, Beat H. Gähwiler, and R. Anne McKinney
PNAS April 26, 2005 102 (17) 6166-6171; https://doi.org/10.1073/pnas.0501881102
David A. Richards
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José Maria Mateos
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Sylvain Hugel
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Vincenzo de Paola
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Pico Caroni
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Beat H. Gähwiler
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R. Anne McKinney
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  1. Communicated by Harald Reuter, University of Bern, Bern, Switzerland, March 8, 2005

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Article Information

vol. 102 no. 17 6166-6171
DOI: 
https://doi.org/10.1073/pnas.0501881102
PubMed: 
15831587

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Revision received October 25, 2004
  • Published in issue April 26, 2005.
  • Published first April 14, 2005.

Copyright & Usage: 
Copyright © 2005, The National Academy of Sciences Freely available online through the PNAS open access option.

Author Information

  1. David A. Richards*†,
  2. José Maria Mateos*,
  3. Sylvain Hugel*,
  4. Vincenzo de Paola‡§,
  5. Pico Caroni‡,
  6. Beat H. Gähwiler*¶, and
  7. R. Anne McKinney*∥
  1. *Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland; and ‡Friedrich Miescher Institute, Novartis Research Foundation, Maulbeerstrasse 66, CH-4058 Basel, Switzerland
  1. Communicated by Harald Reuter, University of Bern, Bern, Switzerland, March 8, 2005

Footnotes

    • ↵¶ To whom correspondence should be addressed. E-mail: gahwiler{at}hifo.unizh.ch.

    • ↵† Present address: Department of Cell Biology, Neurobiology, and Anatomy, Vontz Center for Molecular Studies, 3125 Eden Avenue, Cincinnati, OH 45267-0521.

    • ↵§ Present address: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724.

    • ↵∥ Present address: Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir-William-Osler, Montréal, QC, Canada H3G 1Y6.

    • Author contributions: D.A.R., B.H.G., and R.A.M. designed research; D.A.R. and J.M.M. performed research; V.d.P. and P.C. contributed new reagents/analytic tools; D.A.R., S.H., and R.A.M. analyzed data; and D.A.R., R.A.M., and B.H.G. wrote the paper.

    • Abbreviations: AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; mGFP, membrane-targeted GFP; NBQX, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulphonamide; SHP, spine head protrusion; TTX, tetrodotoxin.

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      Dominique Muller, Mathias De Roo, Irina Nikonenko
      2014

    Article usage

    Article usage: April 2005 to January 2021

    AbstractFullPdf
    Apr 200571771538
    May 2005331203254
    Jun 20051011298
    Jul 20051210691
    Aug 2005813663
    Sep 2005159056
    Oct 20051510369
    Nov 200598160
    Dec 2005126251
    Total 200511299641280
    Jan 2006128439
    Feb 2006206033
    Mar 200655733
    Apr 200699152
    May 200695535
    Jun 200625339
    Jul 200613521
    Aug 200623218
    Sep 200654224
    Oct 200645421
    Nov 200664423
    Dec 2006103417
    Total 200685641355
    Jan 200784932
    Feb 200763323
    Mar 200733529
    Apr 2007325745
    May 2007102523
    Jun 200792119
    Jul 200761365
    Aug 200764026
    Sep 200732716
    Oct 200781610
    Nov 200763910
    Dec 200753013
    Total 2007102385311
    Jan 200802414
    Feb 200832712
    Mar 200853915
    Apr 2008103718
    May 2008183214
    Jun 2008202911
    Jul 200830745
    Aug 2008282116
    Sep 2008544016
    Oct 2008232517
    Nov 2008231911
    Dec 2008353413
    Total 2008249334202
    Jan 2009313013
    Feb 2009274713
    Mar 200914454
    Apr 2009147017
    May 2009175317
    Jun 2009147821
    Jul 2009116111
    Aug 2009104212
    Sep 200952917
    Oct 2009193714
    Nov 2009104717
    Dec 200910308
    Total 2009182569164
    Jan 20109338
    Feb 2010133813
    Mar 2010102811
    Apr 201093214
    May 201093116
    Jun 2010135014
    Jul 2010123813
    Aug 2010243412
    Sep 2010124015
    Oct 2010134812
    Nov 2010104117
    Dec 201010294
    Total 2010144442149
    Jan 2011184918
    Feb 2011144111
    Mar 2011123311
    Apr 20117338
    May 2011104621
    Jun 2011202413
    Jul 2011123011
    Aug 201192713
    Sep 2011212814
    Oct 20116448
    Nov 2011134318
    Dec 201116399
    Total 2011158437155
    Jan 201231308
    Feb 201215419
    Mar 2012122411
    Apr 20125318
    May 2012132513
    Jun 201214199
    Jul 201211289
    Aug 20124407
    Sep 201218337
    Oct 201215188
    Nov 201219178
    Dec 201215193
    Total 2012172325100
    Jan 201313197
    Feb 201319246
    Mar 2013223910
    Apr 2013292114
    May 2013124315
    Jun 201315336
    Jul 2013111910
    Aug 20137136
    Sep 2013121912
    Oct 201312168
    Nov 20139165
    Dec 201313178
    Total 2013174279107
    Jan 201415254
    Feb 20141154
    Mar 201423297
    Apr 2014241110
    May 201414214
    Jun 201417105
    Jul 201416186
    Aug 201422245
    Sep 2014281913
    Oct 201419107
    Nov 20141282
    Dec 201415106
    Total 201421619073
    Jan 201510155
    Feb 20151084
    Mar 20151826
    Apr 20157106
    May 201519139
    Jun 2015767
    Jul 201561113
    Aug 20151466
    Sep 20151186
    Oct 20151064
    Nov 20151151
    Dec 2015746
    Total 20151309473
    Jan 2016101711
    Feb 2016122415
    Mar 201611610
    Apr 20161083
    May 201613132
    Jun 201610107
    Jul 20161265
    Aug 20162336
    Sep 201613107
    Oct 201621142
    Nov 20161376
    Dec 201620105
    Total 201616812879
    Jan 20171368
    Feb 201723144
    Mar 20171065
    Apr 20171233
    May 20171678
    Jun 2017925
    Jul 20171293
    Aug 201714118
    Sep 20171365
    Oct 2017965
    Nov 201716104
    Dec 2017663
    Total 20171538661
    Jan 2018976
    Feb 201820254
    Mar 2018283810
    Apr 201832357
    May 201822264
    Jun 201820185
    Jul 201813133
    Aug 2018172513
    Sep 201817196
    Oct 20181346
    Nov 20183397
    Dec 20181234
    Total 201818330275
    Jan 20192165
    Feb 201912210
    Mar 20193279
    Apr 201932810
    May 20192192
    Jun 2019597
    Jul 20190239
    Aug 201912113
    Sep 20191133
    Oct 20195259
    Nov 20193247
    Dec 201953614
    Total 20193126398
    Jan 20203267
    Feb 2020084
    Mar 20201168
    Apr 20202209
    May 20201266
    Jun 202042113
    Jul 20201308
    Aug 20200165
    Sep 20202326
    Oct 202093011
    Nov 20205215
    Dec 20207244
    Total 20203527086
    Jan 20211238
    Total 20211238
    Total331257323376
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    Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures
    David A. Richards, José Maria Mateos, Sylvain Hugel, Vincenzo de Paola, Pico Caroni, Beat H. Gähwiler, R. Anne McKinney
    Proceedings of the National Academy of Sciences Apr 2005, 102 (17) 6166-6171; DOI: 10.1073/pnas.0501881102

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    Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures
    David A. Richards, José Maria Mateos, Sylvain Hugel, Vincenzo de Paola, Pico Caroni, Beat H. Gähwiler, R. Anne McKinney
    Proceedings of the National Academy of Sciences Apr 2005, 102 (17) 6166-6171; DOI: 10.1073/pnas.0501881102
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    Proceedings of the National Academy of Sciences: 102 (17)
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