Table of Contents

Biological Sciences

• Anthropology

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    Prolonged coexistence of humans and megafauna in Pleistocene Australia

    Clive N. G. Trueman, Judith H. Field, Joe Dortch, Bethan Charles, and Stephen Wroe

    PNAS June 7, 2005 102 (23) 8381-8385; https://doi.org/10.1073/pnas.0408975102

• Applied Biological Sciences

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    Building a human kinase gene repository: Bioinformatics, molecular cloning, and functional validation

    Jaehong Park, Yanhui Hu, T. V. S. Murthy, Fredrik Vannberg, Binghua Shen, Andreas Rolfs, Jessica E. Hutti, Lewis C. Cantley, Joshua LaBaer, Ed Harlow, and Leonardo Brizuela

    PNAS June 7, 2005 102 (23) 8114-8119; https://doi.org/10.1073/pnas.0503141102

• Biochemistry

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    Functional analysis of the pseudoknot structure in human telomerase RNA

    • Inaugural Article

    Jiunn-Liang Chen and Carol W. Greider

    PNAS June 7, 2005 102 (23) 8080-8085; https://doi.org/10.1073/pnas.0502259102

    See companion article:

    • Biography of Carol W. Greider

      - May 31, 2005
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    An expression screen reveals modulators of class II histone deacetylase phosphorylation

    Shurong Chang, Svetlana Bezprozvannaya, Shijie Li, and Eric N. Olson

    PNAS June 7, 2005 102 (23) 8120-8125; https://doi.org/10.1073/pnas.0503275102
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    Splicing potentiation by growth factor signals via estrogen receptor phosphorylation

    Yoshikazu Masuhiro, Yoshihiro Mezaki, Matomo Sakari, Ken-ichi Takeyama, Tasuku Yoshida, Kunio Inoue, Junn Yanagisawa, Shigemasa Hanazawa, Bert W. O'Malley, and Shigeaki Kato

    PNAS June 7, 2005 102 (23) 8126-8131; https://doi.org/10.1073/pnas.0503197102
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    The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

    Margarita Garcia-Calvo, JeanMarie Lisnock, Herbert G. Bull, Brian E. Hawes, Duane A. Burnett, Matthew P. Braun, James H. Crona, Harry R. Davis Jr., Dennis C. Dean, Patricia A. Detmers, Michael P. Graziano, Meredith Hughes, D. Euan MacIntyre, Anthony Ogawa, Kim A. O'Neill, Sai Prasad N. Iyer, Diane E. Shevell, Marsha M. Smith, Yui S. Tang, Amanda M. Makarewicz, Feroze Ujjainwalla, Scott W. Altmann, Kevin T. Chapman, and Nancy A. Thornberry

    PNAS June 7, 2005 102 (23) 8132-8137; https://doi.org/10.1073/pnas.0500269102
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    A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly

    Stephen J. Stray, Christina R. Bourne, Sreenivas Punna, Warren G. Lewis, M. G. Finn, and Adam Zlotnick

    PNAS June 7, 2005 102 (23) 8138-8143; https://doi.org/10.1073/pnas.0409732102
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    The T4-encoded cochaperonin, gp31, has unique properties that explain its requirement for the folding of the T4 major capsid protein

    Patrick J. Bakkes, Bart W. Faber, Harm van Heerikhuizen, and Saskia M. van der Vies

    PNAS June 7, 2005 102 (23) 8144-8149; https://doi.org/10.1073/pnas.0500048102
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    STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-α3

    Ling Liu, Kevin M. McBride, and Nancy C. Reich

    PNAS June 7, 2005 102 (23) 8150-8155; https://doi.org/10.1073/pnas.0501643102
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    TrwB, the coupling protein involved in DNA transport during bacterial conjugation, is a DNA-dependent ATPase

    I. Tato, S. Zunzunegui, F. de la Cruz, and E. Cabezon

    PNAS June 7, 2005 102 (23) 8156-8161; https://doi.org/10.1073/pnas.0503402102
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    Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycle

    Marcin Golczak, Vladimir Kuksa, Tadao Maeda, Alexander R. Moise, and Krzysztof Palczewski

    PNAS June 7, 2005 102 (23) 8162-8167; https://doi.org/10.1073/pnas.0503318102
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    Characterization of human glutaredoxin 2 as iron–sulfur protein: A possible role as redox sensor

    Christopher Horst Lillig, Carsten Berndt, Olivia Vergnolle, Maria Elisabet Lönn, Christoph Hudemann, Eckhard Bill, and Arne Holmgren

    PNAS June 7, 2005 102 (23) 8168-8173; https://doi.org/10.1073/pnas.0500735102

• Biophysics

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    Energy landscape of amyloidogenic peptide oligomerization by parallel-tempering molecular dynamics simulation: Significant role of Asn ladder

    Hui-Hsu (Gavin) Tsai, Meital Reches, Chung-Jung Tsai, Kannan Gunasekaran, Ehud Gazit, and Ruth Nussinov

    PNAS June 7, 2005 102 (23) 8174-8179; https://doi.org/10.1073/pnas.0408653102
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    Electrostatic mechanism of nucleosomal array folding revealed by computer simulation

    Jian Sun, Qing Zhang, and Tamar Schlick

    PNAS June 7, 2005 102 (23) 8180-8185; https://doi.org/10.1073/pnas.0408867102
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    Holliday junction dynamics and branch migration: Single-molecule analysis

    Mikhail Karymov, Douglas Daniel, Otto F. Sankey, and Yuri L. Lyubchenko

    PNAS June 7, 2005 102 (23) 8186-8191; https://doi.org/10.1073/pnas.0407210102
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    Heptameric (L12)₆/L10 rather than canonical pentameric complexes are found by tandem MS of intact ribosomes from thermophilic bacteria

    Leopold L. Ilag, Hortense Videler, Adam R. McKay, Frank Sobott, Paola Fucini, Knud H. Nierhaus, and Carol V. Robinson

    PNAS June 7, 2005 102 (23) 8192-8197; https://doi.org/10.1073/pnas.0502193102
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    HIV dynamics with multiple infections of target cells

    Narendra M. Dixit and Alan S. Perelson

    PNAS June 7, 2005 102 (23) 8198-8203; https://doi.org/10.1073/pnas.0407498102

• Cell Biology

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    The coordinate regulation of the p53 and mTOR pathways in cells

    Zhaohui Feng, Haiyan Zhang, Arnold J. Levine, and Shengkan Jin

    PNAS June 7, 2005 102 (23) 8204-8209; https://doi.org/10.1073/pnas.0502857102
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    Nucleosome assembly protein-1 is a linker histone chaperone in Xenopus eggs

    Keishi Shintomi, Mari Iwabuchi, Hideaki Saeki, Kiyoe Ura, Takeo Kishimoto, and Keita Ohsumi

    PNAS June 7, 2005 102 (23) 8210-8215; https://doi.org/10.1073/pnas.0500822102
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    Cell and plastid division are coordinated through the prereplication factor AtCDT1

    Cécile Raynaud, Claudette Perennes, Christophe Reuzeau, Olivier Catrice, Spencer Brown, and Catherine Bergounioux

    PNAS June 7, 2005 102 (23) 8216-8221; https://doi.org/10.1073/pnas.0502564102
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    The telomerase reverse transcriptase regulates chromatin state and DNA damage responses

    Kenkichi Masutomi, Richard Possemato, Judy M. Y. Wong, Jennifer L. Currier, Zuzana Tothova, Judith B. Manola, Shridar Ganesan, Peter M. Lansdorp, Kathleen Collins, and William C. Hahn

    PNAS June 7, 2005 102 (23) 8222-8227; https://doi.org/10.1073/pnas.0503095102
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    Dynamic positioning of the fission yeast cell division plane

    Rafael R. Daga and Fred Chang

    PNAS June 7, 2005 102 (23) 8228-8232; https://doi.org/10.1073/pnas.0409021102

• Developmental Biology

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    Distinct effectors of platelet-derived growth factor receptor-α signaling are required for cell survival during embryogenesis

    Melanie Van Stry, Andrius Kazlauskas, Stuart L. Schreiber, and Karen Symes

    PNAS June 7, 2005 102 (23) 8233-8238; https://doi.org/10.1073/pnas.0502885102
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    Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos

    Paul J. Tesar

    PNAS June 7, 2005 102 (23) 8239-8244; https://doi.org/10.1073/pnas.0503231102

• Ecology

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    Climate change threats to plant diversity in Europe

    Wilfried Thuiller, Sandra Lavorel, Miguel B. Araújo, Martin T. Sykes, and I. Colin Prentice

    PNAS June 7, 2005 102 (23) 8245-8250; https://doi.org/10.1073/pnas.0409902102

    See companion article:

    • This Week in PNAS

      - Jun 07, 2005
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    Foliage shedding in deciduous forests lifts up long-distance seed dispersal by wind

    Ran Nathan and Gabriel G. Katul

    PNAS June 7, 2005 102 (23) 8251-8256; https://doi.org/10.1073/pnas.0503048102

• Evolution

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    Reconstructing the tempo and mode of evolution in an extinct clade of birds with ancient DNA: The giant moas of New Zealand

    Allan J. Baker, Leon J. Huynen, Oliver Haddrath, Craig D. Millar, and David M. Lambert

    PNAS June 7, 2005 102 (23) 8257-8262; https://doi.org/10.1073/pnas.0409435102
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    Hamilton's indicators of the force of selection

    Annette Baudisch

    PNAS June 7, 2005 102 (23) 8263-8268; https://doi.org/10.1073/pnas.0502155102

• Genetics

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    Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

    • Inaugural Article

    Igor Splawski, Katherine W. Timothy, Niels Decher, Pradeep Kumar, Frank B. Sachse, Alan H. Beggs, Michael C. Sanguinetti, and Mark T. Keating

    PNAS June 7, 2005 102 (23) 8089-8096; https://doi.org/10.1073/pnas.0502506102

    See companion article:

    • Biography of Mark T. Keating

      - May 31, 2005
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    Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories

    Stepan N. Belyakin, George K. Christophides, Artyom A. Alekseyenko, Evgenia V. Kriventseva, Elena S. Belyaeva, Roman A. Nanayev, Igor V. Makunin, Heidelberg Fly Array Consortium§ § , Fotis C. Kafatos, and Igor F. Zhimulev

    PNAS June 7, 2005 102 (23) 8269-8274; https://doi.org/10.1073/pnas.0502702102

• Immunology

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    Development of a transgenic mouse model susceptible to human coronavirus 229E

    • From the Cover

    Caroline Lassnig, Carlos M. Sanchez, Monika Egerbacher, Ingrid Walter, Susanne Majer, Thomas Kolbe, Pilar Pallares, Luis Enjuanes, and Mathias Müller

    PNAS June 7, 2005 102 (23) 8275-8280; https://doi.org/10.1073/pnas.0408589102

    See companion article:

    • This Week in PNAS

      - Jun 07, 2005
    • Humanized mice develop coronavirus respiratory disease

      - May 31, 2005

• Medical Sciences

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    Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations

    • Inaugural Article

    Igor Splawski, Katherine W. Timothy, Niels Decher, Pradeep Kumar, Frank B. Sachse, Alan H. Beggs, Michael C. Sanguinetti, and Mark T. Keating

    PNAS June 7, 2005 102 (23) 8089-8096; https://doi.org/10.1073/pnas.0502506102

    See companion article:

    • Biography of Mark T. Keating

      - May 31, 2005
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    Essential role for Gα₁₃ in endothelial cells during embryonic development

    Kathleen M. Ruppel, David Willison, Hiroshi Kataoka, Alice Wang, Yao-Wu Zheng, Ivo Cornelissen, Liya Yin, Shan Mei Xu, and Shaun R. Coughlin

    PNAS June 7, 2005 102 (23) 8281-8286; https://doi.org/10.1073/pnas.0503326102
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    Influence of in vivo growth on human glioma cell line gene expression: Convergent profiles under orthotopic conditions

    • From the Cover

    Kevin Camphausen, Benjamin Purow, Mary Sproull, Tamalee Scott, Tomoko Ozawa, Dennis F. Deen, and Philip J. Tofilon

    PNAS June 7, 2005 102 (23) 8287-8292; https://doi.org/10.1073/pnas.0502887102
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    Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo

    Nina Jendreyko, Mikhail Popkov, Christoph Rader, and Carlos F. Barbas III

    PNAS June 7, 2005 102 (23) 8293-8298; https://doi.org/10.1073/pnas.0503168102
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    Correlations between apolipoprotein E ε4 gene dose and brain-imaging measurements of regional hypometabolism

    • From the Cover

    Eric M. Reiman, Kewei Chen, Gene E. Alexander, Richard J. Caselli, Daniel Bandy, David Osborne, Ann M. Saunders, and John Hardy

    PNAS June 7, 2005 102 (23) 8299-8302; https://doi.org/10.1073/pnas.0500579102
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    Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia

    Philip W. Gold, Ma-Li Wong, David S. Goldstein, Herman K. Gold, Donna S. Ronsaville, Murray Esler, Salvatore Alesci, Anwar Masood, Julio Licinio, Thomas D. Geracioti Jr., Giulia Perini, Michael D. DeBellis, Courtney Holmes, Alexandros N. Vgontzas, Dennis S. Charney, George P. Chrousos, Samuel M. McCann, and Mitchel A. Kling

    PNAS June 7, 2005 102 (23) 8303-8308; https://doi.org/10.1073/pnas.0503069102
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    Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice

    Gideon M. Hirschfield, J. Ruth Gallimore, Melvyn C. Kahan, Winston L. Hutchinson, Caroline A. Sabin, G. Martin Benson, Amar P. Dhillon, Glenys A. Tennent, and Mark B. Pepys

    PNAS June 7, 2005 102 (23) 8309-8314; https://doi.org/10.1073/pnas.0503202102

    See companion article:

    • This Week in PNAS

      - Jun 07, 2005
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    Microtubule-associated protein tau: A marker of paclitaxel sensitivity in breast cancer

    Roman Rouzier, Radhika Rajan, Peter Wagner, Kenneth R. Hess, David L. Gold, James Stec, Mark Ayers, Jeffrey S. Ross, Peter Zhang, Thomas A. Buchholz, Henry Kuerer, Marjorie Green, Banu Arun, Gabriel N. Hortobagyi, W. Fraser Symmans, and Lajos Pusztai

    PNAS June 7, 2005 102 (23) 8315-8320; https://doi.org/10.1073/pnas.0408974102

• Microbiology

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    Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo

    Rodolphe Suspène, Denise Guétard, Michel Henry, Peter Sommer, Simon Wain-Hobson, and Jean-Pierre Vartanian

    PNAS June 7, 2005 102 (23) 8321-8326; https://doi.org/10.1073/pnas.0408223102
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    Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages

    • From the Cover

    Jyothi Rengarajan, Barry R. Bloom, and Eric J. Rubin

    PNAS June 7, 2005 102 (23) 8327-8332; https://doi.org/10.1073/pnas.0503272102

    See companion article:

    • This Week in PNAS

      - Jun 07, 2005

• Neuroscience

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    Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

    Simone Di Giovanni, Vilen Movsesyan, Farid Ahmed, Ibolja Cernak, Sergio Schinelli, Bogdan Stoica, and Alan I. Faden

    PNAS June 7, 2005 102 (23) 8333-8338; https://doi.org/10.1073/pnas.0500989102
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    Night-vision brain area in migratory songbirds

    Henrik Mouritsen, Gesa Feenders, Miriam Liedvogel, Kazuhiro Wada, and Erich D. Jarvis

    PNAS June 7, 2005 102 (23) 8339-8344; https://doi.org/10.1073/pnas.0409575102
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    Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor β-subunit

    Hiromi Hirata, Louis Saint-Amant, Gerald B. Downes, Wilson W. Cui, Weibin Zhou, Michael Granato, and John Y. Kuwada

    PNAS June 7, 2005 102 (23) 8345-8350; https://doi.org/10.1073/pnas.0500862102
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    Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex

    Hiroyuki Oya, Ralph Adolphs, Hiroto Kawasaki, Antoine Bechara, Antonio Damasio, and Matthew A. Howard III

    PNAS June 7, 2005 102 (23) 8351-8356; https://doi.org/10.1073/pnas.0500899102
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    Regulation of anxiety and initiation of sexual behavior by CREB in the nucleus accumbens

    Michel Barrot, Deanna L. Wallace, Carlos A. Bolaños, Danielle L. Graham, Linda I. Perrotti, Rachael L. Neve, Heather Chambliss, Jerry C. Yin, and Eric J. Nestler

    PNAS June 7, 2005 102 (23) 8357-8362; https://doi.org/10.1073/pnas.0500587102

• Physiology

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    A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis

    Kristina K. Hansen, Philip M. Sherman, Laurie Cellars, Patricia Andrade-Gordon, Zhengying Pan, Amos Baruch, John L. Wallace, Morley D. Hollenberg, and Nathalie Vergnolle

    PNAS June 7, 2005 102 (23) 8363-8368; https://doi.org/10.1073/pnas.0409535102

• Plant Biology

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    Use of DNA barcodes to identify flowering plants

    W. John Kress, Kenneth J. Wurdack, Elizabeth A. Zimmer, Lee A. Weigt, and Daniel H. Janzen

    PNAS June 7, 2005 102 (23) 8369-8374; https://doi.org/10.1073/pnas.0503123102

• Psychology

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    Differentiating lexical form, meaning, and structure in the neural language system

    L. K. Tyler, W. D. Marslen-Wilson, and E. A. Stamatakis

    PNAS June 7, 2005 102 (23) 8375-8380; https://doi.org/10.1073/pnas.0408213102