Table of Contents

Biological Sciences

• Applied Biological Sciences

  • You have access

    Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses

    • From the Cover

    Moo-Yeal Lee, Chan Beum Park, Jonathan S. Dordick, and Douglas S. Clark

    PNAS January 25, 2005 102 (4) 983-987; https://doi.org/10.1073/pnas.0406755102

• Biochemistry

  • You have access

    Breaking sieve for steric exclusion of a noncognate amino acid from active site of a tRNA synthetase

    Manal A. Swairjo and Paul R. Schimmel

    PNAS January 25, 2005 102 (4) 988-993; https://doi.org/10.1073/pnas.0409024102
  • You have access

    Statistical coevolution analysis and molecular dynamics: Identification of amino acid pairs essential for catalysis

    R. August Estabrook, Jia Luo, Matthew M. Purdy, Vyas Sharma, Paul Weakliem, Thomas C. Bruice, and Norbert O. Reich

    PNAS January 25, 2005 102 (4) 994-999; https://doi.org/10.1073/pnas.0409128102

    See companion article:

    • This Week in PNAS

      - Jan 25, 2005
  • You have access

    Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters

    Pierre-Olivier Estève, Hang Gyeong Chin, and Sriharsa Pradhan

    PNAS January 25, 2005 102 (4) 1000-1005; https://doi.org/10.1073/pnas.0407729102
  • You have access

    α-Lytic protease can exist in two separately stable conformations with different His⁵⁷ mobilities and catalytic activities

    Kristin Coffman Haddad, James L. Sudmeier, Daniel A. Bachovchin, and William W. Bachovchin

    PNAS January 25, 2005 102 (4) 1006-1011; https://doi.org/10.1073/pnas.0409279102
  • You have access

    Characterization of potential selenium-binding proteins in the selenophosphate synthetase system

    Yuki Ogasawara, Gerard M. Lacourciere, Kazuyuki Ishii, and Thressa C. Stadtman

    PNAS January 25, 2005 102 (4) 1012-1016; https://doi.org/10.1073/pnas.0409042102
  • You have access

    Reconstitution of uridine-deletion precleaved RNA editing with two recombinant enzymes

    Xuedong Kang, Kestrel Rogers, Guanghan Gao, Arnold M. Falick, Sharleen Zhou, and Larry Simpson

    PNAS January 25, 2005 102 (4) 1017-1022; https://doi.org/10.1073/pnas.0409275102
  • You have access

    Altering the interaction between σ⁷⁰ and RNA polymerase generates complexes with distinct transcription-elongation properties

    Yvonne Berghöfer-Hochheimer, Chi Zen Lu, and Carol A. Gross

    PNAS January 25, 2005 102 (4) 1157-1162; https://doi.org/10.1073/pnas.0408973102

• Biophysics

  • You have access

    A fluorescent probe designed for studying protein conformational change

    Bruce E. Cohen, Arnd Pralle, XiaoJie Yao, Gayathri Swaminath, Chris S. Gandhi, Yuh Nung Jan, Brian K. Kobilka, Ehud Y. Isacoff, and Lily Y. Jan

    PNAS January 25, 2005 102 (4) 965-970; https://doi.org/10.1073/pnas.0409469102
  • You have access

    A partial atomic structure for the flagellar hook of Salmonella typhimurium

    Tanvir R. Shaikh, Dennis R. Thomas, James Z. Chen, Fadel A. Samatey, Hideyuki Matsunami, Katsumi Imada, Keiichi Namba, and David J. DeRosier

    PNAS January 25, 2005 102 (4) 1023-1028; https://doi.org/10.1073/pnas.0409020102
  • You have access

    The protein structure prediction problem could be solved using the current PDB library

    Yang Zhang and Jeffrey Skolnick

    PNAS January 25, 2005 102 (4) 1029-1034; https://doi.org/10.1073/pnas.0407152101
  • You have access

    Probing counterion modulated repulsion and attraction between nucleic acid duplexes in solution

    Yu Bai, Rhiju Das, Ian S. Millett, Daniel Herschlag, and Sebastian Doniach

    PNAS January 25, 2005 102 (4) 1035-1040; https://doi.org/10.1073/pnas.0404448102
  • You have access

    Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars

    Alison M. Skelley, James R. Scherer, Andrew D. Aubrey, William H. Grover, Robin H. C. Ivester, Pascale Ehrenfreund, Frank J. Grunthaner, Jeffrey L. Bada, and Richard A. Mathies

    PNAS January 25, 2005 102 (4) 1041-1046; https://doi.org/10.1073/pnas.0406798102
  • You have access

    In vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses

    Willy Supatto, Delphine Débarre, Bruno Moulia, Eric Brouzés, Jean-Louis Martin, Emmanuel Farge, and Emmanuel Beaurepaire

    PNAS January 25, 2005 102 (4) 1047-1052; https://doi.org/10.1073/pnas.0405316102
  • You have access

    The N-terminal to C-terminal motif in protein folding and function

    Mallela M. G. Krishna and S. Walter Englander

    PNAS January 25, 2005 102 (4) 1053-1058; https://doi.org/10.1073/pnas.0409114102

• Cell Biology

  • You have access

    Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter

    Zhao-Zhong Su, Devanand Sarkar, Luni Emdad, Gregory J. Duigou, Charles S. H. Young, Joy Ware, Aaron Randolph, Kristoffer Valerie, and Paul B. Fisher

    PNAS January 25, 2005 102 (4) 1059-1064; https://doi.org/10.1073/pnas.0409141102
  • You have access

    DNA damage-induced mitotic catastrophe is mediated by the Chk1-dependent mitotic exit DNA damage checkpoint

    Xingxu Huang, Thanh Tran, Lingna Zhang, Rashieda Hatcher, and Pumin Zhang

    PNAS January 25, 2005 102 (4) 1065-1070; https://doi.org/10.1073/pnas.0409130102
  • You have access

    Age-specific incidence of inherited versus sporadic cancers: A test of the multistage theory of carcinogenesis

    Steven A. Frank

    PNAS January 25, 2005 102 (4) 1071-1075; https://doi.org/10.1073/pnas.0407299102

• Developmental Biology

  • You have access

    Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice

    Yoshiko Sakurai, Kaori Ohgimoto, Yuki Kataoka, Nobuaki Yoshida, and Masabumi Shibuya

    PNAS January 25, 2005 102 (4) 1076-1081; https://doi.org/10.1073/pnas.0404984102
  • You have access

    Requirement for serum response factor for skeletal muscle growth and maturation revealed by tissue-specific gene deletion in mice

    Shijie Li, Michael P. Czubryt, John McAnally, Rhonda Bassel-Duby, James A. Richardson, Franziska F. Wiebel, Alfred Nordheim, and Eric N. Olson

    PNAS January 25, 2005 102 (4) 1082-1087; https://doi.org/10.1073/pnas.0409103102

• Ecology

  • You have access

    Recent biological invasion may hasten invasional meltdown by accelerating historical introductions

    Edwin D. Grosholz

    PNAS January 25, 2005 102 (4) 1088-1091; https://doi.org/10.1073/pnas.0308547102

• Evolution

  • You have access

    Elevated evolutionary rates in the laboratory strain of Saccharomyces cerevisiae

    Zhenglong Gu, Lior David, Dmitri Petrov, Ted Jones, Ronald W. Davis, and Lars M. Steinmetz

    PNAS January 25, 2005 102 (4) 1092-1097; https://doi.org/10.1073/pnas.0409159102

    See companion article:

    • This Week in PNAS

      - Jan 25, 2005

• Genetics

  • You have access

    Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

    Yan Leng, Jinyi Zhang, Karen Badour, Enrico Arpaia, Spencer Freeman, Pam Cheung, Michael Siu, and Katherine Siminovitch

    PNAS January 25, 2005 102 (4) 1098-1103; https://doi.org/10.1073/pnas.0409120102
  • You have access

    AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: Implication in stepwise leukemogenesis and response to Gleevec

    Yue-Ying Wang, Guang-Biao Zhou, Tong Yin, Bing Chen, Jing-Yi Shi, Wen-Xue Liang, Xiao-Long Jin, Jian-Hua You, Guang Yang, Zhi-Xiang Shen, Jue Chen, Shu-Min Xiong, Guo-Qiang Chen, Feng Xu, Yi-Wei Liu, Zhu Chen, and Sai-Juan Chen

    PNAS January 25, 2005 102 (4) 1104-1109; https://doi.org/10.1073/pnas.0408831102
  • You have access

    Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

    Koji Nakanishi, Yun-Gui Yang, Andrew J. Pierce, Toshiyasu Taniguchi, Martin Digweed, Alan D. D'Andrea, Zhao-Qi Wang, and Maria Jasin

    PNAS January 25, 2005 102 (4) 1110-1115; https://doi.org/10.1073/pnas.0407796102

• Immunology

  • You have access

    A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator

    Lino C. Gonzalez, Kelly M. Loyet, Jill Calemine-Fenaux, Vandana Chauhan, Bernd Wranik, Wenjun Ouyang, and Dan L. Eaton

    PNAS January 25, 2005 102 (4) 1116-1121; https://doi.org/10.1073/pnas.0409071102
  • You have access

    Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor

    Kwang-Min Choe, Hyangkyu Lee, and Kathryn V. Anderson

    PNAS January 25, 2005 102 (4) 1122-1126; https://doi.org/10.1073/pnas.0404952102
  • You have access

    Glycolipid presentation to natural killer T cells differs in an organ-dependent fashion

    John Schmieg, Guangli Yang, Richard W. Franck, Nico Van Rooijen, and Moriya Tsuji

    PNAS January 25, 2005 102 (4) 1127-1132; https://doi.org/10.1073/pnas.0408288102

• Medical Sciences

  • You have access

    Directing oncogenic fusion genes into stem cells via an SCL enhancer

    Mariko Eguchi, Minenori Eguchi-Ishimae, Anthony Green, Tariq Enver, and Mel Greaves

    PNAS January 25, 2005 102 (4) 1133-1138; https://doi.org/10.1073/pnas.0405318102
  • You have access

    Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection

    William S. Mason, Allison R. Jilbert, and Jesse Summers

    PNAS January 25, 2005 102 (4) 1139-1144; https://doi.org/10.1073/pnas.0409332102
  • You have access

    Imaging bacterial infections with radiolabeled 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil

    • From the Cover

    Chetan Bettegowda, Catherine A. Foss, Ian Cheong, Yuchuan Wang, Luis Diaz, Nishant Agrawal, James Fox, James Dick, Long H. Dang, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein, and Martin G. Pomper

    PNAS January 25, 2005 102 (4) 1145-1150; https://doi.org/10.1073/pnas.0408861102
  • You have access

    Mutation of the androgen receptor causes oncogenic transformation of the prostate

    Guangzhou Han, Grant Buchanan, Michael Ittmann, Jonathan M. Harris, Xiaoqing Yu, Francesco J. DeMayo, Wayne Tilley, and Norman M. Greenberg

    PNAS January 25, 2005 102 (4) 1151-1156; https://doi.org/10.1073/pnas.0408925102

• Microbiology

  • You have access

    Altering the interaction between σ⁷⁰ and RNA polymerase generates complexes with distinct transcription-elongation properties

    Yvonne Berghöfer-Hochheimer, Chi Zen Lu, and Carol A. Gross

    PNAS January 25, 2005 102 (4) 1157-1162; https://doi.org/10.1073/pnas.0408973102
  • You have access

    Pathogenic hantaviruses bind plexin–semaphorin–integrin domains present at the apex of inactive, bent αvβ3 integrin conformers

    Tracy Raymond, Elena Gorbunova, Irina N. Gavrilovskaya, and Erich R. Mackow

    PNAS January 25, 2005 102 (4) 1163-1168; https://doi.org/10.1073/pnas.0406743102
  • You have access

    EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections

    Monica L. Burts, Wade A. Williams, Kristin DeBord, and Dominique M. Missiakas

    PNAS January 25, 2005 102 (4) 1169-1174; https://doi.org/10.1073/pnas.0405620102
  • You have access

    Expression of a viral polymerase-bound host factor turns human cell lines permissive to a plant- and insect-infecting virus

    Ricardo B. de Medeiros, Juliana Figueiredo, Renato de O. Resende, and Antonio C. De Avila

    PNAS January 25, 2005 102 (4) 1175-1180; https://doi.org/10.1073/pnas.0406668102

• Neuroscience

  • You have access

    Visual speech speeds up the neural processing of auditory speech

    Virginie van Wassenhove, Ken W. Grant, and David Poeppel

    PNAS January 25, 2005 102 (4) 1181-1186; https://doi.org/10.1073/pnas.0408949102

    See companion article:

    • This Week in PNAS

      - Jan 25, 2005
  • You have access

    A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse

    Naoya Sawamura, Takako Sawamura-Yamamoto, Yuji Ozeki, Christopher A. Ross, and Akira Sawa

    PNAS January 25, 2005 102 (4) 1187-1192; https://doi.org/10.1073/pnas.0406543102
  • You have access

    Loss of perivascular aquaporin 4 may underlie deficient water and K⁺ homeostasis in the human epileptogenic hippocampus

    Tore Eid, Tih-Shih W. Lee, Marion J. Thomas, Mahmood Amiry-Moghaddam, Lars P. Bjørnsen, Dennis D. Spencer, Peter Agre, Ole P. Ottersen, and Nihal C. de Lanerolle

    PNAS January 25, 2005 102 (4) 1193-1198; https://doi.org/10.1073/pnas.0409308102
  • You have access

    Glutamate regulation of DARPP-32 phosphorylation in neostriatal neurons involves activation of multiple signaling cascades

    Akinori Nishi, Yasuo Watanabe, Hideho Higashi, Masatoshi Tanaka, Angus C. Nairn, and Paul Greengard

    PNAS January 25, 2005 102 (4) 1199-1204; https://doi.org/10.1073/pnas.0409138102
  • You have access

    Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo

    • From the Cover

    Binhai Zheng, Jasvinder Atwal, Carole Ho, Lauren Case, Xiao-lin He, K. Christopher Garcia, Oswald Steward, and Marc Tessier-Lavigne

    PNAS January 25, 2005 102 (4) 1205-1210; https://doi.org/10.1073/pnas.0409026102

    See companion article:

    • This Week in PNAS

      - Jan 25, 2005
  • You have access

    Gene delivery of human apolipoprotein E alters brain Aβ burden in a mouse model of Alzheimer's disease

    Jean-Cosme Dodart, Robert A. Marr, Milla Koistinaho, Beth M. Gregersen, Seema Malkani, Inder M. Verma, and Steven M. Paul

    PNAS January 25, 2005 102 (4) 1211-1216; https://doi.org/10.1073/pnas.0409072102
  • You have access

    Rhabdomeric phototransduction initiated by the vertebrate photopigment melanopsin

    Mauro Cesar Isoldi, Mark D. Rollag, Ana Maria de Lauro Castrucci, and Ignacio Provencio

    PNAS January 25, 2005 102 (4) 1217-1221; https://doi.org/10.1073/pnas.0409252102
  • You have access

    Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205

    Surajit Ganguly, Joan L. Weller, Anthony Ho, Philippe Chemineau, Benoit Malpaux, and David C. Klein

    PNAS January 25, 2005 102 (4) 1222-1227; https://doi.org/10.1073/pnas.0406871102
  • You have access

    Natural-scene geometry predicts the perception of angles and line orientation

    Catherine Q. Howe and Dale Purves

    PNAS January 25, 2005 102 (4) 1228-1233; https://doi.org/10.1073/pnas.0409311102
  • You have access

    The Müller-Lyer illusion explained by the statistics of image–source relationships

    Catherine Q. Howe and Dale Purves

    PNAS January 25, 2005 102 (4) 1234-1239; https://doi.org/10.1073/pnas.0409314102
  • You have access

    Redefining implicit and explicit memory: The functional neuroanatomy of priming, remembering, and control of retrieval

    Björn H. Schott, Richard N. Henson, Alan Richardson-Klavehn, Christine Becker, Volker Thoma, Hans-Jochen Heinze, and Emrah Düzel

    PNAS January 25, 2005 102 (4) 1257-1262; https://doi.org/10.1073/pnas.0409070102

• Physiology

  • You have access

    Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation

    • From the Cover

    Shingo Kajimura, Katsumi Aida, and Cunming Duan

    PNAS January 25, 2005 102 (4) 1240-1245; https://doi.org/10.1073/pnas.0407443102

• Psychology

  • You have access

    Anticipating the three-dimensional consequences of eye movements

    Mark Wexler

    PNAS January 25, 2005 102 (4) 1246-1251; https://doi.org/10.1073/pnas.0409241102