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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, and Ted M. Dawson
Andrew B. West
Darren J. Moore
Saskia Biskup
Artem Bugayenko
Wanli W. Smith
Christopher A. Ross
Valina L. Dawson
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Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved September 22, 2005 (received for review August 23, 2005)
Online Impact
Article Information
vol. 102 no. 46 16842-16847
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Published By:
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Online ISSN:
History:
- Published in issue November 15, 2005.
- Published first November 3, 2005.
Copyright & Usage:
Copyright © 2005, The National Academy of Sciences
Author Information
- Andrew B. West * , † , ‡,
- Darren J. Moore * , † , ‡,
- Saskia Biskup * , †,
- Artem Bugayenko * , †,
- Wanli W. Smith §,
- Christopher A. Ross † , § , ¶,
- Valina L. Dawson * , † , ¶ , ∥, and
- Ted M. Dawson * , † , ¶ , **
- *Institute for Cell Engineering, Departments of †Neurology, ¶Neuroscience, and ∥Physiology, and §Department of Psychiatry and Division of Neurobiology, 733 North Broadway, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
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Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved September 22, 2005 (received for review August 23, 2005)
Footnotes
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↵ ** To whom correspondence should be addressed at: 733 North Broadway, Suite 731, Broadway Research Building, Baltimore, MD 21205. E-mail: tdawson{at}jhmi.edu.
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↵ ‡ A.B.W. and D.J.M. contributed equally to this work
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Author contributions: A.B.W., D.J.M., and T.M.D. designed research; A.B.W., D.J.M., and A.B. performed research; A.B.W. contributed new reagents/analytic tools; A.B.W., D.J.M., S.B., C.A.R., W.W.S., V.L.D., and T.M.D. analyzed data; and A.B.W., D.J.M., and T.M.D. wrote the paper.
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Conflict of interest statement: No conflicts declared.
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This paper was submitted directly (Track II) to the PNAS office.
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Abbreviations: HA, hemagglutinin; LRRK2, leucine-rich repeat kinase 2; MBP, myelin basic protein; MLK, mixed-lineage kinase; PD, Parkinson's disease.
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See Commentary on page 16535.
- Copyright © 2005, The National Academy of Sciences
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, Ted M. Dawson
Proceedings of the National Academy of Sciences Nov 2005, 102 (46) 16842-16847; DOI: 10.1073/pnas.0507360102
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, Ted M. Dawson
Proceedings of the National Academy of Sciences Nov 2005, 102 (46) 16842-16847; DOI: 10.1073/pnas.0507360102
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- LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
- The scientific and clinical basis for the treatment of Parkinson disease (2009)
- Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
- CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity