Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Andrew B. West; Darren J. Moore; Saskia Biskup; Artem Bugayenko; Wanli W. Smith; Christopher A. Ross; Valina L. Dawson; Ted M. Dawson

doi:10.1073/pnas.0507360102

New Research In

Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved September 22, 2005 (received for review August 23, 2005)

Online Impact

Article Information

vol. 102 no. 46 16842-16847

DOI:

https://doi.org/10.1073/pnas.0507360102

PubMed:

16269541

Published By:

National Academy of Sciences

Print ISSN:

0027-8424

Online ISSN:

1091-6490

History:

Published in issue November 15, 2005.
Published first November 3, 2005.

Author Information

Andrew B. West * , † , ‡,
Darren J. Moore * , † , ‡,
Saskia Biskup * , †,
Artem Bugayenko * , †,
Wanli W. Smith §,
Christopher A. Ross † , § , ¶,
Valina L. Dawson * , † , ¶ , ∥, and
Ted M. Dawson * , † , ¶ , **

^*Institute for Cell Engineering, Departments of ^†Neurology, ^¶Neuroscience, and ^∥Physiology, and ^§Department of Psychiatry and Division of Neurobiology, 733 North Broadway, The Johns Hopkins University School of Medicine, Baltimore, MD 21205

Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved September 22, 2005 (received for review August 23, 2005)

Footnotes

↵ ** To whom correspondence should be addressed at: 733 North Broadway, Suite 731, Broadway Research Building, Baltimore, MD 21205. E-mail: tdawson{at}jhmi.edu.
↵ ‡ A.B.W. and D.J.M. contributed equally to this work
Author contributions: A.B.W., D.J.M., and T.M.D. designed research; A.B.W., D.J.M., and A.B. performed research; A.B.W. contributed new reagents/analytic tools; A.B.W., D.J.M., S.B., C.A.R., W.W.S., V.L.D., and T.M.D. analyzed data; and A.B.W., D.J.M., and T.M.D. wrote the paper.
Conflict of interest statement: No conflicts declared.
This paper was submitted directly (Track II) to the PNAS office.
Abbreviations: HA, hemagglutinin; LRRK2, leucine-rich repeat kinase 2; MBP, myelin basic protein; MLK, mixed-lineage kinase; PD, Parkinson's disease.
See Commentary on page 16535.

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Article usage

Article usage: November 2005 to January 2021

	Abstract	Full	Pdf
Nov 2005	1293	618	1173
Dec 2005	362	424	277
Total 2005	1655	1042	1450
Jan 2006	277	222	182
Feb 2006	145	180	148
Mar 2006	44	178	148
Apr 2006	42	160	83
May 2006	44	147	104
Jun 2006	25	145	77
Jul 2006	17	110	53
Aug 2006	16	97	48
Sep 2006	29	106	70
Oct 2006	42	142	98
Nov 2006	56	137	89
Dec 2006	41	100	81
Total 2006	778	1724	1181
Jan 2007	36	153	81
Feb 2007	38	118	71
Mar 2007	31	94	73
Apr 2007	48	73	47
May 2007	29	90	53
Jun 2007	15	60	41
Jul 2007	12	47	28
Aug 2007	26	59	33
Sep 2007	31	72	42
Oct 2007	50	73	47
Nov 2007	46	65	42
Dec 2007	35	53	23
Total 2007	397	957	581
Jan 2008	22	63	46
Feb 2008	30	70	36
Mar 2008	33	71	40
Apr 2008	41	69	37
May 2008	65	67	42
Jun 2008	35	75	47
Jul 2008	101	26	49
Aug 2008	93	31	28
Sep 2008	95	43	29
Oct 2008	86	36	35
Nov 2008	102	47	40
Dec 2008	52	43	23
Total 2008	755	641	452
Jan 2009	82	36	40
Feb 2009	82	39	39
Mar 2009	51	99	44
Apr 2009	41	79	39
May 2009	42	44	27
Jun 2009	56	49	41
Jul 2009	41	71	37
Aug 2009	32	45	42
Sep 2009	26	46	38
Oct 2009	81	41	33
Nov 2009	38	33	27
Dec 2009	51	29	34
Total 2009	623	611	441
Jan 2010	42	31	20
Feb 2010	58	32	37
Mar 2010	46	53	36
Apr 2010	62	44	39
May 2010	52	44	27
Jun 2010	33	42	33
Jul 2010	42	32	20
Aug 2010	96	44	29
Sep 2010	42	51	25
Oct 2010	49	58	47
Nov 2010	55	71	44
Dec 2010	32	43	24
Total 2010	609	545	381
Jan 2011	31	72	29
Feb 2011	27	75	31
Mar 2011	37	133	32
Apr 2011	36	65	33
May 2011	36	37	22
Jun 2011	32	50	28
Jul 2011	39	34	30
Aug 2011	33	26	26
Sep 2011	31	38	21
Oct 2011	46	74	25
Nov 2011	43	66	40
Dec 2011	40	27	24
Total 2011	431	697	341
Jan 2012	40	33	18
Feb 2012	31	56	26
Mar 2012	42	40	36
Apr 2012	30	33	21
May 2012	48	47	40
Jun 2012	39	44	24
Jul 2012	40	33	24
Aug 2012	27	10	16
Sep 2012	51	20	25
Oct 2012	41	37	30
Nov 2012	46	45	38
Dec 2012	28	25	23
Total 2012	463	423	321
Jan 2013	45	39	31
Feb 2013	41	55	24
Mar 2013	49	56	29
Apr 2013	85	58	35
May 2013	58	44	14
Jun 2013	39	50	23
Jul 2013	34	51	20
Aug 2013	32	80	18
Sep 2013	62	68	23
Oct 2013	67	60	31
Nov 2013	51	40	27
Dec 2013	56	35	22
Total 2013	619	636	297
Jan 2014	63	59	23
Feb 2014	35	41	13
Mar 2014	84	76	24
Apr 2014	59	78	24
May 2014	44	73	23
Jun 2014	37	46	19
Jul 2014	56	69	12
Aug 2014	55	112	13
Sep 2014	63	79	15
Oct 2014	72	100	15
Nov 2014	66	86	16
Dec 2014	53	58	15
Total 2014	687	877	212
Jan 2015	43	43	23
Feb 2015	73	60	17
Mar 2015	60	44	13
Apr 2015	66	66	15
May 2015	58	37	19
Jun 2015	43	41	15
Jul 2015	35	57	13
Aug 2015	46	52	20
Sep 2015	63	45	11
Oct 2015	99	56	16
Nov 2015	104	49	26
Dec 2015	66	60	35
Total 2015	756	610	223
Jan 2016	55	70	28
Feb 2016	28	99	13
Mar 2016	51	79	19
Apr 2016	39	192	23
May 2016	35	17	9
Jun 2016	38	42	22
Jul 2016	58	15	13
Aug 2016	53	31	20
Sep 2016	62	11	13
Oct 2016	64	34	23
Nov 2016	66	28	25
Dec 2016	74	31	15
Total 2016	623	649	223
Jan 2017	72	43	20
Feb 2017	75	44	19
Mar 2017	69	50	25
Apr 2017	66	34	10
May 2017	45	28	15
Jun 2017	61	20	16
Jul 2017	47	28	13
Aug 2017	52	22	49
Sep 2017	49	22	24
Oct 2017	79	50	17
Nov 2017	66	56	10
Dec 2017	35	30	19
Total 2017	716	427	237
Jan 2018	59	32	17
Feb 2018	57	47	19
Mar 2018	70	65	32
Apr 2018	86	51	25
May 2018	89	71	29
Jun 2018	64	50	15
Jul 2018	51	42	13
Aug 2018	74	65	17
Sep 2018	64	56	27
Oct 2018	23	55	14
Nov 2018	36	48	28
Dec 2018	24	111	28
Total 2018	697	693	264
Jan 2019	30	174	34
Feb 2019	17	109	47
Mar 2019	19	67	23
Apr 2019	26	64	33
May 2019	14	44	24
Jun 2019	17	39	12
Jul 2019	14	46	21
Aug 2019	20	61	39
Sep 2019	23	103	28
Oct 2019	18	84	24
Nov 2019	21	75	25
Dec 2019	14	53	12
Total 2019	233	919	322
Jan 2020	14	74	24
Feb 2020	28	66	14
Mar 2020	24	58	33
Apr 2020	29	76	52
May 2020	11	92	52
Jun 2020	14	54	22
Jul 2020	9	48	27
Aug 2020	5	35	19
Sep 2020	7	54	27
Oct 2020	18	96	55
Nov 2020	17	69	17
Dec 2020	26	77	46
Total 2020	202	799	388
Jan 2021	23	63	36
Total 2021	23	63	36
Total	10267	12313	7350