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Research Article

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, and Ted M. Dawson
PNAS November 15, 2005 102 (46) 16842-16847; https://doi.org/10.1073/pnas.0507360102
Andrew B. West
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Darren J. Moore
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Saskia Biskup
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Artem Bugayenko
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Wanli W. Smith
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Christopher A. Ross
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Valina L. Dawson
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Ted M. Dawson
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  1. Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved September 22, 2005 (received for review August 23, 2005)

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Article Information

vol. 102 no. 46 16842-16847
DOI: 
https://doi.org/10.1073/pnas.0507360102
PubMed: 
16269541

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue November 15, 2005.
  • Published first November 3, 2005.

Copyright & Usage: 
Copyright © 2005, The National Academy of Sciences

Author Information

  1. Andrew B. West * , † , ‡,
  2. Darren J. Moore * , † , ‡,
  3. Saskia Biskup * , †,
  4. Artem Bugayenko * , †,
  5. Wanli W. Smith §,
  6. Christopher A. Ross † , § , ¶,
  7. Valina L. Dawson * , † , ¶ , ∥, and
  8. Ted M. Dawson * , † , ¶ , **
  1. *Institute for Cell Engineering, Departments of †Neurology, ¶Neuroscience, and ∥Physiology, and §Department of Psychiatry and Division of Neurobiology, 733 North Broadway, The Johns Hopkins University School of Medicine, Baltimore, MD 21205
  1. Edited by Solomon H. Snyder, The Johns Hopkins University School of Medicine, Baltimore, MD, and approved September 22, 2005 (received for review August 23, 2005)

Footnotes

  • ↵ ** To whom correspondence should be addressed at: 733 North Broadway, Suite 731, Broadway Research Building, Baltimore, MD 21205. E-mail: tdawson{at}jhmi.edu.

  • ↵ ‡ A.B.W. and D.J.M. contributed equally to this work

  • Author contributions: A.B.W., D.J.M., and T.M.D. designed research; A.B.W., D.J.M., and A.B. performed research; A.B.W. contributed new reagents/analytic tools; A.B.W., D.J.M., S.B., C.A.R., W.W.S., V.L.D., and T.M.D. analyzed data; and A.B.W., D.J.M., and T.M.D. wrote the paper.

  • Conflict of interest statement: No conflicts declared.

  • This paper was submitted directly (Track II) to the PNAS office.

  • Abbreviations: HA, hemagglutinin; LRRK2, leucine-rich repeat kinase 2; MBP, myelin basic protein; MLK, mixed-lineage kinase; PD, Parkinson's disease.

  • See Commentary on page 16535.

  • Copyright © 2005, The National Academy of Sciences

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Article usage

Article usage: November 2005 to January 2021

AbstractFullPdf
Nov 200512936181173
Dec 2005362424277
Total 2005165510421450
Jan 2006277222182
Feb 2006145180148
Mar 200644178148
Apr 20064216083
May 200644147104
Jun 20062514577
Jul 20061711053
Aug 2006169748
Sep 20062910670
Oct 20064214298
Nov 20065613789
Dec 20064110081
Total 200677817241181
Jan 20073615381
Feb 20073811871
Mar 2007319473
Apr 2007487347
May 2007299053
Jun 2007156041
Jul 2007124728
Aug 2007265933
Sep 2007317242
Oct 2007507347
Nov 2007466542
Dec 2007355323
Total 2007397957581
Jan 2008226346
Feb 2008307036
Mar 2008337140
Apr 2008416937
May 2008656742
Jun 2008357547
Jul 20081012649
Aug 2008933128
Sep 2008954329
Oct 2008863635
Nov 20081024740
Dec 2008524323
Total 2008755641452
Jan 2009823640
Feb 2009823939
Mar 2009519944
Apr 2009417939
May 2009424427
Jun 2009564941
Jul 2009417137
Aug 2009324542
Sep 2009264638
Oct 2009814133
Nov 2009383327
Dec 2009512934
Total 2009623611441
Jan 2010423120
Feb 2010583237
Mar 2010465336
Apr 2010624439
May 2010524427
Jun 2010334233
Jul 2010423220
Aug 2010964429
Sep 2010425125
Oct 2010495847
Nov 2010557144
Dec 2010324324
Total 2010609545381
Jan 2011317229
Feb 2011277531
Mar 20113713332
Apr 2011366533
May 2011363722
Jun 2011325028
Jul 2011393430
Aug 2011332626
Sep 2011313821
Oct 2011467425
Nov 2011436640
Dec 2011402724
Total 2011431697341
Jan 2012403318
Feb 2012315626
Mar 2012424036
Apr 2012303321
May 2012484740
Jun 2012394424
Jul 2012403324
Aug 2012271016
Sep 2012512025
Oct 2012413730
Nov 2012464538
Dec 2012282523
Total 2012463423321
Jan 2013453931
Feb 2013415524
Mar 2013495629
Apr 2013855835
May 2013584414
Jun 2013395023
Jul 2013345120
Aug 2013328018
Sep 2013626823
Oct 2013676031
Nov 2013514027
Dec 2013563522
Total 2013619636297
Jan 2014635923
Feb 2014354113
Mar 2014847624
Apr 2014597824
May 2014447323
Jun 2014374619
Jul 2014566912
Aug 20145511213
Sep 2014637915
Oct 20147210015
Nov 2014668616
Dec 2014535815
Total 2014687877212
Jan 2015434323
Feb 2015736017
Mar 2015604413
Apr 2015666615
May 2015583719
Jun 2015434115
Jul 2015355713
Aug 2015465220
Sep 2015634511
Oct 2015995616
Nov 20151044926
Dec 2015666035
Total 2015756610223
Jan 2016557028
Feb 2016289913
Mar 2016517919
Apr 20163919223
May 201635179
Jun 2016384222
Jul 2016581513
Aug 2016533120
Sep 2016621113
Oct 2016643423
Nov 2016662825
Dec 2016743115
Total 2016623649223
Jan 2017724320
Feb 2017754419
Mar 2017695025
Apr 2017663410
May 2017452815
Jun 2017612016
Jul 2017472813
Aug 2017522249
Sep 2017492224
Oct 2017795017
Nov 2017665610
Dec 2017353019
Total 2017716427237
Jan 2018593217
Feb 2018574719
Mar 2018706532
Apr 2018865125
May 2018897129
Jun 2018645015
Jul 2018514213
Aug 2018746517
Sep 2018645627
Oct 2018235514
Nov 2018364828
Dec 20182411128
Total 2018697693264
Jan 20193017434
Feb 20191710947
Mar 2019196723
Apr 2019266433
May 2019144424
Jun 2019173912
Jul 2019144621
Aug 2019206139
Sep 20192310328
Oct 2019188424
Nov 2019217525
Dec 2019145312
Total 2019233919322
Jan 2020147424
Feb 2020286614
Mar 2020245833
Apr 2020297652
May 2020119252
Jun 2020145422
Jul 202094827
Aug 202053519
Sep 202075427
Oct 2020189655
Nov 2020176917
Dec 2020267746
Total 2020202799388
Jan 2021236336
Total 2021236336
Total10267123137350
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, Ted M. Dawson
Proceedings of the National Academy of Sciences Nov 2005, 102 (46) 16842-16847; DOI: 10.1073/pnas.0507360102

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
Andrew B. West, Darren J. Moore, Saskia Biskup, Artem Bugayenko, Wanli W. Smith, Christopher A. Ross, Valina L. Dawson, Ted M. Dawson
Proceedings of the National Academy of Sciences Nov 2005, 102 (46) 16842-16847; DOI: 10.1073/pnas.0507360102
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Proceedings of the National Academy of Sciences of the United States of America: 102 (46)
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