Table of Contents

Biological Sciences

• Agricultural Sciences

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    Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor

    Claudia Pérez, Luisa E. Fernandez, Jianguang Sun, Jorge Luis Folch, Sarjeet S. Gill, Mario Soberón, and Alejandra Bravo

    PNAS December 20, 2005 102 (51) 18303-18308; https://doi.org/10.1073/pnas.0505494102

• Anthropology

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    Cranial morphology of early Americans from Lagoa Santa, Brazil: Implications for the settlement of the New World

    Walter A. Neves and Mark Hubbe

    PNAS December 20, 2005 102 (51) 18309-18314; https://doi.org/10.1073/pnas.0507185102
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    An Asian origin for a 10,000-year-old domesticated plant in the Americas

    David L. Erickson, Bruce D. Smith, Andrew C. Clarke, Daniel H. Sandweiss, and Noreen Tuross

    PNAS December 20, 2005 102 (51) 18315-18320; https://doi.org/10.1073/pnas.0509279102

• Applied Biological Sciences

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    Generating highly ordered DNA nanostrand arrays

    • From the Cover

    Jingjiao Guan and L. James Lee

    PNAS December 20, 2005 102 (51) 18321-18325; https://doi.org/10.1073/pnas.0506902102

    See companion article:

    • This Week in PNAS

      - Dec 20, 2005

• Biochemistry

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    The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation

    Michael Sacher, Alessandra Di Bacco, Vladimir V. Lunin, Zheng Ye, John Wagner, Grace Gill, and Miroslaw Cygler

    PNAS December 20, 2005 102 (51) 18326-18331; https://doi.org/10.1073/pnas.0505071102
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    Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design

    Mi Li, Gary S. Laco, Mariusz Jaskolski, Jan Rozycki, Jerry Alexandratos, Alexander Wlodawer, and Alla Gustchina

    PNAS December 20, 2005 102 (51) 18332-18337; https://doi.org/10.1073/pnas.0509335102
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    The tethered motor domain of a kinesin-microtubule complex catalyzes reversible synthesis of bound ATP

    David D. Hackney

    PNAS December 20, 2005 102 (51) 18338-18343; https://doi.org/10.1073/pnas.0505288102
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    Sequence determinants of a conformational switch in a protein structure

    Thomas A. Anderson, Matthew H. J. Cordes, and Robert T. Sauer

    PNAS December 20, 2005 102 (51) 18344-18349; https://doi.org/10.1073/pnas.0509349102
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    Human La is found at RNA polymerase III-transcribed genes in vivo

    Jennifer A. Fairley, Theodoros Kantidakis, Niall S. Kenneth, Robert V. Intine, Richard J. Maraia, and Robert J. White

    PNAS December 20, 2005 102 (51) 18350-18355; https://doi.org/10.1073/pnas.0506415102
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    The proficiency of a thermophilic chorismate mutase enzyme is solely through an entropic advantage in the enzyme reaction

    Xiaohua Zhang and Thomas C. Bruice

    PNAS December 20, 2005 102 (51) 18356-18360; https://doi.org/10.1073/pnas.0509234102
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    Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases η and REV1

    Parie Garg and Peter M. Burgers

    PNAS December 20, 2005 102 (51) 18361-18366; https://doi.org/10.1073/pnas.0505949102
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    Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans

    Leslie I. Grad, Leanne C. Sayles, and Bernard D. Lemire

    PNAS December 20, 2005 102 (51) 18367-18372; https://doi.org/10.1073/pnas.0506939102
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    Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A

    Jason G. S. Ho, Antonio Greco, Maja Rupnik, and Kenneth K.-S. Ng

    PNAS December 20, 2005 102 (51) 18373-18378; https://doi.org/10.1073/pnas.0506391102
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    Solution structure of a multifunctional DNA- and protein-binding motif of human Werner syndrome protein

    Jin-Shan Hu, Hanqiao Feng, Wangyong Zeng, Guang-xin Lin, and Xu Guang Xi

    PNAS December 20, 2005 102 (51) 18379-18384; https://doi.org/10.1073/pnas.0509380102
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    Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling

    Bing Li, Samantha G. Pattenden, Daeyoup Lee, José Gutiérrez, Jie Chen, Chris Seidel, Jennifer Gerton, and Jerry L. Workman

    PNAS December 20, 2005 102 (51) 18385-18390; https://doi.org/10.1073/pnas.0507975102

• Biophysics

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    Solvent and mutation effects on the nucleation of amyloid β-protein folding

    Luis Cruz, Brigita Urbanc, Jose M. Borreguero, Noel D. Lazo, David B. Teplow, and H. Eugene Stanley

    PNAS December 20, 2005 102 (51) 18258-18263; https://doi.org/10.1073/pnas.0509276102
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    Structure of the streptococcal cell wall C5a peptidase

    C. Kent Brown, Zu-Yi Gu, Yury V. Matsuka, Sai S. Purushothaman, Laurie A. Winter, P. Patrick Cleary, Stephen B. Olmsted, Douglas H. Ohlendorf, and Cathleen A. Earhart

    PNAS December 20, 2005 102 (51) 18391-18396; https://doi.org/10.1073/pnas.0504954102
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    Snapshots of cytochrome c folding

    Ekaterina V. Pletneva, Harry B. Gray, and Jay R. Winkler

    PNAS December 20, 2005 102 (51) 18397-18402; https://doi.org/10.1073/pnas.0509076102
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    Diffusion and scaling during early embryonic pattern formation

    Thomas Gregor, William Bialek, Rob R. de Ruyter van Steveninck, David W. Tank, and Eric F. Wieschaus

    PNAS December 20, 2005 102 (51) 18403-18407; https://doi.org/10.1073/pnas.0509483102
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    Mechanism of metal ion activation of the diphtheria toxin repressor DtxR

    J. Alejandro D'Aquino, Jaclyn Tetenbaum-Novatt, Andre White, Fred Berkovitch, and Dagmar Ringe

    PNAS December 20, 2005 102 (51) 18408-18413; https://doi.org/10.1073/pnas.0500908102
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    Topology of biological networks and reliability of information processing

    Konstantin Klemm and Stefan Bornholdt

    PNAS December 20, 2005 102 (51) 18414-18419; https://doi.org/10.1073/pnas.0509132102

• Cell Biology

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    An antiviral role for the RNA interference machinery in Caenorhabditis elegans

    Daniel H. Schott, David K. Cureton, Sean P. Whelan, and Craig P. Hunter

    PNAS December 20, 2005 102 (51) 18420-18424; https://doi.org/10.1073/pnas.0507123102

    See companion article:

    • This Week in PNAS

      - Dec 20, 2005
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    Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

    Gabrielle G. M. Pinkse, Odette H. M. Tysma, Cees A. M. Bergen, Michel G. D. Kester, Ferry Ossendorp, Peter A. van Veelen, Bart Keymeulen, Danny Pipeleers, Jan W. Drijfhout, and Bart O. Roep

    PNAS December 20, 2005 102 (51) 18425-18430; https://doi.org/10.1073/pnas.0508621102
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    Up-regulation of β-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in B lymphoma cells

    Kyung Lib Jang, Julia Shackelford, So Young Seo, and Joseph S. Pagano

    PNAS December 20, 2005 102 (51) 18431-18436; https://doi.org/10.1073/pnas.0504054102
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    Differential cis-regulation of human versus mouse TERT gene expression in vivo: Identification of a human-specific repressive element

    Izumi Horikawa, Y. Jeffrey Chiang, Tricia Patterson, Lionel Feigenbaum, Sun-Hee Leem, Eriko Michishita, Vladimir Larionov, Richard J. Hodes, and J. Carl Barrett

    PNAS December 20, 2005 102 (51) 18437-18442; https://doi.org/10.1073/pnas.0508964102
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    The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

    Jean J. Zhao, Zhenning Liu, Li Wang, Eyoung Shin, Massimo F. Loda, and Thomas M. Roberts

    PNAS December 20, 2005 102 (51) 18443-18448; https://doi.org/10.1073/pnas.0508988102
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    Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment

    Christina Abrahamsberg, Peter Fuchs, Selma Osmanagic-Myers, Irmgard Fischer, Friedrich Propst, Adelheid Elbe-Bürger, and Gerhard Wiche

    PNAS December 20, 2005 102 (51) 18449-18454; https://doi.org/10.1073/pnas.0505380102

• Developmental Biology

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    Epicardial retinoid X receptor α is required for myocardial growth and coronary artery formation

    • From the Cover

    Esther Merki, Mónica Zamora, Angel Raya, Yasuhiko Kawakami, Jianming Wang, Xiaoxue Zhang, John Burch, Steven W. Kubalak, Perla Kaliman, Juan Carlos Izpisua Belmonte, Kenneth R. Chien, and Pilar Ruiz-Lozano

    PNAS December 20, 2005 102 (51) 18455-18460; https://doi.org/10.1073/pnas.0504343102

    See companion article:

    • This Week in PNAS

      - Dec 20, 2005
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    Two types of precursor cells in a multipotential hematopoietic cell line

    Zhi-jia Ye, Yuval Kluger, Zheng Lian, and Sherman M. Weissman

    PNAS December 20, 2005 102 (51) 18461-18466; https://doi.org/10.1073/pnas.0509314102
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    Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis

    Soojin Ryu, Jochen Holzschuh, Simone Erhardt, Anne-Kathrin Ettl, and Wolfgang Driever

    PNAS December 20, 2005 102 (51) 18467-18472; https://doi.org/10.1073/pnas.0506187102
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    The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney

    Sung-Kook Hong, Caroline E. Haldin, Nathan D. Lawson, Brant M. Weinstein, Igor B. Dawid, and Neil A. Hukriede

    PNAS December 20, 2005 102 (51) 18473-18478; https://doi.org/10.1073/pnas.0509457102
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    Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach

    Guillaume Junion, Teresa Jagla, Sebastien Duplant, Romain Tapin, Jean-Philippe Da Ponte, and Krzysztof Jagla

    PNAS December 20, 2005 102 (51) 18479-18484; https://doi.org/10.1073/pnas.0507030102
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    A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells

    Asim S. Siddiqui, Jaswinder Khattra, Allen D. Delaney, Yongjun Zhao, Caroline Astell, Jennifer Asano, Ryan Babakaiff, Sarah Barber, Jaclyn Beland, Slavita Bohacec, Mabel Brown-John, Steve Chand, David Charest, Anita M. Charters, Rebecca Cullum, Noreen Dhalla, Ruth Featherstone, Daniela S. Gerhard, Brad Hoffman, Robert A. Holt, Juan Hou, Byron Y.-L. Kuo, Lisa L. C. Lee, Stephanie Lee, Derek Leung, Kevin Ma, Corey Matsuo, Michael Mayo, Helen McDonald, Anna-liisa Prabhu, Pawan Pandoh, Gregory J. Riggins, Teresa Ruiz de Algara, James L. Rupert, Duane Smailus, Jeff Stott, Miranda Tsai, Richard Varhol, Pavle Vrljicak, David Wong, Mona K. Wu, Yuan-Yun Xie, George Yang, Ida Zhang, Martin Hirst, Steven J. M. Jones, Cheryl D. Helgason, Elizabeth M. Simpson, Pamela A. Hoodless, and Marco A. Marra

    PNAS December 20, 2005 102 (51) 18485-18490; https://doi.org/10.1073/pnas.0509455102
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    The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: Analysis of ESTs from the hermaphroditic strain

    Ricardo M. Zayas, Alvaro Hernández, Bianca Habermann, Yuying Wang, Joel M. Stary, and Phillip A. Newmark

    PNAS December 20, 2005 102 (51) 18491-18496; https://doi.org/10.1073/pnas.0509507102

• Ecology

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    Pinpointing and preventing imminent extinctions

    Taylor H. Ricketts, Eric Dinerstein, Tim Boucher, Thomas M. Brooks, Stuart H. M. Butchart, Michael Hoffmann, John F. Lamoreux, John Morrison, Mike Parr, John D. Pilgrim, Ana S. L. Rodrigues, Wes Sechrest, George E. Wallace, Ken Berlin, Jon Bielby, Neil D. Burgess, Don R. Church, Neil Cox, David Knox, Colby Loucks, Gary W. Luck, Lawrence L. Master, Robin Moore, Robin Naidoo, Robert Ridgely, George E. Schatz, Gavin Shire, Holly Strand, Wes Wettengel, and Eric Wikramanayake

    PNAS December 20, 2005 102 (51) 18497-18501; https://doi.org/10.1073/pnas.0509060102
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    Slow growth rates of Amazonian trees: Consequences for carbon cycling

    Simone Vieira, Susan Trumbore, Plinio B. Camargo, Diogo Selhorst, Jeffrey Q. Chambers, Niro Higuchi, and Luiz Antonio Martinelli

    PNAS December 20, 2005 102 (51) 18502-18507; https://doi.org/10.1073/pnas.0505966102

• Evolution

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    Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes

    Benjamin F. Voight, Alison M. Adams, Linda A. Frisse, Yudong Qian, Richard R. Hudson, and Anna Di Rienzo

    PNAS December 20, 2005 102 (51) 18508-18513; https://doi.org/10.1073/pnas.0507325102
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    Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection

    Simon D. W. Frost, Terri Wrin, Davey M. Smith, Sergei L. Kosakovsky Pond, Yang Liu, Ellen Paxinos, Colombe Chappey, Justin Galovich, Jeff Beauchaine, Christos J. Petropoulos, Susan J. Little, and Douglas D. Richman

    PNAS December 20, 2005 102 (51) 18514-18519; https://doi.org/10.1073/pnas.0504658102

• Genetics

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    Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations

    Ronald Roepman, Stef J. F. Letteboer, Heleen H. Arts, Sylvia E. C. van Beersum, Xinrong Lu, Elmar Krieger, Paulo A. Ferreira, and Frans P. M. Cremers

    PNAS December 20, 2005 102 (51) 18520-18525; https://doi.org/10.1073/pnas.0505774102
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    A high-resolution whole-genome cattle–human comparative map reveals details of mammalian chromosome evolution

    Annelie Everts-van der Wind, Denis M. Larkin, Cheryl A. Green, Janice S. Elliott, Colleen A. Olmstead, Readman Chiu, Jacqueline E. Schein, Marco A. Marra, James E. Womack, and Harris A. Lewin

    PNAS December 20, 2005 102 (51) 18526-18531; https://doi.org/10.1073/pnas.0509285102

• Immunology

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    Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc

    Hiroyuki O. Ishikawa, Shunsuke Higashi, Tomonori Ayukawa, Takeshi Sasamura, Motoo Kitagawa, Kenichi Harigaya, Kazuhisa Aoki, Nobuhiro Ishida, Yutaka Sanai, and Kenji Matsuno

    PNAS December 20, 2005 102 (51) 18532-18537; https://doi.org/10.1073/pnas.0504115102
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    Intraepithelial CD8⁺ tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

    Eiichi Sato, Sara H. Olson, Jiyoung Ahn, Brian Bundy, Hiroyoshi Nishikawa, Feng Qian, Achim A. Jungbluth, Denise Frosina, Sacha Gnjatic, Christine Ambrosone, James Kepner, Tosin Odunsi, Gerd Ritter, Shashikant Lele, Yao-Tseng Chen, Haruo Ohtani, Lloyd J. Old, and Kunle Odunsi

    PNAS December 20, 2005 102 (51) 18538-18543; https://doi.org/10.1073/pnas.0509182102
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    Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders

    Domenico Rosa, Giulietta Saletti, Ennio De Gregorio, Francesca Zorat, Consuelo Comar, Ugo D'Oro, Sandra Nuti, Michael Houghton, Vincenzo Barnaba, Gabriele Pozzato, and Sergio Abrignani

    PNAS December 20, 2005 102 (51) 18544-18549; https://doi.org/10.1073/pnas.0509402102
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    Social relationships, sleep quality, and interleukin-6 in aging women

    Elliot M. Friedman, Mary S. Hayney, Gayle D. Love, Heather L. Urry, Melissa A. Rosenkranz, Richard J. Davidson, Burton H. Singer, and Carol D. Ryff

    PNAS December 20, 2005 102 (51) 18757-18762; https://doi.org/10.1073/pnas.0509281102

• Medical Sciences

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    Three independent biological mechanisms cause exercise-associated hyponatremia: Evidence from 2,135 weighed competitive athletic performances

    T. D. Noakes, K. Sharwood, D. Speedy, T. Hew, S. Reid, J. Dugas, C. Almond, P. Wharam, and L. Weschler

    PNAS December 20, 2005 102 (51) 18550-18555; https://doi.org/10.1073/pnas.0509096102
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    Human cancers overexpress genes that are specific to a variety of normal human tissues

    Joseph Lotem, Dvir Netanely, Eytan Domany, and Leo Sachs

    PNAS December 20, 2005 102 (51) 18556-18561; https://doi.org/10.1073/pnas.0509360102
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    Epstein–Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase

    Jason S. Knight, Nikhil Sharma, and Erle S. Robertson

    PNAS December 20, 2005 102 (51) 18562-18566; https://doi.org/10.1073/pnas.0503886102
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    Repression of β-catenin function in malignant cells by nonsteroidal antiinflammatory drugs

    Desheng Lu, Howard B. Cottam, Maripat Corr, and Dennis A. Carson

    PNAS December 20, 2005 102 (51) 18567-18571; https://doi.org/10.1073/pnas.0509316102

• Microbiology

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    Poxvirus multiprotein entry–fusion complex

    Tatiana G. Senkevich, Suany Ojeda, Alan Townsley, Gretchen E. Nelson, and Bernard Moss

    PNAS December 20, 2005 102 (51) 18572-18577; https://doi.org/10.1073/pnas.0509239102
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    Bordetella filamentous hemagglutinin plays a critical role in immunomodulation, suggesting a mechanism for host specificity

    Carol S. Inatsuka, Steven M. Julio, and Peggy A. Cotter

    PNAS December 20, 2005 102 (51) 18578-18583; https://doi.org/10.1073/pnas.0507910102
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    Posttranslational conversion of l-serines to d-alanines is vital for optimal production and activity of the lantibiotic lacticin 3147

    Paul D. Cotter, Paula M. O'Connor, Lorraine A. Draper, Elaine M. Lawton, Lucy H. Deegan, Colin Hill, and R. Paul Ross

    PNAS December 20, 2005 102 (51) 18584-18589; https://doi.org/10.1073/pnas.0509371102
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    The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host

    G. Gabriel, B. Dauber, T. Wolff, O. Planz, H.-D. Klenk, and J. Stech

    PNAS December 20, 2005 102 (51) 18590-18595; https://doi.org/10.1073/pnas.0507415102
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    Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis

    Ke Shi, C. Kent Brown, Zu-Yi Gu, Briana K. Kozlowicz, Gary M. Dunny, Douglas H. Ohlendorf, and Cathleen A. Earhart

    PNAS December 20, 2005 102 (51) 18596-18601; https://doi.org/10.1073/pnas.0506163102
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    The cell-shape protein MreC interacts with extracytoplasmic proteins including cell wall assembly complexes in Caulobacter crescentus

    Arun V. Divakaruni, Rachel R. Ogorzalek Loo, Yongming Xie, Joseph A. Loo, and James W. Gober

    PNAS December 20, 2005 102 (51) 18602-18607; https://doi.org/10.1073/pnas.0507937102
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    Two independent spiral structures control cell shape in Caulobacter

    Natalie A. Dye, Zachary Pincus, Julie A. Theriot, Lucy Shapiro, and Zemer Gitai

    PNAS December 20, 2005 102 (51) 18608-18613; https://doi.org/10.1073/pnas.0507708102

• Neuroscience

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    Unexceptional sharpness of frequency tuning in the human cochlea

    Mario A. Ruggero and Andrei N. Temchin

    PNAS December 20, 2005 102 (51) 18614-18619; https://doi.org/10.1073/pnas.0509323102
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    Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis

    G. Gobbi, F. R. Bambico, R. Mangieri, M. Bortolato, P. Campolongo, M. Solinas, T. Cassano, M. G. Morgese, G. Debonnel, A. Duranti, A. Tontini, G. Tarzia, M. Mor, V. Trezza, S. R. Goldberg, V. Cuomo, and D. Piomelli

    PNAS December 20, 2005 102 (51) 18620-18625; https://doi.org/10.1073/pnas.0509591102
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    Control over brain activation and pain learned by using real-time functional MRI

    R. Christopher deCharms, Fumiko Maeda, Gary H. Glover, David Ludlow, John M. Pauly, Deepak Soneji, John D. E. Gabrieli, and Sean C. Mackey

    PNAS December 20, 2005 102 (51) 18626-18631; https://doi.org/10.1073/pnas.0505210102
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    Modulation of neuropeptide Y expression in adult mice does not affect feeding

    Linda Ste. Marie, Serge Luquet, Toby B. Cole, and Richard D. Palmiter

    PNAS December 20, 2005 102 (51) 18632-18637; https://doi.org/10.1073/pnas.0509240102
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    Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types

    Vikaas S. Sohal and John R. Huguenard

    PNAS December 20, 2005 102 (51) 18638-18643; https://doi.org/10.1073/pnas.0509291102
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    Development of functional human embryonic stem cell-derived neurons in mouse brain

    Alysson R. Muotri, Kinichi Nakashima, Nicolas Toni, Vladislav M. Sandler, and Fred H. Gage

    PNAS December 20, 2005 102 (51) 18644-18648; https://doi.org/10.1073/pnas.0509315102

    See companion article:

    • This Week in PNAS

      - Dec 20, 2005
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    The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal

    Angelo Contarino and Francesco Papaleo

    PNAS December 20, 2005 102 (51) 18649-18654; https://doi.org/10.1073/pnas.0506999102
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    Neurons of the cerebral cortex exhibit precise interspike timing in correspondence to behavior

    Tomer Shmiel, Rotem Drori, Oren Shmiel, Yoram Ben-Shaul, Zoltan Nadasdy, Moshe Shemesh, Mina Teicher, and Moshe Abeles

    PNAS December 20, 2005 102 (51) 18655-18657; https://doi.org/10.1073/pnas.0509346102
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    Recombinant human nerve growth factor with a marked activity in vitro and in vivo

    Anna M. Colangelo, Nicoletta Finotti, Michela Ceriani, Lilia Alberghina, Enzo Martegani, Luigi Aloe, Laura Lenzi, and Rita Levi-Montalcini

    PNAS December 20, 2005 102 (51) 18658-18663; https://doi.org/10.1073/pnas.0508734102
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    Augmenting neurotransmitter release by enhancing the apparent Ca²⁺ affinity of synaptotagmin 1

    J.-S. Rhee, L. Y. Li, O.-H. Shin, J.-C. Rah, J. Rizo, T. C. Südhof, and C. Rosenmund

    PNAS December 20, 2005 102 (51) 18664-18669; https://doi.org/10.1073/pnas.0509153102
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    Galactocerebrosidase-deficient oligodendrocytes maintain stable central myelin by exogenous replacement of the missing enzyme in mice

    • From the Cover

    Yoichi Kondo, David A. Wenger, Vittorio Gallo, and Ian D. Duncan

    PNAS December 20, 2005 102 (51) 18670-18675; https://doi.org/10.1073/pnas.0506473102
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    Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

    Wanli W. Smith, Zhong Pei, Haibing Jiang, Darren J. Moore, Yideng Liang, Andrew B. West, Valina L. Dawson, Ted M. Dawson, and Christopher A. Ross

    PNAS December 20, 2005 102 (51) 18676-18681; https://doi.org/10.1073/pnas.0508052102
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    Unconscious fear influences emotional awareness of faces and voices

    B. de Gelder, J. S. Morris, and R. J. Dolan

    PNAS December 20, 2005 102 (51) 18682-18687; https://doi.org/10.1073/pnas.0509179102
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    Beyond the olfactory bulb: An odotopic map in the forebrain

    Alexander A. Nikonov, Thomas E. Finger, and John Caprio

    PNAS December 20, 2005 102 (51) 18688-18693; https://doi.org/10.1073/pnas.0505241102
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    Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

    Shengjun Chang, Tian ran Ma, R. Dennis Miranda, Maureen E. Balestra, Robert W. Mahley, and Yadong Huang

    PNAS December 20, 2005 102 (51) 18694-18699; https://doi.org/10.1073/pnas.0508254102
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    Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target

    Shiming Ye, Yadong Huang, Karin Müllendorff, Liming Dong, Gretchen Giedt, Elaine C. Meng, Fred E. Cohen, Irwin D. Kuntz, Karl H. Weisgraber, and Robert W. Mahley

    PNAS December 20, 2005 102 (51) 18700-18705; https://doi.org/10.1073/pnas.0508693102

• Pharmacology

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    Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells

    Muriel Nobles, Amy Benians, and Andrew Tinker

    PNAS December 20, 2005 102 (51) 18706-18711; https://doi.org/10.1073/pnas.0504778102
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    A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo

    • From the Cover

    Kayo Mitsukawa, Rina Yamamoto, Silvio Ofner, Joachim Nozulak, Oliver Pescott, Snezana Lukic, Natacha Stoehr, Cedric Mombereau, Rainer Kuhn, Kevin H. McAllister, Herman van der Putten, John F. Cryan, and Peter J. Flor

    PNAS December 20, 2005 102 (51) 18712-18717; https://doi.org/10.1073/pnas.0508063102

• Physiology

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    Optical detection of rate-determining ion-modulated conformational changes of the ether-à-go-go K⁺ channel voltage sensor

    John P. A. Bannister, Baron Chanda, Francisco Bezanilla, and Diane M. Papazian

    PNAS December 20, 2005 102 (51) 18718-18723; https://doi.org/10.1073/pnas.0505766102
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    Gap junctional hemichannel-mediated ATP release and hearing controls in the inner ear

    Hong-Bo Zhao, Ning Yu, and Carrie R. Fleming

    PNAS December 20, 2005 102 (51) 18724-18729; https://doi.org/10.1073/pnas.0506481102

• Plant Biology

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    A regulator of nutritional copper signaling in Chlamydomonas is an SBP domain protein that recognizes the GTAC core of copper response element

    Janette Kropat, Stephen Tottey, Rainer P. Birkenbihl, Nathalie Depège, Peter Huijser, and Sabeeha Merchant

    PNAS December 20, 2005 102 (51) 18730-18735; https://doi.org/10.1073/pnas.0507693102
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    RHL1 is an essential component of the plant DNA topoisomerase VI complex and is required for ploidy-dependent cell growth

    Keiko Sugimoto-Shirasu, Gethin R. Roberts, Nicola J. Stacey, Maureen C. McCann, Anthony Maxwell, and Keith Roberts

    PNAS December 20, 2005 102 (51) 18736-18741; https://doi.org/10.1073/pnas.0505883102
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    Shoot circumnutation and winding movements require gravisensing cells

    • From the Cover

    Daisuke Kitazawa, Yasuko Hatakeda, Motoshi Kamada, Nobuharu Fujii, Yutaka Miyazawa, Atsushi Hoshino, Shigeru Iida, Hidehiro Fukaki, Miyo Terao Morita, Masao Tasaka, Hiroshi Suge, and Hideyuki Takahashi

    PNAS December 20, 2005 102 (51) 18742-18747; https://doi.org/10.1073/pnas.0504617102

    See companion article:

    • This Week in PNAS

      - Dec 20, 2005

• Psychology

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    Auditory-visual fusion in speech perception in children with cochlear implants

    Efrat A. Schorr, Nathan A. Fox, Virginie van Wassenhove, and Eric I. Knudsen

    PNAS December 20, 2005 102 (51) 18748-18750; https://doi.org/10.1073/pnas.0508862102
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    The spread of attention across modalities and space in a multisensory object

    Laura Busse, Kenneth C. Roberts, Roy E. Crist, Daniel H. Weissman, and Marty G. Woldorff

    PNAS December 20, 2005 102 (51) 18751-18756; https://doi.org/10.1073/pnas.0507704102