Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A

    Mark R. Proctor, Edward J. Taylor, Didier Nurizzo, Johan P. Turkenburg, Ruth M. Lloyd, Maria Vardakou, Gideon J. Davies, and Harry J. Gilbert

    PNAS February 22, 2005 102 (8) 2697-2702; https://doi.org/10.1073/pnas.0500051102

• Biochemistry

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    Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

    • From the Cover

    Koichi Okumura, Mujun Zhao, Ronald A. DePinho, Frank B. Furnari, and Webster K. Cavenee

    PNAS February 22, 2005 102 (8) 2703-2706; https://doi.org/10.1073/pnas.0409370102

    See companion article:

    • This Week in PNAS

      - Feb 22, 2005
    • Phosphatase and tensin homologue growth suppression without phosphatase

      - Feb 14, 2005
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    A critical role of helix 3–helix 5 interaction in steroid hormone receptor function

    Junhui Zhang, Jessica Simisky, Francis T. F. Tsai, and David S. Geller

    PNAS February 22, 2005 102 (8) 2707-2712; https://doi.org/10.1073/pnas.0409663102
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    Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin

    Jason F. Flores, Charles R. Fisher, Susan L. Carney, Brian N. Green, John K. Freytag, Stephen W. Schaeffer, and William E. Royer Jr.

    PNAS February 22, 2005 102 (8) 2713-2718; https://doi.org/10.1073/pnas.0407455102
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    Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor

    Elizabeth Buck and James A. Wells

    PNAS February 22, 2005 102 (8) 2719-2724; https://doi.org/10.1073/pnas.0500016102
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    Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions

    Tadashi Yamashita, Yun-Ping Wu, Roger Sandhoff, Norbert Werth, Hiroki Mizukami, Jessica M. Ellis, Jeffrey L. Dupree, Rudolf Geyer, Konrad Sandhoff, and Richard L. Proia

    PNAS February 22, 2005 102 (8) 2725-2730; https://doi.org/10.1073/pnas.0407785102
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    Inorganic polyphosphate in Dictyostelium discoideum: Influence on development, sporulation, and predation

    Haiyu Zhang, María R. Gómez-García, Michael R. W. Brown, and Arthur Kornberg

    PNAS February 22, 2005 102 (8) 2731-2735; https://doi.org/10.1073/pnas.0500023102

• Biophysics

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    Surviving heat shock: Control strategies for robustness and performance

    H. El-Samad, H. Kurata, J. C. Doyle, C. A. Gross, and M. Khammash

    PNAS February 22, 2005 102 (8) 2736-2741; https://doi.org/10.1073/pnas.0403510102

    See companion article:

    • Understanding biology by reverse engineering the control

      - Mar 14, 2005
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    The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path

    J. P. Johnson Jr. and William N. Zagotta

    PNAS February 22, 2005 102 (8) 2742-2747; https://doi.org/10.1073/pnas.0408323102
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    Specific collapse followed by slow hydrogen-bond formation of β-sheet in the folding of single-chain monellin

    Tetsunari Kimura, Takanori Uzawa, Koichiro Ishimori, Isao Morishima, Satoshi Takahashi, Takashi Konno, Shuji Akiyama, and Tetsuro Fujisawa

    PNAS February 22, 2005 102 (8) 2748-2753; https://doi.org/10.1073/pnas.0407982102
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    Polyproline and the “spectroscopic ruler” revisited with single-molecule fluorescence

    Benjamin Schuler, Everett A. Lipman, Peter J. Steinbach, Michael Kumke, and William A. Eaton

    PNAS February 22, 2005 102 (8) 2754-2759; https://doi.org/10.1073/pnas.0408164102

• Cell Biology

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    Clathrin-independent endocytosis of ubiquitinated cargos

    • From the Cover

    Sara Sigismund, Tanja Woelk, Claudia Puri, Elena Maspero, Carlo Tacchetti, Pietro Transidico, Pier Paolo Di Fiore, and Simona Polo

    PNAS February 22, 2005 102 (8) 2760-2765; https://doi.org/10.1073/pnas.0409817102

    See companion article:

    • Endocytosis of membrane receptors: Two pathways are better than one

      - Feb 14, 2005
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    The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin

    • From the Cover

    Hong Chen and Pietro De Camilli

    PNAS February 22, 2005 102 (8) 2766-2771; https://doi.org/10.1073/pnas.0409719102

    See companion article:

    • Endocytosis of membrane receptors: Two pathways are better than one

      - Feb 14, 2005
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    Cryo-electron tomography of vaccinia virus

    Marek Cyrklaff, Cristina Risco, Jose Jesús Fernández, Maria Victoria Jiménez, Mariano Estéban, Wolfgang Baumeister, and José L. Carrascosa

    PNAS February 22, 2005 102 (8) 2772-2777; https://doi.org/10.1073/pnas.0409825102
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    Nucleoplasmin regulates chromatin condensation during apoptosis

    Zhigang Lu, Chuanmao Zhang, and Zhonghe Zhai

    PNAS February 22, 2005 102 (8) 2778-2783; https://doi.org/10.1073/pnas.0405374102
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    Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70

    Kai-Feng Xu, Xiaoyan Shen, Hewang Li, Gustavo Pacheco-Rodriguez, Joel Moss, and Martha Vaughan

    PNAS February 22, 2005 102 (8) 2784-2789; https://doi.org/10.1073/pnas.0409871102
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    β-Arrestins bind and decrease cell-surface abundance of the Na⁺/H⁺ exchanger NHE5 isoform

    Elöd Z. Szabó, Masayuki Numata, Viktoria Lukashova, Pietro Iannuzzi, and John Orlowski

    PNAS February 22, 2005 102 (8) 2790-2795; https://doi.org/10.1073/pnas.0407444102
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    Mouse Na⁺/K⁺-ATPase β1-subunit has a K⁺-dependent cell adhesion activity for β-GlcNAc-terminating glycans

    Noriaki Kitamura, Masahiko Ikekita, Takeshi Sato, Yoshihiro Akimoto, Yasumaru Hatanaka, Hayato Kawakami, Mitsushi Inomata, and Kiyoshi Furukawa

    PNAS February 22, 2005 102 (8) 2796-2801; https://doi.org/10.1073/pnas.0409344102
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    Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis

    Qinghong Zhang, Amanda Nottke, and Richard H. Goodman

    PNAS February 22, 2005 102 (8) 2802-2807; https://doi.org/10.1073/pnas.0409373102

• Developmental Biology

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    Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis

    Igor Martianov, Stefano Brancorsini, Raffaella Catena, Anne Gansmuller, Noora Kotaja, Martti Parvinen, Paolo Sassone-Corsi, and Irwin Davidson

    PNAS February 22, 2005 102 (8) 2808-2813; https://doi.org/10.1073/pnas.0406060102
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    Early onset of puberty and early ovarian failure in CYP7B1 knockout mice

    Yoko Omoto, Richard Lathe, Margaret Warner, and Jan-Åke Gustafsson

    PNAS February 22, 2005 102 (8) 2814-2819; https://doi.org/10.1073/pnas.0500198102
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    Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2

    Ching-Wei Luo, Elizabeth M. Dewey, Satoko Sudo, John Ewer, Sheau Yu Hsu, Hans-Willi Honegger, and Aaron J. W. Hsueh

    PNAS February 22, 2005 102 (8) 2820-2825; https://doi.org/10.1073/pnas.0409916102

• Ecology

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    Ecosystem recovery after climatic extremes enhanced by genotypic diversity

    Thorsten B. H. Reusch, Anneli Ehlers, August Hämmerli, and Boris Worm

    PNAS February 22, 2005 102 (8) 2826-2831; https://doi.org/10.1073/pnas.0500008102

• Evolution

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    Positive selection of primate TRIM5α identifies a critical species-specific retroviral restriction domain

    Sara L. Sawyer, Lily I. Wu, Michael Emerman, and Harmit S. Malik

    PNAS February 22, 2005 102 (8) 2832-2837; https://doi.org/10.1073/pnas.0409853102

    See companion article:

    • The power of phylogenetic comparison in revealing protein function

      - Feb 22, 2005
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    Heritability and genetic constraints of life-history trait evolution in preindustrial humans

    Jenni E. Pettay, Loeske E. B. Kruuk, Jukka Jokela, and Virpi Lummaa

    PNAS February 22, 2005 102 (8) 2838-2843; https://doi.org/10.1073/pnas.0406709102
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    Synthesis and degradation of dinoflagellate plastid-encoded psbA proteins are light-regulated, not circadian-regulated

    Yunling Wang, Lene Jensen, Peter Højrup, and David Morse

    PNAS February 22, 2005 102 (8) 2844-2849; https://doi.org/10.1073/pnas.0406522102

• Genetics

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    Uncovering transcriptional regulation of metabolism by using metabolic network topology

    Kiran Raosaheb Patil and Jens Nielsen

    PNAS February 22, 2005 102 (8) 2685-2689; https://doi.org/10.1073/pnas.0406811102
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    Identification and analysis of alternative splicing events conserved in human and mouse

    Gene W. Yeo, Eric Van Nostrand, Dirk Holste, Tomaso Poggio, and Christopher B. Burge

    PNAS February 22, 2005 102 (8) 2850-2855; https://doi.org/10.1073/pnas.0409742102
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    Multiple homeostatic mechanisms in the control of P1 plasmid replication

    Nilangshu Das, Majda Valjavec-Gratian, Ashish N. Basuray, Richard A. Fekete, Peter P. Papp, Johan Paulsson, and Dhruba K. Chattoraj

    PNAS February 22, 2005 102 (8) 2856-2861; https://doi.org/10.1073/pnas.0409790102
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    Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica

    Igor Zwir, Dongwoo Shin, Akinori Kato, Kunihiko Nishino, Tammy Latifi, Felix Solomon, Janelle M. Hare, Henry Huang, and Eduardo A. Groisman

    PNAS February 22, 2005 102 (8) 2862-2867; https://doi.org/10.1073/pnas.0408238102
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    Genetic basis of variation in adenoma multiplicity in Apc^Min/+Mom1^S mice

    Jackie Haines, Victoria Johnson, Kevin Pack, Nirosha Suraweera, Predrag Slijepcevic, Erik Cabuy, Margaret Coster, Mohammad Ilyas, Jennifer Wilding, Oliver Sieber, Walter Bodmer, Ian Tomlinson, and Andrew Silver

    PNAS February 22, 2005 102 (8) 2868-2873; https://doi.org/10.1073/pnas.0500039102

• Immunology

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    TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs

    Julia Hauer, Stephanie Püschner, Parameswaran Ramakrishnan, Ute Simon, Martina Bongers, Christine Federle, and Hartmut Engelmann

    PNAS February 22, 2005 102 (8) 2874-2879; https://doi.org/10.1073/pnas.0500187102
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    Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization

    Mansour Mohamadzadeh, Scott Olson, Warren V. Kalina, Gordon Ruthel, Gretchen L. Demmin, Kelly L. Warfield, Sina Bavari, and Todd R. Klaenhammer

    PNAS February 22, 2005 102 (8) 2880-2885; https://doi.org/10.1073/pnas.0500098102
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    Characterization of CD56^–/CD16⁺ natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals

    Domenico Mavilio, Gabriella Lombardo, Janet Benjamin, Diana Kim, Dean Follman, Emanuela Marcenaro, M. Angeline O'Shea, Audrey Kinter, Colin Kovacs, Alessandro Moretta, and Anthony S. Fauci

    PNAS February 22, 2005 102 (8) 2886-2891; https://doi.org/10.1073/pnas.0409872102
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    The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles

    Jörg H. W. Distler, Astrid Jüngel, Lars C. Huber, Christian A. Seemayer, Charles F. Reich III, Renate E. Gay, Beat A. Michel, Adriano Fontana, Steffen Gay, David S. Pisetsky, and Oliver Distler

    PNAS February 22, 2005 102 (8) 2892-2897; https://doi.org/10.1073/pnas.0409781102
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    T cells from epicutaneously immunized mice are prone to T cell receptor revision

    Margaret S. Bynoe, Christophe Viret, Richard A. Flavell, and Charles A. Janeway Jr.

    PNAS February 22, 2005 102 (8) 2898-2903; https://doi.org/10.1073/pnas.0409880102
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    T cell receptor (TCR) clustering in the immunological synapse integrates TCR and costimulatory signaling in selected T cells

    Bozidar Purtic, Lisa A. Pitcher, Nicolai S. C. van Oers, and Christoph Wülfing

    PNAS February 22, 2005 102 (8) 2904-2909; https://doi.org/10.1073/pnas.0406867102
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    Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells

    Kavita M. Dhodapkar, Jacob L. Kaufman, Marc Ehlers, Devi K. Banerjee, Ezio Bonvini, Scott Koenig, Ralph M. Steinman, Jeffrey V. Ravetch, and Madhav V. Dhodapkar

    PNAS February 22, 2005 102 (8) 2910-2915; https://doi.org/10.1073/pnas.0500014102

• Medical Sciences

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    Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats

    Tammara Watts, Irene Berti, Anna Sapone, Tania Gerarduzzi, Tarcisio Not, Ronald Zielke, and Alessio Fasano

    PNAS February 22, 2005 102 (8) 2916-2921; https://doi.org/10.1073/pnas.0500178102
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    Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging

    P. Peter Ghoroghchian, Paul R. Frail, Kimihiro Susumu, Dana Blessington, Aaron K. Brannan, Frank S. Bates, Britton Chance, Daniel A. Hammer, and Michael J. Therien

    PNAS February 22, 2005 102 (8) 2922-2927; https://doi.org/10.1073/pnas.0409394102
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    Embryonic pig liver, pancreas, and lung as a source for transplantation: Optimal organogenesis without teratoma depends on distinct time windows

    Smadar Eventov-Friedman, Helena Katchman, Elias Shezen, Anna Aronovich, Dalit Tchorsh, Benjamin Dekel, Enrique Freud, and Yair Reisner

    PNAS February 22, 2005 102 (8) 2928-2933; https://doi.org/10.1073/pnas.0500177102
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    Function of endogenous inhibitors of angiogenesis as endothelium-specific tumor suppressors

    Malin Sund, Yuki Hamano, Hikaru Sugimoto, Akulapalli Sudhakar, Mary Soubasakos, Udaya Yerramalla, Laura E. Benjamin, Jack Lawler, Mark Kieran, Amish Shah, and Raghu Kalluri

    PNAS February 22, 2005 102 (8) 2934-2939; https://doi.org/10.1073/pnas.0500180102
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    Vaccinia viruses with a serpin gene deletion and expressing IFN-γ induce potent immune responses without detectable replication in vivo

    Fatema A. Legrand, Paulo H. Verardi, Kenneth S. Chan, Yue Peng, Leslie A. Jones, and Tilahun D. Yilma

    PNAS February 22, 2005 102 (8) 2940-2945; https://doi.org/10.1073/pnas.0409846102
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    Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration

    Jeffrey A. Spencer, Shelby L. Hacker, Elaine C. Davis, Robert P. Mecham, Russ H. Knutsen, Dean Y. Li, Robert D. Gerard, James A. Richardson, Eric N. Olson, and Hiromi Yanagisawa

    PNAS February 22, 2005 102 (8) 2946-2951; https://doi.org/10.1073/pnas.0500058102
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    A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia

    Lynda S. Ostedgaard, Tatiana Rokhlina, Philip H. Karp, Philip Lashmit, Sandra Afione, Michael Schmidt, Joseph Zabner, Mark F. Stinski, Jay A. Chiorini, and Michael J. Welsh

    PNAS February 22, 2005 102 (8) 2952-2957; https://doi.org/10.1073/pnas.0409845102
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    Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro

    Jeffrey H. Fair, Bruce A. Cairns, Michael A. LaPaglia, Montserrat Caballero, W. Andrew Pleasant, Seigo Hatada, Hyung-suk Kim, Tong Gui, Larysa Pevny, Anthony A. Meyer, Darrel W. Stafford, Oliver Smithies, and Jeffrey A. Frelinger

    PNAS February 22, 2005 102 (8) 2958-2963; https://doi.org/10.1073/pnas.0409840102
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    Karyotypic “state” as a potential determinant for anticancer drug discovery

    Anna V. Roschke, Samir Lababidi, Giovanni Tonon, Kristen S. Gehlhaus, Kimberly Bussey, John N. Weinstein, and Ilan R. Kirsch

    PNAS February 22, 2005 102 (8) 2964-2969; https://doi.org/10.1073/pnas.0405578102
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    Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice

    Naoko Niho, Michihiro Mutoh, Mami Takahashi, Kazuhiko Tsutsumi, Takashi Sugimura, and Keiji Wakabayashi

    PNAS February 22, 2005 102 (8) 2970-2974; https://doi.org/10.1073/pnas.0500153102
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    Syndromic patent ductus arteriosus: Evidence for haploinsufficient TFAP2B mutations and identification of a linked sleep disorder

    Arya Mani, Jayaram Radhakrishnan, Anita Farhi, Khary S. Carew, Carole A. Warnes, Carol Nelson-Williams, Ronald W. Day, Barbara Pober, Matthew W. State, and Richard P. Lifton

    PNAS February 22, 2005 102 (8) 2975-2979; https://doi.org/10.1073/pnas.0409852102

• Microbiology

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    Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators

    Markus Meissner, Efrosinia Krejany, Paul R. Gilson, Tania F. de Koning-Ward, Dominique Soldati, and Brendan S. Crabb

    PNAS February 22, 2005 102 (8) 2980-2985; https://doi.org/10.1073/pnas.0500112102
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    Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling

    Eileen Foy, Kui Li, Rhea Sumpter Jr., Yueh-Ming Loo, Cynthia L. Johnson, Chunfu Wang, Penny Mar Fish, Mitsutoshi Yoneyama, Takashi Fujita, Stanley M. Lemon, and Michael Gale Jr.

    PNAS February 22, 2005 102 (8) 2986-2991; https://doi.org/10.1073/pnas.0408707102
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    Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

    Kui Li, Eileen Foy, Josephine C. Ferreon, Mitsuyasu Nakamura, Allan C. M. Ferreon, Masanori Ikeda, Stuart C. Ray, Michael Gale Jr., and Stanley M. Lemon

    PNAS February 22, 2005 102 (8) 2992-2997; https://doi.org/10.1073/pnas.0408824102
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    Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein

    Angela R. Brannon, Julia A. Maresca, Jef D. Boeke, Munira A. Basrai, and Alison A. McBride

    PNAS February 22, 2005 102 (8) 2998-3003; https://doi.org/10.1073/pnas.0407818102
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    Complete genome sequence of Vibrio fischeri: A symbiotic bacterium with pathogenic congeners

    E. G. Ruby, M. Urbanowski, J. Campbell, A. Dunn, M. Faini, R. Gunsalus, P. Lostroh, C. Lupp, J. McCann, D. Millikan, A. Schaefer, E. Stabb, A. Stevens, K. Visick, C. Whistler, and E. P. Greenberg

    PNAS February 22, 2005 102 (8) 3004-3009; https://doi.org/10.1073/pnas.0409900102

    See companion article:

    • This Week in PNAS

      - Feb 22, 2005
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    Enhancer-binding proteins with a forkhead-associated domain and the σ⁵⁴ regulon in Myxococcus xanthus fruiting body development

    Lars Jelsbak, Michael Givskov, and Dale Kaiser

    PNAS February 22, 2005 102 (8) 3010-3015; https://doi.org/10.1073/pnas.0409371102

    See companion article:

    • Eukaryotic-like signaling and gene regulation in a prokaryote that undergoes multicellular development

      - Feb 14, 2005
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    Engineering N-linked protein glycosylation with diverse O antigen lipopolysaccharide structures in Escherichia coli

    Mario F. Feldman, Michael Wacker, Marcela Hernandez, Paul G. Hitchen, Cristina L. Marolda, Michael Kowarik, Howard R. Morris, Anne Dell, Miguel A. Valvano, and Markus Aebi

    PNAS February 22, 2005 102 (8) 3016-3021; https://doi.org/10.1073/pnas.0500044102
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    Plasmodium liver stage developmental arrest by depletion of a protein at the parasite–host interface

    Ann-Kristin Mueller, Nelly Camargo, Karine Kaiser, Cathy Andorfer, Ute Frevert, Kai Matuschewski, and Stefan H. I. Kappe

    PNAS February 22, 2005 102 (8) 3022-3027; https://doi.org/10.1073/pnas.0408442102
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    Bile acids induce cholera toxin expression in Vibrio cholerae in a ToxT-independent manner

    Deborah T. Hung and John J. Mekalanos

    PNAS February 22, 2005 102 (8) 3028-3033; https://doi.org/10.1073/pnas.0409559102

• Neuroscience

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    β-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids

    Amyaouch Bradaïa, Frédérique Berton, Serge Ferrari, and Christian Lüscher

    PNAS February 22, 2005 102 (8) 3034-3039; https://doi.org/10.1073/pnas.0406632102
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    Honey bees navigate according to a map-like spatial memory

    Randolf Menzel, Uwe Greggers, Alan Smith, Sandra Berger, Robert Brandt, Sascha Brunke, Gesine Bundrock, Sandra Hülse, Tobias Plümpe, Frank Schaupp, Elke Schüttler, Silke Stach, Jan Stindt, Nicola Stollhoff, and Sebastian Watzl

    PNAS February 22, 2005 102 (8) 3040-3045; https://doi.org/10.1073/pnas.0408550102
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    Chronic nicotine administration exacerbates tau pathology in a transgenic model of Alzheimer's disease

    Salvatore Oddo, Antonella Caccamo, Kim N. Green, Kevin Liang, Levina Tran, Yiling Chen, Frances M. Leslie, and Frank M. LaFerla

    PNAS February 22, 2005 102 (8) 3046-3051; https://doi.org/10.1073/pnas.0408500102
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    Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain

    Takayoshi Ubuka, George E. Bentley, Kazuyoshi Ukena, John C. Wingfield, and Kazuyoshi Tsutsui

    PNAS February 22, 2005 102 (8) 3052-3057; https://doi.org/10.1073/pnas.0403840102
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    Amyloid-β neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity

    Nikolay L. Malinin, Sarah Wright, Peter Seubert, Dale Schenk, and Irene Griswold-Prenner

    PNAS February 22, 2005 102 (8) 3058-3063; https://doi.org/10.1073/pnas.0408237102
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    Transcellular induction of neuropeptide Y expression by NT4 and BDNF

    Marcus J. Wirth, Silke Patz, and Petra Wahle

    PNAS February 22, 2005 102 (8) 3064-3069; https://doi.org/10.1073/pnas.0404712102
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    Cognitive deficit associated with cholinergic and nerve growth factor down-regulation in experimental allergic encephalomyelitis in rats

    Giulia D'Intino, Michela Paradisi, Mercedes Fernandez, Alessandro Giuliani, Luigi Aloe, Luciana Giardino, and Laura Calzà

    PNAS February 22, 2005 102 (8) 3070-3075; https://doi.org/10.1073/pnas.0500073102
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    Shared and specific muscle synergies in natural motor behaviors

    Andrea d'Avella and Emilio Bizzi

    PNAS February 22, 2005 102 (8) 3076-3081; https://doi.org/10.1073/pnas.0500199102

• Pharmacology

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    Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: Modes of ligand binding and dimerization

    Sergio E. Martinez, Sandra Bruder, Anita Schultz, Ning Zheng, Joachim E. Schultz, Joseph A. Beavo, and Jürgen U. Linder

    PNAS February 22, 2005 102 (8) 3082-3087; https://doi.org/10.1073/pnas.0409913102
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    The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites

    Sandra Bruder, Jürgen U. Linder, Sergio E. Martinez, Ning Zheng, Joseph A. Beavo, and Joachim E. Schultz

    PNAS February 22, 2005 102 (8) 3088-3092; https://doi.org/10.1073/pnas.0409917102
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    CB₂ cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

    Mohab M. Ibrahim, Frank Porreca, Josephine Lai, Phillip J. Albrecht, Frank L. Rice, Alla Khodorova, Gudarz Davar, Alexandros Makriyannis, Todd W. Vanderah, Heriberto P. Mata, and T. Philip Malan Jr.

    PNAS February 22, 2005 102 (8) 3093-3098; https://doi.org/10.1073/pnas.0409888102

    See companion article:

    • This Week in PNAS

      - Feb 22, 2005

• Physiology

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    Ca²⁺ blinks: Rapid nanoscopic store calcium signaling

    Didier X. P. Brochet, Dongmei Yang, Alessandro Di Maio, W. Jonathan Lederer, Clara Franzini-Armstrong, and Heping Cheng

    PNAS February 22, 2005 102 (8) 3099-3104; https://doi.org/10.1073/pnas.0500059102
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    Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands

    Susan J. Broughton, Matthew D. W. Piper, Tomoatsu Ikeya, Timothy M. Bass, Jake Jacobson, Yasmine Driege, Pedro Martinez, Ernst Hafen, Dominic J. Withers, Sally J. Leevers, and Linda Partridge

    PNAS February 22, 2005 102 (8) 3105-3110; https://doi.org/10.1073/pnas.0405775102
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    Differential control of peripheral circadian rhythms by suprachiasmatic-dependent neural signals

    Hongnian Guo, Judy McKinley Brewer, Ameya Champhekar, Ruth B. S. Harris, and Eric L. Bittman

    PNAS February 22, 2005 102 (8) 3111-3116; https://doi.org/10.1073/pnas.0409734102

    See companion article:

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      - Feb 22, 2005

• Plant Biology

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    Control of seed mass and seed yield by the floral homeotic gene APETALA2

    K. Diane Jofuku, Pamela K. Omidyar, Zorana Gee, and Jack K. Okamuro

    PNAS February 22, 2005 102 (8) 3117-3122; https://doi.org/10.1073/pnas.0409893102
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    Control of seed mass by APETALA2

    Masa-aki Ohto, Robert L. Fischer, Robert B. Goldberg, Kenzo Nakamura, and John J. Harada

    PNAS February 22, 2005 102 (8) 3123-3128; https://doi.org/10.1073/pnas.0409858102
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    Genetic and chemical analyses of the action mechanisms of sirtinol in Arabidopsis

    Xinhua Dai, Ken-ichiro Hayashi, Hiroshi Nozaki, Youfa Cheng, and Yunde Zhao

    PNAS February 22, 2005 102 (8) 3129-3134; https://doi.org/10.1073/pnas.0500185102
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    Recruitment and interaction dynamics of plant penetration resistance components in a plasma membrane microdomain

    Riyaz A. Bhat, Marco Miklis, Elmon Schmelzer, Paul Schulze-Lefert, and Ralph Panstruga

    PNAS February 22, 2005 102 (8) 3135-3140; https://doi.org/10.1073/pnas.0500012102

    See companion article:

    • This Week in PNAS

      - Feb 22, 2005
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    Antioxidants and photoprotection in a lichen as compared with its isolated symbiotic partners

    Ilse Kranner, W. John Cram, Margret Zorn, Sabine Wornik, Isao Yoshimura, Edith Stabentheiner, and Hartwig W. Pfeifhofer

    PNAS February 22, 2005 102 (8) 3141-3146; https://doi.org/10.1073/pnas.0407716102
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    Root-knot nematodes and bacterial Nod factors elicit common signal transduction events in Lotus japonicus

    Ravisha R. Weerasinghe, David McK. Bird, and Nina S. Allen

    PNAS February 22, 2005 102 (8) 3147-3152; https://doi.org/10.1073/pnas.0407926102

• Population Biology

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    Strategic interactions in multi-institutional epidemics of antibiotic resistance

    • From the Cover

    David L. Smith, Simon A. Levin, and Ramanan Laxminarayan

    PNAS February 22, 2005 102 (8) 3153-3158; https://doi.org/10.1073/pnas.0409523102

    See companion article:

    • The community-wide dilemma of hospital-acquired drug resistance

      - Feb 14, 2005

• Psychology

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    Symmetry activates extrastriate visual cortex in human and nonhuman primates

    Yuka Sasaki, Wim Vanduffel, Tamara Knutsen, Christopher Tyler, and Roger Tootell

    PNAS February 22, 2005 102 (8) 3159-3163; https://doi.org/10.1073/pnas.0500319102
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    Past trials influence perception of ambiguous motion quartets through pattern completion

    L. T. Maloney, M. F. Dal Martello, C. Sahm, and L. Spillmann

    PNAS February 22, 2005 102 (8) 3164-3169; https://doi.org/10.1073/pnas.0407157102