Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Mullerian inhibiting substance suppresses tumor growth in the C3(1)T antigen transgenic mouse mammary carcinoma model

    V. Gupta, J. L. Carey, H. Kawakubo, A. Muzikansky, J. E. Green, P. K. Donahoe, D. T. MacLaughlin, and S. Maheswaran

    PNAS March 1, 2005 102 (9) 3219-3224; https://doi.org/10.1073/pnas.0409709102

• Biochemistry

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    Structure of a mitochondrial supercomplex formed by respiratory-chain complexes I and III

    Natalia V. Dudkina, Holger Eubel, Wilko Keegstra, Egbert J. Boekema, and Hans-Peter Braun

    PNAS March 1, 2005 102 (9) 3225-3229; https://doi.org/10.1073/pnas.0408870102
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    The initial substrate-binding site of γ-secretase is located on presenilin near the active site

    Anna Y. Kornilova, Frédéric Bihel, Chittaranjan Das, and Michael S. Wolfe

    PNAS March 1, 2005 102 (9) 3230-3235; https://doi.org/10.1073/pnas.0407640102

    See companion article:

    • This Week in PNAS

      - Mar 01, 2005
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    Identification of a nitrogenase FeMo cofactor precursor on NifEN complex

    Yilin Hu, Aaron W. Fay, and Markus W. Ribbe

    PNAS March 1, 2005 102 (9) 3236-3241; https://doi.org/10.1073/pnas.0409201102
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    Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

    Jamison D. Feramisco, Arun Radhakrishnan, Yukio Ikeda, Julian Reitz, Michael S. Brown, and Joseph L. Goldstein

    PNAS March 1, 2005 102 (9) 3242-3247; https://doi.org/10.1073/pnas.0500206102
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    Crystal structure of DNA sequence specificity subunit of a type I restriction-modification enzyme and its functional implications

    Jeong-Sun Kim, Andy DeGiovanni, Jaru Jancarik, Paul D. Adams, Hisao Yokota, Rosalind Kim, and Sung-Hou Kim

    PNAS March 1, 2005 102 (9) 3248-3253; https://doi.org/10.1073/pnas.0409851102
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    Assembly of the bacteriophage T4 primosome: Single-molecule and ensemble studies

    Zhiquan Zhang, Michelle M. Spiering, Michael A. Trakselis, Faoud T. Ishmael, Jun Xi, Stephen J. Benkovic, and Gordon G. Hammes

    PNAS March 1, 2005 102 (9) 3254-3259; https://doi.org/10.1073/pnas.0500327102
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    Study of the high-potential iron sulfur protein in Halorhodospira halophila confirms that it is distinct from cytochrome c as electron carrier

    Clément Lieutaud, Jean Alric, Marielle Bauzan, Wolfgang Nitschke, and Barbara Schoepp-Cothenet

    PNAS March 1, 2005 102 (9) 3260-3265; https://doi.org/10.1073/pnas.0407768102
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    The eukaryotic P loop NTPase Nbp35: An essential component of the cytosolic and nuclear iron–sulfur protein assembly machinery

    Anja Hausmann, Daili J. Aguilar Netz, Janneke Balk, Antonio J. Pierik, Ulrich Mühlenhoff, and Roland Lill

    PNAS March 1, 2005 102 (9) 3266-3271; https://doi.org/10.1073/pnas.0406447102
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    Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes

    • From the Cover

    Kirsten Bacia, Petra Schwille, and Teymuras Kurzchalia

    PNAS March 1, 2005 102 (9) 3272-3277; https://doi.org/10.1073/pnas.0408215102

• Biophysics

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    Label-free detection of small-molecule–protein interactions by using nanowire nanosensors

    Wayne U. Wang, Chuo Chen, Keng-hui Lin, Ying Fang, and Charles M. Lieber

    PNAS March 1, 2005 102 (9) 3208-3212; https://doi.org/10.1073/pnas.0406368102
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    Growth and shape stability of a biological membrane adhesion complex in the diffusion-mediated regime

    V. B. Shenoy and L. B. Freund

    PNAS March 1, 2005 102 (9) 3213-3218; https://doi.org/10.1073/pnas.0500368102
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    Fast, long-range, reversible conformational fluctuations in nucleosomes revealed by single-pair fluorescence resonance energy transfer

    Miroslav Tomschik, Haocheng Zheng, Ken van Holde, Jordanka Zlatanova, and Sanford H. Leuba

    PNAS March 1, 2005 102 (9) 3278-3283; https://doi.org/10.1073/pnas.0500189102
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    Probing site-specific conformational distributions in protein folding with solid-state NMR

    Robert H. Havlin and Robert Tycko

    PNAS March 1, 2005 102 (9) 3284-3289; https://doi.org/10.1073/pnas.0406130102

• Cell Biology

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    Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina

    Ayelet Margalit, Miriam Segura-Totten, Yosef Gruenbaum, and Katherine L. Wilson

    PNAS March 1, 2005 102 (9) 3290-3295; https://doi.org/10.1073/pnas.0408364102
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    Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues

    Takashi Yokoo, Toya Ohashi, Jin Song Shen, Ken Sakurai, Yoichi Miyazaki, Yasunori Utsunomiya, Masanori Takahashi, Yoshio Terada, Yoshikatsu Eto, Tetsuya Kawamura, Noriko Osumi, and Tatsuo Hosoya

    PNAS March 1, 2005 102 (9) 3296-3300; https://doi.org/10.1073/pnas.0406878102
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    Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4)

    Dusanka Deretic, Andrew H. Williams, Nancy Ransom, Valerie Morel, Paul A. Hargrave, and Anatol Arendt

    PNAS March 1, 2005 102 (9) 3301-3306; https://doi.org/10.1073/pnas.0500095102
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    Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel

    Eda Yildirim, Brian T. Kawasaki, and Lutz Birnbaumer

    PNAS March 1, 2005 102 (9) 3307-3311; https://doi.org/10.1073/pnas.0409908102

• Developmental Biology

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    Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal

    Toshiyuki Yamane, Scott J. Dylla, Manja Muijtjens, and Irving L. Weissman

    PNAS March 1, 2005 102 (9) 3312-3317; https://doi.org/10.1073/pnas.0500167102
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    Mechanical feedback as a possible regulator of tissue growth

    Boris I. Shraiman

    PNAS March 1, 2005 102 (9) 3318-3323; https://doi.org/10.1073/pnas.0404782102
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    Regulation of osteoblastogenesis and bone mass by Wnt10b

    Christina N. Bennett, Kenneth A. Longo, Wendy S. Wright, Larry J. Suva, Timothy F. Lane, Kurt D. Hankenson, and Ormond A. MacDougald

    PNAS March 1, 2005 102 (9) 3324-3329; https://doi.org/10.1073/pnas.0408742102

• Evolution

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    Juvenile hormone, reproduction, and worker behavior in the neotropical social wasp Polistes canadensis

    Tugrul Giray, Manuela Giovanetti, and Mary Jane West-Eberhard

    PNAS March 1, 2005 102 (9) 3330-3335; https://doi.org/10.1073/pnas.0409560102

• Genetics

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    Association of tissue-specific differentially methylated regions (TDMs) with differential gene expression

    Fei Song, Joseph F. Smith, Makoto T. Kimura, Arlene D. Morrow, Tomoki Matsuyama, Hiroki Nagase, and William A. Held

    PNAS March 1, 2005 102 (9) 3336-3341; https://doi.org/10.1073/pnas.0408436102
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    Mutations in Serac1 or Synj2 cause proximal t haplotype-mediated male mouse sterility but not transmission ratio distortion

    John C. Schimenti, Jennifer L. Reynolds, and Antonio Planchart

    PNAS March 1, 2005 102 (9) 3342-3347; https://doi.org/10.1073/pnas.0407970102
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    Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactis

    Zeki Topcu, Kristy Nickles, Charity Davis, and Michael J. McEachern

    PNAS March 1, 2005 102 (9) 3348-3353; https://doi.org/10.1073/pnas.0408770102
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    Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes

    Elliott H. Margulies, NISC Comparative Sequencing Program* † ‡ , Valerie V. B. Maduro, Pamela J. Thomas, Jeffery P. Tomkins, Chris T. Amemiya, Meizhong Luo, and Eric D. Green

    PNAS March 1, 2005 102 (9) 3354-3359; https://doi.org/10.1073/pnas.0408539102

• Immunology

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    Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal–maternal interface

    Craig S. Clements, Lars Kjer-Nielsen, Lyudmila Kostenko, Hilary L. Hoare, Michelle A. Dunstone, Eric Moses, Katy Freed, Andrew G. Brooks, Jamie Rossjohn, and James McCluskey

    PNAS March 1, 2005 102 (9) 3360-3365; https://doi.org/10.1073/pnas.0409676102

    See companion article:

    • This Week in PNAS

      - Mar 01, 2005
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    An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin α_Lβ₂

    Gang Song, Yuting Yang, Jin-huan Liu, Jose M. Casasnovas, Motomu Shimaoka, Timothy A. Springer, and Jia-huai Wang

    PNAS March 1, 2005 102 (9) 3366-3371; https://doi.org/10.1073/pnas.0500200102
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    Cross-regulation of TNF and IFN-α in autoimmune diseases

    A. Karolina Palucka, Jean-Philippe Blanck, Lynda Bennett, Virginia Pascual, and Jacques Banchereau

    PNAS March 1, 2005 102 (9) 3372-3377; https://doi.org/10.1073/pnas.0408506102
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    Immunogenicity in humans of an edible vaccine for hepatitis B

    Yasmin Thanavala, Martin Mahoney, Sribani Pal, Adrienne Scott, Liz Richter, Nachimuthu Natarajan, Patti Goodwin, Charles J. Arntzen, and Hugh S. Mason

    PNAS March 1, 2005 102 (9) 3378-3382; https://doi.org/10.1073/pnas.0409899102
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    Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides

    Karl O. A. Yu, Jin S. Im, Alberto Molano, Yves Dutronc, Petr A. Illarionov, Claire Forestier, Nagatoshi Fujiwara, Isa Arias, Sachiko Miyake, Takashi Yamamura, Young-Tae Chang, Gurdyal S. Besra, and Steven A. Porcelli

    PNAS March 1, 2005 102 (9) 3383-3388; https://doi.org/10.1073/pnas.0407488102

• Medical Sciences

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    Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma

    Jean S. Campbell, Steven D. Hughes, Debra G. Gilbertson, Thomas E. Palmer, Matthew S. Holdren, Aaron C. Haran, Melissa M. Odell, Renay L. Bauer, Hong-Ping Ren, Harald S. Haugen, Matthew M. Yeh, and Nelson Fausto

    PNAS March 1, 2005 102 (9) 3389-3394; https://doi.org/10.1073/pnas.0409722102
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    Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

    Michael R. Burgess, Brian J. Skaggs, Neil P. Shah, Francis Y. Lee, and Charles L. Sawyers

    PNAS March 1, 2005 102 (9) 3395-3400; https://doi.org/10.1073/pnas.0409770102
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    Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis

    Timothy P. Dalton, Lei He, Bin Wang, Marian L. Miller, Li Jin, Keith F. Stringer, Xiaoqing Chang, C. Stuart Baxter, and Daniel W. Nebert

    PNAS March 1, 2005 102 (9) 3401-3406; https://doi.org/10.1073/pnas.0406085102
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    Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

    • From the Cover

    Victoria Y. Gorbacheva, Roman V. Kondratov, Renliang Zhang, Srujana Cherukuri, Andrei V. Gudkov, Joseph S. Takahashi, and Marina P. Antoch

    PNAS March 1, 2005 102 (9) 3407-3412; https://doi.org/10.1073/pnas.0409897102

    See companion article:

    • Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide

      - Feb 28, 2005
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    Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein

    Francesco Fornai, Oliver M. Schlüter, Paola Lenzi, Marco Gesi, Riccardo Ruffoli, Michela Ferrucci, Gloria Lazzeri, Carla L. Busceti, Fabrizio Pontarelli, Giuseppe Battaglia, Antonio Pellegrini, Ferdinando Nicoletti, Stefano Ruggieri, Antonio Paparelli, and Thomas C. Südhof

    PNAS March 1, 2005 102 (9) 3413-3418; https://doi.org/10.1073/pnas.0409713102
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    Microcomputed tomography colonography for polyp detection in an in vivo mouse tumor model

    Perry J. Pickhardt, Richard B. Halberg, Andrew J. Taylor, Ben Y. Durkee, Jason Fine, Fred T. Lee Jr., and Jamey P. Weichert

    PNAS March 1, 2005 102 (9) 3419-3422; https://doi.org/10.1073/pnas.0409915102
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    Circulating transcriptome reveals markers of atherosclerosis

    Willmar D. Patino, Omar Y. Mian, Ju-Gyeong Kang, Satoaki Matoba, Linda D. Bartlett, Brenda Holbrook, Hugh H. Trout III, Louis Kozloff, and Paul M. Hwang

    PNAS March 1, 2005 102 (9) 3423-3428; https://doi.org/10.1073/pnas.0408032102
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    Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfaces

    Adam J. Ratner, Elena S. Lysenko, Marina N. Paul, and Jeffrey N. Weiser

    PNAS March 1, 2005 102 (9) 3429-3434; https://doi.org/10.1073/pnas.0500599102
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    Antagonist of growth hormone-releasing hormone induces apoptosis in LNCaP human prostate cancer cells through a Ca²⁺-dependent pathway

    Zoltan Rekasi, Tamas Czompoly, Andrew V. Schally, Ferenc Boldizsar, Jozsef L. Varga, Marta Zarandi, Timea Berki, Reka A. Horvath, and Peter Nemeth

    PNAS March 1, 2005 102 (9) 3435-3440; https://doi.org/10.1073/pnas.0410006102

• Microbiology

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    Genome trimming: A unique strategy for replication control employed by Borna disease virus

    Urs Schneider, Martin Schwemmle, and Peter Staeheli

    PNAS March 1, 2005 102 (9) 3441-3446; https://doi.org/10.1073/pnas.0405965102
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    Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo

    Jan Rupp, Thomas Hellwig-Burgel, Viola Wobbe, Ulrike Seitzer, Ernst Brandt, and Matthias Maass

    PNAS March 1, 2005 102 (9) 3447-3452; https://doi.org/10.1073/pnas.0407759102
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    Lessons from Escherichia coli genes similarly regulated in response to nitrogen and sulfur limitation

    Prasad Gyaneshwar, Oleg Paliy, Jon McAuliffe, Adriane Jones, Michael I. Jordan, and Sydney Kustu

    PNAS March 1, 2005 102 (9) 3453-3458; https://doi.org/10.1073/pnas.0500141102
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    Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii

    • From the Cover

    Changbin Chen and Martin B. Dickman

    PNAS March 1, 2005 102 (9) 3459-3464; https://doi.org/10.1073/pnas.0407960102

    See companion article:

    • Balancing the generation and elimination of reactive oxygen species

      - Feb 22, 2005
    • This Week in PNAS

      - Mar 01, 2005
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    Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system

    Michelle Dziejman, Davide Serruto, Vincent C. Tam, Derek Sturtevant, Pornphan Diraphat, Shah M. Faruque, M. Hasibur Rahman, John F. Heidelberg, Jeremy Decker, Li Li, Kate T. Montgomery, George Grills, Raju Kucherlapati, and John J. Mekalanos

    PNAS March 1, 2005 102 (9) 3465-3470; https://doi.org/10.1073/pnas.0409918102
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    Demonstration of toxicity to fish and to mammalian cells by Pfiesteria species: Comparison of assay methods and strains

    JoAnn M. Burkholder, Andrew S. Gordon, Peter D. Moeller, J. Mac Law, Kathryn J. Coyne, Alan J. Lewitus, John S. Ramsdell, Harold G. Marshall, Nora J. Deamer, S. Craig Cary, Jason W. Kempton, Steven L. Morton, and Parke A. Rublee

    PNAS March 1, 2005 102 (9) 3471-3476; https://doi.org/10.1073/pnas.0500168102

• Neuroscience

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    A circuit for navigation in Caenorhabditis elegans

    • Inaugural Article

    Jesse M. Gray, Joseph J. Hill, and Cornelia I. Bargmann

    PNAS March 1, 2005 102 (9) 3184-3191; https://doi.org/10.1073/pnas.0409009101

    See companion article:

    • Biography of Cornelia I. Bargmann

      - Feb 22, 2005
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    Dissection of synaptic excitability phenotypes by using a dominant-negative Shaker K⁺ channel subunit

    Timothy J. Mosca, Robert A. Carrillo, Benjamin H. White, and Haig Keshishian

    PNAS March 1, 2005 102 (9) 3477-3482; https://doi.org/10.1073/pnas.0406164102
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    Uric acid protects against secondary damage after spinal cord injury

    Gwen S. Scott, Salvatore Cuzzocrea, Tiziana Genovese, Hilary Koprowski, and D. Craig Hooper

    PNAS March 1, 2005 102 (9) 3483-3488; https://doi.org/10.1073/pnas.0500307102
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    Phosphorylation of spinophilin by ERK and cyclin-dependent PK 5 (Cdk5)

    Marie Futter, Ken Uematsu, Stewart A. Bullock, Yong Kim, Hugh C. Hemmings Jr., Akinori Nishi, Paul Greengard, and Angus C. Nairn

    PNAS March 1, 2005 102 (9) 3489-3494; https://doi.org/10.1073/pnas.0409802102
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    Amphetamine induces dopamine efflux through a dopamine transporter channel

    Kristopher M. Kahlig, Francesca Binda, Habibeh Khoshbouei, Randy D. Blakely, Douglas G. McMahon, Jonathan A. Javitch, and Aurelio Galli

    PNAS March 1, 2005 102 (9) 3495-3500; https://doi.org/10.1073/pnas.0407737102
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    Diagnosis of human prion disease

    Jiri G. Safar, Michael D. Geschwind, Camille Deering, Svetlana Didorenko, Mamta Sattavat, Henry Sanchez, Ana Serban, Martin Vey, Henry Baron, Kurt Giles, Bruce L. Miller, Stephen J. DeArmond, and Stanley B. Prusiner

    PNAS March 1, 2005 102 (9) 3501-3506; https://doi.org/10.1073/pnas.0409651102
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    Single-neuron responses and neuronal decisions in a vernier task

    Ying Zhang and R. Clay Reid

    PNAS March 1, 2005 102 (9) 3507-3512; https://doi.org/10.1073/pnas.0409914102

    See companion article:

    • This Week in PNAS

      - Mar 01, 2005
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    Dopamine supersensitivity correlates with D2^High states, implying many paths to psychosis

    Philip Seeman, David Weinshenker, Remi Quirion, Lalit K. Srivastava, Sanjeev K. Bhardwaj, David K. Grandy, Richard T. Premont, Tatyana D. Sotnikova, Patricia Boksa, Mufida El-Ghundi, Brian F. O'Dowd, Susan R. George, Melissa L. Perreault, Pekka T. Männistö, Siobhan Robinson, Richard D. Palmiter, and Teresa Tallerico

    PNAS March 1, 2005 102 (9) 3513-3518; https://doi.org/10.1073/pnas.0409766102

• Psychology

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    Agrammatic but numerate

    • From the Cover

    Rosemary A. Varley, Nicolai J. C. Klessinger, Charles A. J. Romanowski, and Michael Siegal

    PNAS March 1, 2005 102 (9) 3519-3524; https://doi.org/10.1073/pnas.0407470102

    See companion article:

    • The independence of language and mathematical reasoning

      - Feb 22, 2005