High-amylose wheat generated by RNA interference improves indices of large-bowel health in rats

Ahmed Regina; Anthony Bird; David Topping; Sarah Bowden; Judy Freeman; Tina Barsby; Behjat Kosar-Hashemi; Zhongyi Li; Sadequr Rahman; Matthew Morell

doi:10.1073/pnas.0510737103

New Research In

Communicated by William James Peacock, Commonwealth Scientific and Industrial Research Organization, Canberra, Australia, December 14, 2005 (received for review October 4, 2005)

Online Impact

Article Information

vol. 103 no. 10 3546-3551

DOI:

https://doi.org/10.1073/pnas.0510737103

PubMed:

16537443

Published By:

National Academy of Sciences

Print ISSN:

0027-8424

Online ISSN:

1091-6490

History:

Published in issue March 7, 2006.
Published first February 28, 2006.

Author Information

Ahmed Regina * , ^† ,
Anthony Bird * , ^‡ ,
David Topping * , ^‡ ,
Sarah Bowden ^§ ,
Judy Freeman ^§ ,
Tina Barsby ^§ ,
Behjat Kosar-Hashemi * , ^† ,
Zhongyi Li * , ^† ,
Sadequr Rahman * , ^† , and
Matthew Morell * , ^† , ^¶

*Commonwealth Scientific and Industrial Research Organization, Food Futures National Research Flagship, P.O. Box 93, North Ryde 1670, NSW, Australia;
^†Commonwealth Scientific and Industrial Research Organization, Plant Industry, G.P.O. Box 1600, Canberra ACT 2601, Australia;
^‡Commonwealth Scientific and Industrial Research Organization, Human Nutrition, P.O. Box 10041, Adelaide BC 5000, SA, Australia; and
^§Biogemma UK Limited, 200 Science Park, Milton Road, Cambridge CB4 0GZ, United Kingdom

Communicated by William James Peacock, Commonwealth Scientific and Industrial Research Organization, Canberra, Australia, December 14, 2005 (received for review October 4, 2005)

Footnotes

^¶To whom correspondence should be addressed. E-mail: matthew.morell{at}csiro.au
Author contributions: A.R., A.B., D.T., J.F., T.B., Z.L., S.R., and M.M. designed research; A.R., A.B., S.B., and B.K.-H. performed research; A.R., A.B., D.T., S.B., J.F., T.B., B.K.-H., Z.L., S.R., and M.M. analyzed data; and A.R., A.B., D.T., J.F., B.K.-H., S.R., and M.M. wrote the paper.
Conflict of interest statement: No conflicts declared.
Abbreviations:
NSP,
nonstarch polysaccharides;
RS,
resistant starch;
SCFA,
short-chain fatty acid;
DP,
degree of polymerization;
SBE,
starch-branching enzyme;
RNAi,
RNA interference;
SEC,
size exclusion chromatography.

Cited By...

Article usage

Article usage: February 2006 to February 2021

	Abstract	Full	Pdf
Feb 2006	43	0	44
Mar 2006	877	190	543
Apr 2006	103	66	96
May 2006	56	76	85
Jun 2006	34	59	79
Jul 2006	25	44	43
Aug 2006	27	44	39
Sep 2006	44	62	55
Oct 2006	48	57	56
Nov 2006	58	121	94
Dec 2006	30	59	60
Total 2006	1345	778	1194
Jan 2007	41	95	64
Feb 2007	21	33	41
Mar 2007	30	72	57
Apr 2007	19	78	38
May 2007	27	63	52
Jun 2007	36	38	34
Jul 2007	9	22	24
Aug 2007	25	53	36
Sep 2007	25	56	46
Oct 2007	49	64	47
Nov 2007	40	68	36
Dec 2007	20	63	52
Total 2007	342	705	527
Jan 2008	28	52	56
Feb 2008	22	27	46
Mar 2008	22	48	36
Apr 2008	38	54	45
May 2008	23	28	29
Jun 2008	33	43	46
Jul 2008	78	30	19
Aug 2008	71	25	33
Sep 2008	118	26	45
Oct 2008	86	31	44
Nov 2008	105	60	51
Dec 2008	77	26	37
Total 2008	701	450	487
Jan 2009	117	53	59
Feb 2009	81	45	21
Mar 2009	98	45	54
Apr 2009	101	45	22
May 2009	79	35	35
Jun 2009	65	39	25
Jul 2009	89	42	29
Aug 2009	60	31	19
Sep 2009	54	35	34
Oct 2009	88	33	37
Nov 2009	79	42	40
Dec 2009	80	25	33
Total 2009	991	470	408
Jan 2010	72	35	39
Feb 2010	66	38	26
Mar 2010	73	38	30
Apr 2010	82	50	34
May 2010	55	53	24
Jun 2010	57	56	20
Jul 2010	52	33	18
Aug 2010	35	28	14
Sep 2010	49	52	18
Oct 2010	35	48	22
Nov 2010	62	37	21
Dec 2010	30	33	17
Total 2010	668	501	283
Jan 2011	53	56	31
Feb 2011	55	52	31
Mar 2011	58	63	29
Apr 2011	80	54	33
May 2011	67	32	35
Jun 2011	52	31	34
Jul 2011	136	51	23
Aug 2011	94	54	22
Sep 2011	99	54	19
Oct 2011	121	59	32
Nov 2011	112	54	38
Dec 2011	64	56	33
Total 2011	991	616	360
Jan 2012	88	37	31
Feb 2012	104	43	31
Mar 2012	117	64	31
Apr 2012	89	47	23
May 2012	111	45	39
Jun 2012	64	49	23
Jul 2012	64	44	15
Aug 2012	62	40	9
Sep 2012	92	53	27
Oct 2012	72	35	19
Nov 2012	74	45	33
Dec 2012	71	44	16
Total 2012	1008	546	297
Jan 2013	76	178	16
Feb 2013	126	41	20
Mar 2013	103	50	28
Apr 2013	117	49	18
May 2013	111	37	26
Jun 2013	65	29	23
Jul 2013	100	20	16
Aug 2013	57	27	14
Sep 2013	72	28	10
Oct 2013	96	45	13
Nov 2013	95	31	12
Dec 2013	77	25	21
Total 2013	1095	560	217
Jan 2014	64	29	7
Feb 2014	80	38	18
Mar 2014	86	44	22
Apr 2014	105	46	32
May 2014	91	29	19
Jun 2014	91	26	14
Jul 2014	129	28	23
Aug 2014	69	46	16
Sep 2014	239	36	16
Oct 2014	135	51	15
Nov 2014	79	25	15
Dec 2014	111	25	22
Total 2014	1279	423	219
Jan 2015	85	43	30
Feb 2015	74	23	13
Mar 2015	79	49	16
Apr 2015	55	24	10
May 2015	60	27	15
Jun 2015	52	24	7
Jul 2015	45	13	6
Aug 2015	31	20	15
Sep 2015	67	34	8
Oct 2015	69	26	27
Nov 2015	78	36	26
Dec 2015	87	37	25
Total 2015	782	356	198
Jan 2016	86	29	28
Feb 2016	87	38	31
Mar 2016	83	32	28
Apr 2016	62	19	19
May 2016	75	38	18
Jun 2016	54	22	25
Jul 2016	67	22	16
Aug 2016	53	25	24
Sep 2016	44	35	11
Oct 2016	57	26	15
Nov 2016	96	77	41
Dec 2016	67	39	24
Total 2016	831	402	280
Jan 2017	69	27	31
Feb 2017	68	12	41
Mar 2017	62	18	13
Apr 2017	65	22	14
May 2017	61	29	17
Jun 2017	42	20	14
Jul 2017	30	20	24
Aug 2017	34	22	16
Sep 2017	35	17	34
Oct 2017	37	38	31
Nov 2017	48	34	24
Dec 2017	158	24	22
Total 2017	709	283	281
Jan 2018	73	27	23
Feb 2018	32	39	13
Mar 2018	51	46	33
Apr 2018	55	51	29
May 2018	65	58	13
Jun 2018	31	42	10
Jul 2018	34	33	29
Aug 2018	42	33	13
Sep 2018	56	50	20
Oct 2018	11	36	11
Nov 2018	10	43	26
Dec 2018	2	35	13
Total 2018	462	493	233
Jan 2019	15	33	10
Feb 2019	4	44	10
Mar 2019	16	74	31
Apr 2019	12	61	37
May 2019	16	58	33
Jun 2019	4	52	15
Jul 2019	19	46	30
Aug 2019	6	30	17
Sep 2019	8	41	23
Oct 2019	23	60	22
Nov 2019	7	77	8
Dec 2019	6	45	6
Total 2019	136	621	242
Jan 2020	9	52	13
Feb 2020	13	62	18
Mar 2020	17	59	12
Apr 2020	8	45	9
May 2020	9	54	21
Jun 2020	7	52	15
Jul 2020	7	44	22
Aug 2020	0	36	8
Sep 2020	11	46	13
Oct 2020	17	70	19
Nov 2020	22	78	26
Dec 2020	27	51	28
Total 2020	147	649	204
Jan 2021	27	76	21
Feb 2021	8	32	9
Total 2021	35	108	30
Total	11522	7961	5460