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Table of Contents
August 01, 2006; vol. 103 no. 31
This Week in PNAS
- You have accessIn This Issue
See companion article:
- T lineage differentiation from human embryonic stem cells- Jul 14, 2006
- Targeting lentiviral vectors to specific cell types in vivo- Jul 24, 2006
Profile
- You have accessProfile of Lonnie G. ThompsonNick Zagorski
See companion article:
- Abrupt tropical climate change: Past and present- Jun 30, 2006
Physical Sciences
Applied Physical Sciences
- Open AccessMacromolecular-scale resolution in biological fluorescence microscopy
- Cozzarelli Prize Winner
Gerald Donnert, Jan Keller, Rebecca Medda, M. Alexandra Andrei, Silvio O. Rizzoli, Reinhard Lührmann, Reinhard Jahn, Christian Eggeling, and Stefan W. Hell
Chemistry
- Open AccessMolecular transport through channels and pores: Effects of in-channel interactions and blocking
- From the Cover
Wolfgang R. Bauer and Walter NadlerSee companion article:
- You have accessChemoresponsive monolayer transistorsXuefeng Guo, Matthew Myers, Shengxiong Xiao, Michael Lefenfeld, Rachel Steiner, George S. Tulevski, Jinyao Tang, Julian Baumert, Frank Leibfarth, James T. Yardley, Michael L. Steigerwald, Philip Kim, and Colin Nuckolls
- You have accessA mechanism to signal receptor–substrate interactions with luminescent quantum dotsIbrahim Yildiz, Massimiliano Tomasulo, and Françisco M. Raymo
- You have accessStructural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthasesFlorence Pojer, Jean-Luc Ferrer, Stéphane B. Richard, Dinesh A. Nagegowda, Mee-Len Chye, Thomas J. Bach, and Joseph P. Noel
Engineering
- You have accessVascularized organoid engineered by modular assembly enables blood perfusionAlison P. McGuigan and Michael V. Sefton
- You have accessScaling and saturation laws for the expansion of concrete exposed to sulfate attackPaulo J. M. Monteiro
Social Sciences
Psychology
- You have accessModulation of competing memory systems by distractionKarin Foerde, Barbara J. Knowlton, and Russell A. Poldrack
Biological Sciences
Applied Biological Sciences
- You have accessVascularized organoid engineered by modular assembly enables blood perfusionAlison P. McGuigan and Michael V. Sefton
- Open AccessQuantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical librariesJames Inglese, Douglas S. Auld, Ajit Jadhav, Ronald L. Johnson, Anton Simeonov, Adam Yasgar, Wei Zheng, and Christopher P. Austin
- Open AccessTargeting lentiviral vectors to specific cell types in vivoLili Yang, Leslie Bailey, David Baltimore, and Pin Wang
See companion article:
- In This Issue- Aug 01, 2006
Biochemistry
- Open AccessMPS1-dependent mitotic BLM phosphorylation is important for chromosome stabilityMei Leng, Doug W. Chan, Hao Luo, Cihui Zhu, Jun Qin, and Yi Wang
- You have accessStructural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthasesFlorence Pojer, Jean-Luc Ferrer, Stéphane B. Richard, Dinesh A. Nagegowda, Mee-Len Chye, Thomas J. Bach, and Joseph P. Noel
- You have accessDNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA·TTC repeats in Friedreich's ataxiaRyan Burnett, Christian Melander, James W. Puckett, Leslie S. Son, Robert D. Wells, Peter B. Dervan, and Joel M. Gottesfeld
- You have accessStructural basis for unique mechanisms of folding and hemoglobin binding by a malarial proteaseStephanie X. Wang, Kailash C. Pandey, John R. Somoza, Puran S. Sijwali, Tanja Kortemme, Linda S. Brinen, Robert J. Fletterick, Philip J. Rosenthal, and James H. McKerrow
- You have accessNanodiscs separate chemoreceptor oligomeric states and reveal their signaling propertiesThomas Boldog, Stephen Grimme, Mingshan Li, Stephen G. Sligar, and Gerald L. Hazelbauer
- You have accessRegulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrateGil Bornstein, Dvora Ganoth, and Avram Hershko
- You have accessCDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 proteinWon-Ho Cho, Young-Joo Lee, Soo-Im Kong, Jerard Hurwitz, and Joon-Kyu Lee
Biophysics
- Open AccessMacromolecular-scale resolution in biological fluorescence microscopy
- Cozzarelli Prize Winner
Gerald Donnert, Jan Keller, Rebecca Medda, M. Alexandra Andrei, Silvio O. Rizzoli, Reinhard Lührmann, Reinhard Jahn, Christian Eggeling, and Stefan W. Hell - Open AccessMolecular transport through channels and pores: Effects of in-channel interactions and blocking
- From the Cover
Wolfgang R. Bauer and Walter NadlerSee companion article:
- You have accessFree-energy distribution of binary protein–protein binding suggests cross-species interactome differencesYi Y. Shi, Gerald A. Miller, Hong Qian, and Karol Bomsztyk
- You have accessMolecular dynamics analyses of cross-β-spine steric zipper models: β-Sheet twisting and aggregationLuciana Esposito, Carlo Pedone, and Luigi Vitagliano
See companion article:
- In This Issue- Aug 01, 2006
- You have accessCoil–globule transition in the denatured state of a small proteinEilon Sherman and Gilad Haran
- You have accessDirect observation of DNA rotation during branch migration of Holliday junction DNA by Escherichia coli RuvA–RuvB protein complexYong-Woon Han, Tomomi Tani, Masahito Hayashi, Takashi Hishida, Hiroshi Iwasaki, Hideo Shinagawa, and Yoshie Harada
- You have accessCellular asymmetry and individuality in directional sensingAzadeh Samadani, Jerome Mettetal, and Alexander van Oudenaarden
- Open AccessTension-dependent DNA cleavage by restriction endonucleases: Two-site enzymes are “switched off” at low forceGregory J. Gemmen, Rachel Millin, and Douglas E. Smith
- You have accessSingle-molecule detection of structural changes during Per-Arnt-Sim (PAS) domain activationJason Ming Zhao, Haeshin Lee, Rene A. Nome, Sophia Majid, Norbert F. Scherer, and Wouter D. Hoff
Cell Biology
- Open AccessCyclin D1 repression of nuclear respiratory factor 1 integrates nuclear DNA synthesis and mitochondrial functionChenguang Wang, Zhiping Li, Yinan Lu, Runlei Du, Sanjay Katiyar, Jianguo Yang, Maofu Fu, Jennifer E. Leader, Andrew Quong, Phyllis M. Novikoff, and Richard G. Pestell
- Open AccessDifferent mitochondrial intermembrane space proteins are released during apoptosis in a manner that is coordinately initiated but can vary in durationCristina Muñoz-Pinedo, Ana Guío-Carrión, Joshua C. Goldstein, Patrick Fitzgerald, Donald D. Newmeyer, and Douglas R. Green
- Open AccessN-Myc and the cyclin-dependent kinase inhibitors p18Ink4c and p27Kip1 coordinately regulate cerebellar developmentFrederique Zindy, Paul S. Knoepfler, Suqing Xie, Charles J. Sherr, Robert N. Eisenman, and Martine F. Roussel
- You have accessA Drosophila model of Barth syndromeYang Xu, Morgan Condell, Heide Plesken, Irit Edelman-Novemsky, Jinping Ma, Mindong Ren, and Michael Schlame
- Open AccessE2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell systemDennis Flierman, Catherine S. Coleman, Cecile M. Pickart, Tom A. Rapoport, and Vincent Chau
Developmental Biology
- You have accessLiprin-α has LAR-independent functions in R7 photoreceptor axon targetingKerstin Hofmeyer, Corinne Maurel-Zaffran, Helen Sink, and Jessica E. Treisman
- You have accessLiprin-α is required for photoreceptor target selection in DrosophilaKwang-Min Choe, Saurabh Prakash, Ali Bright, and Thomas R. Clandinin
- You have accessAn early role for Sonic hedgehog from foregut endoderm in jaw development: Ensuring neural crest cell survivalJosé M. Brito, Marie-Aimée Teillet, and Nicole M. Le Douarin
- You have accessRobust, bistable patterning of the dorsal surface of the Drosophila embryoDavid M. Umulis, Mihaela Serpe, Michael B. O’Connor, and Hans G. Othmer
Evolution
- Open AccessSympatric speciation under incompatibility selectionYael Artzy-Randrup and Alexey S. Kondrashov
- Open AccessSolution structure of Urm1 and its implications for the origin of protein modifiersJunjie Xu, Jiahai Zhang, Li Wang, Jie Zhou, Hongda Huang, Jihui Wu, Yang Zhong, and Yunyu Shi
- You have accessThe role of the proline-rich domain of Ssdp1 in the modular architecture of the vertebrate head organizerBadam Enkhmandakh, Alexandr V. Makeyev, and Dashzeveg Bayarsaihan
- You have accessRepression and loss of gene expression outpaces activation and gain in recently duplicated fly genesTodd H. Oakley, Bjørn Østman, and Asa C. V. Wilson
Genetics
- You have accessCarcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instabilitySarah L. Donahue, Qing Lin, Shang Cao, and H. Earl Ruley
- You have accessGenome analysis of the smallest free-living eukaryote Ostreococcus tauri unveils many unique features
- From the Cover
Evelyne Derelle, Conchita Ferraz, Stephane Rombauts, Pierre Rouzé, Alexandra Z. Worden, Steven Robbens, Frédéric Partensky, Sven Degroeve, Sophie Echeynié, Richard Cooke, Yvan Saeys, Jan Wuyts, Kamel Jabbari, Chris Bowler, Olivier Panaud, Benoît Piégu, Steven G. Ball, Jean-Philippe Ral, François-Yves Bouget, Gwenael Piganeau, Bernard De Baets, André Picard, Michel Delseny, Jacques Demaille, Yves Van de Peer, and Hervé MoreauSee companion article:
- In This Issue- Aug 01, 2006
- Genome complexity in a lean, mean photosynthetic machine- Jul 25, 2006
- Open AccessThe regulatory utilization of genetic redundancy through responsive backup circuitsRan Kafri, Melissa Levy, and Yitzhak Pilpel
- Open AccessA family of conserved noncoding elements derived from an ancient transposable elementXiaohui Xie, Michael Kamal, and Eric S. Lander
Immunology
- Open AccessThe Ets factor Spi-B is a direct critical target of the coactivator OBF-1Boris Bartholdy, Camille Du Roure, Alain Bordon, Dianne Emslie, Lynn M. Corcoran, and Patrick Matthias
- You have accessDirect stimulation of T cells by membrane vesicles from antigen-presenting cellsMarek Kovar, Onur Boyman, Xuefei Shen, Inkyu Hwang, Rachel Kohler, and Jonathan Sprent
- You have accessEssential role of TAK1 in thymocyte development and activationHong-Hsing Liu, Min Xie, Michael D. Schneider, and Zhijian J. Chen
- You have accessDRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotypeIvana Durinovic-Belló, Silke Rosinger, Jennifer A. Olson, Mauro Congia, Regina C. Ahmad, Mathias Rickert, Johannes Hampl, Hubert Kalbacher, Jan W. Drijfhout, Elizabeth D. Mellins, Sascha Al Dahouk, Thomas Kamradt, Markus J. Maeurer, Carol Nhan, Bart O. Roep, Bernhard O. Boehm, Constantin Polychronakos, Gerald T. Nepom, Wolfram Karges, Hugh O. McDevitt, and Grete Sønderstrup
- You have accessNitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cellsMarcella Ferlito, Kaikobad Irani, Nauder Faraday, and Charles J. Lowenstein
- You have accessRegulation of T cell activation and tolerance by PDL2Yongliang Zhang, Yeonseok Chung, Caroline Bishop, Betsy Daugherty, Hilary Chute, Paige Holst, Carole Kurahara, Fred Lott, Ning Sun, Andrew A. Welcher, and Chen Dong
Medical Sciences
- You have accessDifferential HIV-1 replication in neonatal and adult blood mononuclear cells is influenced at the level of HIV-1 gene expressionVasudha Sundaravaradan, Shailendra K. Saxena, Rajesh Ramakrishnan, Venkat R. K. Yedavalli, David T. Harris, and Nafees Ahmad
- You have accessInhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cellsJohn P. Chute, Garrett G. Muramoto, John Whitesides, Michael Colvin, Rachid Safi, Nelson J. Chao, and Donald P. McDonnell
- Open AccessB cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemiaXiao-jie Yan, Emilia Albesiano, Nicola Zanesi, Sophia Yancopoulos, Alan Sawyer, Egidio Romano, Aleksandar Petlickovski, Dimitar G. Efremov, Carlo M. Croce, and Nicholas Chiorazzi
- You have accessNoninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruptionManabu Kinoshita, Nathan McDannold, Ferenc A. Jolesz, and Kullervo Hynynen
- You have accessIdentification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cellsXueni Chen, Brian A. Hyatt, Michael L. Mucenski, Robert J. Mason, and John M. Shannon
- Open AccessUnique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapyYan Shou, Zhijun Ma, Taihe Lu, and Brian P. Sorrentino
- You have accessTopical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitisMei Li, Pierre Hener, Zhikun Zhang, Shigeaki Kato, Daniel Metzger, and Pierre Chambon
- You have accessT lineage differentiation from human embryonic stem cells
- From the Cover
Zoran Galić, Scott G. Kitchen, Amelia Kacena, Aparna Subramanian, Bryan Burke, Ruth Cortado, and Jerome A. ZackSee companion article:
- In This Issue- Aug 01, 2006
- Embryonic stem cells make human T cells- Aug 07, 2006
- You have accessReversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophyRahul N. Kanadia, Jihae Shin, Yuan Yuan, Stuart G. Beattie, Thurman M. Wheeler, Charles A. Thornton, and Maurice S. Swanson
Microbiology
- You have accessIdentification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coliTao Wu, Andrew C. McCandlish, Luisa S. Gronenberg, Shu-Sin Chng, Thomas J. Silhavy, and Daniel Kahne
- You have accessCharacterization of mycobacterial virulence genes through genetic interaction mappingSwati M. Joshi, Amit K. Pandey, Nicole Capite, Sarah M. Fortune, Eric J. Rubin, and Christopher M. Sassetti
- Open AccessAdaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plagueFlorent Sebbane, Nadine Lemaître, Daniel E. Sturdevant, Roberto Rebeil, Kimmo Virtaneva, Stephen F. Porcella, and B. Joseph Hinnebusch
- You have accessA nutrient uptake role for bacterial cell envelope extensions
- From the Cover
Jennifer K. Wagner, Sima Setayeshgar, Laura A. Sharon, James P. Reilly, and Yves V. BrunSee companion article:
- In This Issue- Aug 01, 2006
- Bacterial stalks are nutrient-scavenging antennas- Jul 25, 2006
Neuroscience
- You have accessModulation of competing memory systems by distractionKarin Foerde, Barbara J. Knowlton, and Russell A. Poldrack
- You have accessGlatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
- From the Cover
Oleg Butovsky, Maya Koronyo-Hamaoui, Gilad Kunis, Eran Ophir, Gennady Landa, Hagit Cohen, and Michal Schwartz - Open AccessMicrosomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injuryYuri Ikeda-Matsuo, Azusa Ota, Tetsuya Fukada, Satoshi Uematsu, Shizuo Akira, and Yasuharu Sasaki
Plant Biology
- You have accessRole of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylationFernanda Agius, Avnish Kapoor, and Jian-Kang Zhu
Population Biology
- You have accessEcological and immunological determinants of dengue epidemicsHelen J. Wearing and Pejman Rohani
Psychology
- You have accessSpatial remapping of touch: Confusion of perceived stimulus order across hand and footTobias Schicke and Brigitte Röder
Commentaries
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