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Research Article

Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins

Natalia Slepko, Anusri M. Bhattacharyya, George R. Jackson, Joan S. Steffan, J. Lawrence Marsh, Leslie Michels Thompson, and Ronald Wetzel
PNAS September 26, 2006 103 (39) 14367-14372; https://doi.org/10.1073/pnas.0602348103
Natalia Slepko
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Anusri M. Bhattacharyya
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George R. Jackson
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Joan S. Steffan
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J. Lawrence Marsh
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Leslie Michels Thompson
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Ronald Wetzel
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  • For correspondence: rwetzel@pitt.edu
  1. Edited by Sue Hengren Wickner, National Institutes of Health, Bethesda, MD, and approved August 1, 2006 (received for review March 22, 2006)

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Article Information

vol. 103 no. 39 14367-14372
DOI: 
https://doi.org/10.1073/pnas.0602348103
PubMed: 
16980414

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue September 26, 2006.
  • Published first September 15, 2006.

Copyright & Usage: 
© 2006 by The National Academy of Sciences of the USA

Author Information

  1. Natalia Slepko † ,
  2. Anusri M. Bhattacharyya ‡ ,
  3. George R. Jackson § ,
  4. Joan S. Steffan † ,
  5. J. Lawrence Marsh ¶ ,
  6. Leslie Michels Thompson † , ‖ , and
  7. Ronald Wetzel ‡ , ††
  1. Departments of †Psychiatry and Human Behavior and
  2. ‖Biological Chemistry, University of California, Irvine, CA 92697-4260;
  3. ‡Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920;
  4. §Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and
  5. ¶Developmental Biology Center and Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300
  1. Edited by Sue Hengren Wickner, National Institutes of Health, Bethesda, MD, and approved August 1, 2006 (received for review March 22, 2006)

Footnotes

  • ††To whom correspondence should be sent at the present address:
    Department of Structural Biology, University of Pittsburgh School of Medicine, 2044 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260.
    E-mail: rwetzel{at}pitt.edu
  • Author contributions: N.S. and A.M.B. contributed equally to this work; N.S., A.M.B., G.R.J., J.S.S., J.L.M., L.M.T., and R.W. designed research; N.S. and A.M.B. performed research; G.R.J. contributed new reagents/analytic tools; N.S., A.M.B., G.R.J., J.S.S., J.L.M., L.M.T., and R.W. analyzed data; and N.S., A.M.B., G.R.J., J.S.S., J.L.M., L.M.T., and R.W. wrote the paper.

  • The authors declare no conflict of interest.

  • This paper was submitted directly (Track II) to the PNAS office.

  • © 2006 by The National Academy of Sciences of the USA

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Article usage: September 2006 to January 2021

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Sep 200631335339
Oct 2006119157178
Nov 2006446675
Dec 2006183448
Total 2006494292640
Jan 2007184331
Feb 2007111828
Mar 2007103735
Apr 200792721
May 2007123731
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Jul 2007101612
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Sep 200762014
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Total 2007114288249
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Feb 2008102216
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Apr 200872430
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Jul 2008381011
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Total 2008277202195
Jan 200917210
Feb 20092355
Mar 2009171822
Apr 200915167
May 2009142116
Jun 2009162012
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Aug 200917119
Sep 2009943
Oct 2009231117
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Dec 200913166
Total 2009202171139
Jan 2010211618
Feb 20101163
Mar 2010281211
Apr 201010104
May 20108105
Jun 201012114
Jul 20108126
Aug 201017117
Sep 20106117
Oct 20108115
Nov 201014102
Dec 2010131814
Total 201015613886
Jan 201111177
Feb 201113136
Mar 20119129
Apr 20115117
May 2011112512
Jun 2011684
Jul 20118108
Aug 20118165
Sep 2011887
Oct 201116147
Nov 201120138
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Total 201112915293
Jan 2012121413
Feb 2012833
Mar 20121294
Apr 20121256
May 201211118
Jun 2012887
Jul 2012566
Aug 2012672
Sep 2012674
Oct 20123126
Nov 2012677
Dec 2012468
Total 2012939574
Jan 20132094
Feb 2013531
Mar 20131234
Apr 20131447
May 201325105
Jun 2013974
Jul 20138128
Aug 20131393
Sep 20131339
Oct 2013973
Nov 201316125
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Total 20131518654
Jan 20141171
Feb 20141294
Mar 20141194
Apr 20141197
May 2014893
Jun 2014723
Jul 20148167
Aug 201419211
Sep 20147176
Oct 2014131412
Nov 2014466
Dec 20149423
Total 201412016157
Jan 201511183
Feb 201510157
Mar 2015962
Apr 201516135
May 20151067
Jun 2015778
Jul 20151114
Aug 201516125
Sep 20151127
Oct 20151346
Nov 2015844
Dec 2015844
Total 201512010262
Jan 2016191215
Feb 2016937
Mar 2016866
Apr 2016233
May 2016175
Jun 2016574
Jul 20168712
Aug 2016642
Sep 20161011
Oct 2016934
Nov 20161144
Dec 20161458
Total 20161026271
Jan 2017943
Feb 2017990
Mar 2017631
Apr 2017313
May 20171142
Jun 20171346
Jul 20177264
Aug 20171973
Sep 2017472
Oct 2017173
Nov 2017732
Dec 2017612
Total 2017957631
Jan 20185112
Feb 201819197
Mar 20188116
Apr 2018594
May 20188104
Jun 2018363
Jul 20186102
Aug 20189122
Sep 20189101
Oct 201811310
Nov 2018091
Dec 20180112
Total 20187313144
Jan 20191102
Feb 2019090
Mar 20190107
Apr 20191118
May 20191166
Jun 2019084
Jul 20192811
Aug 20192139
Sep 2019084
Oct 2019152
Nov 2019475
Dec 20192184
Total 20191412362
Jan 2020182
Feb 20202125
Mar 20200127
Apr 20200178
May 20203116
Jun 2020285
Jul 20202144
Aug 2020193
Sep 2020141
Oct 2020145
Nov 20207115
Dec 202061712
Total 20202612763
Jan 20212112
Total 20212112
Total216822171922
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Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins
Natalia Slepko, Anusri M. Bhattacharyya, George R. Jackson, Joan S. Steffan, J. Lawrence Marsh, Leslie Michels Thompson, Ronald Wetzel
Proceedings of the National Academy of Sciences Sep 2006, 103 (39) 14367-14372; DOI: 10.1073/pnas.0602348103

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Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins
Natalia Slepko, Anusri M. Bhattacharyya, George R. Jackson, Joan S. Steffan, J. Lawrence Marsh, Leslie Michels Thompson, Ronald Wetzel
Proceedings of the National Academy of Sciences Sep 2006, 103 (39) 14367-14372; DOI: 10.1073/pnas.0602348103
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