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Normal-repeat-length polyglutamine peptides accelerate aggregation nucleation and cytotoxicity of expanded polyglutamine proteins
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Edited by Sue Hengren Wickner, National Institutes of Health, Bethesda, MD, and approved August 1, 2006 (received for review March 22, 2006)

Online Impact
Article Information
- Published in issue September 26, 2006.
- Published first September 15, 2006.
Author Information
- Natalia Slepko † ,
- Anusri M. Bhattacharyya ‡ ,
- George R. Jackson § ,
- Joan S. Steffan † ,
- J. Lawrence Marsh ¶ ,
- Leslie Michels Thompson † , ‖ , and
- Ronald Wetzel ‡ , ††
- Departments of †Psychiatry and Human Behavior and
- ‖Biological Chemistry, University of California, Irvine, CA 92697-4260;
- ‡Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920;
- §Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095; and
- ¶Developmental Biology Center and Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300
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Edited by Sue Hengren Wickner, National Institutes of Health, Bethesda, MD, and approved August 1, 2006 (received for review March 22, 2006)
Footnotes
- ††To whom correspondence should be sent at the present address: Department of Structural Biology, University of Pittsburgh School of Medicine, 2044 Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260. E-mail: rwetzel{at}pitt.edu
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Author contributions: N.S. and A.M.B. contributed equally to this work; N.S., A.M.B., G.R.J., J.S.S., J.L.M., L.M.T., and R.W. designed research; N.S. and A.M.B. performed research; G.R.J. contributed new reagents/analytic tools; N.S., A.M.B., G.R.J., J.S.S., J.L.M., L.M.T., and R.W. analyzed data; and N.S., A.M.B., G.R.J., J.S.S., J.L.M., L.M.T., and R.W. wrote the paper.
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The authors declare no conflict of interest.
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This paper was submitted directly (Track II) to the PNAS office.
- © 2006 by The National Academy of Sciences of the USA
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