Table of Contents

Biological Sciences

• Biochemistry

  • Open Access

    Abscisic acid is an endogenous cytokine in human granulocytes with cyclic ADP-ribose as second messenger

    Santina Bruzzone, Iliana Moreschi, Cesare Usai, Lucrezia Guida, Gianluca Damonte, Annalisa Salis, Sonia Scarfì, Enrico Millo, Antonio De Flora, and Elena Zocchi

    PNAS April 3, 2007 104 (14) 5759-5764; https://doi.org/10.1073/pnas.0609379104
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    The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation

    Oyetunji A. Toogun, Will Zeiger, and Brian C. Freeman

    PNAS April 3, 2007 104 (14) 5765-5770; https://doi.org/10.1073/pnas.0701442104
  • Open Access

    Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway

    Ami S. Bhatt, Alana Welm, Christopher J. Farady, Maximiliano Vásquez, Keith Wilson, and Charles S. Craik

    PNAS April 3, 2007 104 (14) 5771-5776; https://doi.org/10.1073/pnas.0606514104
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    Structural basis for the selection of glycosylated substrates by SCF^Fbs1 ubiquitin ligase

    Tsunehiro Mizushima, Yukiko Yoshida, Taichi Kumanomidou, Yuko Hasegawa, Atsuo Suzuki, Takashi Yamane, and Keiji Tanaka

    PNAS April 3, 2007 104 (14) 5777-5781; https://doi.org/10.1073/pnas.0610312104
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    Structural insight into substrate specificity of phosphodiesterase 10

    • From the Cover

    Huanchen Wang, Yudong Liu, Jing Hou, Meiyan Zheng, Howard Robinson, and Hengming Ke

    PNAS April 3, 2007 104 (14) 5782-5787; https://doi.org/10.1073/pnas.0700279104
  • Open Access

    Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex

    Robert J. C. Gilbert, Yulya Gordiyenko, Tobias von der Haar, Andreas F.-P. Sonnen, Gregor Hofmann, Maria Nardelli, David I. Stuart, and John E. G. McCarthy

    PNAS April 3, 2007 104 (14) 5788-5793; https://doi.org/10.1073/pnas.0606880104
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    Estrogen receptor α is a putative substrate for the BRCA1 ubiquitin ligase

    Catherine M. Eakin, Michael J. MacCoss, Gregory L. Finney, and Rachel E. Klevit

    PNAS April 3, 2007 104 (14) 5794-5799; https://doi.org/10.1073/pnas.0610887104
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    Interdomain communication in calcium pump as revealed in the crystal structures with transmembrane inhibitors

    Mihoko Takahashi, Youhei Kondou, and Chikashi Toyoshima

    PNAS April 3, 2007 104 (14) 5800-5805; https://doi.org/10.1073/pnas.0700979104
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    Extrachromosomal element capture and the evolution of multiple replication origins in archaeal chromosomes

    Nicholas P. Robinson and Stephen D. Bell

    PNAS April 3, 2007 104 (14) 5806-5811; https://doi.org/10.1073/pnas.0700206104
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    Chemical inhibition of the TFIIH-associated kinase Cdk7/Kin28 does not impair global mRNA synthesis

    Elenita I. Kanin, Ryan T. Kipp, Charles Kung, Matthew Slattery, Agnes Viale, Steven Hahn, Kevan M. Shokat, and Aseem Z. Ansari

    PNAS April 3, 2007 104 (14) 5812-5817; https://doi.org/10.1073/pnas.0611505104
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    Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme

    M. Duane Smith and Richard A. Collins

    PNAS April 3, 2007 104 (14) 5818-5823; https://doi.org/10.1073/pnas.0608864104

• Biophysics

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    Destruction of long-range interactions by a single mutation in lysozyme

    Ruhong Zhou, Maria Eleftheriou, Ajay K. Royyuru, and Bruce J. Berne

    PNAS April 3, 2007 104 (14) 5824-5829; https://doi.org/10.1073/pnas.0701249104
  • Open Access

    Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting

    Thomas M. Hansen, S. Nader S. Reihani, Lene B. Oddershede, and Michael A. Sørensen

    PNAS April 3, 2007 104 (14) 5830-5835; https://doi.org/10.1073/pnas.0608668104

• Cell Biology

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    CCR4/NOT complex associates with the proteasome and regulates histone methylation

    R. Nicholas Laribee, Yoichiro Shibata, Douglas P. Mersman, Sean R. Collins, Patrick Kemmeren, Assen Roguev, Jonathan S. Weissman, Scott D. Briggs, Nevan J. Krogan, and Brian D. Strahl

    PNAS April 3, 2007 104 (14) 5836-5841; https://doi.org/10.1073/pnas.0607996104
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    Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons

    Xiang Zhou, J. Ramesh Babu, Susana da Silva, Qing Shu, Isabella A. Graef, Tim Oliver, Toshifumi Tomoda, Tomomi Tani, Marie W. Wooten, and Fan Wang

    PNAS April 3, 2007 104 (14) 5842-5847; https://doi.org/10.1073/pnas.0701402104
  • Open Access

    Hepatitis C virus production by human hepatocytes dependent on assembly and secretion of very low-density lipoproteins

    • From the Cover

    Hua Huang, Fang Sun, David M. Owen, Weiping Li, Yan Chen, Michael Gale Jr., and Jin Ye

    PNAS April 3, 2007 104 (14) 5848-5853; https://doi.org/10.1073/pnas.0700760104

    See companion article:

    • In This Issue

      - Apr 03, 2007
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    Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement

    Seth DeBolt, Ryan Gutierrez, David W. Ehrhardt, Carlos V. Melo, Loretta Ross, Sean R. Cutler, Christopher Somerville, and Dario Bonetta

    PNAS April 3, 2007 104 (14) 5854-5859; https://doi.org/10.1073/pnas.0700789104
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    Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks

    Alejandro Wolf-Yadlin, Sampsa Hautaniemi, Douglas A. Lauffenburger, and Forest M. White

    PNAS April 3, 2007 104 (14) 5860-5865; https://doi.org/10.1073/pnas.0608638104
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    Signaling-dependent and coordinated regulation of transcription, splicing, and translation resides in a single coregulator, PCBP1

    Qingchang Meng, Suresh K. Rayala, Anupama E. Gururaj, Amjad H. Talukder, Bert W. O'Malley, and Rakesh Kumar

    PNAS April 3, 2007 104 (14) 5866-5871; https://doi.org/10.1073/pnas.0701065104
  • Open Access

    Rab27b regulates number and secretion of platelet dense granules

    Tanya Tolmachova, Magnus Åbrink, Clare E. Futter, Kalwant S. Authi, and Miguel C. Seabra

    PNAS April 3, 2007 104 (14) 5872-5877; https://doi.org/10.1073/pnas.0609879104
  • Open Access

    Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties

    Michelle B. Bowie, David G. Kent, Brad Dykstra, Kristen D. McKnight, Lindsay McCaffrey, Pamela A. Hoodless, and Connie J. Eaves

    PNAS April 3, 2007 104 (14) 5878-5882; https://doi.org/10.1073/pnas.0700460104
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    Molecular and electrophysiological characterization of a mechanosensitive channel expressed in the chloroplasts of Chlamydomonas

    Yoshitaka Nakayama, Kenta Fujiu, Masahiro Sokabe, and Kenjiro Yoshimura

    PNAS April 3, 2007 104 (14) 5883-5888; https://doi.org/10.1073/pnas.0609996104
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    Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy

    Prashant Prabhat, Zhuo Gan, Jerry Chao, Sripad Ram, Carlos Vaccaro, Steven Gibbons, Raimund J. Ober, and E. Sally Ward

    PNAS April 3, 2007 104 (14) 5889-5894; https://doi.org/10.1073/pnas.0700337104

• Developmental Biology

  • Open Access

    Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

    Barbara Stecca, Christophe Mas, Virginie Clement, Marie Zbinden, Rafael Correa, Vincent Piguet, Friedrich Beermann, and Ariel Ruiz i Altaba

    PNAS April 3, 2007 104 (14) 5895-5900; https://doi.org/10.1073/pnas.0700776104
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    nanos function is essential for development and regeneration of planarian germ cells

    Yuying Wang, Ricardo M. Zayas, Tingxia Guo, and Phillip A. Newmark

    PNAS April 3, 2007 104 (14) 5901-5906; https://doi.org/10.1073/pnas.0609708104
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    Cranial muscle defects of Pitx2 mutants result from specification defects in the first branchial arch

    Hung Ping Shih, Michael K. Gross, and Chrissa Kioussi

    PNAS April 3, 2007 104 (14) 5907-5912; https://doi.org/10.1073/pnas.0701122104
  • Open Access

    Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord

    Sang-Yeob Yeo and Ajay B. Chitnis

    PNAS April 3, 2007 104 (14) 5913-5918; https://doi.org/10.1073/pnas.0607062104
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    Crucial roles of Foxa2 in mouse anterior–posterior axis polarization via regulation of anterior visceral endoderm-specific genes

    Chiharu Kimura-Yoshida, E. Tian, Hiroshi Nakano, Saori Amazaki, Kayo Shimokawa, Janet Rossant, Shinichi Aizawa, and Isao Matsuo

    PNAS April 3, 2007 104 (14) 5919-5924; https://doi.org/10.1073/pnas.0607779104

• Ecology

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    Homogenization of regional river dynamics by dams and global biodiversity implications

    • From the Cover

    N. LeRoy Poff, Julian D. Olden, David M. Merritt, and David M. Pepin

    PNAS April 3, 2007 104 (14) 5732-5737; https://doi.org/10.1073/pnas.0609812104

    See companion article:

    • In This Issue

      - Apr 03, 2007
    • Homogenous rivers, homogenous faunas

      - Apr 03, 2007
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    Projected distributions of novel and disappearing climates by 2100 AD

    John W. Williams, Stephen T. Jackson, and John E. Kutzbach

    PNAS April 3, 2007 104 (14) 5738-5742; https://doi.org/10.1073/pnas.0606292104

    See companion article:

    • In This Issue

      - Apr 03, 2007
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    Global patterns and determinants of vascular plant diversity

    Holger Kreft and Walter Jetz

    PNAS April 3, 2007 104 (14) 5925-5930; https://doi.org/10.1073/pnas.0608361104
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    Coarse-grained analysis of stochasticity-induced switching between collective motion states

    Allison Kolpas, Jeff Moehlis, and Ioannis G. Kevrekidis

    PNAS April 3, 2007 104 (14) 5931-5935; https://doi.org/10.1073/pnas.0608270104

• Evolution

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    High-resolution species trees without concatenation

    Scott V. Edwards, Liang Liu, and Dennis K. Pearl

    PNAS April 3, 2007 104 (14) 5936-5941; https://doi.org/10.1073/pnas.0607004104
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    Transgenerational epigenetic imprints on mate preference

    David Crews, Andrea C. Gore, Timothy S. Hsu, Nygerma L. Dangleben, Michael Spinetta, Timothy Schallert, Matthew D. Anway, and Michael K. Skinner

    PNAS April 3, 2007 104 (14) 5942-5946; https://doi.org/10.1073/pnas.0610410104

• Genetics

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    Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex

    Arjumand Ghazi, Sivan Henis-Korenblit, and Cynthia Kenyon

    PNAS April 3, 2007 104 (14) 5947-5952; https://doi.org/10.1073/pnas.0700638104
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    Riboflavin activated by ultraviolet A1 irradiation induces oxidative DNA damage-mediated mutations inhibited by vitamin C

    Ahmad Besaratinia, Sang-in Kim, Steven E. Bates, and Gerd P. Pfeifer

    PNAS April 3, 2007 104 (14) 5953-5958; https://doi.org/10.1073/pnas.0610534104
  • Open Access

    Metagene projection for cross-platform, cross-species characterization of global transcriptional states

    Pablo Tamayo, Daniel Scanfeld, Benjamin L. Ebert, Michael A. Gillette, Charles W. M. Roberts, and Jill P. Mesirov

    PNAS April 3, 2007 104 (14) 5959-5964; https://doi.org/10.1073/pnas.0701068104
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    Meiotic recombination-related DNA synthesis and its implications for cross-over and non-cross-over recombinant formation

    Masahiro Terasawa, Hideyuki Ogawa, Yasumasa Tsukamoto, Miki Shinohara, Katsuhiko Shirahige, Nancy Kleckner, and Tomoko Ogawa

    PNAS April 3, 2007 104 (14) 5965-5970; https://doi.org/10.1073/pnas.0611490104

• Immunology

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    Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals

    • From the Cover

    Anneliese O. Speak, Mariolina Salio, David C. A. Neville, Josette Fontaine, David A. Priestman, Nick Platt, Tanya Heare, Terry D. Butters, Raymond A. Dwek, Francois Trottein, Mark A. Exley, Vincenzo Cerundolo, and Frances M. Platt

    PNAS April 3, 2007 104 (14) 5971-5976; https://doi.org/10.1073/pnas.0607285104

    See companion article:

    • In This Issue

      - Apr 03, 2007
    • Natural killer T cells: Know thyself

      - Apr 03, 2007
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    Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency

    • From the Cover

    Stefan Porubsky, Anneliese O. Speak, Bruno Luckow, Vincenzo Cerundolo, Frances M. Platt, and Hermann-Josef Gröne

    PNAS April 3, 2007 104 (14) 5977-5982; https://doi.org/10.1073/pnas.0611139104

    See companion article:

    • Natural killer T cells: Know thyself

      - Apr 03, 2007
    • In This Issue

      - Apr 03, 2007
  • You have access

    Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing

    Yusuke Mimura, Yuka Mimura-Kimura, Katie Doores, Denise Golgher, Benjamin G. Davis, Raymond A. Dwek, Pauline M. Rudd, and Tim Elliott

    PNAS April 3, 2007 104 (14) 5983-5988; https://doi.org/10.1073/pnas.0701307104
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    Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules

    Anna M. Keller, Tom A. Groothuis, Elise A. M. Veraar, Marije Marsman, Lucas Maillette de Buy Wenniger, Hans Janssen, Jacques Neefjes, and Jannie Borst

    PNAS April 3, 2007 104 (14) 5989-5994; https://doi.org/10.1073/pnas.0700946104

• Medical Sciences

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    Exercise reverses preamyloid oligomer and prolongs survival in αB-crystallin-based desmin-related cardiomyopathy

    Alina Maloyan, James Gulick, Charles G. Glabe, Rakez Kayed, and Jeffrey Robbins

    PNAS April 3, 2007 104 (14) 5995-6000; https://doi.org/10.1073/pnas.0609202104

    See companion article:

    • In This Issue

      - Apr 03, 2007
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    Ott1(Rbm15) has pleiotropic roles in hematopoietic development

    Glen D. Raffel, Thomas Mercher, Hirokazu Shigematsu, Ifor R. Williams, Dana E. Cullen, Koichi Akashi, Olivier A. Bernard, and D. Gary Gilliland

    PNAS April 3, 2007 104 (14) 6001-6006; https://doi.org/10.1073/pnas.0609041104
  • Open Access

    Correction of prototypic ATM splicing mutations and aberrant ATM function with antisense morpholino oligonucleotides

    Liutao Du, Julianne M. Pollard, and Richard A. Gatti

    PNAS April 3, 2007 104 (14) 6007-6012; https://doi.org/10.1073/pnas.0608616104
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    Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions

    Shotaro Suzuki, Candice M. Brown, Christopher D. Dela Cruz, Enhua Yang, David A. Bridwell, and Phyllis M. Wise

    PNAS April 3, 2007 104 (14) 6013-6018; https://doi.org/10.1073/pnas.0610394104
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    Toll-like receptor-MyD88 and Fc receptor pathways of mast cells mediate the thyroid dysfunctions observed during nonthyroidal illness

    Roberto Rocchi, Hiroaki Kimura, Shey-Cherng Tzou, Koichi Suzuki, Noel R. Rose, Aldo Pinchera, Paul W. Ladenson, and Patrizio Caturegli

    PNAS April 3, 2007 104 (14) 6019-6024; https://doi.org/10.1073/pnas.0701319104
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    Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C

    Jan M. Pestka, Mirjam B. Zeisel, Edith Bläser, Peter Schürmann, Birke Bartosch, Francois-Loïc Cosset, Arvind H. Patel, Helga Meisel, Jens Baumert, Sergei Viazov, Kay Rispeter, Hubert E. Blum, Michael Roggendorf, and Thomas F. Baumert

    PNAS April 3, 2007 104 (14) 6025-6030; https://doi.org/10.1073/pnas.0607026104

• Microbiology

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    Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

    Sylvie Alonso, Kevin Pethe, David G. Russell, and Georgiana E. Purdy

    PNAS April 3, 2007 104 (14) 6031-6036; https://doi.org/10.1073/pnas.0700036104
  • Open Access

    In vivo negative selection screen identifies genes required for Francisella virulence

    David S. Weiss, Anna Brotcke, Thomas Henry, Jeffrey J. Margolis, Kaman Chan, and Denise M. Monack

    PNAS April 3, 2007 104 (14) 6037-6042; https://doi.org/10.1073/pnas.0609675104
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    Combinatorial transcriptional control of the lactose operon of Escherichia coli

    Thomas Kuhlman, Zhongge Zhang, Milton H. Saier Jr., and Terence Hwa

    PNAS April 3, 2007 104 (14) 6043-6048; https://doi.org/10.1073/pnas.0606717104
  • Open Access

    Viral activation and recruitment of metacaspases in the unicellular coccolithophore, Emiliania huxleyi

    Kay D. Bidle, Liti Haramaty, Joana Barcelos e Ramos, and Paul Falkowski

    PNAS April 3, 2007 104 (14) 6049-6054; https://doi.org/10.1073/pnas.0701240104

• Neuroscience

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    Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors

    Paul J. Kammermeier and Paul F. Worley

    PNAS April 3, 2007 104 (14) 6055-6060; https://doi.org/10.1073/pnas.0608991104
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    Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia

    Mary M. Lunzer, Ajay Yekkirala, Robert P. Hebbel, and Philip S. Portoghese

    PNAS April 3, 2007 104 (14) 6061-6065; https://doi.org/10.1073/pnas.0700295104
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    Neural encoding of the concept of nest in the mouse brain

    Longnian Lin, Guifen Chen, Hui Kuang, Dong Wang, and Joe Z. Tsien

    PNAS April 3, 2007 104 (14) 6066-6071; https://doi.org/10.1073/pnas.0701106104
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    Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology

    Marjatta Son, Krishna Puttaparthi, Hibiki Kawamata, Bhagya Rajendran, Philip J. Boyer, Giovanni Manfredi, and Jeffrey L. Elliott

    PNAS April 3, 2007 104 (14) 6072-6077; https://doi.org/10.1073/pnas.0610923104
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    Cytosolic phospholipase A₂ alpha mediates electrophysiologic responses of hippocampal pyramidal neurons to neurotoxic NMDA treatment

    Ying Shen, Koji Kishimoto, David J. Linden, and Adam Sapirstein

    PNAS April 3, 2007 104 (14) 6078-6083; https://doi.org/10.1073/pnas.0605427104

• Pharmacology

  • Open Access

    Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA

    • Inaugural Article

    Jeremy D. Heidel, Zhongping Yu, Joanna Yi-Ching Liu, Shyam M. Rele, Yongchao Liang, Ryan K. Zeidan, Douglas J. Kornbrust, and Mark E. Davis

    PNAS April 3, 2007 104 (14) 5715-5721; https://doi.org/10.1073/pnas.0701458104

• Psychology

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    Genomic imprinting mediates sexual experience-dependent olfactory learning in male mice

    William T. Swaney, James P. Curley, Frances A. Champagne, and Eric B. Keverne

    PNAS April 3, 2007 104 (14) 6084-6089; https://doi.org/10.1073/pnas.0609471104

• Sustainability Science

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    Homogenization of regional river dynamics by dams and global biodiversity implications

    • From the Cover

    N. LeRoy Poff, Julian D. Olden, David M. Merritt, and David M. Pepin

    PNAS April 3, 2007 104 (14) 5732-5737; https://doi.org/10.1073/pnas.0609812104

    See companion article:

    • In This Issue

      - Apr 03, 2007
    • Homogenous rivers, homogenous faunas

      - Apr 03, 2007