Multiple molecular evidences for a living mammalian fossil

Dorothée Huchon; Pascale Chevret; Ursula Jordan; C. William Kilpatrick; Vincent Ranwez; Paulina D. Jenkins; Jürgen Brosius; Jürgen Schmitz

doi:10.1073/pnas.0701289104

New Research In

Edited by Francisco J. Ayala, University of California, Irvine, CA, and approved March 18, 2007 (received for review February 11, 2007)

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Fig. 1.
A juvenile L. aenigmamus, captured and released after photography, provides evidence that this species is, indeed, very much alive. Known locally as Kha-nyou, the Laotian rock rat possesses a rat-like head with long whiskers and a furry squirrel-like tail. It lives in the limestone rock outcroppings of central Lao People's Democratic Republic. (Photo by Uthai Treesucon, David Redfield 2006 Lao expedition, and used with permission from Florida State University Research in Review Magazine).
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Fig. 2.
Phylogenetic hypotheses for L. aenigmamus and Diatomyidae. (A) Based on morphological characters of extant species, Laonastes constitutes a new rodent family at the base of the hystricognaths (2). (B) Based on partial mitochondrial gene sequences, Laonastes constitutes a new rodent family nested within the hystricognaths (2). (C) Based on dental, cranial, and postcranial characters of fossils and extant species, Laonastes is a living fossil of the Diatomyidae family (3). (D) Based on fossil dental evidence, the family Diatomyidae is inferred to be a sister clade of hystricognaths (5). (E) Based on incisor enamel microstructure and cranial characters, Diatomyidae are related to the Pedetidae and Ctenodactylidae (i.e., sciurognathy and hystricomorphy) (6, 7).
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Fig. 3.
Molecular time scale for the order Rodentia. The chronogram was obtained by using the topology of the best ML tree and a Bayesian relaxed clock method with different substitution models for each gene partition. Fossil constraints are indicated by diamonds on the corresponding nodes: 1, 28.5–50 Mya; 2, >37 Mya; 3, 28.5–37 Mya; 4, 37–90 Mya; 5, 55.4–90 Mya; 6, 25–35 Mya; and 7, 63–90 Mya (detailed references are provided in SI Appendix ). The divergence date and the confidence interval of the Laonastes/Ctenodactylidae split are indicated. Circles indicate the phylogenetic support of the corresponding branches. Solid circles indicate branches with maximal support value (ML BP = 100 and Bayesian PP = 1.0); gray circles indicate branches with high support value (100 > BP > 90; PP = 1.0); and white circles indicate nodes with moderate support values (90 > BP > 50; 1.0 > PP > 0.75). Ano., Anomaluromorpha; Cas., Castorimorpha; Cte., Ctenodactylidae; Dia., Diatomyidae; Hys., Hystricognathi; Myo., Myodonta. The terms hystricomorph, myomorph, and sciuromorph indicate both character states and suborders. However, the character states and their corresponding taxonomic divisions disagree. For example, the Gliridae have myomorph characteristics but belong to the sciuromorphs. To avoid confusion, we thus prefer to use the terms, Ctenohystrica, Myodonta, and squirrel-related clade rather than Hystricomorpha, Myomorpha, and Sciuromorpha. CRE, Cretaceous; PAL, Paleocene; EOC, Eocene; OLI, Oligocene; MIO, Miocene; P, PlioPleistocene. Laonastes 25 and 410, specimen vouchers BMNH1998.25 and BMNH1998.410, respectively.
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Fig. 4.
Phylogenetic affiliations of Laonastes based on presence/absence patterns of retroposed SINEs. The phylogenetic tree indicates the three major rodent clades: the mouse-related clade, the Ctenohystrica, and the squirrel-related clade. Eleven retroposed elements, present in certain mouse-related species (blue circles), were clearly absent in Laonastes. Nine other SINEs, present in certain Hystricognathi species (orange circles), were also absent in Laonastes. The monophyly marker of Ctenohystrica was present in all representatives including Laonastes (black circle) and was absent in members of both the mouse- and squirrel-related clades. Four diagnostic markers were present in Laonastes and Ctenodactylus (red circles) but absent in all other investigated rodents. Detailed information on the 11 investigated loci and diagnostic SINE markers are given in SI Appendix .

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Table 1.

Comparison of competing hypotheses using the SH test

Phylogenetic hypothesis	− Ln L	Diff − ln L	P value
Best ML tree	72,989.92	—	—
[Laonastes+ Ctenodactylidae] paraphyly	73,117.72	127.81	0.0002*
[Laonastes+ Ctenodactylidae + Hystricognathi] paraphyly	73,079.93	90.02	0.0253*
[Laonastes + Phiomorpha s.s.] monophyly	73,298.38	308.46	< 0.0001*
[(Laonastes + Pedetidae)+Ctenodactylidae] monophyly	73,326.78	336.87	< 0.0001*
Hystricognathi paraphyly	73,166.14	176.22	0.0001*
Caviomorpha paraphyly	73,107.07	117.16	0.0045*
[Sciuroidea + Gliridae] paraphyly	73,014.30	24.38	0.6169
[Muroidea + Dipodidae + Anomaluromorpha + Geomyoidea + Castoridae] paraphyly	73,022.30	32.39	0.4718

↵*Indicates significant P values.

Data supplements

Huchon et al. 10.1073/pnas.0701289104.

Supporting Information

Files in this Data Supplement:

SI Figure 5
SI Figure 6
SI Figure 7
SI Appendix
SI Table 2
SI Table 3
SI Data Set 1

SI Figure 5

Fig. 5. Best ML tree (-ln likelihood = 72,989.92) obtained for the concatenated data set under the GTR+Gamma+I model of sequence evolution. For each node the ML BP and the Bayesian PP are given to the left and right, respectively, of the slash. Branches with maximal support value (i.e., BP = 100, PP = 1.0) are indicated by black dots. - indicates that the corresponding node was not present in the corresponding Bayesian tree. Laonastes 25 and 410, samples from BMNH 1998.25 and BMNH 1998.410.

SI Figure 6

Fig. 6. Best ML trees obtained for each separate gene. (A) Alpha 2B adrenergic receptor (ADRA2B). (B) Growth hormone receptor (GHR). (C) Interphotoreceptor retinoid binding protein (IRBP). (D) Von Willebrand factor (vWF). (E) Cytochrome b. (F) 12S rRNA. For each node the ML BP and the Bayesian PP are given at the left and right, respectively, of the slash. Branches with maximal support value (i.e., BP = 100, PP = 1.0) are indicated by black dots. - indicates that the corresponding node was not present in the corresponding ML bootstrap consensus tree, or Bayesian tree. Ano., Anomaluromorpha; Cas., Castoridae; Cte., Ctenodactylidae; Der., Dermoptera; Dip., Dipodidae; Geo., Geomyoidea; Gli., Gliridae; Hys., Hystricognathi; Lag. Lagomorpha; Mur., Muroidea; Pri., Primate; Sca., Scandentia; Sci., Sciuroidea. Laonastes 25 and 410, samples from BMNH 1998.25 and BMNH 1998.410. It is worth noting that in all cases the two Laonastes individuals cluster with the Ctenodactylidae, except for the 12S rRNA gene. This is likely to result from the small number of characters (355 bp) considered for this gene, of which about half are constant. Based on Cyt b sequence analysis Laonastes was considered to be the sister clade of Heterocephalus (Bathergidae, Hystricognathi) (1). Our analysis of the same gene, however, shows that Laonastes clusters with the Ctenodactylidae. Discrepancy between our cytochrome b and 12S rRNA results and those of Jenkins et al. (1) have several possible explanations. A longer fragment of the cytochrome b gene (1,104 vs. 401 bp) was considered from which the highly variable third codon position were removed. Additionally, a much broader species sampling was considered. It is worth noting that Ctenodactylidae were not included in the molecular analyses of Jenkins et al. (1).

1. Jenkins PD, Kilpatrick CW, Robinson MF, Timmins RJ (2005) Syst Biodivers 2:419-454.

SI Figure 7 A and B
SI Figure 7 C and D

Fig. 7. Schematic alignments of the four SINE-insertion loci supporting the sister clade relationship of the gundi and Laonastes. For each locus, potential direct repeats are boxed, the partial 5' and 3' ends of the SINE elements are shown in lowercase letters, and the consensus sequences of the elements identified by RepeatMasker are given below the gundi and Laonastes sequences. The lengths of the excised repeat regions are indicated at the diagonal bars. (A) Alignment of locus 14c which contains a diagnostic ID_B1 element in gundi and Laonastes. Note that an additional ID_B1 element is inserted in Laonastes and a B1_Rn element is inserted in the muskrat. (B) Alignment of locus 5c that contains a diagnostic B1F insertion. Laonastes shows an additional insertion of an ID_B1 element. (C) Alignment of locus 5d that contains a diagnostic B1-dID. Note that the B1-dID elements ends in an A-rich 3' region. (D) Alignment of locus 2e that contains a diagnostic B1-dID insertion. Potential direct repeats were difficult to assign and should be considered with caution. For example, an additional ID_B1 insertion is identified in one of the potential direct repeats of gundi. In the gundi there is also an additional ID_B1 insertion. This insertion might be responsible for the deletion of the 5' end of the diagnostic B1-dID element. Detailed alignments are available in SI Data Set. Cricetidae: Cricetus cricetus = Cc (black-bellied hamster), Cricetulus griseus = Cgri (Chinese hamster); Ondatra zibethicus = Oz (muskrat); Muridae: Mus musculus = Mm (house mouse); Rattus norvegicus = Rn (Norway rat); Meriones unguiculatus = Mu (Mongolian gerbil); Spalacidae: Spalax ehrenbergi = Se (Ehrenberg's mole-rat); Dipodidae: Jaculus jaculus = Jj (lesser Egyptian jerboa); Pedetidae: Pedetes capensis = Pca (springhare); Anomaluridae: Anomalurus sp. = Asp (scaly-tailed squirrel); Castoridae: Castor fiber = Cf (Eurasian beaver); Heteromyidae: Heteromys gaumeri = Hg (Gaumer's spiny pocket mouse); Ctenodactylidae: Ctenodactylus gundi = Cgu (northern gundi); Diatomyidae: Laonastes aenigmamus = La (Laotian rock rat); Thryonomyidae: Thryonomys swinderianus = Ts (greater cane rat); Echimyidae: Proechimys cuvieri = Pcu (Cuvier's spiny rat); Myocastoridae: Myocastor coypus = Mc (nutria); Octodontidae: Octodon degus = Od (degu); Caviidae: Cavia porcellus = Cp (domestic guinea pig); Dolichotis patagonum = Dp (Patagonian mara); Erethizontidae: Coendou prehensilis = Cop (Brazilian porcupine); Sciuridae: Sciurus vulgaris = Sv (Eurasian red squirrel), Marmota marmota = Mma (European marmot); Gliridae: Glis glis = Gg (fat dormouse); Lagomorpha: (Lepus europaeus = Le), (Oryctolagus cuniculus = Oc).

Table 2. List of all specimens and GenBank accession nos. for each gene sequenced

	Species	ADRA2B	IRBP	vWF	GHR	Cyt b	12S rRNA
Rodentia
Sciurognathi
Muroidea
Muridae	Mus musculus	M94583	AF126968	U27810	AJ238390	NC_005089	NC_005089
	Rattus norvegicus	M32061	AJ429134	AJ224673	X16726	AC_000022	AC_000022
Spalacidae	Tachyoryctes sp.(1)	AJ427264	AJ427231	AJ402713	AY294900	AF160602	AM407910*
	Spalax sp. (2)	AM407905*	U48589	U31621	AY294898	NC_005315	NC_005315
Dipodidae	Dipus sagitta	AJ427263	AJ427232	AJ224665	AM407908*	AM407909*	AJ3119807
	Jaculus jaculus	AM407906*	AM407907*	AJ297765	AF332040	NC_005314	NC_005314
Geomyoidea
Heteromyidae	Dipodomys sp. (3)	AJ427261	AJ427233	AJ427226	X	AY926383	AY012119
Geomyidae	Thomomys sp. (4)	AJ427262	AJ427234	AJ427227	AM407911*	AF215812	AM407912*
	Geomys sp. (5)	AM407913*	AM407914*	AM407915*	AF332028	AY926386	AF084294
Gliridae	Glis glis	AJ427258	AJ427235	AJ224668	AM407916*	NC_001892	NC_001892
	Dryomys sp. (6)	AJ427257	AJ427236	AJ224666	AY294896	AJ225116	AJ225119
Sciuroidea
Sciuridae	Marmota monax	AJ427255	AJ427237	AJ224671	AM407917*	AF157953	AY227529
	Sciurus sp. (7)	AJ315942	AY227620	AM407918*	AF332032	NC_002369	NC_002369
Aplodontidae	Aplodontia rufa	AJ427256	AJ427238	AJ224662	AF332030	AJ389528	AJ389541
Castoridae	Castor sp. (8)	AJ427260	AJ427239	AJ427228	AF332026	AJ389529	AY012111
Anomaluromorpha
Anomaluridae	Anomalurus sp.	AJ427259	AJ427230	AJ427229	AM407919*	AJ389526	AJ389539
Pedetidae	Pedetes sp. (9)	AM407920*	AJ427241	AJ238389	AF332025	AJ389527	U59171
Ctenodactylidae	Massoutiera mzabi	AJ427265	AJ427242	AJ238388	AM407921*	AJ389533	AJ389544
	Ctenodactylus sp. (10)	AM407922*	AM407923*	AJ238387	AF332042	AJ389532	AJ389543
Diatomyidae	Laonastes aenigmamus BMNH 1998.25	AM407899*	AM407903*	AM407897*	AM407901*	AM407933*	AM407931*
	Laonastes aenigmamus BMNH 1998.410	AM407900*	AM407904*	AM407898*	AM407902*	DQ139933*	AM407932*
Hystricognathi
Thryonomyidae	Thryonomys swinderianus	AJ427267	AJ427243	AJ224674	AF332035	NC_002658	NC_002658
Petromuridae	Petromus typicus	AJ427268	AJ427244	AJ251144	X	DQ139935	M63571
Bathyergidae	Bathyergus suillus	AJ427252	AJ427251	AJ238384	X	AY425913	AY427020
	Heterocephalus glaber	AM407924*	AM407925*	AJ251134	AF332034	AF155870	AY012120
Hystricidae	Trichys / Hystrix (11)	AJ427266	AJ427245	AJ224675	AF332033	X70674	U12448
Caviomorpha
Chinchillidae	Chinchilla lanigera	AJ427271	AJ427246	AJ238385	AF332036	AF464762	AF520696
Dinomyidae	Dinomys branickii	AM050859	AM050862	AJ251145	AF332038	AF122820	AY012124
Echimyidae	Echimys / Proechimys (12)	AJ427269	AJ427247	AJ251141	AF332039	L23341	AF422877
Capromyidae	Capromys pilorides	AM407926*	AM407927*	AJ251142	AF433949	AF422915	AF433926
Octodontidae	Octodon sp. (13)	AM050860	AM050863	AJ238386	AM407928*	AM407929*	AM407930*
Caviidae	Cavia porcellus	AJ271336	AJ427248	AJ224663	AF238492	NC_000884	NC_000884
Agoutidae	Agouti paca	AM050861	AM050864	AJ251136	AF433928	AY206571	AY093664
Erethizontidae	Erethizon / Coendou (14)	AJ427270	AJ427249	AJ251135	AF332037	U34852	AY012118
Lagomorpha
Leporidae	Oryctolagus cuniculus	Y15946	Z11812	U31618	AF015252	NC_001913	NC_001913
	Lepus sp. (15)	AJ427254	AJ427250	AJ224669	AF332016	NC_004028	NC_004028
Ochotonidae	Ochotonaprinceps	AJ427253	AY057832	AJ224672	AF332015	NC_005358	NC_005358
Primates
Hominidae	Homo sapiens	M34041	J05253	M25851	X06562	NC_001807	NC_001807
Cercopithecidae	Macaca mulatta	AM050852	AJ313476	AJ410302	U84589	NC_005943	NC_005943
Lemuridae	Lemur / Eulemur (16)	AJ891067	AJ313470	AJ410292	AF540627	NC_004025	NC_004025
Dermoptera
Cynocephalidae	Cynocephalus variegatus	AJ251182	Z11807	U31606	AF540625	NC_004031	NC_004031
Scandentia
Tupaiidae	Tupaia sp. (17)	AY150333	Z11808	AF061063	AF332018	NC_002521	NC_002521
Carnivora	Canis familiaris	XM_849354	XM_546201	U66246	NM_001003123	NC_002008	NC_002008

ADRA2B, alpha 2B adrenergic receptor; GHR, growth hormone receptor ; IRBP, interphotoreceptor retinoid binding protein; vWF, von Willebrand factor; cyt b, cytochrome b; 12S rRNA, small ribosomal subunit RNA.

*Newly determined sequences. X: gene regions where sequences were not obtained.

Tachyoryctes sp. (ADRA2B, IRBP, vWF, 12S rRNA) and Tachyoryctes splendens (GHR, cyt b).

Spalax zemni (IRBP, vWF) and Spalax ehrenbergi (ADRA2B, GHR, 12S rRNA, cyt b).

Dipodomys merriami (ADRA2B, IRBP, vWF, 12S rRNA) and Dipodomys heermanni (cyt b).

Thomomys talpoides (ADRA2B, IRBP, vWF, cyt b) and Thomomys bottae (GHR, 12S rRNA)

Geomys breviceps (ADRA2B, IRBP, vWF, 12S rRNA, cyt b) and Geomys bursarius (GHR).

Dryomys nitedula (ADRA2B, IRBP, vWF, 12S rRNA, cyt b) and Dryomys sp. (GHR).

Sciurus vulgaris (ADRA2B, IRBP, 12S rRNA, cyt b), Sciurus aestuans (vWF), and Sciurus niger (GHR).

Castor canadensis (ADRA2B, IRBP, vWF, GHR, 12S rRNA) and Castor fiber (cyt b).

Pedetes surdaster (IRBP, vWF, 12S rRNA, cyt b) and Pedetes capensis (ADRA2B, GHR).

Ctenodactylus vali (IRBP, vWF, 12S rRNA, cyt b) and Ctenodactylus gundi (ADRA2B, GHR).

Trichys fasciculata (ADRA2B, IRBP, vWF) and Hystrix africaeaustralis (GHR, 12S rRNA, cyt b).

Echimys chrysurus (ADRA2B, IRBP, vWF, 12S rRNA, cyt b) and Proechimys longicaudatus (GHR).

Octodon degus (ADRA2B, IRBP, GHR, 12S rRNA, cyt b) and Octodon lunatus (vWF).

Erethizon dorsatum (ADRA2B, IRBP, GHR, vWF, cyt b) and Coendou bicolor (12S rRNA).

Lepus crawshayi (ADRA2B, IRBP, vWF), Lepus capensis (GHR), and Lepus europaeus (12S rRNA, cyt b).

Lemur catta (ADRA2B, IRBP, vWF, 12S rRNA, cyt b), and Eulemur coronatus (GHR).

Tupaia belangeri (ADRA2B, GHR, 12S rRNA, cyt b), Tupaia glis (IRBP, vWF).

Table 3. Characteristics of the analyzed data sets

Gene	Length, bp	No. of informative characters	No. of constant characters	Best model selected by AIC in Modeltest
ADRA2B	1,152	514	520	TVM+I+G
GHR	873	505	268	K81uf+I+G
IRBP	1,272	649	453	GTR+I+G
vWF	1,239	674	409	GTR+I+G
12S rRNA	355	161	162	GTR+I+G
Cyt b (positions 1+2)	756	248	419	GTR+I+G
Concatenate data set	5,647	2,751	2,231	GTR+I+G

SI Data Set 1

Sequence Alignments of the 25 Phylogenetic SINE Markers in FASTA Format

Cricetidae: Cricetus cricetus = Cc (black-bellied hamster), Cricetulus griseus = Cgri (Chinese hamster); Ondatra zibethicus = Oz(muskrat); Muridae: Mus musculus = Mm (house mouse); Rattus norvegicus = Rn (Norway rat); Meriones unguiculatus = Mu (Mongolian gerbil); Spalacidae: Spalax ehrenbergi = Se (Ehrenberg's mole-rat); Dipodidae: Jaculus jaculus = Jj (lesser Egyptian jerboa); Pedetidae: Pedetes capensis = Pca (springhare); Anomaluridae: Anomalurus sp. = Asp (scaly-tailed squirrel); Castoridae: Castor fiber = Cf (Eurasian beaver); Heteromyidae: Heteromys gaumeri = Hg (Gaumer's spiny pocket mouse); Ctenodactylidae: Ctenodactylus gundi = Cgu (northern gundi); Diatomyidae: Laonastes aenigmamus = La (Laotian rock rat); Thryonomyidae: Thryonomys swinderianus = Ts (greater cane rat); Echimyidae: Proechimys cuvieri = Pcu (Cuvier's spiny rat); Myocastoridae: Myocastor coypus = Mc (nutria); Octodontidae: Octodon degus = Od (degu); Caviidae: Cavia porcellus = Cp (domestic guinea pig); Dolichotis patagonum = Dp (Patagonian mara); Erethizontidae: Coendou prehensilis = Cop (Brazilian porcupine); Sciuridae: Sciurus vulgaris = Sv (Eurasian red squirrel), Marmota marmota = Mma(European marmot); Gliridae: Glis glis = Gg (fat dormouse); Lagomorpha: (Lepus europaeus = Le), (Oryctolagus cuniculus = Oc). Additional mouse, rat, Chinese hamster, guinea pig, and rabbit sequences were obtained from the National Center for Biotechnology Information GenBank (NG_001340, AB074009, Y12838, AJ511868, AF367373, AJ001307, AF220498, AC122428, AB019029, AB053221, NW_047817, NW_047813, NW_047563, NW_047334, NW_047696, NW_047663, NW_047799, NW_048034, NW_047718, U09453; TDB = trace sequences (National Center for Biotechnology Information).

All other sequences have been submitted under accession numbers DQ321375-DQ321487, DQ451018-DQ451089, DQ521259-DQ521268, EF052254-EF052265. Small letters represent diagnostic SINEs. The abbreviations for SINEs are taken from the RepeatMasker outfiles (www.repeatmasker.org/cgi-bin/WEBRepeatMasker).

Locus 463-1

>B1_Mur1

--------------------------------------------------

------------------agccgggcgtggtggcgcacgcctttaatccc

agcactcgggaggcagaggcaggcggatctctgtgagttcgaggccagcc

tggtctacatagcgagttccaggccagccagggctacatagtgagaccc-

tgtctcaaaaaaacaaaa--------------------------------

--------------------------------------------------

--------------------

>Mm

GACCAACTACAAGACCATCGGCCTGAGCACAGCTGCTCGATTCAACCAGT

GCAA---------------TGAGGTCTTCTCAGTGATGCACTGTG---CA

AAGAGAGAAG--GTA---agccaggcatggaggcacacaccattcatccc

agcagttgggaggcagaggcaggcaga----tttgacttcaagaccagcc

tggtctacatagtgagttccaggccagccagagctacatagcaagaactt

gtgcacaaacaaacaaacaaaca---AACAAAAACTAAGTG---GGTTA-

GGACCAGGCTAAGGAGCTAGAGCAGGCTTGGAGCA------------CCT

GATTCC-TGTCATTTCTAG--GCAAGTCTGTGGGAGTGGTGACCGCCACG

TCGGTGCAGCACGCCTCTCC

>Rn

AGCCAACTACAAGACCATCGGTGTGAGCGCGGCTGCTCGATTCAACCAGT

GCAACAGCACATTTGGCAACGAGGTCTTCTCAGTGATGCACCGTG---CA

AAGAAAGCAG--GTG---agccgggcatgaaggtacacaccattaatccc

agcagttgggagacagaggcaggcaga----tctgacttcaaggccagtc

tggtctatatagtgagttccaggccagccagggctacatagcaaggactt

atgcaaaaacaaacaaacaaaca---CA---------AGTG---AGTCG-

GGGCCAGGCTAAGGAGCTAGAGCAGGCTTGGAGCAGTAGGTGGCCCACCT

GATCCC-TGTCATGTCTAG--GGAAGTCTGTGGGAGTGGTGACCACCACG

TCGGTACAGCATGCCTCTCC

>Mu

GGCCAACTACAAGACCATCGGCGTGAGCGCAGCTGCGCGAGTCAGCCAGT

GCAACACCACATTTGGCAACGAGGTCTTCTCGGTCATGTATCGGG---CA

AAGAAAGCAG--GTG---agctgggg------------------------

--------------------------------------------------

------------------ccaggcccggggatggggcgggcccgggg---

--------------------------CAAAGAAGGCAGGCA---GGTTG-

GTGCTGGGCTTGGGAGCTAAGGCAGACCTGGATCACTCAGTG--------

--ATCTTCTATCCCGCCAG--GGAAGTCTGTGGGGGTGGTGACCACCACC

AGGGTGCAGCACGCCTCTCC

>Cc

GGCCAACTACATGACCATTGGTGTGAGCGCAGCAGCCCGAGTTGACCAGT

GCAACACCACATTTGGCAATGAGGTCATCTCAGTGATGTATCGTG---CA

AAGAAAGCAG--GTA-----------------------------------

--------------------------------------------------

--------------------------------------------AGTTG-

GTGCTGGGCTTGGGAGCTCGGGCAGGTCTGGATCACTCACTGGGTGACAT

----CC-TATCATCTACAG--GAAAGTCTGTGGGAGTGGTCACCACCACC

AGGGTGCAGCATGCCTCTCC

>Oz

GGCCAACTACATGACAATTGGTGTGAGCGCAGCAGCCCGAGTTAACCAGT

GCAACACCACATTTGGCAATGAGGTCATCTCAGTGATGTATCGTG---CA

AAGAAAGCAG--GTA-----------------------------------

--------------------------------------------------

--------------------------------------------GGTTG-

GTGCTGGGCTTGGGAACTCGGGCAGGTCTGGATCACTCACTGGGTGACAT

----CC-TTTCATCTACAG--GAAAGTCTGTGGGAGTGGTCACCACCACC

AGGGTGCAGCATGCCTCTCC

>Jj

GGCCAATTACAAGACCATCGGCTTGAGTGCGGCTGCCCGTGTTGACCAGT

GCAACACGACTTTTGGCAATGAGGTCCTCTCCGTGATGTACCGCG---CC

AAGAAAGCCG--GTG-----------------------------------

--------------------------------------------------

--------------------------------------------AGTTGG

GGGCTGGGCCCAGGGACAGGGGCATGCCCTGGGCACTCCATGTCTCACCT

-GACTTCTGCCACCATCAG--GGAAGTCCGTGGGTGTGGTGACCACCACC

CGGGTGCAGCACGCCTCTCC

>Pca

AGCCAACTACAAGACCATCGGCTTGAGCGCCGCCGCCCGCTTTGACCAAT

GCAACACCGCACGAGGCAACGAGGTCCTCTCCGTGATGTACCGCG---CC

AAGAAAGCAG--GTG-----------------------------------

--------------------------------------------------

--------------------------------------------GGCCAG

GGGCCGGGCTGCGGGACGGGG-CAGGCCTGGAGCACCACGTGACCCACCC

TGACCTCTGCCACTTCCAG--GCAAGTCCGTGGGAGTGGTGACAACCACA

AGGGTGCAGCACGCCTCGCC

>La

GGCTAACTACCAGACCATCGGTGTGAGTGCAGCTGCCCGGGTTGACCAGT

GCAACACAACACGTGGCAACGAGGTCATCTCCGTGATGTACCGTG---CC

AAAAAAGCAG--GTA-----------------------------------

--------------------------------------------------

---------------------------------------------TGCTA

GGGCTAGGATTGGGGACAGGA-GGGGCTT-----CAATGGCTTGGAACAC

TGG-CTCTATCACCTTCAG--GAAAGTCTGTGGGAGTAGTGACCACTACC

AGGGTACAGCACGCCTCGCC

>Pcu

AGCCAACTACAAGACCATCGGCTTGAGCGCCGCCGCCCGCTTTGACCAAT

GCAACACCGCACGAGGCAACGAGGTCCTCTCCGTGATGTACCGCG---CC

AAGAAAGCAG--GTG-----------------------------------

--------------------------------------------------

--------------------------------------------GGCCAG

GGGCCGGGCTGCGGGACGGGG-CAGGCCTGGAGCACCACGTGACCCACCC

TGACCTCTGCCACTTCCAG--GCAAGTCCGTGGGAGTGGTGACAACCACA

AGGGTGCAGCACGCCTCGCC

>Cp

AGCCAACTACCAGACGATCGGCCTGAGTGCGGCTGCTCGAGTCAGTCAGT

GCAACACAACCCGGGGCAACGAGGTCCTCTCCGTGATGTACCGGG---CC

AAGAAAGCAG--GTG-----------------------------------

--------------------------------------------------

--------------------------------------------GGTTTG

AGGCCAGCCTTGGGGACAAGAGTGTGCCCAAAGACCTGAGACACCCACTG

AGTCCTCTCTCTTCTGCAG--GGAAGTCTGTGGGGATAGTGACCACCACC

AGGGTCCAGCACGCCTCTCC

>Oc-TDB

GGCCAATTACAGGACCATCGGCATGAGTGCGGCCGCCCGCTACGACCAGT

GCAACACAACCCAGGGCAATGAGGTGCTCTCGGTGATGTACAGGG---CC

AAGAAGGCAG--GTG-----------------------------------

--------------------------------------------------

--------------------------------------------GGCTGG

GCGCACGGCGTGGGATGGGGA------GGGGAGACACCTGGGCCCCACGC

TGACCTGTGCCTCCCTCAG--GGAAGTCCGTGGGAGTGGTGACCACCACG

CGGGTGCAGCACGCCTCGCC

Locus 25-2

>B1-dID

--------------------------------------------------

----------gctgaggttttttttctcatggtcaatgctcattttattt

tttgggaggtgtactggggatggaactcaggggcactcaaccacatcctc

agccctattttgtattttat------------------------------

----------------------------------ttagagacagggtctc

actgagtgctt---agcactttgcttttgcagaggctggctttgaacttg

caatcctcctgcctcagcctcccaagccactggga---------------

--------------------------------------------------

-----------------------ttacaggtgtgcaccactgcaccctgc

tcaatatttacttttattcttaattttct---------------------

--------------------------------------------------

------------------------------

>B1

--------------------------------------------------

-ttttgtttttttgagacagggtctcactatgtagcccaggctggcctgg

aactcactatgtagcccaggctggcctcgaactca--------cggcaat

cctcctg---cctcagcctcccgagtgctgggattacaggcatgagccac

cacgcccggct---------------------------------------

--------------------------------------------------

------------------------------

>ID2

--------------------------------------------------

tgaagtttttttgcggtgctgaggatcgaacccagggcctcgcgcttgct

aggcaagcgctcta-c-cactgagctacatccccagcccc----------

--------------------------------------------------

------------------------------

>B1F1

--------------------------------------------------

----------------------------------------------tttt

gtttttttgagacagggtctcactatgtagccctggctggcctggaactc

actatgtagcccaggctggcctcgaactca-----cggcgatcctcctgc

ctcagcctcccgagtgctgggattacaggcgtgtgccaccacgcccggct

--------------------------------------------------

------------------------------

>B1

--------------------------------------------------

-------------------------------------------ttttgtt

tttttgagacagggtctcactatgtagcccaggctggcctggaactcact

atgtagcccaggctggcctcgaactcacggcaatcctcctgcctcagcct

cccgagtgctgggattacaggcatgagccaccacgcccggct--------

--------------------------------------------------

------------------------------

>Mm

CTCTACATGTT--CTGAAAGCACAGCCAGA--CTGGTTAGGGA-AT----

AAAGAACG------------------------------------------

--------------------------------------------------

---------------GGACCAGCTCTTCTCTCCCTAG-------------

--------------------------------------------------

-----------------------------------------------TGC

CTCAGTCAGCCCAGGACCCCCAACACAT-------------CATCACGCC

CTCA----------------------------------------------

--------------------------------------------------

------------------------TTATTGCCAGGTCTGCCCATTCCC--

-AAGTCTAGTGAGACAGCATTTCACTTAG---------------------

--------------------------------------------------

----------------ATTCTGAAGTCCA-------CAAAATCTCAGGTA

ACGAAC--------------------------------------------

--------------------------------------------------

TTTTTAGGAATAAAGTGAT-------------------------------

--------------------------------------------------

-------------------------------------CCTG---TTT---

---GGGGGTGAGGGGGAGAATGGGGGGCATTGTATTCGGTT---------

----------------tttctctgtg-cagccctgactctcctggaattt

gctctgtagaccagga--------------------gaccaccagcctgc

ctctgcctcatgagcgctgggattaaaggtgtgcaccaccatgcccagtt

----------------------------CTTACTAGTTTTTGGTAATTAT

TTCTAAATG---------AAGGAATGAGCTTTGGTTGTTTTTGT------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATAGAGCTGTGGCTGCTC

AATGCGGCGGCTCCCTCCTCATCTTCATCC

>Rn

CTCCACATGTT--CTGAAAGCACAGCAC-AGGCTGGTCAGGGA-GT----

GC------------------------------------------------

--------------------------------------------------

---------------GGACCAG----CTCCTGAGTCA-------------

--------------------------------------------------

----------------------GCTGGGAC---CAACGCAGC--CAGGTC

CACG----------------------------------------------

--------------------------------------------------

------------------------TTACTGCCACAGCTACCCAGTCCC--

-AAATCCAGTGGAATAGCATTTCACTTAG---------------------

--------------------------------------------------

----------------ATTCTGAAGTCCA-------CAAAATTTCAGTTA

ACAAAG--------------------------------------------

--------------------------------------------------

-----------------------------------------------TCC

TTCTTAGGAATAAAGTGAT-------------------------------

--------------------------------------------------

--------------------------------------CTGTTTTTTGGG

GGTGGGGGTGGGAGTGGAGGTGGGGG---TTGTATTT-GTT---tttttt

tttttcaagataagac-ttctctttg----------------tagaattt

gatctgtagacccagatggcctcaaactcagagaccaacctgcctcttgc

ctctgcctcatgatt-ctgggattaaaggtgtctaccaccatgcccagtt

-----CTTACTGGTTCTAAGCC------AATCCCTTTTCTTCATGATTAT

TCCTAAATG---------AAAGAATGAGTTTTGGTTTTTGTTTT------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATGGAGCTGTGGCTGCTC

AATGCTGCAGCTCCCTCCTCATCTTCATCC

>Mu

CTCTACGTGTT--CTGAAAGCATAGCCGAAGGCTGGTTAGGG-GAT--AG

GTACAATG------------------------------------------

--------------------------------------------------

---------------GGACCACTTCCTCTCTCTATTC-------------

--------------------------------------------------

-------------------------------------------------C

TTGAATCAACCCAGGACTCCT-GGAGT--------------CATCAAGTC

CACG----------------------------------------------

--------------------------------------------------

--------------------TGCTGTACTGCCAGGTTTCCC---------

------------AGATCTAGCTACCCTAG---------------------

--------------------------------------------------

----------------ATTCTGA---------------------------

--------------------------------------------------

--------------------------------------CTG---------

-------------------------------------------------g

ttcttagagacaag-cttactctgcaacagccctggccgtcctggaactt

aatttgtagaccaggctggcc---------tca---aactcaacagatct

gcaggcctc-----tgctgggactaaaggtgtgtgccaccatgcccggct

---ACGACTAAGGCAA------------CCCACTT--CCTACATAATTAA

TCCTAAATC---------AAAGAATGAGCTTT------------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATAGAGCTGTGGCTGCTC

AATGCTGCAGCTCCCTCCTCATCTTCATCC

>Cc

CTCCACGTGTT--CTGAAAGCATAGCCACAGGCTGATTAGGGA-AT----

-GACGGT-------------------------------------------

--------------------------------------------------

---------------GGACCAGTTCCTCTCCCTATTT-------------

--------------------------------------------------

-------------------------------------------------C

CTGAATCA-------------------GGGAAT--------TACCAACTC

CACA----------------------------------------------

--------------------------------------------------

------------------------TTATTGTCAAGTCTAGCTAAGCAT--

-CCCACC-------------------TAG---------------------

--------------------------------------------------

----------------ATTCTGAAAATCTGCTAA--CAAAC---------

--------------------------------------------------

-----------------------------------------------TTC

CTTCTAAGAGTAAGGTGGTA---agccgggcgttggtggcgcacgccttt

aatcccagcactcgggaggcagaggcaggcggatctctgtgagttcgagg

ccagcctggtctacagagtgagttccaggacagcctccaaaacaataca-

--GAGAAACCCTGTTTCGAAAAAAAGTAAGGTGGTGCGCTGAGACTT---

--------------------------------------------------

---TTCTTACTGG-TCTAAACC------GATGTGTTTCCTTCATGGGTAT

TCGCAAATG---------AGAGGAGGAGCCTTTTT---------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATAGAGCTGTGGCTGCTC

AGTGCTGCAGCCCCCTCCTCTTCCTCATCC

>Oz

CTCCACGTGTT--CTGAAAGCACAGCCACAGGCTGGTTAGGG-CAT--AG

AGACAACCC-----------------------------------------

--------------------------------------------------

---------------GGAACCCTT--GACTCATGGAG-------------

--------------------------------------------------

--------------------------------T--------CACCAATTC

CACA----------------------------------------------

--------------------------------------------------

------------------------TTATTGCCAAGTCT-ACCATTCCC--

-AAATCTAGCTAAATAGCATTTCACCTAC---------------------

--------------------------------------------------

----------------ATTCTGAAGTCTG-------CAAAAA-TTTGTTA

ACAAAC--------------------------------------------

--------------------------------------------------

-------------------------------------------TTCCTTC

TTTTTAAGGGCAAGATGGTC------------------------------

--------------------------------------------------

------------------------------------CTCTGTTACTT---

--------------------------------------------------

---TTCTTACTGGTTTTAATCC------GGTCTGTTTCCTTCTTCATTAT

TCCCAAATG---------AAAGGATGAGCTCCTT----------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATAGAACCGTGGCTGCTC

AGTGCTGCAGCTCCCTCCTCATCTTCATCC

>Jj

CTCTACATGTT--CTGAAATCACAGCCAGAGGCTGGTTAGGG-GAT----

AGACAATG------------------------------------------

--------------------------------------------------

---------------GGACCAGCTTCTCTTCCCATTC-------------

--------------------------------------------------

-------------------------------------------------C

ATGAATCAACCCAGAGCCCTCATCTGATGATGGT-------CACCAAGTC

CATC----------------------------------------------

--------------------------------------------------

---------------------CTCTTACAGCGAGCCTGGTCATTCTCA--

-AACCTAGCAGGATAAGTAATTCTCCTGC---------------------

--------------------------------------------------

----------------ATTCTGAATG----------CAAACTACCTTTAT

--------------------------------------------------

-----AGAAATAAGACGTTC------------------------------

--------------------------------------------------

------------------------------------CTCTGTAACTT---

--------------------------------------------------

---CTCTTCCTGGCTCAGACT------AG-TCCATTTTCTTCATAATTAT

TCCCAAATG---------AA--ATTATTTATTTTTTT-------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGAATAGAGCTGTGGCTGCTT

AGTGCTACAGCCCCCTCCTCCTCTTCATCT

>Pc

CTCAACATGTT--CTGAAATCACAGCCAGAGGCTGGTTAAGG-GAC--AG

AAACAATG------------------------------------------

--------------------------------------------------

---------------GGACGAGGTCATCTCCCCATTT-------------

--------------------------------------------------

-------------------------------------------------C

TTGAATCAACCCAGAACTCATGGTT-TGGTGGC--------TAATGGAAC

CACC----------------------------------------------

--------------------------------------------------

-----------AAATCTATCTGG-TTATTGCAAGCATG-CCCATCCCC--

-AAGTCTAGTAGAATAGCATTTCATCTTT---------------------

--------------------------------------------------

----------------T-TCTGAAGTCTG-------CAAA----------

--------------------------------------------------

------------------------------------------CTATCTTT

TTT--AGGAATAAGTTGTTC------------------------------

--------------------------------------------------

------------------------------------CTCTGTAACTTC--

--------------------------------------------------

---CCTCTATGGGCTCAGGCA------ACTCACTTTTCC-TCATAATTAT

TTCCAAATG---------AAA-CTGATTTTTGTTTTT-------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGAATAGAGCTGTGGCTGCTC

AAAGCTGTGGCTCCCTCCTCATCTTCATCC

>Asp

CTCTACATGTT--CTGAAATCACAGCCAGAGGCTGGTTAGGG-GAC--AG

AAACAATG------------------------------------------

--------------------------------------------------

---------------GGACCAGCTCCTCTCCCCATTT---ctttctttcg

agacagggtcttgctaagttacacaggctgcctctggcgtcaaacctgcc

tctgcctcctgagtctgggattacaggcatcaccacacccagcatctttt

tatgtggtgctggggattgaacccagggccttgcgcatgctaggcaggca

ctctaccaactgagctacacctccagcccc---TATCCTCATTT-----C

TTGAATCAACCCAGAGCTCTTCATTAATGAAGC--------CACCAAATC

CATC----------------------------------------------

--------------------------------------------------

----------------TGCTTATTGCTAGCA-----TG-CCCACCCCC--

-AAGTCTAATAGAATAGTATTTCATCTGA---------------------

--------------------------------------------------

----------------T-TCTGAAGTCTG-------CAAAC---------

--------------------------------------------------

---TACCTTTTT---AGGAATAAGGTGTTC------CTCTGTAACTTC--

--------------------------------------------------

---CCTCTACTGGCTCAGGCC------AGTCCATTTCCTTC-ATAATTAT

TTCCAAATG---------GAAGAATGATCTTTTTCTT-------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGAATAGAGCTGTGGCTGCTT

AAAGCTATGGCTCCCTCTTCATCTTCATCC

>Hg

CTCTACGTGTT--CTGAAATCACAGCCAGAGGCTGGTTAGGA-GAT---G

ACAGAATG------------------------------------------

--------------------------------------------------

-------------------------CACTCATTCCTT-------------

--------------------------------------------------

--GAGTCAACCCAGAGC-CCT-----------------------CGACTG

ACTG----------------------------------------------

--------------------------------------------------

-------------------------------------GGTCATCTCCA--

-AGCT-----------TAATAGAACAGGA---------------------

--------------------------------------------------

----------------TTGCTGAAGTTTA-------CAAAC----AGGTT

CACAAAT-------------------------------------------

--------------------------------------------------

-------------------------------------------TACGTTT

TT---AGGAACGGGGTATTT------------------------------

--------------------------------------------------

------------------------------------TTTACTAACTTC--

--------------------------------------------------

---GTTCTAATAGCCT-GGCC------TATCCATTTCCTCT-ACAATTAT

TCCCAAATG---------AAAGAACGTTCTCTCTC---------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGAATGGAGCTGTGGCTGCTC

AATGCTGTTGCTCCCTCCTCGTCTTCATCC

>Cgu

CTCAACATGTT--CTAGAATCAAAC-GGAAGGCCGGTTAGGG-CATA-GA

GA-CA---------------------------------------------

--------------------------------------------------

---------------CAGAGCCC---AGCTGTTCTTG-------------

--------------------------------------------------

----CTCCACCCACAGGCCTTGACCAGCGGG--TCATCCAACATCAAATC

CAGC----tttttttttttttttgaagacagggtttcaccctctagtcca

ggctggacctcaagtagcccagactagttttggactcaatactcctgcct

cggcctcccaggtgctaggattacaggcatgcgtcatcatgcccagctta

cgtggtgttgggaaattgaacttggtacttcgagcttgcttggcaagtgc

ttttaacccctatccttccagcccc---------aat-tccttttgtttt

gtggt-------atccgaaattgaacccaagg------------------

------------------------ctataacaaaaacctaaattc-ctag

ccttttaattttatttttattttacttt------tttgaggaagaggct-

---------------aagttgcccaggctggactc------tttaacttc

tgatcatcctgcctcagcctttcaaaatgctagga---caggggctggag

gaatggcacagcggttaaagcgcttgccttccaagtacaaggccatgaga

ctgattccccagcaccacacacagctgggtgtcatgacacatgcctgtga

tcccagcactcagaaggctgaggcaggcagactgttctgagtccaaggcc

agcctggaatacaccagtgagttcagaaataagcctgggttgcagagcaa

gaccctgtctcaaaaaagaa------------------------------

--------------------------------------------------

--------------AAATCTTCAAGTGTTT------CCTTGACACTTG--

--------------------------------------------------

---TCTCTACTGGCTC-TACC----------------------AGGTGGT

TCCCAAAGGGGGGGA---AAAAAAAGTGATCTTTTTGT------------

--------------------------------------------------

--------------AC--CTGGATCCATGGGAATGGAACTGTGGCTGCTC

AGGGCTGAGGCTCCTTC---ATCCTCATCC

>La

CTCTACATGCT--CTGAAATGACAGCCAGGAGCTGGTTAGGGGC----AA

AGACAATG------------------------------------------

--------------------------------------------------

---------------GGACC------AGCTCTTCTCA-------------

--------------------------------------------------

TTCCTTCAACCCACAGGTCTTGACGGGCGGG-AT-------CATCAAACT

CATC----------------------------------------------

--------------------------------------------------

-----------------------------tttttaat-tccatttgtttt

gtgcc-------actgggggctgaccccacggtcatcacactgagctaaa

taactggcctttttaaaca------aacactga---gttaaataa-ctgg

cctttttaagcaaaa----atttgc---------tttgagacaaggtctt

gctgagttgct----gaattacctaggctgaagtc--------caacttg

tgatcctcctgcctcagcct--cagaatgctagga---------------

--------------------------------------------------

-----------------------ttacagatgtgcaccaaccacactcag

ctcatt---------TGGTTAATTTCTAGGCAAGCTTG-CCCACCCA---

-AACTGAACACCACTTT-----ACCTGGA---------------------

--------------------------------------------------

----------------TT-CTAAAGT----------CAA--GTCTTAGTC

TACAAAC-------------------------------------------

--------------------------------------------------

---TACCTTTT---AAAGGGTCGAATGTTT------TCTTAAAATTTC--

--------------------------------------------------

---CATCTACTGCCTCAGACC----------------------AGGCAGT

TTCC-AAGG---------TAAAGAA-TGATCTTTTTGT------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGAATGGAACTGTGACTGCTC

AGTGCTGTGGCACCCTC---ATCTTCATCC

>Ts

CTCCACATGCT--CTGGAATCACAGCCATAGGCTCATTAGG--TAG-TGG

CAACAATA------------------------------------------

--------------------------------------------------

---------------GGACCAGC---TCTTGTCATTC-------------

--------------------------------------------------

---CTTCAACCCAAAG-TCCAGGACTGGTGG--T-------CACCAAATC

CATC----------------------------------------------

--------------------------------------------------

---------------TTGATAATCTGTAGGCAAGCCTGGCCCACCCTC--

-ATGTCAGAATAATTTATAAGGTACCTTTG--------------------

--------------------------------------------------

---------------TAGACATAAGGTGTTT----------CCCTGAAAC

TTCCTGTTACTGGCTCAGGGC----------AGTGCACTTCAT-CATAAT

TACTGAATGAAAG------CAAATATTCTTT-------------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATGGAACTGTGGCTGCTC

AGTGCTGCGGCTCCCTCCTCATCTTCATCC

>Pcu

CTCTACATGCT--CTGAAATCACAGCCATAGACTGATTAGAAAGAT--GA

CAACAATG------------------------------------------

--------------------------------------------------

---------------GGACCACT---ACTTGTCATTC-------------

--------------------------------------------------

---------------------------------------------TGTCA

TTCATTCAATGCAAAG-T-----------------------CACCAAATC

TACC----------------------------------------------

--------------------------------------------------

---------------TTGGTAAT-TGCAGACAAGCCTGGCCCACCCCCAG

G-----------------TACCAATAGT---AATTCTGAATTCTTA---t

tttttgtttctctgaaacagtttc--act--gtagttcaggctggccttg

aactcagtgtgtagcccaggctgggttcaaacaca----------gtgat

cctcctg---cctcagcctcctgag----------catgcaccatcacac

ccagccagc------AATTCTGAATTCTGAGC------------------

--------------------------------------------------

-------------------------------------------GAAGTAC

TTGAAAAAAAAAATTTTTTT---tt--ggtaccaggaatcaaactcagga

gaacttgtgcttgctaggtaggcactttag-ccctgccc----ACAAAGT

ATAGTTCT------GAGAA-CAAGGCGTTT------CTCTGAAACATC--

--------------------------------------------------

---ACAGTA-TGGCTCAGGTC----------TGTGCAGTGTATC-ATGAT

TTCTGAATG---------AAAGCAGAGG----------------------

--------------------------------------------------

------------------------------------ttcccactccctat

tctccccgcaa-ctggtctcaaattcacaatgatccgcctgcctcagcct

cctgagtgctgggattacaggcctgtgagatcaggccagta----GAGAG

CAGAGCTTTTT---AC--CTGGGTCCATGGGGATGGAACTGTGGCTGCTC

AAAGCTGCGGCACCCTCCTCATCTTCATCA

>Mc

CTCTACGTGCT--CTGAAATCACAGCCATAGGCTGATTAGGAAGAT--GA

CAACAATG------------------------------------------

--------------------------------------------------

---------------GGACCACT---ACTTGTCATTC-------------

--------------------------------------------------

---------------------------------------------TGTCA

TTTATTCAACGCAAAG-T-----------------------CACCAAATC

TACT----------------------------------------------

--------------------------------------------------

---------------TTGGGAAT-TGTAGACAGGCCTGGCCCACCCCCAG

G-----------------TACCAATAAC---AATTCTGAATTCTCA---t

tttttgtctttctgaaacagtttc--act--gcagttcgggctggccttg

aactcagtgtgtagcccaggctgggctcaaacaaa----------gtgat

cctcctg---cctcagcctcctgag----------catgcaccatcacac

ccaaccagc------AATTCTGAATTCTGAG-------------------

--------------------------------------------------

-----------------------------------------------TAC

TTAAAAAAAAA--TTTTGCT---ttttggtaccaggaatcagactcagg-

-aacttgtgcttgctagataggcactttagcccctgccc----ACAAAGT

ATATTTCT-----ACAAA--CAAGGCATTT------CTCTGAAACATC--

--------------------------------------------------

---CCACTA-TGGCTCAGGTC----------TGTGCACTGTATCCATGAT

TCCTGAATG---------AAAGTAGAG-----------------------

--------------------------------------------------

-----------------------------------------gtgcccccc

cccgcccccaaactggtctcaaattaataatgatccacctgcctcagcct

cctgagtgctgggattacaggcctgcaagatcaggccagaa----GAGAG

CAGAGCTTTTT---AC--CTGGGTCCATGGGGATGGAACTGTGGCTACTC

AGAGCTGTGGCGCCCTCCTCATCTTCGTCA

>Od

CTCTACATGCT--CTGAAATCACAGCCACAGGCTGATTAGGAAGAT--GA

CAACAGTG------------------------------------------

--------------------------------------------------

---------------GGACCACT---ACTTGTCATTC-------------

--------------------------------------------------

-------AATCCAAAG-T-----------------------CACCAAATC

CACC----------------------------------------------

--------------------------------------------------

---------------TTGGTAAT-TGCAGACGAGCCTGGCCC-CCCCGAA

A-------------------------------------------------

-------------gaaacagtttc--act---cagttcaggcttatcttg

aactcatgtttagccc-aaactgggctcaataacaatccttttgcctcag

cctcctgagcactgggactat-aga----------catgcaccatcacac

ccagccaac------AA--CTGAATTCTGAGGCTGGCAAAACCTTAGG-T

ACAAAG-----tgttgggttttttttccccctggtaccaggaatcgaact

cagagggctggccaaatagctcagcggattaaagcacctacaagcaggtg

caggggccaggggtttgatcccctggcctgccccccac---GGGATGGTG

CTGAGACAGCAACTGAGA---ctgggcctggtggcgtgcacctgtaatcc

cagctctggggaggctgtaaacaggcagattactaccagtccaatctagt

agtaggaccctg--AAACCCTGTAGACCCTTTCC-------TAAAAATAC

CAAAAAAAAAA----------gggatcaatctcaggaatttgtgcttggc

aggcaagcacttaagc-ccctgagctatatctcctgccc----ACTAAGT

ACTTTTCT------AAGAA-TAAAGCTTT------TCTCTGAAACATC--

--------------------------------------------------

---TCACTA-TGGCTCAGGTT----------CATGTACTGTATC-ATAAT

TCCTGAATG---------AAAAGAGAGA------ttttttgtttgtttgt

ttttg--cagtaccagggattgaactcaggaccctgcgcttgccaggctg

gtgcttactctactgagctatctccctggcccc---GGTT---tttggtc

tttttgagactggatcgccctatgcaatttaggctggccttgagctcact

ttgtagctcaggctggtcttgaactc----tgatccacctgcctcagcct

cctgactgctgggattacaggcgtgtgggatcatgccaggc----GAAAG

CAGAGCTTTTT---AC--CTGGGTCCATGGGGATGGAACTGTGGTTGCTC

AGCGCTGCGGCTCCCTCCTCATCTTCGTCA

>Cp

TTCTACGTGCT--CTGAAATCACAG------GCTGATTAAGCAT----GG

TAACAATC------------------------------------------

--------------------------------------------------

---------------GGACTTCC----------CTTG-------------

--------------------------------------------------

-TCATTCAACCCAAAG-TCCTGGGCCAGTGGAAT-------TACCAAATC

CACC----------------------------------------------

--------------------------------------------------

---------------TTGATAGTCTGGAAGACAGCCCCC----TCCCA--

----------------TAA--CAACTGCA---------------------

--------------------------------------------------

----------------ATTCTGAAGTCTG-------CAAAACGCTAATTT

ATGAAGT-------------------------------------------

--------------------------------------------------

ATTTTTCT------AAAAA-TAAGGTGTTT------CTCCGAAACTGC--

--------------------------------------------------

---CAATTACTGGCTGAGGCC----------AGTGCACTGTATC-ATGAG

TCTTGGATG---------AAAGACAGCCTTTTTTTTTTTTTT--------

--------------------------------------------------

----AAATTTTTTTTTGTCTTTTTCCTTTTTATCGGTACCGGGGATCGAA

CTTATGCCGCTGAGCTAAACACCCAGCCCCTGAAAGCACAGCTTTT----

TT------------------------------------------------

--------------AC--CTGGGTCCATGGGGATGGAACTGTGGTTGCTC

AGTGCTGCGGCTCCCTCCTCATCTTCATCC

>Dp

TTCTATGTGCT--CTGAAATCACAGCCACAGGCTGATTAGG--CAT--GG

CAACAATG------------------------------------------

--------------------------------------------------

---------------GGACTATC---CCCTGTCATTC-------------

--------------------------------------------------

-------AACCCAAAG-TCCTGGGCCGGTGAAGT-------TACCAAATC

CACC----------------------------------------------

--------------------------------------------------

---------------T-GATAATCTGTAGGAGAGCCTGCCCTCTGCCCCC

CCAAAAA---------------CGACTGC---------------------

--------------------------------------------------

----------------ATTCTGAAGTCTG-------CAAAACCCTAATTT

ATGAAG--------------------------------------------

--------------------------------------------------

-------------------------------------------------T

GGGTTTCC------CAGATCTAGCTAGTTT------CTCTGAAACT----

--------------------------------------------------

-----------GGCTGAAGCC------AGTACACTC-----TATCATGAT

TCTTGAATG---------AAAGCACAGCTCTTTT----------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGGATGGAACTGTGGCTGCTC

AGTGCTGCGGCTCCCTCCTCATCTTCGTCC

>Cop

CTCTACATGCT--CTGAAATGACAGCCACAGGCTGATTAGG--CAT--GG

CAACAATG------------------------------------------

--------------------------------------------------

---------------GGACCACC---CCATGTCATTC-------------

--------------------------------------------------

---ATTCAGCCCAAAA-TCCTGGACTAGTGGAGT-------CAGCAAATC

CACC----------------------------------------------

--------------------------------------------------

---------------TTGATAATCGGTAGGCAAGCCTGGCCCACCCCC--

-AGG--------------TAACAATATCA---------------------

--------------------------------------------------

----------------ATTCTGAAGTCTG-------CAAAACCTTAGTTT

ACGAAG--------------------------------------------

--------------------------------------------------

-------------------------------------------------C

-ACTTCTCT-----AAGAA-TAAGGTGTT------TCTCTGAAATTTC--

--------------------------------------------------

---CCACTA-TGGCTCAGGCC------AGTGCACTG-----TATCATGAT

TTC----TG---------AACGAAAGCAG-TTTT----------------

--------------------------------------------------

--------------AC--CTGGATCCATGGGGATGGAACTGTGGCTGCTC

AGTGCTGCAGCTCCCTCCTCATCTTCATCC

>Sv

CTCTACATGTT--CTGAAATCACAGCCAGAGGCTAGTTAGGG-GAT-AGA

AACAATGA---ggggctggggctgtggctcagtggtagagcacttgccta

gcacatgtgaggtactgggttcgatcctcaacaccacattaaaaaaatat

aaataaaataaa---GGTATTGGGTCTATCTGCAACTAAAGGAAAATTAT

ATTAAAAAAAAAAAAG-AAAGAAACAATGGGCCCAGCTCCTCTCCCCATT

CCTTGAATCAACCCAGAGCCCCTAACTGGTGGGGTCACTGGATCATCTTT

TTCTTTTTTTCCTCCCTCCTTTTTTTTTTTTTTTAATATTTTTTAGTTGT

CAATGGACCTTTATTTTTATTCATTTATATGTAGTGCTGAGAATCGAACC

CTTACACATGCCAGGCAAGTGCTCTAACACTGAGCCACAA-CCCCAGCTC

CAGA----------------------------------------------

--------------------------------------------------

---------------CCATCTTACTTCTAAGCAACCCTGACGGTCCCC--

-AAGTTTAGCAGAATAGCATTTCACCTGG---------------------

--------------------------------------------------

----------------ATGCTGAAGTCAG-------CAAAATCTTAGCTT

ACAAAC--------------------------------------------

--------------------------------------------------

-------------------------------------------------T

A--------------GGAA-TAAATTGTTC------CTCTGTAACTTC--

--------------------------------------------------

---CCTTTCCTGGCTCAAGCC------AGTCT------------AATTAT

TCCCTAATG---------AAAGAATGA-TCCTTTTT--------------

--------------------------------------------------

--------------AC--CTGGGTCCATGGGAATAGAGCTGTGGCTGCTC

AATGCAGTAGCTCCCTCCCCATCTTCATCC

>Oc_TDB

CTCCACGTGTT--CTGAAATCACAGGCAGAGGCCAGTCAGGGAGAAGAAA

CAACAGGA------------------------------------------

--------------------------------------------------

---------------CCAGCTCCTTCCCCAGTCC----------------

--------------------------------------------------

---TATCCGCCCAGAGCCTGTGGGCCGGTGGGA--------CCCA-----

--------------------------------------------------

---------------ATGTCAC-TTCTAGGTAAGCCTGCCCATA------

-----TAGCAGGA-AGACACTTCCCCTGG---------------------

--------------------------------------------------

----------------ATTCTGAAGTGTG-------CAGAATCTGAACT-

--------------------------------------------------

-------------------------------------------------A

TA------------AGGAAATACAGTGCT------CCGCTGTAACTTC--

--------------------------------------------------

---CCTCA-CTGGACTGGGCC------AGTCTGTTTCCTTC-ATAATGAT

TCCAGAATG---------ATAGAATGA-TCTTTTTTT-------------

--------------------------------------------------

--------------AC--CTGGATCCATGGGAATAGAGCTGTGATTGCCC

AATGCTGTGGCTCCCTCCTCCTCTTCATCC

Locus 469-5

>B3

--------------------------------------------------

---------------ggggctggagagatggctcagcggttaagagcact

ggctgctcttccagaggacccgggttcgattcccagcacccacatggcgg

ctcacaaccatctgtaactccagttccaggggatccgacgccctcttctg

gcctccgcgggcac-caggcacgca--cgtggtgcacagacatacatgc-

-aggcaaaacactcatacacataaaataaaaataaa--------------

--------------------------------------------------

--------------------------------------------

>B1F

--------------------------------------------------

--------------------ttttgtttttttgagacagggtctcactat

gtagcccaggctggcctggaactcactatgtagcccaggctggcctcgaa

ctcacggcaatcctcctgcctcagcctcccgagtgctgggat--------

--tacaggcatgagccaccacgcccggct---------------------

--------------------------------------------------

--------------------------------------------

>B1F1

--------------------------------------------------

----------------------ttttgtttttttgagacagggtctcact

atgtagcc--------ctggctggcctggaactcactatgtagcccaggc

tggcctcgaactcacggcgatcctcctgcctcagcctcccgagtgctggg

attacaggcgtgtgccaccacgcccggct---------------------

--------------------------------------------------

--------------------------------------------

>B1-dID

--------------------------------------------------

-gctgaggttttttttctcatggtcaatgctcattttattttttgggag-

--gtgtactggggatggaactcaggggcactcaaccacatcctcagccct

a---ttttgtattttatttagagacagggtctcactgagtgcttagcact

ttgcttttgcagaggctggctttgaacttgcaatcctcctgcctcagcc-

-tcccaagccactgggattacaggtgtgcaccactgcaccctgct-----

-caatatttacttttattcttaattttct---------------------

--------------------------------------------------

--------------------------------------------

>Mm

TGACTGAGGGTCGCCAGGC--CTAAAGTAGGGTCAGAAACACAAAGTAAG

GAGAAGAAAATACCAACAGAG---CATTCAGTCAAATGTG---ACCCC--

--------------------------------------------------

-----------------CTTTCTAAT---------------CCTTTACTG

GAA-----------------------------------------------

--------------------------------------------------

ACAGTTATCCAAT-------------------------------------

--------------------------------------------------

--------------GTCCATTTTGTGTCTATTTTTA--------------

--------------------------------------------------

----ACCACTGCCAGTCAC-----------AAAAGAGGCTCTGGATTACA

GATTCCAG--------------------CAACCAACCACCGTACAAGACC

CTCATCTCTCTCTT---tttttttatttttatgtatactatagctgtctt

cagagggcatcagatcccatttcagatggttgtgagccgccatgtggatg

atgggaattgaactcagaacctctggaaaagcagtcaagtgctcttaacc

actgagccgtctctccagcccc---ATCCTCATCTCTCCCGTTCTATCAA

TCCTATCTCTAT---ggggctgaagagatgactcagcagttaagagcact

tattattcatacaaagaatatgggttcagttccccgtgcccacatggcag

ctcacaatcatctgtaactccaggtctaggcgatctaaagccctcttcta

acctccataggaac-caggcatgcaaaatacagaagtacatgtaggcat-

-aggcaaaacactcaaa-----tgaatataa-------------------

-------------------------CT-ATAGTATCTTCCCTGT---TTG

AGAGAAAATAATTT------------------------------------

--------------------------------------------------

-------------------------------------AACTAT-------

--------------------------TAA------------AAG------

---GA--CCTTATGGGAAAAAAA---------------------------

--------------------------------------------------

--------------AAAATC-----------T--T---------------

--------------------------------------------------

--------------------------------------------AGTCTT

--------------------------------------------------

------AAA----CT-----------------------------------

--------------------------------------------------

----TAAGCAGTT----AAGGTAAATTAATAACACA-CCCAATGGAA---

--------------------------------------------------

--------------------------------------ACATT--TA---

----TAGTCAGAGCA-TAAGTTTTT-------------------------

--------------------------------------------------

-------------GGAC----AAGACAACAAAAGACAATACCAGGAGGCA

TTACAC-------A------------------------------------

--------------------------------------------------

TTTGT----------AGTCTTCTTGAGCCTT--A-ACTCA----------

CATCAC--CCAG----ATCCAC----------AA--AGG-ATGCTGCTCT

--GGTGCATGAGATG---A--ACCATGCGTGAG-TCATTATA---AAAAC

AAAGATCCTGAAT----ACCAGTG-GCTG-CTGGAGAGCCA--CTTCAA-

--CAGC------CAGGCCTCAC--CTCTGAAATTTGCAATCAGA

>Rn

TGATTGAGGGTCACCAGGC--CTAAAGTAGGGTCAGAAACACAAAGGAGA

AGAAAA--CACTCAACAGAGCTCTAATTCAGTAAAATGTGACCCCCCCCC

--------------------------------------------------

-----------------CTTTCTTAT---------------CCTTTACTG

GAA-----------------------------------------------

--------------------------------------------------

ATTGTTATCCAAT-------------------------------------

--------------------------------------------------

--------------GTCCATTCTTTGTCTACTTT-C--------------

--------------------------------------------------

----------------------------------------------ACCA

CT--GTCAGTCACAGCAGAGCCCC--TGGATTAGAGATTCCA-GTGAC-C

AGCCATTG--------------------TCCAAGA-----TCCT------

--------------------------------------------------

-------------------------CATCTCTTATGCTTCTAT---CAAA

TCCTATCCCTGT---ggttccgaagagatgacttagcagttaataacact

tattctt------acaaatatgggttcaactccctagacccacatggtag

ctcactaccacctgtaactctagatcta---------aagtcctcctcta

acctccacaggaac-taggcatgca-----ca-tagtacgtatatacatg

caggcaaaaca-tccaa-----tgaataaaa-------------------

-------------------------CT-ATAGTATTTTTCCTGT---TTG

AGAGGAGAGAATTT------------------------------------

--------------------------------------------------

--ATGCTATTAA-----AAACTGTATA-----CAG-----ttttttagct

cagtggtagagcgcttgcctagcaagcacaaggccctgggttcggtcctc

agctccaaaaaaaaaaaaaaaaaaaaaacaaacaaaaacaaccccccaaa

aaa-----------------------------------------------

--------------------------------------------------

-------------------------------------CTGTATAC-----

----------------AT-CTTCCCCTAA------------AAA------

---GGGCCTTTATGGGAGAAAAACAACAACAAAAACC-------------

--------------------------------------------------

--------------AAAACA-----------C--T---------------

--------------------------------------------------

--------------------------------------------AGTCTT

--------------------------------------------------

------AAA----CA-----------------------------------

--------------------------------------------------

----TAAGCAGTT----AAGATAAATTAATATTCTA-CTCAATGGAA---

--------------------------------------------------

--------------------------------------ACATT--TA---

----TAGCCAGAGTGTTAAGTTTTT-------------------------

--------------------------------------------------

-------------GAAC----AAGACAACAAAAGACAACACCAG------

--------------------------------------------------

----------------GTCTTCTTGAGTCTT--A-ACTCA----------

CACCAC--CTAGATACATCCAC----------AA--ATG-ATGCTGCTCT

--GGTGTATGAGATG---A--ACCACGCATGAG-TCAGTATA---GGAAG

AAAGATCCTGAAT----ACCAGTGAGCTG-CAGGAGAGCCA--CTTCAA-

--CAAC------CAGGCCTCAC--CTCTGAAATTTGCAATCAGA

>Mu

TGACTGAGGGTCACCAGGC--CTAAAGTAGGTTCAGACACAAAAAGGAGA

AAA-----TACTCAAGAGAG------------------------------

--------------------------------------------------

----------------CCATTCTGTGTCTATATT-C--------------

--------------------------------------------------

----------------------------------------------ACCA

CT--GCCAGTCACAGCATAGGCCC--TGAGTTAGAGGTT-----------

----CCAA--------------------TGACCAACCATTGTACAAGA-C

CTCACCTCTTATGT------------------------------------

--------------------------------------------------

-------------------------------------T-TTAT---CAAA

TCCTATCTCTAT---gaggctggagaaatggctcaggagttaatagtact

tattgttcttgcaaagattatgggttcaattcccagtgcctgcatggcag

cttacaaccacctgtaactccagttctaggggatctaaagccctcttcta

acctccacaggcac-caggcatgca-----ca-ctgcacagacatacata

tagacaaaac--tcaaaattaaaaataaaaaaa--------AA-------

----------------------------ATTGTATCTTGACAGT---ATG

CAAGA---------------------------------------------

--------------------------------------------------

--------------------CT----------------------------

--------------------------------------------------

-----------------------TA-----------CCTGCATCC-----

----------------AT-GTCCTCATAC------------GAG------

-------CCTTATGGTAA------------------T-------------

--------------------------------------------------

--------------AAAACC-----------C--T---------------

--------------------------------------------------

--------------------------------------------AGCCTT

--------------------------------------------------

------AA------C-----------------------------------

--------------------------------------------------

----AAAGCAGTG----AAGATA----AATATTGTA-CCCAATGGAA---

--------------------------------------------------

--------------------------------------ACATT--TA---

----TAGCCAGAGTG-TAAGTTTCT-------------------------

--------------------------------------------------

-------------GGAT----AAGACAATAAGTGGC-------------T

CTCCAC-------A------------------------------------

--------------------------------------------------

TCTGC----------AGTCCT-------CTT--A-GCTCA----------

CACCAC--CCAGCCGTAATCAC----------AA--G-G-ATTCTGCTCT

--GGTACATGAGATG---A--ACCA----TGAG-TCAGTATG---GAAAG

AAGGATCCTGAAC----ACCAGTGGGCTG-CC-AAGAGTCA--TGCTGA-

--CAGC------CAGACCTCAC--CTCTGAAATTTGCAATCGGA

>Cc

TGACTGAGGGTCACCAGGC--CTAAAGAAGGGTTGGAAACACAAGGAAAG

GAGAAAATTACTCAAGAAAGTT--CTTG-AGTG--------CCCCC----

--------------------------------------------------

-----------------TTTTCTAAC---------------CCTTCACTG

GAA-----------------------------------------------

--------------------------------------------------

ATGATCCTCTACT-------------------------------------

--------------------------------------------------

--------------AT----------------------------------

--------------------------------------------------

------CAGCCACAGTTGAGGCCC--TAGGTTAAAAGT------GACCAA

CCACCATACCAGACCCT---------------------------------

--------------------------------------------------

-------------------------CACCTCTCATGTT-TTGT---CAAA

TCCTACCTCCAT---g-ggctagagagatgggtaagcagttaagaatact

tactgttcttgcaaaggacctgggttcaattttcaacacccaaatggcag

ctcacaactgcccctaacttcagatctaagggatctaaaacgctcttcta

atctccacagccactaaagcacata-----ca-cagtatagacatacatg

cagaaaaaaaaaaaaaccaatctagaatagaacaaaaattcTA-------

-------------------------CC---TTTATCTTCTCTAT-----T

TGAGAAGGGAATTTTTT---------------------------------

--------------------------------------------------

--------------------ATGCACATAGAAATCTAGAGAAAC------

--------------------------------------------------

-----------------------AA-----------ACTATATCC-----

----------------AC-TTCCCCCTAA------------AAA------

---GGG--CATATGGAAAT-------------------------------

--------------------------------------------------

--------------AAAACC-----------CATT---------------

--------------------------------------------------

--------------------------------------------GGTCTT

--------------------------------------------------

------AACAAATCT-----------------------------------

--------------------------------------------------

----TAAGCAGTAAACTAACATGAATTAATATTGTA-CCCAATAGAA---

--------------------------------------------------

--------------------------------------AC------A---

----TAGCCAGAGTG-TAAGCTTTT-------------------------

--------------------------------------------------

-------------GGAC----AAGACAGCAGGAGGC-------------T

CTACTA-------G------------------------------------

--------------------------------------------------

TTTCTTCTAGTCAAGACTC------AAGTTTAAA-ATTCA----------

CACCAC--CCAGCCACATCCAC----------TA-------------TCT

--AGT----GAGATG---A--ACCA----C-AG-CCAGTAAG---GGAAG

GAGAATCCTGAAG----ATCAGTGGGCTG-CTAGGGAGCCA--TTCCAAC

AGCAGC------CAGGCCTTAC--CTCTGAAATTTGCAATCCGA

>Oz

CGACTGAGGGTCGCCAGGC--CTAATGTAGGATTGGAAACACAAAGAAAG

GAG--------AAAATAAGAAAG-CTCTAATTCAGTTAAGTGACCTCCAC

CCCCCCCC------------------------------------------

--------------------------------------------------

-----------------TTTTCTATC---------------CCTTTATTG

GAA-----------------------------------------------

--------------------------------------------------

ATGGCTCTCCAAT-------------------------------------

--------------------------------------------------

--------------ATCCATTCTGTT---------C--------------

--------------------------------------------------

----------------------------------------------ATCA

CT--TCCAGCCACAGTAGAGTCCC--TGGGTTAGAACT-------GACCC

A-CCACAC--------------------CAGACCCT--------------

--------------------------------------------------

-------------------------CACCTCTCATGTT-TTAT---CAAA

TCCTACTTCTAA---ggggctggagagatgattgagcagttaagagcatt

tactgttcttaaaaagaacctgggttcaattcccagcaaccacatgacag

ctctcaactacccatcacttcagatctaggg-atctaaaaccctcttcta

atttctgcaggcactaaggtgcaca-----ca-cagtatagacatacatg

caggagaaaaa-tcaaaaaagaccaaaaaaaaaattc----TA-------

-------------------------CT---TCCATCTTTCTCGT---TTA

AGAGAAAAGAATTT------------------------------------

--------------------------------------------------

--------------------ATGCA-----AGATTTAGAGAAACTACATG

TACACCTCCCCTAAAAAGGATCATATGGAAATGAAACCCCTTTAAGAGAA

GGGAATTTATGCAAGATTTAGAGAA-----------ACTACATGT-----

----------------ACACCTCCCCTAA------------AAA------

---GGA-TCATATGGAAATGAAACCCCTTTAAGGTATTTTTTTTGGGGGG

GGG-----ttgtttgttttttcaaaactaggtttctctgtgtagctttgg

aacctatcctggaactcactttgtagatcagg-------ctcacagagat

ccacctgcttctgcctccctagtgctgggattaaactcatgcgccaccgc

cgcccagct-----AAAACC-----------CCTT---------------

--------------------------------------------------

--------------------------------------------AGTCTT

--------------------------------------------------

------AACAAATCT-----------------------------------

--------------------------------------------------

----TAAGCAGTG----AACGTGAATTAATATTGCA-CCCAATGGAA---

--------------------------------------------------

--------------------------------------ACATT--TA---

----TAGCCAGAGTG-TAAGTTTCT-------------------------

--------------------------------------------------

-------------GGAC----AA-----TAGAAGGC-------------T

CTACAC-------G------------------------------------

--------------------------------------------------

TTTCT----------AGTC------AAGTTTAAA-ACACC----------

TGCCAC--CCAACCACATCCAC----------AGAAAGG-ATGCCGCTCT

--AGTACACGAGATG---A--ACCA----CAAG-CCAGTAGG---GGAAG

GAGGATCCTGAAG----ACCAGTGGGCTG-CAAGGGAGCCAACTTCCAAC

AGCAGC------TAGGCCTCAC--CTCTGAAATTTGCAATCGGA

>Se

TGACTGAGGGTCGCCAGGC--CTAAGGTAGAGTG---AACAGAAAA---G

GAG--AAAAACTGAAGGAGGGAG-CTTTAACTATGAGGAA---CTCACAG

TCTG----------------------------------------------

--------------------------------------------------

-------------------------------------------------A

AGAGTTAGTGCAGTATGACTTCTAAC---------------CTCTTACTG

GGA-----------------------------------------------

--------------------------------------------------

AAACCAGGGC----------------------------------------

--------------------------------------------------

------CAGCCACAGCAGATCCTGCCTGGGCAAGGGGCTCCAGTGA---C

CAATTACTGTGAGGGGCATGTGCCTCTCATATT-----------------

--------------------------------------------------

-------------------------CACCCACTCTCGTTTCAT-------

--------------------------------------------------

---------------------TAAATACTCTCTCTCTTCCCAGT---CTG

ACAGAAGGGAAGTT------------------------------------

--------------------------------------------------

--------------------ATGCA-------------------------

--------------------------------------------------

-----------------------AG-----------ACTAGAGGA-----

----------------AACTGCTCCCCAA------------AAGCCTCAT

TATAGAACTTTATGGAAATGAAACTGGT----------------------

--------------------------------------------------

--------------CAAGTC-----------CTTA---------------

--------------------------------------------------

--------------------------------------------GGTGTT

T-------------------------------------------------

----TGACCAAATCG-----------------------------------

--------------------------------------------------

----TAAGCAGTG-----AGGTCAATGAATACTGAACCCCAGTAAGA---

--------------------------------------------------

--------------------------------------ACATTTATA---

----TAGGCAGAATG-CAAATTTCTATC----------------------

--------------------------------------------------

------------GAGGC----AAAACAG--GAGGGC-------------T

CCATAC------TA------------------------------------

--------------------------------------------------

CTTCC--------------------AATCTT--A-ACTCG----------

GACCACCTCTGGCTACATCCAC----------AA----A-ACATATCCCT

--GGT---------------------------------------------

----GTCCTGAAC----ACCAGTGGGTTG-CCAGGGAGCCA--CTACAA-

--CATC------CGACCCTCAC--CTCTGGAGCTTGCAATCGGA

>Jj

TGACTGCGGGTCACCAGGC--CTAAAGTAGAGTGGGGGTGAAAAGA----

-------------AAACAAGAAG-CTTTAACTGTAAGGAA---TTTTTAG

TCC-----------------------------------------------

--------------------------------------------------

-------------------------------------------AAGAACT

CAAGTTAGCAAGTCACCACTTTAAAC---------------ACGTACAGG

GTA-----------------------------------------------

--------------------------------------------------

CAGTCCCACTGTA-------------------------------------

--------------------------------------------------

--------------TCT---------------------------------

--------------------------------------------------

---------TCAGCTCAGT-GCCC-AGTTCAGGCAAGGATTAAATT----

--------------------------------------------------

-------------------------CCTGGTTTTCATTGCTCATATC---

--------------------------------------------------

---CTCCTACTTCTGTTTCATTAAATCCTATC-ATCT-CCCTAC-TTTGA

AGAAAAGGGAAGTT------------------------------------

--------------------------------------------------

-------------------TTTGGA-------------------------

--------------------------------------------------

-----------------------AG-----------ACTAGAGAAA----

-TGCAAAAAAAAAAAAAAA--------AAAAACACAAAAAAAAAACCTCT

---------------TTGTAAAAGCCT---TATGGATTTGAAACT-GGT-

--------------------------------------------------

--------------CAAATT-CTGTATATTGTTGA---------------

--------------------------------------------------

--------------------------------------------TTCTGC

T-------------------------------------------------

----TAAATGAATTT-----------------------------------

--------------------------------------------------

----TAAGCAGCAAAAGGTGGTGAATTA--ATAGAGCCCCGGAACA----

--------------------------------------------------

--------------------------------------AAAGT--TA---

----TAACCAGAATA-TAAGTTTCTGGTC---------------------

--------------------------------------------------

------------AAGAC---AAATATAAAAGGAGGG-------------C

T--TAAATAGACTG------------------------------------

--------------------------------------------------

TTTTT----------AATCCTTCAAAAGTCT--ACCACCACCGCCACCGC

CACCGCCACAGGACACAGCCAC----------AGAAAGG-ATTTTTCTCT

TA--TGCACTAGATG---A--ACTA----CAAG-CTGGTATGCTAATAG-

---CGTCCTATAA---AACCA-TGGACTACCCAGCCAGCCA--CTAG---

ATCAGC----------TCTCAC--CTCTGGAACTTGCAATCAGA

>Asp

TGACTGGGGGTCACCAGGC--CTAAAGAAGGGTGAGGGACACAGAA----

GGGGAAAAAAATCAAGAAGGAAG-TTTTGACCCTGAGGGA---TTTATAC

ACAC----------------------------------------------

--------------------------------------------------

------------------------------ATTTTTTAAGAGTTCGGTC-

--ATTGTGTCA--CCATCTCTCTAAC---------------CCCTTACTG

GGC-----------------------------------------------

--------------------------------------------------

AGGGTATCCAAAG-------------------------------------

--------------------------------------------------

----CCCCATCAGAGCTGCAGTTCAGGGCCAAGTTC--------------

--------------------------------------------------

-----------------------------------------TAGATCCAG

TATTGCCAGTGTCTGCCACAGCTG--AGA---CCCTGGGCTAAGAGTACT

GAGGACCG--------------ACCAAGTACCAGG---------------

--------------------------------------------------

-------------------------CCCCCGCTAGCCATAACAGCATGG-

--------------------------------------------------

-------------------------GTCCTCCTGTCCTCCCAGT---TTG

AGGAAAGGGAAATCT-----------------------------------

--------------------------------------------------

--------------------AGGCA-------------------------

--------------------------------------------------

-----------------------AGTGCCCTACACCACTGAGCCAC----

-ATGCCCTCAGCCCCCAAATTTTTTTGGA----AGAA-AGAAAAATCTAT

ACGAGACTGGAGCAGCAGTCAGAGCTT----TCAGACGTGTGACT-GGT-

--------------------------------------------------

--------------CAAACT-CAGTCAACTGCTTA---------------

--------------------------------------------------

--------------------------------------------GTCTTC

T-------------------------------------------------

----TGAACAAAGTTTTTGGGTTTTTTTGGGGGGGGTTC-----tttttt

tttttggatttttttgagacagggtctcactgcatagcccaggctg---t

cctggaactatgtagaccaggctggcctcgaactcgcgctgatcctcctg

tctcagcctcccaagtgctgggattacaggcatgcgccacgcctggcac-

----CTCTTGAACAAATCTTCAGCAGCAAAAGGTAATGAATTAATACTGA

GCCCCAGTG-----------------------------------------

--------------------------------------------------

---------------------------------AAA--ACATT--TA---

----TAATCAGGATG-GAAGCTTCT-------------------------

--------------------------------------------------

------------AGGACAG-ACAGACAATAATGGGG-------------T

TTCTGGACAGGCTA------------------------------------

--------------------------------------------------

TTTCT----------AATCCT--GGACTCCT--A-ACTCA----------

CACTACCATAGACCACATGCAC----------AGAAAGG-AGGCATCTCT

TGGGTGCATGAGATG---A--ACCA----CCAAGTCAAGGTGCCAAAAA-

AGCTGTCCTGTAC----ACCA-CAGGCTG-CCAAGAAGCCA--GCTAGAT

GGCTGC------C---CCTCAC--CTCTGGAACTTGCAATCAGA

>Cgu

TGACTGGGGGTCACCAGGC--CTGAAGTGAGAAGACAGAAAAAGGG----

----------CTCATCAAGAAAG-CAGTGACCTTAAGAAA---TTTACAG

TTTTAAAAAT-----tcagtcagcctttgagttaaaatcaagtgtagtat

aggttaccagtttaacatctgatgacaagatcttaaatgcatttttggag

ctgggagacaaaagaagcttgctgttcactccacgcatcaacctggtatt

gcagtacctccaggaatg--------------------------------

-------------------------------------------------A

GCCCCCGACCCCCGGAAGAAATTACTTGGTGGTGAAAAAAAATTCAACC-

--ATAAA-TCATTATTTCTTTCTAAC---------------CCCGTTCTA

GAC-----------------------------------------------

--------------------------------------------------

ATGGCT--------------------------------------------

--------------------------------------------------

---------------TAGTCTCAAGGTATTCAGCTC--------------

--------------------------------------------------

-----AGTACCTGGCTCTGCAATTGGAAT------------CACCAGTGT

CT--CCCACACATAGCAAAAGTCC--TGAGTTAAAAT-CACCAGCCTCTA

AGCACCAG-------------------------AT---------------

--------------------------------------------------

-------------------------ATTCACCAGGCAC-AAAATTCACA-

--------------------------------------------------

-------------------------AAATCCTAATCTTCCCAGT---TTG

GGGGAAGGGACATTT----------tgttttgttcggaaacatcttgctc

tgcacaccaggctagtctgaattcacaatgtaacccaggctggcctcaaa

ctcagagcaatcctcctatttcagcctcccagagtactgagt----agga

tttacaggcatgtgccaccacgcatg------------------------

--------------------------------------------------

------TGGCTAATTTCT--ATGTA-------------------------

--------------------------------------------------

-----------------------AT-----------GCTGGGGGAC----

-CATACTCAG------GGGTCTTGCCCAA---------------------

-------------GACAGGCAGTGCT----------CTAACTACTGAGC-

--------------------------------------------------

--------------TATGT---------ATGCTCC---------------

--------------------------------------------------

--------------------------------------------CAGCTC

T-------------------------------------------------

----TAAGCAAATCT-----------------------------------

--------------------------------------------------

----TAGGCAACAAAGGTTATGAATTG-----------------------

--------------------------------------------------

--------------------------------------ACAT--------

----TAACTGGGATG-GATGTTTCCAATTCTCCT----------------

--------------------------------------------------

GGGCTTTTT---CAAAACC-AAAAATAGTAAGCAAT-------------A

TTCTGTAGAGAATG-----tttttaatcttccgaaattttttttcctctt

tgtagaagggattgagccaagggccttc----------acatccccagcc

aagtttttggttctaattttaaggcacagtctcattaggtttgagcccag

cctgagaaacttagt---------aac-ttgtg--atcctgccacagcc-

-tcccagagtactgggatcacaggcgtgtaccaccaaatccagct-----

-TCC------------------CTAAACTTT--A-GATCA----------

CAT---TA----TCACCTTCAC------------AAAAGAATGCTTCTCT

TAACTGCGTGAAATTAACA--AATG----TCAA-TGAATGCACTAAAAAG

AACCGCCTAGTAC----ATCA-CAGGCTA-CCAGAGCA------------

ATCAGC----TTT---CCTCAC--CTTTGGAACTTGCAATCAGA

>La

TGACTGGGGGTCACCAGGC--CTGAAGTAAGGTGAG-GACAGAGAG----

----AAAAGGCTCACTAAGTAAG-TACTGACCTTAAGGAA---TTTACTT

TTTT-----tgaggcaaggtcttgttctgtagtagagaactggccctgaa

ctgtgtagcccaggctggcctgaactcaaggcaattctctgacctcacct

cagcctcccaagtgctggtattatagacctgtgacaccacacccagctag

t---ATGT---ggtgctaaggaattgaacccaaggccttgtgcttgctgc

taggcaagcgcttcaacaagagtcatttctccagcccc------------

-------------CAAGGAATTTAC------ACTTTTAAGAATTCAGCC-

--ATAAG-TCATTATTTCCTTCTAAT---------------CCCTTTCTA

GAT-----------------------------------------------

--------------------------------------------------

ATGGCT-AAAATA-------------------------------------

--------------------------------------------------

--------------GTATCATAACATCT-GCAGTTC--------------

--------------------------------------------------

-----AAAGCTCAGTTATACATTTGAAAT------------CATTAGTGT

TT--GCCACACATAGCAGAGGCAC--TGGATTAAAAAGCCTTGGTGACTC

CGTACCAG--------------------CTACAAA---------------

--------------------------------------------------

-------------------------GTTCTCCCACTACTTAAGTTTCTT-

--------------------------------------------------

-------------------------CAAACCCTACCTTCCCAGT------

--------------------------------ttgagtgaaatcttgctc

tgtagtccaggctggtcctaa---actatgtagcccaggctggcctcaaa

ctcacagcaaacgtcctgccttagcctcc-ggtctgctgagattacagga

--atgtgccatgatgctcggctaa----------tttttttgaagtaagg

tctcgctctgtatttcaggctggtcccatactttaggggcaatcctcctg

cctcagcctcctaaatgctgggattacaggaatgcatcaccactctcagc

---tagtatgtggtactgg---ggaatcgaactcaaggctttgtgcttgc

tgggcaagcactctaaccactgtgctattt---ttcttccagcccc----

------TGGCTAATTTTT--ATGTG-------------------------

--------------------------------------------------

-----------------------G------------ACTGGGGAA-----

--------------------------TAA---------------------

-------------GAT------TGTT----------CTA-----------

--------------------------------------------------

----TAGA------------------------------------------

--------------------------------------------------

--------------G-GATATTTCTAATCTTCCC----------------

--------------------------------------------------

----------------------------TAAGC-----------------

-------------C-----tttttcttctctcattttttttct-------

--gtggtggcatagagcccaggaccttcacactgaactacatccccagct

aattttttggttttgattttgagacattgtctcactaagtcactaagctg

tgtgggtagggttca---------aactagcaatcctcctgcctcagcc-

-tccca--gtgttgggattattggtctgtaccattgg-----gct-----

-TCC------------------CTAAACTTT--A-AAACA----------

CAT---CACAGGCCGCAGCCAT----------TAAAAAGAGTATTTCTCT

CAGGTGTGTGAAATTAACA--AATA----CAAA-TCAATGTACTAAAAAG

GACTGTCCAGTAC----ATCC-TGGATTA-CCAGAACA------------

GCCAGC------T---CCTCAC--CTTTGGAACTTGCAATCTGA

>Ts

TGACTGGGGGTCGCCAGGC--CTGAAATAAGGT-AGAGACACAAAGATGG

GG-AAAAAAACTCGAGGAAG----CTTTGACCTTGAAGAA---TTTAAGA

GTTC----------------------------------------------

--------------------------------------------------

---------------------------------------------ACCC-

--ATTAGATTATTTATTCCT---AAT---------------CCTTTAACA

CAC-----ttttttttgagacagggtctcactttgtagttcaggctggcc

ctcagctcactatgtagagcccaggaaagcctcgaactcagcaatcctcc

tgtctctgcctgagagctgggatgacaggagtgagccaccacgcccggc-

--CCTGTGGTATGTGGTATT---gattactggtgggtgtgagccaccacg

tccagcattgtatgtggttactgggatcaaactcaggaccttgcgcttgt

gaggcaggtgccagaaccactgagctaaattttcggccc---TAACACAT

GTAATTTTAAGCA-------------------------------------

--------------------------------------------------

--------------GCTTTATCAGGTCTTGAATTTTTTTCCCCC-----t

ttggagacatgatctcactatgtatttcagactagccttcaactgtgttg

cccaggctagccacaaactgggatcacagacatgtaccaccatacttggc

-----AAGGTTTTAAATTTTAGAAAGCAGCTCTGCTTTTTGGATGATCAG

TGCTGCCACAGCACAGG----TAC--TAGG-TTAAAAACCCT-GGTGAGA

GC-ATTGGGTTCTCACCAACCTCAAAAAACAAAG----------------

--------------------------------------------------

-------------------------GTTTTTCTCACCTCTCAAGTTTCA-

--------------------------------------------------

------------------------TCAAATTCTATCTTCCCAGT---TTG

AGGGAAGGGAAATCT-----------------------------------

--------------------------------------------------

--------------------ATGCA-------------------------

--------------------------------------------------

-----------------------AG-----------ACTGGATCAA----

-CTGCCAGAA------AAAC------TGATTTTAGAGTAGGAAAAT----

----------GATGGTATTAAGGGCT--------------------GAT-

--------------------------------------------------

--------------CAAATTGCAGT---CTGCTTA---------------

--------------------------------------------------

--------------------------------------------GTCTTC

T-------------------------------------------------

----TGAACAAATCT-----------------------------------

--------------------------------------------------

----TAAGCAACGAAG--------------AAAGAGCCCCAGTAAAGGGG

CTCAAGTAC-----------------------------------------

--------------------------------------------------

---------------------------------AAATTACATT--TATAC

AGATTAAACAGGACA-GGAGCTTC--GTTTCCCT-----gttttcaatta

gcaataatcacacctctgaaaaacttcaatggc---tacagtact-----

ACCACTATGCAAAGCTTC--AAAGAGAAATA-CATT-------------T

TTCTGTATAACATG------------------------------------

--------------------------------------------------

TTTCT----------AAATCTTCTAAGCTTT--A-AAACA----------

CACCATCATAGGCCACATTCAC----------AAAAGA--ATGCTTCCTC

TGGATGCATGATGTT---A--AATA----CAAA-TTCGTGTGTT--AAA-

AGTTGTCCTATAC----ATCA-TGGCCTA-CCAGAGAACCA--CC-----

ACCAAC------C---TCTCAC--CTCTGGAATTTGCAATCTGA

>Pcu

TGACTGGGGGTCACCAGGT--CTGAAATGAAGTGGAGACACAAAAAACAA

TTGGAGGGAATCTC--AAGGAAG-CTTTGACCTCAAAG-A---TTTACAG

TTTT----------------------------------------------

--------------------------------------------------

-------------------------------------AAGAATTCAACC-

--ATTAGGTCATTACTTCTTCCCAAT---------------CTTTTACTA

GAT-----------------------------------------------

--------------------------------------------------

ATGGTTTTATTAA-----ttttggtacagtgaacccaattcaggacctca

tgcttgccaggcaggtgcttggaacactaagctacatccctggtcc----

-TTAGACATGGTTTAAACAGTCTCATCAAGTCTCCCCCTGCCCCG---tt

tttttttggtctttttcagacagggtctcactatgcagttcaggctggtc

ttgagctcacttttgtagcccaggctggtctcgaactcgcaccaatctgc

ctgccttagccttccaagtgctgggattacaggcgtgcgtcaccacgccc

agct------------------AGGTCTTCC-TTTT--------------

--------------------------------------------------

-----AGAAAGCACTTCTGGTTTGAGGAT------------TAGCAGGTA

AC--ACCAGAGCACAGA----ACC--TGACTTTAAAA--CTCTGGAGACA

GC-ACCAGGTCCTCATCAAACACAAAGAT---------------------

--------------------------------------------------

-------------------------CACAGGTCTTCCTTTCAACTTTTA-

--------------------------------------------------

------------------------TAT----CTATCTTCCCAGT---TTG

AATGAAGGGAAATCT-----------------------------------

--------------------------------------------------

--------------------ATGCA-------------------------

--------------------------------------------------

-----------------------AG-----------GCTCCAACAA----

-CCAACAGAA------AAACTCTCTTTGACTGCAGAATAGGAAAAT----

----------GGTGGCAATAAGTGCTG--------ATTTCCAACT-GGT-

--------------------------------------------------

--------------CAAACTCCAAT---CTGCTTA-----ttcttctttt

ttttttgtgggaccagggttcaaactcacgaccttgcacttac-----ca

agcaggcacttgtgccacagag-ctatctccccagcccc-----TGT---

--------------------------------------------------

-------AA----------ttctctcttatttttgagacagttatcttgc

cacgcaggt-------caggctggtctt----------------------

------aaagctcacactgatcctgctccctcagcctcctcagagctggg

actacaagtgtgtacaagcacacctggct-----AG--ATATT--TA---

----TAACCAGGAT--CAAGTTTCCCGTTTTCT-----------------

--------------------------------------------------

------------TGGACTCAAAAGACTAACAGAGGT-------------T

TTCTATACAACATG------------------------------------

--------------------------------------------------

TTTCT----------AATCCTTCTAACCAT-----AATCA----------

------CACAGGCCACAACTAC----------AAAAGCA-ATGTTTTACT

CGG----ATGATGTT---A--AATA----CACA-TTAAT--ATT--AAG-

ATGCATCGTGTATAACAATCA-TGGACTA-ACAGGAAATTG--CC-----

ACTGGC------C---CCTCAC--CTCTGGAATTTGCAATCTGA

>Cp-TDB

TGACTGGGGGTCACCAGGC--CTGAAATGAGGT-GGGTAGAGATG----G

GG--AAAAAGCTCAAGGAGGAAG-CTTTGACCTTGAAGAA---TTGACAA

TTTT----------------------------------------------

--------------------------------------------------

-------------------------------------AAGCTATT-----

--ATTAGGTCAGCATTTCTTCCCAAT---------------CCT-CACTA

GAC-----------------------------------------------

--------------------------------------------------

ATGGTTTTAAACA-------------------------------------

--------------------------------------------------

--------------GGCCCATTAGGTCTTCCACTTT--------------

--------------------------------------------------

-----AGAGAGCACTTCTGGTTTTGGCAC---------------------

--------------------------------------------------

-----TAGGTCCTCCTCAACCACGAAGAGTGTG-A---------------

--------------------------------------------------

-------------------------GTCCTCTCATCTCTCA-------C-

--------------------------------------------------

-------------------------CAAACTGCATCCTCCCAGC---TTA

AGGGAAGGGAAATCT-----------------------------------

--------------------------------------------------

--------------------ATGCT-------------------------

--------------------------------------------------

-----------------------AG-----------ACTGGAGCAA----

-CTGCGAGGA------AAACACTTTTTAACCCCA-AGTAGGAAAAT----

----------GATGGCACTGAGAACTG-------ATTTTGCAACTGGGT-

--------------------------------------------------

--------------CAGATTTCGTC---TCGTTTA---------------

--------------------------------------------------

--------------------------------------------GTCTTT

C-------------------------------------------------

----TGAACTAATCT-----------------------------------

--------------------------------------------------

----CA---CAGAAGA--------------CTGGAGCCTCAGTGCAG---

-------AC-----tttttttttttgatctcttttgagaca-ggttttgc

tctgcatttcgctatacaggtgggac-tga-ctcactttgtagcctcgcc

agcct-caaa-ttgtagcaatcctcctgcct------cccaagggccagg

actacaagtgtgtgacatcacacctggct-----AG--ACGTT--TA---

----TAACCAGGATG-GAAGCTTCCTGTTTTCT-----------------

--------------------------------------------------

------------AGGACTC-GAGGACAAATA--GCT-------------T

TT-TGT---ACATA------------------------------------

--------------------------------------------------

TTTCT----------AATCCTTCTAAGCTTT--A-AACCA----------

CGTGA-CACAGGACACATCCAC----------AAAAGTA-ATGC------

-------------TT---A--AATA----TCAA-TTAGTGCATT--AAA-

AGCTGTCCTGTAC----ATCA-TGGGCCA-CCAGCAAGTCA--CC-----

ACCAGA------C---CCTCAC--CTCTGGAACTTGCAATCTGA

>Dp

TGACTGGGGGTCACCGGGC--CTGACATGAGGT-GGAGACAAAGAGATGG

GG--AAAAAGCTCAAGGAGGAGG-CTTTGACCCTAAAGAA---TTTGCAG

TTTT----------------------------------------------

--------------------------------------------------

-------------------------------------AAGAATTCAGCCA

CTATTAGGTCATTACTTCTTCCCAAT---------------CCTTTACTA

GAC-----------------------------------------------

--------------------------------------------------

ATGGTTTTAAGCA-------------------------------------

--------------------------------------------------

--------------GGCTCATCAGCTCTTCCACTTT--------------

--------------------------------------------------

-----AGAGAGCACTTCTGGTTTTGGGAT------------CATCGGTGT

TG--GCCAGAGCGCAGG----TCC--TAGG-TTAAAA-TCCT-GGTGACA

GC-ACCAGGCCCTCCTCAACCACGAAGAGCACG-----------------

--------------------------------------------------

-------------------------AGTCCTCTCGTGTCTCAGCTTTCA-

--------------------------------------------------

------------------------TCAAATTTCATCTTCCCAGC---TTA

AGGGAAGGAAAATCT-----------------------------------

--------------------------------------------------

--------------------ATGCA-------------------------

--------------------------------------------------

-----------------------AG-----------ACTGGAGCAA----

-CTGCCAGAA------AGACGCTCTTCAACCC---AGCAGGCAAAC----

----------AATGGCACTGAGAACTGTGGAACTGATTTGCAACT-GGT-

--------------------------------------------------

--------------CAAATTTTGGT---CTGTTTA---------------

--------------------------------------------------

--------------------------------------------GTCTTT

C-------------------------------------------------

----TGAACTAATCT-----------------------------------

--------------------------------------------------

----T----TAGGAGG--------------ATTGAGCCCCACTGCAG---

-------AC-----tttgggggggggggtctttttgagatagggttttac

tatgcaatttgctacacaggctggcactgaactcactttgtagcctacgc

tggcctcaaaattatggcaacccttctgcctcagcttcccaagtgctagg

actacaagtgtgtgccaccacacctggct-----AG--ACATT--TG---

----TAACCAGGATG-GAAGCTTCCTGTTTTCC-----------------

--------------------------------------------------

------------AGGACTC-AAGGACAAATAAGGGG-------------T

TT-TGT---ACGTG------------------------------------

--------------------------------------------------

TTTAT----------AATCCTTCTAAGCTTT--A-AACCA----------

CGCCA-CATAGGACACAACCAC----------AAAACTA-ATGC------

-------------TT---A--AATA----TCAA-TTAATGCACT--AAA-

AACTGTTTTGTAC----ATCA-TGGG-CA-ACAGCAAGTCA--CC-----

ACCAGC------C---TCTCAC--CTCTGGAACTTGCAATCTGA

>Cop

TGACTGGGGATCACCAGGT--CTGAAATGAGGT-GGAGACACAGAGATGG

GGGAAAAAAGCTCAAAAAGAAAG-CTTTGACCCTGAAGAA---TTTACCA

TTTT----------------------------------------------

--------------------------------------------------

-------------------------------------AAGAAATCAGGC-

--ATTAGATCA---TTTCTTTCCAAT---------------CCTTCACTA

GAC-----------------------------------------------

--------------------------------------------------

ATGGTTTTAAACA-------------------------------------

--------------------------------------------------

--------------CTCTCATCAGGTCTTCCATTTT--------------

--------------------------------------------------

-----AGAGAGCACTTCTGGTTTTGGGAT------------CATCGTTGT

CT--GCCAGAGCACAGG----TCC--TGGGTTAAAAA--CGCTGGTGACA

GC-ACCAGGTCGTCATCAACCACGAAGAG---------------------

--------------------------------------------------

-------------------------GTCCTCTCATCTCTCAACTTCCAT-

--------------------------------------------------

-------------------------CAAACTCTATGTTCCCAGT---TTG

AGGGAAGGGAAATCT-----------------------------------

--------------------------------------------------

--------------------ATGCA-------------------------

--------------------------------------------------

-----------------------AG-----------ACTGGAGCAG----

-CTGCCAGAA------AAACACTTTTTGACCCCAGAGTAGAAAAAT----

----------GATGGCATTGAGAGCTG--------ATTTGCAACT-GGT-

--------------------------------------------------

--------------CAAATTCCAGC---CTG-------------------

--------------------------------------------------

-----------------------------------------------TTT

C-----gacttcttgaactaatcttaagcaaggaagact-gagccccag-

----TGA-------------------------------------------

--------------------------------------------------

---------------------------------------------AG---

-------AC-------tgtgtgtgtggtctttttgagacagggtttggct

atgcaatt--------cagactggccttgaactcactttgtag-cccggc

tggccttgaactcacagcaatcctcctgcctcaacctcccgagtgctggg

actacacaagtgtgccaccacaccctgct-----AG--ACATT--TA---

----TAACCAAGATG-GAAGCTTCCTGTTTTCC-----------------

--------------------------------------------------

------------TGGACTC-AAGGACAAATAGGGGT-------------T

TTCTGT---ACATG------------------------------------

--------------------------------------------------

TTTCT----------AATCCTTAGAAGGATT----CACCA----------

CACCA-CACAGGACACACCCACACACACACACGAAAAAACATGCTTCTCT

TGGGTATGTGGAGTT---A--AATA----CCGA-TTAACGTGTT--AAA-

AGCTGTCATGTAC----ATCA-TAGGCTA-CCAGCGAATCA--CC-----

ACCAGC------C---CCTCAC--CTCTGGAACTTGCAATCTGA

>Le

GGACTGAGGGTCACCAGGC--CTAA-------GGAGGGAAGGATACGAAG

GG-CAAAAAACTCAAGGAGGAAG-CTTT-CGCCCAAGTAA---TCTACAC

A-------------------------------------------------

--------------------------------------------------

----------------------GACA---------------GCGTTTTGA

GGA-----------------------------------------------

--------------------------------------------------

ATGTGC-GCATCG-------------------------------------

--------------------------------------------------

--------------GAACTTCTCTCCCAGCCCTCAT--------------

--------------------------------------------------

------GGGCCTGCTGCTGTGCAAC-AGCTACCAAAGCAGGCCC---TGC

CGATCAGG------------------------------------------

--------------------------------------------------

-------------------------CCTCATCCACTGCTACACTCCTA--

--------------------------------------------------

------------------------------------------------GG

CCGACAGGGACGG-------------------------------------

--------------------------------------------------

--------------------TCACC-------------------------

--------------------------------------------------

------------------------------------GCTCAGGAAACACT

GCCTTAGCGAAGCCGTACGTGGCTGCCAGCCGCCGCAGGAAAAGGC----

------------TGACATCGAGTGCTA--------ATTTGCAATT-GGT-

--------------------------------------------------

--------------CAAATG--CGTCGGCAGCTTA---------------

--------------------------------------------------

--------------------------------------------GGCTTC

C-------------------------------------------------

----GGAGC-----------------------------------------

--------------------------------------------------

----CAA------------------TGAACCCCGGGCCCCAGGGTC----

--------------------------------------------------

----------------------------------ACATTCCTC-------

CACCCAAACTG-GAAACCTCCAAGTCCCCGGGAC----------------

--------------------------------------------------

-----TCCCA--AGGAACGACAAAACAGCAGA-----------------A

TCCCACACGGGCGG------------------------------------

--------------------------------------------------

TTCC-----------AGACCTCCTGGGCTCT--A-AATCA----------

--TCACCCCAG---ACAGTC------------AGCAGCA-AGGCCTCTCC

CGGAGCCACAGGACCAGGAGCACCA----CACG-CTGCTGTGCAGGGGA-

------------C----ACGA-GGGGCTG-CGTGAGA------CTGCAGG

GCCTGCGTGGCTC---CCTCAC--CTCTGGAATTTGCAGTCGGA

Locus 451-6

>B1MMur1

--------------------------------------------------

-----------agccgggcgtggtggcgcacgcctttaatcccagcactc

gggaggcagaggcaggcggatctctgtgagttcg-aggccagcctggtct

acatagcgagttccaggccagccagggctaca-tagtgagaccctgtctc

aaaaaaacaaaa--------------------------------------

--------------------------------------------------

------------

>Mm

CCTGGCAGCCTGGGAAGCTTCCCGGACACCAACACAGAAG--GTATGAGG

CACTGGCACACACATGCTATGCCATGCATGCGGCTTTT------ACTCAT

TCAGTCATTCA--------CCAGTCCATCCATCCATTCATGCAGACAACG

ATCCATAATGCGTTCATTCATTCATTCATTGCGTTCATTCATTCATTCAT

TGGTACACAGATCCACTCTTCTGCGTTCATTCACCCACA--TTCCTCAG-

-----CACACTTCGGCCCCTATGCACACTCATCC----ACGCACACACTC

ATACACTCAGCGAATGC----------ACTGAGTTCCAGGCCCCATTTTC

AACTGGGGACCTGGCC-----TCACACAAA-CTAGCCCTG----------

---------TTCTCTGGCCTGGGAAAGATCCTTAAAAA-CCAAAATAAGG

--------------------------------------------------

----------------AATTAAGAG---AACTGTCAGATGACCTGCCTAC

CACA-TTGGAAGTTAAAACGGG-------------AACCCCACAGCTAGA

TGGAAG----------GCTCTGG----AAAGTCTCTGGCAG---------

--------------------------------------------------

------------------------AGGGGAAGACAGGAGGGGGCAGGAGC

T--GGGATAGAG--ACAGGGCTCTCCATCTTAT-------------AAAG

AGCAATAAG---gccagtcacagtggtgcatgactttagccccagcactc

aggaggcagaggcagg-tgaatctttatcatttcaagaccagtctgggct

acataattagtttcaggtcagctagagctacattagtgaga---tgtccc

aaataaataaataaataaataa----------------------------

-ATAGATAAATAAAT----GCAATTAAGAC-ATAGGAACCAGGAGCCA--

-GGAAAGCAAAGATAGAAAGGGCAGAG-TTCTAGAG---CCCAGTAGGTG

ACTTCAGAAGCTGGTGTGA--AGTGAGAGGAGGGAGGAGGGAGGTGGCAG

TATGAGGGTCGAATAGGGAGCACAGC--ACAGCAGTGCCCCCTGCAGGCA

GGTGGGGC--AGGTGGGTGTG------AAAGGAGTGCTGAGCCTGCCCCT

TTTCCACCCCAG

>Rn

CCTGGCAGCCTGGGAAGCTTCCCGGATACAAACACTGAAG--GTATG---

--AGGGCCTGGGACGCACGTGCCATGCCTATGGC-TTT-----CGTTCAT

TCAGCCATTCA--------TAGGTCCATCCATCCATTCGTGC---AAAAG

TCTATTCATG--------------------------ATGCATTCATTCGT

TTGCACGCAGATCCACTCTCCCGCATCCGTCCACCCACA--CTCCTCGG-

-----CACACATTGACCCCAGTGCACACTCATCC----ACGCACACAGTC

ACTCACTCACACACTCAGAGAATGTGTACTGAGTTCCAGGCCCTGTTTTC

AATTGGGGACCTGGCC-----TCACCCAAA-CTAGCCCTG----------

---------CTCCCTGGCCTGGCAAAGATCCTTAAAAA-CCAAAATAAGG

--------------------------------------------------

----------------AATTAA-AG---AACTGTCAGATGGCATTCTGAC

AT---TCGGAAGTTAAAATGGGCGCCACAGG----AACCCCACACACAGC

TAGATGGGTTGCTGCTGCTCTGG----AAAGTCTCTGGCA----------

--------------------------------------------------

-------------------------GGGGGAGCCAGGATGGGGCAGGAGC

T--GGGACACAG--GTGGAGATCTCCAC---AT---------------CA

CAAAAGAGC---gattaggccagtcacacacgcctttagtcccagcgttc

aggagacagagccagg-ggaatctttgaagttgaaag-ccagtctgggct

acataattagtttcaggtcagctagagttaca-tagtgaga---tgtctc

aaaaagatagacagacagacagacagacagacagacagacagacagat--

-AGAATAATAAACAT----GTAGTTAAGAC-ACAGGAACCAGGAGCCA--

-AGAAAGCAAGGGCAGAAAAGGCAGAG-TTGTAGAG---CC-AAAGAGTA

ACTTCAGGAGCTGGTGTAA--AGTGAGAGGAGGAAGGAGGGAGGTGGAGG

CAGGAAGGTAGGGTAGGGAGCACAGC--AAGGCAGGGCTCCCTGTAGGCA

AGTGGGGC---------------------TGGAGTGTTGAGCCTGCCCA-

TTTCTATCCCAG

>Mu

CCTGGCAGCTTGGGAAGCTTCCCGGACACAAACATTGAAG--GTAT----

--TGGTATGGGGACGCATAGGCCATGCATGTGGCTTTT------GTTCAC

TCAGTTATTCATT----GGTTCATCCATTCATTCTTTCATGCGCACATCT

ATTCATAATGCAATCATTCGTTCAC-------------------------

----ACACAGCCACGCTCTCATGCATTCATTCACCCACACATTCCTCAG-

-----CACACATTTACCCCAACACATACTCATTCATTTGCTCACACATTC

AGTCACTCACACACTCAGCAAATGTGTACTGAATTCCAGGC-TGTTTCTT

GACTGGGGGCCAGGTC-----TCACACAAA-CTAGCCCTG----------

---------TTCTTTGGCCTGGGAAAGATCCTTAAAAAATCAAAATAAGG

--------------------------------------------------

----------------AATTAA-AG---ACCTGTCAGGTGACACACCTGC

CACA-GTACAAGTTAAACCAGGTGCCATAAG----AACCCACAGCTA---

-----GATCTGCTGCTGCTCT------AGAGTCTCTGGCAG---------

--------------------------------------------------

------------------------AGTGGAAGATAAGAGGGGGCATGAGC

TAGGTCAGAGA---CAGAGAACTCCACAT-AAA-------------GAAG

AGCAATTAG---gccagtcatagtggtgcacgccatttgtcccagccctc

agggagcagaggcaggcggatctctgtaagttc-aagtctgggctatgc-

----attgagctccaggtcagcaagcactaca-tagtgagc---tgactc

aaaat---------------------------------------------

-AAAAAACATAAAAA---GGCAGTTAAGAC-ACAGGAGCCAAGAGCCA--

----AAGCGAGGACATGCAGGGCAGAG-CTCTAAGG---CCCAGGAGGTG

ACTTCAGAAGCTGGTGTGA--AGTGAGAGGAAGGA----TGCAGTGGCAG

G--------------------------------AGTGGACCCTGTGGGCA

GGTCCACCGGGGGAGGGGGGGTGTAAAAAAGGAGTGCTGACCCTAGCCCT

TTCCTGCCCCAG

>Cc

CCTGGCAGCCTGGAGAGCTTCCCGGACACCAACATTGAAG--GTATC---

------------------------------------------------AT

CCATTTATTCA------TGCTTGTTCATTCGCTCTTTCATACACACACCT

GTCCATAGCGCATCCATTCATTCAC-------------------------

----ACACAGATCCACTCTCCTGCATTCGTTCACCCACCCGTTACTCAG-

-----TACACATCTACCCCCACCAC----------TTCATCCACTCACGC

AGTCACTCACTCGCAT-GCTCAGCAAATGTGTCCTCCATTCTAGGCCTTC

TTCTTGACTACAGGCCTAGTGGCACACAAA-CCAGCCCTG----------

---------CTCTCTAGCCTGGGAAAGATCCCTAAAA--TCAAACTAAGG

--------------------------------------------------

----------------AATTAA-AA---GGCTGTCAGACAACACATGTAC

CACA-GTGGAAGTTAAGACAGGCGCCGTAGG----AACAGCACAGCTAGA

TG---GA-CTGCTGCTACTCT------AG--TCTCTGGCAG---------

--------------------------------------------------

------------------------AGTGGAAGATAAGAGGGAGTAGGAGT

GGAGACAAAGA---CAGGGGTCTCCACATTAAAAAAAAAAAA---AAAAG

AGCAATTAG---gccagtcatggaggtgcacacctttagtcccagaactc

aggaggcagaggcacccagatttccgtaagttcaaagacattctgggct-

acatagtgagtttcatgtcaatcagagttaag-tagtgaca---tgtctc

ataat---------------------------------------------

-TAAAAACATGAAAA---GGCAGTTAAGAC-CCAGGAGTCGAGAGCTA--

----AAGCAAGGACACACAGGGCAGAG-TTCTAGAG---CCCAGCAGGTG

ACTTCAGAGGCTGGTGTGA--AATG-GGGGAGGGAGG-----GGTGGCAT

CGGGGCTGA----GAAGGGAGCAGAGA-ACAGCAGTGGTCCCTGGAGACA

CGTGGGGC-TAGTGGGTGTGA------AAAGGGGTGCTGAGCCTGGCCCT

TT-CTACCCCAG

>Oz

CCTGGCAGCTTGGGGAGCTTCCCAGACACAAACATTGAAG--GTATC---

--AGGCACGGGGATGCACATGCCGTGCATGCGGCTTTT------ATTTAT

GCATGTATTCACG--TAGGTCTATTCGTTTATTCTCTCATGC--AGATAT

ATTCACAATGCATCCATTCATTCAC-------------------------

----ACGCAGATCCACTCTCATGCATGCATTCACCCACATATTACTCAG-

-----CACACATCTGCCCT-------------------ACAAGTACACTC

ATCCACGCACACACTCGGCAAGTGTTTCCTGAATTCCAGGCCTTGCTCT-

GACT-GGGTACATGGCC----TTACACAAA-TTAGCCCTG----------

---------CTCTCTGGCATGGGGAAGATCCTTAAAAA-TCAAAATAAGG

--------------------------------------------------

----------------AATTAAACT---GCCCAATG--------ACACCC

CACAGTGGGAGGTTAAGACAGGCG-------------------CCACAGT

TAGATGGGTTGCTGCTGCTCT------AGAGTCTCTGGCAG---------

--------------------------------------------------

------------------------AGTGAAAGAGCTGGC----CAGGAGC

T--GGGACAGA---CAGGAGTCTCCACATCAAA-------------AAAG

AGCAATTAG---gccagtcatggtggtactcacctttagtcccagcacta

gggagtcagagacaggcatatttccctaagttgaaaacca----------

-ttatgagtttcctatgtaactgagttgcagatcagctaga---------

--------------------------------------------------

-GCTAAATAGTGAGA---TGTCTCAAAATC-AGAAACATAAAAAGGCA--

------GTTAAGACACACAGGGCAGAG-TTCTAGAG---TCCGGAAGGCG

ACTTTAGAGCTGGTGTGGC-------GAGAGAGGAAGGAGGCGGTGGCAG

GGGAGTTGA----GAAGG-----GAGA-ACAGCAGTA-------------

---------------GGTGTG------AAAGGAG-GCTGAGTCTGACCTT

TTTCTGCCCCAG

>Se

CCCGGCAGCCTGGAGAATTTCCTGGATACCAACATTGAAG--GTACC---

--AAGCACACAGATGCGTGAGCCACCGCACCGGGT-------------AT

TCATTCATTCA----TGTGCCCATCCATTCATTCATTCACACACACATTC

CTCAATACGCAC-ACACGCATACAC-----------------ACACACAC

ACACACACACATGCACACACACTCATTCATAC-----------ACTCAG-

--------------------------------------------------

------------------CGGGTATATCCTGAGTGTCAGGCCCAGTTCTG

GGTT--GGGAACCTGGCTT--CACACTAAACA--GCCCTGCCCTCCAGGA

G-----CTTTCCTCTGGCCTGGGAGAGAGCCTTAAAAA-CCAAAATGAGG

---agctgggcatgctggtacacacctttgatcccagcactcaggaggca

gagagaggaggcgctctgtgccagcctacactacatagcaagttccaggc

cagctcaaaaagaccaaaaaaaaaaaaaaagaggaattaaaaa---TTGT

CAGATATA---ggctggagagatggctcagtggctaagagcactgggccg

ctcctgcaaaggacctaggttcaattcccagcacccacatggtggctaac

aattgcccataactctagttctggggacccaatgccctcttctgatctcc

atgggtatcacacaacacaggtgcatgtcaggcaatacactcatacacat

gaagtaaaaataa---TATAAA-AA-----CTGTCAGATGGCACATCTGT

CACAGTGAAAGAGAAGAGCAGTGCCACAAGG------CCACCAGCCA---

-----CATGGATTCTCGC---------AG--CACTTAGCAG---------

--------------------------------------------------

-----------------------------------------------AGT

GGAAGACAAGAC--TAGGACGGG-GTGGAGACG------------AAGAC

AGGGAAAAG-----------------------------------------

--------------------------------------------------

------------------GGCAGCTGGGAC-ATGGGAGCCAAGAACCA--

----GAGCACTGGCCACACAGGGAAGT-CCCTGGGG---CCCTGCAGGCA

GCTTCAGAACTTGCCGTGA-------------GGGTGAGAAGAAGAGGGT

GATGACGGGCGGGGCAAG--CACAGC--AGTGGTTTCTGGGGGCCAAAGG

GGTAGGTC--AGGTGGGTGGT--TGGGAGGGGAGTGCTGAGCCTGAC-TT

TCTCTGCCCTAG

>Cf

CCCGGCAGCCTGGAGAGCTTCCAGGACACCAACGTCGAAG--GTA-----

------ACAGGGACACGCACACCATGCCACATGCTAAAA-----------

-----------CATGTGTATACATGCTGCTCGTGC---------------

-------ATCCACACCTTCATTCAC-------------------------

------------------AAATTCACTCGTTCACTCAAACATCAGCATG-

---------------CATCCACTCACACACGTTAGTTCACCTACACATTC

ATTCACTTGCACACACA--------TTTACTCAGCAGTGGCCCAGTTCTG

AGTT--GGGACATGGCC----TCACACAAAAATAGCCCTGACCTGCAGGA

GGGGCTTTCCCTTCTGGCCAGGGAGAGATGCTCGAAAA-TCAAAATAAGG

--------------------------------------------------

----------------AAGCAA-AA------------------------A

ACTGTCAGATGATACACACTG-------------AAAAACAGGTGCCACA

AG-----ACCACTATGGCCA------GGTGGACTAT-GCAG--AACATGA

GTCAGGTCAGAGAGGGCCAAGTCAGTGTGGGGAACATTGGCAAAGCACAG

GAAGATAAGATAGGACCA--GGATCTGGGGCAGGGGTGGAAGGGAGACAG

AT---AGAGAGA---CAGAGATTTCCATGTC---------------AAAA

GGGCAGTTG-----------------------------------------

--------------------------------------------------

------------------GGGCCATGGCAG-CTGAGGGCCAGAACAA---

-GGAACACTAGCCACACAGGGTGGAGG-CCCTGGAG---CCCAACGAGTA

GTTTTAGAGGCTGGAGGGAGGCTG---------GAGGAAGGAAGTGGATT

GCAAGTGGGCATGACTGGGGGCAGGC---------GAACCCAGCCGGTGG

AGGGGTGGCCAGGT-------------GTGAGGACACTGAGCCTGGCCTT

TCTCTGCCCCAG

>Hg

CCCCGCCGCCTGGAGAGCTTCCCGGACACCAACATTGAAG--GTA-CCAG

GCCCCAGGATTTAGGTCACCTCACAGACACACAGTTCTT-----------

----------------------------CATCCCGTCCGTCCATCCGTCC

GTTATAAATGCATTTCATTATTCAC-------------------------

TCCCATGGCTGCGCATCCCTCCACCTGGCTCATACACATTTATTCACG--

---AATGCCTGTCCATCTGCACACTCGGTCACA-----AAGGCGCACACG

AGTGATGACGACCCCT---------GCGCCCCACGCCATGCCCAGCTCTG

GATG-GGGGACAGGGC-----CTCACAAAACA--GCCCTG----------

-----TCCTGTGGGAGGCCAGGGAAAGATTCTAGAAAA-CTACAATAAGG

--------------------------------------------------

----------------GAGCAA-GA---CTCTTTCTAAAGACACACATAC

GCCA-------GTAGAGAGAGGTGCCACGGG---------------CCA-

------CGGG-CTGT-GC---------GGGACGTGACTCAGGCC------

--------------------------------------------------

-------------------------AGGGAGGAC----------------

--------------------------------------------------

-------------------AGGGTTGATGT-GAGGCAGCTCGGAGCCCA-

-GCACAGCCCACGAAAATGAGGCAAGG-ATCTGGGGGGGCCCAGAGCCTG

GAGCGCCTGGCTCCACGGC--AGTCAAGGGCCATACCAAATATTGCT---

-----------AACCAGCACAGAGGCTACAGGGAACAGGGAGGAGCCAAG

TGGCTGGC-AGAAGGGGTGGGGCGGT-ACAGGGGTGCTGAGCCTCGCCCT

TCTCTGCCCTAG

>Cgu

CCTGGCAGTCTCCAGAGCTTCACAGGCACCAACATTGAAG--GTA-CCAA

GTGCAAGGGTAGCTGATGCATGGGGACTTACCACTTGTTCCATGTGCAAT

CACTCAG-TCACACATT--CATTCACCCATGAACTCATTTATCCATCCAA

ACATTCAC-CCCACCCATTCATTCAA------------------CATGTA

ACTGGTTATCCACACATGTATTCATTCACATTCACTCACATATTCATTGA

CTTAACCATGCACTCACTCATTCATCCTACATATTCATTCACAAACACAC

TCATACCCTCTGCAGACATGTCCTGAACACCCAAGGGCCTAGCCCAGTCA

CAGGTTAGGGACAGTCT----TATACAAAACA--GTCCTGACCTCCAGGA

GCATCCATTCCAGCCAAGGAAGCACAAAACAGTGATGT-ACAAATGAAGG

--------------------------------------------------

----------------TAGAAT-AG-------------------------

--------------------------------------------------

-------------------------------------------AGATCTT

CA---AGACCAA---AA-GAGTTTCCCTGT--------------------

-TAAATAAG-----------------------------------------

--------------------------------------------------

------------------GCAATTAG----------------GGCCAG--

AACTAGGAGTGCTGGCCACATAGGCCAAAAACCTGGGACTCAACAAAGCA

GTTTCAGAGGCTGGAGGGG----GAAGGGAAGATGTGGGTGGCA-GGTGG

-AGTATGATCTGGGAGTA---------GAGAACAGGCAGGCAGGCAGGCA

TGATGGTTGGAGGGAAGCGC------AAGGGTAGCACTGAGCCTGGCCTT

CCTCTGCCCTAG

>La

CCTGGCAATCTCCAGAGCTTCACAGGCACCAACATTGAAG--GTA-CTAG

GTGCAGGGATGGCAAACGCA-CCCATTCAGTCACAAAGACATTCGTTCAT

CCATTATCCATCCAAACA-TTTTCATCCACACATTCATTCAACACACAGC

TGTTTAT-CCACACATGT-ATTCATT------------------------

------------CACATTCATTCACCCATACTCATTCACTCACATATT-C

ATTAACTTACCATACATTCATTCACTCATCCCACATATTCACACACACAT

TAATGTCCTCAGCAGATGTGTCCTGAGCACCGAGTGTC-TAGCCCAGTTA

TGGGTTAGAGACACAGCCTTATACAAACAGACTTGTCCT-----CCAGAA

GTATTCCTTCCAG----GGAAGCACGAA-CAGTAATGC-ACATAAGACAA

--------------------------------------------------

-----------------AACAGAGG-------------------------

--------------------------------------------------

----------------------------------------------TCTT

GG---AGACAGAAAGACAGAGCTTCCCTGT--------------------

-CAAATAGG-----------------------------------------

--------------------------------------------------

------------------GTAGTTGGGCCA-CTGCCGCCACAGGCCAG--

AACTAAGAGTGCTGGCCATGTAGGTCAGAAACCTGGAGCTAGACAAAATA

GTTTCAGAGGCTGGAGGAA-GCAAGAGGGAAGATATGGATGGCA-GGTGG

-AATA-GAG-------------------AACAGGCAAGCAGACAGGATTG

GGGGTGGGGGTAGGGAATGC------AAGGGGAGATCTGAGCCTGGTCTT

CCTCTATCCTAG

>Cp

CCCGGCAGCCTGCAGGACTTCAAGGGCACCAACATCGAAG--GTGTG---

--GTGTA-GGGACTCTCCCTGAACATCTCTCAAACCACTC--------AG

TCACATGCTCA------TTATTCAG--CCACATAGGCATCCACACACTTG

CATGCCTGTCCACTC-----------------------------------

--------------------------------------------------

-------------------ACACA-----------TGAATGGTCCAAGAG

CTGCAGGG--AGGGCAATCAG------GTGAAGGCACTGAGCTGGCG--C

TGTCTGCCCTAG

>Sv

CCTGGCCACCTGGACAGCTTCCCAGACACCAACGTCGAAG--GTGGG---

--GCGGGAGCACACGCG-CCTCTTCCTCGCGTGTGTGTG-----------

--------------------------------------------------

-------------------CACACTCACACACACACCCACTACACCCACC

GCCACTGTCAGACACCACCCTCCCTCACCCACATGCTCCTCCCTTCCACC

TGGCCTTTCACGCTCTCACAAACTGACCCCA-------------------

--------------------------------------------------

----------------------------CACAGGCTCACTCAGCAATGCC

CAGGCCCAGAGC-TGGGTGA--GGGACAGGG-------------------

--------------------------TCTTACACAAAACTGCCCTGACCT

CC------------------------------------------------

--------------GTTTCTGGCCAGGGGGAGATATCTGAAAACCAGGCA

AGGG-AGCAAGA---CACATG-GCAGAGGAC---------------AAGA

TGGGAAG-------------------------------------------

--------------------------------------------------

------------------GGCC-CAGGGCC-ACTGCAGCCAGGGTCAGAA

CAAGGAGAGGGGGCCACCAGAACAGAGCCCTGGGTG---CCCAGGAAGGG

GCTTCAGA-GCTGGAAGTG--AGGAGAAGA-GGCGGGGGCCGTGGGG---

-------------ACTTGAGCACAGG----------TGGCCCGGCTGGAG

GCAGAGCA----CTGGGTAC-------AAGTTGGTGCTGA-CCTGTCCCT

TCCTTGCCATAG

Locus 83-7

>PB1D7

--------------------------------------------------

-ttttgtttttttgagacagggtc--tcgctctgtagcccaggctggcct

cgaactcacggcgatcctcctgcctcagcctcccgagtgc----tgggat

tacaggtgtgaaccaccacgcccggct-----------------------

--------------------------------------------------

----------------------------

>Mm

AATTTGTATCCCGAGTATCTGGAAGACAGGCAGACTTTTCGCCACAGCGT

GGTGGTACCTTATGAGCCACCCGAG--GTCTG---taattttgttttggt

ttgtgcgtctt-agagacagttga-------ctccagcctagactgatgt

tgactttctagcaacccgtttgcctcaccctcctgagtgctagctaggct

tagaggtgcaagctgccgtgcccagccc---AGGGTCTA---CTTT-AAC

-AG-CAGTCTCTGGGAGAAGGGGCTT-----------------CCCCATC

C-------------------------------------------------

-----------------AGGCGGGAAATAGAGA----CGCTGAGTCCGGT

TCCCT-----------cccatgctaa-----------gcaagtgttggg-

--------------------------------------------------

-------------------------------------------CCCCACA

GCT----------CCAG---------CAGGTGTGCCGAACAGG--TGGAA

TATCCCTACTCTACAACTAAAA--CTGAAACTTAT---------------

-----TAGAGGCT----------ATAGCCAGCCATTCCCGGCTGCTGCAG

GTCACCTGTAGTGAGGTAGGGAGCGA------------------------

--------------------------------------------------

-------------------CTTCACCTGGATCCTGTGTCTTCCCCCAG--

GCCGGCTCTGAGTATACCACCATCCACTACAAGTACATGTGTAATAGCTC

CTGCATGGGGGGCATGAACCGCCGACCT

>Rn

AATCCGTATGCTGAGTATCTGGACGACAGGCAGACTTTTCGGCACAGCGT

GGTGGTACCGTATGAGCCACCTGAG-------------------------

--------------------------------------------------

GTCGGCTCCGACTATACCACTATCCACTACAAGTACATGTGCAACAGCTC

CTGCATGGGGGGCATGAACCGCCGGCCC

>Cc

AATATGCATGCCGAATACCTGGATGACAAGCAGACTTTTCGGCACAGTGT

GGTGGTGCCCTATGAGCCACCTGAG--GTCTG---ttcttttgggttggg

ttgggttgggttgaagacagggtttgatttgctctaccccagactgatgt

tgaacttgcagcaactctcttgcctcgggctcctgagta----ctggact

tataggtgtgaactactgtgttcaggct---GAAGTTTA---CCTT-AAG

AAGAGGGTCTCTGGGAGAAGAGAGTTGGGAGGGGTTCAGGCTG-------

-AAGTTTACCTTAAACAAGA-GGGTCTCTGGGAGAAGAGAGTTGGGAGGG

GTTGTCGGTGGCCACTCAGGTGGGAGGTAGAGG----GGCTGAGTCCTGT

CCTGT-----------taccatca--------------------------

--------------------------------------------------

-------------------------GTGT----------CCTTACTACAG

GTTCCCTGTGGTGGGATTGGGAGTGG------------------------

--------------------------------------------------

-------------------CTTCACCTAGGTCCTGTGTCCTCCCTTAG--

GTTGGCTCTGACTGTACCACCATCCACTATAACTACATGTGTAATAGTTC

CTGCATGGGGGGCATGAACCGGCGGCCT

>Oz

AACTTGCGAGCCGAGTATCTGGATGACAGGCAGACTTTCCGGCACAGTGT

GGTGGTGCCGTATGAGCCACCTGAG--GTCTG--------ttg-tttggt

ttga-tttct----------------------actagcccagactgatgt

tgaccttgcgacaaccctcttgcctcaggctcttgagta----ctgg-ct

tgtagg-ctgatctatcatgcccagcct---GAGGTTTA---CTTGAACA

AGA-GGGCCTCTAGGAGAAGAGAGCAGAAGGGGGTTGGTGGTGGCCACCC

A-------------------------------------------------

------------------GGTGGGAGGTAGAGA----GTCTGAGTCCTGT

CCCCT-----------caccatcatca--------------tgcttgggg

tacaacccagag-------cctcacacat-gctaggcaagtggtgtaccc

ca------------tctccagccc----ACTTGCTTCTCATCC----A-G

CACCC---TGCTTCTCCAG-------GAGGCATGCAGAGCAGG--TGGGG

TGTCCCACCTGCAC----AA----CTGAAACTGA----------------

-----GGCTTCCT----------GGTTGCTCCAG----------------

GTCGCCTGTGGTGGGATCGGGAGTGG------------------------

--------------------------------------------------

-------------------CTTCACCTGGGTCCTGTGTCCTCCCCCAG--

GTCGGCTCTGACTGTACTACCGTCCACTACAACTACATGTGTAATAGCTC

CTGCATGGGGGGCATGAACCGCCGGCCC

>Se

AATTTGCGTGCAGAGTATCTGAATGACGAACACACTTTCCGGCACAGCGT

GGTGGTGCCTTACGAGCCACCTGAG--GTCTG------------------

--------------------------------------------------

------------------------------------------ATTGCACA

C-CTGGGTCTCCGGGCAGAGGG--CTAAAGGGAGGTGAAGGGCTGGGCCC

C-------------------------------------------------

-----------------TGTGTGGGGGGGGGGTGG---------------

--------------------------------------------------

----------------------------------------------accc

cagggcctta---tccctgggccc----ACCTATAACTTTTTCAT-CA--

-GCCC---TCAGTCTGTGG-------AGTATACAGGACACACGG-TGGAT

TAGTTTCCCTCCGTAGTTAAA---CTAAAACTGC----------------

-----CAGATGCC----------AGTGGCTCACTCT-----AATCCTAGC

CACTCAGGAGTCTTCAATCTGAGGATCCCAGTTGGAAGCCAGGCTGGGCA

AGATCCATGAGACTCTTTAACACCAATTAATTACCAAAAACTAGAAGTGC

CACTGTGGCTCACAATG-CTAGAGCACTGTCCTAGGATGAAAAAAGAAAG

TAAGTAAACCTTTCCGAGGCTCCATCTGGGGCCTGTATTCTCCAGCAG--

GTTGGCTCTGACTGCACCACCATCCACTACAACTACATGTGTAACAGCTC

CTGTATGGGGGGCATGAACCGGCGGCCC

>Asp

AATTTGCATGCGGAGTATCTGGATGACAGACAAACTTTTCGACATAGCGT

GGTGGTGCCCTATGAGCCTCCTGAG--GTCTG------------------

--------------------------------------------------

------------------------------------------GTTTTGGC

CACTGGGTCTCTGGGAGGGGG---CTGGA-GGGGCTGTAGGAG-------

--------------------------------------------------

-------------------------GGAGGGGG---CTTTCTATTGCCCC

CTTTTT----ctttttttcttcccacc------------tgtgcttggga

tccagcccacag-------cctcgagcat-gctagacaagtgctctacca

ctgagccaca-----ccctggcc-----AGTATCCTTCTTACTCAATGCC

CACAT---AGCCCTGTA---------AGGTGGGCAGAACACA---TGGGC

TGTCCCCACTCCACACTGAAGAAACCAGAGCTGC----------------

-----GGCCTCCC----------TGTTGCTACAG-------GTCTCCCA-

-GGGTAGGTTGG--------------------------------------

--------------------------------------------------

-------------------CTTCACCTTGGGCCTGTGTCCTCCCCCAG--

GTTGGCTCAGACTGTACCACCATCCACTACAACTACATGTGTAACAGCTC

CTGCATGGGGGGCATGAACCGGCGGC--

>Cf

AATTTGCGGGCGGAGTATTTGGATGACACCCACACTTTTCGACACAGCGT

AGTGGTGCCTTATGAACCACCTGAG--GTTTG------------------

--------------------------------------------------

------------------------------------------GTGT----

----GGGTCTCTGGGGGGAGGATTCTGGAAGGGGTTGTCAGTGACCACCC

A-------------------------------------------------

------------------GGTGGGAGGTAAGGGG----------------

----------ctttcttctgctcctgtgggtg----tgtgttgctgggga

ttgaacctaggg-------cctcaagcat-actaggcaaatagtctacca

ctgagccaca---cccccaggcc-----ACCTGCTTCTTACTTGA-TGCC

TCCAC---ACCCTTGTG---------AGGTATGCAAAGCAGA---TGGGG

TTACCCCACTCCACCTAAAGCTTCCAGAAGCTGC----------------

----------TAG-------------------------------------

--------------------------------------------------

-------------------CTTCCCCTAGGGCTTATGTCCTTTTGTAG--

GTTGGCTCTGACTGTACCACCATCCACTACAACTTCATGTGCAACAGCTC

TTGCATGGGGGGCATGAATCGGCGGCC-

>La

AATCTGCGTGCGGAATATCAGAATGACACGACCACTTTCCGGCACAGCGT

GTTGGTGCCCTATGAGCCGCCTGAG--GTTTG------------------

--------------------------------------------------

------------------------------------------ATTTGGCA

ACTGGGATCTCTGGGAGGACAGGCCAGTGGGGCTGGAGGAGATTGTCATT

GGTCACCCCA-----GTGGAGATAGAGGGTTCTCCCTGCCTTTTTTTCTC

TTTCCTTTTTGTTTTTGGTTGGTTTTTTTTTTTTTTTTTTtGGTTGTTGT

TGTCATCGTCGttttattttatttttgttct---ttagtggtatcaggga

tgaaatccaggg-------cctcatacat-gttaggcaagcccactacca

ctacacccagc---------------------TAATTCTTATTCAGTGAC

CCCCCCCACGCAACCTCAT--------GAGCTATGCAGAGCAGA--TGGG

GTTCCCCTGCTCCTCGGTTAA------GAAACTGAAGCTTCCCAAAGCTG

CAG---GCATCCCT----------GGTTGACACA--------GACCTCCC

CAGAGCCAGGCAA-------------------------------------

--------------------------------------------------

-------------------CCTCAGCTAGGACCT-TGTCCTCCCCCAG--

GTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGCTC

CTGCATGGGAGGCATGAACCGCAGGCCC

>Cp-TDB

AATCTGCACGCAGAATACGTGGATGACAGAACCACTTTCCGCCACAGCGT

GGTGGTGCCCTATGAACCGCCTGAG--GTCTG------------------

--------------------------------------------------

------------------------------------------GTTCGGCA

GCTGGGGTCTCTGGGAGGAGGG--CATCAAGGGGCTGGAAGAGATTGTCG

C-------------------------------------------------

--------------------TGGCCACTGAGGGAGCCGTAGAGGACTTCC

CAACTTT---cttttttctggg-ttgtggggtttttggtggtgttaagga

tggaaccgaggg-------cctcccaagctgctaagcatagcagcacagt

acaatactgtt---cccctcgtgg----TCCTGTGTCCGCTCTA--CCAC

TGAGC---CCCGCTGCTTCTCCAAC-ATCCCTACAAACCTGCGAGGTGGA

CAGAGCCACTTCGCTTCTCAGGTGAAGAAACAGAAGCCACCAGAGGCTAC

AG---GCCTTCCT----------GGTTGCTGCA--------GACCTCCCC

AGGTCTGGTTGG--------------------------------------

--------------------------------------------------

-------------------CTTCACCTGGGACCTGTGCCCTCCCCCAG--

GTCGGCTCCGACTGCACCACCATCCACTACAACTACATGTGCAACAGCTC

CTGCATGGGAGGCATGAACCGGAGGCCC

>Oc-TDB

AATCTCCGTGCGGAGTATTTGGATGACAGAAACACCTTCCGACACAGCGT

GGTGGTGCCCTACGAGCCGCCCGAG--GTCTG------------------

--------------------------------------------------

------------------------------------------GTTTGGCG

GCTGGGGCCTCGGTGGGGAGGGG-CTGGAGGTGGGTGTCACAGACGTTGG

G-------------------------------------------------

--------------------TG-CCAG------AGGGCTTTCT-------

--------------------------------------------------

-----------------------------CCATCTCTCCACC------AT

CCCTG---AGGTGTGTG---------AACAGG-------------TGGGT

CTTCTCTATAGTG-------------------------------------

-----------------------GGCGACT-CA----------AGTTCGC

AGGGCTGGCTGG--------------------------------------

--------------------------------------------------

-------------------CCTCATCTGGGCTCTCTGTTCTGC---AG--

GTTGGCTCTGACTGTACCACTATCCACTATAATTACATGTGTAACAGCTT

CTGCATGGGGGGCATGAACCGGCGGCTC

Locus 425-9

>ID4

--------------------------------------------------

------------------------ggggctgggga-tgtagctcagtggt

-agagcgcttgcctagcatgcgcgaggccctgggttcgatccccagcacc

g-caaaaaaa----------------------------------------

--------------------------------------------------

-------

>Mm

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGACTGCACTTGGGAGGACT

GTTCCCTAGGATGTTGACTTCTCAGTGCTGCCCACTC-------------

----GGGATACA--GAG----AATGTTGGGAGCAA---------------

--------------------------------------------------

--------------------TAGATGAGAG-TACATTTTGGAGTC-----

--TAAGCACCGGTGGTTTGCCTT---------------------------

--------------------------------------------------

-------------------------TTAAC------CTTCTTTAGGAAGT

AGA--GGTGATGACTG-------TGCAGGATTATGAGGACCATGCAAT-A

AAAA--TCA---GTGGGGAAG-------ctgagggatgca-ctcagtaat

aagagtgcttgc-tttcacgcacttggctcttggttcaat-cccagtacc

g-c---ttcttttttattttt-----------------------------

--------------------------------------------------

---------------AAGATG--AAA------------------------

--------------------------------------------------

--------------CTA--CA---ccgggggtggtggcacacgcctttaa

tcccagcactcgggaggcagaggcaggtggatttctgagtttgaggccag

cctggtctacaaagtgagttccaggacagccagggctatacagagaaacc

ctgtctcgaaaaaacaaacaaacaaaaagatgaaaa---CTAGCGGGGGG

GGGGGGGC---ggctggagagatggctcagtggttaagagcactgactgc

tcttttggaggtcctgagtttaattccaagcaaccatatggtggctcaca

accatccataatgagatctgatgccctgttctggtgtgtctgaagacagg

gacagtgtccttacatataaataaataaataaataaataaatcttaaaaa

gaaagaaa---gaaagaaaaCTAGC---ccgggcagtggtggcacatcgc

cctttaatccccagccacttcggcaggcagaggcaggcagatttctgagt

ttgaggccagcctggtctacagagtgagttccaggtcagccagggtacac

agagaaacccagtctcggggaaaaagaaagaaaagaaagaaagaaaaaga

aagaagacaTTACCA---CTTTTATTTA----------------------

--------------------------------------------------

-----------TAACTAATTAGTCAGTTTA--CAGGTGGACATTTGTAAA

ACAGAA--AGACCTT-----------------------------------

----------------------------------------AAC-AGTTCA

AGATGGGTAAC-G----------A-TGCTAGGGTTGTCTG---TTG-GGG

TGCC--CAG-----GTGGAAGGAGCAGAGCCCTGCTCACTGGAGTGGCGT

GCTGGCA

>Rn

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGACTGCGCTTGGGAGGACT

GTTCCCTAGGATGCTAACTCCTCAGTGCTGCCAACCA-------------

----GGGATGCA--AAG----AATGTTGGGAGTGA---------------

--------------------------------------------------

--------------------TGGGTGAGAG-TACATTTTGTAGTG-----

--TAAGCACCGGTGGCTTGCTTG---------------------------

--------------------------------------------------

-------------------------TTAAC------CTTCTTTAGGAAGT

AGA--GGTGATGA--G-------TGCAGGATTATGAGGACCA-GTAAT-A

AAGA--TCA---GTGGGAAAA-------c-gagggatgtagctcagtaat

aagagtgcttccttttcacgcacagggctgtaggttcaatccccagta-c

gac-ttcttttttttattttt-----------------------------

--------------------------------------------------

---------------AAAATG-AAAA------------------------

--------------------------------------------------

--------------CATACCA-----------------------------

--------------------------------------------------

------------------TTTTTATTTA----------------------

--------------------------------------------------

------------CAATAAGTTT-----------------ACATTTGTAAG

ACAGGA-GGGACTTT-----------------------------------

----------------------------------------AAAGAGTGCA

AAATGGGTAAC-G----------G-TGCTAGGGCTGTCTG---CTG-GGA

TGCC--CAG-----GTGGAGGGAGCAAAGCCCTGCTCACTGGAGTGGAGT

GCTGGCA

>Mu

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGACTGCCCTTGGGAGGATC

CTCTCCTAGGACTCTTACTCCTCAGTGCTGCCCAC---------------

----GGGATGC--AAAG----AATGTTGGGCGTGG---------------

--------------------------------------------------

-----GACTGTTGGGAGTGATGGATGAGAG-TATTCTTTGGAGTC-----

--TAAGCACCGGTGGCTAGCCTG---------------------------

--------------------------------------------------

-------------------------TT-AC------CTACTTTATGAAGT

AGA--GGTGATGAGTG-------TGCAGGCTTATGATGACCACGCAGT-A

AAATTATCA---GTGGGAAAA-------ctgagggatgtagcccagtgaa

aagagtgcttggttttcatgcacagggctctaggttcaattcccagcacc

-ac--------ctttcttttt-----------------------------

--------------------------------------------------

---------------AAGATGAAAAA------------------------

--------------------------------------------------

--------------CGTACCA-----------------------------

--------------------------------------------------

------------------CTTTTATTTA----------------------

--------------------------------------------------

-----------TAACTAATAAGTCAGTTTATGGGT-GGGACATTTGTAAG

TCAGGA-GGGACCTT-----------------------------------

----------------------------------------AAAGATTGCA

AAACGAGTAACTG----------AGTGCTAGGGCTGTCTA---CCC-GAG

TACT--CAG-----GTGGAGGGAGCAAAGCCCTGCACACTGGAGTGGAGT

GCTGGCA

>Cc

TTAGCTTCTGGGCAGTCTTTCCG--GTGAGTGACTGCGCTTGAGAGGACC

CTTCCCTGGGATGCTGACCCCTCAATACTTGTCCTCCAGAATGCAAAGAA

TGATGGGAGT----AAG----AATGTTGGGAGTG----agccgggcgttg

gtggcacatgcctttaatcccagcactcgggaggcagaagcaggtggatc

tctg-tgagcctgatctacagagccagttccaggacagcctccaaaacaa

tacagagaaaccctgtctcgaaaaaccgaaaaaagaaaa---AATGTTGG

GAGTGA--------------------------------------------

--------------------TGGATGAGCG-TGCACTTTGATGTA-----

--TAAGCACTAGTGGTGAGCCTC---------------------------

--------------------------------------------------

------------------------------------CTCCTTTATGAAAT

AG---TGTAGTGAGTG-------TGCAG----ATTGTGAGGACCATGT-A

AAAA--TCA---GTGGGAAAG-------ttgagaaatg------------

-----tgcttacttttcatgcacggggctctaggtgcaatcccctgttcc

ttttttttttttttttttttt-----------------------------

--------------------------------------------------

---------------ACA-TGAAAAC------------------------

--------------------------------------------------

--------------CATACTG-----------------------------

--------------------------------------------------

------------------CTTTTACTTT----------------------

--------------------------------------------------

------GTAACTAACTTATAAGTCAGTTTTTGGGT-GGGACATTTGTAAA

ACAGGA-GGGCCCTT-----------------------------------

----------------------------------------AAAGAGCGCA

AGATGGGTAACTG----------AGTGTTAGAGCTTTCTA---CTG-GGG

TGCT--CAG-----GTGGAGGGAGCAAAGCCCTGCACACTGGAGTGGCGT

GCTGGCA

>Oz

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGTCTGCGCTTGGGCGG-CC

CTTCCCTGGGACGCTGACCCTTCCAT-GCTGCCCACC-------------

----GGGAATGC-AAAG----AAT-GATG--AGAG---------------

--------------------------------------------------

------------------------------------------------TA

AGAATTTTGGGAGTGATGGATGAGGGAGAG-CGCACTTTGGAGAA-----

--TCAGCACTGGTGGAGAGCTTG---------------------------

--------------------------------------------------

-------------------------TT-AC------CCCCTATATGAAAT

AGA--TGTAGTGAGCG-------TGCAG-----------GGCTGCAGT-A

AAAG--TAA---GTGGGGAAG-------ctgagggatgcaggtcagt--g

atgagtgcttgattttcatgcacaaggccctaggttcaatccccaatacc

-attattattattatt----------------------------------

--------------------------------------------------

---------------AAAA-------------------------------

--------------------------------------------------

--------------CATACTA-----------------------------

--------------------------------------------------

------------------TTTTTCCTT-----------------------

--------------------------------------------------

---------CATAACTAATAAATCGGTTTTTGGGT-GGGACATTTGTAAG

ACAATA-GGGACCTC-----------------------------------

----------------------------------------AAAGAGCACA

AGATGGGTAACTA----------AGTGCTGGAACTGTCTG---CTT-GG-

-TCT--CAG-----GTGGAGGGAGCAAAGCCCTGCGCACTGGAGTGGCGT

GCTGGCT

>Se

TTAGCTTCTGGACAGTCCTTCCG--GTGAGT----GCGCTTGGGAGGTCA

TC---------------------AGCGCTGCCCACCA-------------

----GGGATGCA--AAC----AAT-GTTGGGAGTG---------------

--------------------------------------------------

------GTAGATGGGAGTG-TACGGGGGGGGGGCTGTATAAAT-------

--GAAGCACTAGTGGTGGGCCTG---------------------------

--------------------------------------------------

-------------------------TTAAC------CTTTAT---GAAGT

AGA---------------------GCAGGATTGTGAGGAGCATGCAGT-A

AAA---TCA---GTGGAAAAG-------ctggggatgtatagctcagtgg

tcgaatgcttgtctagcatgtgcagggccctaggttcagttcccagtagc

ttttttttttttt-----------ttttctttttgaagcaggttctccct

gtagccccagctgtcctggaactcactatatagaccaggctggccttgaa

ctcacagagatccgcctgcctctgcctcccaagtgctgggactacaggcg

tgtgccaccatgcccggct---CCCCGGTAGCTTTTAAAGATAATCGATG

AATG---ggagctggagagatggttcagtggttaagagcatcagctgctc

ttgcaaaggactggggttcaattcccagcaccacatagtggctcacaacc

accagtaactccagttccaggggatccaacgccttctgacctttataggt

attgcgctacacagtgtacttacctacatgcaggcaatacgctcatacac

ataaaaataatt---GAAAAAAGATA------------------------

--------------------------------------------------

--------------CCA---------------------------------

--------------------------------------------------

------------------CTTTTGCTTT----------------------

--------------------------------------------------

----------ATAATTAACAAATCAGATT-GTGAGTAGGACATTTGTAAG

AAGGGA-GAGACCTCTGTGAGGGGGTCTGGCACGCTGGCCCTGGCACCCT

ACAGCCATAAAAAAAAAAAAAA------GGGAGAGACCTCAAAGTGTGCA

GGATGGGTAACTG----------AGTACTTGAGTTGTCTGTA-CCT-GGG

TGTT--CAG-----GTGGCGGGAGCAAAGCCCTGCACACTGGAGTGGCGT

TCTGGCA

>Jj

TTAGCCTCTGGACAGTCCTTCCG--GTGAGTCACTGCGCTTCAGGGACCA

CTTCCCTGA--CCTTGGCTT---AGTACT-----GCC-------------

---------AAG--TGA----AAGTGATTGATAGGGTTTACATCAGGGT-

--AAAAAAGTGAACGAGT---gccagatgt-ggtggcgcatgcctttagt

tagcactccggaggcagaggatctctgggagttctaagccagcctgaaac

tacatagagaactccaggtcagcctgggctacagcgagatcctgctcgaa

aaacaatcaaaaccacaaaaaaaaaa---AAAAAAGTGAACACGT-----

--------------------------------------------------

-------TCTGGTGGTGAGCCTA---------------------------

--------------------------------------------------

-------------------------TTACATA----CTCCCTTACAATGT

GGA--GGTAGTAAGTA-------GGCAGGATTGTGAGGATCCTGCAGT-C

AGA---TCA-----------------------------------------

--------------------------------------------------

---------------AGGAAG--------ttttgtcttttgaggtagccc

aggctgacctggaattcactatgtagtctcaggctgtcctcgaactcaca

gagatcttccttcctctgcctaccaagtactgggattaaaggtgtgcgtc

accacccggct---AAGGCCA-----------------------------

--------------------------------------------------

----------------CCTTTTTAACTG----------------------

--------------------------------------------------

-------------------------------------ATGACAAATATAA

CAACTTTTCCTCTATAATTAATGAATCAGTTT-GTGAATAGGACATTTGT

AGGATGGGA-GGGAC--CC-------------------------------

----------------------------------------AAAAGGATGC

AGGACACATAACCC----------------GGTCTGTCTACA-CCT-GGG

TACT--CAG-----GTGGAGAGAACAAAGCCCTGCACACTGGAGTGGCGT

GCTGGCA

>Pca

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGAGTGCGCCTGGGAGGCCT

TTTCCCTGGGACTCTGGCTCCTGACTCCTCAGGATTGCCCGACGGC----

----GGT-GCC--AAAG----AATGTTGGGGACGA---------------

--------------------------------------------------

-----------TGGG-GGTG------TATCCCAGGGAACAAAAAG-----

--TAAGCACTGCTGGCGAG-------------------------------

--------------------------------------------------

------------------------------------CCTGTTATCTCCTT

TATAGATTAATAAGTA-------GGCAGTGTTGTTAGGATCGTGCAGT-A

AAA---TCA-----------------------------------------

--------------------------------------------------

---------------GTGAAAAA---------------------------

--------------------------------------------------

--------------CAGGCCA-----------------------------

--------------------------------------------------

------------------CTTTTACTTT----------------------

--------------------------------------------------

----------ACAGTTAGACGATGTGTTTTGTGAATGAGGCATTTGTAAG

ATGGGA-GGGACC-CC----------------------------------

----------------------------------------AAAGGGTGTA

CGAAGGGAAACTT----------GAGTGCTGAGGCTGTCTGCACCT-GGG

TGCT--CAG-----GTGGAAGGAGCAAAACCCTGCACACTGGAGTGGAGT

GTTGGCA

>Cf

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGACTGCGCCTG-GGGGCCC

CTTCCCTGAGGCCCTGGCTTCTGACTCCTCCGTACTGCTCTCCAG-----

----GGG-TGC--AAAGG---AATGTTAGGAGTGA---------------

--------------------------------------------------

----------------GGGATGAG--GATG-TACCTTTGGTGCATGAAAG

--TAAGCACTGCTGGAGAG-------------------------------

--------------------------------------------------

------------------------------------CCTCTTACTTCCTT

TATACAGGTACTAAGT-------G-CAGTGTTGTGAGGAAGGCGCAAT-A

AAA---TCG-----------------------------------------

--------------------------------------------------

---------------CTGAAAAATAC------------------------

--------------------------------------------------

--------------AATACCA-----------------------------

--------------------------------------------------

------------------CCTTTACTTA----------------------

--------------------------------------------------

-----------------GAAAATCTGTTTGGTGATTGCGGCATTTGTAAG

ACTGGAAGGGAC-TCC----------------------------------

----------------------------------------AAAGGGTGCA

GGAAGGGAAACTG-----------TG--------CTGTCTGCACCT-GGG

TGCT--TAG-----GTGGAGGGAGCAAAGCCCTGCACACTGGAGTGGCGT

GCTGGCG

>La

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGACTGCCCCTGAGAGACCC

CTCCCCTAGGGCCCTGGCTTCTGATTCCTTTGTACTACCTGTCAGG----

----GATGCAAAGGA------ACGTTGGGGGGTGAT--------------

--------------------------------------------------

--------AAATGGGAAGGGGGG-----CACTTCAGAATTCAAGAAAGGA

AATAAGCACTCTTGTAAAGGTAA---agccaggctagtggatcagtcctg

taattccagcaaactggtaggtgaagcaggaggatcggaagtcgaagaca

agcttaagtaacttggggagaccctgtctcaaaatccaaaataaaa----

-AAGGGCCAGGGGTATAGCTCTGAGCTCGAT-----CTCTACTGTCATAA

AATAAACAGCAGAAGGACTAAGTCTGTGCAGTGTTGTGAGAAT-CATGAA

ATAAAATTA-----------------------------------------

--------------------------------------------------

------CTTTGTAATTAGTAAGTCATATTTGTAAATGGGGCATTTGTGAG

ACTGGA-AGG--ACCC----------------------------------

----------------------------------------AAAGG-TGTA

AGAAGGGAAATTGAGGAAAGAAAGATTGATAAGGCTGTGTGCAC-T-GGG

AA----CAG-----GTGGCGGGAGCAAAGCCCCGCACACTGGAGCGGCGT

GCTGGCA

>Cp-TDB

TTAGCTTCTGGACAGTCCTTCCG--GTGAGTGGTTTCATCTGAGGGGCCC

CTCCCCAGCTTTGTGCTGCTGTCCAA------------------------

----GGGGCAGAGGA------ATGTTGGGGATGAC---------------

--------------------------------------------------

--------------------AGA---------------------------

--------------------------------------------------

-------------------------GAATG------CACCTTT----AGA

TTTAGAAAAGGAAATA-------AGCACTGCTTTGTCCAATGGAGGTGGT

AAG---TCT-----------------------------------------

--------------------------------------------------

---------------GCAGGGCTGT-------------------------

--------------------------------------------------

--------------GAGGAC------------------------------

--------------------------------------------------

------------------AGGTTACTTG----------------------

--------------------------------------------------

----------GTAATTAGTAGGTCAGCTTTGTAAACGAGGCATCAGAGGG

ACGAGA-GGGA--CCC----------------------------------

----------------------------------------AAAGGGTGAA

GGAAGGGAAGC-------------AGTGTGAGGCCCATCTGCACCC-GGG

--CG--CAG-----GTGGAGAGAGCAGAGCCCTGCACACTGGAGCGGCGT

GCTGGCC

>Sv

TTAGCTTCTGGACAATCCTTCCG--GTGAGTGGCTGGCCTGGGAGGCCTC

TTTCC-TAGGACCCTGGTTCCTCACGGCCCATTACAGCCCGTCAGA----

----GAT-GCA--AAGG----AATGTTGGGGGTGA---------------

--------------------------------------------------

-----------TGG-ATGGGGTAG--TACCTCTCAGGTATTAAAAAAGGA

AATAAACACTGGTGGTGAGACTG---------------------------

--------------------------------------------------

-------------------------TT-GC------CGCCTTT---ACAA

AGTAGAGGTATTAAGT-------CTACAATAGTTTTAGGATTATGCAATA

ATA---TCA-----------------------------------------

--------------------------------------------------

---------------AAGATA-----------------------------

--------------------------------------------------

--------------CTA---------------------------------

--------------------------------------------------

------------------CTTTTACTTT----------------------

--------------------------------------------------

----------GCAGCTGTTAAGTCAGTTTTATAAATGGGGCACTTGCAAA

TAGGAG--GGACTCCC----------------------------------

----------------------------------------AAAGTGTGTG

GGAAGGGAAACTG-----------AGTGCTAGGCCTGTCTGCACCT-GGG

AGTT--CAG-----GTGGAAGGAGCAAAGCCCTGCACACTGGAGTGGCGT

TCTGGGG

>Gg

TTAGCTTCTGGACAGTCCTTTCG--GTGAGTGACT-------------TG

CACCCCTGGTCGCCTGGCTCCAGACTGCTCATTACTGCCTGCCAGG----

----GGT-GCA--GGG-----AGTGTTGGGGGTGA---------------

--------------------------------------------------

-----------TGCTGGGGGGTAT-----ACCTCAGGGGACAAAAAAGGA

AATAAGCGCACTGGTAGCGAACT---------------------------

--------------------------------------------------

-------------------------TGTTAC-----CTCCTTT---ATAA

AGTGGAGGTAATAAGT-------CTGTGTAGTGTTAGGGTCATGCAGTAA

CTAC--TCG-----------------------------------------

--------------------------------------------------

---------------ATGAA---agccacgcgtggtggcgcacgcttgta

atcccagtacttgggaggctgaaacagaaggatccgggttcatggccagc

ctcagctacttagtgaggccct----------------------------

--------------CCGCAA------------------------------

--------------------------------------------------

------------------CTTCGTGAGACCTGGTTTCAATATAAAGGATA

AAAAATA---gggccgggggtgtagctcagaggtagaatgcccctgggtt

caatcactggtaccgcaaaaataaataaaaaaataaaaataaagaataca

aaaaata---gagctggaggtgtagcttggaggtcgattgaccctgggtt

caatccccagtactgcaaaaataaagtcgacgaaaaa---GATACAA---

CTATTACTTTGCAGCTAG----TTGGTTTTGCAAATGGGGCATTTGTAGG

ACAGGA-GGGA-ACCC----------------------------------

----------------------------------------AAAGGGTGCA

GGAAGGGAAACTG-----------AGTGCTAGGGCTGTCTGCACCT-GGG

GGTC--CAG-----GTGGAAGGAGCAAAGCCCTGCACACTGGAGTGGCGT

GCTGGCA

>Oc-TDB

CTGGCGTCTGGACAGTCCTTCCG--GTGAGTAGCTGCAGCTGGGAGGCCC

ACCCCGGGACCCCCGCCCCCACCCCCGCGCA-------------------

----GTGCAGGGTGCAC----AGGTGAGCCTGCGG---------------

--------------------------------------------------

--------------------------------------------TGCCGC

GAGCCTCAGCAGGAGAGCCGCA----------------------------

--------------------------------------------------

------------------------------------CTCTCTGCGCTTAA

AAT-----------------------------------------------

--------------------------------------------------

---------------------------------CAGCTTTGAACCTGCA-

-GCGGCGGC-----------------------------------------

----------------------------------------AGGAGGCGGG

GCAGGCGGGG-------CTCCCG-AGTGCTAGGGCCGTGCTGCCCTTGGG

AGCCCACAG-----GTGGAGAGAGCAAAGCCCCGCACACTGGAGTGGCGT

GCTGGCC

Locus 435-10

>ID_B1

--------------------------------------------------

--------------------------ggggct-ggggatgtagctcagtt

ggtagagcgcttgccta------gcatgcgcgaagccctgggttcgatcc

ccag-caccgcataaaaccgggcgtggtggcgcacgcctgtaatcccagc

actcgggaggt---------------------------------------

--------------------------------------------------

-ggaggcaggaggatcagaagttcaaggtcatcctcggctacatagcgag

ttcgaggccagcctgggctacatgagaccctgtctcaaaaaaaaaaaa--

--------------------------------------------------

-----------------------------------------------

>Mm

GGCATATCTGTGCTGGAGGCCCTGGGAGATGGGGAGTTCATCAAGTGCCT

GCACTCTGTGGGGTGCCCTCTCCCCTTAAAAA--GTAAGTACATTCTTTC

C---AGATCGAAGGTGGAGGGA----gaagtt-ggggaag-ggttcagcg

ggtggggtgctctcctg------gcgtgcatgaggccctgagtttgat-c

ccag-acaccaaataaactgaacatgctgggtcaggcctaccaccccagc

tcgcaggagt----------------------------------------

--------------------------------------------------

------caggagaaccagaagtttcaggtccttctcagctccgtagctgg

ttcgaggccagcctgg----------------------------------

-AGACTTGGG---CAGGGA-------------------------------

--------------------------------------------------

----------------TGTG--CACCACAAGCTCACTG------------

-TGGCTTGC---TTGTTTGCAG--AGCCTTTGGTCAACAACTGGGCC

>Rn

GGGACCTCTGTGCTGGAGGCCCTGGGCGATGGGGAGTTTATCAAGTGCCT

CCACTCCGTGGGGTGCCCTCTCCCCTTAAAAA--GTAAGTACCTCCTTTC

--------CAGATCAAAAGGGA----agagttcggggaag-ggcttagtg

ggtaggatgctcaccca------gggtgcaagaggccccgagtttgat-g

ccgg-acaccaaatcaactgatcatgctgggacaggcctatcaccccggc

actcagg-------------------------------------------

--------------------------------------------------

------agtcagaaggatcagttccaggtccctctcagctccgtagctgg

ttcgaggccagcctgg----------------------------------

-AGACTTGGG---CAGGGA-------------------------------

--------------------------------------------------

----------------TGTGTGTATCGCAAGCTCACGAC-----------

-TGCTTTGC---TTGTTTTCAG--AGCCTTTGGTCAACAACTGGGCC

>Mu

GGGGTGTCTGTGCTGGAGGCCCTGGGCAGCGGGGAGTTTATCAAGTGCCT

CCACTCCGTGGGGTGCCCTCTTCCCTTAAAGA--GTAAGTACACCCTTTC

C---AACCCAAAAGGGAGGGGA----ggggct-ggggctgcggttcagcg

ggtggagagcttgccta---ctagtgtgggtgaggctctgagtctga-gc

ccag-acaccgaagaaactgaaggtggtggga------------------

--------------------------------------------------

------caggagggtcggaagttccgggtcattctcagctccacagctgg

ttcaaggcccgcctgg----------------------------------

-AGACTCGGG---CAGGAA-------------------------------

--------------------------------------------------

----------------TGTG--CACCACACGCTCATAT------------

-CGG--TGC---TCATTTTCAG--AGCCCTTGGTCAACAACTGGGCC

>Cc

GGGACAGCTGTCTTGGAGGCCCTAGGCAGTGGGGAGTTTGTCAAGTGCCT

CCACTCTGTGGGGTGCCCTCTTCCCTTAAAAA--GTAAGTGTGCTCTTTC

C---AAATCAAAAGTCTAAGTGG---agggct-gggggtgtggctcggcg

ggtgaagtgcttgcctagcacgcacgcacgcacgaggcctgagctcgatc

ccag-acaccaggtaaaccgaacctggagagagaggcccgatcaccccca

gcattcagggggtggagt--------------------------------

--------------------------------------------------

------cgggaggaccagacgttccatgccgttctcggctccacagctgg

ttccgggccagccctg----------------------------------

-AGACCTGAG---CAGCAG-------------------------------

--------------------------------------------------

-----------------CGCCCACCCGTGCACTCAC----------GGGT

GCTTGTTTTTTTTTTTTTTCAG--AGCCTCTGGTCAACAACTGGCCC

>Oz

GGGACATCCGTGCTGGAGGCCCTGGGCAACGGGGAGTTCATCAAGTGCCT

CCACTCAGTGGGGTGCCCTCTTCCCTTAAAAA--GTAAGTATGTTCTTTC

C---AAATCAAAAGTAAATGGA----ggggcc-agggatgtggttcagca

ggtagagtgcttgcctg------gcatgcgtgaggcccgagttcgatccc

agac-ac--caaataaactgaatgtggggagacgggcc-aatcatccc-a

gcattcaggaggtagtgt--------------------------------

--------------------------------------------------

------caagagggtcagaagttctagg-ccgtccttactccacagctgg

ttcaaggccagcctgg----------------------------------

-GCACCCGGG---CAGGGA-------------------------------

--------------------------------------------------

--------------------CGCCTGTCATACCCTAA-------------

-TGTGGCGT---TTGTTTTCAG--AGCCTTTGATCAACAACTGGGCC

>Se

GGGACACCTGTGCTGGAGGCCCTGGGCGACAAGGAGTTTATCAAGGGCCT

CCACTCTGTGGGGTGTCCTCTGCCCTTAAAAA--GTAAGCCCATCCTTTC

C---AAATCTAAAGAGAATGGA----ggggtt-gggactgtggctcagct

gatagggtgcttgcata------gcatacaggaggccctgggtttgatcc

ccagcaccacaaaga-gctggt-atg--atggtgcatgtctgccatccca

gcattggggatgtagaac---caggaggatcagatgttcaaggtcatcct

---gtctgccatcccagcattggggatgtagaac---caggaggatcaga

tgttcaaggtcatcct-gtctgccatcccagctttggggatgtagaacca

ggaggatcagatgttcaaggtcatccccagctctctagtgagattaagac

cagcctgggctgcatg----------------------------------

-AGACCTAAG---CACGGA-------------------------------

--------------------------------------------------

----------------CATG--TATCACACACTCA---------------

-CGTGCTGC---TTGTTCACAG--AGCCCTTAGTCAACAACTGGGCC

>Jj

GGCACAGCTGTGCTCGAGGCTCTGGGCGATGGGGAGTTCATCAAATGCCT

CCACTCTGTGGGGTGCCCCCTGCCTTTAAAAA--GTAAGTACATTGTTTC

C---AAACCAGCAGTGAATGGA----gggct---ggggtgtggctcgtgg

gctagagtgtgtgtcta------gcatgtatgagagcctgggttcgatcc

ctagcacctcataag-----aggggcgtggtggtgcatgatatcacccta

gtattcaagagttagaag--------------------------------

--------------------------------------------------

------caggaggaccagaagttccaggtcatcctagagt-atacagtaa

atttgaggcaagcctgagctacgtgagatcctgtctc-------------

-CCCCCGCCC---CACCAA---AAAAAAGATGGATAGAATGGAAAGTTGA

ATGGGAAAATGCAGGCAAG-------------------------------

-ATTCCTGAGCAGGAGCGTG--CATGGCTCACTCATAT----------GG

GCTGGATGC---TTGTTTACAG--AGCCCTTAGTCAACAACTGG---

>Pca

GGCACGCACGTGCTGGAGGCCTTGGGGGACGGGGAGTTCATCAAGTGCCT

CCACTCCGTCGGGTGCCCTTTGCCTTTGAAAA--GTAAGCGCATTGTTCA

A-------------------------------------------------

--------------------------------------------------

-AA-TCAAACGTGAATGAA---ACAGGGCGCCTCAC-CGTAAACCTCAGG

CTTGAGCATGGGA-------------------------------------

-ATCCCCAGGCAGGTGCATT---CGGGGAACCTAA-GG----------GG

GCTGGCTCC---TTGTTTACAG--AGCCCTTGGTCAACAACTGGGCT

>Asp

GGCACATCTGCCCTGGAGGCTCTGGGGGACGGCGAGTTTATCAAGTGCCT

CCATTCCGTCGGGTGCCCTTTGCCCTTAAAAA--GTAAGCGCATCATTTT

A-------------------------------------------------

--------------------------------------------------

-AAGTCAAAAGTGAAGGAG---ACAGTGAGCTTAAC-CATAAACCTCAGG

CTTGGGCGTGGGG-------------------------------------

-ATCCCCGAGCAAG-GACA--TGCACAGAACCTAACAG----------GG

GTGGGGTGC---TTGTTCACAG--AGCCTTTGGTCAACAACTGGGCC

>Cf

GGTGCGGCCGTGCTGGAGGCCCTGGGCGACGCGGAGTTCACCAAGTGTCT

GCACTCCGTGGGGTGCCCTCTGCCTTTAAGAA--GTAAGCGTATTATTTC

AA------------------------------------------------

--------------------------------------------------

-AAGCCAGACGTTCATGAA---ACAGTAAGCT--------GGACGCTAAG

CTTCGGGCTTGTG-------------------------------------

----CCCAGG-AATCCCTG--AGCAGGGACACTCATGT-----------G

GCCGGGTGC---TTGTTCACAG--AGCCTTTGGTCAACAATTGGGCT

>Cgu

GGCACATCTGTCCTTCAGGCCCTGGGTGACGGGGAGTTTATCAAGTGCCT

CCATTCTGTGGGTTGCCCTCTTCCTTTAAAAA--GTAAGTGAATTATGTC

C-------------------------------------------------

--------------------------------------------------

-AAGTCAAAAGCTAGTTAA---GAAATAAGCT------TGCTCTCTA-AG

TAG-----------------------------------------------

-----------------GAACACGTGAGACTCACTG------------AC

AAGGGTTGCATCCTGCTTACAG--AGCCTCTGGTCAACAACTGGGCG

>La

GGCACACCTGTCCTGCAGGCCCTGGGCGACGGCAAGTTTATCAAGTGCCT

CCATTCTGTGGGCTGCCCTCTGCCTTTAAAAA--GTAAGTACACTAGGGG

C-------------------------------------------------

--------------------------------------------------

tggaggaatagcttagtggttacagcgattgcctagcaagtgcaagacct

gagtttgattccccagcactacataaatcgggtgtgctggtgcatgcctg

taatcccagcactcagaaggctgaggcaagaagattgccttgcgttcaag

gccagcctgggttacaaagtgagctcaagaccagcctggactatagagcg

agaacttgcctcaaaacaaaaGTACTTTAGGTACATTA----TGTCAGAA

TTGAAAGCTGATTAAGAAG---TAAGCTTGTGTGTATGTG----------

--------------------------------------------------

--------TGGGGCTGCCTCCTAAGCAGGGACACGTGTGAC--ACTAACA

TCCTCTGACTTCTG-CTTACAG--AGCCTCTGGTCAACAACTGGGCC

>Cp

GGCACCGCTGTCCTGCAGGCCCTGGGTGATGGGGAGTTTATCAAGTGTCT

CCATTCCGTGGGCTGTCCTTTGCCTTTAAAAA--GTAAGTCAGTTATTGT

A-------------------------------------------------

--------------------------------------------------

-AACTTGAGAGCTAATAAA---GACTTCTA----GATGTGCGTGTGTCTG

CGGGGGGGCTATTTGTGGGTGT----------------------------

--------------CACCCTCTAAGCAGGGACACACATGGCTTACTAACC

TGGCCTGCACCCCG-TTTACAG--AGCCTCTGATCAACAACTGGGCC

>Pcu

GGCACCGCAGTGCTGCAGGCCCTGGGCGACGGGGAGTTCATCAAGTGTCT

CCATTCTGTGGGCTGCCCATTACCTCTAAAAA--GTAAGTGGATTATTGT

C-------------------------------------------------

--------------------------------------------------

-AGCTCATGAGCTAATAAA---GTGAGATTCTGTGTGTGTGTGTGTGTGT

GTGTGTGTGTGTTGGGGGGTGT----------------------------

--------------CATTCTCTGAACAGGGACATGCATGGCTCACTAATG

AGGACTGCTCCCCGATCTACAG--AGCCTCTGGTGAACAACTGGGCC

>Mc

GGGACCGCAGTGCTGCAGGCCCTGGGTGATGGGGAGTTCATCAAGTGTCT

CCATTCTGTGGGCTGCCCATTACCTTTAAAAA--GTAAGTGGATTCTTGT

C-------------------------------------------------

--------------------------------------------------

-AACTCATGAGCTAATAAA---GTGAGTTTCTGTGTGTGTGTGTGTGTGT

GTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTAGTGTGTGTG

TGTTGGGGGGATGTCATTCTCTGAACAGGGACATGCACGGCTTGCTAATG

AGGACTGCTCCCCTGTCTACAG--AGCCTCTGGTGAACAACTGGGCC

>Dp

GGCACCGCTGTCCTGCAGGCGCTGGGTGACGGGGAGTTTATCAAGTGTCT

CCATTCCGTGGGCTGCCCTTTACCTTTAAAAA--GTAAGTCAGTTATTGT

A-------------------------------------------------

--------------------------------------------------

-AACCCCAGAACTAATAAA---GATGTGTGTGTGTGTGTGTGTGTGTGTG

GTGTGTGGGTGGGTGT----------------------------------

--------------CACCCCCTAAGCAGGGACACGCGTGG-TCACTAACC

AGGACTGCACCCCTGTTTACAG--AGCCTCTGGTCAACAACTGGCCC

>Cop

GGCACCGCTGTCCTGCAGGCCCTGGGTGATGGGGAGTTCATCAAGTGTCT

CCATTCTGTGGGCTGCCCTTTACCTTTAAAAA--GTAAGTGCATTATTGT

A-------------------------------------------------

--------------------------------------------------

-AACTCAAGAGCTAATAAA---GAAAGCTTCTGTGTGTCAGGGGTGTGTG

T-------------------------------------------------

--------------CATACTCTAAGCAGGGACATGCTTGGCTCACTAACG

AGGGCTGCACCCCTATTTACAG--AGCCTCTGGTCAACAACTGGCCC

>Sv

GGCACCCGCGTCCTGGAGGCCCTGGGCGACGGCGAGTTCATCAAGTGCCT

CCACTCTGTGGGGTGCCCCCTGCCTCTGAAAA--GTAAGCGTGTCCTTTC

A-------------------------------------------------

--------------------------------------------------

-GAATTGAGAGTCGATAAA-----------AAGCAAGCGCATGTACTGAG

CGTGTGCGTGGG--------------------------------------

-------------------------------CTGACGC------------

GGCC-GTGC--CCTGCTTACAG--AGCCTTTGGTCAACAACTGGGCC

>Mma

GGCACGCCTGTCCTTGAGGCCCTGGGCGACGGGGAGTTCATCAAGTGTCT

CCATTCCGTGGGGTGTCCCCTGCCTCTCAAAA--GTAAGCATGCCACTTC

A-------------------------------------------------

--------------------------------------------------

-GAATTGAGAGTTGATAAA-------------------------------

--------------------------------------------------

----------------AAGTAAGCTCCTGCGCTCCGCACATTCACACACT

GACGCGGCTGCGCCTGTTGCAG--AGCCTCTGGTCAACAACTGGGCC

>Oc-TDB

GGGACGGCCGTCCTGGAGGCCCTGGGGGACGGGGAGTTTGTCAAATGCCT

GCATTCCGTGGGGTGCCCGCTGCCTCTGAGCA--GTAAGTACATGCCTTC

A-------------------------------------------------

--------------------------------------------------

-AGACCCCAAAGGCTCCAA----TCAAACATTCTACTCCAACATACACCC

TGGGGCCTGTGCCGCAGAGGGC----------------------------

-GCCCTGGGCAGGGCTGGGGCACG-------CTCACA-------------

GGCCACGTC--CTTGTCCACAG--AGTCCCTGGTCACA--CTGGGC-

Locus 77-12

>ID4

--------------------------------------------------

-----------------------------------------ggggctggg

gatgta--gctcagtggtagagcg-cttgcctagcatg-cg--------c

gaggccctgg-gttcgatccccagcaccgcaaaaaaa-------------

--------------------------------------------------

--------------------------

>Mm

CATTCCCCCACCATGAA--GTAAGT-GCACCAGTGGGGAAGTTATTAGCG

GGCTGGCTGGGGCCGGGCAC-TTG-------AGTTGGGGTTATTT-GGAT

TTGGGAAAAGGATGCTTGTGGCCACAA-----------------------

--------------------------------------------------

---------------CCATAGAGACA---GGAATTCTT----ggactggt

gatata--gctcggtggtagagcg-ctttctcagtatg-tgagtatgtgc

aaggacccggcgttcaatcaccaactccgaaaaaaaaaatggaaaagaca

---------------------GGAATTCTT---GACAGAGTAGA------

-AGTAGGTGTGAGTCATT---ACGTGCCCACTTCTCCCCCAG--TTTGTG

GCCCTAATAGGTGCCCTCCTTGCCAT

>Rn

CATTCCCCCACCATGAA--GTAAGT-GCATTAGTGGGGAT----------

GATCGGCTGGGGCTGGGCAC-TTG-------AGTTTGGGTTATTT-GGAT

TTGGGAAAAGGATGCTTGTGACCCCAA-----------------------

--------------------------------------------------

---------------CTGTAGCGACA---GGAATTCTT----ggactggt

ga---------------cagagta-cttccctagtatg-gg--------c

aatgcctcag-gttcaatccccaacttggaaagaaaaaaaaaaag-----

---------------------GGAATTCTT---GAAAGA-----------

--------CCTAGTCATG---ACTTGCCTGCTTCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCTAT

>Mu

CATTCCCCCACCATGAA--GTAAGT-GCATTAGTGGGGCT----------

GGTTGGATGGG--------------------AGTTGGTGTTATTT-GGAT

TTGGGAAGAGGGTGCTTGTGGACCCAA-----------------------

--------------------------------------------------

---------------CTGTAGATCCA---GGAATTCTT----ggactggt

gataa-tagctcagtggtagaata-cttcccta-tat-tcg--------a

aaggccccgg-gttcaatccctagctccaaaagaaaaagacagggaaaga

aaaaagtggaaaaagaca---GGAATTCTT---AAAAG-GCGGAAT-AG-

GAGTAGGCTTGAGTCATG---ACTTGCCCGAGCCT-CCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Cgri

CATTCCCCCACCATGAA--GTAAGT-GCATTAGTGGGAAC----------

GGTTGGCTGGGGTCGGGGAC-TTGCTT---GAGTTGGGGTTATTT-GGA-

TTGGGCAGAGGGTGCTTGTGGGCCCAA-----------------------

--------------------------------------------------

---------------CTCTAGAGACA---GGAGTACTT----ggattggt

gatatataactcagtgatagagc--ct-ccctagtat--gc-------cc

aaagccacgg-gttcaatcctcaactccaaaataaaaagatgggaaaagg

gaaacataggaggca------GGAATTCTT---GAAAG-GCAGACT-AGT

AAGTAGGCTTGAGACGTA---ACTTGCCTGAGCCTTCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Se

CATTCCCCCACCATGAA--GTAAGT-GGATTACTGGGGAT----------

GGTTGGCTGGGGCTGGGAAGGTACTTGAGAGAGTTGGGGTTATTT-GGAT

TTATGAGGAGGGGGCTGG-GGACCCAA-----------------------

--------------------------------------------------

---------------CTGAAAAGGCA---CGAATTCTT----ggactacg

gatg--tagctcagtttttagagtgcttctttaatatgtgc---------

aagaccctgg-gttcaatccctaactccaaaacggaaaagaataaaattg

aaatga---------------GGGATTCTT---GGAAG-GTGGAGT-GG-

GAGTGGGCTTGAGTCATG---ACTTTCCCGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Jj

CATTCCCCCACCATGAA--GTAAGT-GGATTAGTGGGGGGC---------

GGTTGGCTTGGGTCTGGGGA-----------------GGTGATT--GGAC

TTGGGAAGAGGG-GCTGT-GAACCCAA-----------------------

--------------------------------------------------

---------------CTGAAAACACA---GGAAT--------gg-----g

gatg--tagctcagtggtt-gagtgcttacctaa---------------c

aaagtcctag-gtttgatccttcaacccccaaaacacaaaggaaaaagca

---------------------GGAATTCTT---GAAAG-GTGGAAT-GGG

AGT-AAGCTTGAGTT-TG---ACCT-CTGGAGCCT-CCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Pc

CATTCCCCCACCATGAA--GTAAGT-GGGTTGTTGGGGGA----------

GGTTGTCTGGGTCTTGGGAAGTACCTGAGAGAATTGGGGTTATTT-GGAC

TTGGCAGGAGGG-GCTGA-GGATTGTA-----------------------

--------------------------------------------------

---------------CTGAAAAGACA------------------------

--------------------------------------------------

---------------------GGAATTCTT---GAAAG-GTGGTAT-GGG

AGC-AGTCTTGAGTCATG---ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Asp

CGTTCCCCCACCATGAA--GTAAGT-GGGTTAGTAGGGGA----------

GGTT-ACTGGGGCCTGGGAAGTACCTGAGAGAATTGGGGTTATTT-GGAC

TTGGGAGGAGGG-GCTGA-GGATGGAA-----------------------

--------------------------------------------------

---------------CTGAAAAGATG------------------------

--------------------------------------------------

---------------------GGAATTCTT---GAAAG-GGGGAAT-GGG

AGG-AAGCTTGAGTCATG---ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Cf

CATTCCCCCACCATGAA--GTAAGT-GAGTTAGTGGGGAC----------

TCTTGGCCGGG------------GCTTGG-GAGTTGGGGTTATTTTGGAT

TTGGGAGGAAG--GCTGACGGCTATAT-----------------------

--------------------------------------------------

----------------TGAAAAGACA------------------------

--------------------------------------------------

---------------------GGAATTCTT---GGAAG-GTGGACT----

GGGTAGGCTTGAGTGGTG---ACCTGCCTGAGCCTCCCCCAG--TTTGTG

GCCCTTATAGGTGCTCTCCTTGCCAT

>Hg

CATTTCCCCACCATGAA--GTAAGT-G-----------------------

CATTGGCTGCGGCTTGGGGGGTACCCGAGAG-----------------AC

TTGGGAGAAGGG-GCTGAAGGCGGTA------------------------

--------------------------------------------------

---------------CTGAAAAGA--------------------------

--------------------------------------------------

---------------------GCAACTCT----GGAGAGGTGGAATGGGG

GAGTGGGCTAGAATCATG---ACCTGCCAGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Cgu

CGTTCCCGCACCATGAA--GTAAGT-GGGTTCAGGACAAC----------

GGTGGGCTGGGGCCTCGGGGGTTCCAGAGAGTGGGGGGGTTACTT-GAAT

GGGGGTCGGGGAGGAGGGCCTACGGAAAGTG-------------------

--------------------------------------------------

---------------CTGGAAAGAAG------------------------

--------------------------------------------------

---------------------GGAAT-CTT---GAAAG-GTGGACC-GGG

AGT-AGGCTTGAGTTGTG---ACCTGCCCAAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCTCTCCTTGCCAT

>La

CATTCCCCCACCATGAA--GTAAGT-GGGTTCATGAGGAC----------

AGTCGGCTGGGGCCTCAGGTGTACCAGAAGTTGGGG---TTGTTT-GACC

TGGGAGTTGGGGGAAGGGGCTGAGAAACAAT-------------------

--------------------------------------------------

----------------TGAAAAGAAA------------------------

--------------------------------------------------

---------------------GGAGTGATT---GAAAG-GTTGAGT-GGG

AGT-AGGCTTGAGT-GTG---ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Ts

CATTCCCCCACCACGAA--GTAAGT-GGGTTAGTAGGGA----------T

AGCTGCCGGGGGCCTGGGGGG-TCCAGGGAGAACTGGGGTTGTTT-GGAC

TGGGG------AGGAAGGGCGGCGGATCGAG-------------------

--------------------------------------------------

---------------TAGAAGAGACG------------------------

--------------------------------------------------

---------------------GACATTCTT----AAAG-GTCGAAT-GGG

AGT-TAACTTGAGTTGTG---ACCAGCCTGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCTAT

>Mc

CCTTCCCCCACCACGAA--GTAAGT-GGGT-AGTGAGTGG----------

---GGCCAGTTGCCTAGGGTC----TGAGAGGGATGGGATTGTTT-GAAT

TTGGG-AGGAGGGGCTGA-GGACCTAG-----------------------

--------------------------------------------------

---------------TGGAAAAGACA------------------------

--------------------------------------------------

---------------------GAAATTCTT---GAAAG-ATTGAAT-GGC

AGT-AAGCT-GAGTCATG---ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTCGCCAT

>Cp-TDB

CTTTCCCCCACCATGAA--GTAAGT-GGGTTCGTGGGGGC----------

GGTTGCCTGGGGCCTGGGAGGTTCCCGAGAGAGTTGGGGTTGTGT-GGAT

TTGAGGAGGAGGGACTGA-GGACCTAG-----------------------

--------------------------------------------------

---------------TGGAAAAGACA------------------------

--------------------------------------------------

---------------------GAAATTTTT---GAAAG-CTTGAAT-GGC

AGT-AGGCTTGAGTCATG---ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTCATAGGTGCCCTTCTTGCCAT

>Dp

CCTTCCCCCACCATGAA--GTAAGT-GGGTTAGCGGGGGT----------

GGTTGCCTGGGGCCTGGGAGGTTCCCGAGAGAATTGGGGTTGTTT-GGAT

TTGAG-AGGAGGGGCTGA-GGACCTAG-----------------------

--------------------------------------------------

---------------TGGAAAAGACA------------------------

--------------------------------------------------

---------------------GAAATTCTT---GAAAG-GTTGAAT-GGC

AGT-AGGCTGGAGTCATG---ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTCATAGGTGCCCTCCTTGCCAT

>Cop

CCTTCCCCCACCATGAA--GTAAGT-GGGTTAGTGGGGGC----------

GGTTGCCTGGGGCCTGGGAGGTACCAGAAAGGGTTGGGGTTGTTT-GGAC

TTGGG-AGGAGG---------ACCAAG-----------------------

--------------------------------------------------

---------------CGGAAAAGACA------------------------

--------------------------------------------------

---------------------GAAATTCTT---GAAAG-GTTGAAT-GGC

AGT-GGGCTTGAGTCGTG---ACCTGCCTGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTTCTTGCCAT

>Sv

CATTTCCCCATCATGAA--GTAAGT-GAGTTAGTGGGGGTC---------

-TTTGGCTGGAACCTGGGAGG----TGAAAGAGTTGGGGTTATTT-GGAC

TTGGGGAAG-GGGGCTGAGTAACGAAC-----------------------

--------------------------------------------------

----------------TGAAAAAACG------------------------

--------------------------------------------------

---------------------GGAATTCTT---GGAAA-GAGGAAT-GAG

AGT-AGTATTAAATTATA---ACGTGCCTGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTTCTTGCCAT

>Mar

CATTCCCCCATCATGAA--GTAAGT-GAGTTAATGGGAGTC---------

-ACTGGCTGGAGCCTGGGAGG----TGAAAGAGTTGGGGTTATTT-GGAC

TGGGGTAAG-GGGGCTGAGGAACGAAC-----------------------

--------------------------------------------------

----------------TGAAAAGATG------------------------

--------------------------------------------------

---------------------GGACTTCTT-------GTTAGGAGG-GCG

GAT-AGTGTTGCATTATA---ACATTTCTGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTTCTTGCCAT

>Gg

CATTCCCCCACCATGAA--GTAAGTGGGCT-----GGGGCC---------

---TGGGAGATACC-----------TGAGAGACTTGGG-ATATTT-GGGC

ATGGGGGAGGGGCTGAGGAAGGAGCCG-----TCTGGATGGG---AATTC

TTTTTTTTTTTTTAAATTAAAATATATTTATTTATTTATTTTTAACTTTT

TATGTTCATTTATTGGTGCATTGTAAATTATAATTATACATTTTGATATA

TGTCAGGGTATGAACATCATACATGCACACATTGCACATTTAGCCCTCCC

TCCAATCCCACCC---TATTTGGATG------------------------

--------------------------------------------------

---------------------GGAATTCTT---GAAAG-GAAGAAT-GGG

AGT-AGGAAGAATGAGTCGTGACCTGCCTGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

>Oc-TDB

CATTTCCTCACCACGAA--GTAAGT-GGCTCAGTGGAGGTC-CGGTTGGA

GGGGGGCTGGCACCTGGGA---ACCCGAGAGAGCTGATTTTTGT--GGGC

GGCGGCCGGGG-TTCTCGGAGGTGGAG-----------------------

--------------------------------------------------

--------------TGGGAGAAGGCT------------------------

--------------------------------------------------

---------------------GGAGCCGTG--------------------

---------------------ACCTGCCCGAGCCTCCCCCAG--TTTGTG

GCCCTGATAGGTGCCCTCCTTGCCAT

Locus 437-13

>B1F2

--------------------------------------------------

--agccgggcgtggtg--g--cacacgcctgt-aatcccagca-ctcggg

aggcagaggcaggaggatctccgtgagttcgaggccagcctggtctacat

agcgagttccaggcc-agccagggctacatagtgagaccctgtctcaaaa

aaacaaaa------------------------------------------

--------------------------------------------------

--------------------------------------------

>ID4

--------------------------------------------------

------ggggctggggatgtagctcagtggtagagcgcttgcctagcatg

cgcga-ggccctgggttcgatcccc-agcaccgcaaaaaaa---------

--------------------------------------------------

--------------------------------------------

>PB1D10

--------------------------------------------------

agccgggcgtggtggcgcacgcctgtaatcccagcactcgggaggctgag

gcaggaggatc---gtgagttcaaggccagcctgggctacatagcaagac

cctgt--ctcaaaaaaacaaaa----------------------------

--------------------------------------------------

--------------------------------------------

>PB1D10

--------------------------------------------------

-------------------------------------------------a

gc-cgggcgtggtggcgcacgcctgtaatcccagcactcgggaggctgag

g---caggaggatcgtgagttcaaggccagcctgggctacata-------

------------------------------gcaagaccctgtctcaaaaa

aacaaaa-------------------------------------------

--------------------------------------------------

--------------------------------------------

>ID4

--------------------------------------------------

------------------ttttttt-gcggtgctgaggatcgaacccagg

gcctcgcgcttgctaggcaagcgctc-taccactgagctacatccccagc

ccc-----------------------------------------------

--------------------------------------------------

--------------------------------------------

>PB1

--------------------------------------------------

-------------------------------------tgttttgtttt--

----gagacagggtcttgctatgtt-gcccaggctggcctcgaactcctg

gactcaagtgatcctcctgcctcagcctcccgagtagctgggactacagg

cgtgcgccaccgcgcccggct-----------------------------

--------------------------------------------------

--------------------------------------------

>Mm

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAT

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CCT--------ACTGCTTTTGTGTCTCCCTCT-----TCTACATTTTCTG

TTTATCCTTTGTGTAGTAGTTTGG--------TCTCTCCTTCCCACATCC

TACCTTTTTT---------GGGTATAAA-TAGACATTGAGAGAACATGAA

TAGACATTGTGTGAACATTAATGGTA-TATCTATAA------------GA

TTTCAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CCACTG-CTT

T-GCAGACAACTCCTAAAAGTGATTGCTT---------------------

------cggcaaggtgtggtacat---------aatcccagca-cctgag

agg-agaggcagcaggatgt---tgacttcgaggccatcctgtgcaacat

agctacttcaaagtc-agtctgttgtacataatgagaagctgtctca---

-------------AAAAAGGTACCATTTT---GATCTGGAAATATG----

--------------------------------------------------

---TTATTTGTTCAAT-TTGTATTTTCCAAACAATGATCAATTAAGGGGC

AAACCTAGACATTA-GTTTTGGTTAT-TTAGGCCAAAATTATC-------

--------------------------------------------------

----------AGCC----CTTTTT--------------------------

--------------------------------------------------

--------CTAAAATTATATTCTA-----------CTACTACTACTTGTG

ATGAGTCATTTGAGAAGATAA---TTCAGAAAACC---------------

--------------------------------------------------

------------------------------------------------AC

AAATTCTGTCA----TATTTA-----------------GGATGAGTCATT

AGACAAAGATGATTCTAGAAAATTTCTC----------------------

--------------------------------------------------

------------------------CATAGCCAGCTTTTT---CGAGATAG

ATTCCTT-GTTAGATGCT--------------------------------

--------------------------------------------------

--------GTTTACCTGTGCTT-AGTAGCTGCGTGAGTAACATAC-----

------------------------TGTATTTTGCTTAACAAGATAAATCA

G--ATTGTTTCTGCTTATCGCTTCAACTAGAAGTATTACATTCC

>Rn

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGCT

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT-GGACTGTAAGGATTTTATGTCTCCCTCTTT-CTTCTACACTTTCTG

TTTATCCTTTGTGTAGTAGTCTAG--------CCTCTCCTTCCCATATCC

TCCCTTTTTT---------GGGTATAAA-TGGGCATAGTGAGTCAGCCAT

TC-------TGTGAACATTAATGATA-CATCTGTAA--------GATATA

TTTCAAATCTTA--------------------------------------

--------------------------------------------------

----------------------------------------CCACTG-CTT

T-GCAGGCAACTCCTAGAAGTGATTGCTT-----AGAAGTAGCACTGCTT

---gctcagcaaggt--ggtaggt--gcctgt-gatcccagcc-cctgag

agg-agaggctgcaggggga------cttagagaccatccttggccaagt

ggttagttcaaagtc-agtctgttttacataatgagaacctgtctcaa--

-------------GAAAAGGTGCCATTTT---GATCTGAAAATGTA----

--------------------------------------------------

---TTATTTGCTCAAT-TTGTATTTTCTAAACAATAATCAGTTAAGGGGC

AAACCTAGACCTTA-GTTTTGTTTAT-TTAGGCCAAAATTATT-------

--------------------------------------------------

----------ATCC---TCTTTT---------------------------

--------------------------------------------------

--------CTAAAATTATATTCTA-----------CTACTACTTATGATG

A---GTCATTTGAGAATGTAA---TTCAGAAAACC---------------

--------------------------------------------------

------------------------------------------------AC

AAATT--GTCA----TATTTA-----------------GGATGAGTTATT

ATATAAAAATGATTCTAGAAAATTTCTC----------------------

--------------------------------------------------

------------------------CATAGCCAGCTTTTT---TGGAATAG

ATTCCTT-GTTAGATGAA--------------------------------

--------------------------------------------------

--------GTTTACCTGTGCTT-ATTAGCTGCTTGAATAACGTGTTG---

-------------------------TATTTT-GCTTAACAAGATAAATCA

G--ATTGTTTCTGCTTATCACTTCAATTAGAAGTCTTACATTCC

>Mu

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT-GTACTGTAAGGATTTTGTGTCTCCCTCTTTTCT-CTACATTTCCTA

TTTATCCTTCGTCCTGAAGTGTGGTAATCTGGCCTGTCCTTCCCACACCC

AACCCTTTTG---------GGGTAGAAA-TGGACACGGAGAACCACCCAG

CC---------TGAACATTAATGATA-CAGCTATAA--------GATAGA

TTTCAAGTTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CCACTGAATT

T-GCAAGCAACTCCTCAA-GCGATTACTT-----AAAAATAGCACTGTTT

---tctgggtaaggt-gggtacat--gcctgc-aatcccagca-cctgag

agccaggtgaggcgcaagat-gttgcttttgaggccagcctggactacat

agctaattcagtctgtagtacat-------aatgagaacctgtctcca--

-------------AAAAGGGGGTT------------GAAAAATGTA----

--------------------------------------------------

---TTATCTGATCAAT-TTGTATTTTCCGAACAATGATGAATTAAGGGAC

AGGCCTGGACCCCA-GTTTTGTTTAT-TTAGGCCAAAATCATC-------

--------------------------------------------------

----------AG------CTGTTTTT------------------------

--------------------------------------------------

--------CTAAAATTATGCCACA----TGCTCCACTACTTCATATGATG

A---GTCATTTGGAAATATAA---TTCAGA--------------------

--------------------------------------------------

---TTTTGTCA----TATTGA-----------------GGATGAGTCATT

AGACAAAGATGATTCTAGAGGATTTCTT----------------------

--------------------------------------------------

------------------------CATAGCCAGCTTTTT---GGGAATAG

ATTCCTT-GTAAAATGAG--------------------------------

--------------------------------------------------

--------ATTTACCTGTGCTT-ATTAGCTACTTGGTTAAGATACTA---

-------------------------TATTTT-GCTTAACAAGATCAATCA

G--ATTGTTTCTGCTTATCCCTTCAATTAGAAGTGTTGCATTCC

>Cc

TGAGAAACCTCTTCAGGACATGTACAACTGTCTCC--GTATCCTTCAGAA

-TTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

GATTGTAGTGTAAGGATTT-GTGTTTCCCTCTTTCC-ATTATATTTTCTG

TTTATCCTTTGTCCTGAAATGTAGTAGTCTGGCCTCTCTTTCCACCTC--

------TTTT---------GGGTAGAAA-TAGACATGCAAAACCAGTCAA

TG---------TGAACATTAATGATA-CATGTATAA-----TAAGACAGG

TTTTAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CTACTGACTT

T-ACAGGCAACTCCTAAAAGTGATTACTT-----TGAAATAGTATTGTTT

---gctgggcaaggt--tgtacat--acctat-aattccagca-tctgag

aggcaacgctgtgtagt---------------------------------

---tagtaggaaagccagcttgtattacataatgagaacctgtttcaa--

-------------AAA--GGTACTATTTT---GGTCTGAAAATGTA----

--------------------------------------------------

---TTGATCAAT-----TTGTATTTTCTAAACAGTAATGAATAAAGGGAT

AAACCTGGACCT-A-GTTTTGTTTAT-TTAGGTCAAAATTATC-------

--------------------------------------------------

----------AAC----TCTTTTT--------------------------

--------------------------------------------------

--------CTAAAATTATGTCATA------TT--ACTACTTCTTATGAAT

T---GTCATTTGAGAATATAA-CTTTAGAAAATGA---------------

--------------------------------------------------

------------------------------------------------CA

CA-TTTTGTCT----TATTTA-----------------GGATGAGTCATT

AGACAAAGATGATTCCAAAAA-TTTCTT----------------------

--------------------------------------------------

------------------------CATTGCCAGCTTTTT---GGGCATAG

ATTCCTT-GTTAGATGGC--------------------------------

--------------------------------------------------

--------ATTTGACTGTGCAT-ATTGGCTGCTAATATAACATGTTATAT

-------------------------TGGATTTGCTTAAC---ATAAATCA

G--ATTGTTTCTGCTTATCACTTCAATTAGAAGTGCTACATTCC

>Oz

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT-GTACTGTAAGGATTTTGTGTCTTCCTCTTTCC-TCTACATTTTCTG

TTTATCTTTTGTCCTGAAGTGTAGTAATCTGATCTCTCCTTCCCATA-CC

TCATCTCTTTT--------GAATAGAAA-TAATCATGGAGAACCAGCCAG

TA---------TGAACAGTAATGATA-TATCTATAATATAATAAGACTGA

TATCAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CCACCAACTT

T-GCAGGCAACTCCTAAAAGTGATTACTT-----AGAAATAGTATTATTT

---gctgggcaagttgg--tacat--gcctat-aatccccgca-tctgag

aggcaaggctctgtagc---------------------------------

---tagttcaaagcc-agcctgcattacataatgagaacctgtctcaa--

-------------AAAGAGGTACCATTTT---GGT-GACAA-TGTA----

--------------------------------------------------

---TTATTTGATCAAT-TTGTATTTTCTAAATAATGATGAATTAAGGGAT

AAACCTGGACCT-A-GTTTTGTTTAT-TTAGGCCAAAATTGTC-------

--------------------------------------------------

----------AAC-----CTTTTTT-------------------------

--------------------------------------------------

--------CTAAAATTATGCCAAA----TATTTTACTACTTCTAATGATT

T---TTCATTTGAGAATATAA--TTTCAGGCAACC---------------

--------------------------------------------------

------------------------------------------------AC

AGGTTTTGTCT----TATTTA-----------------GGACAAGTCATT

AGACAAAGATGATTCCAAAAACTTCCTT----------------------

--------------------------------------------------

------------------------CATTTCTAGCTTTTT---GGGCATAG

ATTCCTT-GTTAGATCAC--------------------------------

--------------------------------------------------

--------ATTTGCCTGTGATT-ATTGGCTGCTTGAATAGCATATTATAT

-------------------------TTGATTTGCTTAACATGATAAATCA

G--ATTGTTTCTGCTTATCTCTTCAATTAGAAGTGTTACATTCC

>Se

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

ATTTTGTTTGTTA---ttttttttttgagaaagggtctcattgtatagcc

caggctggccttgaactcacagagatcctcctgcctctgcctcccaagtg

ctgggggttaaaggaatgtgccactacactgggct---TGAAATTTGAGA

GTT-AAATTGTAAGGATTTTATGTCTCCCTGTCTTT-ACTACATTT-CCA

TTTATCCTTTGTCTTG-----TATTAGCCTAACCTCTCCT-CATGTC-CC

ACCTACTTA----------GGGCAGAAA---TTGGATAGGAACCAGCCAG

TG---------TGAATAATAATGGTAACATCTGTAA-----TAAGACGGA

TTTTGCATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CCGTTGACTT

T-GCAGGCAACCTCCCAAAGTAATTACTT-----ATAAATAGTATTTTTT

---tctgggcaatagtg----------cctgt-aa-ccctagtacctggg

agatcaaggcagcagtact----tgtgtttgaggccagcctggactacat

aattagttcaaggct-agcttgctct----aatgagaccatgtctcaaaa

gaaaaa-------AAAGG--------------------------------

------ggggctggagagatgacttactagttaagagcactggctgctct

tgtagaggacccaggctcagttcctggttcctagttcccagcacactcat

ggcagctaacaactgtcagaaactccagttccaggggttccaacaccatc

ttctggcctccacaggcagtgtgcaacatgggtacacttacatgcaggca

aaacacataaaataaaaataa---TTTTTAAAAA---------TGTATGA

AAAAGAAAGTACTATTTTAGGGAAAATGTATTAT----------------

---TTGGTCTAT-----CTGTATTTTCTAAACTATGACAACTTAAGGGA-

CAGCCTGGGCCTTA-GTTTTGATGATTTTAG-CCAAAATTATT-------

--------------------------------------------------

----------GTCAA---TTTTTTTT------------------------

--------------------------------------------------

--------CTAAAATTATGCCACA-------CATTTTACTACTTACAATG

A---GTCATTTGAGAAAATGA-CTT-CAGAAAACC---------------

--------------------------------------------------

------------------------------------------------AC

AAATTTTGTCA----TTTTTA---------------AAGGATGAGTCTTT

AAACAAAT---ATTCCAGAAAATTCTTT----------------------

--------------------------------------------------

------------------------ATAGCTAGCCTTTT---GGGGGGATC

ATTCTGT-GTTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTGCCTGTGCTTGATTTGTTGCTTGAATAACATACTATGC

-------------------------TGTATTTGCTTAACAAGATATATCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

>Jj

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GACA

CCT-GGATTGTAATGATTTTATGTCTCCATTAC----TTTTTTTTTTCCA

TTTATCCTTTGTCCTGTATTTTACTAGCCTAGCCTCTCCACATTAGAAAC

AGGACTGGGGAACA-----GGGTAGAAACAGGACTGAGG-AACCAACCAT

TG---------TGAAGAATAGTGTAAA-CCTGTAA------TAAAACAGA

CTTCAAATTCTA--------------------------------------

--------------------------------------------------

----------------------------------------CCATTGACTT

T-GGAGGCAACCCC-AAATGTAATTAGTT-----AGAAAAGTTACTGTTT

---gctgggtatggtggtgcacac----ttgt-aatcccaaca-cttggg

aggctaaggcagcaggatgg---tgagtttaagtccagcctgg-ctccgt

agttagttcaagctc-agccagcatt----ggtataagcttgccccaaaa

ggggggggg----AA---GGTTCTATTTT---ATGAAGAAAATAATA---

--------------------------------------------------

---TTACTTGTTCAAT-CTATATTTTCCACACT--GATGGATTAAGGAAC

AACC-TAGACCTTACGGTTTGTTGATTTTGG-TCAAAATTAAT-------

--------------------------------------------------

----------ACCAGGCCCTTT----------------------------

--------------------------------------------------

--------CTAAAATTAGTACATA------TTTCACTGCTTCTTAAAATG

A---GTCATTGAAATATGAA----TTAAGGAAGTG---------------

--------------------------------------------------

------------------------------------------------AC

AAATTTTCATCA------------------------GGTGGGGAGGCACA

GACC----TTTAATCCTAGCNNNNNNNNN------gtatcggatccagaa

ttcgtgatttccaggtcagcctgggctagagtgagatcctacatcaaaaa

TCCCAAAGCACAATGATTGAGATGGAGAGGGGATATGATAGAGAATGGAA

TTTCAAAGGTGAAAGTGGGGGGGAGGGTATTACCATGGGATAATTTTTAT

AATCATGGAAAATGTTAATAAAAATAGATAAAAAAAATCCCAAAGCAAAA

AAAAAAAAAAAAAA-GAGAGAGAGAGAGAAAAAGAAGAAAGTGGCAAATT

TTGCCCCTTCTTTTTAAAGGGTTGAGTCATTAGACAAATATGAAAATTTA

CC------------------------------------------------

--------------------------------------------------

------------------------CATAGCTAGCTTTTC---AGGGATAG

AT-CTTTTGTTAAATAAATAAATTTCTTTAAGGTTTtttttttttttttt

tttgaggtaggttctcactctagcccaggctgacctggaattcactatgt

agtctcagattggctttgagctcacaggaatcctcctacatcttctttcc

tagtgctgggattaaaggtgtgcaccaccacgcctggttTAAAAAGTAtt

tttatttacaagcagagaaagagagaagagaaacagacagaatgggtgct

ccagggccaccaaccactgc---aaaaaacctccatatgcatgtgccact

ttgtttcatctgactacatgtgggtactggggaattgaacctgggtcatt

aggttttacaggctggcaccttaaccactgaaaaatccctccagcccTGT

TAAATGATTTTTGCCTGTGCTTGATTGGCTGCTTGAGTAATATATTATAT

-------------------------TGGATTTACTTAACAAACTACATCA

G--ATTCTTTCTGCTTATCACTTCAATTAGAAGTGTTACACTCC

>Pca

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAG

ATTT----------------------------------------------

--------------------------------------------------

--------------GAGACATCTGTTGTAAGGATTTTGTGAGATTTGAGG

CAT-TTATTTTAAGGATTTTGTGTCTCCCTCTCCCATC-TACATTTTCCA

TTTATCCTTTGTCCTGAACTAGAGCACCCTAACCTCTC-TTCCCCTA-CC

TAG-TTT------------GGGTAGAAA-TAGGGCTGGGGAACCAGCCAG

GG---------TGAAGAATAGTGATG-CATCAATAA-----TAAAAGAAA

TTTCAAATTT-A--------------------------------------

--------------------------------------------------

----------------------------------------CCATTGACTT

T-GCAGGCCACTTCAAAAAGTGGTTAGCC-----A---------------

---gctagttgcagtgg--cacat---gctgt-aatcccagcgatttagg

aggtggaggcaggagaatca---caggttcaagaccagaggca---gcct

atatagctt---------------------attaagactctgtctcaaga

taaaaacttt---AAAAA--------------------------------

-------gggctaggggtacagctcagtggtggagctcttgcaaagtgtg

tgtaa-ggtcctgggctcaaaccccaagtaccaaaaaaaaaaaaaaaa--

--------GTGATTAGTTAGAAATA-----GTACTATTTG----------

cttggtgaggtggggtgcatgcctataatcccagcactgaggaaacagag

gcagaaggatc---atgagttcgaggccagcctgagttacatagtgagac

cttat--cca-ggagaaaacaa--GTACCATTTG-----TGGAAACAATA

ATCTTATTTGGTCAATTCTATATTTTCTAAACTACGGTAAATTAAGGGGC

AACCTAGACCTTGT-GGTTTGTTTATGTTGGTTCAAAATTAAA-------

--------------------------------------------------

----------TATAAACCCTTTTT--------------------------

--------------------------------------------------

--------CTAAAATTATGCCACA----AACGTTACCACTTCTTATGATG

A---GCCACTGGAAAAATATG-ATT-CCAGAAAAT---------------

--------------------------------------------------

------------------------------------------------CA

CAGTTTTACCAC---TTTTTA-----------------GGATAAGTCTTC

GGAGAAAT---ATTCCAGAAAATTCCTTT---------------------

--------------------------------------------------

-------------------------ATGGCCAGCTTTTT---GGGAATAG

AT-CATTTGTTAAATGAA--------------------------------

--------------------------------------------------

--------GTGTTC-TGTACTTGATTAACTATTTGAGTAACACATTATTT

-------------------------TAGGTTTACTTAACAAGATCCATCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

>Asp

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

--------------GAGGCATCTGTTGTAAGGATTTTGTGAAATTTGAGG

CAT-CTGTTGTAAGGATTTTGTGTCTCCTTCTCCCTTC-TACATTTTCCA

TTTATCCTTTGTCGTGAACTATAGCAGCCTAGCATCTTCTCAGCCCACCC

CTCCCCAACCACCTATTTTGGGTAGAAAATAGGGCTGGGGAACCAGCCAT

TG---------TGAAGAATAATGATATATCAACGG------AAAAAGAAA

TTTCAAGTTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CCATTGACTT

T-GCAGGCCACCTCAAAAAGTGAT-AGTTG--------------------

---gccaggtgcagtggtatatgc---ctttt-aatcccagcaacttggg

aggcggaggcaagaggatt-gtaa--gttcaagaccagagtcaacagcct

gcgcaactt---------------------agcaagaccctatctcaaaa

taa----------AAAAGA-------------------------------

-------gg-ctgggg-tgcagctcggt---agagcacttgcaaagtatg

ctcaa-gaccctggattcaacctcccagtactgccaaaaaaaaaaaag--

------------AGAGTTAGAAATA-----CTACTATTTG----------

ctgggagaggtgaca--catgcctgtaatcccagcactcaggaggcagag

gcaggaggatc---acgagttcaagggccggctgggttacatagtgagat

cttgtttcagcggggaaaaata--GTTCTATTTG----------------

------ATCAAT-----CTGTATTTTCTAAACTATGATGAATAAAGGGGC

AACCGGTACCTTAT-AGTTTGTTTATATTGTTTCAAAATGAAA-------

--------------------------------------------------

----------CATAAAACCTTTTT--------------------------

--------------------------------------------------

--------CTAAAATTATGCCACA----CATTTTACCACTTCTTATGATG

A---GCTATTGGAAAAATATG-ATTGCAGAAAACC---------------

--------------------------------------------------

------------------------------------------------AC

AAATTTTACCAC---TTTTTA-----------------GGATGAGTCTTT

GGAGAAAT---GTTCCATAAAACTCCTTCATA---ggggctggaggttta

gctcagttggtagagcgcctgcctagcaagcgcaaggccctgggttcgat

cctcagcaccacataaaaacgctgggcgtggtggcgcattcctgtaatcc

cagtgacttgggaggcggagtcaggaggatcacatgagttcaaggccagc

ctggtctacacaacaagttccaggatagcctgagctacacagtgaaatcc

tgtctcaaaaaaaaaaaaaaaaaaagtaaaaaaaaaaa------------

--------------------------------------------------

------------------CTCCTTCATAGCTAGCTTTTT---GGAAATAG

AG-CCTT-GTTAAATGAA--------------------------------

--------------------------------------------------

--------GTGTTCCTGTACTTGATTGGCTGTTTGAGTAGCATGTTATTT

-------------------------TAGATTTACTTAACAAGAT-CATCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

>Cf

TGAGAAACCTCTTCAGGACATGTACAACTGCCTGC--GTATCCTTTGAGA

TGTG----------------------------------------------

--------------------------------------------------

-----TGTTATAAGAATTTTGTGTCTCCCTCTTACCCC-TGCATTTTCCA

TTTATGCTTCATCCTAAACTGTAGCAGCCTAGCCCCTCTTCTCTAATGTC

TGCCTATTTT---------GTGTAGAAA-TAGGGTCAAGGAACCAA-CAG

TG---------TGAAGAATAGTGATAC-ATTTATAG-----TAAAACAAA

ATTCAAATTTTT--------------------------------------

--------------------------------------------------

----------------------------------------ACATTGACTT

T-ACAGGCAACCCCCC---------AGAA---------------TAGTTT

---gcccagtgtggtgacacatgt---ctat--aatcccaga-actcagg

aggctaaggcaggtggata-tga---gttcaaggccaccctgg----gct

acac--------------------------agtaaaaccatgtttcaaa-

-------------AAAA-TGTACTGTTTG---GTGAAAAAATA-GTATTA

TTTCATCAGTCTTGAAAAAATA----------------------------

--------------------------------------------------

------------------------------GTAT----------------

---TTCATCAGT-----CTATATTTTCTAAAATACAGTGAATTAAAGGGC

AATC-TGGACTTGATGGTTTGTTTATATTGGGTCAAAATTAAA-------

--------------------------------------------------

----------TATAAAATCTTTTT-T------------------------

--------------------------------------------------

--------TAAAATTTATCACTTC------------------TTGTGATG

A---GTCATTGGAAAAGTAGG-ATTACAGAAAACC---------------

--------------------------------------------------

------------------------------------------------AC

AAATTTTACCAC---TTTTTA-----------------AGATGAGTCATT

GTAGAAATATGATTCCAGAAAATTATTTT---------------------

--------------------------------------------------

-------------------------GTAGCCAGCTTTTT---CGGAATAG

AT-CCTTTGTTAAATGAA--------------------------------

--------------------------------------------------

--------ATTTGCCTGTACTTGATTAGCCATTGGAGAAACATATCTTAT

-------------------------TAGATTTGCTTAACAAGATGTATCA

G--ATTCTTTCTGCCTATCACTTCAGTTAGAAGTGTTACATTCC

>Hg

TGAGAAACCTCTTCAGGACATGTACAATTGGCTAC--GTATCCTTGTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

TGT-GTATTGTAAGGATTTTATCTTCCTCTTCTTCATTTCCCATTTATCC

TTTGTGGTAATCTCGACTCCCTGTCAGTTTTCA-----------------

-------------------GTAGAAA-TAGGGGTGGAGAACCC-CCACTG

---------TGATGAGAAGTGATAA-ATTAGTAA--------TAAAAAAT

TCCAGTTTTC----------------------------------------

--------------------------------------------------

----------------------------------------CCATTGACTA

G-ACAGACT--CCCAAAAT------ACTATT---TAGAAA---TGGTTTT

-----ccagtgaagtgacacacat---ctat--tattccggg-actcagg

agacttgaggggaaggatcatgaa--tttcaggtagc--ttgg----gct

acat--------------------------agtgggaccctgtctccctc

cccctgcc-----AAAC-AGTACTATTTT---GGGAAAAA-TA-GTACTA

G-------------------------------------------------

--------------------------------------------------

---TTGGGCAAA------TATGTTTTCTAAACTAC--------------C

AACA-TAGGCCTTATGGTTTGTTTACATTGGTTCAAAATTACA-------

--------------------------------------------------

----------TATAAAC-CTTTTTCC------------------------

--------------------------------------------------

--------CTAAAATTATACCACA---AACTTTATCACTTTTTTTTTTTT

TTTTGCCAGT--CCTGGGCTTAGACTCAGGGCCCTGGCTTCCTTTTGCTC

AAGGCTAGCACTCTGCCACT---tgagccacagcgcccactactggcttt

ttctgtgtatgtggtaccgaggaatcgaacctgggtcttcatgcatgcta

ggcaagcactttaaccactaggccaaactcccggcc------------AC

AAACTTTATCAC---TTTTTA-----------------TGATGAATCACT

GGAGAAATATGATTCCATATCACCACAAAATTT-----------------

--------------------------------------------------

-------------------------ATAGCCAGCATTTT---GGGAATAT

AT-CCTTTGTTAGGTCAA--------------------------------

--------------------------------------------------

--------GTTTGCCTATATTTGATTGGCTATTGGAAGAACATATTTTAT

-------------------------TAGATTTACTTAACAAGATCTATTA

G--ATTCTTTCTGCTTGTCACTTCAATTAGAAGTGTTACATTCT

>Cgu

TGAGAGACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGGA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

TGT-GTGCTGTAGGGATTTTTGTCTCTCCCTCTC-TTCCTGAATTTCTCA

TTTATTCTTTGTCCTGAACCGTAGCAGCCTAGCCTCTTCCCCCAACTCTC

CCCCTATTTT---------GGGTAGAAA-TAGGGCTGAGGAACTATCCAG

TG---------TGCAGAATAGTGGTGCATCAATAA------TAAAAT--A

TTTAAAATTTCA--------------------------------------

--------------------------------------------------

----------------------------------------CCGTTGATTT

TTGCAGGCAACCATAAAAAGTGATTGGTTA--------------------

--------------------------------------------------

-------------AAAAACAGTACTGTTT---GGGGGGAAATC-GTACT-

--------------------------------------------------

---ATTTGATGA---TTTCATATTTTCTAA----------ACT-------

-------------------TTGATGAATTGGTTCAAAATTAAA-------

--------------------------------------------------

----------TATAAGACCTTTT---------------------------

--------------------------------------------------

--------CTAAAATTAAGCCATA---AGTGGTAGCATTTTTTAGG-TT-

----GTCATTGAAGAAATA-CAGTTTCTGAAAATG---------------

--------------------------------------------------

----------------------------------------TGTTCATAGC

CACCATTCCACA-----TTTATTTGTTTATTT---GGTGGTGGTGGTAGA

GCTAAATGTTAGGGCCTTTACACTGAGCTTTA------------------

--------------------------------------------------

----------------------ACCTTTTTAGGATAGGTCACTAGAGGAA

TATTTAAGAAAATTACTTT-------------------------------

--------------------------------------------------

-----TCCTTTTTT--AAAGAAATTTTTTTAAAT-----gttgtttttta

ctttgagacaagatcttgctacatttgcttgagctggcctcaaac-----

-----tggtgatcctcttgcctcagcctctcaagagtg------------

------------------------CATAGCTAGCTTTTT---GAGAATAG

AT-CGATTGTTAAATGAA--------------------------------

--------------------------------------------------

--------ATTTCTCTGTATTTGATCGGCTGTTGGGGTAGTGTAT-----

-------------------------TAGATTTCCTTAATGAAATTTATCA

G--ATTCTTTTTGCTTATCACTTCAATTAGAAGTGTTACATTCC

>La

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

AAT-----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

TGT-GTATCGTCAAGATTTTATGTCTTTCTCTCCCTCTCTCCTTCTCCCA

TTTTCCATTTATTCTTTGTCCTGAATTGTTACAGCCTAGTCTCTCCCTAT

AACTCCTGCTTATTTG---GGGTAGAAA-TAAGGGTGTGGAACTGGCCAT

AG---------TGAGGAATAGTGATATATCAATAA------TAAAAC--A

TTTAAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------CTGTTGACTT

T-GCAGGCAACCCCAAAAAGTTATTAGTTA--------------------

--------------------------------------------------

--------------AAAACAGTACTGTTT---GGAGAAAAATA-GTACT-

--------------------------------------------------

---GTTTGATCAGATCAAACCATATTTTCTAAACTATCATGAATTAAATG

TCAACCTGGACTTATGGCTTCTTTACATTGGTTCAAAATTAAA-------

--------------------------------------------------

----------TATAAGACCTTTT---------------------------

--------------------------------------------------

--------CTAAAATTACTCCACA---AGTATTACCACTTTTTTGGAT--

----GTCATTGAAGAAATA-CGATTTCAGAAAATG---------------

--------------------------------------------------

----------------------------------------TCTTCATAGC

CAGCCTTTTTTTTTTTTTTTTTTTTT----GTGATGGTGGTGGTAGTAGA

GCTCGAAGCCAGGGCCTTCAAACTGAACTACA------------------

--------------------------------------------------

----TCCTCAACCCTTTTGAAAAATTATTTTAAATGCTTttttatttt--

----gaaacgagatcttgtgaaatttggccacactgtcctcaacc-----

-----tggtgatcctcctacctcagcctctcaagaact------------

------------------------CATAGCCAACTTTTT---GAAAATAG

AG-CATTTGTTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTCTCTGTACTTGGTTGGCTGTTGGAGTAATATAT-----

-------------------------TAGATTTCCTTAATGAAATCTATCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

>Ts

TGAGAAACCTCTTCAGGACATGTACAACTGTCTGC--GTATCCTTCTT--

--------------------------------------------------

--------------------------------------------ACTTCC

TACCTGTTCT---------CAGTATAAA-AAGGGCTGGGAAACTGGTCAG

TA---------TGAAGAATAGTGATACATTTATAG------TAAGAGAAA

TTTAAAtttttgtttgtttgtttgttttttgagacagggtcttgcttt-g

tagttcagactggccctgaactcactatgtagcccaggcgagcctccaac

tcacagcaatcctcctgcctctgccttctgagtgcttggattacaggtgt

gagccaccacacctggc---------------------------------

--------------------------------------------------

-----------------------ATTGTGGTA------TGGGGTACCAGG

GGTTGAACTAGGGACCTTTCCTTGAGAGTCAG------------------

----------------------------------ATGCTGGGTCTCCTGA

GCTAAATCCCTGGCCACTAGGCGACTTTTTAAATAGTGGTACTATAGATT

AAACACAGGGCCTCTGCTCTGAGCTACATTGTTG-GTGTATTCT------

--------------------------------------------------

-----TCCCTTTTTTTTTTTTT-AACTTCTAAAA-----ttttatttt--

----gagaaaagatttctctaagtt-gccaaggctgggcttgaac-----

-----tggtgatccttctgcctcaaccttccaa-agta------------

------------------------CTTAGCTAGCTTTTT---GAGAATAT

AT-CTTTCGTTAAATGAA--------------------------------

--------------------------------------------------

--------ATTTTCCTGTATTTGATTGACTGTTGGAGTAATATT------

-------------------------TAGATTTCCTTAGCAAGCACTCTCA

G--ATTCTTTCTGCTTATCACTTCAATTAGAAGTGCTACATTCC

>Pcu

TGAGAAACCTCTTCAGGACATGTACAACTGTCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT----------AGATTTTTGTGTCTCCCTTAGTCC-TGAACTGTAGCA

GCCTAGCTT--CCCTATCC---------------------CCTCAATCCC

TGCCTTTTCT---------AGGTACAAA-TAAGGCT-------------G

TG---------TGAAGAACAGTGGTACATCTGTAA------TAAAACAAA

TCTAAAATGTTA--------------------------------------

--------------------------------------------------

----------------------------------------TTGTTGGCTT

T-GCAGGCATTCCCTAAAAGTGATTACTT---------------------

--------------------------------------------------

-------------TAAAATAGTACATTTT---GGTGAAAAAAA---TACT

--------------------------------------------------

---TTTTAATCA---GTGTATATTTTCTAA-------GGATCTATTGGGG

TAATCTGGACCTTGTAGTTTGCTTGTGTTGCTTCAAAATGAAG-------

--------------------------------------------------

----------TATAAAACCTTTT------CTAAAATCATGTCCCAT---a

gt-cagggatggtggtgcacacttgtaatcccagaatttgggagactgag

gcaggaggatcacagggagttcgaggctaatctgggctacatagtaattt

caaggtcagtctgaagtataaa--------gcaagaccctgtctccaaaa

ataacaaga-----------------------------------------

--------------------------------------------------

---------------------------------------------aaaaa

agc-----TCAAAAATTGTACCAC----------------TTTTT-GGAT

--GAATCATTGGAGAAATA---TTCCAGAAAATT----------------

--------------------------------------------------

----------------------------------------------CTCT

CATAGGCAGT---TTTTTATTATTAT-GCTTT------GGTAGTACTACA

GATTGAACACAGGGCCTCCACTTGGAGCTATA------------------

--------------------------------------------------

----------------------------TTCTTA-GTGTGTCAC------

--------------------------------------------------

-----TCTCTTTTTTT-------AACTT--AAAA-----ttttatttt--

----gagagacgattttcttaagtt-gactaggccaggtttgaac-----

-----tggtaatcctcctgcctcagcctttcaa-agta------------

------------------------CATAACCAG-TTTTT---GAGACTAG

AT-CCTTCATTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTCCCTGTACTTGATTGGCTGCTGAAGTAATATGT-----

-------------------------TAGATTTCCTTAGTAAACTCTCTCA

G--ATTCTTTCTGCTTGTCACTTCAGTTAGAAGTGCTGCACTCC

>Mc

TGAGAAACCTCTTCAGGACATGTACAACTGTCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT----------AGATCTTTGTGTCTCCCTTAGTCC-TGAACTGTAGCA

GCCTAGCTT--CCCTATCT---------------------CCTCAATCCC

TGCCTTTTCT---------GGGTACAAA-TAGGGCTGGGGGACTGGCCAG

TG---------TAAAGAACAGTGATATATCTGTAA------TAAAACAAA

TTTA------------------------agccgggcgtggtggcgcacgc

ctgtaatcccagcactcgggaggctgaggcaggaggatcattgtgagttc

aagaccagcctgggctacaaaagtgcgctcaaggccagcctcaactccat

agcgagaccctgtctcaaaaaggcaaaaaaaaaaaaataaataaataaat

aaaacaaatttaaaat----------------------------------

--------------------------------------------------

------------------------------------GTTATTGTTGGCTT

T-GCAGGCATTCCCTAAAAGTGATTACTT---------------------

--------------------------------------------------

-------------TAAAGTAGTAGGTTTT---GGTGAAAAAAAAA-TACT

--------------------------------------------------

---TTTTGATCA---ATATATATTTTTTAA-------AGATCTGTTGGGG

TAATCTGGACCTTGTAGTTTGCTTGTGTTGCTTCAAAATGAAG-------

--------------------------------------------------

----------TATAAAACCTTTT------CTAAAATCATGTCCCAT---a

gt-cagggattgtggtgcatacctgtaatcccagaacttgggagattgag

gcaggaggatcacagggacttctaggctaacctgggctacatagtaagtt

caaggtcagtctgaagtataaaa--------caagatcttgtcttaaaaa

atagtaaga-----------------------------------------

--------------------------------------------------

---------------------------------------------aaaaa

gg------TAAAAAATTATACCAC----------------TTTTT-GGAT

--GCATCATTGGAGAAATA---TTCCAGAAAATT----------------

--------------------------------------------------

----------------------------------------------GTTT

TATAGGCAGT---TTTTT-TTATTAT-GTTTT------GGTAGTACTACA

GATTGAACACAGGGCCTCCACTTGGAGCTATA------------------

--------------------------------------------------

----------------------------TTCTTA-GTGTGTCAC------

--------------------------------------------------

-----TCTCTCTTTTTTT-----AACTT--AAAA-----ttttatttt--

----gagagacgattttcttaagtt-ggccaggtcaggtttgaac-----

-----tggtaatcctcctgcctcagcctttcaa-cgta------------

------------------------CATAGCCAGTTTTTT---GAGACTAG

AT-TGTTCATTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTGCCTGTACTTGATTGGCTGCTGAAGTAATATATTATAT

-------------------------TAGATTTCCTTAGTAAGCTCTCTCA

G--ATTCTTTCTGCTTGTCACTTCAGTT----------------

>Od

TGAGAAACCTCTTCAGGACATGTACAGCTGTCTCC--GTATCCTTCTGAA

GTTC----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT----------GGATTTCTCTGTCTCCCTTAGTCC-TGAACTGTAACA

ATCTTGCTTCTCTCTCCCC-----TTGCTCCCCTCGCTTCTCTCTCCCCT

TGCTTTTTTT---------GGGCAC------------------TGGCCAG

TG---------TGAAGAACAGTGGTACCTCTGTGA------TAAAACAAA

TTTAAAATGTTA--------------------------------------

--------------------------------------------------

----------------------------------------TTGTTGGCTT

T-GCAGGCATTCCCTAAAAGTGATTAGTT---------------------

--------------------------------------------------

-------------TAAAATAGTATTTTTT---GTTGAAAAAA----TACT

--------------------------------------------------

---TTTTGATCA---ATGTATATTTTCTAA-------AGATCAATTGGGG

CAATCTGGACCTTATAGTTTCCTTATATTGCTTCAAAATTAAA-------

--------------------------------------------------

----------TATAAAACCTTTT------CTAATGTCACATCCCAT---a

gccaagggatggtggtgcacacctgtaatcctagaatttgggagattgag

gcaggaggatcacagggagttcgaggccaacctgggctacatagtaagtt

caaggtcagtccaaagtataaaagcataaagcaagaccctgtgtcaaaaa

ataacaaca-----------------------------------------

--------------------------------------------------

---------------------------------------------aaaaa

ataag---TGAAAAATTTTACCAC----------------TTTTTAGGTT

--GGATCATTGGAGAAATA---TTCCACAAAATT----------------

--------------------------------------------------

----------------------------------------------CTTT

CATGGGCAGC---TTTTTATTGTTATTATGTTTTTTTTTTTTTTTTTTTN

NNNNNNNNN--------------------------GGCAGAA---ccagg

gattgaactcagaccctcgcgcttgccagggaagcgcttattccattgag

ccatctccccggcccc---TTATTATTATGTTTTGGTAGTACTGTAGATT

GAACACAGGGCCTCTGCTTGGAACTATATTCTTA-GTGTGTCCC------

--------------------------------------------------

-----TCTCTTTTT---TTTTTAAACTT--AAAA-----ttttatttt--

----gagagaggattttcctaagtt-gcccaggccaggtttgaac-----

-----tggtaatcctcctgactcagcctttcaa-agta------------

------------------------CATAGCCAGTTTTTT---GAGACTGG

AT-CCTTCATGAAATGAA--------------------------------

--------------------------------------------------

--------GTTTTCCTGTACGTGATTGGCTGCTGAAGTAATTTATTATGT

TGGCTGCTAAAGTAATATATTATGTTAGATTTCCTTAGTAAGCTGTCTCA

G--ATTCTTTCTGCTTGTCACTTCAGTTAGAAGTGCTGCACTCC

>Cp

TGAAAAACCTCTTCAGGACATGTACAACTGTCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT----------GGATTTT-CTCTCTCCATTAATCC-TGAACTGTAGCA

GTCTAACTTCTCCCTTCACTAGGGTACA----------------CTTCAC

T-CCTTTTCT---------GGGTACAAA-TAGTGCTGGGGGAATGGCCAA

TG---------TGAAGACTG-TGATACATCTGCAG------GAAAACAAA

TTTAAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------TTGTTGACTT

T-GCAGGTGTTCCCTCAAAGTGAT--------------------------

--------------------------------------------------

-------------TAAAATAGTTCTGTTT---GGGGAAAAAAGAA-TACT

--------------------------------------------------

----TTTT-----------------------------------GATCAGT

CAGTCTGGACCTTATGGTTTGCTTATGTTGCTTAAAAATTAAA-------

--------------------------------------------------

----------TATAAAACCTTTT------CTAAAATTATGTTGCAT---a

gcca-ggaatggtggctcacatctgtaatcccagcatttaggagactgag

gcaggaggatcaccaggagttcaaagttatcctgggctgcatagtgggtt

ca---------ttttatagtgaactataaaatgagaccctccctcaaaaa

ctaataaca-----------------------------------------

--------------------------------------------------

---------------------------------------------aaaaa

a-------TCACAAATTTTGCTGT----------------TTAGGGGGAT

--GAATCATTGGAGAAATA---TTCTAGAAAACT----------------

--------------------------------------------------

----------------------------------------------CCTT

CATAGGCCGC---TTTTTATTGTTATATATATTTTT-TGGTGGTACTATA

AATTGAACATAGGGCTTCTGCTTGGAACTATA------------------

--------------------------------------------------

----------------------------TTCTTA--TGTGTCCCTCTGTT

TTGTTTT--------ttttttttttttag-taccaaggatcgaactcatg

accttgtgtttgccaggcaggcatttgtgccgctgagctatatcctcagt

cc---TCTTATTTT---TTTTTTAACTTTTAAAA-----ttttatttt--

----gaga---gatttccctaagtt-gcccaggcagggcttgaac-----

-----tggtaatcctcctgcctcagccttccat-tgta------------

------------------------CGAAGCCTGCTTTTT---GAGAGTAG

AT-CCTTAGTTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTGC-TGTACTTGATTGGTTGCTGAAGTAATATAT-----

-------------------------TAGATTTCCTTACCAAGCTCTCTTA

G--ATTCTTTCTGCTTGTCTCTTCAGTTAGAAGTGCTGCACTCC

>Dp

TGAGAAACCTCTTCAGGACATGTACAACTGTCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT----------GGATTTT-CTGTCTCCGTTAGTCC-TGAACTGTAGCA

GTCTAATTTCTCCCTTCAC---------------------CTTCACTCCC

TACCTTTTCT---------GGGTACAAA-TAGGGCTGTGGGACTGGCCAG

TG---------TGAAGAATAGTGATACCTCTGCAG------GAAAACAAA

TTTAAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------TTGTTGGCTT

T-GCAGGTGTTCCTTCAAAGTGAT--------------------------

--------------------------------------------------

-------------TAAAATAGTACTGTTT---GGGGAAAAAATAA-TATT

--------------------------------------------------

-----TTGATCA-----------------------------GTCAATCTG

GACCTT-------ATGGTTTGCTTATGTTGCTTCAAAATTAAA-------

--------------------------------------------------

----------TATAAAAGCTTTT------CTAAAATTACGTTGCAT---a

gg-cagggacgatggctcatatctgtaatcccagcacttaagagactgag

gcaggaggatc-cccggagttcaaagttgtcctgggctgcatagtgggtt

ca---------tgttatcctggactgcata-gtgggccctgttgtaaaaa

ctaacaacc-----------------------------------------

--------------------------------------------------

---------------------------------------------aaaag

aaaaa---TCACAAATTTTACTAC----------------TTTGGAGGAT

--GAACCATTGGAGAAATA---TTCTAGAAAACT----------------

--------------------------------------------------

----------------------------------------------CCTT

CATAGACAGC---TTGTTATTATTATATATATACTTTTGGTGGTACTGTA

AATTGAACATAGGGCCTCTGCTTGGAGCTATA------------------

--------------------------------------------------

----------------------------TTCTTA-GTGTGTCCCTCTGGT

TTTTGTTTTTTG----tttttttttttaagtactggggatggaactcact

accttgtacttgccaggtaggcatttgtgccgctgatctatatccccagt

cc---TCTTACTTTCTTTTTTTTAACTTTTAAAA-----ttttatttt--

----gagagaatatttccctaagt--gcccaggcaaggcttgaac-----

-----tggtaatcctcctgcctcagccttccat-tgta------------

------------------------GGCAGCCTGCTTTTT---GAGAGTAG

AT-CCTTAGTTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTGC-TGTACTTGATTGGTTGCTGAACTAAAATAT-----

-------------------------TAGATTTCCTTAGCAAGCTTTCTCA

G--ATTCTTTCTGCTTGTCACTTCAGTTAGAAGTGCTGCACTCC

>Cop

TGAGAAACCTCTTCAGGACATGTACAACTGTCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAC----------GGATTTTG-TGTCTCCCTTAGTCC-TGAACTGTAGCA

GCCTAGCTTCTCTCTCCCC-----------------------TCACTCCC

TGCCTGTTCT---------GCGTACAAA-TAGGGCTGGGGGACTGGCCAG

TG---------TGAAGAATAGTGATACATCTGTAA------TAAAACAAA

TTAAAAATTTTA--------------------------------------

--------------------------------------------------

----------------------------------------TTTTTGGCTT

T-GCGGGCATTCCCTAAAAGTGATTAGTT---------------------

--------------------------------------------------

-------------TAAAATAGTACTGTTT---GGGGAAAAAAGAA-TACT

--------------------------------------------------

---TCTTGATCA---ATCTGTATTTTCTAA-AGTATGATCAATTAAGGAG

CAAGCTGGACCTTATGGTTTGCTTATATTGCTTCAAAATTAAGTATAAAG

CCTTTTCT---tttttcttttttttttttt-aatgtgggtaccaggagtc

gacctcaggacctcgcgcttgccagcaggtgcttctgctgctgagcaata

tcaccggccc---TTTTTTTCCTTTATGTG---ggtactgggagtccaac

tcaagacctcgcgcttgccaggcaggcacttatgctgctgagctatctca

ccggccc---TATAAAACCTTTT------CTAAGGTTATGTCACAT---a

gc-cggggatggtggcgcacacctgtaatcccagcacttgggaggctgag

gcagtaggatccccaggagttcaaggccagcctgggctacatagtgagtt

ca--------aggtcagtctgaactacaaagcaagaccctgtctcaaaaa

ataacaaca---gggccagtgagatagctcagcagcataagtgcctgcct

ggcaagcgcgaggtcctgagtttgactcccggtacccacgtaaagggaaa

aaaaaggccagtgatatcactcagtggtgcaagcacctgctggcaagcat

gaggtcctgagttca-actcctggtacccacattaaaaaaataaaaataa

aaaag---TCAAAAATTTTACCAA----------------TTTTTGGGAT

--GAATCATTGGAGAAATA---TTCCAGCACATT----------------

--------------------------------------------------

----------------------------------------------CCTT

CATAGGCAGC---TTTTTATTACT----------TTTTGGTGGTACTATA

GATTGAACACAGAGCCTCTGCTTGGAGCTATA------------------

--------------------------------------------------

----------------------------TTCTTA-GTGCGTCCCTCCCTT

TTTTTTCTTTT---------------------------------------

--------------------------------------------------

-------TTTTTTTTTTTTTTTTAACTTTTAAAA-----ttttatttt--

----gggagaggatttccctaagtt-gcccaggttaggcttgaac-----

-----tggtgatcctcctgcctcagccttccaa-agta------------

------------------------CATAGCTAGCTTTTT---GAGAATAG

AT-CCTTTGTTAAATGAA--------------------------------

--------------------------------------------------

--------GTTTGCCTGTACTTGATTGGCTGCTGAAGTAATATAT-----

-------------------------TAGATTTTCTTAGCAAGCTCTCTCA

G--ATTCTTTCTGCTTGTCACTTCAGTTAGAAATGCTGCA----

>Sv

TGAGAAACCTCTTCAGGACATGTACAACTGCCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CGT-----TGTAAGGATTTTG-TGTCTCCCTTTC-CCTCCTCCTTTTTCC

ATTTAATTTATTTCTGAACTGAAACAGCTTAGCCTTTCCTCCCG-CTCTC

CCCTTTT------------GGGTAGACA-CAGGACTGGGGAACCAGCCAG

TG---------TGAAGCATACCTCCACATCTATAA------TGAAACAAA

TTTTAAATCTTA--------------------------------------

--------------------------------------------------

----------------------------------------TTGTTGAATT

T-GTAGGCAGTCCCCAAAATTTTTA-------------------------

--------------------------------------------------

-------------AAAAATAGTACTGTTT---GGGGACTGTGTAG-TACT

--------------------------------------------------

---ATTTAGTTA---ATTCATATTTTCTAAACT----TTGAACTGAGGGT

CAACGTGGACCTTATGGTTGGTTTACAATGGTTCAGAATTAAA-------

--------------------------------------------------

----------TATAAAA-CTTTTTTT------------------------

--------------------------------------------------

--------CTAAAAATGTCACAAA-------TTTTACCACTTTTTAGTAT

--GAGTCATTGGAGGAATGTGATTCCA--AAGTT----------------

--------------------------------------------------

----------------------------------------------CCAA

AATATGATTCCAAAAGTTCATAGACAG-----------------------

--------------------------------------------------

-----------------------------CTCTTTGGAAATAGAT-CTTT

TGTT----------------------------------------------

--------------------------------------------------

-----------AAATGAA--------------------------------

--------------------------------------------------

--------GTTTACCTACATTTTATTGTCTGCTGAAGTAATATATATCT-

-------------------------TAGATTTGCTTAACAAGATCTACCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

>Gg

TGAGAAACCTCTTCAGGACATGTATAACTGCCTAC--GTATCCTTCTGAA

ATTT----------------------------------------------

--------------------------------------------------

----------------------------------------------GAGA

CAT-GTATTGTAAGGATTTTG-TGTCTCCCTCTCCCCCCTACATTTTTCA

CTAATCCTTAGTCCTGAACTGTAGTAGCCTAGCCTTTCCTCCTCAC-CCC

TGCCTTTTTTTT-------TGGTAGAAA-GAGGGCTAGGGAACTAGACAG

TA---------TGAAGAATAGTAATAT-TCTATAA------TAAAACAAA

TTCAAAATTAAAAAACAA---tttttatggtactggggattgaacccagg

ggtcctctaccactgagctacatatacctccagccc---ATTTAAAAAAA

---tttttttttgcagtactgggggttgaacccagaggcattctacctct

gagctccacccccagccc---TATTTTTTATTCTTTA---ttttgaaaca

cgatctcactaagttgtggaggcctcactaagtagctgaggctggccgag

aaccagtatcctccagtctcagccttccaaatactgggattacaagcgtg

caccaccatgcccagct---TGGCACAAATTTAAAATTT-TATCATTGAC

TTTGCATGTAACCCCCAAATGTGATTAGTT--------------------

--------------------------------------------------

-------------AAAAATAATACTGTTT---GGGGAAAAATTGG-TGCT

--------------------------------------------------

---GTGTGATTA---ATCTATATTTTCTAAGCT-ATGATGAATTAAGAGG

CAACCTGGACCTCATGGTTTGCTTGTAATAGTTCAAAATTAAA-------

--------------------------------------------------

----------TATAAAAC------TT------------------------

--------------------------------------------------

--------CATAGAATTATGCCAC----AAATTTTACTACTTCTTATGTT

--GTTA---GAGAAATAGGA--TTCCAGTAAATT----------------

--------------------------------------------------

----------------------------------------------CCTT

CATAA----CCAGC------------------------------------

--------------------------------------------------

-----------------------------TCTTT-GGGAATAGAT-CCTT

TGTT----------------------------------------------

--------------------------------------------------

-----------AAGTGAA--------------------------------

--------------------------------------------------

--------GTTTGCCTGTACTTTATTGGCTGTTGGAACAGAATATCATAC

-------------------------TAGATTTGCTTAACGAGATTTATCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

>Oc-TDB

--------------------------------------------------

----------------CTTTTAGGTTCGCAGATCTCGCACTGTGGTGGAT

TCTTTGTCTTATCATGAACTATAGCACTCTA-CCTCCCCCAACACCACCA

CTTTTTTT-----------GGATAGAAA-TATGGCTGGGTAACCGGCCAG

TG---------TGAAGAATAGTGATACATCTATAA------CAAGTCAAG

TTCAAAGTTTTA--------------------------------------

--------------------------------------------------

----------------------------------------ATGTTGATCT

TACAAGTAAAAATAGAAAATGATTAGTT----------------------

--------------------------------------------------

-------------AAAAATAGTACTATTT---GGAAAAAAAGTACTATTT

--------------------------------------------------

-----------GGTTAGTCCATAGTCTCTATAATATGATGAATTAAAGGG

TAACCTGCACTTTGTGGATTATTGATATTGATTCAGTATTAAC-------

--------------------------------------------------

----------GATGAGC-CTTTTTT-------------------------

--------------------------------------------------

--------CT-AAAATTATGCCAA------GTTATAACACTTTTTTAGGA

T-GAGTCATTGGGAAAACATGATTCTG--GAGAT----------------

--------------------------------------------------

----------------------------------------------TTTC

TTTATGG--CCAGCTTTT--------------------------------

--------------------------------------------------

-------------------------------------------TGGGAAC

ACAGCCTTTATAAATGAA--------------------------------

--------------------------------------------------

--------GTTTGCCTGTACTTGATGGGTTGTTGGAATAATATAT-----

-------------------------TAGATTTGCTTAACCTGATCTATCA

G--ATTCTTTCTGCTTATCACTTCAGTTAGAAGTGTTACATTCC

Locus 503-14

>ID4

--------------------------------------------------

---------------------tttttttgcggtgctggggat--------

----cgaacccagggcctcgcgcatgctaggcaagcgctct-accactga

gctacatccccagcccc---------------------------------

--------------------------------------------------

------------------

>ID4

--------------------------------------------------

-------------------------------------------------g

gggctggggatgtagctcagtggtagagcgcttgcct----agcatgcgc

gaggccctgggttcgatccccagcaccgcaaaaaaa--------------

--------------------------------------------------

------------------

>ID_B1

--------------------------------------------------

---------------------ggggctggggatgtagctcagttggtaga

gcgcttgcctagcatgcgcgaagccctgggttcgat-ccccagcaccgca

taaa-----accgggcgtggtggcgcacgcctgtaatcccagcactcggg

aggtggaggcaggaggat---cagaagttcaaggtcatcctcggctacat

agcgagttcgaggccagcctgggctaca---tgagaccctgtctcaaaaa

aaaaaaa-------------------------------------------

--------------------------------------------------

------------------

>Mm

GTATGCCCTAGGGCAATTGGGATGCCTG--GCAGGGAGTAAG--GAATCT

AG------CTTCCTTGGTGACACCGTTAATGGG------------CACTA

TAGAAAATAAAAACCAGTGTGCTCT-------------------------

--------------------------------------------------

--------------------GGTACAGAC---ATT---------------

--------------------------------------------------

-----------------------------------------------AAG

AACTG----AAAGAAGG---------------------------------

--------------------------------------------------

--------------------------------TAGCAGCGGAGCATTAAC

TCAAGTTCAGGGCCCTGTGTGTCCCATC--TAGGAAGTAGGCCCTGTTTC

GGCCTTAACTTTTTTTT-ACCCC----AATGCAG--TGAGGCCGAGGTTT

TGGACCACAGCAAGGACC

>Rn

GTATGGCCTAGGGCAATTGGGATGCCTG--GCAGGGAGGAAG--GAATCA

AATACTAGCTTTCTTGGTGCCACAATTTATGGG------------CAGTA

TAGAAAATGAAAGTCAGAGTTCTTT-------------------------

--------------------------------------------------

--------------------AGTACAGACATTATT---------------

--------------------------------------------------

-----------------------------------------------AAG

AACTT----CAAGAAGG---------------------------------

--------------------------------------------------

--------------------------------TAGCAGCAGAGCATGAAA

TCAAGCCCAAGGCCCTTCTAGGAAGTGT------------GCCCTGTTTT

GGCCTTAACTTTTCTAT--CCCC----AATGCAG--TGAGGCCGAGGTTT

TGGACCACAGCAAGGACC

>Mu

GTATGGCCTAGGACAACTGGGATGCCTG--GCAGGGAGTAAG--GAATCA

AATACTGGCTTTCTTGGTGCCACAATTTATGAG------------CACTA

TAAAAATTGAAATCCAGAGTTCTCT-------------------------

--------------------------------------------------

--------------------AGTACAAACATTATT---------------

--------------------------------------------------

-----------------------------------------------AAG

AACTT----GAAGATGG---------------------------------

--------------------------------------------------

--------------------------------TAGCAACGGAGCATGTAA

TCAAGCCCAAGGCCCTGCGCGTCACATC--TAGGAAATGTGCCCTGTCTT

GGC-------CTTTTCTACCCCC----AATGCAG--TGAGGCAGTGGTTC

TGGACCACAGCAAGGACC

>Oz

GTATGGCTTGGGGAAACTGG-ATGCCTG--GCAGGGAGTAAG--GAATCA

GATACAGGCTTTCTTAGTGCCACAATTATTGGT-------------ACTA

TAGAAAATGAAAACCAGAGTTCTCT-------------------------

--------------------------------------------------

--------------------AGTGCAAACATTATA---------------

--------------------------------------------------

-----------------------------------------------AAA

GAATTT---CAAGGTGT---cccggtggtggttggagccagaggcaggtg

gatctctgacgtcagactggtctatggtgcaagtttcgggacagccaggg

ctacacagagagaccctgtcttgaaaaaccagagagagagagagagagag

aggagagagaagaaaagaagtgagaaagaagaagaaagagaagaaaagaa

--------------------------------------------------

------------------CTTTAAGATGT---TAATAGCAAAGCATTAAA

TCAAGCCTAGCTAGGGTCCTGTGCTCTGTGCCACT-------CCTGTCTT

GGCCTTA---CTTTTCTATCCCC----AATGCAG--TGAAGCTGAGGTTT

TGGACCACAGCAAGGACC

>Se

GTATGGCCTAGGACGCTTGGGATGTGTG--GTAGGGAGTAAG--GAGTCA

AATACTGG--TTCTTGGCTTTGTAAATTATGAG-----------ACCCTG

TGCAAAATGAAAACCAGGGTTTCT--------------------------

--------------------------------------------------

--------------------AGTTCAGACATTACT---------------

--------------------------------------------------

-----------------------------------------------AAG

AATTT----CAATATGG---------------------------------

--------------------------------------------------

--------------------------------CAATAGCAAAGCATTAAC

GTAAGCTGAGGGCCTTGGGTGACACAC--TGAATTGTGG---CCTACGTT

GGGCCTACCCCTTTACCCTCCAC------TGCAG--TGAGGCTGAAGTTC

TGGACCACACCAAGGACC

>Jj

GTATGGCCTAGGGCAATTGGGATTCCTG--GCAGGGAGCAAT--GAATCA

AATACTGGCATTCTTAGCTCCATAACTTGTGGA-----------GTTTTA

TGCAAAATAACAACT-AGGGTCCCTA------------------------

--------------------------------------------------

--------------------GT-TCAAACATTATT---------------

--------------------------------------------------

-----------------------------------------------AGG

A-TTC----CAGTGTGG---------------------------------

--------------------------------------------------

--------------------------------CACTATCAGAGCTTTTAA

CCAAGCCCAGGGCCCCTCGTGAC---------ATACCTATGAAGTATCTT

GCCCTA-------ATTTCTTACTCCCCACTCCAG--TGAGGCCAAGGTTT

TGGACCACACCAAGGACC

>Pca

GTATGGCCCAGGGCAATTGGGATGTGTG--GCAGGGAGTAAG--AAGTCA

AATTCTGGCATTCTTGGCTCCATAATATGTAGG-----------GCCATG

TACAAAATGAAAATC-AGAGTCCCTA------------------------

--------------------------------------------------

--------------------GT-CCAAACATTATT---------------

--------------------------------------------------

-----------------------------------------------AAG

CATTT----CAGTATGG---------------------------------

--------------------------------------------------

--------------------------------CAACAGAAGAGCATTAAA

CCACACCCAGAGCACTCATAAAG--------CATGCTCTGTGTCAGTCTT

ACTCT------------TCTACTCCCCACTGCAG--TGAGGCTGAGGTTT

TGGACCACACCAAGGACC

>Asp

GTATGGCCTAGGGCAATTGGGATGTGTG--GCAGGGAGCAAG--GAGTCA

ATTATCGGCATTCTTGGCTCCATAATTTTTAGA-----------GCCCTG

TACAAAATGAAAACC-AGGGACCCTA------------------------

--------------------------------------------------

--------------------GT-TCAAGCATTACT---------------

--------------------------------------------------

-----------------------------------------------AAG

CATTT----CAAAATGG---------------------------------

--------------------------------------------------

--------------------------------CAACAGCAGTGCATTAAA

CCAAGCCCAGGGCCCTGTGTGAC----------ACACCCACAAAGTACTC

CCTGTCT----CACCCTTCTACTCCCTGCTGCAG--TGAGGCCAAGGTTT

TGGACCACACCAAGGACC

>Cgu

GTATGGCCCAGGGCTGGTAGAATATGTA--ACAAGGTGTAATATGAGTCA

AGCACTTCTGGGTTTGGTGCCTTCATAATCCATGGG--------CTGCTA

GGTAAAATGAAAA--TGAGTGTCCTT------------------------

--------------------------------------------------

--------------------AGTTCAAACGTTTTT---------------

--------------------------------------------------

-----------------------------------------------CAG

AACTT----CAAGATGG---tgcagatgggagcatagtgcagtggttaga

gcacttgcctagcatgctcaaggccctgggtttgagtccccagtaccaca

taaagactagctaggtatagtggtgcgtgcctataatcccagcacttggg

agg-------acaagaaaatctccgagttcaaggccagcctgagctacat

agtgagttcaggaccagcctagaatgtagtgtgagaccttgtctcaaaaa

aaaaaaaaaaaaaaaaa---------------------------------

--------------------------------------------------

------------------GTTCAGAGTGG---TAACAGCAAAACATTAAA

CCAGGCTCAGGGCCCTGTGTGACATACC--CATGAAGTATGCCCTTCCAT

GGCCTTAATCCTCCTCCCTACCTACCCACTACAG--TGAGGCTGAAGTTC

TGGACCACACCAAATACC

>La

GTATGGCCTAGCACAGTTGGGATAAGTA--ACAAAGTGTAACAAGTCAAG

TGTTACTGGGGTTTGTGGCTCCAAATTTATGGG-----------CACCTA

AGTGAAATGAAAATG--AGTATCCTT------------------------

--------------------------------------------------

--------------------AATTCAAACATTATT---------------

--------------------------------------------------

-----------------------------------------------AAG

AATTT----CAAGATGA---------tggga--------------ctagg

ggcattgctgaggatgctcaaagccctgagtttgattccccagcaccaca

taaagattagctgggtattgtggggcatatctgtaatctcagcacttgga

aggctgggacaagaagattgctgtaagtttagggccagcctggactacat

aacgagttcaggactagcttggactacagggcaagaacctgtctcaaaaa

aaaaaaaaa-----------ttcaat---ggactggaggaatatctcagt

ggttaaaatgcttatttagtaagcacaaggtcctcggtttgattcttcag

cgccac---gtact---agctgggcgtagcggtgcatgcctgtaatccag

cactcgggaggctgcagtaagagaattgccttgtattcaaggccagtttg

ggttacaaagtgagttcagggccagcttggactatagagcaagaccttgc

ctc---aaaaaaaaa---TTTCAAGATGG---CAGCAGTAGAACATTAAA

CCAAGCTGAGGGCCCTATGTAACATACC------CGTAAAGTGCCCTACT

TCGGCTTTAATCCTCTGCTCCTTCCCCACTACAG--TGAGGCCGAAGTTC

TGGACCACACCAAGGACC

>Pcu

GTACGCCCTAGGGCAGTTGAGATGTGTGAGACAGGGAGTAAG--GAGTCT

AGTACTGGAG-TCTTGGGTTTGTAAATTGTGAG------------CCCTG

TGCAAAATGAAAAATTAGTTTTCCTG---GTTCAGGCAATTTT-------

-------------------------tttgcgggggtggggaggactaggg

attga--actcaggactttgcatttgtcaggcaggtccttacaccactaa

gccatatccccagcct----GGTTCAGACGTT------AAGAATTT---c

aggctagggatatagctcagcaacag-cgcattacctgcctggcaagtgc

aaggtcctgagtttaattcctggtaccaaaaaaaaaaaaaaaaa---AAG

GAATTT---CAAGATGA---------------------------------

--------------------------------------------------

--------------------------------CAATCACAGAGCATTAAA

CTAAACAA-TGGCCCTGTGTGACACATT--CCTGAAGTATGCCCTAC-TT

GGGCTTA------CCCCCTCACCCTCCACTGCAG--TGAGGCTGAAGTTC

TGGGCCACACCAAGTACC

>Mc

GTATGGCCTAGGACAACTGAGATGTGTG--GCAGGGAGTAAG--GAGTCT

AGTACTGGGG-TCTTAGGTTTGTAAATTGTGAG------------CCCTG

TGCAAAATGAAAAGTCAATTTTCCTG---GTTCAGGCATTTTG---tgtg

tgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtaggctag

ggattgaactcaggaccttacatttgtcaggcaggtccttacaccactga

gccatatccccagcca----GGTGCAGACATT------AAGAATTT---c

aggctaggtgtatagctcagtagcag-cacattacctgcctggcaagtgc

aaggtcctgagtttaattcctggtacc----------aaaaaaa---AAG

GAATTT---CAAGA------------------------------------

--------------------------------------------------

--------------------------------CAATCACAGAGCATTAAA

CTAAGCCAGTGGCCCTGTGTGACACATT--CTTGAAGTGTGCCCTAC-TT

GGGCTTA------CCCCCTCACCCTCCACTGCAG--TGATGCTGAAGTTC

TGGACCACACCAAGCACC

>Od

GTATGGTCTTGGGC-CATGGGGCGTGTG--GCAGGAAGTAAG--GTGGCT

---CATGGGGGTCGTGGCCCCGTAATTACCACTAAATTTGTAGGGCCCCA

AGCAAAATGAAAAGTCACTT------------------------------

--------------------------------------------------

------------------------AAAAATT-AGT---------------

--------------------------------------------------

-----------------------------------------------AAG

AGTTT----CAAGATGG---------------------------------

--------------------------------------------------

--------------------------------CGACAGCAGAGCAT-CAG

CCAAGCACAGGGCCCTACGTGACA---GCCCCCGAAGCCTGCTTTGTCTT

GGCCTTGT-----CCCCCTCCCC----ACTGCAG--TGAGGCGGAGGTTC

TGGACCACAGCAAGAACC

>Cp

GTATGGCCTAGGACGCTTGGGATGTGTG--GTAGGGAGTAAG--GAGTCA

AATACTGGT--TCTTGGCTTTGTAAATTATGAG-----------ACCCTG

TGCAAAATGAAAACCAGGGTTT-CTA------------------------

--------------------------------------------------

--------------------GT-TCAGACATTACT---------------

--------------------------------------------------

-----------------------------------------------AAG

AATTT----CAATATGG---------------------------------

--------------------------------------------------

--------------------------------CAATAGCAAAGCATTAAC

GTAAGCTGAGGGCCTTGGGTGACACA-----CTGAATTGTGGCCTACGTT

GGGCTTA------CCCCTTTACCCTCCACTGCAG--TGAGGCTGAAGTTC

TGGACCACACCAAGTACC

>Dp

GTATGGCCTAGGACACTTGGGATGTGTG--GTAGGGAATAAG--GAGTCA

AATACGGGGGTTCTTGGCTTTGTAAATCGTGAG-----------GCTCTG

TGCAAAATGAAAACCAGGGTTT-CTA------------------------

--------------------------------------------------

--------------------TT-TCAGACGTTACT---------------

--------------------------------------------------

-----------------------------------------------AAG

AATTT----CAATATGG---------------------------------

--------------------------------------------------

--------------------------------CAATAGCAAAGCATTAAA

TTAAGCCAAGTACCCTGGGTGACACA---TCCTGAAGTGTGGCCTACCTT

GTGTTTA------CCCCTTCACCCTCCACTGCAG--TGAGGCCGAAGTCC

TGGACCACACCAAGTACC

>Cop

GTATGGCCTAGGGCGGTTGGGATGTGTG--GCAGGGAGTAAG--GAGTCA

AATACTGGGGTTCTTGGCTTTGTAAATTGTGGG-----------GCCCTG

TGCAAAATGAAAATCAGTGTTC-CTA------------------------

--------------------------------------------------

--------------------GT-TCAGACATTATT---------------

--------------------------------------------------

-----------------------------------------------AAG

AATTT----CAAGATGG---------------------------------

--------------------------------------------------

--------------------------------CAATAGCAGAGCATTAAA

CTAAGCTGAGGGCCCTGTGTGACATA--TCCCTGCAGTGTGCCCTACCTT

GGGCTTA------CCCCTTCACCCTCCATTGCAG--TGAGGCCGAAGTTC

TGGACCATACCAAGTACC

>Sv

GTAAGACCTTGGGTATTTGGCACATGTG--GCAGGGAGTAAG--CAGTTA

AATACTGGGATTTTTGGCTCCATAATGTGTGGG-----------GCTCTA

TGTAAAATGAAAATCA-TGATCCCTA------------------------

--------------------------------------------------

--------------------GT-TATTCTT--------------------

--------------------------------------------------

-----------------------------------------------AAG

AATTT----CATGATGG---------------------------------

--------------------------------------------------

--------------------------------CAACAACAGAGCATTAAA

CCAAGCCCAGGACCCAGTGTGACAGACACACCTAGAGCATGCCCTGCCTT

GGCCTTA------CCACTCCACCCTCCATTGCAG--TGAGGCTGAAGTTC

TGGACCACAGCAAGGACC

>Oc

GTACGACCTGGGGCACCTGGAATGTGGA--GCAGGGATTGAA--GAGTCG

AGTACTGGGGGCCGGGACTCTATAATTTGTGGG-----------GC-CTG

TGCACAGTGAAAGGT--GGGGCCCTT------------------------

--------------------------------------------------

--------------------GGGTCCAAAATGAAG---------------

--------------------------------------------------

-----------------------------------------------AAT

GTCAG----GATGGTGA---------------------------------

--------------------------------------------------

--------------------------------CAG---CAGAGCACTGCA

CCAAGCCCAGGGCCCCGCAGGAC--GTCCTCTTGACGAGGGCCCTGCCTT

GGCCTTG----TTCTTCCCCCA-CCCCACTGCAG--TGAGGCCGAGGTTC

TAGACCATAGCAAGAATC

Locus 439-15

>ID4

--------------------------------------------------

-------------------------------tttttttgcggtgctgggg

atcgaacccagggcctcgcgcatgctaggcaagcgctctaccactg-agc

tacatccccagcccc-----------------------------------

--------------------------------------------------

----------

>ID2

--------------------------------------------------

----------------------ggggctggggatgtagctcagtggtaga

gcgcttgcctagcaagcgcgaggccctgggttcgatcctcagcaccgcaa

aaaaa---------------------------------------------

--------------------------------------------------

----------

>Mm

GAGGTGGGGAGACCTTGTACAGGTGGAAAGATACCATGCTGGAAAGAGCC

TCTCCCTCTCAGTTTGGAA--GTAAGTA---AAATTGGTTCTGGTAGGTC

ATTGTGATAAGTGAAGCC---TGTCTTTTTGGTTTCTTTCCCTTGT----

-----------ACAACTGACTTATTACATATGAATAG---CTATGTG--C

CCATA-GTAATGTGCT-----------------CA--CTATCATGTAGAC

CACCTGAGACATCCAT---TACTTT-AC----------------------

--------------------------------------------------

---------------------------TGTGGGC--TCATGCTGGATTGT

T-----CAAAAAGCTATGAGCTT------------tgggtgatgctggcg

atcaa-tctagggccttatgcatgcaaggtcagccctctgccagtggagc

tagatccctagtccc---CA---------AAGGTTAGAGTGTT-------

----GAG-TAT-----CACTTT-----------------------GTAAA

ACATACTTGCTTATTTAT----CAC-------------------------

--------------------------------------------------

-------------------------------AGTTTCCCCTTTT-AAATT

GTATCTTTG-AAAACT---TATTTGGAGAAAATT-GCTATGAGCCTATTT

A-TCGTCTTTATTTCCTGTTTGAAATTGA-CTAC---GTTCTGATTTTCT

GTGGATAAATCAGAGA--CAAATATTTA----TTA---GACGG------T

TTCTGTTTACAGGTTTTTTTTTCTTTTTT---------GTGAGTGCA---

--------------------------------------------------

--TGTATCTTATTTTTAAATTCAGTATCTATTTCTAAA---ATGCAGTAG

AACAAATGCTGAATTGGATTAT----GAAATGTCTTCTCAGTATTAATGT

ATTCCCTGC----ACAAACACTGAGGGCCTGCTATGTTCAAGGTTCTGAC

TC------AGCATAATGCAT------------------------------

--------------------------------------------------

GTTTCTATTTGACTG--TAAACGAT-GAAAAGCTGTGTT----TATAT--

-GTTATTCTCCCCCTG-CCCCCTTTCAG--TCAACAGGTTCTAGGGAGAA

AAACAGGCAC

>Rn

GAGGTGGGGAGACCTTGTACAGGTGGAAAGATACCATGCTGGAAAGTGCC

TCTCCCTCTCAGTTTGGAA--GTAAGTA---ATATTGGTTCTGGTAG-TC

ATTGT---AAGTAAATCC---TGTCTGTTTGGTTTCTTTCCCTTGT----

-----------ACGACTGATATATTACACGTGAATAG---CCATGTGTGC

CCGTG-GAAATGTGCTTTAATTTAGTAAAGTCTCA--GTATCATGTAGAT

CACATGAGGCA-CTAT---TACCTT-AC----------------------

--------------------------------------------------

---------------------------TGTGGGC--ACATGCCATATTG-

--------AAAAACTAGGAGAAAATTAGG---ttttgggtgatggtgata

atcaa-tct-ggtc-ttactcatgcaaagtcagcactctgccaatggagc

tatat---agatccc---CA--GTCTCCAAAGGTTAGAGCGTT-------

----GAG-TGT-----CACCTT-----------------------GTAAA

CCATACTTGCTTAT--------CAC-------------------------

--------------------------------------------------

-------------------------------AGTTTCCCATTTT-AAACT

GTAACTTTG-AAACCT---GATT-GGAGAAAATT-ACTATGAAGCTATTT

G-TTGTCTTTAATTCCTGTTTGAAATAGACT----ATGTTCTGATTTTCT

GTGGATAAGTCAGAGG--CAAATACTTA----TAA---GACAG------T

TTCTGTTTCCAGATTTTCTTTTTCTGTGA---------GTGCATG-----

--------------------------------------------------

----TATTTTATTTTTAAATTCAGTGTCTATTTCTAAA---GTGCAATAG

AGCAAATGCTGAATTGGATTAT----GGGAGGTCTTCTCAGTATTAATTT

ATTCCCTGC----ACAAACACTGAGGGCCTGCTATGTTCAAGGTTCTGAC

TCAGT---AGCATAATGCAT------------------------------

--------------------------------------------------

GTTTCTATTTGACTA--TAAACGATA-CAAAGCTGTGTT------TAT--

-GTTATTCTCCCCCTA-CCCCCTTTCAG--TCAACAGGTTCTAGGGAGAA

AAACAGGCAC

>Mu

--------------------------------------------------

----------------GAA--GTAAGTA---AAATTGGTTCTGGTGGGTC

TGTGTGATAAGTGAGTCC---TGTCTTTTTGGCTGCTTTTCCTTGT----

-----------AAAACTCATTTATCACATATGAATAG---CTACGTG--C

CCATA-GTAATGTACTTTAATTTAGTGAAGTCACA--CTATCATGTAGGC

CACACGAGACATCCAT---AATTGCTACCTCTGTTAGAGTACTAT-----

--------------------------------------------------

---------GTATATTTTTAAGTTAGACTAGCTTACTGTGGGCTCATG--

-------------------------------CTGGATTGTTCAAAGA---

---------------------------------C--TATTAGTT------

------CAGA------TTGGGTT-----------ttgggtggcgctggtg

atcaaaccaagggccttatgcatgcaaagtaagccctctgccattggcac

cgtatccctagtccc---CA---------AAGGTTAGACTGTT-------

----GAG-CAT-----CACTTTTT---------------------G--AA

ACATACTT-CTTAT--------CAC----------agtttctcttatttg

tttgtctgtttatctatctatctatttatttatttatttttgagacggtt

tctctgtatagtcctggctgtcctggacttgctttgtagaccaggctggc

ctcgaactcaatagagatctacctgcttctgcctccctgagtgctgggct

taaaggcacatgccaccaggcctggct---TAGTTTCCCATTTT-AAATT

GCAACTTTG-GAAACT---GATTTGGAGAAAATT-GGTATGAGGCTATTT

A-TCATTTTTAATTCCTATTTGAAATTGATGTCA--TTATAA--TGTTCT

GTGAATAAAACAGAAG--CAGATACTAC----TTATAAGGCAG------T

TTCCGTTTTCAGGGTTGTGTGT------------------GTGTGCA---

--------------------------------------------------

--TATATTTAATTTTTAAATTCACTAGCTATTTTTAAA---GTGTAATAG

AGCAAATTCTGAATTGGATGAT----GGAATGTCTTTTCAGTATT-----

---CCCTGC----ACAAACACTGAGGGCCTGTTATGTTCAAGGTTCTGAC

TCAGT---AGCATAATGCTT------------------------------

--------------------------------------------------

GTTTCTATTTGACTG--TAAAAGTT-AAAAAGCTGTGTT----TATAT--

-GTCATTCTCCCTCTG-CCCCCTTTCAG--TCAACAGGTTGTAGGGAA--

----------

>Cc

GAGGTGGGGTGACCTTGTACAGGTGGAAAGGTATCATGCTGGAAAGTGCC

TCTCTCTCTCAGTTTGGAA--GTAAGTA---TAATTGGTTCTGGTAGGTA

TGAGTGACAAGTGACTCCTTTTTGTTTGTTTGTTTGTTTTTGTTTTGTTT

TTCCCCCTCATATAAGTGATTCATTACATATGAATAG---CTATGTG--C

CCAGA-GTAATGTGATTTAATTTAGTAACATTCCA--ATATCATGTAGAC

CACATGAGACATCCAT---AATTGCTACGTTTTTTACAGTATTA------

--------------------------------------------------

-----------------------------------------------CAC

TTT-AGATTTGTAGACATCTATTTTTTT-AAGTTAGATTTCCTTACTGTG

GG-----------------------------CTCATGCTAGATTGTT---

---------------------------CAAAGAC--TGTTAGTTT-----

------CAAC-------CAGGTT----------tttgggttgtgctggtg

atcaaatccagagccttatgcatgcaaa----------------tggagt

tatatccctagtgcc---CA---------AAGGTTAGATTGTT-------

----GAG-TTAT----CACTTT-----------------------TTAAA

ACATACTTGTTCAT--------TAC-------------------------

--------------------------------------------------

-------------------------------AGTTTTCCATTTT-AAATT

GTAACTTTG-AAAACT---GATTTGGACAAAGTT-GATATGAGGCTAT--

--TTACCTTTAATTCCTGTTTGAACTTGACTTCTCAGTTTCC--------

G-TAGAAAATCAGGCAGACTGCCTATAA----GGTGATTTCTG------T

TTAAGTTTTGTGGGTTTTGTGTGTGTGTGTGTGTGTGTGTGAGTGC----

--------------------------------------------------

-TTGTATTTCATTTTAAAATCACTG-----TTTTAAAA---ATATAATAG

AGCAAATGCTGAATTGGATTATGGAATAACTGTCTTCTCAGTATTACTGT

ATTCCCTGCACAAACACACACTGAGTGCCTACTATGTTGAAGATTCTGAC

TCAGT---AGCATAATGCAT------------------------------

--------------------------------------------------

GTTTCTGTTTGCCTG--GAAAAGTTG--AAAGCTGTGTT----TATAT--

-GTCATTCTCCCCCTG-CCCTCTTTCAG--CCAACAGGTTCTGGGGAGAA

AAACAGGCAC

>Se

GAGGTGGGGAGACCTTGTACAGGTGGAAAGGTATCATGCTGGAAAATGCC

TCTCCCTCTCAGTTTGGAA--GTAAGTA---CATTTGGTTCTGGTAGGCT

TGTGCTATAACTAAATAC---TATCTTTTTGGTTTCTTCTTCTCAT----

-----------ACATCTGATTTAATATATAGCACTAG---TTTTACG--C

TTGTA-GTAATGTACTTTTATATAGTAAAGTCCAT-GGTATTATGTAGAC

CACATGAGATATCCAT---AATTGTT-GCTTTCTTAGAGCATTAC-----

--------------------------------------------------

------------------GTTTTAGATTTGTAGACATTTTTCTGTACTAA

GGCTCACTACATTTTTTTTCTAAGTTAG---ATTAGTTTACTGTAGG---

---------------------------------C--TCATGCCAGATTGT

T-----CAGG---TTAGATTGAA-------ttgtcttggtggtttcagtg

atcaaacccagggc-ttcat-gcatacagcaagtgcgctaccaaaggagt

gatatctccagtccc---TA---------AAGGTAAGATTATC-------

---TTTTTTTTAAAAAAAAAATCTT---gccaggtgtggtggcacacgcc

ttcaatcccaggacaggggaggcgaaggcaggcagatttctgagcttgag

gccagcctggtctacatagcgagttccagaccagccagggatacatagtg

agactgctcaaaacaaacaaaaaacaaaaaaaaccccaaaccaaaacaca

---GTCAAATAACCAACCCCCCAAACCCAACTTGTTTATC----------

-------------------------------AGTTTCCCGTTTT-AAATT

ATAACTTTG-AAAACT-GTTT--GGGAGAAAATG-GATACAAGGCTCTTT

A-CCTTGTTTAATTCTTGTTTGAATTTAGCTTCA--GTCTAA--TTTTCA

GAATAGGAGGTAGGTA----GATACTAA-----GAAGACA-GA-------

TTCTATTTTTAGGCTTCTTTTGT-----------------GAGTGCAT--

--------------------------------------------------

--GGATC------TTTAAATTTAGT--ATGTTATTAAAA---TGGAATAG

ATCAAATATTGTATTGCATTATAGAATAACTGTCCTCTCAG-ATTAATGC

ATTCCCTGCA----TGTACATTGAGAGCCTGCTATATTCTAGGTTCTAAC

TCAAG---GGCATAATACGT------------------------------

--------------------------------------------------

--TTCTACTG-------TTATTACAG---AAGTTAAAAA----AAACT--

-GTTCATATGCGTTCCCCCTCCTTTTAG--TCAACAGGTTCTAGGGAGAA

AAACAGGCAC

>Jj

GAGGTGGGGAGACCTTGTACAGGTGGAAAGGTATCATGCTGGAAAGTGCC

TGTCCCTTTCAGTTTGGAA--GTAAGTA---AAATTGGTTGTGGCAGGTT

TGCCCCATGACTATATACT----TCTT---GTTTTCTCTATTCTCATC--

----------------TAATTTAATATACACCAATAG---CTATGTA--C

CTGTA-GTAACATGCTTTTATACAGTAAAGTCCCATGGTATCACATAGAC

C---ATATGAGAAATC--TAATTGACATGTTTCTTAGAGCATTCCA----

--------------------------------------------------

-------------------TATTTTTT-ATTTGTAG--------------

--------------------------------------------------

---------------------------------A-TGTTTATCTGTTTGA

T-------------------------------------------------

--------------------------------------------------

------------------GT---------ATGGCTCACTT-TC-------

--------TAA-----AATATTTT--------------------------

---------TTAAATAT-DIP-CACTTCCTAAAGTATTTTT-AAAA-DIP

-------ACACCTGGCT-AT--------CAC-------------------

--------------------------------------------------

-------------------------------AGTTTACCATGTT-AAATT

ATAACTTTGGTGATT--------GGGAGGGAATT-GGTATCGGGCTGTTT

A-CCTTCGCAAATTCTTCTTTGAACTTGGCATCA--TTGGTTCTCTGTAA

TTGAGTAAAAGGTGAA---TGGACCTAA-CAAGAAGATAGGTT-------

--CTGTTGGTGAGTTCTTTTTTT---------------GTGAGTGTACTT

TATTTT--------------------------------------------

--------------------------------------------------

TAAATTCTGTATTTTAAAAAATATC---------------------ATAG

CTCAAATAGTGTCTTGTGTTATGTAATAGCTGTTGGCTCAGTATTAATGT

GTTTCTTTC----ACAAACACTTGAGGGCTTGGCATGTTTCAGGCTCAAA

GAGGT---ATAATAAA----------------------------------

--------------------------------------------------

-------------------------------------------------T

GTTTCTGTTTTACTGCAAAAAGCT--AAAAGTCTGTGTT----AATAT--

-----------TTTTTTTTTCTTTTCAG--TCAACAGGTTCTAGGGAGAA

AAACAGGCAC

>Pca

GCGGTGGGGAGACCTTGTGCAGGTGGAAAGGTATCATGCTGGAAAGTGCC

TCTCCCTCTCAGTTTGGAA--GTAAGTA---AAATTGGTTCTGGTAGGTT

CACACTGTGGGTAAAAACTTGTCACTTT--GTTTTCTCTCCCTTAC----

-----------ACATCTGATTTAATATGTATCGACAA---CTATGTG--C

CTATA-GTAACATGCTTTTATATAGTAAGATCCCATAGTATCATGTAGAC

CACGTGGGACATCCAT---AATTGACATCTTCCTTAGAGCATTAT-----

--------------------------------------------------

-------------------GTGTTTT--AGATTCATAGACATCTAT----

-------------------------------CTATTGGTACTAAGA-CTC

ACTATTAATTTAA-------AAAGTTAGAGTAGC--TTACTTTGGACTCA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTAAGAGACCATTAGGTT---AGAT

GGTTGAA-TAT-----CACTTTT-----------------------AAAA

ACATATTTGCTTAT--------CAC-------------------------

--------------------------------------------------

-------------------------------AGTTTTCCA-TTTTGAATT

ATACCTTTT-AAAACT-TTGTTTCAGAGATAATC-AGTATCAGGCTGTTT

A-CATTCTCTAATTCCTGTTTGAACTTGGCCTAA--TTCCTA--TTTTCT

GTAAATGAATGAGAGA---TGAATACATACCACTTAGAAAACAGGTT--G

TTCTGTTTGGGGGTTCTTTTTT----------------GTGTGTGCA---

--------------------------------------------------

--TGTATTTTATTTTTAAATTCCATATCTATTTTTTTTA--ATGTAGTAA

GTCAAATATTGTATTGGATTATAGAATAGCGGTCTTCCCGCTATTAATGT

ATTCC-TTC----CACAAACATTGAGAGCCTGCCGTGTTCCAGGCTCTGG

CTAA----AGTACACAATAG------------------------------

--------------------------------------------------

-------------------------------------------------A

TTGTCTCTATTTTATTGTAAAAGCTAACAAGATATGTTGAAAAATATAG-

-----------CTTTCTTTTCTCTACAG--TCAACAGGTTCTTGGGAGAA

AAACAGGGAC

>Cgu

GCGATGGGGAGACCTTGTGCAGGTGGAAAGGTATCATGCTGGCAAGTGCC

TCTCCCTCTCAGTTTGGAA--GTAAGTACTAAAAGTGGTTCTGGTCAGTT

CATGTGATGGCTCAATACTCTTGTCTTTTTGTTTTCTCCCTCTCATAC--

-------------ATCTGATTTCTTATGTGCCGATACA--GTATGTG--C

CTATAAGTGACATGCTTTTGTATAGAAAGGGCCCGTGGTATTGTGTGGAC

CATATGGGACATCTAT---AATTGATACCTTTCTCAGAATGTTGC-----

--------------------------------------------------

-------------------ATGTTTTT-AAATATGTGGATGTTGAT----

-------------------------------CTATTTGTACTATTATTTA

CTTTT---TTAAA-------TTTT--AGAGT--ATTTTGAGCT-----CG

TAC-----------------------------------------------

--------------------------------------------------

------------------TAAATTTCTAAAAAACA--TAGGTT-------

----GATAGTTA----CTAGTTCT----------------------TGAA

ACATGTT-G-ATAG--------CAC-------------------------

--------------------------------------------------

-------------------------------AGTTTTCCATTTTGAATTG

TACCTTTTTAAATTTT-TTTTTTTAGAGAAACGC-TGTGTCACGCTGCTG

C-CATTTCCCAATTCCTATTTGAATTTGGCTTGC--TTCCCA-TTTTCTG

TAGAGGAATCAAAGATGAATAGATGCCA---CTTA--GAAGACAGGTTGT

TCTGTTTTAGAATTATTT--------------------GTGTGCA-----

--------------------------------------------------

TGGAT-CTT-ATTTTTAAATTCTATATCTATTTTTAAAT--ATGTAATAA

ATCAAATGTTGTATTGGATTACAGAATAGCTGTCTTCTCAGTACTGATAC

ATTCCCTC-----CACAAATGTTGAGGCCCTGCCATGTTTTAGGTTCTGG

CTAA----GGTACATGATGG------------------------------

--------------------------------------------------

-------------------------------------------------A

TTATCTCTATTTCACTCAATAATGTTAGCGAGCTGTGTTGAAAAAAAT--

--TGTTAATGTTTATTTTTCCTCTCTAG--TCAACAGGTTCTTGGTAGAA

AAACAGGGAT

>La

GCGATGGGGAGACCTTGTGCAGGTGGAAAGGTATCATGCTGGAAAGTGCC

TCTCACTCTCAGTTTGGAA--GTAAGTA---AAAGTGGTTCTGGTAGGTT

CGTTTGATGGCTAAATACTCTTGCCCTTTTTTTTCCCCCTCTCATACC--

--------------TCTGATTTAATATATACTAATAAG--GTATTTG--C

CTGTA-GTGATATGCTTTTGTATTGTAAGGGCCCATGGTATTGTGTAGAC

CACATAGGACATTCAT---ATTTGACACCTTTCTTAGAACATTGC-----

--------------------------------------------------

-------------------ATGTTTTT-AAGTACATAGACAT--------

-------------------------------TTATTTGTACTAATACTTA

CTATT-TTTTAAA-------AAGTT-AGCTT--ATTCTGAGGT-----CA

TGC-----------------------------------------------

--------------------------------------------------

------------------CAAATTTCTAAAAGACC---------------

----GGTAGTTT----GTTATTGTTTTC------------------TGAA

ATGTGT--G-ATAG--------CAC-------------------------

--------------------------------------------------

-------------------------------AATTT-CCATTTTGAATTA

TACCT---CCTAAGATCCTTTTTTAGAGAAAATC-TGTATCAGCCTGTTG

A-CATT-CCCAATTCCTGTTTGAATTGGGCTTGC--TTTCCA-TTTTCTG

TAAAGGAATGGAATCAGAGATGAATAGATACCACTTAAAAGACAGATTGT

TCTGTTTTAGAGTTATTT--------------------GT-TGCA-----

--------------------------------------------------

-----------------------------------------------CAC

ATGTATCTT-ATTTTTAAATTCTGTATCTATTTTTAAAA--ATGTAATAA

ATCAAATGTTGTATTGGGTTACAGAATAACTGTCTTCTCA-TACTGATAA

ATTCCCTT-----CACAAACATTGAGGGCCTGCTATGTTCTAGAGTCTGG

CTAA----GGTGCAAGATAG------------------------------

--------------------------------------------------

-------------------------------------------------A

TTGTCTGT----TTTATTCAAAAAGTTAACAAGCCCTGTTGAGAAAAT--

--TGTTAATATTACTTTGTA-TCTCCAG--TCAACAGGTTCTTGGTAGAA

AAACAGGAAC

>Ts

GCGATGGGGAGACCTGGTGCAGGTAGAAAGGTATCATGCTGGAAAGTGCC

TTTCTCTCTCTGTTTGGAA--GTAAGTA---AAATGGGTTCTGGTAAGTT

CATGCTGTGACTAAATACTCTTGCCTTTTTGTTTTCTCCCTCTCATAT--

-------------GTCTGATTTAATAGGTACCAATAAG--CTGTGAG--C

CTGTA-GTGACACGTTTTTGTATAGTAAGTTTT-ATGGTGTTGTGTAGGC

CACCTAAGACGTCTGT---AATTGACATCTTTCTTTGAACATTGCA----

--------------------------------------------------

--------------------TGTTTTT-AAATACATAGATATTTAT----

-------------------------------CTGTTTGTACTAAGACTGT

TATTT----TAAA-------AGGC--AGAGATTAATTTATTCTGGCCTCA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTGAAAGGTCATTAGGTG---AGAT

TGTTGAG-TAT-----CACTT---tttgaactcagcaatcctcctgcctc

tgtctcccgagtgctgggatatactcacaggtgtgagccaccaagcctgg

catttgtggtgtgtggtactgattgctggtgggcgtgagtcatcacacac

aatgttgtatgtggttcctgggatccaaccagggatcttgcgcctgctag

gcaggcaccggaaccactgacctaaatctccagccc--------------

---------------TGAAATGTTCTTGACTATCAGGTTTATTTTCAATT

ACACTTTCTAAGAATT-TTGTTTTAGAGAAAATT-TGTATCGAGCTGTTT

A---TATTTTTCCAGTGTGTGAATTTGGCTTGTT-TTCCAT--TTTCTGA

AAAGGAATCAG--GTAAATATATGTCA------TGTAGAAGACAAGTTGC

TCTGTTTTAAGATTATTTGTATATACACATATTTTACTTTGAATTCTGTA

ttttttttttttttttttcttttttggagacagggtctcactttgtagtt

caggctggccctgagctcactatggcgcccaggcaagccgccgcgaactc

agcaatcctcctgtctctgcctcccaagtgctgggattacaggcgtgagc

caccacgcccagcattatatgtggtaaccagggatcgaactcaggtcctt

gcgcttgcaaggcaggtgccggaaccactgagctaaccctccggccc---

TGAATTCTGTATTTTTTAAGAGTGTATTAAGTT--AAAT-----------

----------GTATTAGACTGTAGAATAGCGGTCTTCTCAGTATTAACAT

AATCTG-------CAAACAATGAGGGGCTGCT--AGCTTCTAGTTTCTGC

TTAA----GATACACAATAG------------------------------

--------------------------------------------------

-----------------------------------------------CTT

GTTTCCA--TTTTATTCCAAAAA-TCAGCAAGCTTTGTTAAAAAAATTG-

TTAATATCTCTTTTTTTTTTCTCATCAG--TCAACAGATTCTTGGTAGAA

AAACAGGGAC

>Pcu

GCGGTGGGGGGACCTTGTGCAGGTGGAAAGGTATCATGCAGGAAAGTGCC

TTTCCCTCTCTGTTTGGAA--GTAAGTA---AAATTAGTTCTGCTAAGTT

CATGCTGCGACTAAATACTCTTGCCTTCTTGTTTTCTTCCTCTCATGT--

-------------GTCTGATTTAATAATTAC-AATAAG--TGATATG--C

CTGCT-GTGACAAAGTCCCA-----------TGACATTGTGTAGCTAGAC

CACCTATGGCATCTGT---AACTGACGTCTTTCTTTGAATGCTGC-----

--------------------------------------------------

-------------------ATGTGTTT-AAATACATATA-----------

-------------------------------CGTATTGTACTAAGACTTA

CTATTCC-TTAAA-------AAGGT-AGAGTTTAGTTTATTCTGGGTTCA

AAC-----------------------------------------------

--------------------------------------------------

------------------CAAGTTGCTAAAAGGTTAGATTGTT-------

----GAA-TAT-----CACATTTTGAAATGTGTTT---------------

--------------------------------------------------

-------------------------------GATTATCAGTTTTCAA-TT

ATACTTACTAAGAACT-TTATTTTAGAGAAAAACCTGTATCAGGCTGTTT

A-CATTCTCCCATTCCTGTTTGAATGGAGCTTG-TTTTCCC--TTGTTG-

--GTACGTGAGTC--AGGTGAATTGATA--GCACCCAGGAGATAGGTTGT

TCTGCTGTAGGATTATTTGT-------------------ATGTGCATGTA

TAGCATTTTTAAAAAAATTTTGC---tttattttttatggccggctcagc

ctgccctgggggcagggctggcgcagcatgtggtgccggggatcaaaccg

tggtccctgcggttgcaactttcctaagcaggcgctttagaccactgagc

catcccaccagcccc-----------------------------------

--------------------------------------------------

ATGTA--TAGCATTTTAAAATCTCATATGTTTTAAAAA---ATGAATTAA

GTCAAACATTGTATTAGATTACACAATAACTGTCTTCTCAGTACTCATAT

GAATCAGTCTT--GCAAACAGTGAGGGCCTGTCAGGTTCTTGGTTTTGGT

TAAT----GTGCAATAGATT------------------------------

--------------------------------------------------

GTTTCTTGTTTATTCC---AAAAGTTAACACACTATGTTGAAAAAAAT--

--TACTAATATTTCTTTTTTCTCTTCAG--TCAGCAGATTCTTGGTAGGA

AATCAGCGAT

>Mc

GCGGTGGGGGGACCTTGTGCAGGTGGAAAGGTATCACGCAGGAAAGTGCC

TTTCCCTCTCTGTTTGGAA--GTAAGTA---AAATTAGTTCTGCTAAGTT

CATGCAGCAAGTAAATACTCTTGCCTTTTTGTTTTCTTCCTCTCAT----

-----------GTGACTGATTTAATACTTACCAATAA----GTGATGTGC

CTGCA-GTGACAAAGTCCTG--------------TGGCATGTAAATAGAC

CACCTATGGCATCTGT---AACTGATATCTTTCTTTGAATGCTGC-----

--------------------------------------------------

-------------------ATGTGTTT-AAATACATATA-----------

-------------------------------TGTATTATACTAAGACTTA

CAGTT---TTAAA-------ACGGT-AGAGTTTA-----TTCGGGGTTCA

AAC-----------------------------------------------

--------------------------------------------------

------------------CAAGTTGCTAAAAGGTTAGATTGTT-------

----AAA-TAT-----AACATTTTGAAATG--------------------

--------------------------------------------------

-------------------------------TGTTTATCAGTTTTCAGTT

ATACTTCCTAAGAACG-TTGTTTTAGAGAAAAACCTGTATCAGGCTGTTT

A-CATTCTCTAATTCCTGTTTGAAGGGAGCTTCT--TTTCCA-TTGTTGG

T---AAATGAGTCAGG--TGAATTGATA-GCACCC-AGGAGACAGGTTGC

TCTGCTTTAGGATTATTTGT-------------------ATGTGC-----

--------------------------------------------------

ATGTA--TAGCATTTTAAAATCTTATGTGTTTTAAAAC---ATGAATTAA

GTCAAACACTGTATTAGATTACACAATAGCTGTCTTCTCAGTACTCATAT

GAATCAGTCTT--GCAAACACTGAGGGCCTGCCAGGTTCTAGGTTTTGGT

TAA-----TGTACAATAGA-------------------------------

--------------------------------------------------

----------------------------------------------TTGT

TTCTTTATTC-------CAAAAGTTAACACACTATGTTG--AAAAAAT--

--TATTAATATTTCTTTTTTCTCTTCAG--TCAACAGATTCTTGGTAGGA

AAGCAGGGAT

>Cp

GCGGTGGGGGGATCTTGTGCAAGTGGAAAGGTATCACGCAGGAAAGTGCC

TTTCCCTTTCTGTTTGGAA--GTAAGTA---AAATTGGTTCTGCTAAATT

CATG--AGTACTCTGCC-------TTTTTTGTTTTCTCCCTCTCATGC--

-------------ATCTGATTTAATATTTGCCAATAAG--TGATGTG--C

CTGTA-GTAACAAAGTCCCA---------------TGACACTCTGTAGAC

CACCTGAG--ATCCGT---AACTGACATTTTTCTTTGAACATCAC-----

--------------------------------------------------

-------------------ATGTGTTT-AAATACATAGATGTTTAT----

-------------------------------CTGTTTGTACTAAGATTTA

CTATTCC-TTAAA-------AGGGT-AGAGATTAGTTCATTCTTGGCTGA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTAAAAGATTAGATTGTT-------

----GAG-TAT-----CACTATTTTTTGCTTTTTTTTGTACCACTTTTTG

AAATGTATTTGATTATC---------------------------------

--------------------------------------------------

-------------------------------AATTTCCCATTTTTTAATT

ATACTTTCTAAGAACT-TTGTTTTAGAGAAAATC-TGTATCAGGTTATTT

A-TACTGTCCAATTCCTGTTCAAATGTGGCTAATT-TCCCAA-TTTTTTG

T----AGGGAATCAAG--TGAATAGATA-GCACCT-AGAAGATAGGTTGC

TCTGCTTTATAATTATTCGT-------------------ATGTGCAT---

--------------------------------------------------

--GTGTC--TTATTTTAAATTCTATATCTGTTTTTAAA--AATATATTTA

GTCACACATTGTGTTAGGTTACAGAATAGCTGTCTTCTCAGTATTAATAT

AATCTCTT-----ACAAACAATGAGGGCTTGCCTGGTTCTAGATTCTGGT

TAAGA---TGCCCAATAGCA---ggctggggacttagctcagcagcataa

gcacttgcctggcaagcgtaaagtcatgagtttgatccctagtaccaaaa

catagaataataaagaga-----------TGCCCAATAGATTA---TTTC

TCTTTTATTCCC-------AAAGTTAACAAGCTATGTTAAAAATAAAT--

--TGTTAATATTTCTTTTTTCTCTTCAG--TCAACAAATTCTTGGTAGAA

AAACAGGGAC

>Dp

GCGGTGGGGGGACCTTGTGCAAGTGGAAAGGTATCATGCTGGAAAGTGCC

TTTCCCTTTCTGTTTGGAA--GTAAGTA---AAATTGGTTCTGCTAAATT

CATG--AGTACTCTTGCC------TTTTTTGTTTTTCCCCTCTCATGC--

-------------ATCTGATTTAATATTTGCCAATAAA--TGATGTG--C

CTGTA-GTGACAAAGTCCCAT---------------GGCATTCTGTAGAT

TACCTGAGATC--CCT---AACTGACATTTTTCTTTGAACATCGCC----

--------------------------------------------------

-------------------ATGTGTTT-AAATACATAGATGTTTAT----

-------------------------------CTGTTTGTACTAAGACTTA

CTGTTCA-TTAGA-------AGGGT-AGTAGTTAG----TTCTGTGCTGA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTAAAAGATTAGATTGTG-------

----GAG-TAT-----CACTTTTTTTCCTTTTTTTAAATATCATTTTTTG

AAATGTACTTGATTACC---------------------------------

--------------------------------------------------

-------------------------------AGTTTCCCATTTTTCAATT

ATACTTTCTAAGAACT-TTGTTTTAGAGAAAATC-TGTATCAGGTTATTT

A-TATTCTCCAATTCCTGTTTGAATGTGGCTTGTT-TCCCATTTTTTTGG

T---AAGGGAATCAAG--TGAATAGATA-GTACCT-AGAAGACAGGTTGC

TCTGCTTTAGAATTATTTGT-------------------ATGTGCAT---

--------------------------------------------------

--GTGTC-TTATTTTTAAATTCTATATCTGTTTTAAA--AAATATATTGA

GTCACACATTGTGTTAGGTTACAGAATAGCTGTCTTCTCAGTATTAATAT

ACTCTCTT-----ACAAACAATGAGGGCTTGCCCGGTTCTAGATTGTGGT

TAAGA---TGTCCAATAGCG---ggctggggacttagctcagcagcataa

gcgcttgcctggcaagtgcgaggtcatgagtttgatccccagtaccaaaa

aaataaaataaaaaaaaataaaaaga---TGCCAAATAGATTA---TTTC

TCTTTTATTC-------CCAAAGTTAACAAGCTATGTTAAAAATAAAT--

--TGTTAATATTTATTTTTTCTCTTCAG--TCAACAAATTCTTGGTAGGA

AAACAGGGAC

>Cop

GCGATGGGGGGACCTTGTGCAGGTGGAAAGGTATCACGCTGGAAAGTGCC

TTTCCCTCTCTGTTTGGAA--GTAAGTA---AAATTGGTTCTGCTAAGTT

CATACTGTGACTAAATACTCTTGCCTTTTTGTTTTCTCCTTCTCATAC--

-------------ATCTGATTTAATATTTACCAATAAG--CGATGTG--C

CTATA-GTGACATAGTCCCA---------------GGGCATTGTGTAGAC

CACCTGAGGCATCTGT---AACCGACATCTTTCTTTGAATGTTGG-----

--------------------------------------------------

-------------------ATGTGTTT-AAATACATAGATGTTTAT----

-------------------------------CTGTTTGTACTAAGACTTA

CTGTTCCCTTAAA-------AAGGT-AGAGATTAGTTTATTCTGGGCTCA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTAAAAGGTTACATTGTT-------

----GAG-TAT-----CACTTTTTGAAAAGTGCTTGATTATC--------

--------------------------------------------------

-------------------------------AGTTTTCCA-TTTTCAGTT

ATATTTTCTGAGAACT-TTGTTTCAGAGAAACTC-TGTATCAGGCTGTTT

A-CATCCTCCAATTCCTGTTAGAATGTGGCTTGT--TTCCCA-TGTTCTG

T---AAAGGA--GTCAGGTGAATAGACA-GCACCT-AGAAGACAGGTTGC

TCTGCTTAGT-ATTATTTGT-------------------ATGTGCAT---

--------------------------------------------------

--GTATCTTATTTTTTAATTCTGTATCTGTTTTTAAAA---ATGTATTAA

GTCAAACATTGTATTAGATTACAGAATAGCTGTCTTCTCAGTATTAATAT

AATCTCCT-----GCAAACAATGAGGGCCTGCCAGGTTCTAGGTTCTGGT

TAAGA---TGCAGATAGTTT------------------------------

--------------------------------------------------

-------------------------------------------------C

TCTTTTATTC-------TAAAAGTTAACGAGCTATGTTG-AAAAAGAT--

--TGTTAATATTTCTTTTTTCTCTTCAG--TCAACAGATTCTTGGTAGAA

AAACAGGGAT

>Sv

GCGGTGGGGAGACCTTGTGCAGGTGGAAAGGTATCATGCTGGGAAGTGCC

TCTCCCTGTCCGTTTGGAA--GTAAGTA---AAATTGGTTCTGGTGGGTT

TGTGCTTTGAGTACTC-----TTTTATCTTCTCTCTCTCATGTCTGAC--

--------------------TTAATATATACTAAAAAT---CATGTG--C

CTGTA-CCAACTTGCTTTTGTTTAGTCATTCATGCTAGGTCAGCACTGAG

CCA--------TATCCCCAACCTCACATCTTTCTTAGAACATTAC-----

--------------------------------------------------

-------------------ATGTTT--CAGATCCATAAACATTTAT----

-------------------------------CTGTTTGTATTAAGACTTA

ATATTTTTTAAAA-------ACTTA-AGGTT--AGTTTACTCTAGATTCA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTAAAAGACCATTAGATT-------

----AGATTGG-----TGAGTATCTGTTTTTTTTTT-----------TTA

ACATGCTTGCTTATCAC---------------------------------

--------------------------------------------------

-------------------------------AGTTTTCTGTTTTGAATTA

TACCTTTTTAAAAACT-TTGTTTTGGAGAAAATC-AGATATCAGACTGTT

TATATTCCCCAATTCCTCTTTGAACTTTGCTTGA--TTCCCA-TTTTCT-

--CCAAAGGAATTAGAGG------------TGAAT-AGATAG-ATACCTC

TTGGAAGACAGGTTTTTCT--------------------GTTCTTTCTT-

--------------------------------------------------

--GATTATTC-------AGAA-GTT---AAGCTGTGTTG---AAAAAT--

TTTTTTAATATTTTTTTTCTCTCTTAAG--CCAACAGGTTCCTGGTAGAA

AAACAGGAAC

>Mma

GCGGTGGGGAGACCTTGTGCAGGTGGAAAGGTATCATGCTGGAAAGTGCC

TCTCGCTGTCTGTTTGGAA--GTAAGTA---AAATTGGTTCTGGTAGATT

TATGCTTTGATTAAATAC--TCTTTTTTATTTTCTCTCTCTCTCATA---

------------TGTCTGACTTAATATATACTCATAATGAGTATGTG--C

CCATG-GTAACTTGCATTTGTATAGTCATACATGCTAGGTAAGCACTCTA

CCACTGAGCTATATCCCCAACCCCACGCCTTTCTTAGAACATTGC-----

--------------------------------------------------

-------------------ATGTTT--CAGATCCATAAACATTTAT----

-------------------------------CTGCTTATATTAAGATGTA

CTATTTTTTAAAA-------TCTTA-AGGTT--AGTTTACTCTAGAGTCA

TAC-----------------------------------------------

--------------------------------------------------

------------------CAAATTGCTAAAAGACCATTAGGTT-------

----AGGTTGT-----TGAGTTTTTTTTTTTTTTTT------------AA

ATATGTTTGCTTAGCAC---------------------------------

--------------------------------------------------

-------------------------------AGTTTTCTGTTTT-CAATT

ATACCTTTTAAAAACT-TTGTTTGGGAGAAAAT-----------------

--CAGATATCAAGCTGTGTTTGAACTTTGCTTGA--TTCCCA-TTTTCT-

------CTAAAGGAGAAG------------TGAAT-AGATA---------

-CTGCTTAGA-AGACAGGTTTTTCTGTT-----------TTAGAGTTATT

TTTT----------------------------------------------

--------------------------------------------------

--GATTATTC-------CAAAAGTT---AAGCTGTGTTG-----AAATTT

TTTTTTAATATTTCTTTTTTCTCTTCAG--TCAACAGGTTCTTGGTAGGA

AAACAGGATC

>Gg

GCGATGGGGAGACCTTGTACAGGTGGAAAGGTATCATGCTGGGAAATGCC

TCTCCCTGTCAGTTTGGAA--GTAAGTA---AAATTGGTTCTGGTAGGCT

CATGCCGTGACTAAACAC---TTTTCATTATTTTTCTCTCATACATCG--

-----------------GATACAATATATGCCAACGTC---TATGTG--C

CTATA-GTAACGTGCTTTTGTATAGTAAGATCCCATAGAATCACATAGGC

TACA---TGGGACATCTATAATTGACACCTTTCTTAGAACATTCC---tt

ttttttttttacagtactggagatggaacccaggggcattctgcctccaa

gctacacccccagccc---TATTTCTTATTCTTTA---ttttgaaacagg

gtctcactaagttgcggagggcctcactaagtaactgaggctgaccatga

acctgcgatcctcctgtctcagcctcccaagtactgggattacaagcgtg

cgccaccactcctggc---A-GTTTT-CCA--------------------

--------------------------------------------------

----------------------------------------TTTTGAATTA

CACCTTTTGC-AAACTTTCTT---GGAGAAAATC-AGTATCAGACTGTTT

A-T-GTTCCCAATTCCTGTTTGAACTTTGCTTGA--TTCCCATTTTTCT-

---TTAATGGACTCAGAGGTGAATAGATACTACTT-AGAAGACAGGTTGT

TCTGTTTTGGAGGTTTTGTTTTATT--------------TTAACTTTTAA

AT------------------------------------------------

--------------------------------------------------

-TCTATGCCCATTTT-----------------TTAAAA---TGTAATAAA

TCAAATACTGGATTA-----TAGAATAGCTGTCTTCCCAGTATTAATGTA

TCCCATCC-----ACAAACATTGAGGGCCTGACATGTTCCAAGCTCTGGC

TAAGG---TGCAAAATAGAT------------------------------

--------------------------------------------------

--------------------------------------------TGTCTC

CATTTTATTC-------CAAAAGTTAAGAAGCTGTGTTGAAAGAAAAT-T

CTTAATGTTTCTTTTTTTTTCTCTTTAG--TCAACAGGTTCTTGGGAGAA

AAACAGGGAC

>Oc-TDB

GCGGTGGGGAGACCTTGTGCAGGTGGAAAGGTACCATGCTGGAAAGTGCC

TCTCTCTCTCAGTTTGGAA--GTAAGTA---ATATTGATTCTATTATGTT

CATGCTATGACTCTAAATAC--TTTCTCTCTTTTTCTCTCATATATCT--

-----------------GATGTAATACATACCAGAACT--AAGTGGG--A

CAAAC-ATAACGTACACCTC-----------------TCTTAGAACATGG

CATGCTTTGAATACAAGTACATTTATCTGTTGTTCCAAGACTTAC-----

--------------------------------------------------

-------------------TATTCTTAGAAAATTTGAGAGATTAGTTTA-

-------------------------------CTCTGGGCTCATACCA---

-----AATTGCGA-------AAGACATTAGGGTAGAGTGTGGG-------

--------------------------------------------------

---------------------------------TATCATTTTT-------

----TTAAAC----------------------------------------

--------------------------------------------------

-------------------------------ACTTTTCACAGTT--GT-C

TATTTT-----------------------------GAATCATCCTCTTAA

TAATCCTCGATTCCTCTGCTAGAAGTTTGCTTCA--TTCCCA-TTTTCTG

T---AAAGGA--GTCAGGGGAAGAGGTA-CCACTT-AGGCCACAAGTTTT

ATTTTGGGG---TTCTTTAGT------------------GTGTGGAT---

--------------------------------------------------

--GTATTTTATTTTTAAATTGTATATGTGTTTTTTTA----GTGCAATAA

GTCAGATATTGTATTGGGTTACAAAATAGCTGTTTTCCTAATATTAACTT

AATCCTTCC----GTAAACATTGAGGGCCTGTCATGTTCCATGCTCTGAG

AAAGC---TACACAATAGG-------------------------------

--------------------------------------------------

-------------------------------------------------T

TATTTTATTC-------CAAAAGT--------------------AATTAC

TTGTTAATATTTCTTTTTTTCTCTTTAG--TCAGCAAGTTCTTGGGAGAA

AAACAGGGAT

SI APPENDIX

Sequencing of Nuclear and Mitochondrial Genes: Taxon Sampling

The taxon sampling represents all major lineages of rodents and two representatives of the Laotian rock rat (Laonastes aenigmamus). Laonastes samples were collected between 1998 and 1999 in the Khammouan Province, Lao People's Democratic Republic (PDR) and conserved as described (1).

All suborders and super families of the order Rodentia recorded by Carleton and Musser (2) are included in the analysis, including representatives of 24 of the 34 rodent families. Fewer families belonging to the superfamilies Muroidea and Caviomorpha are included because they have been shown to be monophyletic (3, 4).

The tree was rooted with the closest rodent outgroups: the lagomorphs, the primates, Cynocephalus (flying lemur), and Tupaia (tree shrew). Together with rodents, the lagomorphs, the primates, the flying lemurs, and the tree shrews form a clade called Euarchontoglires or Supraprimates (5-8). For the molecular dating analysis we also added one additional outgroup, the dog (Canis familiaris), which is a representative of the Laurasiatheria. Laurasiatheria (e.g., carnivores, artiodactyls, bats, horses) has been shown to be the sister clade of Euarchontoglires (5-8).

DNA Amplification and Sequencing

DNA Isolation. The total DNA of two Laonastes specimens were extracted with two different kits: the QIAamp DNA mini kit (Qiagen) and the Puregene DNA isolation kit (Gentra System). Both methods yielded good results, and the DNA extracts obtained with the two methods were pooled for each individual.

Ethanol-preserved samples of other rodents were obtained from the mammalian tissue collection of the Institut des Sciences de l'Evolution de Montpellier (9) or the Molecular Systematics collection of the National Collections of Natural History (Tel Aviv University). Total DNA of other rodents was extracted by using either the QIAamp DNA mini kit (Qiagen) or according to Sambrook, Fritsch, and Maniatis (10) with slight modifications.

PCR Amplification and Sequencing. Four nuclear genes and two mitochondrial genes were considered. The nuclear genes code for the alpha 2B adrenergic receptor (ADRA2B), the growth hormone receptor (GHR), the interphotoreceptor retinoid binding protein (IRBP), and the von Willebrand factor (vWF). The mitochondrial genes code for the cytochrome b apoenzyme (cyt b) and the small ribosomal subunit RNA (12S rRNA).

The nuclear genes were chosen for the following reasons (i) A large number of the sequences are already available, especially within rodents, and these genes have been shown to contain phylogenetic information within rodent and between mammalian orders (4, 5, 11) (ii) The four genes ADRA2B, GHR, IRBP, and vWF are not genetically linked; their location is variable, on chromosomes 2, 15, 14, and 6 in Mus, chromosomes 3, 2, 16, and 4 in Rattus, and chromosomes 2, 5, 10, and 12 in Homo (iii) The proteins they encode do not display any biological interaction or functional relation: ADRA2B is an adrenergic receptor expressed mainly in the kidneys, GHR is a transmembrane receptor for growth hormone, IRBP is located in the matrix of the retina, and the vWF protein is a blood coagulation factor. The mitochondrial genes were chosen because they provide independent markers when compared with the nuclear genes. These markers have also been used previously to understand rodent relationships (12, 13) although they have been shown to contain less phylogenetic signals than nuclear genes (14). Cytochrome b and the 12S rRNA are also the markers used by Jenkins et al (1) and could thus be used for comparison with their study. The properties of the six genes also allowed us to combine them in a single large data set, in which the potential influence of any contrasting evolutionary properties of each individual gene is moderated, and thus to obtain a more reliable estimation of the phylogenies and datings.

To test the reproducibility of the phylogenetic results, the sequencing of two Laonastes individuals was performed in three different laboratories (each laboratory sequencing two genes). P.C. sequenced the GHR and the IRBP genes in France, D.H. sequenced the ADRA2B and the vWF genes in Israel, and C.W.K. sequenced the cyt b and the 12S rRNA genes in the United States.

In addition, to reduce the amount of missing data when combining different genes, the ADRA2B, GHR, IRBP, vWF, cyt b and 12S rRNA genes were sequenced for additional rodent species. Thirty-eight new sequences were thus included in the analysis.

Amplification of the Four Nuclear Genes. dsDNA was amplified in 25-μl volume reactions. Different PCR conditions were used for each gene.

ADRA2B.PCR amplifications of the ADRA2B gene were performed according to Poux et al (15): 94°C denaturation (2 min); 35 cycles of 94°C denaturation (1 min), 50-60°C annealing (1 min), 72°C extension (1 min, 30 s); and a final extension of 72°C (10 min).

GHR.Exon 10 of the GHR gene was amplified by using the following parameters: 95°C (5 min); 5 cycles of 95°C (30 s), 61°C (30 s), 72°C (1 min); 5 cycles of 95°C (30 s), 59°C (30 s), 72°C (1 min); 5 cycles of 95°C (30 s), 57°C (30 s), 72°C (1 min), 5 cycles of 95°C (30 s), 55°C (30 s), 72°C (1 min); 20 cycles of 95°C (30 s), 53°C (30 s), 72°C (1 min); and a final extension of 72°C (10 min).

Table S1. Primer sequences

Gene	Primer name	Primer utility	Sequence (5'-3')	Source
ADRA2B	A2ABFOR	External	asccctactcngtgcaggcnacng	16
	A2ABREV	External	ctgttgcagtagccdatccaraaraaraaytg	16
	AD2	Reamplification	AGTACAACTCCAAGCGCACNCC	Unpublished
	AD3	Reamplification	TGATCGCCAARCGCAGCMACYGC	Unpublished
	AR2	Reamplification	GGTGTCCATTGGCCTCTC	Unpublished
	AR3	Reamplification	CGYTTGGCAATCASGTARAT	Unpublished
	A2	Reamplification	GAGTACAACTCCAAGCGCAC	Unpublished
	B2	Reamplification	GGCTTGGGGTGTCCATTRGCCTC	Unpublished
	B4	Reamplification	GCTGCGYTTGGCAATCAGGTAGATGCG	Unpublished
GHR	GHR1	External	GGRAARTTRGAGGAGGTGAACACMATCTT	11
	GHR2	External	GATTTTGTTCAGTTGGTCTGTGCTCAC	Unpublished
	GHR7	External	AAGCTGATCTCTTGTGCCTTGACCAGAA	Unpublished
	GHR8	External	TTGGCATCTGACTCACAGAAGTAGG	Unpublished
IRBP	IRBP217	External	ATGGCCAAGGTCCTCTTGGATAACTACTGCTT	17
	IRBP1531	External	CGCAGGTCCATGATGAGGTGCTCCGTGTCCTG	17
	J1	External	CCACTGCCCTCCCATGTCTG	18
	ID2	Reamplification	TCCTGGAGGGCAACGTGGGCT	Unpublished
	I2	Reamplification	ATCCCCTATGTCATCTCCTACYTG	18
		/external
	IR3	Reamplification	cagcttctgaaggtccagggc	Unpublished
	J2	Reamplification /external	TTGAGCTTGGTGACCAGRTCCTC	18
vWF	VD1	External	GTGTCAACCTYACCTGTGAAGCNTG	Unpublished
	VR1	External	TGCAGGACCAGRTCAGGAGCYTC	Unpublished
	VD2	Reamplification	GAGAAGCAGGCCCCTGARAACAA	Unpublished
	VD5	Reamplification	GGAGGCCTGGHRGTGCCCCC	Unpublished
	VD5L	Reamplification	GACCCCAAGACCTGGTGATGCC	Unpublished
	VR4	Reamplification	GAACTCCTTGCTCYTGTTGAAGTT	Unpublished
	VR6	Reamplification	AAGTCCTGGATGAAGATGGG	Unpublished
Cyt b	L-14115	External	GATATGAAAAACCATCGTTG	19
	H-14541	External	CAGAATGATATTTGTCCTCA	19
	H-14949	External	GGCAAATAGGAARTATCATTC	20
	L-14953	External	CCCCCAGCACATATTAAACCAGAATG	20
	H-15309	External	CTGCAGTCATCTCCGGTTTACAAGAC	21
	H6	External	TCTCCATTTCTGGTTTACAAGAC	13
	L7	External	ACCAATGACATGAAAAATCATCGTT	13
12S rRNA	L-509	External	AACTGGGATTAGATACCCCACTAT	22
	H-901	External	AAGAGCGACGGGCGATGTGT	22
	R1	External	AAAGCAAGGCACTGAAAATGCCTAGA	23
	S2	External	TCTTCTGGGTGTAGGCCAGATGCTTT	23

IRBP. Exon 1 of the IRBP gene was amplified by using the following parameters: one cycle at 94°C denaturation (5 min), 50°C annealing (45 s), 72°C extension (1 min 30 s); 34 cycles of 94°C denaturation (45 s), 50°C annealing (45 s), 72°C extension (1 min 30 s); and a final extension of 72°C (15 min).

vWF.PCR amplifications of exon 28 of the vWF gene were performed according to Huchon et al.(24): one cycle of 94°C denaturation (5 min), 50-60°C annealing (1 min), 72°C extension (2 min); 30 cycles of 94°C denaturation (45 s), 50-60°C annealing (45 s), 72°C extension (2 min); and a final extension of 72°C (15 min).

External primers for amplifying the ADRA2B, IRBP, and GHR genes are described in Springer et al (16), Stanhope et al (17), Poux and Douzery (18), and Adkins et al (11). Primers for the vWF gene were newly designed using sequence information from recently published complete genomes of mammals (Table S1). When the amount of amplified DNA was insufficient for direct sequencing, smaller overlapping DNA fragments were obtained either by direct amplification or reamplification of the initial PCR product. Reamplifications were performed by using 2 μl of the initial PCR and one external and one internal primer (nested PCR). Primers used for amplifications and reamplifications are indicated in Table S1. The gene sequences were then obtained based on two or more overlapping fragments. The gene fragments amplified for each species are indicated in Table S2.

Amplification of the Two Mitochondrial Genes. Cyt b and 12S rRNA genes of Laonastes were amplified in fragments by using the following parameters: 35 cycles of 94°C denaturation (1 min), 50°C annealing (1 min), and a final extension of 72°C (1 min, 10 s). Amplification reactions were performed in 25-μl volumes by using puReTag Ready-to-Go PCR Beads (Amersham Pharmacia Biosciences) and 1.0 μM of each primer. Amplification of cyt b was accomplished with the use of primers [numbered in reference to Mus (25)] L-14115, H-14541 (19), H-14949, L-14953 (20), and H-15309 (H-15915) (21). A fragment of the 12S rRNA gene was amplified with primers L-509 and H-901 (22) (Table S1).

Amplification of cyt b and 12S rRNA genes of other rodents were performed under the same conditions: one cycle of 94°C denaturation (5 min), 50°C annealing (45 s), 72°C extension (1 min 30 s); 34 cycles of 94°C denaturation (45 s), 50°C annealing (45 s), 72°C extension (1 min 30 s); and a final extension of 72°C (15 min). External primer pairs used for amplifying the complete cyt b and 12S rRNA genes are described in Montgelard et al.(13) and Sourrouille et al (23) (Table S1).

Purification of the PCR Products and Sequencing. Double-stranded PCR products were purified either by PEG precipitation (10) or from 1% agarose gels using Amicon Ultrafree-DNA columns (Millipore). Samples were sequenced with a Big Dye Terminator Cycle Sequencing Kit on an ABI PRISM 3100 or on an ABI PRISM 373 Genetic Analyzer (Applied Biosystems). Additional sequencing primers were designed when required to provide overlapping sequence coverage on both strands for the entire region considered.

All sequences have been deposited in GenBank (accession nos. AM407897-AM407933; DQ139933). Accession numbers of the 38 newly obtained sequences are available in SI Table 2.

Table S2. Origin of the tissue samples considered, and genes amplified

Tissue no.	Species	Origin	Country	Donor/collector	Gene sequenced (fragments reamplified)
T-1703	Tachyoryctes sp.	Cell culture	Buhanza, Burundi.	V. Volobouev / E. Pelé	12S rRNA (R1-S2)
DH X -039	Spalax erhenbergi	Tel-Aviv University, colony	Israel	J. Terkel	ADRA2B (A2ABFOR-AR2; AD2- A2ABREV)
T-0869	Dipus sagitta	___	Caucasus, Russia	P. Gambarian	GHR (GHR1-GHR8; GHR7-GHR2), Cyt b (H6-L7)
T-0552	Jaculus jaculus	___	Djoudj, Senegal	J.-M. Duplantier	ADRA2B (A2ABFOR-B4; A2-A2ABREV)
Hair sample	Jaculus jaculus	Tel-Aviv University, colony	Israel	D. Eilam	IRBP (IRBP217-IR3; ID2-IRBP1531)
T-1220	Glis glis	___	Forel, Switzerland	F. Catzeflis	GHR (GHR7-GHR2)
T-1730	Thomomys bottae	___	San Bernardino, California, USA	J. L. Patton	GHR (GHR1-GHR4), 12S rRNA (R1-S2)
T-1904	Geomys breviceps	Louisiana State University Museum of Natural Science	Vermon Parish, Louisiana, USA	D. L. Dittmann / D.S. Semple	ADRA2B (A2ABFOR-B2; A2- A2ABREV), IRBP (IRBP217-J2; I2- IRBP1531), vWF (VD1-VR4; VD5-VR1)
T-0137	Marmota monax	___	Yukon, Canada	R.S. Hoffmann	GHR (GHR1-GHR8)
T-1758	Sciurus aestuans	___	Petit saut, French Guyana	T. Arrizabalaga	vWF (VD1-VR6; VD5-VR1)
T-1787	Anomalurus sp.	___	Djoum, Cameroun	J.-C. Gautun	GHR (GHR1-GHR4, GHR7-GHR2)
___	Pedetes capensis	___	South Africa	C. Matthee	ADRA2B (A2-A2ABREV)
T-0390	Massoutiera mzabi	Colony in Lyon, France	Mzabe, Algeria	P. Gouat	GHR (GHR1-GHR2)
___	Ctenodactylus gundi	Colony Zoo Landau, Germany	___	S. Honigs	ADRA2B (A2ABFOR-AR2; AD2- A2ABREV)
T-0374	Ctenodactylus vali	___	Taglut, Algeria	P. Gouat	IRBP (I1-J2, I2-J1)
BMNH 1998.25	Laonastes aenigmamus	___	Lao PDR	M. Robinson	ADRA2 (A2ABFOR-AR2; AD3- A2ABREV; AD2- A2ABREV), IRBP(1I-J2; I5-J1), GHR(GHR1-GHR8; GHR7-GHR2), vWF (VD1-VR4; VD2-VR1), 12S rRNA (L509-H901), Cyt b (L14115-H-14949; L14953-H15309)
BMNH 1998.410	Laonastes aenigmamus	___	Lao PDR	R. Timmins	ADRA2 (A2ABFOR-AR3; AD3- A2ABREV; AD2- A2ABREV), IRBP(I1-J2; I5-J1), GHR (GHR1-GHR8; GHR7-GHR2), vWF (VD1-VR4; VD5L-VR1), 12S rRNA (L509-H901), Cyt b (L14115-H14541; L14953- H-15309)
T-1848	Heterocephalus glaber	___	Kenya	C. Faulkes	ADRA2B (A2-A2ABREV; 2ABFOR-B2), IRBP (IRBP217-J2, I2- IRBP1531)
T-2119	Capromys pilorides	Rotterdam Zoo (Netherland)	___	M. Mensink	ADRA2B (A2ABFOR-B2, A2- A2ABREV), IRBP (IRBP217-IRBP1531)
T-1052	Octodon degus	___	Parc national Fray Jorge, Limari, Chili	L. Contreras	GHR (GHR1-GHR4; GHR7-GHR2), Cyt b (H6-L7), 12S rRNA (R1-S2)

SINE Presence/Absence Analyses

A novel computational strategy CPAL (Conserved Presence/Absence Locus-finder) was used to find 16 phylogenetic informative loci with clear presence/absence patterns of transposed elements in rodents (26). We then attempted to PCR amplify the 16 phylogenetic informative loci from Laonastes genomic DNA. PCR conditions were as follows: initial denaturation at 94°C for 4 min, followed by 35 cycles of denaturation (94°C, 30 s), annealing at primer specific temperature (Table S3) for 30 s, and polymerization at 72°C for 1 min. The PCRs were completed after 5 min at 72°C.

Eleven of the 16 loci were amplifiable in Laonastes (Table S3). PCR products were purified by agarose gel electrophoresis, ligated into the pDrive Cloning Vector (Qiagen, Hilden, Germany), and electroporated into TOP10 cells (Invitrogen, Groningen, The Netherlands). The products were then sequenced with the Ampli TaqFS Big Dye Terminator Kit (PE Biosystems, Foster City, CA) using the M13 forward (5'-CCCAGTCACGACGTTGTAAAACG-3') and reverse (5'-AGCGGATAACAATTTCACACAGG)-3' primers.

All derived sequences were aligned against and compared with available sequences from 22 rodent species (26) to ascertain the presence and/or absence of the various SINE markers. Alignments in FASTA format are presented in SI Data Set.

Table S3. Mouse genomic locations, primers, accession numbers, and diagnostic SINEs.

Locus	GI-no.	Coordinates (GI-no.)	Chromoosome	f = forward primer 5'-3' orientation r = reverse primer	Annealing,C	Accession nos.	Diagnostic SINEs
1	24371378	1209 - 1623	1qC5	1f CCGCCTAYCTSTGYGGGGTCAA 1r TGTGTGCGMGTAGGTRCCGGCT	57	La: EF052254	1-B1
2	20513267	8588 - 9130	17qB3	2f CAGCCATYGTCCTTTTCACCAG 2r CCAGACCCWCCATTRGAGAGTGA	58	La: EF052255	2a-B1
							2b-B1
							2c-ID2
							2d-B1
							2e-B1-dID
5	2344862	8570 - 9595	19qA	5f GGAGGGGCTGGYCACATTGCT 5r TCCGTGCTTTATCCTGAGC	56	La: EF052256 Cg: EF052257	5a-B3 5b-B1 5c-B1F 5d-B1-dID
6	28865865	3865 - 4848	7qF5	6f CACTACCAGCCCTGYCTCTGC 6r TTCTGGGAGCAGTTGTARCAGC	60	La: EF052258	6-B1
7	14039817	277 - 877	11qB3	7f CAGCATCTTATCCGRGTGGAAGGA 7r CCAGCGTGATGATGGTRAGGAT	61	La: EF052259	7-PB1
9	6688666	2164 - 3274	6qE3	9f GCTGCGYCTGGACYTGGTT 9r TCTGAGTCAGTGTCCATACTTGATC	55	La: EF052260	9-ID4
10	7229519	434 - 851	2qH3	10f ATGCGGATCATGACKCGGATG 10r AGGGTCAGCTCMGGGTTGCA	56	La: EF052261	10-ID_B1
12	28475672	157143 - 1567709	qA5.2	12f GCTTTGTGGAGGAGCAGTGTAAGG 12r CCCAGGAAGATCATGCAGCAG	56	La: EF052262	12-ID4
13	4587088	17430 - 18261	XqA1.1	13f CAGTCTAGGCTCTTTGCTGATGA 13r TCTCTCGGATTAACATTAGWGTYTG	58	La: EF052263	13a-B1 13b-PB1 13c-ID4 13d-PB1 13e-B1 13f-ID4
14	27544615	7100 - 7402	4qD1	14f AAGTGGAARTTCACAGRCTGCTCAG 14r CAGGAAGRAGTCTTCACAAG	60	La: EF052264	14a-ID4 14b-ID4 14c-ID_B1
15	4587088	18236 - 19111	XqA1.1	15f CCARACWCTAATWTTAATCCGAGA 15r AATTGTAACTTTGTGAACAGATGCT	52	La: EF052265	15-ID2

La = Laonastes aenigmamus, Cg = Ctenodactylus gundi; italic lettering: diagnostic markers for La+Cg. Loci 3, 4, 8, 11, and 16 (26) were not amplifiable in La.

Detailed Molecular Dating Analysis

MULTIDIVTIME.Two molecular dating analyses were performed according to the Bayesian relaxed molecular clock approach (27, 28), using the MULTIDIVTIME package (29): a concatenated analysis (all genes evolving under the same model), and a partition analysis (all genes evolving under different models). First, the best fitting parameters for each of the six genes ADRA2B, GHR, IRBP, vWF, cyt b, 12S rRNA, and the concatenated data set were calculated via PAML (30), using the F84 model (because more complex models are not incorporated in the ESTBRANCHES program), five discrete gamma categories, and the same topology for all data sets. These parameters were then entered in the ESTBRANCHES program to calculate the branch lengths of the rooted ML tree (the dog was used as the outgroup) and their variance-covariance matrix under one partition (concatenated analysis) or each of the six partitions (partition analysis). Second, a priori knowledge was incorporated about the gamma distributions of (i) the root age, (ii) the substitution rate at the root, and (iii) the substitution rate autocorrelation along branches. These priors were specified as means and SD of the three distributions according to the MULTIDIVTIME guidelines. The posterior distributions of node times were approximated through MCMC runs by using the MULTIDIVTIME program. To verify that the program converged, all computations performed with MULTIDIVTIME were run twice, starting the MCMC runs from different initial values. In all cases, similar results were obtained for the two independent runs (we only report the results from one of the two runs).

r8s. The molecular dating estimates obtained with MULTIDIVTIME were cross-checked by an analysis conducted with r8s version 1.71 (31). This analysis was done by using the penalized likelihood method (PL) (32). PL is a semiparametric approach described in the manual of the program as a combination of "a parametric model having a different substitution rate on every branch with a nonparametric roughness penalty which costs the model more if rates change too quickly from branch to branch" (31). The relative contributions of these two parts of the PL model are determined by a smoothing parameter. The optimal smoothing parameter was obtained by cross-validation. A first rough estimation of the parameter was obtained by testing values ranging from 10⁰ to 10³ with the exponent rising from 0 to 3 in steps of 0.25. The neighborhood of this first estimation was then explored by using steps of 0.1. As recommended in the manual of the r8s program, computations were performed using the Log penalty function and the TN algorithm. Branch lengths used in the r8s analyses were ML estimates calculated with PAUP* using the concatenated data set and the best parameters estimated for the corresponding topology tree. Standard deviations on age estimates were calculated via nonparametric bootstrapping. Branch length estimates were computed for 100 bootstrap data sets using the topology and the model parameters of the best ML tree.

Calibration Points. For fossil calibrations we selected seven time constraints that have been used already in molecular dating studies (15, 33). Calibration constraints were chosen within and outside rodents. Corresponding paleontological references are indicated in Table S4. The a priori expected amount of time between tip and root was estimated to be 90 Myr with a standard deviation of 20 Myr. This prior was based on paleontological estimates of the divergence between Laurasiatheria (i.e., the dog: the outgroup of the molecular dating analyses) and Euarchontoglires (i.e., all other species of our data set). Paleontological studies have indicated that zhelestids (the probable ancestors of ungulates, and consequently of many Laurasiatheria members) are estimated to be 85 Myr old (34), and that zalambdalestids (the probable ancestor of Glires) are estimated to be 90 Myr old (35).

Table S4. Calibration points

Pairs of taxa	Paleontological dating	Age, Mya	Reference
RODENTIA
Erethizontidae+ Cavioidea - other caviomorphs	Radiation of Caviomorpha	28.5-37	36, 37
Glis -Dryomys	First appearance of Glirinae - Late Oligocene	28.5-50	38, 39
Aplodontia - Marmota	First appearance of Sciuridae - Late Eocene	>37	40
LAGOMORPHA
Leporidae - Ochotonidae	First appearance of Ochotonidae - Late Eocene Origin of Zalambdalestidae - Late Cretaceous	37-90	35, 40
Rodentia - Lagomorpha	First appearance of Lagomorphs and rodents in the Paleocene Origin of Zalambdalestidae - Late Cretaceous	55.4-90	35, 40
Primates
Homo- Macaca	Cercopithecoidea/ Hominoidea divergence	25-35	41, 42
Lemuridae- other primates	Basal primate radiation	63-90	43-45

The selected ages correspond to the minimum age estimation of the crown group under consideration.

Testing Alternative Topologies. Phylogenetic reconstructions including the dog (Canis familiaris) placed the tree shrew (Tupaia) as the most diverging taxa in our tree. However, this rooting was not supported with high support values (data not shown). To verify that the position of the root did not have a significant impact on the molecular dating results, we compared dating results obtained with two different positions of the root. The first topology, the ML tree, placed the tree shrew at the base of the tree (Fig. 3), the second topology placed the tree shrew as sister clade of Primates and Dermoptera [monophyly of Euarchonta (46)].

Detailed Molecular Dating Results

Age estimation of clades varied slightly with the two methods used: penalized likelihood and Bayesian relaxed clock (Table S5). Similarly, the position of the root did not have a significant impact on the dating results. The congruence between the results let us suggest that Laonastes is indeed an ancient lineage that split ~41.9-47.0 Mya from its closest sister clade, the Ctenodactylidae. The chronogram obtained using the Bayesian relaxed clock method with a separate model for different genes and the ML tree topology is indicated in Fig. S1.

Table S5. Divergence time estimations for three critical nodes: the split between Laonastes and Ctenodactylidae; the most recent common ancestor of Laonastes, Ctenodactylidae and Hystricognathi; and the most recent common ancestor of Rodentia

			Divergence dates (Mya)
Method	Data set	Topology	Laonastes + Ctenodactylidae	Laonastes + Ctenodactylidae + Hystricognathi	Rodentia
Bayesian	Separate	Best tree	44.26 (37.55-51.07)	61.30 (53.85-68.28)	72.08 (63.53-80.02)
Bayesian	Concatenate	Best tree	41.93 (34.85-48.99)	61.81 (54.33-68.47)	73.15 (64.53-79.89)
PL	Concatenate	Best tree	43.21 (39.17-47.25)	62.10 (57.63-66.57)	72.33 (68.59-76.07)
Bayesian	Separate	Alternative tree	44.79 (38.16-51.48)	61.89 (54.65-68.60)	72.81 (64.62-80.36)
Bayesian	Concatenate	Alternative tree	42.50 (35.37-49.58)	62.57 (55.15-69.13)	73.87 (65.44-80.43)
PL	Concatenate	Alternative tree	46.97 (43.32-50.62)	66.68 (62.86-70.50)	77.0 (73.79-80.21)

The 95% credibility intervals are indicated in parentheses. Bayesian = Bayesian relaxed clock method (27, 29). PL = penalized likelihood method (32). For the PL method, confidence intervals were computed as ± 1.96 times the SD of the bootstrapped samples. Separate: branch lengths and variance-covariance matrices were computed with different model parameters for each gene. Concatenated: branch lengths and variance-covariance matrices were computed with a single model of evolution for all genes. Best tree: computations are based on the best tree topology (Fig. 2). Alternative tree: computations are based on a topology that supports the tree shrew as the sister clade of Primates (46).

Fig. S1. Molecular time scale for the order Rodentia based on the MULTIDIVTIME analysis with different substitution models for each gene partition. Numbers at the nodes are the molecular date in million of years ago (Mya); values in parentheses are the 95% credibility intervals. Fossil constraints are indicated by black circles on the corresponding nodes; 1: [28.5-50 Mya] (38, 39), 2: [>37 Mya] (40), 3: [28.5-37 Mya] (36, 37), 4: [37-90 Mya] (35, 40), 5: [55.4-90 Mya] (35, 40), 6: [25-35 Mya] (41, 42), 7: [63-90 Mya] (43-45). The base of the ingroup root was constrained to 90 (± 20) Mya(34, 35). Ano., Anomaluromorpha; Cas., Castorimorpha; Cte., Ctenodactylidae; Dia., Diatomyidae; Gli. Gliridae; Hys., Hystricognathi; Myo., Myodonta; Out., Outgroups; Sci., Sciuroidea. CRE, Cretaceous; PAL, Paleocene; EOC, Eocene; OLI, Oligocene; MIO, Miocene; P, PlioPleistocene. Laonastes 25 and 410, BMNH 1998.25 and BMNH 1998.410.

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