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Edited by Eric N. Olson, University of Texas Southwestern Medical Center, Dallas, TX, and approved May 8, 2007 (received for review February 3, 2007)
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Article Information
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History:
- Published in issue August 28, 2007.
- Published first June 15, 2007.
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© 2007 by The National Academy of Sciences of the USA
Author Information
- Jing Liu *,
- Sherri D. Fraser *,
- Patrick W. Faloon † ,
- Evvi Lynn Rollins *,
- Johannes Vom Berg *,
- Olivera Starovic-Subota *,
- Angie L. Laliberte *,
- Jau-Nian Chen ‡ ,
- Fabrizio C. Serluca † , and
- Sarah J. Childs * , §
- *Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1;
- ‡Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, CA 90095; and
- †Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, MA 02139
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Edited by Eric N. Olson, University of Texas Southwestern Medical Center, Dallas, TX, and approved May 8, 2007 (received for review February 3, 2007)
Footnotes
- §To whom correspondence should be addressed. E-mail: schilds{at}ucalgary.ca
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Author contributions: J.L., S.D.F., P.W.F., J.V.B., A.L.L., and S.J.C. designed research; J.L., S.D.F., P.W.F., E.L.R., J.V.B., O.S.-S., A.L.L., and S.J.C. performed research; J.-N.C. and F.C.S. contributed new reagents/analytic tools; J.L., S.D.F., P.W.F., J.V.B., and S.J.C. analyzed data; and J.L., S.D.F., and S.J.C. wrote the paper.
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The authors declare no conflict of interest.
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This article is a PNAS Direct Submission.
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Data deposition: The sequences reported in this paper have been deposited in the GenBank database [accession nos. DQ656108 (βPix-A), DQ656109 (βPix-B), and DQ656110 (Pak2a)].
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This article contains supporting information online at www.pnas.org/cgi/content/full/0700825104/DC1.
- Abbreviations:
- CH,
- calponin homology;
- hpf,
- hours postfertilization;
- MO,
- morpholino antisense oligonucleotide;
- Pak,
- p21-activated kinase;
- Pix,
- Pak-interacting exchange factor.
- © 2007 by The National Academy of Sciences of the USA
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A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish
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