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Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial

Hannah V. Siddle, Alexandre Kreiss, Mark D. B. Eldridge, Erin Noonan, Candice J. Clarke, Stephen Pyecroft, Gregory M. Woods, and Katherine Belov
PNAS October 9, 2007 104 (41) 16221-16226; https://doi.org/10.1073/pnas.0704580104
Hannah V. Siddle
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Alexandre Kreiss
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Mark D. B. Eldridge
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Erin Noonan
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Candice J. Clarke
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Stephen Pyecroft
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Gregory M. Woods
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Katherine Belov
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  1. Edited by Daniel L. Hartl, Harvard University, Cambridge, MA, and approved August 23, 2007 (received for review May 16, 2007)

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Abstract

A fatal transmissible tumor spread between individuals by biting has emerged in the Tasmanian devil (Sarcophilus harrisii), a carnivorous marsupial. Here we provide genetic evidence establishing that the tumor is clonal and therefore foreign to host devils. Thus, the disease is highly unusual because it is not just a tumor but also a tissue graft, passed between individuals without invoking an immune response. The MHC plays a key role in immune responses to both tumors and grafts. The most common mechanism of immune evasion by tumors is down-regulation of classical cell surface MHC molecules. Here we show that this mode of immune escape does not occur. However, because the tumor is a graft, it should still be recognized and rejected by the host's immune system due to foreign cell surface antigens. Mixed lymphocyte responses showed a lack of alloreactivity between lymphocytes of different individuals in the affected population, indicating a paucity of MHC diversity. This result was verified by genotyping, providing a conclusive link between a loss of MHC diversity and spread of a disease through a wild population. This novel disease arose as a direct result of loss of genetic diversity and the aggressive behavior of the host species. The neoplastic clone continues to spread although the population, and, without active disease control by removal of affected animals and the isolation of disease-free animals, the Tasmanian devil faces extinction.

  • conservation genetics
  • Tasmanian devil
  • wildlife disease
  • immune evasion

Footnotes

  • ‡‡To whom correspondence should be addressed at:
    Faculty of Veterinary Science, RMC Gunn B19, University of Sydney, Sydney, NSW 2006, Australia.
    E-mail: kbelov{at}vetsci.usyd.edu.au
  • Author contributions: G.M.W. and K.B. designed research; H.V.S., A.K., E.N., and C.J.C. performed research; S.P. contributed new reagents/analytic tools; H.V.S., A.K., M.D.B.E., and K.B. analyzed data; and H.V.S. and K.B. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • Data deposition: The sequences reported in this paper have been deposited in the GenBank database [accession nos. EF591108 (3297T1), EF591109 (3297T2), EF591110 (3297T3), EF591111 (3297T4), EF591112 (3297T5), EU086720 (3297T6), EF591113 (3297DABT2), EF591114 (3297DABT3), EF59111 (3297DABT4), EF591116 (3297DABT1), EU094443 (Saha*1), EU094444 (Saha*2), EU094445 (Saha*3), EU094446 (Saha*4), EU094447 (Saha*5), EU094448 (Saha*6), EU094449 (Saha*7), EU094450 (Saha*8), EU094451 (Saha*9), EU094452 (Saha*10), EU094453 (Saha*11), EU094454 (Saha*12), EU094455 (Saha*13), EU094456 (Saha*14), EU094457 (Saha*15), EU094458 (Saha*16), EU094459 (Saha*17), EU094460 (Saha*18), EU094461 (Saha*19), EU094462 (Saha*20), EU094463 (Saha*21), EU094464 (Saha*22), EU094465 (Saha*23), EU094466 (Saha*24), EU094467 (Saha*25), and EU094468 (Saha*26)].

  • This article contains supporting information online at www.pnas.org/cgi/content/full/0704580104/DC1.

  • Abbreviations:
    DFTD,
    devil facial tumor disease;
    PBR,
    peptide binding region;
    CTVT,
    canine transmissible venereal tumor;
    SSCP,
    single-strand conformation polymorphism.
  • Freely available online through the PNAS open access option.

  • © 2007 by The National Academy of Sciences of the USA
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Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial
Hannah V. Siddle, Alexandre Kreiss, Mark D. B. Eldridge, Erin Noonan, Candice J. Clarke, Stephen Pyecroft, Gregory M. Woods, Katherine Belov
Proceedings of the National Academy of Sciences Oct 2007, 104 (41) 16221-16226; DOI: 10.1073/pnas.0704580104

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Transmission of a fatal clonal tumor by biting occurs due to depleted MHC diversity in a threatened carnivorous marsupial
Hannah V. Siddle, Alexandre Kreiss, Mark D. B. Eldridge, Erin Noonan, Candice J. Clarke, Stephen Pyecroft, Gregory M. Woods, Katherine Belov
Proceedings of the National Academy of Sciences Oct 2007, 104 (41) 16221-16226; DOI: 10.1073/pnas.0704580104
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