Table of Contents

Biological Sciences

• Anthropology

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    Savanna chimpanzees use tools to harvest the underground storage organs of plants

    • Cozzarelli Prize Winner
    • From the Cover

    R. Adriana Hernandez-Aguilar, Jim Moore, and Travis Rayne Pickering

    PNAS December 4, 2007 104 (49) 19210-19213; https://doi.org/10.1073/pnas.0707929104

    See companion article:

    • Savanna chimpanzees dig for food

      - Nov 28, 2007
    • In This Issue

      - Dec 04, 2007
  • Open Access

    Global climate change, war, and population decline in recent human history

    David D. Zhang, Peter Brecke, Harry F. Lee, Yuan-Qing He, and Jane Zhang

    PNAS December 4, 2007 104 (49) 19214-19219; https://doi.org/10.1073/pnas.0703073104
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    A new Late Miocene great ape from Kenya and its implications for the origins of African great apes and humans

    Yutaka Kunimatsu, Masato Nakatsukasa, Yoshihiro Sawada, Tetsuya Sakai, Masayuki Hyodo, Hironobu Hyodo, Tetsumaru Itaya, Hideo Nakaya, Haruo Saegusa, Arnaud Mazurier, Mototaka Saneyoshi, Hiroshi Tsujikawa, Ayumi Yamamoto, and Emma Mbua

    PNAS December 4, 2007 104 (49) 19220-19225; https://doi.org/10.1073/pnas.0706190104

    See companion article:

    • In This Issue

      - Dec 04, 2007
    • New apes fill the gap

      - Dec 05, 2007

• Biochemistry

  • Open Access

    A mathematical tool for exploring the dynamics of biological networks

    • Inaugural Article

    Paolo E. Barbano, Marina Spivak, Marc Flajolet, Angus C. Nairn, Paul Greengard, and Leslie Greengard

    PNAS December 4, 2007 104 (49) 19169-19174; https://doi.org/10.1073/pnas.0709955104
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    JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

    Yang Xiang, Ziqi Zhu, Gang Han, Xiaolei Ye, Bo Xu, Zhouchun Peng, Yuanjun Ma, Yi Yu, Hanqing Lin, Adele Pin Chen, and Charlie Degui Chen

    PNAS December 4, 2007 104 (49) 19226-19231; https://doi.org/10.1073/pnas.0700735104
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    Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Aβ protofibrils

    Gernot Habicht, Christian Haupt, Ralf P. Friedrich, Peter Hortschansky, Carsten Sachse, Jessica Meinhardt, Karin Wieligmann, Gerald P. Gellermann, Michael Brodhun, Jürgen Götz, Karl-Jürgen Halbhuber, Christoph Röcken, Uwe Horn, and Marcus Fändrich

    PNAS December 4, 2007 104 (49) 19232-19237; https://doi.org/10.1073/pnas.0703793104
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    Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation

    Kristina W. Thiel and Graham Carpenter

    PNAS December 4, 2007 104 (49) 19238-19243; https://doi.org/10.1073/pnas.0703854104
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    Antiinflammatory glucocorticoid receptor ligand with reduced side effects exhibits an altered protein–protein interaction profile

    Jeffrey N. Miner, Bob Ardecky, Khalid Benbatoul, Kimberly Griffiths, Christopher J. Larson, Dale E. Mais, Keith Marschke, Jon Rosen, Eric Vajda, Lin Zhi, and Andres Negro-Vilar

    PNAS December 4, 2007 104 (49) 19244-19249; https://doi.org/10.1073/pnas.0705517104
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    Mitochondrial origin-binding protein UMSBP mediates DNA replication and segregation in trypanosomes

    Neta Milman, Shawn A. Motyka, Paul T. Englund, Derrick Robinson, and Joseph Shlomai

    PNAS December 4, 2007 104 (49) 19250-19255; https://doi.org/10.1073/pnas.0706858104
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    Protein–protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein

    Stéphane Betzi, Audrey Restouin, Sandrine Opi, Stefan T. Arold, Isabelle Parrot, Françoise Guerlesquin, Xavier Morelli, and Yves Collette

    PNAS December 4, 2007 104 (49) 19256-19261; https://doi.org/10.1073/pnas.0707130104
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    Laforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo

    Vincent S. Tagliabracci, Julie Turnbull, Wei Wang, Jean-Marie Girard, Xiaochu Zhao, Alexander V. Skurat, Antonio V. Delgado-Escueta, Berge A. Minassian, Anna A. DePaoli-Roach, and Peter J. Roach

    PNAS December 4, 2007 104 (49) 19262-19266; https://doi.org/10.1073/pnas.0707952104
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    A novel polydnavirus protein inhibits the insect prophenoloxidase activation pathway

    Markus H. Beck and Michael R. Strand

    PNAS December 4, 2007 104 (49) 19267-19272; https://doi.org/10.1073/pnas.0708056104
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    The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model

    So R. Kim, Young P. Jang, Steffen Jockusch, Nathan E. Fishkin, Nicholas J. Turro, and Janet R. Sparrow

    PNAS December 4, 2007 104 (49) 19273-19278; https://doi.org/10.1073/pnas.0708714104
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    Structure of the Nitrosomonas europaea Rh protein

    Xin Li, Sanjay Jayachandran, Hiep-Hoa T. Nguyen, and Michael K. Chan

    PNAS December 4, 2007 104 (49) 19279-19284; https://doi.org/10.1073/pnas.0709710104
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    Regulation of hypothalamic malonyl-CoA by central glucose and leptin

    Michael J. Wolfgang, Seung Hun Cha, Aniket Sidhaye, Shigeru Chohnan, Gary Cline, Gerald I. Shulman, and M. Daniel Lane

    PNAS December 4, 2007 104 (49) 19285-19290; https://doi.org/10.1073/pnas.0709778104
  • Open Access

    A biochemical approach to identifying microRNA targets

    Fedor V. Karginov, Cecilia Conaco, Zhenyu Xuan, Bryan H. Schmidt, Joel S. Parker, Gail Mandel, and Gregory J. Hannon

    PNAS December 4, 2007 104 (49) 19291-19296; https://doi.org/10.1073/pnas.0709971104

• Biophysics

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    Construction of effective free energy landscape from single-molecule time series

    Akinori Baba and Tamiki Komatsuzaki

    PNAS December 4, 2007 104 (49) 19297-19302; https://doi.org/10.1073/pnas.0704167104
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    The 1.3-Å resolution structure of Nitrosomonas europaea Rh50 and mechanistic implications for NH₃ transport by Rhesus family proteins

    Domenico Lupo, Xiao-Dan Li, Anne Durand, Takashi Tomizaki, Baya Cherif-Zahar, Giorgio Matassi, Mike Merrick, and Fritz K. Winkler

    PNAS December 4, 2007 104 (49) 19303-19308; https://doi.org/10.1073/pnas.0706563104
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    Disulfide bond influence on protein structural dynamics probed with 2D-IR vibrational echo spectroscopy

    Haruto Ishikawa, Seongheun Kim, Kyungwon Kwak, Keisuke Wakasugi, and Michael D. Fayer

    PNAS December 4, 2007 104 (49) 19309-19314; https://doi.org/10.1073/pnas.0709760104
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    Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins

    Manjuli R. Sharma, Daniel N. Wilson, Partha P. Datta, Chandana Barat, Frank Schluenzen, Paola Fucini, and Rajendra K. Agrawal

    PNAS December 4, 2007 104 (49) 19315-19320; https://doi.org/10.1073/pnas.0709856104
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    Mechanoenzymes under superstall and large assisting loads reveal structural features

    Denis Tsygankov and Michael E. Fisher

    PNAS December 4, 2007 104 (49) 19321-19326; https://doi.org/10.1073/pnas.0709911104

• Cell Biology

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    Subnetwork analysis reveals dynamic features of complex (bio)chemical networks

    Carsten Conradi, Dietrich Flockerzi, Jörg Raisch, and Jörg Stelling

    PNAS December 4, 2007 104 (49) 19175-19180; https://doi.org/10.1073/pnas.0705731104
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    Matrix metalloproteinase 7 controls pancreatic acinar cell transdifferentiation by activating the Notch signaling pathway

    Eric T. Sawey, Johnny A. Johnson, and Howard C. Crawford

    PNAS December 4, 2007 104 (49) 19327-19332; https://doi.org/10.1073/pnas.0705953104
  • Open Access

    Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP

    Tadao Shibasaki, Harumi Takahashi, Takashi Miki, Yasuhiro Sunaga, Kimio Matsumura, Mami Yamanaka, Changliang Zhang, Atsuko Tamamoto, Takaya Satoh, Jun-ichi Miyazaki, and Susumu Seino

    PNAS December 4, 2007 104 (49) 19333-19338; https://doi.org/10.1073/pnas.0707054104
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    Structural differentiation of skeletal muscle fibers in the absence of innervation in humans

    Simona Boncompagni, Helmut Kern, Katia Rossini, Christian Hofer, Winfried Mayr, Ugo Carraro, and Feliciano Protasi

    PNAS December 4, 2007 104 (49) 19339-19344; https://doi.org/10.1073/pnas.0709061104
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    Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

    Ralph J. DeBerardinis, Anthony Mancuso, Evgueni Daikhin, Ilana Nissim, Marc Yudkoff, Suzanne Wehrli, and Craig B. Thompson

    PNAS December 4, 2007 104 (49) 19345-19350; https://doi.org/10.1073/pnas.0709747104

• Developmental Biology

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    DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status

    Kevin D. Sinclair, Cinzia Allegrucci, Ravinder Singh, David S. Gardner, Sonia Sebastian, Jayson Bispham, Alexandra Thurston, John F. Huntley, William D. Rees, Christopher A. Maloney, Richard G. Lea, Jim Craigon, Tom G. McEvoy, and Lorraine E. Young

    PNAS December 4, 2007 104 (49) 19351-19356; https://doi.org/10.1073/pnas.0707258104
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    Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

    • From the Cover

    Christine A. White, Jian-Guo Zhang, Lois A. Salamonsen, Manuel Baca, W. Douglas Fairlie, Donald Metcalf, Nicos A. Nicola, Lorraine Robb, and Evdokia Dimitriadis

    PNAS December 4, 2007 104 (49) 19357-19362; https://doi.org/10.1073/pnas.0710110104

• Evolution

  • Open Access

    Using plastid genome-scale data to resolve enigmatic relationships among basal angiosperms

    Michael J. Moore, Charles D. Bell, Pamela S. Soltis, and Douglas E. Soltis

    PNAS December 4, 2007 104 (49) 19363-19368; https://doi.org/10.1073/pnas.0708072104
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    Analysis of 81 genes from 64 plastid genomes resolves relationships in angiosperms and identifies genome-scale evolutionary patterns

    Robert K. Jansen, Zhengqiu Cai, Linda A. Raubeson, Henry Daniell, Claude W. dePamphilis, James Leebens-Mack, Kai F. Müller, Mary Guisinger-Bellian, Rosemarie C. Haberle, Anne K. Hansen, Timothy W. Chumley, Seung-Bum Lee, Rhiannon Peery, Joel R. McNeal, Jennifer V. Kuehl, and Jeffrey L. Boore

    PNAS December 4, 2007 104 (49) 19369-19374; https://doi.org/10.1073/pnas.0709121104
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    Long-term evolution of transposable elements

    Arnaud Le Rouzic, Thibaud S. Boutin, and Pierre Capy

    PNAS December 4, 2007 104 (49) 19375-19380; https://doi.org/10.1073/pnas.0705238104
  • Open Access

    The signal environment is more important than diet or chemical specialization in the evolution of warning coloration

    • From the Cover

    Kathleen L. Prudic, Jeffrey C. Oliver, and Felix A. H. Sperling

    PNAS December 4, 2007 104 (49) 19381-19386; https://doi.org/10.1073/pnas.0705478104
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    Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds

    Hyun Seok Kim and Justin C. Fay

    PNAS December 4, 2007 104 (49) 19387-19391; https://doi.org/10.1073/pnas.0708194104
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    Parallel genomic evolution and metabolic interdependence in an ancient symbiosis

    John P. McCutcheon and Nancy A. Moran

    PNAS December 4, 2007 104 (49) 19392-19397; https://doi.org/10.1073/pnas.0708855104

    See companion article:

    • In This Issue

      - Dec 04, 2007
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    Extensive simple sequence repeat genotyping of potato landraces supports a major reevaluation of their gene pool structure and classification

    David M. Spooner, Jorge Núñez, Guillermo Trujillo, María del Rosario Herrera, Frank Guzmán, and Marc Ghislain

    PNAS December 4, 2007 104 (49) 19398-19403; https://doi.org/10.1073/pnas.0709796104
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    Evolutionary plasticity of developmental gene regulatory network architecture

    Veronica F. Hinman and Eric H. Davidson

    PNAS December 4, 2007 104 (49) 19404-19409; https://doi.org/10.1073/pnas.0709994104

• Genetics

  • Open Access

    A forest-based approach to identifying gene and gene–gene interactions

    Xiang Chen, Ching-Ti Liu, Meizhuo Zhang, and Heping Zhang

    PNAS December 4, 2007 104 (49) 19199-19203; https://doi.org/10.1073/pnas.0709868104
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    Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination

    Morten Ejby, Michael A. Sørensen, and Steen Pedersen

    PNAS December 4, 2007 104 (49) 19410-19415; https://doi.org/10.1073/pnas.0706558104
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    Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes

    Dag H. Yasui, Sailaja Peddada, Mark C. Bieda, Roxanne O. Vallero, Amber Hogart, Raman P. Nagarajan, Karen N. Thatcher, Peggy J. Farnham, and Janine M. LaSalle

    PNAS December 4, 2007 104 (49) 19416-19421; https://doi.org/10.1073/pnas.0707442104
  • Open Access

    A knockin mouse model of the Bardet–Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity

    Roger E. Davis, Ruth E. Swiderski, Kamal Rahmouni, Darryl Y. Nishimura, Robert F. Mullins, Khristofor Agassandian, Alisdair R. Philp, Charles C. Searby, Michael P. Andrews, Stewart Thompson, Christopher J. Berry, Daniel R. Thedens, Baoli Yang, Robert M. Weiss, Martin D. Cassell, Edwin M. Stone, and Val C. Sheffield

    PNAS December 4, 2007 104 (49) 19422-19427; https://doi.org/10.1073/pnas.0708571104
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    Distinguishing protein-coding and noncoding genes in the human genome

    • From the Cover

    Michele Clamp, Ben Fry, Mike Kamal, Xiaohui Xie, James Cuff, Michael F. Lin, Manolis Kellis, Kerstin Lindblad-Toh, and Eric S. Lander

    PNAS December 4, 2007 104 (49) 19428-19433; https://doi.org/10.1073/pnas.0709013104

    See companion article:

    • In This Issue

      - Dec 04, 2007

• Immunology

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    Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response

    Iván Mulero, M. Pilar Sepulcre, José Meseguer, Alfonsa García-Ayala, and Victoriano Mulero

    PNAS December 4, 2007 104 (49) 19434-19439; https://doi.org/10.1073/pnas.0704535104
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    Chronic stimulation of Nod2 mediates tolerance to bacterial products

    Matija Hedl, Jing Li, Judy H. Cho, and Clara Abraham

    PNAS December 4, 2007 104 (49) 19440-19445; https://doi.org/10.1073/pnas.0706097104
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    CD4⁺CD25⁺Foxp3⁺ regulatory T cells induce alternative activation of human monocytes/macrophages

    Machteld M. Tiemessen, Ann L. Jagger, Hayley G. Evans, Martijn J. C. van Herwijnen, Susan John, and Leonie S. Taams

    PNAS December 4, 2007 104 (49) 19446-19451; https://doi.org/10.1073/pnas.0706832104
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    Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function

    Kausik Chattopadhyay, Udupi A. Ramagopal, Arunika Mukhopadhaya, Vladimir N. Malashkevich, Teresa P. DiLorenzo, Michael Brenowitz, Stanley G. Nathenson, and Steven C. Almo

    PNAS December 4, 2007 104 (49) 19452-19457; https://doi.org/10.1073/pnas.0709264104
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    B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

    Xingxing Zang, R. Houston Thompson, Hikmat A. Al-Ahmadie, Angel M. Serio, Victor E. Reuter, James A. Eastham, Peter T. Scardino, Padmanee Sharma, and James P. Allison

    PNAS December 4, 2007 104 (49) 19458-19463; https://doi.org/10.1073/pnas.0709802104

• Medical Sciences

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    Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1

    Lot de Witte, Michael Bobardt, Udayan Chatterji, Gisèle Degeest, Guido David, Teunis B. H. Geijtenbeek, and Philippe Gallay

    PNAS December 4, 2007 104 (49) 19464-19469; https://doi.org/10.1073/pnas.0703747104
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    Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics

    Suresh K. Rayala, Emil Martin, Iraida G. Sharina, Poonam R. Molli, Xiaoping Wang, Raymond Jacobson, Ferid Murad, and Rakesh Kumar

    PNAS December 4, 2007 104 (49) 19470-19475; https://doi.org/10.1073/pnas.0705149104
  • Open Access

    Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity

    Cyril Couturier, Chamsy Sarkis, Karin Séron, Sandrine Belouzard, Patty Chen, Aude Lenain, Laetitia Corset, Julie Dam, Virginie Vauthier, Anne Dubart, Jacques Mallet, Philippe Froguel, Yves Rouillé, and Ralf Jockers

    PNAS December 4, 2007 104 (49) 19476-19481; https://doi.org/10.1073/pnas.0706671104
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    HDAC inhibitor PCI-24781 decreases RAD51 expression and inhibits homologous recombination

    Shanthi Adimoolam, Mint Sirisawad, Jun Chen, Patti Thiemann, James M. Ford, and Joseph J. Buggy

    PNAS December 4, 2007 104 (49) 19482-19487; https://doi.org/10.1073/pnas.0707828104
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    Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition

    Mikhail A. Nikiforov, MaryBeth Riblett, Wen-Hua Tang, Vladimir Gratchouck, Dazhong Zhuang, Yolanda Fernandez, Monique Verhaegen, Sooryanarayana Varambally, Arul M. Chinnaiyan, Andrzej J. Jakubowiak, and Maria S. Soengas

    PNAS December 4, 2007 104 (49) 19488-19493; https://doi.org/10.1073/pnas.0708380104
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    In vivo multiphoton microscopy of NADH and FAD redox states, fluorescence lifetimes, and cellular morphology in precancerous epithelia

    Melissa C. Skala, Kristin M. Riching, Annette Gendron-Fitzpatrick, Jens Eickhoff, Kevin W. Eliceiri, John G. White, and Nirmala Ramanujam

    PNAS December 4, 2007 104 (49) 19494-19499; https://doi.org/10.1073/pnas.0708425104
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    NIX is required for programmed mitochondrial clearance during reticulocyte maturation

    Rachel L. Schweers, Ji Zhang, Mindy S. Randall, Melanie R. Loyd, Weimin Li, Frank C. Dorsey, Mondira Kundu, Joseph T. Opferman, John L. Cleveland, Jeffery L. Miller, and Paul A. Ney

    PNAS December 4, 2007 104 (49) 19500-19505; https://doi.org/10.1073/pnas.0708818104
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    ID genes mediate tumor reinitiation during breast cancer lung metastasis

    Gaorav P. Gupta, Jonathan Perk, Swarnali Acharyya, Paola de Candia, Vivek Mittal, Katia Todorova-Manova, William L. Gerald, Edi Brogi, Robert Benezra, and Joan Massagué

    PNAS December 4, 2007 104 (49) 19506-19511; https://doi.org/10.1073/pnas.0709185104
  • Open Access

    Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

    Mai Nguyen, Richard C. Marcellus, Anne Roulston, Mark Watson, Lucile Serfass, S. R. Murthy Madiraju, Daniel Goulet, Jean Viallet, Laurent Bélec, Xavier Billot, Stephane Acoca, Enrico Purisima, Adrian Wiegmans, Leonie Cluse, Ricky W. Johnstone, Pierre Beauparlant, and Gordon C. Shore

    PNAS December 4, 2007 104 (49) 19512-19517; https://doi.org/10.1073/pnas.0709443104

• Microbiology

  • Open Access

    Cytoskeletal “jellyfish” structure of Mycoplasma mobile

    Daisuke Nakane and Makoto Miyata

    PNAS December 4, 2007 104 (49) 19518-19523; https://doi.org/10.1073/pnas.0704280104
  • Open Access

    Rapid magnetosome formation shown by real-time x-ray magnetic circular dichroism

    Sarah Staniland, Bruce Ward, Andrew Harrison, Gerrit van der Laan, and Neil Telling

    PNAS December 4, 2007 104 (49) 19524-19528; https://doi.org/10.1073/pnas.0704879104
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    Substrate binding by a bacterial ABC transporter involved in polysaccharide export

    Leslie Cuthbertson, Matthew S. Kimber, and Chris Whitfield

    PNAS December 4, 2007 104 (49) 19529-19534; https://doi.org/10.1073/pnas.0705709104
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    Crystal structure of measles virus hemagglutinin provides insight into effective vaccines

    Takao Hashiguchi, Mizuho Kajikawa, Nobuo Maita, Makoto Takeda, Kimiko Kuroki, Kaori Sasaki, Daisuke Kohda, Yusuke Yanagi, and Katsumi Maenaka

    PNAS December 4, 2007 104 (49) 19535-19540; https://doi.org/10.1073/pnas.0707830104

    See companion article:

    • Structure of the measles virus H glycoprotein sheds light on an efficient vaccine

      - Dec 17, 2007
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    Human papillomaviruses activate caspases upon epithelial differentiation to induce viral genome amplification

    Cary A. Moody, Amelie Fradet-Turcotte, Jacques Archambault, and Laimonis A. Laimins

    PNAS December 4, 2007 104 (49) 19541-19546; https://doi.org/10.1073/pnas.0707947104
  • Open Access

    The P2 capsid protein of the nonenveloped rice dwarf phytoreovirus induces membrane fusion in insect host cells

    Feng Zhou, Yingying Pu, Taiyun Wei, Huijun Liu, Wulan Deng, Chunhong Wei, Biao Ding, Toshihiro Omura, and Yi Li

    PNAS December 4, 2007 104 (49) 19547-19552; https://doi.org/10.1073/pnas.0708946104

• Neuroscience

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    The blinking spotlight of attention

    Rufin VanRullen, Thomas Carlson, and Patrick Cavanagh

    PNAS December 4, 2007 104 (49) 19204-19209; https://doi.org/10.1073/pnas.0707316104
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    Regulation of spine morphology and spine density by NMDA receptor signaling in vivo

    Sila K. Ultanir, Ji-Eun Kim, Benjamin J. Hall, Thomas Deerinck, Mark Ellisman, and Anirvan Ghosh

    PNAS December 4, 2007 104 (49) 19553-19558; https://doi.org/10.1073/pnas.0704031104
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    Modulation of metabolic brain networks after subthalamic gene therapy for Parkinson's disease

    Andrew Feigin, Michael G. Kaplitt, Chengke Tang, Tanya Lin, Paul Mattis, Vijay Dhawan, Matthew J. During, and David Eidelberg

    PNAS December 4, 2007 104 (49) 19559-19564; https://doi.org/10.1073/pnas.0706006104
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    Redundant and unique roles of retinol dehydrogenases in the mouse retina

    Akiko Maeda, Tadao Maeda, Wenyu Sun, Houbin Zhang, Wolfgang Baehr, and Krzysztof Palczewski

    PNAS December 4, 2007 104 (49) 19565-19570; https://doi.org/10.1073/pnas.0707477104
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    A structural basis for enhancement of long-term associative memory in single dendritic spines regulated by PKC

    Jarin Hongpaisan and Daniel L. Alkon

    PNAS December 4, 2007 104 (49) 19571-19576; https://doi.org/10.1073/pnas.0709311104
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    Specific subgroups of Fru^M neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster

    Yick-Bun Chan and Edward A. Kravitz

    PNAS December 4, 2007 104 (49) 19577-19582; https://doi.org/10.1073/pnas.0709803104
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    A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse

    Christian Grimm, Math P. Cuajungco, Alexander F. J. van Aken, Michael Schnee, Simone Jörs, Corné J. Kros, Anthony J. Ricci, and Stefan Heller

    PNAS December 4, 2007 104 (49) 19583-19588; https://doi.org/10.1073/pnas.0709846104

• Pharmacology

  • Open Access

    Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

    Xiu Jun Wang, John D. Hayes, Colin J. Henderson, and C. Roland Wolf

    PNAS December 4, 2007 104 (49) 19589-19594; https://doi.org/10.1073/pnas.0709483104
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    Acute-phase protein α-1-acid glycoprotein mediates neutrophil migration failure in sepsis by a nitric oxide-dependent mechanism

    F. L. A. C. Mestriner, F. Spiller, H. J. Laure, F. O. Souto, B. M. Tavares-Murta, J. C. Rosa, A. Basile-Filho, S. H. Ferreira, L. J. Greene, and F. Q. Cunha

    PNAS December 4, 2007 104 (49) 19595-19600; https://doi.org/10.1073/pnas.0709681104

• Physiology

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    β cell-specific deficiency of the stimulatory G protein α-subunit G_sα leads to reduced β cell mass and insulin-deficient diabetes

    Tao Xie, Min Chen, Qing-Hong Zhang, Zheng Ma, and Lee S. Weinstein

    PNAS December 4, 2007 104 (49) 19601-19606; https://doi.org/10.1073/pnas.0704796104
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    Yeast gain-of-function mutations reveal structure–function relationships conserved among different subfamilies of transient receptor potential channels

    Zhenwei Su, Xinliang Zhou, W. John Haynes, Stephen H. Loukin, Andriy Anishkin, Yoshiro Saimi, and Ching Kung

    PNAS December 4, 2007 104 (49) 19607-19612; https://doi.org/10.1073/pnas.0708584104

• Plant Biology

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    CERK1, a LysM receptor kinase, is essential for chitin elicitor signaling in Arabidopsis

    Ayako Miya, Premkumar Albert, Tomonori Shinya, Yoshitake Desaki, Kazuya Ichimura, Ken Shirasu, Yoshihiro Narusaka, Naoto Kawakami, Hanae Kaku, and Naoto Shibuya

    PNAS December 4, 2007 104 (49) 19613-19618; https://doi.org/10.1073/pnas.0705147104
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    Phloem loading in Verbascum phoeniceum L. depends on the synthesis of raffinose-family oligosaccharides

    Ashlee McCaskill and Robert Turgeon

    PNAS December 4, 2007 104 (49) 19619-19624; https://doi.org/10.1073/pnas.0707368104
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    AUREOCHROME, a photoreceptor required for photomorphogenesis in stramenopiles

    Fumio Takahashi, Daisuke Yamagata, Mié Ishikawa, Yosuke Fukamatsu, Yasunobu Ogura, Masahiro Kasahara, Tomohiro Kiyosue, Munehiro Kikuyama, Masamitsu Wada, and Hironao Kataoka

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    Delayed leaf senescence induces extreme drought tolerance in a flowering plant

    Rosa M. Rivero, Mikiko Kojima, Amira Gepstein, Hitoshi Sakakibara, Ron Mittler, Shimon Gepstein, and Eduardo Blumwald

    PNAS December 4, 2007 104 (49) 19631-19636; https://doi.org/10.1073/pnas.0709453104
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    Vitamin B1 biosynthesis in plants requires the essential iron–sulfur cluster protein, THIC

    Maja Raschke, Lukas Bürkle, Nadine Müller, Adriano Nunes-Nesi, Alisdair R. Fernie, Duilio Arigoni, Nikolaus Amrhein, and Teresa B. Fitzpatrick

    PNAS December 4, 2007 104 (49) 19637-19642; https://doi.org/10.1073/pnas.0709597104

• Psychology

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    Task-specific change of unconscious neural priming in the cerebral language network

    Kimihiro Nakamura, Stanislas Dehaene, Antoinette Jobert, Denis Le Bihan, and Sid Kouider

    PNAS December 4, 2007 104 (49) 19643-19648; https://doi.org/10.1073/pnas.0704487104
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    Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation

    • From the Cover

    P. Shaw, K. Eckstrand, W. Sharp, J. Blumenthal, J. P. Lerch, D. Greenstein, L. Clasen, A. Evans, J. Giedd, and J. L. Rapoport

    PNAS December 4, 2007 104 (49) 19649-19654; https://doi.org/10.1073/pnas.0707741104

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    • In This Issue

      - Dec 04, 2007
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      - Dec 06, 2007