Table of Contents

Biological Sciences

• Anthropology

  • Open Access

    Recent acceleration of human adaptive evolution

    John Hawks, Eric T. Wang, Gregory M. Cochran, Henry C. Harpending, and Robert K. Moyzis

    PNAS December 26, 2007 104 (52) 20753-20758; https://doi.org/10.1073/pnas.0707650104

• Biochemistry

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    CLC Cl⁻/H⁺ transporters constrained by covalent cross-linking

    • Inaugural Article

    Wang Nguitragool and Christopher Miller

    PNAS December 26, 2007 104 (52) 20659-20665; https://doi.org/10.1073/pnas.0708639104
  • Open Access

    Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

    Bin Wang and Stephen J. Elledge

    PNAS December 26, 2007 104 (52) 20759-20763; https://doi.org/10.1073/pnas.0710061104
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    Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

    Oriol Gallego, F. Xavier Ruiz, Albert Ardèvol, Marta Domínguez, Rosana Alvarez, Angel R. de Lera, Carme Rovira, Jaume Farrés, Ignacio Fita, and Xavier Parés

    PNAS December 26, 2007 104 (52) 20764-20769; https://doi.org/10.1073/pnas.0705659105
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    Thiamine biosynthesis in algae is regulated by riboswitches

    Martin T. Croft, Michael Moulin, Michael E. Webb, and Alison G. Smith

    PNAS December 26, 2007 104 (52) 20770-20775; https://doi.org/10.1073/pnas.0705786105
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    The product of uncI gene in F₁F_o-ATP synthase operon plays a chaperone-like role to assist c-ring assembly

    Toshiharu Suzuki, Yoko Ozaki, Nobuhito Sone, Boris A. Feniouk, and Masasuke Yoshida

    PNAS December 26, 2007 104 (52) 20776-20781; https://doi.org/10.1073/pnas.0708075105
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    Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions

    Ian C. Dews and Kevin R. MacKenzie

    PNAS December 26, 2007 104 (52) 20782-20787; https://doi.org/10.1073/pnas.0708909105
  • Open Access

    Folding trajectories of human dihydrofolate reductase inside the GroEL–GroES chaperonin cavity and free in solution

    Reto Horst, Wayne A. Fenton, S. Walter Englander, Kurt Wüthrich, and Arthur L. Horwich

    PNAS December 26, 2007 104 (52) 20788-20792; https://doi.org/10.1073/pnas.0710042105
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    SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells

    Jung Hwa Kim, Ji Min Lee, Hye Jin Nam, Hee June Choi, Jung Woo Yang, Jason S. Lee, Mi Hyang Kim, Su-Il Kim, Chin Ha Chung, Keun Il Kim, and Sung Hee Baek

    PNAS December 26, 2007 104 (52) 20793-20798; https://doi.org/10.1073/pnas.0710343105

• Biophysics

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    Dynamical magnetostructural properties of Anabaena ferredoxin

    Eduard Schreiner, Nisanth N. Nair, Rodolphe Pollet, Volker Staemmler, and Dominik Marx

    PNAS December 26, 2007 104 (52) 20725-20730; https://doi.org/10.1073/pnas.0706740104
  • Open Access

    Chemical mimicry of viral capsid self-assembly

    Arthur J. Olson, Yunfeng H. E. Hu, and Ehud Keinan

    PNAS December 26, 2007 104 (52) 20731-20736; https://doi.org/10.1073/pnas.0709489104
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    Axis-dependent anisotropy in protein unfolding from integrated nonequilibrium single-molecule experiments, analysis, and simulation

    Rene A. Nome, Jason Ming Zhao, Wouter D. Hoff, and Norbert F. Scherer

    PNAS December 26, 2007 104 (52) 20799-20804; https://doi.org/10.1073/pnas.0701281105
  • Open Access

    Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes

    Henry D. Herce and Angel E. Garcia

    PNAS December 26, 2007 104 (52) 20805-20810; https://doi.org/10.1073/pnas.0706574105
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    Nanosecond electron tunneling between the hemes in cytochrome bo₃

    Audrius Jasaitis, Mikael P. Johansson, Mårten Wikström, Marten H. Vos, and Michael I. Verkhovsky

    PNAS December 26, 2007 104 (52) 20811-20814; https://doi.org/10.1073/pnas.0709876105

• Cell Biology

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    Combinatorics of feedback in cellular uptake and metabolism of small molecules

    Sandeep Krishna, Szabolcs Semsey, and Kim Sneppen

    PNAS December 26, 2007 104 (52) 20815-20819; https://doi.org/10.1073/pnas.0706231105
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    Differential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues

    Carrie E. Johnson, Yolanda Y. Huang, Amanda B. Parrish, Michelle I. Smith, Allyson E. Vaughn, Qian Zhang, Kevin M. Wright, Terry Van Dyke, Robert J. Wechsler-Reya, Sally Kornbluth, and Mohanish Deshmukh

    PNAS December 26, 2007 104 (52) 20820-20825; https://doi.org/10.1073/pnas.0709101105
  • Open Access

    Regulation of p53 tetramerization and nuclear export by ARC

    Roger S.-Y. Foo, Young-Jae Nam, Marc Jason Ostreicher, Mark D. Metzl, Russell S. Whelan, Chang-Fu Peng, Anthony W. Ashton, Weimin Fu, Kartik Mani, Suet-Feung Chin, Elena Provenzano, Ian Ellis, Nichola Figg, Sarah Pinder, Martin R. Bennett, Carlos Caldas, and Richard N. Kitsis

    PNAS December 26, 2007 104 (52) 20826-20831; https://doi.org/10.1073/pnas.0710017104
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    Three-dimensional structure of cytoplasmic dynein bound to microtubules

    Naoko Mizuno, Akihiro Narita, Takahide Kon, Kazuo Sutoh, and Masahide Kikkawa

    PNAS December 26, 2007 104 (52) 20832-20837; https://doi.org/10.1073/pnas.0710406105

• Chemistry

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    A synthetic host-guest system achieves avidin-biotin affinity by overcoming enthalpy–entropy compensation

    Mikhail V. Rekharsky, Tadashi Mori, Cheng Yang, Young Ho Ko, N. Selvapalam, Hyunuk Kim, David Sobransingh, Angel E. Kaifer, Simin Liu, Lyle Isaacs, Wei Chen, Sarvin Moghaddam, Michael K. Gilson, Kimoon Kim, and Yoshihisa Inoue

    PNAS December 26, 2007 104 (52) 20737-20742; https://doi.org/10.1073/pnas.0706407105
  • Open Access

    A potent cytotoxic photoactivated platinum complex

    Fiona S. Mackay, Julie A. Woods, Pavla Heringová, Jana Kašpárková, Ana M. Pizarro, Stephen A. Moggach, Simon Parsons, Viktor Brabec, and Peter J. Sadler

    PNAS December 26, 2007 104 (52) 20743-20748; https://doi.org/10.1073/pnas.0707742105
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    An extended dynamical hydration shell around proteins

    Simon Ebbinghaus, Seung Joong Kim, Matthias Heyden, Xin Yu, Udo Heugen, Martin Gruebele, David M. Leitner, and Martina Havenith

    PNAS December 26, 2007 104 (52) 20749-20752; https://doi.org/10.1073/pnas.0709207104

• Developmental Biology

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    Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells

    Charles Durand, Catherine Robin, Karine Bollerot, Margaret H. Baron, Katrin Ottersbach, and Elaine Dzierzak

    PNAS December 26, 2007 104 (52) 20838-20843; https://doi.org/10.1073/pnas.0706923105
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    An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

    Ning Liu, Andrew H. Williams, Yuri Kim, John McAnally, Svetlana Bezprozvannaya, Lillian B. Sutherland, James A. Richardson, Rhonda Bassel-Duby, and Eric N. Olson

    PNAS December 26, 2007 104 (52) 20844-20849; https://doi.org/10.1073/pnas.0710558105
  • Open Access

    Site-directed, virus-free, and inducible RNAi in embryonic stem cells

    Jianlong Wang, Thorold W. Theunissen, and Stuart H. Orkin

    PNAS December 26, 2007 104 (52) 20850-20855; https://doi.org/10.1073/pnas.0710565105

• Ecology

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    Incorporating plant functional diversity effects in ecosystem service assessments

    • Cozzarelli Prize Winner

    Sandra Díaz, Sandra Lavorel, Francesco de Bello, Fabien Quétier, Karl Grigulis, and T. Matthew Robson

    PNAS December 26, 2007 104 (52) 20684-20689; https://doi.org/10.1073/pnas.0704716104
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    Trophic ecology of invasive Argentine ants in their native and introduced ranges

    Chadwick V. Tillberg, David A. Holway, Edward G. LeBrun, and Andrew V. Suarez

    PNAS December 26, 2007 104 (52) 20856-20861; https://doi.org/10.1073/pnas.0706903105
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    Spatial heterogeneity of mesopredator release within an oceanic island system

    Matt J. Rayner, Mark E. Hauber, Michael J. Imber, Rosalie K. Stamp, and Mick N. Clout

    PNAS December 26, 2007 104 (52) 20862-20865; https://doi.org/10.1073/pnas.0707414105
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    Cold- and exercise-induced peak metabolic rates in tropical birds

    Popko Wiersma, Mark A. Chappell, and Joseph B. Williams

    PNAS December 26, 2007 104 (52) 20866-20871; https://doi.org/10.1073/pnas.0707683104

• Genetics

  • Open Access

    Association of yeast Upf1p with direct substrates of the NMD pathway

    Marcus J. O. Johansson, Feng He, Phyllis Spatrick, Chunfang Li, and Allan Jacobson

    PNAS December 26, 2007 104 (52) 20872-20877; https://doi.org/10.1073/pnas.0709257105

• Immunology

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    Therapeutic B cell depletion impairs adaptive and autoreactive CD4⁺ T cell activation in mice

    Jean-David Bouaziz, Koichi Yanaba, Guglielmo M. Venturi, Yaming Wang, Roland M. Tisch, Jonathan C. Poe, and Thomas F. Tedder

    PNAS December 26, 2007 104 (52) 20878-20883; https://doi.org/10.1073/pnas.0709205105
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    Circulating tumor antigen-specific regulatory T cells in patients with metastatic melanoma

    Luis Vence, A. Karolina Palucka, Joseph W. Fay, Tomoki Ito, Yong-Jun Liu, Jacques Banchereau, and Hideki Ueno

    PNAS December 26, 2007 104 (52) 20884-20889; https://doi.org/10.1073/pnas.0710557105

• Medical Sciences

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    Endogenous circadian rhythm in human motor activity uncoupled from circadian influences on cardiac dynamics

    Plamen Ch. Ivanov, Kun Hu, Michael F. Hilton, Steven A. Shea, and H. Eugene Stanley

    PNAS December 26, 2007 104 (52) 20702-20707; https://doi.org/10.1073/pnas.0709957104
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    The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology

    Kimberly M. Szymanski, Derk Binns, René Bartz, Nick V. Grishin, Wei-Ping Li, Anil K. Agarwal, Abhimanyu Garg, Richard G. W. Anderson, and Joel M. Goodman

    PNAS December 26, 2007 104 (52) 20890-20895; https://doi.org/10.1073/pnas.0704154104
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    An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus

    G. C. DeLuca, S. V. Ramagopalan, B. M. Herrera, D. A. Dyment, M. R. Lincoln, A. Montpetit, M. Pugliatti, M. C. N. Barnardo, N. J. Risch, A. D. Sadovnick, M. Chao, S. Sotgiu, T. J. Hudson, and G. C. Ebers

    PNAS December 26, 2007 104 (52) 20896-20901; https://doi.org/10.1073/pnas.0707731105
  • Open Access

    Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

    Josée Guirouilh-Barbat, Emilie Rass, Isabelle Plo, Pascale Bertrand, and Bernard S. Lopez

    PNAS December 26, 2007 104 (52) 20902-20907; https://doi.org/10.1073/pnas.0708541104
  • Open Access

    Prion strain discrimination in cell culture: The cell panel assay

    Sukhvir P. Mahal, Christopher A. Baker, Cheryl A. Demczyk, Emery W. Smith, Christian Julius, and Charles Weissmann

    PNAS December 26, 2007 104 (52) 20908-20913; https://doi.org/10.1073/pnas.0710054104
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    Prion detection by an amyloid seeding assay

    David W. Colby, Qiang Zhang, Shuyi Wang, Darlene Groth, Giuseppe Legname, Detlev Riesner, and Stanley B. Prusiner

    PNAS December 26, 2007 104 (52) 20914-20919; https://doi.org/10.1073/pnas.0710152105
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    Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance

    Nathan J. Robertson, Frances A. Brook, Richard L. Gardner, Stephen P. Cobbold, Herman Waldmann, and Paul J. Fairchild

    PNAS December 26, 2007 104 (52) 20920-20925; https://doi.org/10.1073/pnas.0710265105
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    Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk

    Atsushi Kaneda, Chiaochun J. Wang, Raymond Cheong, Winston Timp, Patrick Onyango, Bo Wen, Christine A. Iacobuzio-Donahue, Rolf Ohlsson, Rita Andraos, Mark A. Pearson, Alexei A. Sharov, Dan L. Longo, Minoru S. H. Ko, Andre Levchenko, and Andrew P. Feinberg

    PNAS December 26, 2007 104 (52) 20926-20931; https://doi.org/10.1073/pnas.0710359105
  • Open Access

    MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib

    James Bean, Cameron Brennan, Jin-Yuan Shih, Gregory Riely, Agnes Viale, Lu Wang, Dhananjay Chitale, Noriko Motoi, Janos Szoke, Stephen Broderick, Marissa Balak, Wen-Cheng Chang, Chong-Jen Yu, Adi Gazdar, Harvey Pass, Valerie Rusch, William Gerald, Shiu-Feng Huang, Pan-Chyr Yang, Vincent Miller, Marc Ladanyi, Chih-Hsin Yang, and William Pao

    PNAS December 26, 2007 104 (52) 20932-20937; https://doi.org/10.1073/pnas.0710370104
  • Open Access

    Staged in vitro reconstitution and implantation of engineered rat kidney tissue

    E. Rosines, R. V. Sampogna, K. Johkura, D. A. Vaughn, Y. Choi, H. Sakurai, M. M. Shah, and S. K. Nigam

    PNAS December 26, 2007 104 (52) 20938-20943; https://doi.org/10.1073/pnas.0710428105
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    GABA_A-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA_A “phasic” receptors

    Eleonora Palma, Cristina Roseti, Francesca Maiolino, Sergio Fucile, Katiuscia Martinello, Manuela Mazzuferi, Eleonora Aronica, Mario Manfredi, Vincenzo Esposito, Gianpaolo Cantore, Ricardo Miledi, Michele Simonato, and Fabrizio Eusebi

    PNAS December 26, 2007 104 (52) 20944-20948; https://doi.org/10.1073/pnas.0710522105

• Microbiology

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    Identification of H2N3 influenza A viruses from swine in the United States

    Wenjun Ma, Amy L. Vincent, Marie R. Gramer, Christy B. Brockwell, Kelly M. Lager, Bruce H. Janke, Phillip C. Gauger, Devi P. Patnayak, Richard J. Webby, and Jürgen A. Richt

    PNAS December 26, 2007 104 (52) 20949-20954; https://doi.org/10.1073/pnas.0710286104

• Neuroscience

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    Amygdala depotentiation and fear extinction

    Jeongyeon Kim, Sukwon Lee, Kyungjoon Park, Ingie Hong, Beomjong Song, Gihoon Son, Heewoo Park, Woon Ryoung Kim, Eunjin Park, Han Kyung Choe, Hyun Kim, Changjoong Lee, Woong Sun, Kyungjin Kim, Ki Soon Shin, and Sukwoo Choi

    PNAS December 26, 2007 104 (52) 20955-20960; https://doi.org/10.1073/pnas.0710548105
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    Evoked brain responses are generated by feedback loops

    Marta I. Garrido, James M. Kilner, Stefan J. Kiebel, and Karl J. Friston

    PNAS December 26, 2007 104 (52) 20961-20966; https://doi.org/10.1073/pnas.0706274105
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    Evidence for a vascular contribution to diffusion FMRI at high b value

    Karla L. Miller, Daniel P. Bulte, Hannah Devlin, Matthew D. Robson, Richard G. Wise, Mark W. Woolrich, Peter Jezzard, and Timothy E. J. Behrens

    PNAS December 26, 2007 104 (52) 20967-20972; https://doi.org/10.1073/pnas.0707257105
  • Open Access

    Nck adaptor proteins control the organization of neuronal circuits important for walking

    James P. Fawcett, John Georgiou, Julie Ruston, Friedhelm Bladt, Andrew Sherman, Neil Warner, Bechara J. Saab, Rizaldy Scott, John C. Roder, and Tony Pawson

    PNAS December 26, 2007 104 (52) 20973-20978; https://doi.org/10.1073/pnas.0710316105

• Pharmacology

  • Open Access

    Hematopoietic prostaglandin D₂ synthase controls the onset and resolution of acute inflammation through PGD₂ and 15-deoxyΔ^12–14 PGJ₂

    • From the Cover

    Ravindra Rajakariar, Mark Hilliard, Toby Lawrence, Seema Trivedi, Paul Colville-Nash, Geoff Bellingan, Desmond Fitzgerald, Muhammad M. Yaqoob, and Derek W. Gilroy

    PNAS December 26, 2007 104 (52) 20979-20984; https://doi.org/10.1073/pnas.0707394104

• Physiology

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    Universal scaling law of electrical turbulence in the mammalian heart

    Sami F. Noujaim, Omer Berenfeld, Jérôme Kalifa, Marina Cerrone, Kumaraswamy Nanthakumar, Felipe Atienza, Javier Moreno, Sergey Mironov, and José Jalife

    PNAS December 26, 2007 104 (52) 20985-20989; https://doi.org/10.1073/pnas.0709758104
  • Open Access

    Mutation of an A-kinase-anchoring protein causes long-QT syndrome

    Lei Chen, Michelle L. Marquardt, David J. Tester, Kevin J. Sampson, Michael J. Ackerman, and Robert S. Kass

    PNAS December 26, 2007 104 (52) 20990-20995; https://doi.org/10.1073/pnas.0710527105

• Plant Biology

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    Oscillations in extracellular pH and reactive oxygen species modulate tip growth of Arabidopsis root hairs

    • From the Cover

    G. B. Monshausen, T. N. Bibikova, M. A. Messerli, C. Shi, and S. Gilroy

    PNAS December 26, 2007 104 (52) 20996-21001; https://doi.org/10.1073/pnas.0708586104
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    Arabidopsis CBF1 and CBF3 have a different function than CBF2 in cold acclimation and define different gene classes in the CBF regulon

    Fernando Novillo, Joaquín Medina, and Julio Salinas

    PNAS December 26, 2007 104 (52) 21002-21007; https://doi.org/10.1073/pnas.0705639105
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    The subunit composition of hinokiresinol synthase controls geometrical selectivity in norlignan formation

    Shiro Suzuki, Masaomi Yamamura, Takefumi Hattori, Tomoyuki Nakatsubo, and Toshiaki Umezawa

    PNAS December 26, 2007 104 (52) 21008-21013; https://doi.org/10.1073/pnas.0710357105

• Psychology

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    Global topological dominance in the left hemisphere

    Bo Wang, Tian Gang Zhou, Yan Zhuo, and Lin Chen

    PNAS December 26, 2007 104 (52) 21014-21019; https://doi.org/10.1073/pnas.0709664104

• Sustainability Science

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    The evolution of urban sprawl: Evidence of spatial heterogeneity and increasing land fragmentation

    • From the Cover

    Elena G. Irwin and Nancy E. Bockstael

    PNAS December 26, 2007 104 (52) 20672-20677; https://doi.org/10.1073/pnas.0705527105
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    Incorporating plant functional diversity effects in ecosystem service assessments

    • Cozzarelli Prize Winner

    Sandra Díaz, Sandra Lavorel, Francesco de Bello, Fabien Quétier, Karl Grigulis, and T. Matthew Robson

    PNAS December 26, 2007 104 (52) 20684-20689; https://doi.org/10.1073/pnas.0704716104
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    Learning from episodes of degradation and recovery in variable Australian rangelands

    D. Mark Stafford Smith, Greg M. McKeon, Ian W. Watson, Beverley K. Henry, Grant S. Stone, Wayne B. Hall, and S. Mark Howden

    PNAS December 26, 2007 104 (52) 20690-20695; https://doi.org/10.1073/pnas.0704837104
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    Ecological feedbacks following deforestation create the potential for a catastrophic ecosystem shift in tropical dry forest

    Deborah Lawrence, Paolo D'Odorico, Lucy Diekmann, Marcia DeLonge, Rishiraj Das, and James Eaton

    PNAS December 26, 2007 104 (52) 20696-20701; https://doi.org/10.1073/pnas.0705005104