Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice

*Department of Immunology, Duke University Medical Center, Durham, NC 27710; and
^†Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599

Edited by Max D. Cooper, University of Alabama, Birmingham, AL, and approved November 5, 2007 (received for review September 28, 2007)

Footnotes

^‡To whom correspondence should be addressed:
Department of Immunology, Box 3010, Duke University Medical Center, Durham, NC 27710.
E-mail: thomas.tedder{at}duke.edu
Author contributions: J.-D.B. and K.Y. contributed equally to this work; J.-D.B., K.Y., J.C.P., and T.F.T. designed research; J.-D.B., K.Y., and G.M.V. performed research; J.-D.B., K.Y., and Y.W. contributed new reagents/analytic tools; J.-D.B., K.Y., R.M.T., J.C.P., and T.F.T. analyzed data; and J.-D.B., K.Y., G.M.V., R.M.T., J.C.P., and T.F.T. wrote the paper.
Conflict of interest statement: T.F.T. is a paid consultant for MedImmune, Inc. and a consultant and shareholder for Angelica Therapeutics, Inc. J.C.P is a paid consultant for Angelica Therapeutics, Inc.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/cgi/content/full/0709205105/DC1.

Cited By...

Article usage

Article usage: December 2007 to February 2021

	Abstract	Full	Pdf
Dec 2007	339	84	247
Total 2007	339	84	247
Jan 2008	290	310	412
Feb 2008	65	174	141
Mar 2008	89	90	92
Apr 2008	60	72	82
May 2008	63	81	76
Jun 2008	46	68	55
Jul 2008	131	34	32
Aug 2008	135	40	72
Sep 2008	253	21	39
Oct 2008	202	40	36
Nov 2008	83	26	88
Dec 2008	54	22	40
Total 2008	1471	978	1165
Jan 2009	76	45	35
Feb 2009	91	31	39
Mar 2009	37	47	41
Apr 2009	43	51	37
May 2009	47	50	28
Jun 2009	39	35	50
Jul 2009	38	32	27
Aug 2009	38	39	34
Sep 2009	48	35	31
Oct 2009	71	24	27
Nov 2009	47	27	30
Dec 2009	54	23	28
Total 2009	629	439	407
Jan 2010	56	25	45
Feb 2010	81	31	27
Mar 2010	42	37	21
Apr 2010	83	40	31
May 2010	93	36	26
Jun 2010	137	32	23
Jul 2010	139	26	16
Aug 2010	373	29	21
Sep 2010	44	41	35
Oct 2010	37	34	40
Nov 2010	46	43	43
Dec 2010	18	15	12
Total 2010	1149	389	340
Jan 2011	17	23	16
Feb 2011	24	24	19
Mar 2011	18	41	27
Apr 2011	19	30	17
May 2011	24	18	30
Jun 2011	25	16	22
Jul 2011	32	23	18
Aug 2011	16	13	12
Sep 2011	29	22	29
Oct 2011	37	23	27
Nov 2011	27	20	23
Dec 2011	32	14	27
Total 2011	300	267	267
Jan 2012	15	7	8
Feb 2012	15	8	9
Mar 2012	19	9	13
Apr 2012	17	20	5
May 2012	35	31	25
Jun 2012	35	19	11
Jul 2012	22	16	13
Aug 2012	18	15	11
Sep 2012	57	23	21
Oct 2012	28	12	10
Nov 2012	37	12	18
Dec 2012	23	13	13
Total 2012	321	185	157
Jan 2013	23	22	15
Feb 2013	23	20	14
Mar 2013	23	17	26
Apr 2013	22	17	10
May 2013	19	14	14
Jun 2013	29	20	21
Jul 2013	34	15	21
Aug 2013	22	15	17
Sep 2013	22	15	12
Oct 2013	37	38	18
Nov 2013	30	49	14
Dec 2013	28	22	15
Total 2013	312	264	197
Jan 2014	51	26	14
Feb 2014	25	28	15
Mar 2014	42	33	14
Apr 2014	33	31	16
May 2014	17	22	11
Jun 2014	43	32	14
Jul 2014	30	19	13
Aug 2014	35	52	11
Sep 2014	31	35	8
Oct 2014	38	39	16
Nov 2014	56	34	19
Dec 2014	41	19	7
Total 2014	442	370	158
Jan 2015	16	21	13
Feb 2015	19	19	4
Mar 2015	37	16	10
Apr 2015	32	23	16
May 2015	31	12	10
Jun 2015	29	19	14
Jul 2015	23	21	17
Aug 2015	19	18	11
Sep 2015	30	25	14
Oct 2015	18	26	12
Nov 2015	31	22	11
Dec 2015	45	15	14
Total 2015	330	237	146
Jan 2016	34	28	17
Feb 2016	19	28	13
Mar 2016	41	28	26
Apr 2016	29	20	17
May 2016	27	30	10
Jun 2016	36	14	14
Jul 2016	43	25	13
Aug 2016	40	21	13
Sep 2016	28	17	10
Oct 2016	40	20	11
Nov 2016	66	17	17
Dec 2016	56	12	16
Total 2016	459	260	177
Jan 2017	55	32	13
Feb 2017	36	18	13
Mar 2017	31	29	15
Apr 2017	26	20	10
May 2017	31	25	15
Jun 2017	33	13	17
Jul 2017	26	17	17
Aug 2017	20	15	19
Sep 2017	24	25	15
Oct 2017	32	23	18
Nov 2017	28	17	9
Dec 2017	22	15	13
Total 2017	364	249	174
Jan 2018	29	31	17
Feb 2018	33	38	24
Mar 2018	50	56	30
Apr 2018	76	73	10
May 2018	72	65	12
Jun 2018	61	61	13
Jul 2018	60	62	12
Aug 2018	40	47	9
Sep 2018	43	41	10
Oct 2018	8	63	11
Nov 2018	1	45	7
Dec 2018	4	39	12
Total 2018	477	621	167
Jan 2019	7	52	13
Feb 2019	1	39	7
Mar 2019	2	48	13
Apr 2019	14	58	23
May 2019	1	57	17
Jun 2019	1	29	9
Jul 2019	5	58	23
Aug 2019	4	56	12
Sep 2019	5	56	17
Oct 2019	9	70	24
Nov 2019	9	59	30
Dec 2019	2	44	16
Total 2019	60	626	204
Jan 2020	11	64	20
Feb 2020	3	49	18
Mar 2020	7	46	13
Apr 2020	6	47	31
May 2020	2	65	37
Jun 2020	4	48	17
Jul 2020	1	62	22
Aug 2020	11	58	21
Sep 2020	12	55	25
Oct 2020	4	77	24
Nov 2020	9	78	21
Dec 2020	8	62	24
Total 2020	78	711	273
Jan 2021	10	65	24
Feb 2021	14	61	23
Total 2021	24	126	47
Total	6755	5806	4126