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About the Cover

May 06, 2008; vol. 105 no. 18

This Week in PNAS

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    In This Issue
    PNAS May 6, 2008 105 (18) 6503-6504; https://doi.org/10.1073/iti1808105

    See companion article:

    • A polycyclic terpenoid that alleviates oxidative stress
      - Apr 24, 2008
    • Anemia and splenomegaly in cGKI-deficient mice
      - Apr 28, 2008
    • Selective targeting of ITK blocks multiple steps of HIV replication
      - Apr 28, 2008
    • The fetal liver is a niche for maturation of primitive erythroid cells
      - Apr 29, 2008

Commentary

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    Why conservation planning needs socioeconomic data
    Stephen Polasky
    PNAS May 6, 2008 105 (18) 6505-6506; https://doi.org/10.1073/pnas.0802815105

    See companion article:

    • Cost-effective global conservation spending is robust to taxonomic group
      - Apr 14, 2008

Perspective

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    What's the point of the type III secretion system needle?
    Ariel J. Blocker, Janet E. Deane, Andreas K. J. Veenendaal, Pietro Roversi, Julie L. Hodgkinson, Steven Johnson, and Susan M. Lea
    PNAS May 6, 2008 105 (18) 6507-6513; https://doi.org/10.1073/pnas.0708344105

Physical Sciences

  • Chemistry

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      Folding of a donor–acceptor polyrotaxane by using noncovalent bonding interactions
      Wenyu Zhang, William R. Dichtel, Adam Z. Stieg, Diego Benítez, James K. Gimzewski, James R. Heath, and J. Fraser Stoddart
      PNAS May 6, 2008 105 (18) 6514-6519; https://doi.org/10.1073/pnas.0711072105
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      Investigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNA
      Ram P. Garg, Xuelei L. Qian, Lawrence B. Alemany, Sean Moran, and Ronald J. Parry
      PNAS May 6, 2008 105 (18) 6543-6547; https://doi.org/10.1073/pnas.0708957105
  • Geology

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      Younger Dryas “black mats” and the Rancholabrean termination in North America
      C. Vance Haynes Jr
      PNAS May 6, 2008 105 (18) 6520-6525; https://doi.org/10.1073/pnas.0800560105
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      A polycyclic terpenoid that alleviates oxidative stress
      T. Bosak, R. M. Losick, and A. Pearson
      PNAS May 6, 2008 105 (18) 6725-6729; https://doi.org/10.1073/pnas.0800199105

      See companion article:

      • In This Issue
        - May 06, 2008
  • Geophysics

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      Prediction of an U2S3-type polymorph of Al2O3 at 3.7 Mbar
      Koichiro Umemoto and Renata M. Wentzcovitch
      PNAS May 6, 2008 105 (18) 6526-6530; https://doi.org/10.1073/pnas.0711925105

Biological Sciences

  • Applied Biological Sciences

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      Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
      Anura P. Jayasooriya, Michael L. Mathai, Lesley L. Walker, Denovan P. Begg, Derek A. Denton, David Cameron-Smith, Gary F. Egan, Michael J. McKinley, Paula D. Rodger, Andrew J. Sinclair, John D. Wark, Harrison S. Weisinger, Mark Jois, and Richard S. Weisinger
      PNAS May 6, 2008 105 (18) 6531-6536; https://doi.org/10.1073/pnas.0802690105
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      Cyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissue
      Zeeshan H. Syedain, Justin S. Weinberg, and Robert T. Tranquillo
      PNAS May 6, 2008 105 (18) 6537-6542; https://doi.org/10.1073/pnas.0711217105
  • Biochemistry

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      Investigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNA
      Ram P. Garg, Xuelei L. Qian, Lawrence B. Alemany, Sean Moran, and Ronald J. Parry
      PNAS May 6, 2008 105 (18) 6543-6547; https://doi.org/10.1073/pnas.0708957105
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      Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly
      Dirk Hubmacher, Ehab I. El-Hallous, Valentin Nelea, Mari T. Kaartinen, Eunice R. Lee, and Dieter P. Reinhardt
      PNAS May 6, 2008 105 (18) 6548-6553; https://doi.org/10.1073/pnas.0706335105
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      Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine
      Manas K. Chattopadhyay, Myung Hee Park, and Herbert Tabor
      PNAS May 6, 2008 105 (18) 6554-6559; https://doi.org/10.1073/pnas.0710970105
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      Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
      Elizabeth Ficko-Blean, Keith A. Stubbs, Oksana Nemirovsky, David J. Vocadlo, and Alisdair B. Boraston
      PNAS May 6, 2008 105 (18) 6560-6565; https://doi.org/10.1073/pnas.0711491105
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      The crystal structure and dimerization interface of GADD45γ
      Joseph D. Schrag, Sarn Jiralerspong, Myriam Banville, Maria Luz Jaramillo, and Maureen D. O'Connor-McCourt
      PNAS May 6, 2008 105 (18) 6566-6571; https://doi.org/10.1073/pnas.0800086105
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      Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase
      Andrea Alfieri, Enrico Malito, Roberto Orru, Marco W. Fraaije, and Andrea Mattevi
      PNAS May 6, 2008 105 (18) 6572-6577; https://doi.org/10.1073/pnas.0800859105
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      Design of protein function leaps by directed domain interface evolution
      Jin Huang, Akiko Koide, Koki Makabe, and Shohei Koide
      PNAS May 6, 2008 105 (18) 6578-6583; https://doi.org/10.1073/pnas.0801097105
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      Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
      Jidong Zhu, John Blenis, and Junying Yuan
      PNAS May 6, 2008 105 (18) 6584-6589; https://doi.org/10.1073/pnas.0802785105
  • Biophysics

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      Assembly mechanism of recombinant spider silk proteins
      • From the Cover
      S. Rammensee, U. Slotta, T. Scheibel, and A. R. Bausch
      PNAS May 6, 2008 105 (18) 6590-6595; https://doi.org/10.1073/pnas.0709246105
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      Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Förster resonance energy transfer imaging
      Hongtao Chen, Sungwon Kim, Li Li, Shuyi Wang, Kinam Park, and Ji-Xin Cheng
      PNAS May 6, 2008 105 (18) 6596-6601; https://doi.org/10.1073/pnas.0707046105
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      Single-molecule nonequilibrium periodic Mg2+-concentration jump experiments reveal details of the early folding pathways of a large RNA
      Xiaohui Qu, Glenna J. Smith, Kang Taek Lee, Tobin R. Sosnick, Tao Pan, and Norbert F. Scherer
      PNAS May 6, 2008 105 (18) 6602-6607; https://doi.org/10.1073/pnas.0801436105
  • Cell Biology

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      Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
      Bernhard Schmierer, Alexander L. Tournier, Paul A. Bates, and Caroline S. Hill
      PNAS May 6, 2008 105 (18) 6608-6613; https://doi.org/10.1073/pnas.0710134105
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      β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells
      Noriyuki Sonoda, Takeshi Imamura, Takeshi Yoshizaki, Jennie L. Babendure, Juu-Chin Lu, and Jerrold M. Olefsky
      PNAS May 6, 2008 105 (18) 6614-6619; https://doi.org/10.1073/pnas.0710402105
    • Open Access
      Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
      Susanna Purhonen, Jarmo Palm, Derrick Rossi, Nina Kaskenpää, Iiro Rajantie, Seppo Ylä-Herttuala, Kari Alitalo, Irving L. Weissman, and Petri Salven
      PNAS May 6, 2008 105 (18) 6620-6625; https://doi.org/10.1073/pnas.0710516105
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      Rapid signal transduction in living cells is a unique feature of mechanotransduction
      Sungsoo Na, Olivier Collin, Farhan Chowdhury, Bernard Tay, Mingxing Ouyang, Yingxiao Wang, and Ning Wang
      PNAS May 6, 2008 105 (18) 6626-6631; https://doi.org/10.1073/pnas.0711704105
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      Phenotypic transcription factors epigenetically mediate cell growth control
      Syed A. Ali, Sayyed K. Zaidi, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, Abdul R. Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein
      PNAS May 6, 2008 105 (18) 6632-6637; https://doi.org/10.1073/pnas.0800970105
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      Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice
      Xu Peng, Xiaoyang Wu, Joseph E. Druso, Huijun Wei, Ann Yong-Jin Park, Marc S. Kraus, Ana Alcaraz, Ju Chen, Shu Chien, Richard A. Cerione, and Jun-Lin Guan
      PNAS May 6, 2008 105 (18) 6638-6643; https://doi.org/10.1073/pnas.0802319105
  • Developmental Biology

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      Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
      Inés Carrera, Florence Janody, Nina Leeds, Fabien Duveau, and Jessica E. Treisman
      PNAS May 6, 2008 105 (18) 6644-6649; https://doi.org/10.1073/pnas.0709749105
    • Open Access
      Functional specialization among insect chitinase family genes revealed by RNA interference
      Qingsong Zhu, Yasuyuki Arakane, Richard W. Beeman, Karl J. Kramer, and Subbaratnam Muthukrishnan
      PNAS May 6, 2008 105 (18) 6650-6655; https://doi.org/10.1073/pnas.0800739105
    • You have access
      ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
      Xiaolin Gao, Peri Tate, Ping Hu, Robert Tjian, William C. Skarnes, and Zhong Wang
      PNAS May 6, 2008 105 (18) 6656-6661; https://doi.org/10.1073/pnas.0801802105
    • You have access
      The fetal liver is a niche for maturation of primitive erythroid cells
      Joan Isern, Stuart T. Fraser, Zhiyong He, and Margaret H. Baron
      PNAS May 6, 2008 105 (18) 6662-6667; https://doi.org/10.1073/pnas.0802032105

      See companion article:

      • In This Issue
        - May 06, 2008
  • Environmental Sciences

    • Open Access
      Impacts of climate warming on terrestrial ectotherms across latitude
      • From the Cover
      Curtis A. Deutsch, Joshua J. Tewksbury, Raymond B. Huey, Kimberly S. Sheldon, Cameron K. Ghalambor, David C. Haak, and Paul R. Martin
      PNAS May 6, 2008 105 (18) 6668-6672; https://doi.org/10.1073/pnas.0709472105
    • Open Access
      On the protection of “protected areas”
      Lucas N. Joppa, Scott R. Loarie, and Stuart L. Pimm
      PNAS May 6, 2008 105 (18) 6673-6678; https://doi.org/10.1073/pnas.0802471105
  • Evolution

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      Noncanonical role of Hox14 revealed by its expression patterns in lamprey and shark
      Shigehiro Kuraku, Yoko Takio, Koji Tamura, Hideaki Aono, Axel Meyer, and Shigeru Kuratani
      PNAS May 6, 2008 105 (18) 6679-6683; https://doi.org/10.1073/pnas.0710947105
  • Immunology

    • Open Access
      Selective targeting of ITK blocks multiple steps of HIV replication
      Julie A. Readinger, Gillian M. Schiralli, Jian-Kang Jiang, Craig J. Thomas, Avery August, Andrew J. Henderson, and Pamela L. Schwartzberg
      PNAS May 6, 2008 105 (18) 6684-6689; https://doi.org/10.1073/pnas.0709659105

      See companion article:

      • In This Issue
        - May 06, 2008
    • You have access
      Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
      Hui Xu, Timothy B. Oriss, Mingjian Fei, Adam C. Henry, Barbro N. Melgert, Li Chen, Andrew L. Mellor, David H. Munn, Charles G. Irvin, Prabir Ray, and Anuradha Ray
      PNAS May 6, 2008 105 (18) 6690-6695; https://doi.org/10.1073/pnas.0708809105
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      Structural basis for NKG2A/CD94 recognition of HLA-E
      Brett K. Kaiser, Juan Carlos Pizarro, Julie Kerns, and Roland K. Strong
      PNAS May 6, 2008 105 (18) 6696-6701; https://doi.org/10.1073/pnas.0802736105
  • Medical Sciences

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      High blood pressure arising from a defect in vascular function
      Simon K. Michael, Howard K. Surks, Yuepeng Wang, Yan Zhu, Robert Blanton, Michelle Jamnongjit, Mark Aronovitz, Wendy Baur, Kenichi Ohtani, Michael K. Wilkerson, Adrian D. Bonev, Mark T. Nelson, Richard H. Karas, and Michael E. Mendelsohn
      PNAS May 6, 2008 105 (18) 6702-6707; https://doi.org/10.1073/pnas.0802128105
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      Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease
      Kajsa Paulsson, Jean-Baptiste Cazier, Finlay MacDougall, Jane Stevens, Irina Stasevich, Nikoletta Vrcelj, Tracy Chaplin, Debra M. Lillington, T. Andrew Lister, and Bryan D. Young
      PNAS May 6, 2008 105 (18) 6708-6713; https://doi.org/10.1073/pnas.0800408105
    • Open Access
      Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndrome
      Jonathan L. Tobin, Matt Di Franco, Erica Eichers, Helen May-Simera, Monica Garcia, Jiong Yan, Robyn Quinlan, Monica J. Justice, Raoul C. Hennekam, James Briscoe, Masazumi Tada, Roberto Mayor, Alan J. Burns, James R. Lupski, Peter Hammond, and Philip L. Beales
      PNAS May 6, 2008 105 (18) 6714-6719; https://doi.org/10.1073/pnas.0707057105
    • You have access
      Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology
      Mitsuru Matsumoto, Yiqing Zhou, Shinji Matsuo, Hideki Nakanishi, Kenji Hirose, Hajimu Oura, Seiji Arase, Akemi Ishida-Yamamoto, Yoshimi Bando, Keisuke Izumi, Hiroshi Kiyonari, Naoko Oshima, Rika Nakayama, Akemi Matsushima, Fumiko Hirota, Yasuhiro Mouri, Noriyuki Kuroda, Shigetoshi Sano, and David D. Chaplin
      PNAS May 6, 2008 105 (18) 6720-6724; https://doi.org/10.1073/pnas.0709345105
  • Microbiology

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      A polycyclic terpenoid that alleviates oxidative stress
      T. Bosak, R. M. Losick, and A. Pearson
      PNAS May 6, 2008 105 (18) 6725-6729; https://doi.org/10.1073/pnas.0800199105

      See companion article:

      • In This Issue
        - May 06, 2008
    • You have access
      Extreme polyploidy in a large bacterium
      • From the Cover
      Jennifer E. Mendell, Kendall D. Clements, J. Howard Choat, and Esther R. Angert
      PNAS May 6, 2008 105 (18) 6730-6734; https://doi.org/10.1073/pnas.0707522105
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      Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways
      Melinda J. Faulkner, Karthik Veeravalli, Stéphanie Gon, George Georgiou, and Jon Beckwith
      PNAS May 6, 2008 105 (18) 6735-6740; https://doi.org/10.1073/pnas.0801986105
  • Neuroscience

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      Neural correlates of mentalizing-related computations during strategic interactions in humans
      Alan N. Hampton, Peter Bossaerts, and John P. O'Doherty
      PNAS May 6, 2008 105 (18) 6741-6746; https://doi.org/10.1073/pnas.0711099105
    • Open Access
      Simulation of talking faces in the human brain improves auditory speech recognition
      • From the Cover
      Katharina von Kriegstein, Özgür Dogan, Martina Grüter, Anne-Lise Giraud, Christian A. Kell, Thomas Grüter, Andreas Kleinschmidt, and Stefan J. Kiebel
      PNAS May 6, 2008 105 (18) 6747-6752; https://doi.org/10.1073/pnas.0710826105
    • Open Access
      Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions
      Wolfram Wetzel, Frank W. Ohl, and Henning Scheich
      PNAS May 6, 2008 105 (18) 6753-6758; https://doi.org/10.1073/pnas.0707844105
    • Open Access
      The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI
      Alexander Rauch, Gregor Rainer, and Nikos K. Logothetis
      PNAS May 6, 2008 105 (18) 6759-6764; https://doi.org/10.1073/pnas.0800312105
    • You have access
      Modular patterning of structure and function of the striatum by retinoid receptor signaling
      Wen-Lin Liao, Hsiu-Chao Tsai, Hsiao-Fang Wang, Josephine Chang, Kuan-Ming Lu, Hsiao-Lin Wu, Yi-Chao Lee, Ting-Fen Tsai, Hiroshi Takahashi, Michael Wagner, Norbert B. Ghyselinck, Pierre Chambon, and Fu-Chin Liu
      PNAS May 6, 2008 105 (18) 6765-6770; https://doi.org/10.1073/pnas.0802109105
  • Physiology

    • You have access
      Anemia and splenomegaly in cGKI-deficient mice
      Michael Föller, Susanne Feil, Kamran Ghoreschi, Saisudha Koka, Andrea Gerling, Martin Thunemann, Franz Hofmann, Beat Schuler, Johannes Vogel, Bernd Pichler, Ravi S. Kasinathan, Jan P. Nicolay, Stephan M. Huber, Florian Lang, and Robert Feil
      PNAS May 6, 2008 105 (18) 6771-6776; https://doi.org/10.1073/pnas.0708940105

      See companion article:

      • In This Issue
        - May 06, 2008
    • You have access
      Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens
      Cheolho Sim and David L. Denlinger
      PNAS May 6, 2008 105 (18) 6777-6781; https://doi.org/10.1073/pnas.0802067105
  • Plant Biology

    • Open Access
      Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
      • From the Cover
      Supaart Sirikantaramas, Mami Yamazaki, and Kazuki Saito
      PNAS May 6, 2008 105 (18) 6782-6786; https://doi.org/10.1073/pnas.0801038105

Corrections

  • You have access
    Correction for Assarsson et al., Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes
    PNAS May 6, 2008 105 (18) 6787; https://doi.org/10.1073/pnas.0803050105
  • You have access
    Correction for Möglich et al., End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation
    PNAS May 6, 2008 105 (18) 6787; https://doi.org/10.1073/pnas.0803144105
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