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About the Cover
May 06, 2008; vol. 105 no. 18
This Week in PNAS
- You have accessIn This Issue
See companion article:
- A polycyclic terpenoid that alleviates oxidative stress- Apr 24, 2008
- Anemia and splenomegaly in cGKI-deficient mice- Apr 28, 2008
Perspective
- You have accessWhat's the point of the type III secretion system needle?Ariel J. Blocker, Janet E. Deane, Andreas K. J. Veenendaal, Pietro Roversi, Julie L. Hodgkinson, Steven Johnson, and Susan M. Lea
Physical Sciences
Chemistry
- You have accessFolding of a donor–acceptor polyrotaxane by using noncovalent bonding interactionsWenyu Zhang, William R. Dichtel, Adam Z. Stieg, Diego Benítez, James K. Gimzewski, James R. Heath, and J. Fraser Stoddart
- You have accessInvestigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNARam P. Garg, Xuelei L. Qian, Lawrence B. Alemany, Sean Moran, and Ronald J. Parry
Geology
- You have accessYounger Dryas “black mats” and the Rancholabrean termination in North AmericaC. Vance Haynes Jr
- You have accessA polycyclic terpenoid that alleviates oxidative stressT. Bosak, R. M. Losick, and A. Pearson
See companion article:
- In This Issue- May 06, 2008
Geophysics
- You have accessPrediction of an U2S3-type polymorph of Al2O3 at 3.7 MbarKoichiro Umemoto and Renata M. Wentzcovitch
Biological Sciences
Applied Biological Sciences
- You have accessMice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearanceAnura P. Jayasooriya, Michael L. Mathai, Lesley L. Walker, Denovan P. Begg, Derek A. Denton, David Cameron-Smith, Gary F. Egan, Michael J. McKinley, Paula D. Rodger, Andrew J. Sinclair, John D. Wark, Harrison S. Weisinger, Mark Jois, and Richard S. Weisinger
- You have accessCyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissueZeeshan H. Syedain, Justin S. Weinberg, and Robert T. Tranquillo
Biochemistry
- You have accessInvestigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNARam P. Garg, Xuelei L. Qian, Lawrence B. Alemany, Sean Moran, and Ronald J. Parry
- You have accessBiogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assemblyDirk Hubmacher, Ehab I. El-Hallous, Valentin Nelea, Mari T. Kaartinen, Eunice R. Lee, and Dieter P. Reinhardt
- You have accessHypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidineManas K. Chattopadhyay, Myung Hee Park, and Herbert Tabor
- You have accessStructural and mechanistic insight into the basis of mucopolysaccharidosis IIIBElizabeth Ficko-Blean, Keith A. Stubbs, Oksana Nemirovsky, David J. Vocadlo, and Alisdair B. Boraston
- You have accessThe crystal structure and dimerization interface of GADD45γJoseph D. Schrag, Sarn Jiralerspong, Myriam Banville, Maria Luz Jaramillo, and Maureen D. O'Connor-McCourt
- You have accessRevealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenaseAndrea Alfieri, Enrico Malito, Roberto Orru, Marco W. Fraaije, and Andrea Mattevi
- You have accessDesign of protein function leaps by directed domain interface evolutionJin Huang, Akiko Koide, Koki Makabe, and Shohei Koide
- You have accessActivation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1Jidong Zhu, John Blenis, and Junying Yuan
Biophysics
- You have accessAssembly mechanism of recombinant spider silk proteins
- From the Cover
S. Rammensee, U. Slotta, T. Scheibel, and A. R. Bausch - You have accessRelease of hydrophobic molecules from polymer micelles into cell membranes revealed by Förster resonance energy transfer imagingHongtao Chen, Sungwon Kim, Li Li, Shuyi Wang, Kinam Park, and Ji-Xin Cheng
- You have accessSingle-molecule nonequilibrium periodic Mg2+-concentration jump experiments reveal details of the early folding pathways of a large RNAXiaohui Qu, Glenna J. Smith, Kang Taek Lee, Tobin R. Sosnick, Tao Pan, and Norbert F. Scherer
Cell Biology
- You have accessMathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting systemBernhard Schmierer, Alexander L. Tournier, Paul A. Bates, and Caroline S. Hill
- You have accessβ-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cellsNoriyuki Sonoda, Takeshi Imamura, Takeshi Yoshizaki, Jennie L. Babendure, Juu-Chin Lu, and Jerrold M. Olefsky
- Open AccessBone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growthSusanna Purhonen, Jarmo Palm, Derrick Rossi, Nina Kaskenpää, Iiro Rajantie, Seppo Ylä-Herttuala, Kari Alitalo, Irving L. Weissman, and Petri Salven
- You have accessRapid signal transduction in living cells is a unique feature of mechanotransductionSungsoo Na, Olivier Collin, Farhan Chowdhury, Bernard Tay, Mingxing Ouyang, Yingxiao Wang, and Ning Wang
- You have accessPhenotypic transcription factors epigenetically mediate cell growth controlSyed A. Ali, Sayyed K. Zaidi, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, Abdul R. Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein
- You have accessCardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout miceXu Peng, Xiaoyang Wu, Joseph E. Druso, Huijun Wei, Ann Yong-Jin Park, Marc S. Kraus, Ana Alcaraz, Ju Chen, Shu Chien, Richard A. Cerione, and Jun-Lin Guan
Developmental Biology
- You have accessPygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13Inés Carrera, Florence Janody, Nina Leeds, Fabien Duveau, and Jessica E. Treisman
- Open AccessFunctional specialization among insect chitinase family genes revealed by RNA interferenceQingsong Zhu, Yasuyuki Arakane, Richard W. Beeman, Karl J. Kramer, and Subbaratnam Muthukrishnan
- You have accessES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250aXiaolin Gao, Peri Tate, Ping Hu, Robert Tjian, William C. Skarnes, and Zhong Wang
- You have accessThe fetal liver is a niche for maturation of primitive erythroid cellsJoan Isern, Stuart T. Fraser, Zhiyong He, and Margaret H. Baron
See companion article:
- In This Issue- May 06, 2008
Environmental Sciences
- Open AccessImpacts of climate warming on terrestrial ectotherms across latitude
- From the Cover
Curtis A. Deutsch, Joshua J. Tewksbury, Raymond B. Huey, Kimberly S. Sheldon, Cameron K. Ghalambor, David C. Haak, and Paul R. Martin - Open AccessOn the protection of “protected areas”Lucas N. Joppa, Scott R. Loarie, and Stuart L. Pimm
Evolution
- You have accessNoncanonical role of Hox14 revealed by its expression patterns in lamprey and sharkShigehiro Kuraku, Yoko Takio, Koji Tamura, Hideaki Aono, Axel Meyer, and Shigeru Kuratani
Immunology
- Open AccessSelective targeting of ITK blocks multiple steps of HIV replicationJulie A. Readinger, Gillian M. Schiralli, Jian-Kang Jiang, Craig J. Thomas, Avery August, Andrew J. Henderson, and Pamela L. Schwartzberg
See companion article:
- In This Issue- May 06, 2008
- You have accessIndoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammationHui Xu, Timothy B. Oriss, Mingjian Fei, Adam C. Henry, Barbro N. Melgert, Li Chen, Andrew L. Mellor, David H. Munn, Charles G. Irvin, Prabir Ray, and Anuradha Ray
- You have accessStructural basis for NKG2A/CD94 recognition of HLA-EBrett K. Kaiser, Juan Carlos Pizarro, Julie Kerns, and Roland K. Strong
Medical Sciences
- You have accessHigh blood pressure arising from a defect in vascular functionSimon K. Michael, Howard K. Surks, Yuepeng Wang, Yan Zhu, Robert Blanton, Michelle Jamnongjit, Mark Aronovitz, Wendy Baur, Kenichi Ohtani, Michael K. Wilkerson, Adrian D. Bonev, Mark T. Nelson, Richard H. Karas, and Michael E. Mendelsohn
- You have accessMicrodeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric diseaseKajsa Paulsson, Jean-Baptiste Cazier, Finlay MacDougall, Jane Stevens, Irina Stasevich, Nikoletta Vrcelj, Tracy Chaplin, Debra M. Lillington, T. Andrew Lister, and Bryan D. Young
- Open AccessInhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndromeJonathan L. Tobin, Matt Di Franco, Erica Eichers, Helen May-Simera, Monica Garcia, Jiong Yan, Robyn Quinlan, Monica J. Justice, Raoul C. Hennekam, James Briscoe, Masazumi Tada, Roberto Mayor, Alan J. Burns, James R. Lupski, Peter Hammond, and Philip L. Beales
- You have accessTargeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiologyMitsuru Matsumoto, Yiqing Zhou, Shinji Matsuo, Hideki Nakanishi, Kenji Hirose, Hajimu Oura, Seiji Arase, Akemi Ishida-Yamamoto, Yoshimi Bando, Keisuke Izumi, Hiroshi Kiyonari, Naoko Oshima, Rika Nakayama, Akemi Matsushima, Fumiko Hirota, Yasuhiro Mouri, Noriyuki Kuroda, Shigetoshi Sano, and David D. Chaplin
Microbiology
- You have accessA polycyclic terpenoid that alleviates oxidative stressT. Bosak, R. M. Losick, and A. Pearson
See companion article:
- In This Issue- May 06, 2008
- You have accessExtreme polyploidy in a large bacterium
- From the Cover
Jennifer E. Mendell, Kendall D. Clements, J. Howard Choat, and Esther R. Angert - You have accessFunctional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathwaysMelinda J. Faulkner, Karthik Veeravalli, Stéphanie Gon, George Georgiou, and Jon Beckwith
Neuroscience
- You have accessNeural correlates of mentalizing-related computations during strategic interactions in humansAlan N. Hampton, Peter Bossaerts, and John P. O'Doherty
- Open AccessSimulation of talking faces in the human brain improves auditory speech recognition
- From the Cover
Katharina von Kriegstein, Özgür Dogan, Martina Grüter, Anne-Lise Giraud, Christian A. Kell, Thomas Grüter, Andreas Kleinschmidt, and Stefan J. Kiebel - Open AccessGlobal versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functionsWolfram Wetzel, Frank W. Ohl, and Henning Scheich
- Open AccessThe effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRIAlexander Rauch, Gregor Rainer, and Nikos K. Logothetis
- You have accessModular patterning of structure and function of the striatum by retinoid receptor signalingWen-Lin Liao, Hsiu-Chao Tsai, Hsiao-Fang Wang, Josephine Chang, Kuan-Ming Lu, Hsiao-Lin Wu, Yi-Chao Lee, Ting-Fen Tsai, Hiroshi Takahashi, Michael Wagner, Norbert B. Ghyselinck, Pierre Chambon, and Fu-Chin Liu
Physiology
- You have accessAnemia and splenomegaly in cGKI-deficient miceMichael Föller, Susanne Feil, Kamran Ghoreschi, Saisudha Koka, Andrea Gerling, Martin Thunemann, Franz Hofmann, Beat Schuler, Johannes Vogel, Bernd Pichler, Ravi S. Kasinathan, Jan P. Nicolay, Stephan M. Huber, Florian Lang, and Robert Feil
See companion article:
- In This Issue- May 06, 2008
- You have accessInsulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiensCheolho Sim and David L. Denlinger
Plant Biology
- Open AccessMutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
- From the Cover
Supaart Sirikantaramas, Mami Yamazaki, and Kazuki Saito
Commentary
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