Table of Contents

Biological Sciences

• Anthropology

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    Unlocking evidence of early diet from tooth enamel

    Louise T. Humphrey, M. Christopher Dean, Teresa E. Jeffries, and Malcolm Penn

    PNAS May 13, 2008 105 (19) 6834-6839; https://doi.org/10.1073/pnas.0711513105

• Applied Biological Sciences

  • Open Access

    Endochondral bone tissue engineering using embryonic stem cells

    Jojanneke M. Jukes, Sanne K. Both, Anouk Leusink, Lotus M. Th. Sterk, Clemens A. van Blitterswijk, and Jan de Boer

    PNAS May 13, 2008 105 (19) 6840-6845; https://doi.org/10.1073/pnas.0711662105

• Biochemistry

  • Open Access

    Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells

    Jong-Heum Park, Dipti Mangal, Kirk A. Tacka, Amy M. Quinn, Ronald G. Harvey, Ian A. Blair, and Trevor M. Penning

    PNAS May 13, 2008 105 (19) 6846-6851; https://doi.org/10.1073/pnas.0802776105
  • Open Access

    Regression supports two mechanisms of fork processing in phage T4

    David T. Long and Kenneth N. Kreuzer

    PNAS May 13, 2008 105 (19) 6852-6857; https://doi.org/10.1073/pnas.0711999105
  • Open Access

    In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

    Yoo Seong Choi, Houjin Zhang, Joseph S. Brunzelle, Satish K. Nair, and Huimin Zhao

    PNAS May 13, 2008 105 (19) 6858-6863; https://doi.org/10.1073/pnas.0712073105
  • Open Access

    Cis- and trans-splicing of mRNAs mediated by tRNA sequences in eukaryotic cells

    • From the Cover

    Gianfranco Di Segni, Serena Gastaldi, and Glauco P. Tocchini-Valentini

    PNAS May 13, 2008 105 (19) 6864-6869; https://doi.org/10.1073/pnas.0800420105

    See companion article:

    • Long-distance splicing

      - May 12, 2008
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    Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling

    Nicole Lerner-Marmarosh, Tihomir Miralem, Peter E. M. Gibbs, and Mahin D. Maines

    PNAS May 13, 2008 105 (19) 6870-6875; https://doi.org/10.1073/pnas.0800750105
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    Structure of a TrmA–RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m⁵U methyltransferases

    Akram Alian, Tom T. Lee, Sarah L. Griner, Robert M. Stroud, and Janet Finer-Moore

    PNAS May 13, 2008 105 (19) 6876-6881; https://doi.org/10.1073/pnas.0802247105
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    Structural insight into signal conversion and inactivation by NTPDase2 in purinergic signaling

    Matthias Zebisch and Norbert Sträter

    PNAS May 13, 2008 105 (19) 6882-6887; https://doi.org/10.1073/pnas.0802535105

• Biophysics

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    Terahertz radiation from bacteriorhodopsin reveals correlated primary electron and proton transfer processes

    G. I. Groma, J. Hebling, I. Z. Kozma, G. Váró, J. Hauer, J. Kuhl, and E. Riedle

    PNAS May 13, 2008 105 (19) 6888-6893; https://doi.org/10.1073/pnas.0706336105
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    Dynamics of phosphodiester synthesis by DNA ligase

    Aurélien Crut, Pravin A. Nair, Daniel A. Koster, Stewart Shuman, and Nynke H. Dekker

    PNAS May 13, 2008 105 (19) 6894-6899; https://doi.org/10.1073/pnas.0800113105
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    Molecular mechanism of pH sensing in KcsA potassium channels

    Ameer N. Thompson, David J. Posson, Pirooz V. Parsa, and Crina M. Nimigean

    PNAS May 13, 2008 105 (19) 6900-6905; https://doi.org/10.1073/pnas.0800873105
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    Force-induced growth of adhesion domains is controlled by receptor mobility

    Ana-Sunčana Smith, Kheya Sengupta, Stefanie Goennenwein, Udo Seifert, and Erich Sackmann

    PNAS May 13, 2008 105 (19) 6906-6911; https://doi.org/10.1073/pnas.0801706105

• Cell Biology

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    Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

    Carrie A. Stoltzman, Christopher W. Peterson, Kevin T. Breen, Deborah M. Muoio, Andrew N. Billin, and Donald E. Ayer

    PNAS May 13, 2008 105 (19) 6912-6917; https://doi.org/10.1073/pnas.0712199105
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    Different assemblies of the DAM1 complex follow shortening microtubules by distinct mechanisms

    E. L. Grishchuk, I. S. Spiridonov, V. A. Volkov, A. Efremov, S. Westermann, D. Drubin, G. Barnes, F. I. Ataullakhanov, and J. R. McIntosh

    PNAS May 13, 2008 105 (19) 6918-6923; https://doi.org/10.1073/pnas.0801811105
  • Open Access

    Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8

    Kongming Wu, Sanjay Katiyar, Anping Li, Manran Liu, Xiaoming Ju, Vladimir M. Popov, Xuanmao Jiao, Michael P. Lisanti, Antonella Casola, and Richard G. Pestell

    PNAS May 13, 2008 105 (19) 6924-6929; https://doi.org/10.1073/pnas.0802085105
  • Open Access

    Influence of genotype and nutrition on survival and metabolism of starving yeast

    Viktor M. Boer, Sasan Amini, and David Botstein

    PNAS May 13, 2008 105 (19) 6930-6935; https://doi.org/10.1073/pnas.0802601105

• Developmental Biology

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    Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix

    Chi Zhang, Kyucheol Cho, Yehong Huang, Jon P. Lyons, Xin Zhou, Krishna Sinha, Pierre D. McCrea, and Benoit de Crombrugghe

    PNAS May 13, 2008 105 (19) 6936-6941; https://doi.org/10.1073/pnas.0710831105
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    Gene-regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2

    Xiuqian Mu, Xueyao Fu, Phillip D. Beremand, Terry L. Thomas, and William H. Klein

    PNAS May 13, 2008 105 (19) 6942-6947; https://doi.org/10.1073/pnas.0802627105

• Ecology

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    Quorum decision-making facilitates information transfer in fish shoals

    • From the Cover

    Ashley J. W. Ward, David J. T. Sumpter, Iain D. Couzin, Paul J. B. Hart, and Jens Krause

    PNAS May 13, 2008 105 (19) 6948-6953; https://doi.org/10.1073/pnas.0710344105

• Environmental Sciences

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    Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry

    Frithjof C. Küpper, Lucy J. Carpenter, Gordon B. McFiggans, Carl J. Palmer, Tim J. Waite, Eva-Maria Boneberg, Sonja Woitsch, Markus Weiller, Rafael Abela, Daniel Grolimund, Philippe Potin, Alison Butler, George W. Luther III, Peter M. H. Kroneck, Wolfram Meyer-Klaucke, and Martin C. Feiters

    PNAS May 13, 2008 105 (19) 6954-6958; https://doi.org/10.1073/pnas.0709959105

• Evolution

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    Estimating the size of the human interactome

    • From the Cover

    Michael P. H. Stumpf, Thomas Thorne, Eric de Silva, Ronald Stewart, Hyeong Jun An, Michael Lappe, and Carsten Wiuf

    PNAS May 13, 2008 105 (19) 6959-6964; https://doi.org/10.1073/pnas.0708078105

    See companion article:

    • A truer measure of our ignorance

      - May 12, 2008
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    Direct phylogenetic evidence for lateral transfer of elongation factor-like gene

    Ryoma Kamikawa, Yuji Inagaki, and Yoshihiko Sako

    PNAS May 13, 2008 105 (19) 6965-6969; https://doi.org/10.1073/pnas.0711084105
  • Open Access

    Arbovirus evolution in vivo is constrained by host alternation

    Lark L. Coffey, Nikos Vasilakis, Aaron C. Brault, Ann M. Powers, Frédéric Tripet, and Scott C. Weaver

    PNAS May 13, 2008 105 (19) 6970-6975; https://doi.org/10.1073/pnas.0712130105
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    The evolution of modularity in bacterial metabolic networks

    Anat Kreimer, Elhanan Borenstein, Uri Gophna, and Eytan Ruppin

    PNAS May 13, 2008 105 (19) 6976-6981; https://doi.org/10.1073/pnas.0712149105
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    Selfishness as second-order altruism

    Omar Tonsi Eldakar and David Sloan Wilson

    PNAS May 13, 2008 105 (19) 6982-6986; https://doi.org/10.1073/pnas.0712173105
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    Null mutations in human and mouse orthologs frequently result in different phenotypes

    Ben-Yang Liao and Jianzhi Zhang

    PNAS May 13, 2008 105 (19) 6987-6992; https://doi.org/10.1073/pnas.0800387105
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    Centrosomal RNA correlates with intron-poor nuclear genes in Spisula oocytes

    Mark C. Alliegro and Mary Anne Alliegro

    PNAS May 13, 2008 105 (19) 6993-6997; https://doi.org/10.1073/pnas.0802293105

• Genetics

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    Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications

    Zongzhong Tong, Zhenglin Yang, Shrena Patel, Haoyu Chen, Daniel Gibbs, Xian Yang, Vincent S. Hau, Yuuki Kaminoh, Jennifer Harmon, Erik Pearson, Jeanette Buehler, Yuhong Chen, Baifeng Yu, Nicholas H. Tinkham, Norman A. Zabriskie, Jiexi Zeng, Ling Luo, Jennifer K. Sun, Manvi Prakash, Rola N. Hamam, Stephen Tonna, Ryan Constantine, Cecinio C. Ronquillo, SriniVas Sadda, Robert L. Avery, John M. Brand, Nyall London, Alfred L. Anduze, George L. King, Paul S. Bernstein, Scott Watkins, Genetics of Diabetes, and Diabetic Complication Study Groupn, Lynn B. Jorde, Dean Y. Li, Lloyd Paul Aiello, Martin R. Pollak, and Kang Zhang

    PNAS May 13, 2008 105 (19) 6998-7003; https://doi.org/10.1073/pnas.0800454105
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    Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

    Lin Zhang, Stefano Volinia, Tomas Bonome, George Adrian Calin, Joel Greshock, Nuo Yang, Chang-Gong Liu, Antonis Giannakakis, Pangiotis Alexiou, Kosei Hasegawa, Cameron N. Johnstone, Molly S. Megraw, Sarah Adams, Heini Lassus, Jia Huang, Sippy Kaur, Shun Liang, Praveen Sethupathy, Arto Leminen, Victor A. Simossis, Raphael Sandaltzopoulos, Yoshio Naomoto, Dionyssios Katsaros, Phyllis A. Gimotty, Angela DeMichele, Qihong Huang, Ralf Bützow, Anil K. Rustgi, Barbara L. Weber, Michael J. Birrer, Artemis G. Hatzigeorgiou, Carlo M. Croce, and George Coukos

    PNAS May 13, 2008 105 (19) 7004-7009; https://doi.org/10.1073/pnas.0801615105

• Immunology

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    Dendritic cell-mediated NK cell activation is controlled by Jagged2–Notch interaction

    Mika Kijima, Takeshi Yamaguchi, Chieko Ishifune, Yoichi Maekawa, Akemi Koyanagi, Hideo Yagita, Shigeru Chiba, Kenji Kishihara, Mitsuo Shimada, and Koji Yasutomo

    PNAS May 13, 2008 105 (19) 7010-7015; https://doi.org/10.1073/pnas.0709919105
  • Open Access

    Identification of innate immunity genes and pathways using a comparative genomics approach

    Scott Alper, Rebecca Laws, Brad Lackford, Windy A. Boyd, Paul Dunlap, Jonathan H. Freedman, and David A. Schwartz

    PNAS May 13, 2008 105 (19) 7016-7021; https://doi.org/10.1073/pnas.0802405105

• Medical Sciences

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    Expression of an estrogen receptor agonist in differentiating osteoblast cultures

    Thomas L. McCarthy, Mary E. Clough, Caren M. Gundberg, and Michael Centrella

    PNAS May 13, 2008 105 (19) 7022-7027; https://doi.org/10.1073/pnas.0800085105
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    Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency

    M. Khairallah, R. J. Khairallah, M. E. Young, B. G. Allen, M. A. Gillis, G. Danialou, C. F. Deschepper, B. J. Petrof, and C. Des Rosiers

    PNAS May 13, 2008 105 (19) 7028-7033; https://doi.org/10.1073/pnas.0710595105

    See companion article:

    • In This Issue

      - May 13, 2008
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    Interferon signaling and treatment outcome in chronic hepatitis C

    Magdalena Sarasin-Filipowicz, Edward J. Oakeley, Francois H. T. Duong, Verena Christen, Luigi Terracciano, Witold Filipowicz, and Markus H. Heim

    PNAS May 13, 2008 105 (19) 7034-7039; https://doi.org/10.1073/pnas.0707882105
  • Open Access

    The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression

    Reena Shakya, Matthias Szabolcs, Ellen McCarthy, Elson Ospina, Katia Basso, Subhadra Nandula, Vundavalli Murty, Richard Baer, and Thomas Ludwig

    PNAS May 13, 2008 105 (19) 7040-7045; https://doi.org/10.1073/pnas.0711032105
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    Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair

    Brett G. Zani, Koji Kojima, Charles A. Vacanti, and Elazer R. Edelman

    PNAS May 13, 2008 105 (19) 7046-7051; https://doi.org/10.1073/pnas.0802463105

• Microbiology

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    Diverse syntrophic partnerships from deep-sea methane vents revealed by direct cell capture and metagenomics

    Annelie Pernthaler, Anne E. Dekas, C. Titus Brown, Shana K. Goffredi, Tsegereda Embaye, and Victoria J. Orphan

    PNAS May 13, 2008 105 (19) 7052-7057; https://doi.org/10.1073/pnas.0711303105

    See companion article:

    • In This Issue

      - May 13, 2008
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    Host and invader impact of transfer of the clc genomic island into Pseudomonas aeruginosa PAO1

    Muriel Gaillard, Nataskha Pernet, Christelle Vogne, Otto Hagenbüchle, and Jan Roelof van der Meer

    PNAS May 13, 2008 105 (19) 7058-7063; https://doi.org/10.1073/pnas.0801269105
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    Rhizobium cellulase CelC2 is essential for primary symbiotic infection of legume host roots

    M. Robledo, J. I. Jiménez-Zurdo, E. Velázquez, M. E. Trujillo, J. L. Zurdo-Piñeiro, M. H. Ramírez-Bahena, B. Ramos, J. M. Díaz-Mínguez, F. Dazzo, E. Martínez-Molina, and P. F. Mateos

    PNAS May 13, 2008 105 (19) 7064-7069; https://doi.org/10.1073/pnas.0802547105

• Neuroscience

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    Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

    Yufeng Yang, Yingshi Ouyang, Lichuan Yang, M. Flint Beal, Angus McQuibban, Hannes Vogel, and Bingwei Lu

    PNAS May 13, 2008 105 (19) 7070-7075; https://doi.org/10.1073/pnas.0711845105
  • Open Access

    A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

    Mirna Kvajo, Heather McKellar, P. Alexander Arguello, Liam J. Drew, Holly Moore, Amy B. MacDermott, Maria Karayiorgou, and Joseph A. Gogos

    PNAS May 13, 2008 105 (19) 7076-7081; https://doi.org/10.1073/pnas.0802615105

• Pharmacology

  • Open Access

    A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

    R. Scott Pearsall, Ernesto Canalis, Milton Cornwall-Brady, Kathryn W. Underwood, Brendan Haigis, Jeffrey Ucran, Ravindra Kumar, Eileen Pobre, Asya Grinberg, Eric D. Werner, Vaida Glatt, Lisa Stadmeyer, Deanna Smith, Jasbir Seehra, and Mary L. Bouxsein

    PNAS May 13, 2008 105 (19) 7082-7087; https://doi.org/10.1073/pnas.0711263105

• Physiology

  • Open Access

    Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila

    Julien Muffat, David W. Walker, and Seymour Benzer

    PNAS May 13, 2008 105 (19) 7088-7093; https://doi.org/10.1073/pnas.0800896105
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    Proteasomal adaptation to environmental stress links resistance to proteotoxicity with longevity in Caenorhabditis elegans

    Chi Yun, Ariel Stanhill, Yun Yang, Yuhong Zhang, Cole M. Haynes, Chong-Feng Xu, Thomas A. Neubert, Adam Mor, Mark R. Philips, and David Ron

    PNAS May 13, 2008 105 (19) 7094-7099; https://doi.org/10.1073/pnas.0707025105

• Plant Biology

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    COI1 is a critical component of a receptor for jasmonate and the bacterial virulence factor coronatine

    • From the Cover

    Leron Katsir, Anthony L. Schilmiller, Paul E. Staswick, Sheng Yang He, and Gregg A. Howe

    PNAS May 13, 2008 105 (19) 7100-7105; https://doi.org/10.1073/pnas.0802332105