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Research Article

Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration

Martin Balastik, Francesco Ferraguti, André Pires-da Silva, Tae Ho Lee, Gonzalo Alvarez-Bolado, Kun Ping Lu, and Peter Gruss
PNAS August 19, 2008 105 (33) 12016-12021; https://doi.org/10.1073/pnas.0802261105
Martin Balastik
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  • For correspondence: mbalasti@bidmc.harvard.edu peter.gruss@gv.mpg.de
Francesco Ferraguti
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André Pires-da Silva
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Tae Ho Lee
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Gonzalo Alvarez-Bolado
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Kun Ping Lu
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Peter Gruss
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  • For correspondence: mbalasti@bidmc.harvard.edu peter.gruss@gv.mpg.de
  1. Edited by Eric R. Kandel, Columbia University, New York, NY, and approved June 11, 2008 (received for review March 5, 2008)

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Article Information

vol. 105 no. 33 12016-12021
DOI: 
https://doi.org/10.1073/pnas.0802261105
PubMed: 
18687884

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue August 19, 2008.
  • Published first August 7, 2008.

Copyright & Usage: 
© 2008 by The National Academy of Sciences of the USA

Author Information

  1. Martin Balastik*,†,‡,
  2. Francesco Ferraguti§,¶,
  3. André Pires-da Silva*,‖,
  4. Tae Ho Lee†,
  5. Gonzalo Alvarez-Bolado*,
  6. Kun Ping Lu†, and
  7. Peter Gruss*,‡
  1. *Max Planck Institute of Biophysical Chemistry, 37077 Goettingen, Germany;
  2. §Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom;
  3. ¶Department of Pharmacology, Innsbruck Medical University, A-6020 Innsbruck, Austria;
  4. ‖Department of Biology, University of Texas, 501 South Nedderman, 337 Life Science, Arlington, TX 76010; and
  5. †Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115
  1. Edited by Eric R. Kandel, Columbia University, New York, NY, and approved June 11, 2008 (received for review March 5, 2008)

Footnotes

  • ‡To whom correspondence may be addressed. E-mail: mbalasti{at}bidmc.harvard.edu or peter.gruss{at}gv.mpg.de
  • Author contributions: M.B., G.A.-B., K.P.L., and P.G. designed research; M.B., F.F., A.P.-d.S., and T.H.L. performed research; T.H.L. contributed new reagents/analytic tools; M.B., F.F., G.A.-B., K.P.L., and P.G. analyzed data; and M.B. and F.F. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/cgi/content/full/0802261105/DCSupplemental.

  • © 2008 by The National Academy of Sciences of the USA

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    Frontiers in Physiology 2020 11
  • Exploring Neuronal Vulnerability to Head Trauma Using a Whole Exome Approach
    Omar Ibrahim, Heidi G. Sutherland, Neven Maksemous, Robert Smith, Larisa M. Haupt, Lyn R. Griffiths
    Journal of Neurotrauma 2020 37 17
  • Expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal NHL domain of human TRIM2
    Xiaotao Guan, Jun Li, Xingru Lü, Yu Dong, Weimin Chen, Xuemei Li
    Acta Crystallographica Section F Structural Biology Communications 2014 70 5
  • QuaDMutEx: quadratic driver mutation explorer
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    BMC Bioinformatics 2017 18 1
  • TRIM2 directly deubiquitinates and stabilizes Snail1 protein, mediating proliferation and metastasis of lung adenocarcinoma
    Zhaoxian Lin, Xing Lin, Lihuan Zhu, Jianyuan Huang, Yangyun Huang
    Cancer Cell International 2020 20 1
  • Biochemical characterization of TRIM72 E3 ligase and its interaction with the insulin receptor substrate 1
    Ishita Gupta, Shreya Dharadhar, Titia Sixma, Sameena Khan
    Biochemistry and Biophysics Reports 2020 21
  • Interplay of TRIM2 E3 Ubiquitin Ligase and ALIX/ESCRT Complex: Control of Developmental Plasticity During Early Neurogenesis
    Ashwin Lokapally, Herbert Neuhaus, Juliane Herfurth, Thomas Hollemann
    Cells 2020 9 7
  • Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis
    Qiqing Sun, Zeng Ye, Yi Qin, Guixiong Fan, Shunrong Ji, Qifeng Zhuo, Wenyan Xu, Wensheng Liu, Qiangsheng Hu, Mengqi Liu, Zheng Zhang, Xiaowu Xu, Xianjun Yu
    Oncogene 2020 39 42
  • Peripheral nerve disorders
    Kristl G. Claeys, Martin Lammens, Jan Senderek, Joachim Weis
    2014
  • Tumor suppressor p53 cross-talks with TRIM family proteins
    Juan Liu, Cen Zhang, Xue Wang, Wenwei Hu, Zhaohui Feng
    Genes & Diseases 2020

Article usage

Article usage: August 2008 to January 2021

AbstractFullPdf
Aug 2008364428242
Sep 200852147128
Oct 20082112974
Nov 20081813771
Dec 2008902031
Total 20084647161546
Jan 20091481939
Feb 20091022858
Mar 2009405329
Apr 200924309
May 2009212929
Jun 2009362713
Jul 2009264533
Aug 2009272519
Sep 2009212524
Oct 2009352312
Nov 2009333222
Dec 2009511923
Total 2009564355310
Jan 2010443220
Feb 2010262610
Mar 2010204216
Apr 2010191913
May 2010383111
Jun 2010353017
Jul 2010102713
Aug 2010722211
Sep 2010263418
Oct 2010222716
Nov 2010583317
Dec 201021243
Total 2010391347165
Jan 2011133510
Feb 2011262513
Mar 2011182421
Apr 201122208
May 2011213418
Jun 201162220
Jul 2011312014
Aug 2011241912
Sep 201119258
Oct 201123199
Nov 2011231815
Dec 2011331826
Total 2011259279174
Jan 2012312816
Feb 2012341410
Mar 2012352316
Apr 2012272313
May 2012401911
Jun 2012293219
Jul 2012342220
Aug 2012271816
Sep 2012292020
Oct 2012372021
Nov 2012221711
Dec 201218810
Total 2012363244183
Jan 201330186
Feb 2013302012
Mar 2013433723
Apr 2013252017
May 2013281211
Jun 2013312017
Jul 2013222913
Aug 201325139
Sep 2013221310
Oct 2013322410
Nov 201321158
Dec 20131792
Total 2013326230138
Jan 20142385
Feb 2014372010
Mar 201414126
Apr 2014473513
May 2014215817
Jun 2014214615
Jul 2014282310
Aug 201426344
Sep 201424458
Oct 201437287
Nov 2014272510
Dec 201417375
Total 2014322371110
Jan 2015211268
Feb 2015191634
Mar 20152210211
Apr 2015296719
May 201513717
Jun 2015345813
Jul 2015152217
Aug 201519194
Sep 201515176
Oct 2015131812
Nov 20152373
Dec 2015131313
Total 2015236683117
Jan 2016122210
Feb 201614148
Mar 201611157
Apr 2016191512
May 20169176
Jun 2016124010
Jul 2016273820
Aug 201612196
Sep 2016212620
Oct 2016231410
Nov 201616126
Dec 2016131210
Total 2016189244125
Jan 20171073
Feb 201712125
Mar 201716209
Apr 201716109
May 201742116
Jun 201782914
Jul 201714158
Aug 20178225
Sep 20176351
Oct 20176276
Nov 201771717
Dec 201710195
Total 201711723498
Jan 2018142711
Feb 201816295
Mar 2018374116
Apr 2018313312
May 201828318
Jun 201829364
Jul 201826289
Aug 201835359
Sep 201827306
Oct 20185274
Nov 20181329
Dec 20182355
Total 201825138498
Jan 201983710
Feb 2019104613
Mar 20192237
Apr 201935121
May 20197299
Jun 20192228
Jul 201972411
Aug 201952017
Sep 20194227
Oct 201944619
Nov 201984121
Dec 20195319
Total 201965392152
Jan 20205408
Feb 202002919
Mar 2020133625
Apr 20201286
May 202023414
Jun 202024316
Jul 202024313
Aug 20206307
Sep 20203324
Oct 202073512
Nov 2020104917
Dec 2020154312
Total 202066442153
Jan 20214239
Total 20214239
Total780043892378
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Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration
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Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration
Martin Balastik, Francesco Ferraguti, André Pires-da Silva, Tae Ho Lee, Gonzalo Alvarez-Bolado, Kun Ping Lu, Peter Gruss
Proceedings of the National Academy of Sciences Aug 2008, 105 (33) 12016-12021; DOI: 10.1073/pnas.0802261105

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Deficiency in ubiquitin ligase TRIM2 causes accumulation of neurofilament light chain and neurodegeneration
Martin Balastik, Francesco Ferraguti, André Pires-da Silva, Tae Ho Lee, Gonzalo Alvarez-Bolado, Kun Ping Lu, Peter Gruss
Proceedings of the National Academy of Sciences Aug 2008, 105 (33) 12016-12021; DOI: 10.1073/pnas.0802261105
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Proceedings of the National Academy of Sciences: 105 (33)
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