New Research In
Physical Sciences
Social Sciences
Featured Portals
Articles by Topic
Biological Sciences
Featured Portals
Articles by Topic
- Agricultural Sciences
- Anthropology
- Applied Biological Sciences
- Biochemistry
- Biophysics and Computational Biology
- Cell Biology
- Developmental Biology
- Ecology
- Environmental Sciences
- Evolution
- Genetics
- Immunology and Inflammation
- Medical Sciences
- Microbiology
- Neuroscience
- Pharmacology
- Physiology
- Plant Biology
- Population Biology
- Psychological and Cognitive Sciences
- Sustainability Science
- Systems Biology
Table of Contents
September 30, 2008; vol. 105 no. 39
This Week in PNAS
Letters (Online Only)
- You have accessContradictory saltation height measurements and unphysical assumptionsBruno Andreotti
- You have accessReply to Andreotti: Consistent saltation height measurements and physical assumptionsMurilo P. Almeida, Eric J. R. Parteli, José S. Andrade Jr., and Hans J. Herrmann
Perspective
- You have accessNavigating from hippocampus to parietal cortexJonathan R. Whitlock, Robert J. Sutherland, Menno P. Witter, May-Britt Moser, and Edvard I. Moser
Physical Sciences
Applied Physical Sciences
- You have accessExperimental characterization of shear transformation zones for plastic flow of bulk metallic glassesD. Pan, A. Inoue, T. Sakurai, and M. W. Chen
Chemistry
- You have accessFabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapyMinfang Zhang, Tatsuya Murakami, Kumiko Ajima, Kunihiro Tsuchida, Atula S. D. Sandanayaka, Osamu Ito, Sumio Iijima, and Masako Yudasaka
Physics
- Open AccessMelting of ice under pressureEric Schwegler, Manu Sharma, François Gygi, and Giulia Galli
- You have accessProbing atomic ordering and multiple twinning in metal nanocrystals through their vibrationsH. Portales, N. Goubet, L. Saviot, S. Adichtchev, D. B. Murray, A. Mermet, E. Duval, and M.-P. Pileni
Statistics
- Open AccessHigher criticism thresholding: Optimal feature selection when useful features are rare and weakDavid Donoho and Jiashun Jin
Social Sciences
Anthropology
- You have accessThe “fire stick farming” hypothesis: Australian Aboriginal foraging strategies, biodiversity, and anthropogenic fire mosaicsR. Bliege Bird, D. W. Bird, B. F. Codding, C. H. Parker, and J. H. Jones
See companion article:
- In This Issue- Sep 30, 2008
Biological Sciences
Agricultural Sciences
- Open AccessSequence and genetic map of Meloidogyne hapla: A compact nematode genome for plant parasitismCharles H. Opperman, David M. Bird, Valerie M. Williamson, Dan S. Rokhsar, Mark Burke, Jonathan Cohn, John Cromer, Steve Diener, Jim Gajan, Steve Graham, T. D. Houfek, Qingli Liu, Therese Mitros, Jennifer Schaff, Reenah Schaffer, Elizabeth Scholl, Bryon R. Sosinski, Varghese P. Thomas, and Eric Windham
See companion article:
- In This Issue- Sep 30, 2008
Applied Biological Sciences
- You have accessDirected evolution of a G protein-coupled receptor for expression, stability, and binding selectivity
- From the Cover
Casim A. Sarkar, Igor Dodevski, Manca Kenig, Stefan Dudli, Anja Mohr, Emmanuel Hermans, and Andreas PlückthunSee companion article:
- Open AccessEffective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomerBo Wu, Hong M. Moulton, Patrick L. Iversen, Jiangang Jiang, Juan Li, Jianbin Li, Christopher F. Spurney, Arpana Sali, Alfredo D. Guerron, Kanneboyina Nagaraju, Timothy Doran, Peijuan Lu, Xiao Xiao, and Qi Long Lu
Biochemistry
- You have accessRifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active centerAndrey Feklistov, Vladimir Mekler, Qiaorong Jiang, Lars F. Westblade, Herbert Irschik, Rolf Jansen, Arkady Mustaev, Seth A. Darst, and Richard H. Ebright
- Open AccessControl of feeding behavior in C. elegans by human G protein-coupled receptors permits screening for agonist-expressing bacteriaMichelle S. Teng, Paul Shadbolt, Andrew G. Fraser, Gert Jansen, and John McCafferty
- You have accessThe crystal structure of MexR from Pseudomonas aeruginosa in complex with its antirepressor ArmRMark S. Wilke, Markus Heller, A. Louise Creagh, Charles A. Haynes, Lawrence P. McIntosh, Keith Poole, and Natalie C. J. Strynadka
- You have accessThe Saccharomyces cerevisiae linker histone Hho1p is essential for chromatin compaction in stationary phase and is displaced by transcriptionGeorgia Schäfer, Christopher R. E. McEvoy, and Hugh-G. Patterton
- You have accessBacktracking on the folding landscape of the β-trefoil protein interleukin-1β?Dominique T. Capraro, Melinda Roy, José N. Onuchic, and Patricia A. Jennings
- You have accessDiscovery of posttranslational maturation by self-subunit swappingZhemin Zhou, Yoshiteru Hashimoto, Kentaro Shiraki, and Michihiko Kobayashi
Biophysics
- Open AccessModeling the chemotactic response of Escherichia coli to time-varying stimuliYuhai Tu, Thomas S. Shimizu, and Howard C. Berg
Cell Biology
- You have accessMitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytesIldikò Szabó, Jürgen Bock, Heike Grassmé, Matthias Soddemann, Barbara Wilker, Florian Lang, Mario Zoratti, and Erich Gulbins
- You have accessSustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancersNancy Dumont, Matthew B. Wilson, Yongping G. Crawford, Paul A. Reynolds, Mahvash Sigaroudinia, and Thea D. Tlsty
- You have accessRNAi screening for kinases and phosphatases identifies FoxO regulatorsJaakko Mattila, Jukka Kallijärvi, and Oscar Puig
- You have accessA search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequenceJoshua J. Forman, Aster Legesse-Miller, and Hilary A. Coller
- You have accessComputational prediction of RNA structural motifs involved in posttranscriptional regulatory processesMichal Rabani, Michael Kertesz, and Eran Segal
Developmental Biology
- You have accessThe mammary microenvironment alters the differentiation repertoire of neural stem cellsBrian W. Booth, David L. Mack, Andreas Androutsellis-Theotokis, Ronald D. G. McKay, Corinne A. Boulanger, and Gilbert H. Smith
See companion article:
- Reprogramming stem cells is a microenvironmental task- Oct 08, 2008
- You have accessBoundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
- From the Cover
Maria Willecke, Fisun Hamaratoglu, Leticia Sansores-Garcia, Chunyao Tao, and Georg Halder
Ecology
- You have accessSelf-made shelters protect spiders from predation
- From the Cover
Carryn Manicom, Lin Schwarzkopf, Ross A. Alford, and Thomas W. SchoenerSee companion article:
- Predators avoiding predation- Sep 23, 2008
- You have accessOpening the climate envelope reveals no macroscale associations with climate in European birdsColin M. Beale, Jack J. Lennon, and Alessandro Gimona
Evolution
- You have accessNewly discovered sister lineage sheds light on early ant evolutionChristian Rabeling, Jeremy M. Brown, and Manfred Verhaagh
- You have accessDrug interactions modulate the potential for evolution of resistanceJean-Baptiste Michel, Pamela J. Yeh, Remy Chait, Robert C. Moellering Jr., and Roy Kishony
See companion article:
- In This Issue- Sep 30, 2008
- You have accessPrevolutionary dynamics and the origin of evolutionMartin A. Nowak and Hisashi Ohtsuki
- You have accessAdaptive changes in the transcription factor HoxA-11 are essential for the evolution of pregnancy in mammalsVincent J. Lynch, Andrea Tanzer, Yajun Wang, Frederick C. Leung, Birgit Gellersen, Deena Emera, and Gunter P. Wagner
- You have accessEndosymbiont gene functions impaired and rescued by polymerase infidelity at poly(A) tractsIvica Tamas, Jennifer J. Wernegreen, Björn Nystedt, Seth N. Kauppinen, Alistair C. Darby, Laura Gomez-Valero, Daniel Lundin, Anthony M. Poole, and Siv G. E. Andersson
Genetics
- You have accessA common variant in the 3′UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorderB. S. Pickard, H. M. Knight, R. S. Hamilton, D. C. Soares, R. Walker, J. K. F. Boyd, J. Machell, A. Maclean, K. A. McGhee, A. Condie, D. J. Porteous, D. St. Clair, I. Davis, D. H. R. Blackwood, and W. J. Muir
- Open AccessAnalysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clockYuichi Kumaki, Maki Ukai-Tadenuma, Ken-ichiro D. Uno, Junko Nishio, Koh-hei Masumoto, Mamoru Nagano, Takashi Komori, Yasufumi Shigeyoshi, John B. Hogenesch, and Hiroki R. Ueda
- Open AccessSalmonella pathogenesis reveals that BMP signaling regulates blood cell homeostasis and immune responses in DrosophilaJoel L. Frandsen, Bronwyn Gunn, Selen Muratoglu, Nancy Fossett, and Stuart J. Newfeld
- You have accessDistinct size distribution of endogenous siRNAs in maize: Evidence from deep sequencing in the mop1-1 mutantKan Nobuta, Cheng Lu, Roli Shrivastava, Manoj Pillay, Emanuele De Paoli, Monica Accerbi, Mario Arteaga-Vazquez, Lyudmila Sidorenko, Dong-Hoon Jeong, Yang Yen, Pamela J. Green, Vicki L. Chandler, and Blake C. Meyers
- You have accesspiRNA-mediated nuclear accumulation of retrotransposon transcripts in the Drosophila female germlineSéverine Chambeyron, Anna Popkova, Geneviève Payen-Groschêne, Christine Brun, Dorsaf Laouini, Alain Pelisson, and Alain Bucheton
- You have accessThe stem rust resistance gene Rpg5 encodes a protein with nucleotide-binding-site, leucine-rich, and protein kinase domainsR. Brueggeman, A. Druka, J. Nirmala, T. Cavileer, T. Drader, N. Rostoks, A. Mirlohi, H. Bennypaul, U. Gill, D. Kudrna, C. Whitelaw, A. Kilian, F. Han, Y. Sun, K. Gill, B. Steffenson, and A. Kleinhofs
- Open AccessStra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in miceEricka L. Anderson, Andrew E. Baltus, Hermien L. Roepers-Gajadien, Terry J. Hassold, Dirk G. de Rooij, Ans M. M. van Pelt, and David C. Page
Immunology
- You have accessChemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysisThi Lien-Anh Nguyên, Hesham Abdelbary, Meztli Arguello, Caroline Breitbach, Simon Leveille, Jean-Simon Diallo, Amber Yasmeen, Tarek A. Bismar, David Kirn, Theresa Falls, Valerie E. Snoulten, Barbara C. Vanderhyden, Joel Werier, Harold Atkins, Markus J. V. Vähä-Koskela, David F. Stojdl, John C. Bell, and John Hiscott
- You have accessCTLA-4 blockade increases IFNγ-producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patientsChrysoula I. Liakou, Ashish Kamat, Derek Ng Tang, Hong Chen, Jingjing Sun, Patricia Troncoso, Christopher Logothetis, and Padmanee Sharma
- You have accessLocal BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritisQueenie Lai Kwan Lam, Otis King Hung Ko, Bo-Jian Zheng, and Liwei Lu
- You have accessRespiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cellsPablo A. González, Carolina E. Prado, Eduardo D. Leiva, Leandro J. Carreño, Susan M. Bueno, Claudia A. Riedel, and Alexis M. Kalergis
- You have accessIn vivo enzymatic modulation of IgG glycosylation inhibits autoimmune disease in an IgG subclass-dependent mannerHeike Albert, Mattias Collin, Diana Dudziak, Jeffrey V. Ravetch, and Falk Nimmerjahn
- You have accessDistinct sets of αβ TCRs confer similar recognition of tumor antigen NY-ESO-1157–165 by interacting with its central Met/Trp residuesLaurent Derré, Marc Bruyninx, Petra Baumgaertner, Mathias Ferber, Daphné Schmid, Antoine Leimgruber, Vincent Zoete, Pedro Romero, Olivier Michielin, Daniel E. Speiser, and Nathalie Rufer
- You have accessSelective expansion of a subset of exhausted CD8 T cells by αPD-L1 blockadeShawn D. Blackburn, Haina Shin, Gordon J. Freeman, and E. John Wherry
- You have accessNF-IL6 (C/EBPβ) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3GShigemi M. Kinoshita and Shizuka Taguchi
- You have accessInflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial triggerBen A. Croker, Brian R. Lawson, Sophie Rutschmann, Michael Berger, Celine Eidenschenk, Amanda L. Blasius, Eva Marie Y. Moresco, Sosathya Sovath, Louise Cengia, Leonard D. Shultz, Argyrios N. Theofilopoulos, Sven Pettersson, and Bruce Alan Beutler
Medical Sciences
- You have accessPreneoplastic lesion growth driven by the death of adjacent normal stem cellsDennis L. Chao, J. Thomas Eck, Douglas E. Brash, Carlo C. Maley, and E. Georg Luebeck
- You have accessIdentification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activityHans Petter Eikesdal, Hikaru Sugimoto, Gabriel Birrane, Yohei Maeshima, Vesselina G. Cooke, Mark Kieran, and Raghu Kalluri
- Open AccessAP4 encodes a c-MYC-inducible repressor of p21Peter Jung, Antje Menssen, Doris Mayr, and Heiko Hermeking
- You have accessPancreatic exocrine insufficiency in LXRβ−/− mice is associated with a reduction in aquaporin-1 expressionChiara Gabbi, Hyun-Jin Kim, Kjell Hultenby, Didier Bouton, Gudrun Toresson, Margaret Warner, and Jan-Åke Gustafsson
- You have accessOpposing functions of IKKβ during acute and chronic intestinal inflammationLars Eckmann, Tim Nebelsiek, Alexander A. Fingerle, Sara M. Dann, Jörg Mages, Roland Lang, Sylvie Robine, Martin F. Kagnoff, Roland M. Schmid, Michael Karin, Melek C. Arkan, and Florian R. Greten
- You have accessThe inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaMalin E. V. Johansson, Mia Phillipson, Joel Petersson, Anna Velcich, Lena Holm, and Gunnar C. Hansson
Microbiology
- You have accessA polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patientsChristopher D. Sibley, Michael D. Parkins, Harvey R. Rabin, Kangmin Duan, Jens C. Norgaard, and Michael G. Surette
- Open AccessThe convergence of carbohydrate active gene repertoires in human gut microbesCatherine A. Lozupone, Micah Hamady, Brandi L. Cantarel, Pedro M. Coutinho, Bernard Henrissat, Jeffrey I. Gordon, and Rob Knight
- Open AccessRole of selection in the emergence of lineages and the evolution of virulence in Neisseria meningitidisCaroline O. Buckee, Keith A. Jolley, Mario Recker, Bridget Penman, Paula Kriz, Sunetra Gupta, and Martin C. J. Maiden
- You have accessAn insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein ABrian L. Weiss, Yineng Wu, Jonathon J. Schwank, Nicholas S. Tolwinski, and Serap Aksoy
- You have accessThe genome of Cyanothece 51142, a unicellular diazotrophic cyanobacterium important in the marine nitrogen cycleEric A. Welsh, Michelle Liberton, Jana Stöckel, Thomas Loh, Thanura Elvitigala, Chunyan Wang, Aye Wollam, Robert S. Fulton, Sandra W. Clifton, Jon M. Jacobs, Rajeev Aurora, Bijoy K. Ghosh, Louis A. Sherman, Richard D. Smith, Richard K. Wilson, and Himadri B. Pakrasi
- You have accessA channel connecting the mother cell and forespore during bacterial endospore formationJeffrey Meisner, Xin Wang, Monica Serrano, Adriano O. Henriques, and Charles P. Moran Jr
Neuroscience
- You have accessAge-related changes in midbrain dopaminergic regulation of the human reward system
- From the Cover
Jean-Claude Dreher, Andreas Meyer-Lindenberg, Philip Kohn, and Karen Faith BermanSee companion article:
- In This Issue- Sep 30, 2008
- Is getting older all that rewarding?- Sep 23, 2008
- You have accessHuman gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kineticsArtur V. Cideciyan, Tomas S. Aleman, Sanford L. Boye, Sharon B. Schwartz, Shalesh Kaushal, Alejandro J. Roman, Ji-jing Pang, Alexander Sumaroka, Elizabeth A. M. Windsor, James M. Wilson, Terence R. Flotte, Gerald A. Fishman, Elise Heon, Edwin M. Stone, Barry J. Byrne, Samuel G. Jacobson, and William W. Hauswirth
See companion article:
- In This Issue- Sep 30, 2008
- You have accessAdenosine receptor antagonists alter the stability of human epileptic GABAA receptorsCristina Roseti, Katiuscia Martinello, Sergio Fucile, Vanessa Piccari, Addolorata Mascia, Giancarlo Di Gennaro, Pier Paolo Quarato, Mario Manfredi, Vincenzo Esposito, Gianpaolo Cantore, Antonella Arcella, Michele Simonato, Bertil B. Fredholm, Cristina Limatola, Ricardo Miledi, and Fabrizio Eusebi
- Open AccessMutational analysis of the neurexin/neuroligin complex reveals essential and regulatory componentsCarsten Reissner, Martin Klose, Richard Fairless, and Markus Missler
- You have accesscAMP/PKA signaling and RIM1α mediate presynaptic LTP in the lateral amygdalaElodie Fourcaudot, Frédéric Gambino, Yann Humeau, Guillaume Casassus, Hamdy Shaban, Bernard Poulain, and Andreas Lüthi
- You have accessMitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquatWon-Seok Choi, Shane E. Kruse, Richard D. Palmiter, and Zhengui Xia
- You have accessDisulfide locking a sodium channel voltage sensor reveals ion pair formation during activationPaul G. DeCaen, Vladimir Yarov-Yarovoy, Yong Zhao, Todd Scheuer, and William A. Catterall
- You have accessEstrogens directly potentiate neuronal L-type Ca2+ channelsSaumyendra N. Sarkar, Ren-Qi Huang, Shaun M. Logan, Kun Don Yi, Glenn H. Dillon, and James W. Simpkins
- You have accessThe BK-mediated fAHP is modulated by learning a hippocampus-dependent taskElizabeth A. Matthews, Aldis P. Weible, Samit Shah, and John F. Disterhoft
- You have accessSpontaneous neural activity during human slow wave sleepThien Thanh Dang-Vu, Manuel Schabus, Martin Desseilles, Geneviève Albouy, Mélanie Boly, Annabelle Darsaud, Steffen Gais, Géraldine Rauchs, Virginie Sterpenich, Gilles Vandewalle, Julie Carrier, Gustave Moonen, Evelyne Balteau, Christian Degueldre, André Luxen, Christophe Phillips, and Pierre Maquet
Pharmacology
- You have accessFabrication of ZnPc/protein nanohorns for double photodynamic and hyperthermic cancer phototherapyMinfang Zhang, Tatsuya Murakami, Kumiko Ajima, Kunihiro Tsuchida, Atula S. D. Sandanayaka, Osamu Ito, Sumio Iijima, and Masako Yudasaka
- You have accessSuperoxide anions regulate TORC1 and its ability to bind Fpr1:rapamycin complexTaavi K. Neklesa and Ronald W. Davis
Physiology
- Open AccessPhysiological significance of a peripheral tissue circadian clock
- From the Cover
Katja A. Lamia, Kai-Florian Storch, and Charles J. WeitzSee companion article:
Plant Biology
- You have accessTetrapyrrole profiling in Arabidopsis seedlings reveals that retrograde plastid nuclear signaling is not due to Mg-protoporphyrin IX accumulationMichael Moulin, Alex C. McCormac, Matthew J. Terry, and Alison G. Smith
- You have accessThe steady-state level of Mg-protoporphyrin IX is not a determinant of plastid-to-nucleus signaling in ArabidopsisNobuyoshi Mochizuki, Ryouichi Tanaka, Ayumi Tanaka, Tatsuru Masuda, and Akira Nagatani
- You have accessNew auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone deliverySigal Savaldi-Goldstein, Thomas J. Baiga, Florence Pojer, Tsegeye Dabi, Cristina Butterfield, Geraint Parry, Aaron Santner, Nihal Dharmasiri, Yi Tao, Mark Estelle, Joseph P. Noel, and Joanne Chory
- You have accesssparse inflorescence1 encodes a monocot-specific YUCCA-like gene required for vegetative and reproductive development in maizeAndrea Gallavotti, Solmaz Barazesh, Simon Malcomber, Darren Hall, David Jackson, Robert J. Schmidt, and Paula McSteen
- You have accessEvolutionary linkage between eukaryotic cytokinesis and chloroplast division by dynamin proteinsShin-ya Miyagishima, Hidekazu Kuwayama, Hideko Urushihara, and Hiromitsu Nakanishi
- You have accessNon-cell-autonomous control of vascular stem cell fate by a CLE peptide/receptor systemYuki Hirakawa, Hidefumi Shinohara, Yuki Kondo, Asuka Inoue, Ikuko Nakanomyo, Mari Ogawa, Shinichiro Sawa, Kyoko Ohashi-Ito, Yoshikatsu Matsubayashi, and Hiroo Fukuda
Psychology
- You have accessUnconscious processing dissociates along categorical linesJorge Almeida, Bradford Z. Mahon, Ken Nakayama, and Alfonso Caramazza
Commentaries
See companion article:
See companion article:
See companion article:
See companion article: