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Research Article

Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response

John Stagg, Janelle Sharkey, Sandra Pommey, Richard Young, Kazuyoshi Takeda, Hideo Yagita, Ricky W. Johnstone, and Mark J. Smyth
PNAS October 21, 2008 105 (42) 16254-16259; https://doi.org/10.1073/pnas.0806849105
John Stagg
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Janelle Sharkey
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Sandra Pommey
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Richard Young
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Kazuyoshi Takeda
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Hideo Yagita
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  • For correspondence: mark.smyth@petermac.org
  1. Edited by Jeffrey Ravetch, The Rockefeller University, New York, NY, and approved August 25, 2008 (received for review July 15, 2008)

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Article Information

vol. 105 no. 42 16254-16259
DOI: 
https://doi.org/10.1073/pnas.0806849105
PubMed: 
18838682

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue October 21, 2008.
  • Published first October 6, 2008.

Copyright & Usage: 
© 2008 by The National Academy of Sciences of the USA

Author Information

  1. John Stagg*,
  2. Janelle Sharkey*,
  3. Sandra Pommey†,‡,
  4. Richard Young*,
  5. Kazuyoshi Takeda§,
  6. Hideo Yagita§,
  7. Ricky W. Johnstone*, and
  8. Mark J. Smyth*,¶
  1. *Cancer Immunology Program, Sir Donald and Lady Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne 3002, Australia;
  2. †Immunology Research Centre, St. Vincent's Hospital Melbourne, Melbourne 3065, Australia;
  3. ‡Department of Medicine, University of Melbourne, Melbourne 3010, Australia; and
  4. §Department of Immunology, Juntendo University School of Medicine, Tokyo 113-8421, Japan
  1. Edited by Jeffrey Ravetch, The Rockefeller University, New York, NY, and approved August 25, 2008 (received for review July 15, 2008)

Footnotes

  • ¶To whom correspondence should be addressed. E-mail: mark.smyth{at}petermac.org
  • Author contributions: J. Stagg, K.T., R.W.J., and M.J.S. designed research; J. Stagg, J. Sharkey, S.P., and R.Y. performed research; J. Stagg, K.T., H.Y., R.W.J., and M.J.S. analyzed data; and J. Stagg, H.Y., R.W.J., and M.J.S. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/cgi/content/full/0806849105/DCSupplemental.

  • © 2008 by The National Academy of Sciences of the USA

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Oct 2008432356392
Nov 200869038146
Dec 20082642381
Total 20085277117619
Jan 20092032666
Feb 20091571942
Mar 2009805444
Apr 2009545048
May 2009323325
Jun 2009423017
Jul 2009413213
Aug 2009373029
Sep 2009303424
Oct 2009452018
Nov 2009541824
Dec 2009692536
Total 2009844371386
Jan 201050179
Feb 2010541922
Mar 2010362623
Apr 2010533351
May 2010242115
Jun 2010521718
Jul 2010341812
Aug 2010841511
Sep 201018199
Oct 201019138
Nov 2010141615
Dec 2010191510
Total 2010457229203
Jan 2011131316
Feb 2011111111
Mar 2011151526
Apr 2011181520
May 201118814
Jun 201118913
Jul 201127923
Aug 2011241313
Sep 2011331810
Oct 201116109
Nov 201118137
Dec 201119148
Total 2011230148170
Jan 2012181214
Feb 20121899
Mar 201216144
Apr 201220115
May 2012201714
Jun 201234913
Jul 201217716
Aug 20122073
Sep 20121375
Oct 201218117
Nov 201224119
Dec 201212125
Total 2012230127104
Jan 20132367
Feb 201317116
Mar 20131875
Apr 20133378
May 2013111010
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Jul 201314168
Aug 201314106
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Oct 2013141814
Nov 20131239
Dec 201320137
Total 201320612398
Jan 201435814
Feb 20141458
Mar 201423126
Apr 2014201110
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Total 201424315399
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Mar 2015181812
Apr 201521119
May 2015857
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Jul 2015455
Aug 2015977
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Oct 20152157
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Total 20151618589
Jan 20168613
Feb 20161049
Mar 201620513
Apr 201611103
May 201622114
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Jul 20161576
Aug 20161044
Sep 20165910
Oct 20161735
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Dec 20161067
Total 20161568382
Jan 2017843
Feb 20171576
Mar 201721105
Apr 20171034
May 2017786
Jun 2017732
Jul 2017946
Aug 201713103
Sep 20171255
Oct 2017967
Nov 2017855
Dec 2017854
Total 20171277056
Jan 20187112
Feb 201813123
Mar 20189128
Apr 201816195
May 201819239
Jun 201811122
Jul 201814163
Aug 20187111
Sep 201813141
Oct 20183121
Nov 20180193
Dec 20180202
Total 201811218140
Jan 2019092
Feb 20190114
Mar 20193107
Apr 20190198
May 20191164
Jun 2019063
Jul 20190159
Aug 20190169
Sep 20191127
Oct 20192207
Nov 20190157
Dec 20190155
Total 2019716472
Jan 20204187
Feb 2020182
Mar 20201115
Apr 2020151
May 20200124
Jun 2020262
Jul 2020062
Aug 2020034
Sep 20203166
Oct 202061314
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Dec 20205136
Total 20203013061
Jan 2021188
Total 2021188
Total808119892087
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Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response
John Stagg, Janelle Sharkey, Sandra Pommey, Richard Young, Kazuyoshi Takeda, Hideo Yagita, Ricky W. Johnstone, Mark J. Smyth
Proceedings of the National Academy of Sciences Oct 2008, 105 (42) 16254-16259; DOI: 10.1073/pnas.0806849105

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Antibodies targeted to TRAIL receptor-2 and ErbB-2 synergize in vivo and induce an antitumor immune response
John Stagg, Janelle Sharkey, Sandra Pommey, Richard Young, Kazuyoshi Takeda, Hideo Yagita, Ricky W. Johnstone, Mark J. Smyth
Proceedings of the National Academy of Sciences Oct 2008, 105 (42) 16254-16259; DOI: 10.1073/pnas.0806849105
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