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Introductory Perspective

The Sackler Colloquium on promises and perils in nanotechnology for medicine

Robert H. Austin and Shuang-fang Lim
PNAS November 11, 2008 105 (45) 17217-17221; https://doi.org/10.1073/pnas.0709499105
Robert H. Austin
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Shuang-fang Lim
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  • For correspondence: austin@princeton.edu
  1. Edited by Nicholas J. Turro, Columbia University, New York, NY, and approved September 23, 2008 (received for review September 6, 2008)

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    SEM picture of asbestos fibers (6).

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    Fig. 2.

    Crystal structures of the 2 forms of titanium dioxide. (A) Thermodynamic stable bulk rutile unit cell of titanium dioxide. (B) Anaphase unit cell, which in nanocrystals and under certain solvent conditions can be the stable phase.

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    Fig. 3.

    HRTEM image of upconverting nanophosphor from the 2-EHA based precursor, showing selected nanoparticle and its corresponding Fourier transform diffraction pattern. The nanophosphor size and distribution were analyzed by a Philips CM200 FEG-TEM. Nanophosphors for electron microscopy were collected during spray pyrolysis directly onto TEM Cu-grids coated with holey carbon film.

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    Fig. 4.

    Analysis of nanoparticle sizes. (A) Particle size distribution of nanophosphors obtained from the 2-EHA based precursor. (B) Volume distribution of sub-10-nm nanophosphors suspended in THF, with and without SDS. Particle size distributions in suspension were measured by using dynamic light scattering on a Malvern Zetasizer Nano-ZS (Malvern Instruments).

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    Fig. 5.

    The XRD spectrum showing sub-10- (broken line) and 40-nm particles (solid line).

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    Fig. 6.

    Volume distribution of PEG-silanized nanophosphors suspended in ultrapure water showing pH dependence. Particle size distributions in suspension were measured by using dynamic light scattering on a Malvern Zetasizer Nano-ZS (Malvern Instruments).

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    Fig. 7.

    Images of nanoparticles with C. elegans. (A) False-color 2-photon images of C. elegans at 980-nm excitation with green representing the bright field and red for the PEG-silanized sub-10-nm nanophosphor emission at 60× magnification. (B) Combined image of 40-nm nanophosphor-fed worm with gray representing the SEM image, and red representing the cathode luminescence (CL) image. The CL image was obtained by monitoring the total light intensity from the sample by using a photomultiplier tube, without any color filtering. The sample was tilted at a 45° angle to the incoming beam, leading to some topography-induced contrast in the CL image.

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The Sackler Colloquium on promises and perils in nanotechnology for medicine
Robert H. Austin, Shuang-fang Lim
Proceedings of the National Academy of Sciences Nov 2008, 105 (45) 17217-17221; DOI: 10.1073/pnas.0709499105

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The Sackler Colloquium on promises and perils in nanotechnology for medicine
Robert H. Austin, Shuang-fang Lim
Proceedings of the National Academy of Sciences Nov 2008, 105 (45) 17217-17221; DOI: 10.1073/pnas.0709499105
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Proceedings of the National Academy of Sciences: 105 (45)
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    • Our Own Work in New Nanomaterials: Upconversion Phosphors (UCPs)
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