Table of Contents

Biological Sciences

• Applied Biological Sciences

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    A biodegradable and biocompatible gecko-inspired tissue adhesive

    • From the Cover

    Alborz Mahdavi, Lino Ferreira, Cathryn Sundback, Jason W. Nichol, Edwin P. Chan, David J. D. Carter, Chris J. Bettinger, Siamrut Patanavanich, Loice Chignozha, Eli Ben-Joseph, Alex Galakatos, Howard Pryor, Irina Pomerantseva, Peter T. Masiakos, William Faquin, Andreas Zumbuehl, Seungpyo Hong, Jeffrey Borenstein, Joseph Vacanti, Robert Langer, and Jeffrey M. Karp

    PNAS February 19, 2008 105 (7) 2307-2312; https://doi.org/10.1073/pnas.0712117105
  • Open Access

    The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8

    Wolf Wrasidlo, Ainhoa Mielgo, Vicente A. Torres, Simone Barbero, Konstantin Stoletov, Takashi L. Suyama, Richard L. Klemke, William H. Gerwick, Dennis A. Carson, and Dwayne G. Stupack

    PNAS February 19, 2008 105 (7) 2313-2318; https://doi.org/10.1073/pnas.0712198105
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    Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains

    Daniel Klein-Marcuschamer and Gregory Stephanopoulos

    PNAS February 19, 2008 105 (7) 2319-2324; https://doi.org/10.1073/pnas.0712177105

• Biochemistry

  • Open Access

    Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

    • From the Cover

    Kevin J. Pearson, Kaitlyn N. Lewis, Nathan L. Price, Joy W. Chang, Evelyn Perez, Maria Victoria Cascajo, Kellie L. Tamashiro, Suresh Poosala, Anna Csiszar, Zoltan Ungvari, Thomas W. Kensler, Masayuki Yamamoto, Josephine M. Egan, Dan L. Longo, Donald K. Ingram, Placido Navas, and Rafael de Cabo

    PNAS February 19, 2008 105 (7) 2325-2330; https://doi.org/10.1073/pnas.0712162105
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    Crystal structure of tetrameric form of human lysyl-tRNA synthetase: Implications for multisynthetase complex formation

    Min Guo, Michael Ignatov, Karin Musier-Forsyth, Paul Schimmel, and Xiang-Lei Yang

    PNAS February 19, 2008 105 (7) 2331-2336; https://doi.org/10.1073/pnas.0712072105
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    Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRn

    Adam R. Mezo, Kevin A. McDonnell, Cristina A. Tan Hehir, Susan C. Low, Vito J. Palombella, James M. Stattel, George D. Kamphaus, Cara Fraley, Yixia Zhang, Jennifer A. Dumont, and Alan J. Bitonti

    PNAS February 19, 2008 105 (7) 2337-2342; https://doi.org/10.1073/pnas.0708960105
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    Transitive homology-guided structural studies lead to discovery of Cro proteins with 40% sequence identity but different folds

    Christian G. Roessler, Branwen M. Hall, William J. Anderson, Wendy M. Ingram, Sue A. Roberts, William R. Montfort, and Matthew H. J. Cordes

    PNAS February 19, 2008 105 (7) 2343-2348; https://doi.org/10.1073/pnas.0711589105
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    Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis

    Rashna Bhandari, Krishna R. Juluri, Adam C. Resnick, and Solomon H. Snyder

    PNAS February 19, 2008 105 (7) 2349-2353; https://doi.org/10.1073/pnas.0712227105
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    Rapid selection of accessible and cleavable sites in RNA by Escherichia coli RNase P and random external guide sequences

    Eirik W. Lundblad, Gaoping Xiao, Jae-hyeong Ko, and Sidney Altman

    PNAS February 19, 2008 105 (7) 2354-2357; https://doi.org/10.1073/pnas.0711977105
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    Cell growth, global phosphotyrosine elevation, and c-Met phosphorylation through Src family kinases in colorectal cancer cells

    Muhammad Emaduddin, David C. Bicknell, Walter F. Bodmer, and Stephan M. Feller

    PNAS February 19, 2008 105 (7) 2358-2362; https://doi.org/10.1073/pnas.0712176105
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    The same mutation in Gsα and transducin α reveals behavioral differences between these highly homologous G protein α-subunits

    Adolfo R. Zurita and Lutz Birnbaumer

    PNAS February 19, 2008 105 (7) 2363-2368; https://doi.org/10.1073/pnas.0712261105

• Biophysics

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    An experimental survey of the transition between two-state and downhill protein folding scenarios

    Feng Liu, Deguo Du, Amelia A. Fuller, Jennifer E. Davoren, Peter Wipf, Jeffery W. Kelly, and Martin Gruebele

    PNAS February 19, 2008 105 (7) 2369-2374; https://doi.org/10.1073/pnas.0711908105
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    Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus

    A. K. Överby, R. F. Pettersson, K. Grünewald, and J. T. Huiskonen

    PNAS February 19, 2008 105 (7) 2375-2379; https://doi.org/10.1073/pnas.0708738105
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    SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes

    David Tareste, Jingshi Shen, Thomas J. Melia, and James E. Rothman

    PNAS February 19, 2008 105 (7) 2380-2385; https://doi.org/10.1073/pnas.0712125105
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    Three-dimensional structure of vertebrate cardiac muscle myosin filaments

    Maria E. Zoghbi, John L. Woodhead, Richard L. Moss, and Roger Craig

    PNAS February 19, 2008 105 (7) 2386-2390; https://doi.org/10.1073/pnas.0708912105
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    Structural and biochemical insights into the dicing mechanism of mouse Dicer: A conserved lysine is critical for dsRNA cleavage

    Zhihua Du, John K. Lee, Richard Tjhen, Robert M. Stroud, and Thomas L. James

    PNAS February 19, 2008 105 (7) 2391-2396; https://doi.org/10.1073/pnas.0711506105
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    Cooperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues

    Wookyung Yu, Kwanghoon Chung, Mookyung Cheon, Muyoung Heo, Kyou-Hoon Han, Sihyun Ham, and Iksoo Chang

    PNAS February 19, 2008 105 (7) 2397-2402; https://doi.org/10.1073/pnas.0708480105
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    Amyloid of Rnq1p, the basis of the [PIN⁺] prion, has a parallel in-register β-sheet structure

    Reed B. Wickner, Fred Dyda, and Robert Tycko

    PNAS February 19, 2008 105 (7) 2403-2408; https://doi.org/10.1073/pnas.0712032105
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    Mechanisms of prion protein assembly into amyloid

    Jan Stöhr, Nicole Weinmann, Holger Wille, Tina Kaimann, Luitgard Nagel-Steger, Eva Birkmann, Giannantonio Panza, Stanley B. Prusiner, Manfred Eigen, and Detlev Riesner

    PNAS February 19, 2008 105 (7) 2409-2414; https://doi.org/10.1073/pnas.0712036105

• Cell Biology

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    A chemical method for fast and sensitive detection of DNA synthesis in vivo

    Adrian Salic and Timothy J. Mitchison

    PNAS February 19, 2008 105 (7) 2415-2420; https://doi.org/10.1073/pnas.0712168105
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    The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis

    Zhao Xu, Songtao Yu, Chung-Hsin Hsu, Jun Eguchi, and Evan D. Rosen

    PNAS February 19, 2008 105 (7) 2421-2426; https://doi.org/10.1073/pnas.0707082105
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    Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca²⁺ release and apoptosis

    Tania Szado, Veerle Vanderheyden, Jan B. Parys, Humbert De Smedt, Katja Rietdorf, Larissa Kotelevets, Eric Chastre, Farid Khan, Ulf Landegren, Ola Söderberg, Martin D. Bootman, and H. Llewelyn Roderick

    PNAS February 19, 2008 105 (7) 2427-2432; https://doi.org/10.1073/pnas.0711324105
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    Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERβ-null mutant

    Maria Cristina Antal, Andrée Krust, Pierre Chambon, and Manuel Mark

    PNAS February 19, 2008 105 (7) 2433-2438; https://doi.org/10.1073/pnas.0712029105
  • Open Access

    Anthrax lethal toxin induces cell death-independent permeability in zebrafish vasculature

    Robert E. Bolcome III, Sarah E. Sullivan, René Zeller, Adam P. Barker, R. John Collier, and Joanne Chan

    PNAS February 19, 2008 105 (7) 2439-2444; https://doi.org/10.1073/pnas.0712195105
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    Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

    Yi Tang, Krit Kitisin, Wilma Jogunoori, Cuiling Li, Chu-Xia Deng, Susette C. Mueller, Habtom W. Ressom, Asif Rashid, Aiwu Ruth He, Jonathan S. Mendelson, John M. Jessup, Kirti Shetty, Michael Zasloff, Bibhuti Mishra, E. P. Reddy, Lynt Johnson, and Lopa Mishra

    PNAS February 19, 2008 105 (7) 2445-2450; https://doi.org/10.1073/pnas.0705395105
  • Open Access

    Dissection of the insulin signaling pathway via quantitative phosphoproteomics

    Marcus Krüger, Irina Kratchmarova, Blagoy Blagoev, Yu-Hua Tseng, C. Ronald Kahn, and Matthias Mann

    PNAS February 19, 2008 105 (7) 2451-2456; https://doi.org/10.1073/pnas.0711713105
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    A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

    Kumiko Samejima, Hiromi Ogawa, Carol A. Cooke, Damien Hudson, Fiona MacIsaac, Susana A. Ribeiro, Paola Vagnarelli, Stefano Cardinale, Alastair Kerr, Fan Lai, Sandrine Ruchaud, Zuojun Yue, and William C. Earnshaw

    PNAS February 19, 2008 105 (7) 2457-2462; https://doi.org/10.1073/pnas.0712083105
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    Four distinct pathways of hemoglobin uptake in the malaria parasite Plasmodium falciparum

    David A. Elliott, Michael T. McIntosh, H. Dean Hosgood III, Shuo Chen, Gina Zhang, Pavlina Baevova, and Keith A. Joiner

    PNAS February 19, 2008 105 (7) 2463-2468; https://doi.org/10.1073/pnas.0711067105

• Developmental Biology

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    A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis

    Shin Yoshimoto, Ema Okada, Hirohito Umemoto, Kei Tamura, Yoshinobu Uno, Chizuko Nishida-Umehara, Yoichi Matsuda, Nobuhiko Takamatsu, Tadayoshi Shiba, and Michihiko Ito

    PNAS February 19, 2008 105 (7) 2469-2474; https://doi.org/10.1073/pnas.0712244105
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    Cellular components and signals required for the cardiac outflow tract assembly in Drosophila

    Monika Zmojdzian, Jean Philippe Da Ponte, and Krzysztof Jagla

    PNAS February 19, 2008 105 (7) 2475-2480; https://doi.org/10.1073/pnas.0706402105
  • Open Access

    Atbf1 is required for the Pit1 gene early activation

    Yingchuan Qi, Jeffrey A. Ranish, Xiaoyan Zhu, Anna Krones, Jie Zhang, Ruedi Aebersold, David W. Rose, Michael G. Rosenfeld, and Catherine Carrière

    PNAS February 19, 2008 105 (7) 2481-2486; https://doi.org/10.1073/pnas.0712196105
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    IKKα is a critical coregulator of a Smad4-independent TGFβ-Smad2/3 signaling pathway that controls keratinocyte differentiation

    Pascal Descargues, Alok K. Sil, Yuji Sano, Olexandr Korchynskyi, Gangwen Han, Philip Owens, Xiao-Jing Wang, and Michael Karin

    PNAS February 19, 2008 105 (7) 2487-2492; https://doi.org/10.1073/pnas.0712044105

• Ecology

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    King penguin population threatened by Southern Ocean warming

    Céline Le Bohec, Joël M. Durant, Michel Gauthier-Clerc, Nils C. Stenseth, Young-Hyang Park, Roger Pradel, David Grémillet, Jean-Paul Gendner, and Yvon Le Maho

    PNAS February 19, 2008 105 (7) 2493-2497; https://doi.org/10.1073/pnas.0712031105
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    Lifespan and reproduction in Drosophila: New insights from nutritional geometry

    Kwang Pum Lee, Stephen J. Simpson, Fiona J. Clissold, Robert Brooks, J. William O. Ballard, Phil W. Taylor, Nazaneen Soran, and David Raubenheimer

    PNAS February 19, 2008 105 (7) 2498-2503; https://doi.org/10.1073/pnas.0710787105

• Environmental Sciences

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    Evidence for a fundamental and pervasive shift away from nature-based recreation

    Oliver R. W. Pergams and Patricia A. Zaradic

    PNAS February 19, 2008 105 (7) 2295-2300; https://doi.org/10.1073/pnas.0709893105

• Evolution

  • Open Access

    Identifying the fundamental units of bacterial diversity: A paradigm shift to incorporate ecology into bacterial systematics

    Alexander Koeppel, Elizabeth B. Perry, Johannes Sikorski, Danny Krizanc, Andrew Warner, David M. Ward, Alejandro P. Rooney, Evelyne Brambilla, Nora Connor, Rodney M. Ratcliff, Eviatar Nevo, and Frederick M. Cohan

    PNAS February 19, 2008 105 (7) 2504-2509; https://doi.org/10.1073/pnas.0712205105
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    Genome evolution in cyanobacteria: The stable core and the variable shell

    Tuo Shi and Paul G. Falkowski

    PNAS February 19, 2008 105 (7) 2510-2515; https://doi.org/10.1073/pnas.0711165105
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    Distribution of cytotoxic and DNA ADP-ribosylating activity in crude extracts from butterflies among the family Pieridae

    Yasuko Matsumoto, Tsuyoshi Nakano, Masafumi Yamamoto, Yuko Matsushima-Hibiya, Ken-Ichi Odagiri, Osamu Yata, Kotaro Koyama, Takashi Sugimura, and Keiji Wakabayashi

    PNAS February 19, 2008 105 (7) 2516-2520; https://doi.org/10.1073/pnas.0712221105

• Genetics

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    Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

    Chandrahas Koumar Ratnacaram, Marius Teletin, Ming Jiang, Xiangjun Meng, Pierre Chambon, and Daniel Metzger

    PNAS February 19, 2008 105 (7) 2521-2526; https://doi.org/10.1073/pnas.0712021105
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    Discovering gapped binding sites of yeast transcription factors

    Chien-Yu Chen, Huai-Kuang Tsai, Chen-Ming Hsu, Mei-Ju May Chen, Hao-Geng Hung, Grace Tzu-Wei Huang, and Wen-Hsiung Li

    PNAS February 19, 2008 105 (7) 2527-2532; https://doi.org/10.1073/pnas.0712188105
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    Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins

    Antonio Starcevic, Shamima Akthar, Walter C. Dunlap, J. Malcolm Shick, Daslav Hranueli, John Cullum, and Paul F. Long

    PNAS February 19, 2008 105 (7) 2533-2537; https://doi.org/10.1073/pnas.0707388105
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    Mutations in FN1 cause glomerulopathy with fibronectin deposits

    Federica Castelletti, Roberta Donadelli, Federica Banterla, Friedhelm Hildebrandt, Peter F. Zipfel, Elena Bresin, Edgar Otto, Christine Skerka, Alessandra Renieri, Marta Todeschini, Jessica Caprioli, Rosa Maria Caruso, Rosangela Artuso, Giuseppe Remuzzi, and Marina Noris

    PNAS February 19, 2008 105 (7) 2538-2543; https://doi.org/10.1073/pnas.0707730105
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    A multimetric approach to analysis of genome-wide association by single markers and composite likelihood

    Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kääb, Andrew R. Collins, Thomas Meitinger, and Newton Morton

    PNAS February 19, 2008 105 (7) 2592-2597; https://doi.org/10.1073/pnas.0711903105

• Immunology

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    ATF3 regulates MCMV infection in mice by modulating IFN-γ expression in natural killer cells

    Carrie M. Rosenberger, April E. Clark, Piper M. Treuting, Carrie D. Johnson, and Alan Aderem

    PNAS February 19, 2008 105 (7) 2544-2549; https://doi.org/10.1073/pnas.0712182105
  • Open Access

    Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-β-dependent mechanism

    Michael Esquerré, Baptiste Tauzin, Martine Guiraud, Sabina Müller, Abdelhadi Saoudi, and Salvatore Valitutti

    PNAS February 19, 2008 105 (7) 2550-2555; https://doi.org/10.1073/pnas.0708350105
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    A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis

    Arnaud Couzinet, Kaoru Tamura, Hui-min Chen, Keishiro Nishimura, ZhiChao Wang, Yasuyuki Morishita, Kazuyoshi Takeda, Hideo Yagita, Hideyuki Yanai, Tadatsugu Taniguchi, and Tomohiko Tamura

    PNAS February 19, 2008 105 (7) 2556-2561; https://doi.org/10.1073/pnas.0712295105
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    Pseudomonas aeruginosa activates caspase 1 through Ipaf

    Edward A. Miao, Robert K. Ernst, Monica Dors, Dat P. Mao, and Alan Aderem

    PNAS February 19, 2008 105 (7) 2562-2567; https://doi.org/10.1073/pnas.0712183105
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    WIP is essential for lytic granule polarization and NK cell cytotoxicity

    Konrad Krzewski, Xi Chen, and Jack L. Strominger

    PNAS February 19, 2008 105 (7) 2568-2573; https://doi.org/10.1073/pnas.0711593105
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    The microbial mimic poly IC induces durable and protective CD4⁺ T cell immunity together with a dendritic cell targeted vaccine

    Christine Trumpfheller, Marina Caskey, Godwin Nchinda, Maria Paula Longhi, Olga Mizenina, Yaoxing Huang, Sarah J. Schlesinger, Marco Colonna, and Ralph M. Steinman

    PNAS February 19, 2008 105 (7) 2574-2579; https://doi.org/10.1073/pnas.0711976105
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    Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

    Niti Puri and Paul A. Roche

    PNAS February 19, 2008 105 (7) 2580-2585; https://doi.org/10.1073/pnas.0707854105

• Medical Sciences

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    Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST)

    Wen Ling, Ravinder R. Regatte, Gil Navon, and Alexej Jerschow

    PNAS February 19, 2008 105 (7) 2266-2270; https://doi.org/10.1073/pnas.0707666105
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    Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers

    • From the Cover

    Frank Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang, Aleksandar F. Radovic-Moreno, Robert Langer, and Omid C. Farokhzad

    PNAS February 19, 2008 105 (7) 2586-2591; https://doi.org/10.1073/pnas.0711714105
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    A multimetric approach to analysis of genome-wide association by single markers and composite likelihood

    Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kääb, Andrew R. Collins, Thomas Meitinger, and Newton Morton

    PNAS February 19, 2008 105 (7) 2592-2597; https://doi.org/10.1073/pnas.0711903105
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    Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1α

    Mihaela Ignat, Marius Teletin, Johan Tisserand, Konstantin Khetchoumian, Christine Dennefeld, Pierre Chambon, Régine Losson, and Manuel Mark

    PNAS February 19, 2008 105 (7) 2598-2603; https://doi.org/10.1073/pnas.0712030105
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    The genome landscape of ERα- and ERβ-binding DNA regions

    Yawen Liu, Hui Gao, Troels Torben Marstrand, Anders Ström, Eivind Valen, Albin Sandelin, Jan-Åke Gustafsson, and Karin Dahlman-Wright

    PNAS February 19, 2008 105 (7) 2604-2609; https://doi.org/10.1073/pnas.0712085105
  • Open Access

    Heart failure drug digitoxin induces calcium uptake into cells by forming transmembrane calcium channels

    Nelson Arispe, Juan Carlos Diaz, Olga Simakova, and Harvey B. Pollard

    PNAS February 19, 2008 105 (7) 2610-2615; https://doi.org/10.1073/pnas.0712270105
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    Chemically modified β-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII

    Jeffrey H. Grubb, Carole Vogler, Beth Levy, Nancy Galvin, Yun Tan, and William S. Sly

    PNAS February 19, 2008 105 (7) 2616-2621; https://doi.org/10.1073/pnas.0712147105
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    PTEN regulates p300-dependent hypoxia-inducible factor 1 transcriptional activity through Forkhead transcription factor 3a (FOXO3a)

    Brooke M. Emerling, Frank Weinberg, Juinn-Lin Liu, Tak W. Mak, and Navdeep S. Chandel

    PNAS February 19, 2008 105 (7) 2622-2627; https://doi.org/10.1073/pnas.0706790105
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    Wound angiogenesis as a function of tissue oxygen tension: A mathematical model

    Richard C. Schugart, Avner Friedman, Rui Zhao, and Chandan K. Sen

    PNAS February 19, 2008 105 (7) 2628-2633; https://doi.org/10.1073/pnas.0711642105
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    High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria

    Climent Casals-Pascual, Richard Idro, Nimmo Gicheru, Samson Gwer, Barnes Kitsao, Evelyn Gitau, Robert Mwakesi, David J. Roberts, and Charles R. J. C. Newton

    PNAS February 19, 2008 105 (7) 2634-2639; https://doi.org/10.1073/pnas.0709715105
  • Open Access

    Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression

    Farbod Shojaei, Mallika Singh, Jennifer D. Thompson, and Napoleone Ferrara

    PNAS February 19, 2008 105 (7) 2640-2645; https://doi.org/10.1073/pnas.0712185105
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    Expanded CTG repeats within the DMPK 3′ UTR causes severe skeletal muscle wasting in an inducible mouse model for myotonic dystrophy

    James P. Orengo, Pierre Chambon, Daniel Metzger, Dennis R. Mosier, G. Jackson Snipes, and Thomas A. Cooper

    PNAS February 19, 2008 105 (7) 2646-2651; https://doi.org/10.1073/pnas.0708519105
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    Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

    Li Zhao and Peter K. Vogt

    PNAS February 19, 2008 105 (7) 2652-2657; https://doi.org/10.1073/pnas.0712169105

• Microbiology

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    The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum

    Eszter Lázár-Molnár, Attila Gácser, Gordon J. Freeman, Steven C. Almo, Stanley G. Nathenson, and Joshua D. Nosanchuk

    PNAS February 19, 2008 105 (7) 2658-2663; https://doi.org/10.1073/pnas.0711918105
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    Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses

    Sheli R. Radoshitzky, Jens H. Kuhn, Christina F. Spiropoulou, César G. Albariño, Dan P. Nguyen, Jorge Salazar-Bravo, Tatyana Dorfman, Amy S. Lee, Enxiu Wang, Susan R. Ross, Hyeryun Choe, and Michael Farzan

    PNAS February 19, 2008 105 (7) 2664-2669; https://doi.org/10.1073/pnas.0709254105
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    A cell–cell signaling sensor is required for virulence and insect transmission of Xylella fastidiosa

    Subhadeep Chatterjee, Christina Wistrom, and Steven E. Lindow

    PNAS February 19, 2008 105 (7) 2670-2675; https://doi.org/10.1073/pnas.0712236105

• Neuroscience

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    Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe

    • From the Cover

    C. Brock Kirwan, Peter J. Bayley, Veronica V. Galván, and Larry R. Squire

    PNAS February 19, 2008 105 (7) 2676-2680; https://doi.org/10.1073/pnas.0712155105
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    Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Aβ toxicity

    Joel N. Buxbaum, Zhengyi Ye, Natàlia Reixach, Linsey Friske, Coree Levy, Pritam Das, Todd Golde, Eliezer Masliah, Amanda R. Roberts, and Tamas Bartfai

    PNAS February 19, 2008 105 (7) 2681-2686; https://doi.org/10.1073/pnas.0712197105
  • Open Access

    Starvation after AgRP neuron ablation is independent of melanocortin signaling

    Qi Wu, Maureen P. Howell, Michael A. Cowley, and Richard D. Palmiter

    PNAS February 19, 2008 105 (7) 2687-2692; https://doi.org/10.1073/pnas.0712062105
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    A Drosophila model for LRRK2-linked parkinsonism

    Zhaohui Liu, Xiaoyue Wang, Yi Yu, Xueping Li, Tao Wang, Haibing Jiang, Qiuting Ren, Yuchen Jiao, Akira Sawa, Timothy Moran, Christopher A. Ross, Craig Montell, and Wanli W. Smith

    PNAS February 19, 2008 105 (7) 2693-2698; https://doi.org/10.1073/pnas.0708452105
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    GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

    Jane E. Lauckner, Jill B. Jensen, Huei-Ying Chen, Hui-Chen Lu, Bertil Hille, and Ken Mackie

    PNAS February 19, 2008 105 (7) 2699-2704; https://doi.org/10.1073/pnas.0711278105
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    Anti-Ca²⁺ channel antibody attenuates Ca²⁺ currents and mimics cerebellar ataxia in vivo

    Yaping Joyce Liao, Parsa Safa, Yi-Ren Chen, Raymond A. Sobel, Edward S. Boyden, and Richard W. Tsien

    PNAS February 19, 2008 105 (7) 2705-2710; https://doi.org/10.1073/pnas.0710771105
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    BDNF is essential to promote persistence of long-term memory storage

    Pedro Bekinschtein, Martín Cammarota, Cynthia Katche, Leandro Slipczuk, Janine I. Rossato, Andrea Goldin, Ivan Izquierdo, and Jorge H. Medina

    PNAS February 19, 2008 105 (7) 2711-2716; https://doi.org/10.1073/pnas.0711863105
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    Galanin decreases proliferation of PC12 cells and induces apoptosis via its subtype 2 receptor (GalR2)

    R. Tofighi, B. Joseph, S. Xia, Z.-Q. D. Xu, B. Hamberger, T. Hökfelt, and S. Ceccatelli

    PNAS February 19, 2008 105 (7) 2717-2722; https://doi.org/10.1073/pnas.0712300105

• Pharmacology

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    IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice

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• Physiology

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    Reverse wave propagation in the cochlea

    Wenxuan He, Anders Fridberger, Edward Porsov, Karl Grosh, and Tianying Ren

    PNAS February 19, 2008 105 (7) 2729-2733; https://doi.org/10.1073/pnas.0708103105

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    Structural insight into the reaction mechanism and evolution of cytokinin biosynthesis

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    PNAS February 19, 2008 105 (7) 2734-2739; https://doi.org/10.1073/pnas.0707374105

• Population Biology

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    Reanalyses of Gulf of Mexico fisheries data: Landings can be misleading in assessments of fisheries and fisheries ecosystems

    Kim de Mutsert, James H. Cowan Jr., Timothy E. Essington, and Ray Hilborn

    PNAS February 19, 2008 105 (7) 2740-2744; https://doi.org/10.1073/pnas.0704354105

• Psychology

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    Bayesian learning of visual chunks by human observers

    Gergő Orbán, József Fiser, Richard N. Aslin, and Máté Lengyel

    PNAS February 19, 2008 105 (7) 2745-2750; https://doi.org/10.1073/pnas.0708424105