PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

Xin Huang; Fabienne Venet; Yvonne L. Wang; Alain Lepape; Zhenglong Yuan; Yaping Chen; Ryan Swan; Hakim Kherouf; Guillaume Monneret; Chun-Shiang Chung; Alfred Ayala

doi:10.1073/pnas.0809422106

New Research In

Edited by Peter A. Ward, University of Michigan Medical School, Ann Arbor, MI, and accepted by the Editorial Board February 24, 2009 (received for review October 8, 2008)

Online Impact

Article Information

vol. 106 no. 15 6303-6308

DOI:

https://doi.org/10.1073/pnas.0809422106

PubMed:

19332785

Published By:

National Academy of Sciences

Print ISSN:

0027-8424

Online ISSN:

1091-6490

History:

Published in issue April 14, 2009.
Published first March 30, 2009.

Author Information

Xin Huang^a,
Fabienne Venet^a,
Yvonne L. Wang^a,
Alain Lepape^b,
Zhenglong Yuan^a,
Yaping Chen^a,
Ryan Swan^a,
Hakim Kherouf^b,
Guillaume Monneret^b,
Chun-Shiang Chung^a and
Alfred Ayala^a,¹

^aDivision of Surgical Research, Department of Surgery, Brown University School of Medicine/Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903; and
^bImmunology Laboratory, Hospices Civils de Lyon, 69437 Lyon Cedex 03, France

Edited by Peter A. Ward, University of Michigan Medical School, Ann Arbor, MI, and accepted by the Editorial Board February 24, 2009 (received for review October 8, 2008)

Footnotes

¹To whom correspondence should be addressed. E-mail: aayala{at}lifespan.org
Author contributions: X.H., G.M., and A.A. designed research; X.H., F.V., Y.L.W., A.L., Z.Y., Y.C., R.S., H.K., and C.-S.C. performed research; X.H. and C.-S.C. analyzed data; and X.H. and A.A. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission. P.A.W. is a guest editor invited by the Editorial Board.
This article contains supporting information online at www.pnas.org/cgi/content/full/0809422106/DCSupplemental.

Cited By...

Article usage

Article usage: March 2009 to December 2019

	Abstract	Full	Pdf
Mar 2009	430	0	24
Apr 2009	2975	100	399
May 2009	337	102	105
Jun 2009	139	66	63
Jul 2009	115	54	37
Aug 2009	90	40	47
Sep 2009	190	66	61
Oct 2009	83	41	45
Nov 2009	57	55	53
Dec 2009	66	34	53
Total 2009	4482	558	887
Jan 2010	72	38	44
Feb 2010	54	41	33
Mar 2010	70	45	34
Apr 2010	59	30	29
May 2010	68	42	36
Jun 2010	71	44	31
Jul 2010	105	68	68
Aug 2010	89	54	37
Sep 2010	49	43	44
Oct 2010	70	44	39
Nov 2010	51	46	29
Dec 2010	32	29	28
Total 2010	790	524	452
Jan 2011	31	31	36
Feb 2011	29	32	29
Mar 2011	59	41	53
Apr 2011	54	33	31
May 2011	22	34	26
Jun 2011	19	22	18
Jul 2011	49	15	23
Aug 2011	39	16	24
Sep 2011	38	33	30
Oct 2011	44	40	36
Nov 2011	44	20	21
Dec 2011	38	23	31
Total 2011	466	340	358
Jan 2012	43	41	34
Feb 2012	53	32	31
Mar 2012	60	28	21
Apr 2012	31	24	20
May 2012	83	46	33
Jun 2012	75	36	24
Jul 2012	69	47	18
Aug 2012	48	22	21
Sep 2012	44	34	19
Oct 2012	71	19	18
Nov 2012	50	27	17
Dec 2012	58	32	22
Total 2012	685	388	278
Jan 2013	68	38	19
Feb 2013	165	23	26
Mar 2013	61	32	24
Apr 2013	75	31	21
May 2013	34	126	15
Jun 2013	39	36	25
Jul 2013	33	35	19
Aug 2013	47	29	21
Sep 2013	48	26	17
Oct 2013	64	42	26
Nov 2013	65	42	24
Dec 2013	40	32	18
Total 2013	739	492	255
Jan 2014	59	48	22
Feb 2014	46	40	21
Mar 2014	37	58	26
Apr 2014	44	45	31
May 2014	45	53	28
Jun 2014	60	45	19
Jul 2014	48	30	17
Aug 2014	43	43	18
Sep 2014	68	50	12
Oct 2014	57	36	20
Nov 2014	42	32	16
Dec 2014	65	30	24
Total 2014	614	510	254
Jan 2015	50	50	20
Feb 2015	50	53	26
Mar 2015	48	37	16
Apr 2015	45	26	18
May 2015	49	35	18
Jun 2015	79	20	33
Jul 2015	68	41	31
Aug 2015	67	45	23
Sep 2015	105	45	28
Oct 2015	63	54	28
Nov 2015	77	52	33
Dec 2015	82	46	38
Total 2015	783	504	312
Jan 2016	88	43	42
Feb 2016	75	40	26
Mar 2016	62	36	24
Apr 2016	61	54	29
May 2016	95	55	41
Jun 2016	75	64	29
Jul 2016	64	46	39
Aug 2016	73	27	14
Sep 2016	63	24	34
Oct 2016	50	34	26
Nov 2016	68	53	33
Dec 2016	60	57	37
Total 2016	834	533	374
Jan 2017	84	52	43
Feb 2017	62	59	31
Mar 2017	88	53	38
Apr 2017	54	23	22
May 2017	76	88	47
Jun 2017	64	81	61
Jul 2017	76	89	59
Aug 2017	74	64	57
Sep 2017	56	44	41
Oct 2017	67	68	43
Nov 2017	60	57	28
Dec 2017	43	48	40
Total 2017	804	726	510
Jan 2018	47	80	39
Feb 2018	118	124	28
Mar 2018	106	126	55
Apr 2018	94	103	44
May 2018	84	94	30
Jun 2018	56	66	39
Jul 2018	65	67	21
Aug 2018	64	55	20
Sep 2018	48	51	20
Oct 2018	22	90	36
Nov 2018	25	84	42
Dec 2018	11	53	28
Total 2018	740	993	402
Jan 2019	11	85	62
Feb 2019	8	62	23
Mar 2019	13	54	24
Apr 2019	14	65	26
May 2019	10	73	34
Jun 2019	19	74	30
Jul 2019	14	67	38
Aug 2019	9	47	31
Sep 2019	9	38	12
Oct 2019	19	58	34
Nov 2019	22	79	35
Dec 2019	4	30	10
Total 2019	152	732	359
Total	11089	6300	4441