The iron-sulfur clusters of dehydratases are primary intracellular targets of copper toxicity

Lee Macomber; James A. Imlay

doi:10.1073/pnas.0812808106

Edited by Irwin Fridovich, Duke University Medical Center, Durham, NC, and approved March 31, 2009 (received for review December 16, 2008)

Online Impact

Article Information

vol. 106 no. 20 8344-8349

DOI:

https://doi.org/10.1073/pnas.0812808106

PubMed:

19416816

Published By:

National Academy of Sciences

Print ISSN:

0027-8424

Online ISSN:

1091-6490

History:

Published in issue May 19, 2009.
Published first May 4, 2009.

Author Information

Lee Macomber and
James A. Imlay,¹

Department of Microbiology, University of Illinois, Urbana, IL 61801

Edited by Irwin Fridovich, Duke University Medical Center, Durham, NC, and approved March 31, 2009 (received for review December 16, 2008)

Footnotes

¹To whom correspondence should be addressed. E-mail: jimlay{at}illinois.edu
Author contributions: L.M. and J.A.I. designed research; L.M. performed research; L.M. and J.A.I. analyzed data; and L.M. and J.A.I. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/cgi/content/full/0812808106/DCSupplemental.

Cited By...

Article usage

Article usage: May 2009 to April 2021

	Abstract	Full	Pdf
May 2009	3643	84	448
Jun 2009	414	103	117
Jul 2009	150	81	97
Aug 2009	97	43	43
Sep 2009	124	45	65
Oct 2009	86	41	48
Nov 2009	75	36	36
Dec 2009	62	35	29
Total 2009	4651	468	883
Jan 2010	58	28	38
Feb 2010	45	70	42
Mar 2010	58	45	30
Apr 2010	37	41	26
May 2010	64	40	23
Jun 2010	39	42	23
Jul 2010	48	32	29
Aug 2010	41	25	18
Sep 2010	43	51	38
Oct 2010	36	60	33
Nov 2010	38	41	26
Dec 2010	24	37	24
Total 2010	531	512	350
Jan 2011	29	41	34
Feb 2011	21	22	16
Mar 2011	28	24	23
Apr 2011	18	15	12
May 2011	23	31	33
Jun 2011	40	27	30
Jul 2011	25	24	42
Aug 2011	23	24	32
Sep 2011	44	47	26
Oct 2011	33	34	42
Nov 2011	59	25	27
Dec 2011	50	28	22
Total 2011	393	342	339
Jan 2012	37	33	27
Feb 2012	58	33	33
Mar 2012	53	36	29
Apr 2012	39	35	38
May 2012	39	27	32
Jun 2012	36	29	22
Jul 2012	57	19	26
Aug 2012	41	21	33
Sep 2012	47	28	20
Oct 2012	41	22	38
Nov 2012	43	37	38
Dec 2012	41	25	32
Total 2012	532	345	368
Jan 2013	43	37	32
Feb 2013	38	35	28
Mar 2013	55	41	46
Apr 2013	54	37	27
May 2013	54	25	37
Jun 2013	33	30	27
Jul 2013	41	43	30
Aug 2013	24	31	17
Sep 2013	56	31	32
Oct 2013	53	44	49
Nov 2013	47	38	21
Dec 2013	38	33	25
Total 2013	536	425	371
Jan 2014	31	38	18
Feb 2014	45	27	26
Mar 2014	66	79	45
Apr 2014	77	44	37
May 2014	32	34	22
Jun 2014	38	38	34
Jul 2014	59	45	33
Aug 2014	35	26	16
Sep 2014	37	40	38
Oct 2014	72	51	36
Nov 2014	23	32	31
Dec 2014	41	28	27
Total 2014	556	482	363
Jan 2015	31	25	21
Feb 2015	47	41	21
Mar 2015	48	42	24
Apr 2015	49	67	33
May 2015	55	40	23
Jun 2015	27	30	23
Jul 2015	44	37	43
Aug 2015	43	34	23
Sep 2015	76	52	40
Oct 2015	36	41	22
Nov 2015	58	32	40
Dec 2015	50	24	19
Total 2015	564	465	332
Jan 2016	66	42	36
Feb 2016	49	40	29
Mar 2016	72	43	48
Apr 2016	50	49	28
May 2016	46	41	29
Jun 2016	39	39	26
Jul 2016	64	38	37
Aug 2016	56	48	33
Sep 2016	91	38	37
Oct 2016	84	55	38
Nov 2016	52	37	27
Dec 2016	44	23	27
Total 2016	713	493	395
Jan 2017	50	46	30
Feb 2017	79	43	32
Mar 2017	64	56	34
Apr 2017	56	29	31
May 2017	73	43	25
Jun 2017	35	34	16
Jul 2017	27	25	11
Aug 2017	48	36	32
Sep 2017	36	38	39
Oct 2017	85	44	32
Nov 2017	51	50	34
Dec 2017	38	35	34
Total 2017	642	479	350
Jan 2018	41	43	27
Feb 2018	164	162	30
Mar 2018	89	71	54
Apr 2018	84	63	41
May 2018	79	73	44
Jun 2018	78	55	26
Jul 2018	73	47	28
Aug 2018	69	64	24
Sep 2018	74	45	26
Oct 2018	35	68	29
Nov 2018	30	85	49
Dec 2018	29	74	29
Total 2018	845	850	407
Jan 2019	27	114	25
Feb 2019	15	67	26
Mar 2019	34	81	53
Apr 2019	30	99	35
May 2019	34	95	42
Jun 2019	23	82	29
Jul 2019	7	72	33
Aug 2019	18	94	51
Sep 2019	23	80	41
Oct 2019	41	93	37
Nov 2019	30	62	43
Dec 2019	17	61	27
Total 2019	299	1000	442
Jan 2020	27	90	40
Feb 2020	22	89	43
Mar 2020	24	80	39
Apr 2020	44	101	65
May 2020	26	123	40
Jun 2020	16	72	50
Jul 2020	12	65	27
Aug 2020	13	78	35
Sep 2020	21	117	48
Oct 2020	34	103	41
Nov 2020	47	70	45
Dec 2020	21	92	42
Total 2020	307	1080	515
Jan 2021	32	90	43
Feb 2021	22	119	49
Mar 2021	37	105	47
Apr 2021	17	71	29
Total 2021	108	385	168
Total	10677	7326	5283