Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements

    Sindhu Menon, Kenneth Rosenberg, Sarah A. Graham, Eliot M. Ward, Maureen E. Taylor, Kurt Drickamer, and Deborah E. Leckband

    PNAS July 14, 2009 106 (28) 11524-11529; https://doi.org/10.1073/pnas.0901783106
  • Open Access

    Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitats

    Gregor J. Devine, Elvira Zamora Perea, Gerry F. Killeen, Jeffrey D. Stancil, Suzanne J. Clark, and Amy C. Morrison

    PNAS July 14, 2009 106 (28) 11530-11534; https://doi.org/10.1073/pnas.0901369106
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    Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons

    • From the Cover

    J. Paul Simons, Raya Al-Shawi, Shane Minogue, Mark G. Waugh, Claudia Wiedemann, Stylianos Evangelou, Andrzej Loesch, Talvinder S. Sihra, Rosalind King, Thomas T. Warner, and J. Justin Hsuan

    PNAS July 14, 2009 106 (28) 11535-11539; https://doi.org/10.1073/pnas.0903011106

• Biochemistry

  • Open Access

    The archaeal cofactor F₀ is a light-harvesting antenna chromophore in eukaryotes

    Andreas F. Glas, Melanie J. Maul, Max Cryle, Thomas R. M. Barends, Sabine Schneider, Emine Kaya, Ilme Schlichting, and Thomas Carell

    PNAS July 14, 2009 106 (28) 11540-11545; https://doi.org/10.1073/pnas.0812665106
  • Open Access

    High-resolution profiling and discovery of planarian small RNAs

    Marc R. Friedländer, Catherine Adamidi, Ting Han, Svetlana Lebedeva, Thomas A. Isenbarger, Martin Hirst, Marco Marra, Chad Nusbaum, William L. Lee, James C. Jenkin, Alejandro Sánchez Alvarado, John K. Kim, and Nikolaus Rajewsky

    PNAS July 14, 2009 106 (28) 11546-11551; https://doi.org/10.1073/pnas.0905222106
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    DNA polymerase ζ cooperates with polymerases κ and ι in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients

    Omer Ziv, Nicholas Geacintov, Satoshi Nakajima, Akira Yasui, and Zvi Livneh

    PNAS July 14, 2009 106 (28) 11552-11557; https://doi.org/10.1073/pnas.0812548106
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    Structural and molecular basis of the assembly of the TRPP2/PKD1 complex

    Yong Yu, Maximilian H. Ulbrich, Ming-Hui Li, Zafir Buraei, Xing-Zhen Chen, Albert C. M. Ong, Liang Tong, Ehud Y. Isacoff, and Jian Yang

    PNAS July 14, 2009 106 (28) 11558-11563; https://doi.org/10.1073/pnas.0903684106
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    The role of transposable elements in the regulation of IFN-λ1 gene expression

    Scott J. P. Thomson, Fui G. Goh, Helen Banks, Thomas Krausgruber, Sergei V. Kotenko, Brian M. J. Foxwell, and Irina A. Udalova

    PNAS July 14, 2009 106 (28) 11564-11569; https://doi.org/10.1073/pnas.0904477106

• Biophysics and Computational Biology

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    Molecular noise of capping protein binding induces macroscopic instability in filopodial dynamics

    Pavel I. Zhuravlev and Garegin A. Papoian

    PNAS July 14, 2009 106 (28) 11570-11575; https://doi.org/10.1073/pnas.0812746106
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    Functional implications of multistage copper binding to the prion protein

    Miroslav Hodak, Robin Chisnell, Wenchang Lu, and J. Bernholc

    PNAS July 14, 2009 106 (28) 11576-11581; https://doi.org/10.1073/pnas.0903807106
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    A molecular brake, not a clutch, stops the Rhodobacter sphaeroides flagellar motor

    Teuta Pilizota, Mostyn T. Brown, Mark C. Leake, Richard W. Branch, Richard M. Berry, and Judith P. Armitage

    PNAS July 14, 2009 106 (28) 11582-11587; https://doi.org/10.1073/pnas.0813164106
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    Insertion of short transmembrane helices by the Sec61 translocon

    Simon Jaud, Mónica Fernández-Vidal, IngMarie Nilsson, Nadja M. Meindl-Beinker, Nadja C. Hübner, Douglas J. Tobias, Gunnar von Heijne, and Stephen H. White

    PNAS July 14, 2009 106 (28) 11588-11593; https://doi.org/10.1073/pnas.0900638106
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    Linking molecular affinity and cellular specificity in cadherin-mediated adhesion

    P. Katsamba, K. Carroll, G. Ahlsen, F. Bahna, J. Vendome, S. Posy, M. Rajebhosale, S. Price, T. M. Jessell, A. Ben-Shaul, L. Shapiro, and Barry H. Honig

    PNAS July 14, 2009 106 (28) 11594-11599; https://doi.org/10.1073/pnas.0905349106

• Cell Biology

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    An essential role for ATP binding and hydrolysis in the chaperone activity of GRP94 in cells

    Olga Ostrovsky, Catherine A. Makarewich, Erik L. Snapp, and Yair Argon

    PNAS July 14, 2009 106 (28) 11600-11605; https://doi.org/10.1073/pnas.0902626106
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    A site-specific, multiplexed kinase activity assay using stable-isotope dilution and high-resolution mass spectrometry

    Yonghao Yu, Rana Anjum, Kazuishi Kubota, John Rush, Judit Villen, and Steven P. Gygi

    PNAS July 14, 2009 106 (28) 11606-11611; https://doi.org/10.1073/pnas.0905165106
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    Trim24 targets endogenous p53 for degradation

    • From the Cover

    Kendra Allton, Abhinav K. Jain, Hans-Martin Herz, Wen-Wei Tsai, Sung Yun Jung, Jun Qin, Andreas Bergmann, Randy L. Johnson, and Michelle Craig Barton

    PNAS July 14, 2009 106 (28) 11612-11616; https://doi.org/10.1073/pnas.0813177106

• Developmental Biology

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    A “latent niche” mechanism for tumor initiation

    Marie McGovern, Roumen Voutev, John Maciejowski, Ann K. Corsi, and E. Jane Albert Hubbard

    PNAS July 14, 2009 106 (28) 11617-11622; https://doi.org/10.1073/pnas.0903768106
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    eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary

    Run Shen, Changjiang Weng, Junjing Yu, and Ting Xie

    PNAS July 14, 2009 106 (28) 11623-11628; https://doi.org/10.1073/pnas.0903325106

• Ecology

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    Biological consequences of earlier snowmelt from desert dust deposition in alpine landscapes

    Heidi Steltzer, Chris Landry, Thomas H. Painter, Justin Anderson, and Edward Ayres

    PNAS July 14, 2009 106 (28) 11629-11634; https://doi.org/10.1073/pnas.0900758106
  • Open Access

    Re-evaluation of forest biomass carbon stocks and lessons from the world's most carbon-dense forests

    Heather Keith, Brendan G. Mackey, and David B. Lindenmayer

    PNAS July 14, 2009 106 (28) 11635-11640; https://doi.org/10.1073/pnas.0901970106
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    Functional tradeoffs determine species coexistence via the storage effect

    Amy L. Angert, Travis E. Huxman, Peter Chesson, and D. Lawrence Venable

    PNAS July 14, 2009 106 (28) 11641-11645; https://doi.org/10.1073/pnas.0904512106
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    Extinction implications of a chenopod browse diet for a giant Pleistocene kangaroo

    Gavin J. Prideaux, Linda K. Ayliffe, Larisa R. G. DeSantis, Blaine W. Schubert, Peter F. Murray, Michael K. Gagan, and Thure E. Cerling

    PNAS July 14, 2009 106 (28) 11646-11650; first published June 25, 2009. https://doi.org/10.1073/pnas.0900956106

• Environmental Sciences

  • Open Access

    Subseafloor sedimentary life in the South Pacific Gyre

    Steven D'Hondt, Arthur J. Spivack, Robert Pockalny, Timothy G. Ferdelman, Jan P. Fischer, Jens Kallmeyer, Lewis J. Abrams, David C. Smith, Dennis Graham, Franciszek Hasiuk, Heather Schrum, and Andrea M. Stancin

    PNAS July 14, 2009 106 (28) 11651-11656; https://doi.org/10.1073/pnas.0811793106

• Evolution

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    Expected rate of fisheries-induced evolution is slow

    Ken H. Andersen and Keith Brander

    PNAS July 14, 2009 106 (28) 11657-11660; https://doi.org/10.1073/pnas.0901690106
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    Major flowering time gene, FLOWERING LOCUS C, regulates seed germination in Arabidopsis thaliana

    George C. K. Chiang, Deepak Barua, Elena M. Kramer, Richard M. Amasino, and Kathleen Donohue

    PNAS July 14, 2009 106 (28) 11661-11666; https://doi.org/10.1073/pnas.0901367106

• Genetics

  • Open Access

    Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

    Ahmad M. Khalil, Mitchell Guttman, Maite Huarte, Manuel Garber, Arjun Raj, Dianali Rivea Morales, Kelly Thomas, Aviva Presser, Bradley E. Bernstein, Alexander van Oudenaarden, Aviv Regev, Eric S. Lander, and John L. Rinn

    PNAS July 14, 2009 106 (28) 11667-11672; https://doi.org/10.1073/pnas.0904715106

• Immunology

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    Secretory phospholipase A2-IID is an effector molecule of CD4⁺CD25⁺ regulatory T cells

    Caroline E. von Allmen, Nicole Schmitz, Monika Bauer, Heather J. Hinton, Michael O. Kurrer, Regula B. Buser, Myriam Gwerder, Simone Muntwiler, Tim Sparwasser, Roger R. Beerli, and Martin F. Bachmann

    PNAS July 14, 2009 106 (28) 11673-11678; https://doi.org/10.1073/pnas.0812569106
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    Solution structure of the silkworm βGRP/GNBP3 N-terminal domain reveals the mechanism for β-1,3-glucan-specific recognition

    Kiyohiro Takahasi, Masanori Ochiai, Masataka Horiuchi, Hiroyuki Kumeta, Kenji Ogura, Masaaki Ashida, and Fuyuhiko Inagaki

    PNAS July 14, 2009 106 (28) 11679-11684; https://doi.org/10.1073/pnas.0901671106
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    GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D₄

    Akiko Maekawa, Barbara Balestrieri, K. Frank Austen, and Yoshihide Kanaoka

    PNAS July 14, 2009 106 (28) 11685-11690; https://doi.org/10.1073/pnas.0905364106

• Medical Sciences

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    NPAS3 is a trachealess homolog critical for lung development and homeostasis

    Shutang Zhou, Simone Degan, Erin N. Potts, W. Michael Foster, and Mary E. Sunday

    PNAS July 14, 2009 106 (28) 11691-11696; first published July 6, 2009. https://doi.org/10.1073/pnas.0902426106
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    Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

    Jie Lu, John S. Kovach, Francis Johnson, Jeffrey Chiang, Richard Hodes, Russell Lonser, and Zhengping Zhuang

    PNAS July 14, 2009 106 (28) 11697-11702; https://doi.org/10.1073/pnas.0905930106
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    GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism

    Yee-Ming Chan, Adelaide de Guillebon, Mariarosaria Lang-Muritano, Lacey Plummer, Felecia Cerrato, Sarah Tsiaras, Ariana Gaspert, Hélène B. Lavoie, Ching-Hui Wu, William F. Crowley Jr., John K. Amory, Nelly Pitteloud, and Stephanie B. Seminara

    PNAS July 14, 2009 106 (28) 11703-11708; https://doi.org/10.1073/pnas.0903449106

• Microbiology

  • Open Access

    Dating the emergence of pandemic influenza viruses

    • From the Cover

    Gavin J. D. Smith, Justin Bahl, Dhanasekaran Vijaykrishna, Jinxia Zhang, Leo L. M. Poon, Honglin Chen, Robert G. Webster, J. S. Malik Peiris, and Yi Guan

    PNAS July 14, 2009 106 (28) 11709-11712; https://doi.org/10.1073/pnas.0904991106
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    Structure of the vesicular stomatitis virus nucleocapsid in complex with the nucleocapsid-binding domain of the small polymerase cofactor, P

    Todd J. Green and Ming Luo

    PNAS July 14, 2009 106 (28) 11713-11718; https://doi.org/10.1073/pnas.0903228106
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    Bacteria capture iron from heme by keeping tetrapyrrol skeleton intact

    Sylvie Létoffé, Gesine Heuck, Philippe Delepelaire, Norbert Lange, and Cécile Wandersman

    PNAS July 14, 2009 106 (28) 11719-11724; https://doi.org/10.1073/pnas.0903842106
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    Toll-like receptor signaling controls reactivation of KSHV from latency

    Sean M. Gregory, John A. West, Patrick J. Dillon, Chelsey Hilscher, Dirk P. Dittmer, and Blossom Damania

    PNAS July 14, 2009 106 (28) 11725-11730; https://doi.org/10.1073/pnas.0905316106

• Neuroscience

  • Open Access

    Efficient computation of optimal actions

    • From the Cover

    Emanuel Todorov

    PNAS July 14, 2009 106 (28) 11478-11483; https://doi.org/10.1073/pnas.0710743106
  • Open Access

    Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars

    Francine M. Benes, Benjamin Lim, and Sivan Subburaju

    PNAS July 14, 2009 106 (28) 11731-11736; https://doi.org/10.1073/pnas.0903066106
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    Persistence of fear memory across time requires the basolateral amygdala complex

    Andrew M. Poulos, Veronica Li, Sarah S. Sterlace, Fonda Tokushige, Ravikumar Ponnusamy, and Michael S. Fanselow

    PNAS July 14, 2009 106 (28) 11737-11741; https://doi.org/10.1073/pnas.0905257106
  • Open Access

    Reliable neuromodulation from circuits with variable underlying structure

    Rachel Grashow, Ted Brookings, and Eve Marder

    PNAS July 14, 2009 106 (28) 11742-11746; https://doi.org/10.1073/pnas.0905614106
  • Open Access

    Cognitive fitness of cost-efficient brain functional networks

    Danielle S. Bassett, Edward T. Bullmore, Andreas Meyer-Lindenberg, José A. Apud, Daniel R. Weinberger, and Richard Coppola

    PNAS July 14, 2009 106 (28) 11747-11752; https://doi.org/10.1073/pnas.0903641106
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    Cholinergic filtering in the recurrent excitatory microcircuit of cortical layer 4

    Emmanuel Eggermann and Dirk Feldmeyer

    PNAS July 14, 2009 106 (28) 11753-11758; https://doi.org/10.1073/pnas.0810062106
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    Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice

    Albrecht Sigler, Majid H. Mohajerani, and Timothy H. Murphy

    PNAS July 14, 2009 106 (28) 11759-11764; https://doi.org/10.1073/pnas.0812695106
  • Open Access

    Changing meaning causes coupling changes within higher levels of the cortical hierarchy

    T. M. Schofield, P. Iverson, S. J. Kiebel, K. E. Stephan, J. M. Kilner, K. J. Friston, J. T. Crinion, C. J. Price, and A. P. Leff

    PNAS July 14, 2009 106 (28) 11765-11770; https://doi.org/10.1073/pnas.0811402106
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    Impaired long-term stability of CA1 place cell representation in mice lacking the transcription factor zif268/egr1

    Sophie Renaudineau, Bruno Poucet, Serge Laroche, Sabrina Davis, and Etienne Save

    PNAS July 14, 2009 106 (28) 11771-11775; https://doi.org/10.1073/pnas.0900484106
  • Open Access

    ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification

    Aaron B. Stephan, Eleen Y. Shum, Sarah Hirsh, Katherine D. Cygnar, Johannes Reisert, and Haiqing Zhao

    PNAS July 14, 2009 106 (28) 11776-11781; https://doi.org/10.1073/pnas.0903304106
  • Open Access

    Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot–Marie–Tooth neuropathy

    Erik Storkebaum, Ricardo Leitão-Gonçalves, Tanja Godenschwege, Leslie Nangle, Monica Mejia, Inge Bosmans, Tinne Ooms, An Jacobs, Patrick Van Dijck, Xiang-Lei Yang, Paul Schimmel, Koen Norga, Vincent Timmerman, Patrick Callaerts, and Albena Jordanova

    PNAS July 14, 2009 106 (28) 11782-11787; https://doi.org/10.1073/pnas.0905339106
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    High cGMP synthetic activity in carp cones

    Norihiko Takemoto, Shuji Tachibanaki, and Satoru Kawamura

    PNAS July 14, 2009 106 (28) 11788-11793; https://doi.org/10.1073/pnas.0812781106
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    Genomic–anatomic evidence for distinct functional domains in hippocampal field CA1

    Hong-Wei Dong, Larry W. Swanson, Lin Chen, Michael S. Fanselow, and Arthur W. Toga

    PNAS July 14, 2009 106 (28) 11794-11799; https://doi.org/10.1073/pnas.0812608106

• Physiology

  • Open Access

    Hypertension of Kcnmb1^−/− is linked to deficient K secretion and aldosteronism

    P. Richard Grimm, Debra L. Irsik, Deann C. Settles, J. David Holtzclaw, and Steven. C. Sansom

    PNAS July 14, 2009 106 (28) 11800-11805; https://doi.org/10.1073/pnas.0904635106

• Plant Biology

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    APC/C^CCS52A complexes control meristem maintenance in the Arabidopsis root

    Marleen Vanstraelen, Mikhail Baloban, Olivier Da Ines, Antonietta Cultrone, Tim Lammens, Véronique Boudolf, Spencer C. Brown, Lieven De Veylder, Peter Mergaert, and Eva Kondorosi

    PNAS July 14, 2009 106 (28) 11806-11811; https://doi.org/10.1073/pnas.0901193106

• Sustainability Science

  • Open Access

    Linking social norms to efficient conservation investment in payments for ecosystem services

    Xiaodong Chen, Frank Lupi, Guangming He, and Jianguo Liu

    PNAS July 14, 2009 106 (28) 11812-11817; https://doi.org/10.1073/pnas.0809980106