Table of Contents

Biological Sciences

• Anthropology

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    Shock-synthesized hexagonal diamonds in Younger Dryas boundary sediments

    Douglas J. Kennett, James P. Kennett, Allen West, G. James West, Ted E. Bunch, Brendan J. Culleton, Jon M. Erlandson, Shane S. Que Hee, John R. Johnson, Chris Mercer, Feng Shen, Marilee Sellers, Thomas W. Stafford Jr, Adrienne Stich, James C. Weaver, James H. Wittke, and Wendy S. Wolbach

    PNAS August 4, 2009 106 (31) 12623-12628; https://doi.org/10.1073/pnas.0906374106
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    Orangutans employ unique strategies to control branch flexibility

    Susannah K. S. Thorpe, Roger Holder, and Robin H. Crompton

    PNAS August 4, 2009 106 (31) 12646-12651; https://doi.org/10.1073/pnas.0811537106

• Applied Biological Sciences

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    Targeting an antimicrobial effector function in insect immunity as a pest control strategy

    Mark S. Bulmer, Ido Bachelet, Rahul Raman, Rebeca B. Rosengaus, and Ram Sasisekharan

    PNAS August 4, 2009 106 (31) 12652-12657; https://doi.org/10.1073/pnas.0904063106

• Biochemistry

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    Top-down high-resolution mass spectrometry of cardiac myosin binding protein C revealed that truncation alters protein phosphorylation state

    Ying Ge, Inna N. Rybakova, Qingge Xu, and Richard L. Moss

    PNAS August 4, 2009 106 (31) 12658-12663; https://doi.org/10.1073/pnas.0813369106
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    A model for DNA polymerase switching involving a single cleft and the rim of the sliding clamp

    Justin M. H. Heltzel, Robert W. Maul, Sarah K. Scouten Ponticelli, and Mark D. Sutton

    PNAS August 4, 2009 106 (31) 12664-12669; https://doi.org/10.1073/pnas.0903460106
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    BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

    Haiyan Huang, Tan-Jing Song, Xi Li, Lingling Hu, Qun He, Mei Liu, M. Daniel Lane, and Qi-Qun Tang

    PNAS August 4, 2009 106 (31) 12670-12675; https://doi.org/10.1073/pnas.0906266106
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    Control of p53 multimerization by Ubc13 is JNK-regulated

    Ivan Topisirovic, Gustavo J. Gutierrez, Meifan Chen, Ettore Appella, Katherine L. B. Borden, and Ze'ev A. Ronai

    PNAS August 4, 2009 106 (31) 12676-12681; https://doi.org/10.1073/pnas.0900596106
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    The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits

    Shuping Zhong and and Deborah L. Johnson

    PNAS August 4, 2009 106 (31) 12682-12687; https://doi.org/10.1073/pnas.0904843106
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    Structural transitions within human Rad51 nucleoprotein filaments

    Ragan B. Robertson, Dana N. Moses, YoungHo Kwon, Pamela Chan, Peter Chi, Hannah Klein, Patrick Sung, and Eric C. Greene

    PNAS August 4, 2009 106 (31) 12688-12693; https://doi.org/10.1073/pnas.0811465106
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    Acetate produced in the mitochondrion is the essential precursor for lipid biosynthesis in procyclic trypanosomes

    Loïc Rivière, Patrick Moreau, Stefan Allmann, Matthias Hahn, Marc Biran, Nicolas Plazolles, Jean-Michel Franconi, Michael Boshart, and Frédéric Bringaud

    PNAS August 4, 2009 106 (31) 12694-12699; https://doi.org/10.1073/pnas.0903355106
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    Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin

    Qi Wang, Marcos V. A. S. Navarro, Gary Peng, Evan Molinelli, Shih Lin Goh, Bret L. Judson, Kanagalaghatta R. Rajashankar, and Holger Sondermann

    PNAS August 4, 2009 106 (31) 12700-12705; https://doi.org/10.1073/pnas.0902974106

• Biophysics and Computational Biology

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    Solvation in protein (un)folding of melittin tetramer–monomer transition

    Christina M. Othon, Oh-Hoon Kwon, Milo M. Lin, and Ahmed H. Zewail

    PNAS August 4, 2009 106 (31) 12593-12598; https://doi.org/10.1073/pnas.0905967106
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    Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of –1 ribosomal frameshifting

    • From the Cover

    Gang Chen, Kung-Yao Chang, Ming-Yuan Chou, Carlos Bustamante, and Ignacio Tinoco Jr

    PNAS August 4, 2009 106 (31) 12706-12711; https://doi.org/10.1073/pnas.0905046106
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    The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy

    • From the Cover

    Philipp Luik, Chee Chew, Jussi Aittoniemi, Jason Chang, Paul Wentworth Jr, Raymond A. Dwek, Philip C. Biggin, Catherine Vénien-Bryan, and Nicole Zitzmann

    PNAS August 4, 2009 106 (31) 12712-12716; https://doi.org/10.1073/pnas.0905966106

    See companion article:

    • Plugging the holes in hepatitis C virus antiviral therapy

      - Aug 04, 2009
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    Why kinesin is so processive

    Erdal Toprak, Ahmet Yildiz, Melinda Tonks Hoffman, Steven S. Rosenfeld, and Paul R. Selvin

    PNAS August 4, 2009 106 (31) 12717-12722; https://doi.org/10.1073/pnas.0808396106
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    Nucleotide-dependent conformational states of actin

    Jim Pfaendtner, Davide Branduardi, Michele Parrinello, Thomas D. Pollard, and Gregory A. Voth

    PNAS August 4, 2009 106 (31) 12723-12728; https://doi.org/10.1073/pnas.0902092106
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    Cluster size regulates protein sorting in the immunological synapse

    Niña C. Hartman, Jeffrey A. Nye, and Jay T. Groves

    PNAS August 4, 2009 106 (31) 12729-12734; https://doi.org/10.1073/pnas.0902621106
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    Predicting weakly stable regions, oligomerization state, and protein–protein interfaces in transmembrane domains of outer membrane proteins

    Hammad Naveed, Ronald Jackups Jr, and Jie Liang

    PNAS August 4, 2009 106 (31) 12735-12740; https://doi.org/10.1073/pnas.0902169106
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    Transcriptome of embryonic and neonatal mouse cortex by high-throughput RNA sequencing

    Xinwei Han, Xia Wu, Wen-Yu Chung, Tao Li, Anton Nekrutenko, Naomi S. Altman, Gong Chen, and Hong Ma

    PNAS August 4, 2009 106 (31) 12741-12746; https://doi.org/10.1073/pnas.0902417106

• Cell Biology

  • Open Access

    Basal lamina strengthens cell membrane integrity via the laminin G domain-binding motif of α-dystroglycan

    • Inaugural Article

    Renzhi Han, Motoi Kanagawa, Takako Yoshida-Moriguchi, Erik P. Rader, Rainer A. Ng, Daniel E. Michele, David E. Muirhead, Stefan Kunz, Steven A. Moore, Susan T. Iannaccone, Katsuya Miyake, Paul L. McNeil, Ulrike Mayer, Michael B. A. Oldstone, John A. Faulkner, and Kevin P. Campbell

    PNAS August 4, 2009 106 (31) 12573-12579; https://doi.org/10.1073/pnas.0906545106
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    Fibroblast growth factor–2 regulates the stability of nuclear bodies

    Alexander-Francisco Bruns, Jeroen van Bergeijk, Christina Lorbeer, Anna Nölle, Julia Jungnickel, Claudia Grothe, and Peter Claus

    PNAS August 4, 2009 106 (31) 12747-12752; https://doi.org/10.1073/pnas.0900122106
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    Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis

    Alessandro Rimessi, Saverio Marchi, Carmen Fotino, Anna Romagnoli, Kay Huebner, Carlo M. Croce, Paolo Pinton, and Rosario Rizzuto

    PNAS August 4, 2009 106 (31) 12753-12758; https://doi.org/10.1073/pnas.0906484106
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    Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation

    Eirini P. Papapetrou, Mark J. Tomishima, Stuart M. Chambers, Yvonne Mica, Evan Reed, Jayanthi Menon, Viviane Tabar, Qianxing Mo, Lorenz Studer, and Michel Sadelain

    PNAS August 4, 2009 106 (31) 12759-12764; https://doi.org/10.1073/pnas.0904825106
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    Mrc1 phosphorylation in response to DNA replication stress is required for Mec1 accumulation at the stalled fork

    Maria L. Naylor, Ju-mei Li, Alex J. Osborn, and Stephen J. Elledge

    PNAS August 4, 2009 106 (31) 12765-12770; https://doi.org/10.1073/pnas.0904623106
  • Open Access

    Basal cells as stem cells of the mouse trachea and human airway epithelium

    Jason R. Rock, Mark W. Onaitis, Emma L. Rawlins, Yun Lu, Cheryl P. Clark, Yan Xue, Scott H. Randell, and Brigid L. M. Hogan

    PNAS August 4, 2009 106 (31) 12771-12775; https://doi.org/10.1073/pnas.0906850106

• Developmental Biology

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    Heterozygosity for a Bub1 mutation causes female-specific germ cell aneuploidy in mice

    Shawn Leland, Prabakaran Nagarajan, Aris Polyzos, Sharon Thomas, George Samaan, Robert Donnell, Francesco Marchetti, and Sundaresan Venkatachalam

    PNAS August 4, 2009 106 (31) 12776-12781; https://doi.org/10.1073/pnas.0903075106
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    Dendrites of cerebellar granule cells correctly recognize their target axons for synaptogenesis in vitro

    Shoko Ito and Masatoshi Takeichi

    PNAS August 4, 2009 106 (31) 12782-12787; https://doi.org/10.1073/pnas.0906653106

• Ecology

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    Global warming benefits the small in aquatic ecosystems

    Martin Daufresne, Kathrin Lengfellner, and Ulrich Sommer

    PNAS August 4, 2009 106 (31) 12788-12793; https://doi.org/10.1073/pnas.0902080106
  • Open Access

    A DNA barcode for land plants

    • From the Cover

    CBOL Plant Working Group1, Peter M. Hollingsworth, Laura L. Forrest, John L. Spouge, Mehrdad Hajibabaei, Sujeevan Ratnasingham, Michelle van der Bank, Mark W. Chase, Robyn S. Cowan, David L. Erickson, Aron J. Fazekas, Sean W. Graham, Karen E. James, Ki-Joong Kim, W. John Kress, Harald Schneider, Jonathan van AlphenStahl, Spencer C.H. Barrett, Cassio van den Berg, Diego Bogarin, Kevin S. Burgess, Kenneth M. Cameron, Mark Carine, Juliana Chacón, Alexandra Clark, James J. Clarkson, Ferozah Conrad, Dion S. Devey, Caroline S. Ford, Terry A.J. Hedderson, Michelle L. Hollingsworth, Brian C. Husband, Laura J. Kelly, Prasad R. Kesanakurti, Jung Sung Kim, Young-Dong Kim, Renaud Lahaye, Hae-Lim Lee, David G. Long, Santiago Madriñán, Olivier Maurin, Isabelle Meusnier, Steven G. Newmaster, Chong-Wook Park, Diana M. Percy, Gitte Petersen, James E. Richardson, Gerardo A. Salazar, Vincent Savolainen, Ole Seberg, Michael J. Wilkinson, Dong-Keun Yi, and Damon P. Little

    PNAS August 4, 2009 106 (31) 12794-12797; https://doi.org/10.1073/pnas.0905845106

    See companion article:

    • A botanical macroscope

      - Aug 04, 2009
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    Maternally invested carotenoids compensate costly ectoparasitism in the hihi

    John G. Ewen, Rose Thorogood, Patricia Brekke, Phillip Cassey, Filiz Karadas, and Doug P. Armstrong

    PNAS August 4, 2009 106 (31) 12798-12802; https://doi.org/10.1073/pnas.0902575106
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    Extreme diversity in noncalcifying haptophytes explains a major pigment paradox in open oceans

    Hui Liu, Ian Probert, Julia Uitz, Hervé Claustre, Stéphane Aris-Brosou, Miguel Frada, Fabrice Not, and Colomban de Vargas

    PNAS August 4, 2009 106 (31) 12803-12808; https://doi.org/10.1073/pnas.0905841106
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    Life history plasticity magnifies the ecological effects of a social wasp invasion

    Erin E. Wilson, Lynne M. Mullen, and David A. Holway

    PNAS August 4, 2009 106 (31) 12809-12813; https://doi.org/10.1073/pnas.0902979106

• Environmental Sciences

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    High diversity of fungi in air particulate matter

    Janine Fröhlich-Nowoisky, Daniel A. Pickersgill, Viviane R. Després, and Ulrich Pöschl

    PNAS August 4, 2009 106 (31) 12814-12819; https://doi.org/10.1073/pnas.0811003106

• Evolution

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    Surviving mass extinction by bridging the benthic/planktic divide

    Kate F. Darling, Ellen Thomas, Simone A. Kasemann, Heidi A. Seears, Christopher W. Smart, and Christopher M. Wade

    PNAS August 4, 2009 106 (31) 12629-12633; https://doi.org/10.1073/pnas.0902827106

    See companion article:

    • Seeking a better life in the plankton

      - Aug 25, 2009
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    Protein targeting into secondary plastids of chlorarachniophytes

    Yoshihisa Hirakawa, Kisaburo Nagamune, and Ken-ichiro Ishida

    PNAS August 4, 2009 106 (31) 12820-12825; https://doi.org/10.1073/pnas.0902578106
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    Whole-proteome phylogeny of large dsDNA virus families by an alignment-free method

    Guohong Albert Wu, Se-Ran Jun, Gregory E. Sims, and Sung-Hou Kim

    PNAS August 4, 2009 106 (31) 12826-12831; https://doi.org/10.1073/pnas.0905115106

• Genetics

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    Structure-based discovery and description of plant and animal Helitrons

    Lixing Yang and Jeffrey L. Bennetzen

    PNAS August 4, 2009 106 (31) 12832-12837; https://doi.org/10.1073/pnas.0905563106
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    Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population

    Masakazu Nakano, Yoko Ikeda, Takazumi Taniguchi, Tomohito Yagi, Masahiro Fuwa, Natsue Omi, Yuichi Tokuda, Masami Tanaka, Kengo Yoshii, Masaaki Kageyama, Shigeta Naruse, Akira Matsuda, Kazuhiko Mori, Shigeru Kinoshita, and Kei Tashiro

    PNAS August 4, 2009 106 (31) 12838-12842; https://doi.org/10.1073/pnas.0906397106
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    Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage

    Kaoru Yoshiyama, Phillip A. Conklin, Neil D. Huefner, and Anne B. Britt

    PNAS August 4, 2009 106 (31) 12843-12848; https://doi.org/10.1073/pnas.0810304106
  • Open Access

    DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway

    Hailin Wang, Meiling Lu, Moon-shong Tang, Bennett Van Houten, J. B. Alexander Ross, Michael Weinfeld, and X. Chris Le

    PNAS August 4, 2009 106 (31) 12849-12854; https://doi.org/10.1073/pnas.0902281106
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    Characterization and distribution of retrotransposons and simple sequence repeats in the bovine genome

    David L. Adelson, Joy M. Raison, and Robert C. Edgar

    PNAS August 4, 2009 106 (31) 12855-12860; https://doi.org/10.1073/pnas.0901282106
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    Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation

    Dian G. T. Su, Huafeng Fang, Michael L. Gross, and John-Stephen A. Taylor

    PNAS August 4, 2009 106 (31) 12861-12866; https://doi.org/10.1073/pnas.0902386106

• Immunology

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    DNA-triggered innate immune responses are propagated by gap junction communication

    Suraj J. Patel, Kevin R. King, Monica Casali, and Martin L. Yarmush

    PNAS August 4, 2009 106 (31) 12867-12872; https://doi.org/10.1073/pnas.0809292106
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    NOD2 contributes to cutaneous defense against Staphylococcus aureus through α-toxin-dependent innate immune activation

    Petr Hruz, Annelies S. Zinkernagel, Gabriela Jenikova, Gregory J. Botwin, Jean-Pierre Hugot, Michael Karin, Victor Nizet, and Lars Eckmann

    PNAS August 4, 2009 106 (31) 12873-12878; https://doi.org/10.1073/pnas.0904958106
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    Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo

    Caroline Sola, Pascale André, Céline Lemmers, Nicolas Fuseri, Cécile Bonnafous, Mathieu Bléry, Nicolai R. Wagtmann, François Romagné, Eric Vivier, and Sophie Ugolini

    PNAS August 4, 2009 106 (31) 12879-12884; https://doi.org/10.1073/pnas.0901653106
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    IL-9 induces differentiation of T_H17 cells and enhances function of FoxP3⁺ natural regulatory T cells

    Wassim Elyaman, Elizabeth M. Bradshaw, Catherine Uyttenhove, Valérie Dardalhon, Amit Awasthi, Jaime Imitola, Estelle Bettelli, Mohamed Oukka, Jacques van Snick, Jean-Christophe Renauld, Vijay K. Kuchroo, and Samia J. Khoury

    PNAS August 4, 2009 106 (31) 12885-12890; https://doi.org/10.1073/pnas.0812530106
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    High-affinity lamprey VLRA and VLRB monoclonal antibodies

    Satoshi Tasumi, C. Alejandro Velikovsky, Gang Xu, S. Annie Gai, K. Dane Wittrup, Martin F. Flajnik, Roy A. Mariuzza, and Zeev Pancer

    PNAS August 4, 2009 106 (31) 12891-12896; https://doi.org/10.1073/pnas.0904443106

• Medical Sciences

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    Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation

    Andrew Burke, Xuanfeng Ding, Ravi Singh, Robert A. Kraft, Nicole Levi-Polyachenko, Marissa Nichole Rylander, Chris Szot, Cara Buchanan, Jon Whitney, Jessica Fisher, Heather C. Hatcher, Ralph D'Agostino Jr., Nancy D. Kock, P. M. Ajayan, David L. Carroll, Steven Akman, Frank M. Torti, and Suzy V. Torti

    PNAS August 4, 2009 106 (31) 12897-12902; https://doi.org/10.1073/pnas.0905195106
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    Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer

    Marisa G. Ponzo, Robert Lesurf, Stephanie Petkiewicz, Frances P. O'Malley, Dushanthi Pinnaduwage, Irene L. Andrulis, Shelley B. Bull, Naila Chughtai, Dongmei Zuo, Margarita Souleimanova, David Germain, Atilla Omeroglu, Robert D. Cardiff, Michael Hallett, and Morag Park

    PNAS August 4, 2009 106 (31) 12903-12908; https://doi.org/10.1073/pnas.0810402106
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    Met induces diverse mammary carcinomas in mice and is associated with human basal breast cancer

    Carrie R. Graveel, Jack D. DeGroot, Yanli Su, Julie Koeman, Karl Dykema, Samuel Leung, Jacqueline Snider, Sherri R. Davies, Pamela J. Swiatek, Sandra Cottingham, Mark A. Watson, Matthew J. Ellis, Robert E. Sigler, Kyle A. Furge, and George F. Vande Woude

    PNAS August 4, 2009 106 (31) 12909-12914; https://doi.org/10.1073/pnas.0810403106
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    Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy

    Alexa Frentzen, Yong A. Yu, Nanhai Chen, Qian Zhang, Stephanie Weibel, Viktoria Raab, and Aladar A. Szalay

    PNAS August 4, 2009 106 (31) 12915-12920; https://doi.org/10.1073/pnas.0900660106
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    Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers

    Kishore Guda, Helen Moinova, Jian He, Oliver Jamison, Lakshmeswari Ravi, Leanna Natale, James Lutterbaugh, Earl Lawrence, Susan Lewis, James K. V. Willson, John B. Lowe, Georgia L. Wiesner, Giovanni Parmigiani, Jill Barnholtz-Sloan, Dawn W. Dawson, Victor E. Velculescu, Kenneth W. Kinzler, Nikolas Papadopoulos, Bert Vogelstein, Joseph Willis, Thomas A. Gerken, and Sanford D. Markowitz

    PNAS August 4, 2009 106 (31) 12921-12925; https://doi.org/10.1073/pnas.0901454106
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    Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation

    Yvonne S. Eisele, Tristan Bolmont, Mathias Heikenwalder, Franziska Langer, Laura H. Jacobson, Zheng-Xin Yan, Klaus Roth, Adriano Aguzzi, Matthias Staufenbiel, Lary C. Walker, and Mathias Jucker

    PNAS August 4, 2009 106 (31) 12926-12931; https://doi.org/10.1073/pnas.0903200106
  • Open Access

    The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

    Deliang Guo, Isabel J. Hildebrandt, Robert M. Prins, Horacio Soto, Mary M. Mazzotta, Julie Dang, Johannes Czernin, John Y.-J. Shyy, Andrew D. Watson, Michael Phelps, Caius G. Radu, Timothy F. Cloughesy, and Paul S. Mischel

    PNAS August 4, 2009 106 (31) 12932-12937; https://doi.org/10.1073/pnas.0906606106
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    Identification of genes conferring resistance to 5-fluorouracil

    Byoung Kwon Yoo, Rachel Gredler, Nicollaq Vozhilla, Zao-zhong Su, Dong Chen, Talitha Forcier, Khalid Shah, Utsav Saxena, Ulla Hansen, Paul B. Fisher, and Devanand Sarkar

    PNAS August 4, 2009 106 (31) 12938-12943; https://doi.org/10.1073/pnas.0901451106
  • Open Access

    Genomic analysis reveals few genetic alterations in pediatric acute myeloid leukemia

    Ina Radtke, Charles G. Mullighan, Masami Ishii, Xiaoping Su, Jinjun Cheng, Jing Ma, Ramapriya Ganti, Zhongling Cai, Salil Goorha, Stanley B. Pounds, Xueyuan Cao, Caroline Obert, Jianling Armstrong, Jinghui Zhang, Guangchun Song, Raul C. Ribeiro, Jeffrey E. Rubnitz, Susana C. Raimondi, Sheila A. Shurtleff, and James R. Downing

    PNAS August 4, 2009 106 (31) 12944-12949; https://doi.org/10.1073/pnas.0903142106
  • Open Access

    Acquired copy number alterations in adult acute myeloid leukemia genomes

    Matthew J. Walter, Jacqueline E. Payton, Rhonda E. Ries, William D. Shannon, Hrishikesh Deshmukh, Yu Zhao, Jack Baty, Sharon Heath, Peter Westervelt, Mark A. Watson, Michael H. Tomasson, Rakesh Nagarajan, Brian P. O'Gara, Clara D. Bloomfield, Krzysztof Mrózek, Rebecca R. Selzer, Todd A. Richmond, Jacob Kitzman, Joel Geoghegan, Peggy S. Eis, Rachel Maupin, Robert S. Fulton, Michael McLellan, Richard K. Wilson, Elaine R. Mardis, Daniel C. Link, Timothy A. Graubert, John F. DiPersio, and Timothy J. Ley

    PNAS August 4, 2009 106 (31) 12950-12955; https://doi.org/10.1073/pnas.0903091106
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    Role of human noncoding RNAs in the control of tumorigenesis

    Ling Li, Tingting Feng, Yingying Lian, Guangfeng Zhang, Alan Garen, and Xu Song

    PNAS August 4, 2009 106 (31) 12956-12961; https://doi.org/10.1073/pnas.0906005106
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    Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-κB activation and invasive prostate carcinoma

    Pablo J. Fernandez-Marcos, Shadi Abu-Baker, Jayashree Joshi, Anita Galvez, Elias A. Castilla, Marta Cañamero, Manuel Collado, Carmen Saez, Gema Moreno-Bueno, Jose Palacios, Michael Leitges, Manuel Serrano, Jorge Moscat, and Maria T. Diaz-Meco

    PNAS August 4, 2009 106 (31) 12962-12967; https://doi.org/10.1073/pnas.0813055106
  • Open Access

    Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

    Jan J. Molenaar, Marli E. Ebus, Dirk Geerts, Jan Koster, Fieke Lamers, Linda J. Valentijn, Ellen M. Westerhout, Rogier Versteeg, and Huib N. Caron

    PNAS August 4, 2009 106 (31) 12968-12973; https://doi.org/10.1073/pnas.0901418106
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    A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide

    Sheng Wei, Xianghong Chen, Kathy Rocha, P. K. Epling-Burnette, Julie Y. Djeu, Qing Liu, John Byrd, Lubomir Sokol, Nick Lawrence, Roberta Pireddu, Gordon Dewald, Ann Williams, Jaroslaw Maciejewski, and Alan List

    PNAS August 4, 2009 106 (31) 12974-12979; https://doi.org/10.1073/pnas.0811267106

• Microbiology

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    Large D/H variations in bacterial lipids reflect central metabolic pathways

    Xinning Zhang, Aimee L. Gillespie, and Alex L. Sessions

    PNAS August 4, 2009 106 (31) 12580-12586; https://doi.org/10.1073/pnas.0903030106

    See companion article:

    • Isotopic remembrance of metabolism past

      - Aug 04, 2009
  • Open Access

    Real-time molecular monitoring of chemical environment in obligate anaerobes during oxygen adaptive response

    Hoi-Ying N. Holman, Eleanor Wozei, Zhang Lin, Luis R. Comolli, David A. Ball, Sharon Borglin, Matthew W. Fields, Terry C. Hazen, and Kenneth H. Downing

    PNAS August 4, 2009 106 (31) 12599-12604; https://doi.org/10.1073/pnas.0902070106
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    The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation

    Hansong Ma, Ferry Hagen, Dov J. Stekel, Simon A. Johnston, Edward Sionov, Rama Falk, Itzhack Polacheck, Teun Boekhout, and Robin C. May

    PNAS August 4, 2009 106 (31) 12980-12985; https://doi.org/10.1073/pnas.0902963106
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    Biological and immunological characteristics of hepatitis E virus-like particles based on the crystal structure

    Tetsuo Yamashita, Yoshio Mori, Naoyuki Miyazaki, R. Holland Cheng, Masato Yoshimura, Hideaki Unno, Ryoichi Shima, Kohji Moriishi, Tomitake Tsukihara, Tian Cheng Li, Naokazu Takeda, Tatsuo Miyamura, and Yoshiharu Matsuura

    PNAS August 4, 2009 106 (31) 12986-12991; https://doi.org/10.1073/pnas.0903699106
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    Structure of the hepatitis E virus-like particle suggests mechanisms for virus assembly and receptor binding

    Tom S. Y. Guu, Zheng Liu, Qiaozhen Ye, Douglas A. Mata, Kunpeng Li, Changcheng Yin, Jingqiang Zhang, and Yizhi Jane Tao

    PNAS August 4, 2009 106 (31) 12992-12997; https://doi.org/10.1073/pnas.0904848106
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    Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

    Martin Blume, Dayana Rodriguez-Contreras, Scott Landfear, Tobias Fleige, Dominique Soldati-Favre, Richard Lucius, and Nishith Gupta

    PNAS August 4, 2009 106 (31) 12998-13003; https://doi.org/10.1073/pnas.0903831106
  • Open Access

    Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

    Kelley M. VanBuskirk, Matthew T. O'Neill, Patricia De La Vega, Alexander G. Maier, Urszula Krzych, Jack Williams, Megan G. Dowler, John B. Sacci Jr, Niwat Kangwanrangsan, Takafumi Tsuboi, Norman M. Kneteman, Donald G. Heppner Jr, Brant A. Murdock, Sebastian A. Mikolajczak, Ahmed S. I. Aly, Alan F. Cowman, and Stefan H. I. Kappe

    PNAS August 4, 2009 106 (31) 13004-13009; https://doi.org/10.1073/pnas.0906387106

• Neuroscience

  • Open Access

    Mechanical tension contributes to clustering of neurotransmitter vesicles at presynaptic terminals

    Scott Siechen, Shengyuan Yang, Akira Chiba, and Taher Saif

    PNAS August 4, 2009 106 (31) 12611-12616; https://doi.org/10.1073/pnas.0901867106
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    Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein

    • From the Cover

    Paula Desplats, He-Jin Lee, Eun-Jin Bae, Christina Patrick, Edward Rockenstein, Leslie Crews, Brian Spencer, Eliezer Masliah, and Seung-Jae Lee

    PNAS August 4, 2009 106 (31) 13010-13015; https://doi.org/10.1073/pnas.0903691106

    See companion article:

    • Is Parkinson's disease a prion disorder?

      - Aug 04, 2009
  • Open Access

    Marijuana craving in the brain

    Francesca M. Filbey, Joseph P. Schacht, Ursula S. Myers, Robert S. Chavez, and Kent E. Hutchison

    PNAS August 4, 2009 106 (31) 13016-13021; https://doi.org/10.1073/pnas.0903863106
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    Subcortical differentiation of stop consonants relates to reading and speech-in-noise perception

    Jane Hornickel, Erika Skoe, Trent Nicol, Steven Zecker, and Nina Kraus

    PNAS August 4, 2009 106 (31) 13022-13027; https://doi.org/10.1073/pnas.0901123106
  • Open Access

    Gain in sensitivity and loss in temporal contrast of STDP by dopaminergic modulation at hippocampal synapses

    Ji-Chuan Zhang, Pak-Ming Lau, and Guo-Qiang Bi

    PNAS August 4, 2009 106 (31) 13028-13033; https://doi.org/10.1073/pnas.0900546106
  • Open Access

    Bilateral visual field maps in a patient with only one hemisphere

    Lars Muckli, Marcus J. Naumer, and Wolf Singer

    PNAS August 4, 2009 106 (31) 13034-13039; https://doi.org/10.1073/pnas.0809688106
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    Correspondence of the brain's functional architecture during activation and rest

    Stephen M. Smith, Peter T. Fox, Karla L. Miller, David C. Glahn, P. Mickle Fox, Clare E. Mackay, Nicola Filippini, Kate E. Watkins, Roberto Toro, Angela R. Laird, and Christian F. Beckmann

    PNAS August 4, 2009 106 (31) 13040-13045; https://doi.org/10.1073/pnas.0905267106
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    Dynamic sensitivity of area V4 neurons during saccade preparation

    Xue Han, Sherry X. Xian, and Tirin Moore

    PNAS August 4, 2009 106 (31) 13046-13051; https://doi.org/10.1073/pnas.0902412106
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    Repression of α-synuclein expression and toxicity by microRNA-7

    Eunsung Junn, Kang-Woo Lee, Byeong Seon Jeong, Teresa W. Chan, Joo-Young Im, and M. Maral Mouradian

    PNAS August 4, 2009 106 (31) 13052-13057; https://doi.org/10.1073/pnas.0906277106
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    Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

    Michael E. Cahill, Zhong Xie, Michelle Day, Huzefa Photowala, Maria V. Barbolina, Courtney A. Miller, Craig Weiss, Jelena Radulovic, J. David Sweatt, John F. Disterhoft, D. James Surmeier, and Peter Penzes

    PNAS August 4, 2009 106 (31) 13058-13063; https://doi.org/10.1073/pnas.0904636106
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    Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1

    Koji Oishi, Kenji Watatani, Yasuhiro Itoh, Hideyuki Okano, François Guillemot, Kazunori Nakajima, and Yukiko Gotoh

    PNAS August 4, 2009 106 (31) 13064-13069; https://doi.org/10.1073/pnas.0808400106
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    Presynaptic peptidergic modulation of olfactory receptor neurons in Drosophila

    Rickard Ignell, Cory M. Root, Ryan T. Birse, Jing W. Wang, Dick R. Nässel, and Åsa M. E. Winther

    PNAS August 4, 2009 106 (31) 13070-13075; https://doi.org/10.1073/pnas.0813004106

• Pharmacology

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    Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation

    Takehiko Maeda, Norikazu Kiguchi, Yuka Kobayashi, Toshihiko Ikuta, Masanobu Ozaki, and Shiroh Kishioka

    PNAS August 4, 2009 106 (31) 13076-13081; https://doi.org/10.1073/pnas.0903524106

• Physiology

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    A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels

    Ahleah S. Gustina and Matthew C. Trudeau

    PNAS August 4, 2009 106 (31) 13082-13087; https://doi.org/10.1073/pnas.0900180106
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    Impaired defense mechanism against inflammation, hyperalgesia, and airway hyperreactivity in somatostatin 4 receptor gene-deleted mice

    Zsuzsanna Helyes, Erika Pintér, Katalin Sándor, Krisztián Elekes, Ágnes Bánvölgyi, Dániel Keszthelyi, Éva Szőke, Dániel M. Tóth, Zoltán Sándor, László Kereskai, Gábor Pozsgai, Jeremy P. Allen, Piers C. Emson, Adrienn Markovics, and János Szolcsányi

    PNAS August 4, 2009 106 (31) 13088-13093; https://doi.org/10.1073/pnas.0900681106
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    Duodenal acidity “sensing” but not epithelial HCO₃⁻ supply is critically dependent on carbonic anhydrase II expression

    Markus Sjöblom, Anurag Kumar Singh, Wen Zheng, Jian Wang, Bi-guang Tuo, Anja Krabbenhöft, Brigitte Riederer, Gerolf Gros, and Ursula Seidler

    PNAS August 4, 2009 106 (31) 13094-13099; https://doi.org/10.1073/pnas.0901488106
  • Open Access

    Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels

    Amandeep Singh, Martin Wirtz, Nadeene Parker, Matthew Hogan, John Strahler, George Michailidis, Sarah Schmidt, Antonio Vidal-Puig, Sabrina Diano, Philip Andrews, Martin D. Brand, and Jeffrey Friedman

    PNAS August 4, 2009 106 (31) 13100-13105; https://doi.org/10.1073/pnas.0903723106

• Plant Biology

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    Short actin-based mechanism for light-directed chloroplast movement in Arabidopsis

    Akeo Kadota, Noboru Yamada, Noriyuki Suetsugu, Mana Hirose, Chieko Saito, Keiko Shoda, Satoshi Ichikawa, Takatoshi Kagawa, Akihiko Nakano, and Masamitsu Wada

    PNAS August 4, 2009 106 (31) 13106-13111; https://doi.org/10.1073/pnas.0906250106
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    Singlet oxygen-dependent translational control in the tigrina-d.12 mutant of barley

    Dhriti Khandal, Iga Samol, Frank Buhr, Stephan Pollmann, Holger Schmidt, Stephan Clemens, Steffen Reinbothe, and Christiane Reinbothe

    PNAS August 4, 2009 106 (31) 13112-13117; https://doi.org/10.1073/pnas.0903522106
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    Sucrose synthase affects carbon partitioning to increase cellulose production and altered cell wall ultrastructure

    Heather D. Coleman, Jimmy Yan, and Shawn D. Mansfield

    PNAS August 4, 2009 106 (31) 13118-13123; https://doi.org/10.1073/pnas.0900188106
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    Normal growth of Arabidopsis requires cytosolic invertase but not sucrose synthase

    D. H. Paul Barratt, Paul Derbyshire, Kim Findlay, Marilyn Pike, Nikolaus Wellner, John Lunn, Regina Feil, Clare Simpson, Andrew J. Maule, and Alison M. Smith

    PNAS August 4, 2009 106 (31) 13124-13129; https://doi.org/10.1073/pnas.0900689106

• Psychology

  • Open Access

    Positional averaging explains crowding with letter-like stimuli

    John A. Greenwood, Peter J. Bex, and Steven C. Dakin

    PNAS August 4, 2009 106 (31) 13130-13135; https://doi.org/10.1073/pnas.0901352106

• Sustainability Science

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    Ecosocial consequences and policy implications of disease management in East African agropastoral systems

    Andrew Paul Gutierrez, Gianni Gilioli, and Johann Baumgärtner

    PNAS August 4, 2009 106 (31) 13136-13141; https://doi.org/10.1073/pnas.0813126106