Researchers are exploring whether these ubiquitous fluorinated molecules might worsen infections or hamper vaccine effectiveness.
Image credit: Shutterstock/Dmitry Naumov.
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Edited by Richard Wolfenden, University of North Carolina, Chapel Hill, NC, and approved September 11, 2009 (received for review March 11, 2009)
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PubMed:
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History:
- Published in issue November 3, 2009.
- Published first October 21, 2009.
Copyright & Usage:
© 2009
Author Information
- aDepartment of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 and
- bLaboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland
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Edited by Richard Wolfenden, University of North Carolina, Chapel Hill, NC, and approved September 11, 2009 (received for review March 11, 2009)
Footnotes
- 3To whom correspondence may be addressed. hilvert{at}org.chem.ethz.ch or wilson{at}scripps.edu
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Author contributions: E.W.D., R.M., D.H., and I.A.W. designed research; E.W.D. and R.M. performed research; E.W.D. and R.M. contributed new reagents/analytic tools; E.W.D., R.M., D.H., and I.A.W. analyzed data; and E.W.D., R.M., D.H., and I.A.W. wrote the paper.
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The authors declare no conflict of interest.
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This article is a PNAS Direct Submission.
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Data deposition: The atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org [PDB ID codes 3FO0 (hapten complex of the 13G5 wild-type), 3FO1 (hapten complex of the 113G5-GluL34Ala variant), and 3FO2 (hapten complex of the 13G5-GluL34Gln variant)].
Cited By...
Article usage
An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket
Article Classifications
- Biological Sciences
- Biochemistry
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