A perinuclear actin cap regulates nuclear shape

^aDepartment of Chemical and Biomolecular Engineering,
^dDepartment of Materials Science and Engineering,
^eJohns Hopkins Physical Science Oncology Center and Institute for NanoBioTechnology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218;
^bDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110; and
^cInstitute of Medical Biology, 8A Biomedical Grove 06-40, Immunos, Singapore 138648

Edited by Thomas D. Pollard, Yale University, New Haven, CT, and approved September 14, 2009 (received for review October 28, 2008)

Footnotes

¹To whom correspondence should be addressed. E-mail: wirtz{at}jhu.edu
Author contributions: S.B.K. and D.W. designed research; S.B.K., C.M.H., P.J.S.-H., M.S.P., D.H., and D.W. performed research; S.B.K., C.M.H., P.J.S.-H., C.L.S., P.C.S., and D.H. contributed new reagents/analytic tools; S.B.K., M.S.P., D.H., and D.W. analyzed data; and S.B.K., P.C.S., D.H., and D.W. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/cgi/content/full/0908686106/DCSupplemental.

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	Abstract	Full	Pdf
Nov 2009	2887	223	432
Dec 2009	358	103	163
Total 2009	3245	326	595
Jan 2010	202	67	93
Feb 2010	139	62	56
Mar 2010	135	59	58
Apr 2010	116	66	46
May 2010	90	45	46
Jun 2010	65	38	46
Jul 2010	56	52	38
Aug 2010	67	46	22
Sep 2010	48	52	43
Oct 2010	53	46	42
Nov 2010	57	54	44
Dec 2010	28	28	25
Total 2010	1056	615	559
Jan 2011	59	38	39
Feb 2011	76	49	58
Mar 2011	60	48	43
Apr 2011	65	41	45
May 2011	46	56	37
Jun 2011	53	32	48
Jul 2011	66	26	37
Aug 2011	62	24	30
Sep 2011	88	42	46
Oct 2011	99	45	59
Nov 2011	94	53	63
Dec 2011	77	33	41
Total 2011	845	487	546
Jan 2012	71	33	20
Feb 2012	97	34	41
Mar 2012	81	24	39
Apr 2012	97	28	38
May 2012	85	24	31
Jun 2012	58	31	29
Jul 2012	70	32	52
Aug 2012	63	22	27
Sep 2012	73	30	36
Oct 2012	63	34	42
Nov 2012	70	27	40
Dec 2012	86	36	45
Total 2012	914	355	440
Jan 2013	77	25	36
Feb 2013	87	36	38
Mar 2013	90	19	46
Apr 2013	106	21	59
May 2013	71	34	34
Jun 2013	44	25	28
Jul 2013	73	52	39
Aug 2013	41	18	20
Sep 2013	68	35	34
Oct 2013	69	46	34
Nov 2013	64	33	37
Dec 2013	48	18	16
Total 2013	838	362	421
Jan 2014	71	19	23
Feb 2014	66	25	18
Mar 2014	93	30	31
Apr 2014	81	44	51
May 2014	80	29	36
Jun 2014	78	27	29
Jul 2014	97	28	41
Aug 2014	68	34	31
Sep 2014	72	48	36
Oct 2014	80	44	18
Nov 2014	61	33	28
Dec 2014	72	36	18
Total 2014	919	397	360
Jan 2015	67	36	26
Feb 2015	72	31	22
Mar 2015	62	42	24
Apr 2015	87	33	30
May 2015	65	34	28
Jun 2015	59	26	26
Jul 2015	38	37	32
Aug 2015	57	30	30
Sep 2015	64	47	34
Oct 2015	60	56	32
Nov 2015	42	34	26
Dec 2015	47	29	32
Total 2015	720	435	342
Jan 2016	68	31	42
Feb 2016	37	30	26
Mar 2016	54	35	31
Apr 2016	44	28	14
May 2016	47	34	32
Jun 2016	55	33	21
Jul 2016	41	22	36
Aug 2016	59	44	34
Sep 2016	41	47	30
Oct 2016	46	15	16
Nov 2016	98	38	33
Dec 2016	47	38	29
Total 2016	637	395	344
Jan 2017	68	33	39
Feb 2017	44	26	16
Mar 2017	28	33	9
Apr 2017	39	20	19
May 2017	51	30	31
Jun 2017	32	23	18
Jul 2017	44	27	28
Aug 2017	56	26	40
Sep 2017	55	38	21
Oct 2017	77	49	25
Nov 2017	45	20	25
Dec 2017	40	36	19
Total 2017	579	361	290
Jan 2018	82	36	21
Feb 2018	59	54	30
Mar 2018	85	113	43
Apr 2018	123	125	34
May 2018	90	86	34
Jun 2018	77	80	28
Jul 2018	71	87	26
Aug 2018	67	73	27
Sep 2018	88	85	23
Oct 2018	22	94	37
Nov 2018	14	76	32
Dec 2018	13	77	20
Total 2018	791	986	355
Jan 2019	13	80	41
Feb 2019	10	63	25
Mar 2019	19	84	30
Apr 2019	17	92	43
May 2019	7	101	30
Jun 2019	20	117	31
Jul 2019	8	90	44
Aug 2019	16	71	44
Sep 2019	14	96	36
Oct 2019	16	107	43
Nov 2019	9	96	27
Dec 2019	4	34	30
Total 2019	153	1031	424
Total	10697	5750	4676