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Table of Contents

February 24, 2009; vol. 106 no. 8

This Week in PNAS

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    In This Issue
    PNAS February 24, 2009 106 (8) 2473-2474; https://doi.org/10.1073/iti0809106

    See companion article:

    • Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis
      - Feb 02, 2009
    • Association of FOXO3A variation with human longevity confirmed in German centenarians
      - Feb 05, 2009
    • Substitutional alloy of Ce and Al
      - Feb 02, 2009
    • Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
      - Feb 05, 2009
    • Aligned carbon nanotubes as polarization-sensitive, molecular near-field detectors
      - Feb 05, 2009

Letters (Online Only)

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    Covalent JNK inhibitors?
    David W. Borhani
    PNAS February 24, 2009 106 (8) E18; https://doi.org/10.1073/pnas.0812246106

    See companion article:

    • Reply to Borhani: Cys-dependent inhibition of JNK
      - Feb 09, 2009
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    Reply to Borhani: Cys-dependent inhibition of JNK
    Maurizio Pellecchia
    PNAS February 24, 2009 106 (8) E19; https://doi.org/10.1073/pnas.0812549106

    See companion article:

    • Covalent JNK inhibitors?
      - Feb 09, 2009
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    Ubiquitin-binding motif of human DNA polymerase η is required for correct localization
    Simone Sabbioneda, Catherine M. Green, Marzena Bienko, Patricia Kannouche, Ivan Dikic, and Alan R. Lehmann
    PNAS February 24, 2009 106 (8) E20; https://doi.org/10.1073/pnas.0812744106

    See companion article:

    • Reply to Sabbioneda et al.: Role of ubiquitin-binding motif of human DNA polymerase η in translesion synthesis
      - Feb 24, 2009
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    Reply to Sabbioneda et al.: Role of ubiquitin-binding motif of human DNA polymerase η in translesion synthesis
    Narottam Acharya, Jung-Hoon Yoon, Himabindu Gali, Ildiko Unk, Lajos Haracska, Robert E. Johnson, Jerard Hurwitz, Louise Prakash, and Satya Prakash
    PNAS February 24, 2009 106 (8) E21; https://doi.org/10.1073/pnas.0900176106

    See companion article:

    • Ubiquitin-binding motif of human DNA polymerase η is required for correct localization
      - Feb 24, 2009

Editorial

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    Darwin at 200
    Francisco J. Ayala and John C. Avise
    PNAS February 24, 2009 106 (8) 2475-2476; https://doi.org/10.1073/pnas.0900798106

Commentaries

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    Spin microscopy's heritage, achievements, and prospects
    John A. Sidles
    PNAS February 24, 2009 106 (8) 2477-2478; https://doi.org/10.1073/pnas.0813322106

    See companion article:

    • Nanoscale magnetic resonance imaging
      - Jan 12, 2009
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    Temporal tagging of attended objects
    Ernst Niebur
    PNAS February 24, 2009 106 (8) 2479-2480; https://doi.org/10.1073/pnas.0813308106

    See companion article:

    • Gamma flicker triggers attentional selection without awareness
      - Jan 05, 2009
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    It's all in a day's work: Regulation of DNA excision repair by the circadian clock
    John B. Hogenesch
    PNAS February 24, 2009 106 (8) 2481-2482; https://doi.org/10.1073/pnas.0813323106

    See companion article:

    • Circadian oscillation of nucleotide excision repair in mammalian brain
      - Jan 21, 2009

Perspective

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    Overcoming systemic roadblocks to sustainability: The evolutionary redesign of worldviews, institutions, and technologies
    • From the Cover
    Rachael Beddoe, Robert Costanza, Joshua Farley, Eric Garza, Jennifer Kent, Ida Kubiszewski, Luz Martinez, Tracy McCowen, Kathleen Murphy, Norman Myers, Zach Ogden, Kevin Stapleton, and John Woodward
    PNAS February 24, 2009 106 (8) 2483-2489; https://doi.org/10.1073/pnas.0812570106

Physical Sciences

  • Applied Mathematics

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      Elongation dynamics shape bursty transcription and translation
      Maciej Dobrzyński and Frank J. Bruggeman
      PNAS February 24, 2009 106 (8) 2583-2588; https://doi.org/10.1073/pnas.0803507106
  • Applied Physical Sciences

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      Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker
      Kun Hu, Eus J. W. Van Someren, Steven A. Shea, and Frank A. J. L. Scheer
      PNAS February 24, 2009 106 (8) 2490-2494; https://doi.org/10.1073/pnas.0806087106
    • Open Access
      Aligned carbon nanotubes as polarization-sensitive, molecular near-field detectors
      Ertugrul Cubukcu, Fatih Degirmenci, Coskun Kocabas, Mariano A. Zimmler, John A. Rogers, and Federico Capasso
      PNAS February 24, 2009 106 (8) 2495-2499; https://doi.org/10.1073/pnas.0812217106

      See companion article:

      • In This Issue
        - Feb 24, 2009
      • Connecting the dots: Reinventing optics for nanoscale dimensions
        - Mar 10, 2009
  • Chemistry

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      Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation
      Adam H. Courtney, Erik B. Puffer, Jason K. Pontrello, Zhi-Qiang Yang, and Laura L. Kiessling
      PNAS February 24, 2009 106 (8) 2500-2505; https://doi.org/10.1073/pnas.0807207106
    • Open Access
      Dislocation theory of chirality-controlled nanotube growth
      • From the Cover
      Feng Ding, Avetik R. Harutyunyan, and Boris I. Yakobson
      PNAS February 24, 2009 106 (8) 2506-2509; https://doi.org/10.1073/pnas.0811946106
    • Open Access
      Interference in acetylene intersystem crossing acts as the molecular analog of Young's double-slit experiment
      Mattijs de Groot, Robert W. Field, and Wybren J. Buma
      PNAS February 24, 2009 106 (8) 2510-2514; https://doi.org/10.1073/pnas.0809159106
  • Computer Sciences

    • Open Access
      Alignment-free genome comparison with feature frequency profiles (FFP) and optimal resolutions
      Gregory E. Sims, Se-Ran Jun, Guohong A. Wu, and Sung-Hou Kim
      PNAS February 24, 2009 106 (8) 2677-2682; https://doi.org/10.1073/pnas.0813249106
  • Engineering

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      Substitutional alloy of Ce and Al
      • From the Cover
      Qiao-Shi Zeng, Yang Ding, Wendy L. Mao, Wei Luo, Andreas Blomqvist, Rajeev Ahuja, Wenge Yang, Jinfu Shu, Stas V. Sinogeikin, Yue Meng, Dale L. Brewe, Jian-Zhong Jiang, and Ho-kwang Mao
      PNAS February 24, 2009 106 (8) 2515-2518; https://doi.org/10.1073/pnas.0813328106

      See companion article:

      • In This Issue
        - Feb 24, 2009
  • Environmental Sciences

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      Wildfire responses to abrupt climate change in North America
      J. R. Marlon, P. J. Bartlein, M. K. Walsh, S. P. Harrison, K. J. Brown, M. E. Edwards, P. E. Higuera, M. J. Power, R. S. Anderson, C. Briles, A. Brunelle, C. Carcaillet, M. Daniels, F. S. Hu, M. Lavoie, C. Long, T. Minckley, P. J. H. Richard, A. C. Scott, D. S. Shafer, W. Tinner, C. E. Umbanhowar Jr, and C. Whitlock
      PNAS February 24, 2009 106 (8) 2519-2524; https://doi.org/10.1073/pnas.0808212106

Biological Sciences

  • Biochemistry

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      MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles
      Yasnory T. F. Sasaki, Takashi Ideue, Miho Sano, Toutai Mituyama, and Tetsuro Hirose
      PNAS February 24, 2009 106 (8) 2525-2530; https://doi.org/10.1073/pnas.0807899106
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      Signals in bacterial β-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria
      Dirk M. Walther, Drazen Papic, Martine P. Bos, Jan Tommassen, and Doron Rapaport
      PNAS February 24, 2009 106 (8) 2531-2536; https://doi.org/10.1073/pnas.0807830106
    • Open Access
      Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
      • From the Cover
      Sheena McGowan, Corrine J. Porter, Jonathan Lowther, Colin M. Stack, Sarah J. Golding, Tina S. Skinner-Adams, Katharine R. Trenholme, Franka Teuscher, Sheila M. Donnelly, Jolanta Grembecka, Artur Mucha, Pawel Kafarski, Ross DeGori, Ashley M. Buckle, Donald L. Gardiner, James C. Whisstock, and John P. Dalton
      PNAS February 24, 2009 106 (8) 2537-2542; https://doi.org/10.1073/pnas.0807398106

      See companion article:

      • In This Issue
        - Feb 24, 2009
    • Open Access
      Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays
      Yifat Merbl and Marc W. Kirschner
      PNAS February 24, 2009 106 (8) 2543-2548; https://doi.org/10.1073/pnas.0812892106
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      Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin
      Laura C. Wieland Brown, Michael G. Acker, Jon Clardy, Christopher T. Walsh, and Michael A Fischbach
      PNAS February 24, 2009 106 (8) 2549-2553; https://doi.org/10.1073/pnas.0900008106
    • Open Access
      Crystal structure of human prion protein bound to a therapeutic antibody
      S. V. Antonyuk, C. R. Trevitt, R. W. Strange, G. S. Jackson, D. Sangar, M. Batchelor, S. Cooper, C. Fraser, S. Jones, T. Georgiou, A. Khalili-Shirazi, A. R. Clarke, S. S. Hasnain, and J. Collinge
      PNAS February 24, 2009 106 (8) 2554-2558; https://doi.org/10.1073/pnas.0809170106
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      Principal determinants leading to transition state formation of a protein–protein complex, orientation trumps side-chain interactions
      James R. Horn, Tobin R. Sosnick, and Anthony A. Kossiakoff
      PNAS February 24, 2009 106 (8) 2559-2564; https://doi.org/10.1073/pnas.0809800106
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      The cardiac glycoside binding site on the Na,K-ATPase α2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle
      T. L. Radzyukevich, J. B Lingrel, and J. A. Heiny
      PNAS February 24, 2009 106 (8) 2565-2570; https://doi.org/10.1073/pnas.0804150106
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      Following movement of the L1 stalk between three functional states in single ribosomes
      Peter V. Cornish, Dmitri N. Ermolenko, David W. Staple, Lee Hoang, Robyn P. Hickerson, Harry F. Noller, and Taekjip Ha
      PNAS February 24, 2009 106 (8) 2571-2576; https://doi.org/10.1073/pnas.0813180106
    • Open Access
      Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron
      Sumit Borah, Anthony C. Wong, and Joan A. Steitz
      PNAS February 24, 2009 106 (8) 2577-2582; https://doi.org/10.1073/pnas.0812826106
  • Biophysics

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      Elongation dynamics shape bursty transcription and translation
      Maciej Dobrzyński and Frank J. Bruggeman
      PNAS February 24, 2009 106 (8) 2583-2588; https://doi.org/10.1073/pnas.0803507106
    • Open Access
      Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter
      Yan Gu, Indira H. Shrivastava, Susan G. Amara, and Ivet Bahar
      PNAS February 24, 2009 106 (8) 2589-2594; https://doi.org/10.1073/pnas.0812299106
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      Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group
      Woon Ki Lim, Jörg Rösgen, and S. Walter Englander
      PNAS February 24, 2009 106 (8) 2595-2600; https://doi.org/10.1073/pnas.0812588106
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      Rational stabilization of enzymes by computational redesign of surface charge–charge interactions
      Alexey V. Gribenko, Mayank M. Patel, Jiajing Liu, Scott A. McCallum, Chunyu Wang, and George I. Makhatadze
      PNAS February 24, 2009 106 (8) 2601-2606; https://doi.org/10.1073/pnas.0808220106
    • Open Access
      Identifying essential genes in Escherichia coli from a metabolic optimization principle
      Carlotta Martelli, Andrea De Martino, Enzo Marinari, Matteo Marsili, and Isaac Pérez Castillo
      PNAS February 24, 2009 106 (8) 2607-2611; https://doi.org/10.1073/pnas.0813229106
    • Open Access
      Visualizing breathing motion of internal cavities in concert with ligand migration in myoglobin
      Ayana Tomita, Tokushi Sato, Kouhei Ichiyanagi, Shunsuke Nozawa, Hirohiko Ichikawa, Matthieu Chollet, Fumihiro Kawai, Sam-Yong Park, Takayuki Tsuduki, Takahisa Yamato, Shin-ya Koshihara, and Shin-ichi Adachi
      PNAS February 24, 2009 106 (8) 2612-2616; https://doi.org/10.1073/pnas.0807774106
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      ARNT PAS-B has a fragile native state structure with an alternative β-sheet register nearby in sequence space
      Matthew R. Evans, Paul B. Card, and Kevin H. Gardner
      PNAS February 24, 2009 106 (8) 2617-2622; https://doi.org/10.1073/pnas.0808270106
  • Cell Biology

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      Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation
      Yu Wang, Zhe Zhou, Christopher T. Walsh, and Andrew P. McMahon
      PNAS February 24, 2009 106 (8) 2623-2628; first published February 5, 2009. https://doi.org/10.1073/pnas.0812110106
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      Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP
      Yifeng Xia, Roanna C. Padre, Tatiana Hurtado De Mendoza, Virginie Bottero, Vinay B. Tergaonkar, and Inder M. Verma
      PNAS February 24, 2009 106 (8) 2629-2634; https://doi.org/10.1073/pnas.0812256106
    • Open Access
      Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells
      Jane J. Yu, Victoria A. Robb, Tasha A. Morrison, Eric A. Ariazi, Magdalena Karbowniczek, Aristotelis Astrinidis, Chunrong Wang, Lisa Hernandez-Cuebas, Laura F. Seeholzer, Emmanuelle Nicolas, Harvey Hensley, V. Craig Jordan, Cheryl L. Walker, and Elizabeth P. Henske
      PNAS February 24, 2009 106 (8) 2635-2640; https://doi.org/10.1073/pnas.0810790106
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      Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus
      Alexandros Tzatsos, Raymond Pfau, Sotirios C. Kampranis, and Philip N. Tsichlis
      PNAS February 24, 2009 106 (8) 2641-2646; https://doi.org/10.1073/pnas.0813139106
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      Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex
      Cynthia K. Shrum, Daniel DeFrancisco, and Mollie K. Meffert
      PNAS February 24, 2009 106 (8) 2647-2652; https://doi.org/10.1073/pnas.0806677106
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      Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells
      Luiz C. Godoy, Cristina Muñoz-Pinedo, Laura Castro, Simone Cardaci, Christopher M. Schonhoff, Michael King, Verónica Tórtora, Mónica Marín, Qian Miao, Jian Fei Jiang, Alexandr Kapralov, Ronald Jemmerson, Gary G. Silkstone, Jinal N. Patel, James E. Evans, Michael T. Wilson, Douglas R. Green, Valerian E. Kagan, Rafael Radi, and Joan B. Mannick
      PNAS February 24, 2009 106 (8) 2653-2658; https://doi.org/10.1073/pnas.0809279106
  • Developmental Biology

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      Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase
      Bernadette M. Glasheen, Aashish T. Kabra, and Andrea Page-McCaw
      PNAS February 24, 2009 106 (8) 2659-2664; https://doi.org/10.1073/pnas.0804171106
  • Ecology

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      Contrasting size evolution in marine and freshwater diatoms
      E. Litchman, C. A. Klausmeier, and K. Yoshiyama
      PNAS February 24, 2009 106 (8) 2665-2670; https://doi.org/10.1073/pnas.0810891106
    • Open Access
      Culling experiments demonstrate size-class specific biomass increases with mortality
      A. Schröder, L. Persson, and A. M. de Roos
      PNAS February 24, 2009 106 (8) 2671-2676; https://doi.org/10.1073/pnas.0808279106
  • Evolution

    • Open Access
      Alignment-free genome comparison with feature frequency profiles (FFP) and optimal resolutions
      Gregory E. Sims, Se-Ran Jun, Guohong A. Wu, and Sung-Hou Kim
      PNAS February 24, 2009 106 (8) 2677-2682; https://doi.org/10.1073/pnas.0813249106
    • You have access
      Tri-split tRNA is a transfer RNA made from 3 transcripts that provides insight into the evolution of fragmented tRNAs in archaea
      Kosuke Fujishima, Junichi Sugahara, Kaoru Kikuta, Reiko Hirano, Asako Sato, Masaru Tomita, and Akio Kanai
      PNAS February 24, 2009 106 (8) 2683-2687; https://doi.org/10.1073/pnas.0808246106
  • Genetics

    • Open Access
      Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
      Silvia Poláková, Christian Blume, Julián Álvarez Zárate, Marek Mentel, Dorte Jørck-Ramberg, Jørgen Stenderup, and Jure Piškur
      PNAS February 24, 2009 106 (8) 2688-2693; https://doi.org/10.1073/pnas.0809793106
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      Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease
      Maria-Mercè Garcia-Barcelo, Clara Sze-man Tang, Elly Sau-wai Ngan, Vincent Chi-hang Lui, Yan Chen, Man-ting So, Thomas Yuk-yu Leon, Xiao-ping Miao, Cathy Ka-yee Shum, Feng-qin Liu, Ming-yiu Yeung, Zhen-wei Yuan, Wei-hong Guo, Lei Liu, Xiao-bing Sun, Liu-ming Huang, Jin-fa Tou, You-qiang Song, Danny Chan, Kenneth M. C. Cheung, Kenneth Kak-yuen Wong, Stacey S. Cherny, Pak-chung Sham, and Paul Kwong-hang Tam
      PNAS February 24, 2009 106 (8) 2694-2699; https://doi.org/10.1073/pnas.0809630105
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      Association of FOXO3A variation with human longevity confirmed in German centenarians
      Friederike Flachsbart, Amke Caliebe, Rabea Kleindorp, Hélène Blanché, Huberta von Eller-Eberstein, Susanna Nikolaus, Stefan Schreiber, and Almut Nebel
      PNAS February 24, 2009 106 (8) 2700-2705; https://doi.org/10.1073/pnas.0809594106

      See companion article:

      • In This Issue
        - Feb 24, 2009
    • You have access
      Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
      Amanda L. Blasius, Katharina Brandl, Karine Crozat, Yu Xia, Kevin Khovananth, Philippe Krebs, Nora G. Smart, Antonella Zampolli, Zaverio M. Ruggeri, and Bruce A. Beutler
      PNAS February 24, 2009 106 (8) 2706-2711; https://doi.org/10.1073/pnas.0813208106
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      Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
      Haihao Zhu, Jaime Acquaviva, Pranatartiharan Ramachandran, Abraham Boskovitz, Steve Woolfenden, Rolf Pfannl, Roderick T. Bronson, John W. Chen, Ralph Weissleder, David E. Housman, and Al Charest
      PNAS February 24, 2009 106 (8) 2712-2716; https://doi.org/10.1073/pnas.0813314106
  • Immunology

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      Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation
      Adam H. Courtney, Erik B. Puffer, Jason K. Pontrello, Zhi-Qiang Yang, and Laura L. Kiessling
      PNAS February 24, 2009 106 (8) 2500-2505; https://doi.org/10.1073/pnas.0807207106
    • You have access
      Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice
      Hwei-Ling Cheng, Bao Q. Vuong, Uttiya Basu, Andrew Franklin, Bjoern Schwer, Jillian Astarita, Ryan T. Phan, Abhishek Datta, John Manis, Frederick W. Alt, and Jayanta Chaudhuri
      PNAS February 24, 2009 106 (8) 2717-2722; https://doi.org/10.1073/pnas.0812304106
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      Perforin-mediated suppression of B-cell lymphoma
      Paul Bolitho, Shayna E. A. Street, Jennifer A. Westwood, Winfried Edelmann, Duncan MacGregor, Paul Waring, William K. Murray, Dale I. Godfrey, Joseph A. Trapani, Ricky W. Johnstone, and Mark J. Smyth
      PNAS February 24, 2009 106 (8) 2723-2728; https://doi.org/10.1073/pnas.0809008106
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      Anti-CTLA-4 therapy results in higher CD4+ICOShi T cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissues
      Hong Chen, Chrysoula I. Liakou, Ashish Kamat, Curtis Pettaway, John F. Ward, Derek Ng Tang, Jingjing Sun, Achim A. Jungbluth, Patricia Troncoso, Christopher Logothetis, and Padmanee Sharma
      PNAS February 24, 2009 106 (8) 2729-2734; https://doi.org/10.1073/pnas.0813175106
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      MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells
      Maurizio Ceppi, Patricia M. Pereira, Isabelle Dunand-Sauthier, Emmanuèle Barras, Walter Reith, Manuel A. Santos, and Philippe Pierre
      PNAS February 24, 2009 106 (8) 2735-2740; https://doi.org/10.1073/pnas.0811073106
    • Open Access
      B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation
      Oezcan Talay, Ching-Hung Shen, Lieping Chen, and Jianzhu Chen
      PNAS February 24, 2009 106 (8) 2741-2746; https://doi.org/10.1073/pnas.0813367106
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      Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
      Taichiro Nonaka, Tomomitsu Doi, Takae Toyoshima, Masamichi Muramatsu, Tasuku Honjo, and Kazuo Kinoshita
      PNAS February 24, 2009 106 (8) 2747-2751; https://doi.org/10.1073/pnas.0812957106
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      Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
      Nasim A. Begum, Andre Stanlie, Tomomitsu Doi, Yoko Sasaki, Hai Wei Jin, Yong Sung Kim, Hitoshi Nagaoka, and Tasuku Honjo
      PNAS February 24, 2009 106 (8) 2752-2757; https://doi.org/10.1073/pnas.0813252106
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      The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
      Tomomitsu Doi, Lucia Kato, Satomi Ito, Reiko Shinkura, Min Wei, Hitoshi Nagaoka, Jishu Wang, and Tasuku Honjo
      PNAS February 24, 2009 106 (8) 2758-2763; https://doi.org/10.1073/pnas.0813253106
    • Open Access
      Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7
      Tomoko Hayashi, Christine S. Gray, Michael Chan, Rommel I. Tawatao, Lisa Ronacher, Maureen A. McGargill, Sandip K. Datta, Dennis A. Carson, and Maripat Corr
      PNAS February 24, 2009 106 (8) 2764-2769; https://doi.org/10.1073/pnas.0813037106
    • You have access
      Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
      Michal Caspi Tal, Miwa Sasai, Heung Kyu Lee, Brian Yordy, Gerald S. Shadel, and Akiko Iwasaki
      PNAS February 24, 2009 106 (8) 2770-2775; https://doi.org/10.1073/pnas.0807694106
    • You have access
      Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes
      Jan Petersen, Stephanie J. Wurzbacher, Nicholas A. Williamson, Sri H. Ramarathinam, Hugh H. Reid, Ashish K. N. Nair, Anne Y. Zhao, Roza Nastovska, Geordie Rudge, Jamie Rossjohn, and Anthony W. Purcell
      PNAS February 24, 2009 106 (8) 2776-2781; https://doi.org/10.1073/pnas.0812901106
    • You have access
      The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response
      Jennifer R. Powell, Dennis H. Kim, and Frederick M. Ausubel
      PNAS February 24, 2009 106 (8) 2782-2787; https://doi.org/10.1073/pnas.0813048106
    • You have access
      Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice
      Héctor Pérez Montoyo, Carlos Vaccaro, Martin Hafner, Raimund J. Ober, Werner Mueller, and E. Sally Ward
      PNAS February 24, 2009 106 (8) 2788-2793; https://doi.org/10.1073/pnas.0810796106
  • Medical Sciences

    • Open Access
      Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis
      Tomoyuki Awano, Gary S. Johnson, Claire M. Wade, Martin L. Katz, Gayle C. Johnson, Jeremy F. Taylor, Michele Perloski, Tara Biagi, Izabella Baranowska, Sam Long, Philip A. March, Natasha J. Olby, G. Diane Shelton, Shahnawaz Khan, Dennis P. O'Brien, Kerstin Lindblad-Toh, and Joan R. Coates
      PNAS February 24, 2009 106 (8) 2794-2799; https://doi.org/10.1073/pnas.0812297106

      See companion article:

      • In This Issue
        - Feb 24, 2009
    • You have access
      Anti-laminin gamma-1 pemphigoid
      Teruki Dainichi, Sadamu Kurono, Bungo Ohyama, Norito Ishii, Noriko Sanzen, Maria Hayashi, Chisei Shimono, Yukimasa Taniguchi, Hiroshi Koga, Tadashi Karashima, Shinichiro Yasumoto, Detlef Zillikens, Kiyotoshi Sekiguchi, and Takashi Hashimoto
      PNAS February 24, 2009 106 (8) 2800-2805; https://doi.org/10.1073/pnas.0809230106
    • You have access
      β-Arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis
      Laura Rosanò, Roberta Cianfrocca, Stefano Masi, Francesca Spinella, Valeriana Di Castro, Annamaria Biroccio, Erica Salvati, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato
      PNAS February 24, 2009 106 (8) 2806-2811; https://doi.org/10.1073/pnas.0807158106
    • Open Access
      The miR-17∼92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma
      Tamar Uziel, Fedor V. Karginov, Suqing Xie, Joel S. Parker, Yong-Dong Wang, Amar Gajjar, Lin He, David Ellison, Richard J. Gilbertson, Gregory Hannon, and Martine F. Roussel
      PNAS February 24, 2009 106 (8) 2812-2817; https://doi.org/10.1073/pnas.0809579106
    • You have access
      Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
      Leah E. Cowen, Sheena D. Singh, Julia R. Köhler, Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Hamza Aziz, Eleftherios Mylonakis, John R. Perfect, Luke Whitesell, and Susan Lindquist
      PNAS February 24, 2009 106 (8) 2818-2823; https://doi.org/10.1073/pnas.0813394106

      See companion article:

      • Dynamic duo takes down fungal villains
        - Feb 26, 2009
    • Open Access
      Prognostic gene signatures for non-small-cell lung cancer
      Paul C. Boutros, Suzanne K. Lau, Melania Pintilie, Ni Liu, Frances A. Shepherd, Sandy D. Der, Ming-Sound Tsao, Linda Z. Penn, and Igor Jurisica
      PNAS February 24, 2009 106 (8) 2824-2828; https://doi.org/10.1073/pnas.0809444106
    • Open Access
      Potassium softens vascular endothelium and increases nitric oxide release
      H. Oberleithner, C. Callies, K. Kusche-Vihrog, H. Schillers, V. Shahin, C. Riethmüller, G. A. MacGregor, and H. E. de Wardener
      PNAS February 24, 2009 106 (8) 2829-2834; https://doi.org/10.1073/pnas.0813069106
    • Open Access
      Knockin of mutant PIK3CA activates multiple oncogenic pathways
      John P. Gustin, Bedri Karakas, Michele B. Weiss, Abde M. Abukhdeir, Josh Lauring, Joseph P. Garay, David Cosgrove, Akina Tamaki, Hiroyuki Konishi, Yuko Konishi, Morassa Mohseni, Grace Wang, D. Marc Rosen, Samuel R. Denmeade, Michaela J. Higgins, Michele I. Vitolo, Kurtis E. Bachman, and Ben Ho Park
      PNAS February 24, 2009 106 (8) 2835-2840; https://doi.org/10.1073/pnas.0813351106
    • Open Access
      Loss of cryptochrome reduces cancer risk in p53 mutant mice
      Nuri Ozturk, Jin Hyup Lee, Shobhan Gaddameedhi, and Aziz Sancar
      PNAS February 24, 2009 106 (8) 2841-2846; https://doi.org/10.1073/pnas.0813028106
    • Open Access
      Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography
      Rachel E. Laing, Martin A. Walter, Dean O. Campbell, Harvey R. Herschman, Nagichettiar Satyamurthy, Michael E. Phelps, Johannes Czernin, Owen N. Witte, and Caius G. Radu
      PNAS February 24, 2009 106 (8) 2847-2852; https://doi.org/10.1073/pnas.0812890106
    • You have access
      Transforming activity of AML1-ETO is independent of CBFβ and ETO interaction but requires formation of homo-oligomeric complexes
      Colin Kwok, Bernd B. Zeisig, Jihui Qiu, Shuo Dong, and Chi Wai Eric So
      PNAS February 24, 2009 106 (8) 2853-2858; https://doi.org/10.1073/pnas.0810558106
    • You have access
      A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia
      Paloma Alonso-Magdalena, Clemens Brössner, Angelika Reiner, Guojun Cheng, Nobuhiro Sugiyama, Margaret Warner, and Jan-Åke Gustafsson
      PNAS February 24, 2009 106 (8) 2859-2863; https://doi.org/10.1073/pnas.0812666106
    • Open Access
      Circadian oscillation of nucleotide excision repair in mammalian brain
      • From the Cover
      Tae-Hong Kang, Joyce T. Reardon, Michael Kemp, and Aziz Sancar
      PNAS February 24, 2009 106 (8) 2864-2867; https://doi.org/10.1073/pnas.0812638106

      See companion article:

      • It's all in a day's work: Regulation of DNA excision repair by the circadian clock
        - Feb 24, 2009
    • You have access
      Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion
      Eri Miyagi, Amy J. Andrew, Sandra Kao, and Klaus Strebel
      PNAS February 24, 2009 106 (8) 2868-2873; https://doi.org/10.1073/pnas.0813223106
  • Microbiology

    • Open Access
      Genomic reconstruction of Shewanella oneidensis MR-1 metabolism reveals a previously uncharacterized machinery for lactate utilization
      Grigory E. Pinchuk, Dmitry A. Rodionov, Chen Yang, Xiaoqing Li, Andrei L. Osterman, Etienne Dervyn, Oleg V. Geydebrekht, Samantha B. Reed, Margaret F. Romine, Frank R. Collart, James H. Scott, Jim K. Fredrickson, and Alexander S. Beliaev
      PNAS February 24, 2009 106 (8) 2874-2879; https://doi.org/10.1073/pnas.0806798106
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      Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B
      Marija Backovic, Richard Longnecker, and Theodore S. Jardetzky
      PNAS February 24, 2009 106 (8) 2880-2885; https://doi.org/10.1073/pnas.0810530106
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      Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein
      Rachel L. Kaletsky, Joseph R. Francica, Caroline Agrawal-Gamse, and Paul Bates
      PNAS February 24, 2009 106 (8) 2886-2891; https://doi.org/10.1073/pnas.0811014106
  • Neuroscience

    • You have access
      Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker
      Kun Hu, Eus J. W. Van Someren, Steven A. Shea, and Frank A. J. L. Scheer
      PNAS February 24, 2009 106 (8) 2490-2494; https://doi.org/10.1073/pnas.0806087106
    • You have access
      Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy
      Jill R. Crittenden, Ippolita Cantuti-Castelvetri, Esen Saka, Christine E. Keller-McGandy, Ledia F. Hernandez, Lauren R. Kett, Anne B. Young, David G. Standaert, and Ann M. Graybiel
      PNAS February 24, 2009 106 (8) 2892-2896; https://doi.org/10.1073/pnas.0812822106

      See companion article:

      • Levodopa-induced dyskinesia and striatal signaling pathways
        - Feb 26, 2009
    • You have access
      CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
      Han Seok Ko, Rachel Bailey, Wanli W. Smith, Zhaohui Liu, Joo-Ho Shin, Yun-Il Lee, Yong-Jie Zhang, Haibing Jiang, Christopher A. Ross, Darren J. Moore, Cam Patterson, Leonard Petrucelli, Ted M. Dawson, and Valina L. Dawson
      PNAS February 24, 2009 106 (8) 2897-2902; https://doi.org/10.1073/pnas.0810123106
    • Open Access
      Discovery of a functional protein complex of netrin-4, laminin γ1 chain, and integrin α6β1 in mouse neural stem cells
      Fernanda I. Staquicini, Emmanuel Dias-Neto, Jianxue Li, Evan Y. Snyder, Richard L. Sidman, Renata Pasqualini, and Wadih Arap
      PNAS February 24, 2009 106 (8) 2903-2908; https://doi.org/10.1073/pnas.0813286106
    • You have access
      TOX3 regulates calcium-dependent transcription in neurons
      Shauna H. Yuan, Zilong Qiu, and Anirvan Ghosh
      PNAS February 24, 2009 106 (8) 2909-2914; https://doi.org/10.1073/pnas.0805555106
    • You have access
      Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens
      Yong Kim, Merilee A. Teylan, Matthew Baron, Adam Sands, Angus C. Nairn, and Paul Greengard
      PNAS February 24, 2009 106 (8) 2915-2920; https://doi.org/10.1073/pnas.0813179106
    • Open Access
      Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition
      Asif K. Mustafa, Damian B. van Rossum, Randen L. Patterson, David Maag, Jeffrey T. Ehmsen, Sadia K. Gazi, Anutosh Chakraborty, Roxanne K. Barrow, L. Mario Amzel, and Solomon H. Snyder
      PNAS February 24, 2009 106 (8) 2921-2926; https://doi.org/10.1073/pnas.0813105106
    • You have access
      Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi
      Christina Dalla, Efstathios B. Papachristos, Abigail S. Whetstone, and Tracey J. Shors
      PNAS February 24, 2009 106 (8) 2927-2932; https://doi.org/10.1073/pnas.0809650106
    • You have access
      Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte
      Pei-Chun Chen, Marcelo R. Vargas, Amar K. Pani, Richard J. Smeyne, Delinda A. Johnson, Yuet Wai Kan, and Jeffrey A. Johnson
      PNAS February 24, 2009 106 (8) 2933-2938; https://doi.org/10.1073/pnas.0813361106
    • Open Access
      Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations
      Jonathan E. Rubin, John A. Hayes, Jeffrey L. Mendenhall, and Christopher A. Del Negro
      PNAS February 24, 2009 106 (8) 2939-2944; https://doi.org/10.1073/pnas.0808776106
    • You have access
      Counting the number of releasable synaptic vesicles in a presynaptic terminal
      Kaori Ikeda and John M. Bekkers
      PNAS February 24, 2009 106 (8) 2945-2950; https://doi.org/10.1073/pnas.0811017106
    • You have access
      DSCAM functions as a netrin receptor in commissural axon pathfinding
      Guofa Liu, Weiquan Li, Lei Wang, Amar Kar, Kun-Liang Guan, Yi Rao, and Jane Y. Wu
      PNAS February 24, 2009 106 (8) 2951-2956; https://doi.org/10.1073/pnas.0811083106
  • Physiology

    • You have access
      An oxygen-sensitive mechanism in regulation of epithelial sodium channel
      Su Wang, Stephen Publicover, and Yuchun Gu
      PNAS February 24, 2009 106 (8) 2957-2962; https://doi.org/10.1073/pnas.0809100106
  • Psychology

    • Open Access
      Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1
      Elizabeth A. Shirtcliff, Christopher L. Coe, and Seth D. Pollak
      PNAS February 24, 2009 106 (8) 2963-2967; https://doi.org/10.1073/pnas.0806660106

Correction

  • You have access
    Correction for Sebastian et al., Fractalization drives crystalline states in a frustrated spin system
    PNAS February 24, 2009 106 (8) 2968; https://doi.org/10.1073/pnas.0812760106
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Proceedings of the National Academy of Sciences: 106 (8)
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