Table of Contents

Biological Sciences

• Biochemistry

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    MENε/β noncoding RNAs are essential for structural integrity of nuclear paraspeckles

    Yasnory T. F. Sasaki, Takashi Ideue, Miho Sano, Toutai Mituyama, and Tetsuro Hirose

    PNAS February 24, 2009 106 (8) 2525-2530; https://doi.org/10.1073/pnas.0807899106
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    Signals in bacterial β-barrel proteins are functional in eukaryotic cells for targeting to and assembly in mitochondria

    Dirk M. Walther, Drazen Papic, Martine P. Bos, Jan Tommassen, and Doron Rapaport

    PNAS February 24, 2009 106 (8) 2531-2536; https://doi.org/10.1073/pnas.0807830106
  • Open Access

    Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

    • From the Cover

    Sheena McGowan, Corrine J. Porter, Jonathan Lowther, Colin M. Stack, Sarah J. Golding, Tina S. Skinner-Adams, Katharine R. Trenholme, Franka Teuscher, Sheila M. Donnelly, Jolanta Grembecka, Artur Mucha, Pawel Kafarski, Ross DeGori, Ashley M. Buckle, Donald L. Gardiner, James C. Whisstock, and John P. Dalton

    PNAS February 24, 2009 106 (8) 2537-2542; https://doi.org/10.1073/pnas.0807398106

    See companion article:

    • In This Issue

      - Feb 24, 2009
  • Open Access

    Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays

    Yifat Merbl and Marc W. Kirschner

    PNAS February 24, 2009 106 (8) 2543-2548; https://doi.org/10.1073/pnas.0812892106
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    Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

    Laura C. Wieland Brown, Michael G. Acker, Jon Clardy, Christopher T. Walsh, and Michael A Fischbach

    PNAS February 24, 2009 106 (8) 2549-2553; https://doi.org/10.1073/pnas.0900008106
  • Open Access

    Crystal structure of human prion protein bound to a therapeutic antibody

    S. V. Antonyuk, C. R. Trevitt, R. W. Strange, G. S. Jackson, D. Sangar, M. Batchelor, S. Cooper, C. Fraser, S. Jones, T. Georgiou, A. Khalili-Shirazi, A. R. Clarke, S. S. Hasnain, and J. Collinge

    PNAS February 24, 2009 106 (8) 2554-2558; https://doi.org/10.1073/pnas.0809170106
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    Principal determinants leading to transition state formation of a protein–protein complex, orientation trumps side-chain interactions

    James R. Horn, Tobin R. Sosnick, and Anthony A. Kossiakoff

    PNAS February 24, 2009 106 (8) 2559-2564; https://doi.org/10.1073/pnas.0809800106
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    The cardiac glycoside binding site on the Na,K-ATPase α2 isoform plays a role in the dynamic regulation of active transport in skeletal muscle

    T. L. Radzyukevich, J. B Lingrel, and J. A. Heiny

    PNAS February 24, 2009 106 (8) 2565-2570; https://doi.org/10.1073/pnas.0804150106
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    Following movement of the L1 stalk between three functional states in single ribosomes

    Peter V. Cornish, Dmitri N. Ermolenko, David W. Staple, Lee Hoang, Robyn P. Hickerson, Harry F. Noller, and Taekjip Ha

    PNAS February 24, 2009 106 (8) 2571-2576; https://doi.org/10.1073/pnas.0813180106
  • Open Access

    Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron

    Sumit Borah, Anthony C. Wong, and Joan A. Steitz

    PNAS February 24, 2009 106 (8) 2577-2582; https://doi.org/10.1073/pnas.0812826106

• Biophysics

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    Elongation dynamics shape bursty transcription and translation

    Maciej Dobrzyński and Frank J. Bruggeman

    PNAS February 24, 2009 106 (8) 2583-2588; https://doi.org/10.1073/pnas.0803507106
  • Open Access

    Molecular simulations elucidate the substrate translocation pathway in a glutamate transporter

    Yan Gu, Indira H. Shrivastava, Susan G. Amara, and Ivet Bahar

    PNAS February 24, 2009 106 (8) 2589-2594; https://doi.org/10.1073/pnas.0812299106
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    Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group

    Woon Ki Lim, Jörg Rösgen, and S. Walter Englander

    PNAS February 24, 2009 106 (8) 2595-2600; https://doi.org/10.1073/pnas.0812588106
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    Rational stabilization of enzymes by computational redesign of surface charge–charge interactions

    Alexey V. Gribenko, Mayank M. Patel, Jiajing Liu, Scott A. McCallum, Chunyu Wang, and George I. Makhatadze

    PNAS February 24, 2009 106 (8) 2601-2606; https://doi.org/10.1073/pnas.0808220106
  • Open Access

    Identifying essential genes in Escherichia coli from a metabolic optimization principle

    Carlotta Martelli, Andrea De Martino, Enzo Marinari, Matteo Marsili, and Isaac Pérez Castillo

    PNAS February 24, 2009 106 (8) 2607-2611; https://doi.org/10.1073/pnas.0813229106
  • Open Access

    Visualizing breathing motion of internal cavities in concert with ligand migration in myoglobin

    Ayana Tomita, Tokushi Sato, Kouhei Ichiyanagi, Shunsuke Nozawa, Hirohiko Ichikawa, Matthieu Chollet, Fumihiro Kawai, Sam-Yong Park, Takayuki Tsuduki, Takahisa Yamato, Shin-ya Koshihara, and Shin-ichi Adachi

    PNAS February 24, 2009 106 (8) 2612-2616; https://doi.org/10.1073/pnas.0807774106
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    ARNT PAS-B has a fragile native state structure with an alternative β-sheet register nearby in sequence space

    Matthew R. Evans, Paul B. Card, and Kevin H. Gardner

    PNAS February 24, 2009 106 (8) 2617-2622; https://doi.org/10.1073/pnas.0808270106

• Cell Biology

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    Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

    Yu Wang, Zhe Zhou, Christopher T. Walsh, and Andrew P. McMahon

    PNAS February 24, 2009 106 (8) 2623-2628; first published February 5, 2009. https://doi.org/10.1073/pnas.0812110106
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    Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP

    Yifeng Xia, Roanna C. Padre, Tatiana Hurtado De Mendoza, Virginie Bottero, Vinay B. Tergaonkar, and Inder M. Verma

    PNAS February 24, 2009 106 (8) 2629-2634; https://doi.org/10.1073/pnas.0812256106
  • Open Access

    Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

    Jane J. Yu, Victoria A. Robb, Tasha A. Morrison, Eric A. Ariazi, Magdalena Karbowniczek, Aristotelis Astrinidis, Chunrong Wang, Lisa Hernandez-Cuebas, Laura F. Seeholzer, Emmanuelle Nicolas, Harvey Hensley, V. Craig Jordan, Cheryl L. Walker, and Elizabeth P. Henske

    PNAS February 24, 2009 106 (8) 2635-2640; https://doi.org/10.1073/pnas.0810790106
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    Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus

    Alexandros Tzatsos, Raymond Pfau, Sotirios C. Kampranis, and Philip N. Tsichlis

    PNAS February 24, 2009 106 (8) 2641-2646; https://doi.org/10.1073/pnas.0813139106
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    Stimulated nuclear translocation of NF-κB and shuttling differentially depend on dynein and the dynactin complex

    Cynthia K. Shrum, Daniel DeFrancisco, and Mollie K. Meffert

    PNAS February 24, 2009 106 (8) 2647-2652; https://doi.org/10.1073/pnas.0806677106
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    Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells

    Luiz C. Godoy, Cristina Muñoz-Pinedo, Laura Castro, Simone Cardaci, Christopher M. Schonhoff, Michael King, Verónica Tórtora, Mónica Marín, Qian Miao, Jian Fei Jiang, Alexandr Kapralov, Ronald Jemmerson, Gary G. Silkstone, Jinal N. Patel, James E. Evans, Michael T. Wilson, Douglas R. Green, Valerian E. Kagan, Rafael Radi, and Joan B. Mannick

    PNAS February 24, 2009 106 (8) 2653-2658; https://doi.org/10.1073/pnas.0809279106

• Developmental Biology

  • Open Access

    Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase

    Bernadette M. Glasheen, Aashish T. Kabra, and Andrea Page-McCaw

    PNAS February 24, 2009 106 (8) 2659-2664; https://doi.org/10.1073/pnas.0804171106

• Ecology

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    Contrasting size evolution in marine and freshwater diatoms

    E. Litchman, C. A. Klausmeier, and K. Yoshiyama

    PNAS February 24, 2009 106 (8) 2665-2670; https://doi.org/10.1073/pnas.0810891106
  • Open Access

    Culling experiments demonstrate size-class specific biomass increases with mortality

    A. Schröder, L. Persson, and A. M. de Roos

    PNAS February 24, 2009 106 (8) 2671-2676; https://doi.org/10.1073/pnas.0808279106

• Evolution

  • Open Access

    Alignment-free genome comparison with feature frequency profiles (FFP) and optimal resolutions

    Gregory E. Sims, Se-Ran Jun, Guohong A. Wu, and Sung-Hou Kim

    PNAS February 24, 2009 106 (8) 2677-2682; https://doi.org/10.1073/pnas.0813249106
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    Tri-split tRNA is a transfer RNA made from 3 transcripts that provides insight into the evolution of fragmented tRNAs in archaea

    Kosuke Fujishima, Junichi Sugahara, Kaoru Kikuta, Reiko Hirano, Asako Sato, Masaru Tomita, and Akio Kanai

    PNAS February 24, 2009 106 (8) 2683-2687; https://doi.org/10.1073/pnas.0808246106

• Genetics

  • Open Access

    Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata

    Silvia Poláková, Christian Blume, Julián Álvarez Zárate, Marek Mentel, Dorte Jørck-Ramberg, Jørgen Stenderup, and Jure Piškur

    PNAS February 24, 2009 106 (8) 2688-2693; https://doi.org/10.1073/pnas.0809793106
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    Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease

    Maria-Mercè Garcia-Barcelo, Clara Sze-man Tang, Elly Sau-wai Ngan, Vincent Chi-hang Lui, Yan Chen, Man-ting So, Thomas Yuk-yu Leon, Xiao-ping Miao, Cathy Ka-yee Shum, Feng-qin Liu, Ming-yiu Yeung, Zhen-wei Yuan, Wei-hong Guo, Lei Liu, Xiao-bing Sun, Liu-ming Huang, Jin-fa Tou, You-qiang Song, Danny Chan, Kenneth M. C. Cheung, Kenneth Kak-yuen Wong, Stacey S. Cherny, Pak-chung Sham, and Paul Kwong-hang Tam

    PNAS February 24, 2009 106 (8) 2694-2699; https://doi.org/10.1073/pnas.0809630105
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    Association of FOXO3A variation with human longevity confirmed in German centenarians

    Friederike Flachsbart, Amke Caliebe, Rabea Kleindorp, Hélène Blanché, Huberta von Eller-Eberstein, Susanna Nikolaus, Stefan Schreiber, and Almut Nebel

    PNAS February 24, 2009 106 (8) 2700-2705; https://doi.org/10.1073/pnas.0809594106

    See companion article:

    • In This Issue

      - Feb 24, 2009
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    Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function

    Amanda L. Blasius, Katharina Brandl, Karine Crozat, Yu Xia, Kevin Khovananth, Philippe Krebs, Nora G. Smart, Antonella Zampolli, Zaverio M. Ruggeri, and Bruce A. Beutler

    PNAS February 24, 2009 106 (8) 2706-2711; https://doi.org/10.1073/pnas.0813208106
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    Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

    Haihao Zhu, Jaime Acquaviva, Pranatartiharan Ramachandran, Abraham Boskovitz, Steve Woolfenden, Rolf Pfannl, Roderick T. Bronson, John W. Chen, Ralph Weissleder, David E. Housman, and Al Charest

    PNAS February 24, 2009 106 (8) 2712-2716; https://doi.org/10.1073/pnas.0813314106

• Immunology

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    Sialylated multivalent antigens engage CD22 in trans and inhibit B cell activation

    Adam H. Courtney, Erik B. Puffer, Jason K. Pontrello, Zhi-Qiang Yang, and Laura L. Kiessling

    PNAS February 24, 2009 106 (8) 2500-2505; https://doi.org/10.1073/pnas.0807207106
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    Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice

    Hwei-Ling Cheng, Bao Q. Vuong, Uttiya Basu, Andrew Franklin, Bjoern Schwer, Jillian Astarita, Ryan T. Phan, Abhishek Datta, John Manis, Frederick W. Alt, and Jayanta Chaudhuri

    PNAS February 24, 2009 106 (8) 2717-2722; https://doi.org/10.1073/pnas.0812304106
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    Perforin-mediated suppression of B-cell lymphoma

    Paul Bolitho, Shayna E. A. Street, Jennifer A. Westwood, Winfried Edelmann, Duncan MacGregor, Paul Waring, William K. Murray, Dale I. Godfrey, Joseph A. Trapani, Ricky W. Johnstone, and Mark J. Smyth

    PNAS February 24, 2009 106 (8) 2723-2728; https://doi.org/10.1073/pnas.0809008106
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    Anti-CTLA-4 therapy results in higher CD4⁺ICOS^hi T cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissues

    Hong Chen, Chrysoula I. Liakou, Ashish Kamat, Curtis Pettaway, John F. Ward, Derek Ng Tang, Jingjing Sun, Achim A. Jungbluth, Patricia Troncoso, Christopher Logothetis, and Padmanee Sharma

    PNAS February 24, 2009 106 (8) 2729-2734; https://doi.org/10.1073/pnas.0813175106
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    MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells

    Maurizio Ceppi, Patricia M. Pereira, Isabelle Dunand-Sauthier, Emmanuèle Barras, Walter Reith, Manuel A. Santos, and Philippe Pierre

    PNAS February 24, 2009 106 (8) 2735-2740; https://doi.org/10.1073/pnas.0811073106
  • Open Access

    B7-H1 (PD-L1) on T cells is required for T-cell-mediated conditioning of dendritic cell maturation

    Oezcan Talay, Ching-Hung Shen, Lieping Chen, and Jianzhu Chen

    PNAS February 24, 2009 106 (8) 2741-2746; https://doi.org/10.1073/pnas.0813367106
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    Carboxy-terminal domain of AID required for its mRNA complex formation in vivo

    Taichiro Nonaka, Tomomitsu Doi, Takae Toyoshima, Masamichi Muramatsu, Tasuku Honjo, and Kazuo Kinoshita

    PNAS February 24, 2009 106 (8) 2747-2751; https://doi.org/10.1073/pnas.0812957106
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    Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination

    Nasim A. Begum, Andre Stanlie, Tomomitsu Doi, Yoko Sasaki, Hai Wei Jin, Yong Sung Kim, Hitoshi Nagaoka, and Tasuku Honjo

    PNAS February 24, 2009 106 (8) 2752-2757; https://doi.org/10.1073/pnas.0813252106
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    The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

    Tomomitsu Doi, Lucia Kato, Satomi Ito, Reiko Shinkura, Min Wei, Hitoshi Nagaoka, Jishu Wang, and Tasuku Honjo

    PNAS February 24, 2009 106 (8) 2758-2763; https://doi.org/10.1073/pnas.0813253106
  • Open Access

    Prevention of autoimmune disease by induction of tolerance to Toll-like receptor 7

    Tomoko Hayashi, Christine S. Gray, Michael Chan, Rommel I. Tawatao, Lisa Ronacher, Maureen A. McGargill, Sandip K. Datta, Dennis A. Carson, and Maripat Corr

    PNAS February 24, 2009 106 (8) 2764-2769; https://doi.org/10.1073/pnas.0813037106
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    Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

    Michal Caspi Tal, Miwa Sasai, Heung Kyu Lee, Brian Yordy, Gerald S. Shadel, and Akiko Iwasaki

    PNAS February 24, 2009 106 (8) 2770-2775; https://doi.org/10.1073/pnas.0807694106
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    Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes

    Jan Petersen, Stephanie J. Wurzbacher, Nicholas A. Williamson, Sri H. Ramarathinam, Hugh H. Reid, Ashish K. N. Nair, Anne Y. Zhao, Roza Nastovska, Geordie Rudge, Jamie Rossjohn, and Anthony W. Purcell

    PNAS February 24, 2009 106 (8) 2776-2781; https://doi.org/10.1073/pnas.0812901106
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    The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response

    Jennifer R. Powell, Dennis H. Kim, and Frederick M. Ausubel

    PNAS February 24, 2009 106 (8) 2782-2787; https://doi.org/10.1073/pnas.0813048106
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    Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in mice

    Héctor Pérez Montoyo, Carlos Vaccaro, Martin Hafner, Raimund J. Ober, Werner Mueller, and E. Sally Ward

    PNAS February 24, 2009 106 (8) 2788-2793; https://doi.org/10.1073/pnas.0810796106

• Medical Sciences

  • Open Access

    Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis

    Tomoyuki Awano, Gary S. Johnson, Claire M. Wade, Martin L. Katz, Gayle C. Johnson, Jeremy F. Taylor, Michele Perloski, Tara Biagi, Izabella Baranowska, Sam Long, Philip A. March, Natasha J. Olby, G. Diane Shelton, Shahnawaz Khan, Dennis P. O'Brien, Kerstin Lindblad-Toh, and Joan R. Coates

    PNAS February 24, 2009 106 (8) 2794-2799; https://doi.org/10.1073/pnas.0812297106

    See companion article:

    • In This Issue

      - Feb 24, 2009
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    Anti-laminin gamma-1 pemphigoid

    Teruki Dainichi, Sadamu Kurono, Bungo Ohyama, Norito Ishii, Noriko Sanzen, Maria Hayashi, Chisei Shimono, Yukimasa Taniguchi, Hiroshi Koga, Tadashi Karashima, Shinichiro Yasumoto, Detlef Zillikens, Kiyotoshi Sekiguchi, and Takashi Hashimoto

    PNAS February 24, 2009 106 (8) 2800-2805; https://doi.org/10.1073/pnas.0809230106
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    β-Arrestin links endothelin A receptor to β-catenin signaling to induce ovarian cancer cell invasion and metastasis

    Laura Rosanò, Roberta Cianfrocca, Stefano Masi, Francesca Spinella, Valeriana Di Castro, Annamaria Biroccio, Erica Salvati, Maria Rita Nicotra, Pier Giorgio Natali, and Anna Bagnato

    PNAS February 24, 2009 106 (8) 2806-2811; https://doi.org/10.1073/pnas.0807158106
  • Open Access

    The miR-17∼92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma

    Tamar Uziel, Fedor V. Karginov, Suqing Xie, Joel S. Parker, Yong-Dong Wang, Amar Gajjar, Lin He, David Ellison, Richard J. Gilbertson, Gregory Hannon, and Martine F. Roussel

    PNAS February 24, 2009 106 (8) 2812-2817; https://doi.org/10.1073/pnas.0809579106
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    Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

    Leah E. Cowen, Sheena D. Singh, Julia R. Köhler, Cathy Collins, Aimee K. Zaas, Wiley A. Schell, Hamza Aziz, Eleftherios Mylonakis, John R. Perfect, Luke Whitesell, and Susan Lindquist

    PNAS February 24, 2009 106 (8) 2818-2823; https://doi.org/10.1073/pnas.0813394106

    See companion article:

    • Dynamic duo takes down fungal villains

      - Mar 03, 2009
  • Open Access

    Prognostic gene signatures for non-small-cell lung cancer

    Paul C. Boutros, Suzanne K. Lau, Melania Pintilie, Ni Liu, Frances A. Shepherd, Sandy D. Der, Ming-Sound Tsao, Linda Z. Penn, and Igor Jurisica

    PNAS February 24, 2009 106 (8) 2824-2828; https://doi.org/10.1073/pnas.0809444106
  • Open Access

    Potassium softens vascular endothelium and increases nitric oxide release

    H. Oberleithner, C. Callies, K. Kusche-Vihrog, H. Schillers, V. Shahin, C. Riethmüller, G. A. MacGregor, and H. E. de Wardener

    PNAS February 24, 2009 106 (8) 2829-2834; https://doi.org/10.1073/pnas.0813069106
  • Open Access

    Knockin of mutant PIK3CA activates multiple oncogenic pathways

    John P. Gustin, Bedri Karakas, Michele B. Weiss, Abde M. Abukhdeir, Josh Lauring, Joseph P. Garay, David Cosgrove, Akina Tamaki, Hiroyuki Konishi, Yuko Konishi, Morassa Mohseni, Grace Wang, D. Marc Rosen, Samuel R. Denmeade, Michaela J. Higgins, Michele I. Vitolo, Kurtis E. Bachman, and Ben Ho Park

    PNAS February 24, 2009 106 (8) 2835-2840; https://doi.org/10.1073/pnas.0813351106
  • Open Access

    Loss of cryptochrome reduces cancer risk in p53 mutant mice

    Nuri Ozturk, Jin Hyup Lee, Shobhan Gaddameedhi, and Aziz Sancar

    PNAS February 24, 2009 106 (8) 2841-2846; https://doi.org/10.1073/pnas.0813028106
  • Open Access

    Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography

    Rachel E. Laing, Martin A. Walter, Dean O. Campbell, Harvey R. Herschman, Nagichettiar Satyamurthy, Michael E. Phelps, Johannes Czernin, Owen N. Witte, and Caius G. Radu

    PNAS February 24, 2009 106 (8) 2847-2852; https://doi.org/10.1073/pnas.0812890106
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    Transforming activity of AML1-ETO is independent of CBFβ and ETO interaction but requires formation of homo-oligomeric complexes

    Colin Kwok, Bernd B. Zeisig, Jihui Qiu, Shuo Dong, and Chi Wai Eric So

    PNAS February 24, 2009 106 (8) 2853-2858; https://doi.org/10.1073/pnas.0810558106
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    A role for epithelial-mesenchymal transition in the etiology of benign prostatic hyperplasia

    Paloma Alonso-Magdalena, Clemens Brössner, Angelika Reiner, Guojun Cheng, Nobuhiro Sugiyama, Margaret Warner, and Jan-Åke Gustafsson

    PNAS February 24, 2009 106 (8) 2859-2863; https://doi.org/10.1073/pnas.0812666106
  • Open Access

    Circadian oscillation of nucleotide excision repair in mammalian brain

    • From the Cover

    Tae-Hong Kang, Joyce T. Reardon, Michael Kemp, and Aziz Sancar

    PNAS February 24, 2009 106 (8) 2864-2867; https://doi.org/10.1073/pnas.0812638106

    See companion article:

    • It's all in a day's work: Regulation of DNA excision repair by the circadian clock

      - Feb 24, 2009
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    Vpu enhances HIV-1 virus release in the absence of Bst-2 cell surface down-modulation and intracellular depletion

    Eri Miyagi, Amy J. Andrew, Sandra Kao, and Klaus Strebel

    PNAS February 24, 2009 106 (8) 2868-2873; https://doi.org/10.1073/pnas.0813223106

• Microbiology

  • Open Access

    Genomic reconstruction of Shewanella oneidensis MR-1 metabolism reveals a previously uncharacterized machinery for lactate utilization

    Grigory E. Pinchuk, Dmitry A. Rodionov, Chen Yang, Xiaoqing Li, Andrei L. Osterman, Etienne Dervyn, Oleg V. Geydebrekht, Samantha B. Reed, Margaret F. Romine, Frank R. Collart, James H. Scott, Jim K. Fredrickson, and Alexander S. Beliaev

    PNAS February 24, 2009 106 (8) 2874-2879; https://doi.org/10.1073/pnas.0806798106
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    Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B

    Marija Backovic, Richard Longnecker, and Theodore S. Jardetzky

    PNAS February 24, 2009 106 (8) 2880-2885; https://doi.org/10.1073/pnas.0810530106
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    Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein

    Rachel L. Kaletsky, Joseph R. Francica, Caroline Agrawal-Gamse, and Paul Bates

    PNAS February 24, 2009 106 (8) 2886-2891; https://doi.org/10.1073/pnas.0811014106

• Neuroscience

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    Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: Involvement of the circadian pacemaker

    Kun Hu, Eus J. W. Van Someren, Steven A. Shea, and Frank A. J. L. Scheer

    PNAS February 24, 2009 106 (8) 2490-2494; https://doi.org/10.1073/pnas.0806087106
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    Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

    Jill R. Crittenden, Ippolita Cantuti-Castelvetri, Esen Saka, Christine E. Keller-McGandy, Ledia F. Hernandez, Lauren R. Kett, Anne B. Young, David G. Standaert, and Ann M. Graybiel

    PNAS February 24, 2009 106 (8) 2892-2896; https://doi.org/10.1073/pnas.0812822106

    See companion article:

    • Levodopa-induced dyskinesia and striatal signaling pathways

      - Mar 03, 2009
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    CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

    Han Seok Ko, Rachel Bailey, Wanli W. Smith, Zhaohui Liu, Joo-Ho Shin, Yun-Il Lee, Yong-Jie Zhang, Haibing Jiang, Christopher A. Ross, Darren J. Moore, Cam Patterson, Leonard Petrucelli, Ted M. Dawson, and Valina L. Dawson

    PNAS February 24, 2009 106 (8) 2897-2902; https://doi.org/10.1073/pnas.0810123106
  • Open Access

    Discovery of a functional protein complex of netrin-4, laminin γ1 chain, and integrin α6β1 in mouse neural stem cells

    Fernanda I. Staquicini, Emmanuel Dias-Neto, Jianxue Li, Evan Y. Snyder, Richard L. Sidman, Renata Pasqualini, and Wadih Arap

    PNAS February 24, 2009 106 (8) 2903-2908; https://doi.org/10.1073/pnas.0813286106
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    TOX3 regulates calcium-dependent transcription in neurons

    Shauna H. Yuan, Zilong Qiu, and Anirvan Ghosh

    PNAS February 24, 2009 106 (8) 2909-2914; https://doi.org/10.1073/pnas.0805555106
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    Methylphenidate-induced dendritic spine formation and ΔFosB expression in nucleus accumbens

    Yong Kim, Merilee A. Teylan, Matthew Baron, Adam Sands, Angus C. Nairn, and Paul Greengard

    PNAS February 24, 2009 106 (8) 2915-2920; https://doi.org/10.1073/pnas.0813179106
  • Open Access

    Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition

    Asif K. Mustafa, Damian B. van Rossum, Randen L. Patterson, David Maag, Jeffrey T. Ehmsen, Sadia K. Gazi, Anutosh Chakraborty, Roxanne K. Barrow, L. Mario Amzel, and Solomon H. Snyder

    PNAS February 24, 2009 106 (8) 2921-2926; https://doi.org/10.1073/pnas.0813105106
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    Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi

    Christina Dalla, Efstathios B. Papachristos, Abigail S. Whetstone, and Tracey J. Shors

    PNAS February 24, 2009 106 (8) 2927-2932; https://doi.org/10.1073/pnas.0809650106
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    Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

    Pei-Chun Chen, Marcelo R. Vargas, Amar K. Pani, Richard J. Smeyne, Delinda A. Johnson, Yuet Wai Kan, and Jeffrey A. Johnson

    PNAS February 24, 2009 106 (8) 2933-2938; https://doi.org/10.1073/pnas.0813361106
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    Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations

    Jonathan E. Rubin, John A. Hayes, Jeffrey L. Mendenhall, and Christopher A. Del Negro

    PNAS February 24, 2009 106 (8) 2939-2944; https://doi.org/10.1073/pnas.0808776106
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    Counting the number of releasable synaptic vesicles in a presynaptic terminal

    Kaori Ikeda and John M. Bekkers

    PNAS February 24, 2009 106 (8) 2945-2950; https://doi.org/10.1073/pnas.0811017106
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    DSCAM functions as a netrin receptor in commissural axon pathfinding

    Guofa Liu, Weiquan Li, Lei Wang, Amar Kar, Kun-Liang Guan, Yi Rao, and Jane Y. Wu

    PNAS February 24, 2009 106 (8) 2951-2956; https://doi.org/10.1073/pnas.0811083106

• Physiology

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    An oxygen-sensitive mechanism in regulation of epithelial sodium channel

    Su Wang, Stephen Publicover, and Yuchun Gu

    PNAS February 24, 2009 106 (8) 2957-2962; https://doi.org/10.1073/pnas.0809100106

• Psychology

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    Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1

    Elizabeth A. Shirtcliff, Christopher L. Coe, and Seth D. Pollak

    PNAS February 24, 2009 106 (8) 2963-2967; https://doi.org/10.1073/pnas.0806660106