Table of Contents

Biological Sciences

• Applied Biological Sciences

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    Supramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitus

    Sarika Gupta, Tandrika Chattopadhyay, Mahendra Pal Singh, and Avadhesha Surolia

    PNAS July 27, 2010 107 (30) 13246-13251; https://doi.org/10.1073/pnas.1005704107
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    Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

    Jamie B. Spangler, Jason R. Neil, Sivan Abramovitch, Yosef Yarden, Forest M. White, Douglas A. Lauffenburger, and K. Dane Wittrup

    PNAS July 27, 2010 107 (30) 13252-13257; https://doi.org/10.1073/pnas.0913476107
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    High-throughput engineering and analysis of peptide binding to class II MHC

    Wei Jiang and Eric T. Boder

    PNAS July 27, 2010 107 (30) 13258-13263; https://doi.org/10.1073/pnas.1006344107

• Biochemistry

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    Tunable recognition of the steroid α-face by adjacent π-electron density

    T. Friščić, R. W. Lancaster, L. Fábián, and P. G. Karamertzanis

    PNAS July 27, 2010 107 (30) 13216-13221; https://doi.org/10.1073/pnas.0915142107
  • Open Access

    Structural basis for agonism and antagonism of hepatocyte growth factor

    W. David Tolbert, Jennifer Daugherty-Holtrop, Ermanno Gherardi, George Vande Woude, and H. Eric Xu

    PNAS July 27, 2010 107 (30) 13264-13269; https://doi.org/10.1073/pnas.1005183107
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    Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA

    Bjorn Vergauwen, Jonathan Elegheert, Ann Dansercoer, Bart Devreese, and Savvas N. Savvides

    PNAS July 27, 2010 107 (30) 13270-13275; https://doi.org/10.1073/pnas.1005198107

• Biophysics and Computational Biology

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    Spectroscopic elucidation of uncoupled transition energies in the major photosynthetic light-harvesting complex, LHCII

    Gabriela S. Schlau-Cohen, Tessa R. Calhoun, Naomi S. Ginsberg, Matteo Ballottari, Roberto Bassi, and Graham R. Fleming

    PNAS July 27, 2010 107 (30) 13276-13281; https://doi.org/10.1073/pnas.1006230107
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    Phase behavior of mixtures of human lens proteins Gamma D and Beta B1

    Ying Wang, Aleksey Lomakin, Jennifer J. McManus, Olutayo Ogun, and George B. Benedek

    PNAS July 27, 2010 107 (30) 13282-13287; https://doi.org/10.1073/pnas.1008353107
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    Sum frequency generation and solid-state NMR study of the structure, orientation, and dynamics of polystyrene-adsorbed peptides

    Tobias Weidner, Nicholas F. Breen, Kun Li, Gary P. Drobny, and David G. Castner

    PNAS July 27, 2010 107 (30) 13288-13293; https://doi.org/10.1073/pnas.1003832107
  • Open Access

    Single-molecule denaturation mapping of DNA in nanofluidic channels

    Walter Reisner, Niels B. Larsen, Asli Silahtaroglu, Anders Kristensen, Niels Tommerup, Jonas O. Tegenfeldt, and Henrik Flyvbjerg

    PNAS July 27, 2010 107 (30) 13294-13299; https://doi.org/10.1073/pnas.1007081107
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    Biological role of noise encoded in a genetic network motif

    • From the Cover

    Mark Kittisopikul and Gürol M. Süel

    PNAS July 27, 2010 107 (30) 13300-13305; https://doi.org/10.1073/pnas.1003975107
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    Cooperative formation of native-like tertiary contacts in the ensemble of unfolded states of a four-helix protein

    Susanne W. Bruun, Vytautas Iešmantavičius, Jens Danielsson, and Flemming M. Poulsen

    PNAS July 27, 2010 107 (30) 13306-13311; https://doi.org/10.1073/pnas.1003004107

• Cell Biology

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    Phosphorylation stabilizes Nanog by promoting its interaction with Pin1

    Matteo Moretto-Zita, Hua Jin, Zhouxin Shen, Tongbiao Zhao, Steven P. Briggs, and Yang Xu

    PNAS July 27, 2010 107 (30) 13312-13317; https://doi.org/10.1073/pnas.1005847107
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    ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

    Shuo-Chien Ling, Claudio P. Albuquerque, Joo Seok Han, Clotilde Lagier-Tourenne, Seiya Tokunaga, Huilin Zhou, and Don W. Cleveland

    PNAS July 27, 2010 107 (30) 13318-13323; https://doi.org/10.1073/pnas.1008227107
  • Open Access

    Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions

    • From the Cover

    Nicolas Borghi, Molly Lowndes, Venkat Maruthamuthu, Margaret L. Gardel, and W. James Nelson

    PNAS July 27, 2010 107 (30) 13324-13329; first published June 21, 2010. https://doi.org/10.1073/pnas.1002662107
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    A non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeast

    Qi Gao, Thibault Courtheoux, Yannick Gachet, Sylvie Tournier, and Xiangwei He

    PNAS July 27, 2010 107 (30) 13330-13335; https://doi.org/10.1073/pnas.1004887107
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    3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

    • From the Cover

    Richard L. Felts, Kedar Narayan, Jacob D. Estes, Dan Shi, Charles M. Trubey, Jing Fu, Lisa M. Hartnell, Gordon T. Ruthel, Douglas K. Schneider, Kunio Nagashima, Julian W. Bess Jr., Sina Bavari, Bradley C. Lowekamp, Donald Bliss, Jeffrey D. Lifson, and Sriram Subramaniam

    PNAS July 27, 2010 107 (30) 13336-13341; https://doi.org/10.1073/pnas.1003040107
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    Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery

    Anders Wittrup, Si-He Zhang, Katrin J. Svensson, Paulina Kucharzewska, Maria C. Johansson, Matthias Mörgelin, and Mattias Belting

    PNAS July 27, 2010 107 (30) 13342-13347; https://doi.org/10.1073/pnas.1002622107
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    Metacaspase Yca1 is required for clearance of insoluble protein aggregates

    Robin E. C. Lee, Steve Brunette, Lawrence G. Puente, and Lynn A. Megeney

    PNAS July 27, 2010 107 (30) 13348-13353; https://doi.org/10.1073/pnas.1006610107

• Developmental Biology

  • Open Access

    Automated vocal analysis of naturalistic recordings from children with autism, language delay, and typical development

    D. K. Oller, P. Niyogi, S. Gray, J. A. Richards, J. Gilkerson, D. Xu, U. Yapanel, and S. F. Warren

    PNAS July 27, 2010 107 (30) 13354-13359; https://doi.org/10.1073/pnas.1003882107
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    Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis

    Mark W. Murphy, Aaron L. Sarver, Daren Rice, Katerina Hatzi, Kenny Ye, Ari Melnick, Leslie L. Heckert, David Zarkower, and Vivian J. Bardwell

    PNAS July 27, 2010 107 (30) 13360-13365; https://doi.org/10.1073/pnas.1006243107
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    Maturation of the olfactory sensory neurons by Apaf-1/caspase-9–mediated caspase activity

    Shizue Ohsawa, Shun Hamada, Keisuke Kuida, Hiroki Yoshida, Tatsushi Igaki, and Masayuki Miura

    PNAS July 27, 2010 107 (30) 13366-13371; https://doi.org/10.1073/pnas.0910488107

• Environmental Sciences

  • Open Access

    Control of transpiration by radiation

    Roland Pieruschka, Gregor Huber, and Joseph A. Berry

    PNAS July 27, 2010 107 (30) 13372-13377; https://doi.org/10.1073/pnas.0913177107

• Evolution

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    Origin of a function by tandem gene duplication limits the evolutionary capability of its sister copy

    Martin Hasselmann, Sarah Lechner, Christina Schulte, and Martin Beye

    PNAS July 27, 2010 107 (30) 13378-13383; https://doi.org/10.1073/pnas.1005617107

• Genetics

  • Open Access

    PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance

    Johanna M. M. van Oers, Sergio Roa, Uwe Werling, Yiyong Liu, Jochen Genschel, Harry Hou Jr., Rani S. Sellers, Paul Modrich, Matthew D. Scharff, and Winfried Edelmann

    PNAS July 27, 2010 107 (30) 13384-13389; https://doi.org/10.1073/pnas.1008589107
  • Open Access

    DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

    Fanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc, Elena Lam, Eddy Magdeleine, Thomas Filleron, Naïma Oumouhou, Bernd Kaina, Mineaki Seki, Fanny Grimal, Magali Lacroix-Triki, Alastair Thompson, Henri Roché, Jean-Christophe Bourdon, Richard D. Wood, Jean-Sébastien Hoffmann, and Christophe Cazaux

    PNAS July 27, 2010 107 (30) 13390-13395; https://doi.org/10.1073/pnas.0910759107
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    Increased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in Drosophila

    Cynthia J. Schoen, Sarah B. Emery, Marc C. Thorne, Hima R. Ammana, Elżbieta Śliwerska, Jameson Arnett, Michael Hortsch, Frances Hannan, Margit Burmeister, and Marci M. Lesperance

    PNAS July 27, 2010 107 (30) 13396-13401; https://doi.org/10.1073/pnas.1003027107

• Immunology

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    Programmed death-1 (PD-1)–deficient mice are extraordinarily sensitive to tuberculosis

    Eszter Lázár-Molnár, Bing Chen, Kari A. Sweeney, Emilie J. Wang, Weijun Liu, Juan Lin, Steven A. Porcelli, Steven C. Almo, Stanley G. Nathenson, and William R. Jacobs Jr.

    PNAS July 27, 2010 107 (30) 13402-13407; https://doi.org/10.1073/pnas.1007394107
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    A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey

    Lu Deng, C. Alejandro Velikovsky, Gang Xu, Lakshminarayan M. Iyer, Satoshi Tasumi, Melissa C. Kerzic, Martin F. Flajnik, L. Aravind, Zeev Pancer, and Roy A. Mariuzza

    PNAS July 27, 2010 107 (30) 13408-13413; https://doi.org/10.1073/pnas.1005475107
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    EphB–ephrin-B2 interactions are required for thymus migration during organogenesis

    Katie E. Foster, Julie Gordon, Kim Cardenas, Henrique Veiga-Fernandes, Taija Makinen, Elena Grigorieva, David G. Wilkinson, C. Clare Blackburn, Ellen Richie, Nancy R. Manley, Ralf H. Adams, Dimitris Kioussis, and Mark C. Coles

    PNAS July 27, 2010 107 (30) 13414-13419; https://doi.org/10.1073/pnas.1003747107

• Medical Sciences

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    Topological optimization for designing patient-specific large craniofacial segmental bone replacements

    Alok Sutradhar, Glaucio H. Paulino, Michael J. Miller, and Tam H. Nguyen

    PNAS July 27, 2010 107 (30) 13222-13227; https://doi.org/10.1073/pnas.1001208107
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    Mammalian life-span determinant p66^shcA mediates obesity-induced insulin resistance

    Sofia Chiatamone Ranieri, Salvatore Fusco, Emiliano Panieri, Valentina Labate, Marina Mele, Valentina Tesori, Anna Maria Ferrara, Giuseppe Maulucci, Marco De Spirito, Giuseppe Ettore Martorana, Tommaso Galeotti, and Giovambattista Pani

    PNAS July 27, 2010 107 (30) 13420-13425; https://doi.org/10.1073/pnas.1008647107
  • Open Access

    Reversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic β-like cells

    Zaida Alipio, Wenbin Liao, Elizabeth J. Roemer, Milton Waner, Louis M. Fink, David C. Ward, and Yupo Ma

    PNAS July 27, 2010 107 (30) 13426-13431; https://doi.org/10.1073/pnas.1007884107
  • Open Access

    Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

    Jynho Kim, John J. Lee, James Kim, Dale Gardner, and Philip A. Beachy

    PNAS July 27, 2010 107 (30) 13432-13437; https://doi.org/10.1073/pnas.1006822107
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    Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

    Pawel K. Mazur, Henrik Einwächter, Marcel Lee, Bence Sipos, Hassan Nakhai, Roland Rad, Ursula Zimber-Strobl, Lothar J. Strobl, Freddy Radtke, Günter Klöppel, Roland M. Schmid, and Jens T. Siveke

    PNAS July 27, 2010 107 (30) 13438-13443; https://doi.org/10.1073/pnas.1002423107
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    E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation

    Yi Yang, HanhChi Do, Xuejun Tian, Chaozheng Zhang, Xinyuan Liu, Laura A. Dada, Jacob I. Sznajder, and Jing Liu

    PNAS July 27, 2010 107 (30) 13444-13449; https://doi.org/10.1073/pnas.0913690107
  • Open Access

    MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro

    Yun Fang, Congzhu Shi, Elisabetta Manduchi, Mete Civelek, and Peter F. Davies

    PNAS July 27, 2010 107 (30) 13450-13455; https://doi.org/10.1073/pnas.1002120107

• Microbiology

  • Open Access

    Essential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccines

    Barry N. Duplantis, Milan Osusky, Crystal L. Schmerk, Darrell R. Ross, Catharine M. Bosio, and Francis E. Nano

    PNAS July 27, 2010 107 (30) 13456-13460; first published July 12, 2010. https://doi.org/10.1073/pnas.1004119107
  • Open Access

    Microbisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetes

    Lucy C. Foulston and Mervyn J. Bibb

    PNAS July 27, 2010 107 (30) 13461-13466; https://doi.org/10.1073/pnas.1008285107
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    Structural organization of the functional domains of Clostridium difficile toxins A and B

    Rory N. Pruitt, Melissa G. Chambers, Kenneth K.-S. Ng, Melanie D. Ohi, and D. Borden Lacy

    PNAS July 27, 2010 107 (30) 13467-13472; https://doi.org/10.1073/pnas.1002199107
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    Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin–mediated cellular injury

    Georgia A. Wilke and Juliane Bubeck Wardenburg

    PNAS July 27, 2010 107 (30) 13473-13478; https://doi.org/10.1073/pnas.1001815107
  • Open Access

    A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria

    Sebastian Lücker, Michael Wagner, Frank Maixner, Eric Pelletier, Hanna Koch, Benoit Vacherie, Thomas Rattei, Jaap S. Sinninghe Damsté, Eva Spieck, Denis Le Paslier, and Holger Daims

    PNAS July 27, 2010 107 (30) 13479-13484; https://doi.org/10.1073/pnas.1003860107

• Neuroscience

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    Cortical and subcortical interactions during action reprogramming and their related white matter pathways

    Franz-Xaver Neubert, Rogier B. Mars, Ethan R. Buch, Etienne Olivier, and Matthew F. S. Rushworth

    PNAS July 27, 2010 107 (30) 13240-13245; https://doi.org/10.1073/pnas.1000674107
  • Open Access

    Network architecture of the long-distance pathways in the macaque brain

    Dharmendra S. Modha and Raghavendra Singh

    PNAS July 27, 2010 107 (30) 13485-13490; https://doi.org/10.1073/pnas.1008054107
  • Open Access

    Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning

    Jones G. Parker, Larry S. Zweifel, Jeremy J. Clark, Scott B. Evans, Paul E. M. Phillips, and Richard D. Palmiter

    PNAS July 27, 2010 107 (30) 13491-13496; https://doi.org/10.1073/pnas.1007827107
  • Open Access

    Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila

    Elzbieta Kula-Eversole, Emi Nagoshi, Yuhua Shang, Joseph Rodriguez, Ravi Allada, and Michael Rosbash

    PNAS July 27, 2010 107 (30) 13497-13502; https://doi.org/10.1073/pnas.1002081107
  • Open Access

    Learning-dependent plasticity with and without training in the human brain

    Jiaxiang Zhang and Zoe Kourtzi

    PNAS July 27, 2010 107 (30) 13503-13508; https://doi.org/10.1073/pnas.1002506107
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    A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction

    L. Elliot Hong, Colin A. Hodgkinson, Yihong Yang, Hemalatha Sampath, Thomas J. Ross, Brittany Buchholz, Betty Jo Salmeron, Vibhuti Srivastava, Gunvant K. Thaker, David Goldman, and Elliot A. Stein

    PNAS July 27, 2010 107 (30) 13509-13514; https://doi.org/10.1073/pnas.1004745107
  • Open Access

    TGF-β2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal size

    Sitt Wai Fong, Ian S. McLennan, Andrew McIntyre, Jayne Reid, Kathleen I. J. Shennan, and Guy S. Bewick

    PNAS July 27, 2010 107 (30) 13515-13519; https://doi.org/10.1073/pnas.1001695107

• Pharmacology

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    Nicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH

    • From the Cover
    • Inaugural Article

    Angela P. Blum, Henry A. Lester, and Dennis A. Dougherty

    PNAS July 27, 2010 107 (30) 13206-13211; https://doi.org/10.1073/pnas.1007140107
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    Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands

    Philippe de Medina, Michael R. Paillasse, Gregory Segala, Marc Poirot, and Sandrine Silvente-Poirot

    PNAS July 27, 2010 107 (30) 13520-13525; https://doi.org/10.1073/pnas.1002922107

• Physiology

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    Tissue kallikrein permits early renal adaptation to potassium load

    Soumaya El Moghrabi, Pascal Houillier, Nicolas Picard, Fabien Sohet, Bharath Wootla, May Bloch-Faure, Françoise Leviel, Lydie Cheval, Sebastian Frische, Pierre Meneton, Dominique Eladari, and Régine Chambrey

    PNAS July 27, 2010 107 (30) 13526-13531; https://doi.org/10.1073/pnas.0913070107

• Plant Biology

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    Divergent metabolome and proteome suggest functional independence of dual phloem transport systems in cucurbits

    • From the Cover

    Baichen Zhang, Vladimir Tolstikov, Colin Turnbull, Leslie M. Hicks, and Oliver Fiehn

    PNAS July 27, 2010 107 (30) 13532-13537; https://doi.org/10.1073/pnas.0910558107
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    Cryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligase

    Rae-Dong Jeong, A. C. Chandra-Shekara, Subhankar Roy Barman, Duroy Navarre, Daniel F. Klessig, Aardra Kachroo, and Pradeep Kachroo

    PNAS July 27, 2010 107 (30) 13538-13543; https://doi.org/10.1073/pnas.1004529107
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    A unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogens

    Justin D. Faris, Zengcui Zhang, Huangjun Lu, Shunwen Lu, Leela Reddy, Sylvie Cloutier, John P. Fellers, Steven W. Meinhardt, Jack B. Rasmussen, Steven S. Xu, Richard P. Oliver, Kristin J. Simons, and Timothy L. Friesen

    PNAS July 27, 2010 107 (30) 13544-13549; https://doi.org/10.1073/pnas.1004090107

• Systems Biology

  • Open Access

    Fourier analysis and systems identification of the p53 feedback loop

    Naama Geva-Zatorsky, Erez Dekel, Eric Batchelor, Galit Lahav, and Uri Alon

    PNAS July 27, 2010 107 (30) 13550-13555; https://doi.org/10.1073/pnas.1001107107