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Table of Contents
July 27, 2010; vol. 107 no. 30
This Week in PNAS
Letters (Online Only)
- You have accessEvolution, design, and genomic suboptimality: Does science “save theology”?Michael J. Murray and Jeffrey P. Schloss
Profile
Physical Sciences
Applied Physical Sciences
- You have accessOrdering dynamics of blue phases entails kinetic stabilization of amorphous networksOliver Henrich, Kevin Stratford, Davide Marenduzzo, and Michael E. Cates
Chemistry
- You have accessNicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH
- From the Cover
- Inaugural Article
Angela P. Blum, Henry A. Lester, and Dennis A. DoughertySee companion article:
- Defining the determinants of nicotine selectivity- Jul 19, 2010
- You have accessTunable recognition of the steroid α-face by adjacent π-electron densityT. Friščić, R. W. Lancaster, L. Fábián, and P. G. Karamertzanis
- You have accessSpectroscopic elucidation of uncoupled transition energies in the major photosynthetic light-harvesting complex, LHCIIGabriela S. Schlau-Cohen, Tessa R. Calhoun, Naomi S. Ginsberg, Matteo Ballottari, Roberto Bassi, and Graham R. Fleming
- You have accessPhase behavior of mixtures of human lens proteins Gamma D and Beta B1Ying Wang, Aleksey Lomakin, Jennifer J. McManus, Olutayo Ogun, and George B. Benedek
- You have accessSum frequency generation and solid-state NMR study of the structure, orientation, and dynamics of polystyrene-adsorbed peptidesTobias Weidner, Nicholas F. Breen, Kun Li, Gary P. Drobny, and David G. Castner
Engineering
- You have accessTopological optimization for designing patient-specific large craniofacial segmental bone replacementsAlok Sutradhar, Glaucio H. Paulino, Michael J. Miller, and Tam H. Nguyen
Environmental Sciences
- Open AccessControl of transpiration by radiationRoland Pieruschka, Gregor Huber, and Joseph A. Berry
- Open AccessEssential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccinesBarry N. Duplantis, Milan Osusky, Crystal L. Schmerk, Darrell R. Ross, Catharine M. Bosio, and Francis E. NanoPNAS July 27, 2010 107 (30) 13456-13460; first published July 12, 2010. https://doi.org/10.1073/pnas.1004119107
Physics
- You have accessAging and nonergodicity beyond the Khinchin theoremS. Burov, R. Metzler, and E. Barkai
Social Sciences
Anthropology
- You have accessRapid evolution of ritual architecture in central Polynesia indicated by precise 230Th/U coral datingWarren D. Sharp, Jennifer G. Kahn, Christina M. Polito, and Patrick V. Kirch
Psychological and Cognitive Sciences
- You have accessCortical and subcortical interactions during action reprogramming and their related white matter pathwaysFranz-Xaver Neubert, Rogier B. Mars, Ethan R. Buch, Etienne Olivier, and Matthew F. S. Rushworth
- Open AccessAutomated vocal analysis of naturalistic recordings from children with autism, language delay, and typical developmentD. K. Oller, P. Niyogi, S. Gray, J. A. Richards, J. Gilkerson, D. Xu, U. Yapanel, and S. F. Warren
Biological Sciences
Applied Biological Sciences
- You have accessSupramolecular insulin assembly II for a sustained treatment of type 1 diabetes mellitusSarika Gupta, Tandrika Chattopadhyay, Mahendra Pal Singh, and Avadhesha Surolia
- You have accessCombination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recyclingJamie B. Spangler, Jason R. Neil, Sivan Abramovitch, Yosef Yarden, Forest M. White, Douglas A. Lauffenburger, and K. Dane Wittrup
- You have accessHigh-throughput engineering and analysis of peptide binding to class II MHCWei Jiang and Eric T. Boder
Biochemistry
- You have accessTunable recognition of the steroid α-face by adjacent π-electron densityT. Friščić, R. W. Lancaster, L. Fábián, and P. G. Karamertzanis
- Open AccessStructural basis for agonism and antagonism of hepatocyte growth factorW. David Tolbert, Jennifer Daugherty-Holtrop, Ermanno Gherardi, George Vande Woude, and H. Eric Xu
- You have accessGlutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpABjorn Vergauwen, Jonathan Elegheert, Ann Dansercoer, Bart Devreese, and Savvas N. Savvides
Biophysics and Computational Biology
- You have accessSpectroscopic elucidation of uncoupled transition energies in the major photosynthetic light-harvesting complex, LHCIIGabriela S. Schlau-Cohen, Tessa R. Calhoun, Naomi S. Ginsberg, Matteo Ballottari, Roberto Bassi, and Graham R. Fleming
- You have accessPhase behavior of mixtures of human lens proteins Gamma D and Beta B1Ying Wang, Aleksey Lomakin, Jennifer J. McManus, Olutayo Ogun, and George B. Benedek
- You have accessSum frequency generation and solid-state NMR study of the structure, orientation, and dynamics of polystyrene-adsorbed peptidesTobias Weidner, Nicholas F. Breen, Kun Li, Gary P. Drobny, and David G. Castner
- Open AccessSingle-molecule denaturation mapping of DNA in nanofluidic channelsWalter Reisner, Niels B. Larsen, Asli Silahtaroglu, Anders Kristensen, Niels Tommerup, Jonas O. Tegenfeldt, and Henrik Flyvbjerg
- You have accessBiological role of noise encoded in a genetic network motif
- From the Cover
Mark Kittisopikul and Gürol M. SüelSee companion article:
- Bacteria determine fate by playing dice with controlled odds- Jul 21, 2010
- You have accessCooperative formation of native-like tertiary contacts in the ensemble of unfolded states of a four-helix proteinSusanne W. Bruun, Vytautas Iešmantavičius, Jens Danielsson, and Flemming M. Poulsen
Cell Biology
- You have accessPhosphorylation stabilizes Nanog by promoting its interaction with Pin1Matteo Moretto-Zita, Hua Jin, Zhouxin Shen, Tongbiao Zhao, Steven P. Briggs, and Yang Xu
- You have accessALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLSShuo-Chien Ling, Claudio P. Albuquerque, Joo Seok Han, Clotilde Lagier-Tourenne, Seiya Tokunaga, Huilin Zhou, and Don W. Cleveland
- Open AccessRegulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions
- From the Cover
Nicolas Borghi, Molly Lowndes, Venkat Maruthamuthu, Margaret L. Gardel, and W. James NelsonPNAS July 27, 2010 107 (30) 13324-13329; first published June 21, 2010. https://doi.org/10.1073/pnas.1002662107See companion article:
- Dissecting cell adhesion cross-talk with micropatterns- Jul 16, 2010
- You have accessA non-ring-like form of the Dam1 complex modulates microtubule dynamics in fission yeastQi Gao, Thibault Courtheoux, Yannick Gachet, Sylvie Tournier, and Xiangwei He
- You have access3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells
- From the Cover
Richard L. Felts, Kedar Narayan, Jacob D. Estes, Dan Shi, Charles M. Trubey, Jing Fu, Lisa M. Hartnell, Gordon T. Ruthel, Douglas K. Schneider, Kunio Nagashima, Julian W. Bess Jr., Sina Bavari, Bradley C. Lowekamp, Donald Bliss, Jeffrey D. Lifson, and Sriram Subramaniam - You have accessMagnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular deliveryAnders Wittrup, Si-He Zhang, Katrin J. Svensson, Paulina Kucharzewska, Maria C. Johansson, Matthias Mörgelin, and Mattias Belting
- You have accessMetacaspase Yca1 is required for clearance of insoluble protein aggregatesRobin E. C. Lee, Steve Brunette, Lawrence G. Puente, and Lynn A. Megeney
Developmental Biology
- Open AccessAutomated vocal analysis of naturalistic recordings from children with autism, language delay, and typical developmentD. K. Oller, P. Niyogi, S. Gray, J. A. Richards, J. Gilkerson, D. Xu, U. Yapanel, and S. F. Warren
- You have accessGenome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testisMark W. Murphy, Aaron L. Sarver, Daren Rice, Katerina Hatzi, Kenny Ye, Ari Melnick, Leslie L. Heckert, David Zarkower, and Vivian J. Bardwell
- You have accessMaturation of the olfactory sensory neurons by Apaf-1/caspase-9–mediated caspase activityShizue Ohsawa, Shun Hamada, Keisuke Kuida, Hiroki Yoshida, Tatsushi Igaki, and Masayuki Miura
Environmental Sciences
- Open AccessControl of transpiration by radiationRoland Pieruschka, Gregor Huber, and Joseph A. Berry
Evolution
- You have accessOrigin of a function by tandem gene duplication limits the evolutionary capability of its sister copyMartin Hasselmann, Sarah Lechner, Christina Schulte, and Martin Beye
Genetics
- Open AccessPMS2 endonuclease activity has distinct biological functions and is essential for genome maintenanceJohanna M. M. van Oers, Sergio Roa, Uwe Werling, Yiyong Liu, Jochen Genschel, Harry Hou Jr., Rani S. Sellers, Paul Modrich, Matthew D. Scharff, and Winfried Edelmann
- Open AccessDNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instabilityFanny Lemée, Valérie Bergoglio, Anne Fernandez-Vidal, Alice Machado-Silva, Marie-Jeanne Pillaire, Anne Bieth, Catherine Gentil, Lee Baker, Anne-Laure Martin, Claire Leduc, Elena Lam, Eddy Magdeleine, Thomas Filleron, Naïma Oumouhou, Bernd Kaina, Mineaki Seki, Fanny Grimal, Magali Lacroix-Triki, Alastair Thompson, Henri Roché, Jean-Christophe Bourdon, Richard D. Wood, Jean-Sébastien Hoffmann, and Christophe Cazaux
- You have accessIncreased activity of Diaphanous homolog 3 (DIAPH3)/diaphanous causes hearing defects in humans with auditory neuropathy and in DrosophilaCynthia J. Schoen, Sarah B. Emery, Marc C. Thorne, Hima R. Ammana, Elżbieta Śliwerska, Jameson Arnett, Michael Hortsch, Frances Hannan, Margit Burmeister, and Marci M. Lesperance
Immunology
- You have accessProgrammed death-1 (PD-1)–deficient mice are extraordinarily sensitive to tuberculosisEszter Lázár-Molnár, Bing Chen, Kari A. Sweeney, Emilie J. Wang, Weijun Liu, Juan Lin, Steven A. Porcelli, Steven C. Almo, Stanley G. Nathenson, and William R. Jacobs Jr.
- You have accessA structural basis for antigen recognition by the T cell-like lymphocytes of sea lampreyLu Deng, C. Alejandro Velikovsky, Gang Xu, Lakshminarayan M. Iyer, Satoshi Tasumi, Melissa C. Kerzic, Martin F. Flajnik, L. Aravind, Zeev Pancer, and Roy A. Mariuzza
- You have accessEphB–ephrin-B2 interactions are required for thymus migration during organogenesisKatie E. Foster, Julie Gordon, Kim Cardenas, Henrique Veiga-Fernandes, Taija Makinen, Elena Grigorieva, David G. Wilkinson, C. Clare Blackburn, Ellen Richie, Nancy R. Manley, Ralf H. Adams, Dimitris Kioussis, and Mark C. Coles
Medical Sciences
- You have accessTopological optimization for designing patient-specific large craniofacial segmental bone replacementsAlok Sutradhar, Glaucio H. Paulino, Michael J. Miller, and Tam H. Nguyen
- You have accessMammalian life-span determinant p66shcA mediates obesity-induced insulin resistanceSofia Chiatamone Ranieri, Salvatore Fusco, Emiliano Panieri, Valentina Labate, Marina Mele, Valentina Tesori, Anna Maria Ferrara, Giuseppe Maulucci, Marco De Spirito, Giuseppe Ettore Martorana, Tommaso Galeotti, and Giovambattista Pani
- Open AccessReversal of hyperglycemia in diabetic mouse models using induced-pluripotent stem (iPS)-derived pancreatic β-like cellsZaida Alipio, Wenbin Liao, Elizabeth J. Roemer, Milton Waner, Louis M. Fink, David C. Ward, and Yupo Ma
- Open AccessArsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effectorJynho Kim, John J. Lee, James Kim, Dale Gardner, and Philip A. Beachy
- You have accessNotch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinomaPawel K. Mazur, Henrik Einwächter, Marcel Lee, Bence Sipos, Hassan Nakhai, Roland Rad, Ursula Zimber-Strobl, Lothar J. Strobl, Freddy Radtke, Günter Klöppel, Roland M. Schmid, and Jens T. Siveke
- You have accessE3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activationYi Yang, HanhChi Do, Xuejun Tian, Chaozheng Zhang, Xinyuan Liu, Laura A. Dada, Jacob I. Sznajder, and Jing Liu
- Open AccessMicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitroYun Fang, Congzhu Shi, Elisabetta Manduchi, Mete Civelek, and Peter F. Davies
Microbiology
- Open AccessEssential genes from Arctic bacteria used to construct stable, temperature-sensitive bacterial vaccinesBarry N. Duplantis, Milan Osusky, Crystal L. Schmerk, Darrell R. Ross, Catharine M. Bosio, and Francis E. NanoPNAS July 27, 2010 107 (30) 13456-13460; first published July 12, 2010. https://doi.org/10.1073/pnas.1004119107
- Open AccessMicrobisporicin gene cluster reveals unusual features of lantibiotic biosynthesis in actinomycetesLucy C. Foulston and Mervyn J. Bibb
- You have accessStructural organization of the functional domains of Clostridium difficile toxins A and BRory N. Pruitt, Melissa G. Chambers, Kenneth K.-S. Ng, Melanie D. Ohi, and D. Borden Lacy
- You have accessRole of a disintegrin and metalloprotease 10 in Staphylococcus aureus α-hemolysin–mediated cellular injuryGeorgia A. Wilke and Juliane Bubeck Wardenburg
- Open AccessA Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteriaSebastian Lücker, Michael Wagner, Frank Maixner, Eric Pelletier, Hanna Koch, Benoit Vacherie, Thomas Rattei, Jaap S. Sinninghe Damsté, Eva Spieck, Denis Le Paslier, and Holger Daims
Neuroscience
- You have accessCortical and subcortical interactions during action reprogramming and their related white matter pathwaysFranz-Xaver Neubert, Rogier B. Mars, Ethan R. Buch, Etienne Olivier, and Matthew F. S. Rushworth
- Open AccessNetwork architecture of the long-distance pathways in the macaque brainDharmendra S. Modha and Raghavendra Singh
- Open AccessAbsence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioningJones G. Parker, Larry S. Zweifel, Jeremy J. Clark, Scott B. Evans, Paul E. M. Phillips, and Richard D. Palmiter
- Open AccessSurprising gene expression patterns within and between PDF-containing circadian neurons in DrosophilaElzbieta Kula-Eversole, Emi Nagoshi, Yuhua Shang, Joseph Rodriguez, Ravi Allada, and Michael Rosbash
- Open AccessLearning-dependent plasticity with and without training in the human brainJiaxiang Zhang and Zoe Kourtzi
- You have accessA genetically modulated, intrinsic cingulate circuit supports human nicotine addictionL. Elliot Hong, Colin A. Hodgkinson, Yihong Yang, Hemalatha Sampath, Thomas J. Ross, Brittany Buchholz, Betty Jo Salmeron, Vibhuti Srivastava, Gunvant K. Thaker, David Goldman, and Elliot A. Stein
- Open AccessTGF-β2 alters the characteristics of the neuromuscular junction by regulating presynaptic quantal sizeSitt Wai Fong, Ian S. McLennan, Andrew McIntyre, Jayne Reid, Kathleen I. J. Shennan, and Guy S. Bewick
Pharmacology
- You have accessNicotinic pharmacophore: The pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH
- From the Cover
- Inaugural Article
Angela P. Blum, Henry A. Lester, and Dennis A. DoughertySee companion article:
- Defining the determinants of nicotine selectivity- Jul 19, 2010
- You have accessIdentification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligandsPhilippe de Medina, Michael R. Paillasse, Gregory Segala, Marc Poirot, and Sandrine Silvente-Poirot
Physiology
- You have accessTissue kallikrein permits early renal adaptation to potassium loadSoumaya El Moghrabi, Pascal Houillier, Nicolas Picard, Fabien Sohet, Bharath Wootla, May Bloch-Faure, Françoise Leviel, Lydie Cheval, Sebastian Frische, Pierre Meneton, Dominique Eladari, and Régine Chambrey
Plant Biology
- You have accessDivergent metabolome and proteome suggest functional independence of dual phloem transport systems in cucurbits
- From the Cover
Baichen Zhang, Vladimir Tolstikov, Colin Turnbull, Leslie M. Hicks, and Oliver FiehnSee companion article:
- The secret phloem of pumpkins- Jul 19, 2010
- You have accessCryptochrome 2 and phototropin 2 regulate resistance protein-mediated viral defense by negatively regulating an E3 ubiquitin ligaseRae-Dong Jeong, A. C. Chandra-Shekara, Subhankar Roy Barman, Duroy Navarre, Daniel F. Klessig, Aardra Kachroo, and Pradeep Kachroo
- You have accessA unique wheat disease resistance-like gene governs effector-triggered susceptibility to necrotrophic pathogensJustin D. Faris, Zengcui Zhang, Huangjun Lu, Shunwen Lu, Leela Reddy, Sylvie Cloutier, John P. Fellers, Steven W. Meinhardt, Jack B. Rasmussen, Steven S. Xu, Richard P. Oliver, Kristin J. Simons, and Timothy L. Friesen
Systems Biology
- Open AccessFourier analysis and systems identification of the p53 feedback loopNaama Geva-Zatorsky, Erez Dekel, Eric Batchelor, Galit Lahav, and Uri Alon
Commentaries
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