Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Coexpression of potato type I and II proteinase inhibitors gives cotton plants protection against insect damage in the field

    K. M. Dunse, J. A. Stevens, F. T. Lay, Y. M. Gaspar, R. L. Heath, and M. A. Anderson

    PNAS August 24, 2010 107 (34) 15011-15015; https://doi.org/10.1073/pnas.1009241107
  • Open Access

    Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor

    K. M. Dunse, Q. Kaas, R. F. Guarino, P. A. Barton, D. J. Craik, and M. A. Anderson

    PNAS August 24, 2010 107 (34) 15016-15021; https://doi.org/10.1073/pnas.1009327107

• Applied Biological Sciences

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    Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases

    Melanie Meyer, Martin Hrabé de Angelis, Wolfgang Wurst, and Ralf Kühn

    PNAS August 24, 2010 107 (34) 15022-15026; https://doi.org/10.1073/pnas.1009424107

• Biochemistry

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    Vitamin K epoxide reductase prefers ER membrane-anchored thioredoxin-like redox partners

    Sol Schulman, Belinda Wang, Weikai Li, and Tom A. Rapoport

    PNAS August 24, 2010 107 (34) 15027-15032; https://doi.org/10.1073/pnas.1009972107
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    Conformational dynamics of bacteriophage T7 DNA polymerase and its processivity factor, Escherichia coli thioredoxin

    Barak Akabayov, Sabine R. Akabayov, Seung-Joo Lee, Stanley Tabor, Arkadiusz W. Kulczyk, and Charles C. Richardson

    PNAS August 24, 2010 107 (34) 15033-15038; https://doi.org/10.1073/pnas.1010141107
  • Open Access

    Structural basis for high-affinity HER2 receptor binding by an engineered protein

    Charles Eigenbrot, Mark Ultsch, Anatoly Dubnovitsky, Lars Abrahmsén, and Torleif Härd

    PNAS August 24, 2010 107 (34) 15039-15044; https://doi.org/10.1073/pnas.1005025107
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    Structure and function of the polymerase core of TRAMP, a RNA surveillance complex

    Stephanie Hamill, Sandra L. Wolin, and Karin M. Reinisch

    PNAS August 24, 2010 107 (34) 15045-15050; https://doi.org/10.1073/pnas.1003505107
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    Dysregulation of the mevalonate pathway promotes transformation

    James W. Clendening, Aleks Pandyra, Paul C. Boutros, Samah El Ghamrasni, Fereshteh Khosravi, Grace A. Trentin, Anna Martirosyan, Anne Hakem, Razqallah Hakem, Igor Jurisica, and Linda Z. Penn

    PNAS August 24, 2010 107 (34) 15051-15056; https://doi.org/10.1073/pnas.0910258107
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    Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli

    Mikhail Bogdanov, Philip Heacock, Ziqiang Guan, and William Dowhan

    PNAS August 24, 2010 107 (34) 15057-15062; https://doi.org/10.1073/pnas.1006286107

• Biophysics and Computational Biology

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    Imaging in-plane and normal stresses near an interface crack using traction force microscopy

    Ye Xu, Wilfried C. Engl, Elizabeth R. Jerison, Kevin J. Wallenstein, Callen Hyland, Larry A. Wilen, and Eric R. Dufresne

    PNAS August 24, 2010 107 (34) 14964-14967; https://doi.org/10.1073/pnas.1005537107
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    Anisotropy of wave propagation in the heart can be modeled by a Riemannian electrophysiological metric

    Robert J. Young and Alexander V. Panfilov

    PNAS August 24, 2010 107 (34) 15063-15068; https://doi.org/10.1073/pnas.1008837107
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    Missense mutations in dystrophin that trigger muscular dystrophy decrease protein stability and lead to cross-β aggregates

    Surinder M. Singh, Narsimulu Kongari, Javier Cabello-Villegas, and Krishna M. G. Mallela

    PNAS August 24, 2010 107 (34) 15069-15074; https://doi.org/10.1073/pnas.1008818107
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    Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

    Rudresh Acharya, Vincenzo Carnevale, Giacomo Fiorin, Benjamin G. Levine, Alexei L. Polishchuk, Victoria Balannik, Ilan Samish, Robert A. Lamb, Lawrence H. Pinto, William F. DeGrado, and Michael L. Klein

    PNAS August 24, 2010 107 (34) 15075-15080; https://doi.org/10.1073/pnas.1007071107

• Cell Biology

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    Mechanisms of estrogen receptor antagonism toward p53 and its implications in breast cancer therapeutic response and stem cell regulation

    Santhi D. Konduri, Rajesh Medisetty, Wensheng Liu, Benny Abraham Kaipparettu, Pratima Srivastava, Hiltrud Brauch, Peter Fritz, Wendy M. Swetzig, Amanda E. Gardner, Sohaib A. Khan, and Gokul M. Das

    PNAS August 24, 2010 107 (34) 15081-15086; https://doi.org/10.1073/pnas.1009575107
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    Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen

    Xiaoyi V. Hu, Tânia M. A. Rodrigues, Haiyan Tao, Robert K. Baker, Loren Miraglia, Anthony P. Orth, Gary E. Lyons, Peter G. Schultz, and Xu Wu

    PNAS August 24, 2010 107 (34) 15087-15092; https://doi.org/10.1073/pnas.1009025107
  • Open Access

    Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization

    Supriya G. Prasanth, Zhen Shen, Kannanganattu V. Prasanth, and Bruce Stillman

    PNAS August 24, 2010 107 (34) 15093-15098; https://doi.org/10.1073/pnas.1009945107
  • Open Access

    Small-molecule inducers of insulin expression in pancreatic α-cells

    Dina Fomina-Yadlin, Stefan Kubicek, Deepika Walpita, Vlado Dančik, Jacob Hecksher-Sørensen, Joshua A. Bittker, Tanaz Sharifnia, Alykhan Shamji, Paul A. Clemons, Bridget K. Wagner, and Stuart L. Schreiber

    PNAS August 24, 2010 107 (34) 15099-15104; https://doi.org/10.1073/pnas.1010018107
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    T-cell receptor complex is essential for Fas signal transduction

    Askar M. Akimzhanov, Xinmin Wang, Jiaren Sun, and Darren Boehning

    PNAS August 24, 2010 107 (34) 15105-15110; https://doi.org/10.1073/pnas.1005419107
  • Open Access

    Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining

    J. C. Bruusgaard, I. B. Johansen, I. M. Egner, Z. A. Rana, and K. Gundersen

    PNAS August 24, 2010 107 (34) 15111-15116; https://doi.org/10.1073/pnas.0913935107
  • Open Access

    Clustering of dispersed ribosomal DNA and its role in gene regulation and chromosome-end associations in malaria parasites

    Liliana Mancio-Silva, Qingfeng Zhang, Christine Scheidig-Benatar, and Artur Scherf

    PNAS August 24, 2010 107 (34) 15117-15122; https://doi.org/10.1073/pnas.1001045107
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    Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H₂O₂ and superoxide dismutase activity

    Ana Mesquita, Martin Weinberger, Alexandra Silva, Belém Sampaio-Marques, Bruno Almeida, Cecília Leão, Vítor Costa, Fernando Rodrigues, William C. Burhans, and Paula Ludovico

    PNAS August 24, 2010 107 (34) 15123-15128; https://doi.org/10.1073/pnas.1004432107

• Ecology

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    Filtration of submicrometer particles by pelagic tunicates

    Kelly R. Sutherland, Laurence P. Madin, and Roman Stocker

    PNAS August 24, 2010 107 (34) 15129-15134; https://doi.org/10.1073/pnas.1003599107
  • Open Access

    Influence of climate on malaria transmission depends on daily temperature variation

    Krijn P. Paaijmans, Simon Blanford, Andrew S. Bell, Justine I. Blanford, Andrew F. Read, and Matthew B. Thomas

    PNAS August 24, 2010 107 (34) 15135-15139; https://doi.org/10.1073/pnas.1006422107

• Genetics

  • Open Access

    Oligogenic basis of isolated gonadotropin-releasing hormone deficiency

    Gerasimos P. Sykiotis, Lacey Plummer, Virginia A. Hughes, Margaret Au, Sadia Durrani, Sadhana Nayak-Young, Andrew A. Dwyer, Richard Quinton, Janet E. Hall, James F. Gusella, Stephanie B. Seminara, William F. Crowley Jr., and Nelly Pitteloud

    PNAS August 24, 2010 107 (34) 15140-15144; https://doi.org/10.1073/pnas.1009622107
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    PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice

    George Poulogiannis, Rebecca E. McIntyre, Maria Dimitriadi, John R. Apps, Catherine H. Wilson, Koichi Ichimura, Feijun Luo, Lewis C. Cantley, Andrew H. Wyllie, David J. Adams, and Mark J. Arends

    PNAS August 24, 2010 107 (34) 15145-15150; https://doi.org/10.1073/pnas.1009941107
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    Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Krüppel-like factor

    Miroslawa Siatecka, Kenneth E. Sahr, Sabra G. Andersen, Mihaly Mezei, James J. Bieker, and Luanne L. Peters

    PNAS August 24, 2010 107 (34) 15151-15156; https://doi.org/10.1073/pnas.1004996107
  • Open Access

    TCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions

    Michael P. Verzi, Pantelis Hatzis, Rita Sulahian, Juliet Philips, Jurian Schuijers, Hyunjin Shin, Ellen Freed, John P. Lynch, Duyen T. Dang, Myles Brown, Hans Clevers, X. Shirley Liu, and Ramesh A. Shivdasani

    PNAS August 24, 2010 107 (34) 15157-15162; https://doi.org/10.1073/pnas.1003822107
  • Open Access

    Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

    Jr-Shiuan Yang, Thomas Maurin, Nicolas Robine, Kasper D. Rasmussen, Kate L. Jeffrey, Rohit Chandwani, Eirini P. Papapetrou, Michel Sadelain, Dónal O'Carroll, and Eric C. Lai

    PNAS August 24, 2010 107 (34) 15163-15168; https://doi.org/10.1073/pnas.1006432107

• Immunology

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    Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitis

    Srimoyee Ghosh, Sergei B. Koralov, Irena Stevanovic, Mark S. Sundrud, Yoshiteru Sasaki, Klaus Rajewsky, Anjana Rao, and Martin R. Müller

    PNAS August 24, 2010 107 (34) 15169-15174; https://doi.org/10.1073/pnas.1009193107
  • Open Access

    AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIV_cpz

    Natasja G. de Groot, Corrine M. C. Heijmans, Yvonne M. Zoet, Arnoud H. de Ru, Frank A. Verreck, Peter A. van Veelen, Jan W. Drijfhout, Gaby G. M. Doxiadis, Edmond J. Remarque, Ilias I. N. Doxiadis, Jon J. van Rood, Frits Koning, and Ronald E. Bontrop

    PNAS August 24, 2010 107 (34) 15175-15180; https://doi.org/10.1073/pnas.1009136107
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    Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

    Taeil Kim, Shwetha Pazhoor, Musheng Bao, Zhiqiang Zhang, Shino Hanabuchi, Valeria Facchinetti, Laura Bover, Joel Plumas, Laurence Chaperot, Jun Qin, and Yong-Jun Liu

    PNAS August 24, 2010 107 (34) 15181-15186; https://doi.org/10.1073/pnas.1006539107
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    Fine analysis of spontaneous MAGE-C1/CT7–specific immunity in melanoma patients

    Natko Nuber, Alessandra Curioni-Fontecedro, Claudia Matter, Davide Soldini, Jean Marie Tiercy, Lotta von Boehmer, Holger Moch, Reinhard Dummer, Alexander Knuth, and Maries van den Broek

    PNAS August 24, 2010 107 (34) 15187-15192; https://doi.org/10.1073/pnas.1002155107
  • Open Access

    Defective feedback regulation of NF-κB underlies Sjögren’s syndrome in mice with mutated κB enhancers of the IκBα promoter

    Bailu Peng, Jianhua Ling, Andrew Joon Lee, Zilai Wang, Zhe Chang, Wei Jin, Ya'an Kang, Richard Zhang, David Shim, Huamin Wang, Jason B. Fleming, Hui Zheng, Shao-Cong Sun, and Paul J. Chiao

    PNAS August 24, 2010 107 (34) 15193-15198; https://doi.org/10.1073/pnas.1005533107

• Medical Sciences

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    Local prolactin is a target to prevent expansion of basal/stem cells in prostate tumors

    Vincent Rouet, Roman L. Bogorad, Christine Kayser, Karima Kessal, Catherine Genestie, Armelle Bardier, David R. Grattan, Bruce Kelder, John J. Kopchick, Paul A. Kelly, and Vincent Goffin

    PNAS August 24, 2010 107 (34) 15199-15204; https://doi.org/10.1073/pnas.0911651107
  • Open Access

    Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain

    Hao-Li Liu, Mu-Yi Hua, Hung-Wei Yang, Chiung-Yin Huang, Po-Chun Chu, Jia-Shin Wu, I-Chou Tseng, Jiun-Jie Wang, Tzu-Chen Yen, Pin-Yuan Chen, and Kuo-Chen Wei

    PNAS August 24, 2010 107 (34) 15205-15210; https://doi.org/10.1073/pnas.1003388107
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    Proangiogenic scaffolds as functional templates for cardiac tissue engineering

    Lauran R. Madden, Derek J. Mortisen, Eric M. Sussman, Sarah K. Dupras, James A. Fugate, Janet L. Cuy, Kip D. Hauch, Michael A. Laflamme, Charles E. Murry, and Buddy D. Ratner

    PNAS August 24, 2010 107 (34) 15211-15216; https://doi.org/10.1073/pnas.1006442107

• Microbiology

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    Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection

    Alexander Sheh, Chung Wei Lee, Kenichi Masumura, Barry H. Rickman, Takehiko Nohmi, Gerald N. Wogan, James G. Fox, and David B. Schauer

    PNAS August 24, 2010 107 (34) 15217-15222; https://doi.org/10.1073/pnas.1009017107
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    A small RNA promotes siderophore production through transcriptional and metabolic remodeling

    Hubert Salvail, Pascale Lanthier-Bourbonnais, Jason Michael Sobota, Mélissa Caza, Julie-Anna M. Benjamin, Martha Eugènia Sequeira Mendieta, François Lépine, Charles M. Dozois, James Imlay, and Eric Massé

    PNAS August 24, 2010 107 (34) 15223-15228; https://doi.org/10.1073/pnas.1007805107

• Neuroscience

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    Economic choices can be made using only stimulus values

    Klaus Wunderlich, Antonio Rangel, and John P. O'Doherty

    PNAS August 24, 2010 107 (34) 15005-15010; https://doi.org/10.1073/pnas.1002258107
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    GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models

    • From the Cover

    Xiaoying Lu, Edward Roberts, Fengcheng Xia, Manuel Sanchez-Alavez, Tianyu Liu, Roger Baldwin, Stephanie Wu, James Chang, Claude G. Wasterlain, and Tamas Bartfai

    PNAS August 24, 2010 107 (34) 15229-15234; https://doi.org/10.1073/pnas.1008986107

    See companion article:

    • Neuropeptide receptor positive allosteric modulation in epilepsy: Galanin modulation revealed

      - Aug 16, 2010
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    Hypothesis-driven structural connectivity analysis supports network over hierarchical model of brain architecture

    • From the Cover

    Richard H. Thompson and Larry W. Swanson

    PNAS August 24, 2010 107 (34) 15235-15239; https://doi.org/10.1073/pnas.1009112107
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    Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

    Qing-Jun Meng, Elizabeth S. Maywood, David A. Bechtold, Wei-Qun Lu, Jian Li, Julie E. Gibbs, Sandrine M. Dupré, Johanna E. Chesham, Francis Rajamohan, John Knafels, Blossom Sneed, Laura E. Zawadzke, Jeffrey F. Ohren, Kevin M. Walton, Travis T. Wager, Michael H. Hastings, and Andrew S. I. Loudon

    PNAS August 24, 2010 107 (34) 15240-15245; https://doi.org/10.1073/pnas.1005101107
  • Open Access

    Cortical depth-specific microvascular dilation underlies laminar differences in blood oxygenation level-dependent functional MRI signal

    Peifang Tian, Ivan C. Teng, Larry D. May, Ronald Kurz, Kun Lu, Miriam Scadeng, Elizabeth M. C. Hillman, Alex J. De Crespigny, Helen E. D’Arceuil, Joseph B. Mandeville, John J. A. Marota, Bruce R. Rosen, Thomas T. Liu, David A. Boas, Richard B. Buxton, Anders M. Dale, and Anna Devor

    PNAS August 24, 2010 107 (34) 15246-15251; https://doi.org/10.1073/pnas.1006735107
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    Specific involvement of postsynaptic GluN2B-containing NMDA receptors in the developmental elimination of corticospinal synapses

    Takae Ohno, Hitoshi Maeda, Naoyuki Murabe, Tsutomu Kamiyama, Noboru Yoshioka, Masayoshi Mishina, and Masaki Sakurai

    PNAS August 24, 2010 107 (34) 15252-15257; https://doi.org/10.1073/pnas.0906551107
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    Ectopic vesicular neurotransmitter release along sensory axons mediates neurovascular coupling via glial calcium signaling

    Anne Thyssen, Daniela Hirnet, Hartwig Wolburg, Günther Schmalzing, Joachim W. Deitmer, and Christian Lohr

    PNAS August 24, 2010 107 (34) 15258-15263; https://doi.org/10.1073/pnas.1003501107

• Physiology

  • Open Access

    Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain

    • From the Cover

    Catrin Swantje Müller, Alexander Haupt, Wolfgang Bildl, Jens Schindler, Hans-Günther Knaus, Marcel Meissner, Burkhard Rammner, Jörg Striessnig, Veit Flockerzi, Bernd Fakler, and Uwe Schulte

    PNAS August 24, 2010 107 (34) 14950-14957; https://doi.org/10.1073/pnas.1005940107

    See companion article:

    • Age of quantitative proteomics hits voltage-gated calcium channels

      - Aug 12, 2010
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    A mammalian neural tissue opsin (Opsin 5) is a deep brain photoreceptor in birds

    Yusuke Nakane, Keisuke Ikegami, Hiroko Ono, Naoyuki Yamamoto, Shosei Yoshida, Kanjun Hirunagi, Shizufumi Ebihara, Yoshihiro Kubo, and Takashi Yoshimura

    PNAS August 24, 2010 107 (34) 15264-15268; https://doi.org/10.1073/pnas.1006393107

    See companion article:

    • Shedding light on photoperiodism

      - Aug 27, 2010

• Plant Biology

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    22-nucleotide RNAs trigger secondary siRNA biogenesis in plants

    • From the Cover

    Ho-Ming Chen, Li-Teh Chen, Kanu Patel, Yi-Hang Li, David C. Baulcombe, and Shu-Hsing Wu

    PNAS August 24, 2010 107 (34) 15269-15274; https://doi.org/10.1073/pnas.1001738107

    See companion article:

    • RNA silencing amplification in plants: Size matters

      - Aug 13, 2010
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    CULLIN 4-RING FINGER-LIGASE plays a key role in the control of endoreplication cycles in Arabidopsis trichomes

    Farshad Roodbarkelari, Jonathan Bramsiepe, Christina Weinl, Sebastian Marquardt, Béla Novák, Marc J. Jakoby, Esther Lechner, Pascal Genschik, and Arp Schnittger

    PNAS August 24, 2010 107 (34) 15275-15280; https://doi.org/10.1073/pnas.1006941107
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    AtsPLA₂-α nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response

    Solène Froidure, Joanne Canonne, Xavier Daniel, Alain Jauneau, Christian Brière, Dominique Roby, and Susana Rivas

    PNAS August 24, 2010 107 (34) 15281-15286; https://doi.org/10.1073/pnas.1009056107
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    Vinca drug components accumulate exclusively in leaf exudates of Madagascar periwinkle

    • From the Cover

    Jonathan Roepke, Vonny Salim, Maggie Wu, Antje M. K. Thamm, Jun Murata, Kerstin Ploss, Wilhelm Boland, and Vincenzo De Luca

    PNAS August 24, 2010 107 (34) 15287-15292; https://doi.org/10.1073/pnas.0911451107
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    Carbohydrate-binding modules promote the enzymatic deconstruction of intact plant cell walls by targeting and proximity effects

    Cécile Hervé, Artur Rogowski, Anthony W. Blake, Susan E. Marcus, Harry J. Gilbert, and J. Paul Knox

    PNAS August 24, 2010 107 (34) 15293-15298; https://doi.org/10.1073/pnas.1005732107

• Systems Biology

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    Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)

    Kunhong Xiao, Jinpeng Sun, Jihee Kim, Sudarshan Rajagopal, Bo Zhai, Judit Villén, Wilhelm Haas, Jeffrey J. Kovacs, Arun K. Shukla, Makoto R. Hara, Marylens Hernandez, Alexander Lachmann, Shan Zhao, Yuan Lin, Yishan Cheng, Kensaku Mizuno, Avi Ma'ayan, Steven P. Gygi, and Robert J. Lefkowitz

    PNAS August 24, 2010 107 (34) 15299-15304; https://doi.org/10.1073/pnas.1008461107