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Prenatal undernutrition and cognitive function in late adulthood

Susanne R. de Rooij, Hans Wouters, Julie E. Yonker, Rebecca C. Painter, and Tessa J. Roseboom
PNAS September 28, 2010 107 (39) 16881-16886; https://doi.org/10.1073/pnas.1009459107
Susanne R. de Rooij
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Hans Wouters
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Julie E. Yonker
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Rebecca C. Painter
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Tessa J. Roseboom
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  1. Edited by R. Michael Roberts, University of Missouri-Columbia, Columbia, MO, and approved August 17, 2010 (received for review July 15, 2010)

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Abstract

At the end of World War II, a severe 5-mo famine struck the cities in the western part of The Netherlands. At its peak, the rations dropped to as low as 400 calories per day. In 1972, cognitive performance in 19-y-old male conscripts was reported not to have been affected by exposure to the famine before birth. In the present study, we show that cognitive function in later life does seem affected by prenatal undernutrition. We found that at age 56 to 59, men and women exposed to famine during the early stage of gestation performed worse on a selective attention task, a cognitive ability that usually declines with increasing age. We hypothesize that this decline may be an early manifestation of an accelerated cognitive aging process.

  • developmental origins
  • fetal
  • nutrition
  • cognition
  • aging

Footnotes

  • 1To whom correspondence should be addressed. E-mail: s.r.derooij{at}amc.uva.nl.
  • Author contributions: R.C.P. and T.J.R. designed research; S.R.d.R. and R.C.P. performed research; S.R.d.R., H.W., and J.E.Y. analyzed data; and S.R.d.R., H.W., J.E.Y., R.C.P., and T.J.R. wrote the paper.

  • The authors declare no conflict of interest.

  • See Commentary on page 16757.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1009459107/-/DCSupplemental.

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    Prenatal undernutrition and cognitive function in late adulthood
    Susanne R. de Rooij, Hans Wouters, Julie E. Yonker, Rebecca C. Painter, Tessa J. Roseboom
    Proceedings of the National Academy of Sciences Sep 2010, 107 (39) 16881-16886; DOI: 10.1073/pnas.1009459107

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    Prenatal undernutrition and cognitive function in late adulthood
    Susanne R. de Rooij, Hans Wouters, Julie E. Yonker, Rebecca C. Painter, Tessa J. Roseboom
    Proceedings of the National Academy of Sciences Sep 2010, 107 (39) 16881-16886; DOI: 10.1073/pnas.1009459107
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