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Research Article

Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development

Qin Yan, Lili Gong, Mi Deng, Lan Zhang, Shuming Sun, Jiao Liu, Haili Ma, Dan Yuan, Pei-Chao Chen, Xiaohui Hu, Jinping Liu, Jichao Qin, Ling Xiao, Xiao-Qin Huang, Jian Zhang, and David Wan-Cheng Li
PNAS December 7, 2010 107 (49) 21034-21039; https://doi.org/10.1073/pnas.1007866107
Qin Yan
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Lili Gong
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Mi Deng
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Lan Zhang
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Shuming Sun
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Dan Yuan
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  • For correspondence: dwli1688@hotmail.com
  1. Edited* by Michael Karin, University of California, San Diego School of Medicine, La Jolla, CA, and approved October 20, 2010 (received for review June 3, 2010)

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Article Information

vol. 107 no. 49 21034-21039
DOI: 
https://doi.org/10.1073/pnas.1007866107
PubMed: 
21084637

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue December 7, 2010.
  • Published first November 17, 2010.


Author Information

  1. Qin Yana,1,2,
  2. Lili Gonga,1,
  3. Mi Denga,1,
  4. Lan Zhangb,1,
  5. Shuming Suna,b,
  6. Jiao Liua,b,
  7. Haili Maa,
  8. Dan Yuana,
  9. Pei-Chao Chenb,
  10. Xiaohui Hub,
  11. Jinping Liua,
  12. Jichao Qina,3,
  13. Ling Xiaoa,b,
  14. Xiao-Qin Huangc,
  15. Jian Zhangb, and
  16. David Wan-Cheng Lia,b,d,4
  1. Departments of aBiochemistry and Molecular Biology and
  2. dOphthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, NE 68198;
  3. bKey Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of China, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; and
  4. cBiomedicine Engineering Center, Hunan University, Changsha, Hunan 410081, China
  1. Edited* by Michael Karin, University of California, San Diego School of Medicine, La Jolla, CA, and approved October 20, 2010 (received for review June 3, 2010)

  • ↵1Q.Y., L.G., M.D., and L.Z. contributed equally to this work.

  • ↵2Present Address: Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

  • ↵3Present address: Department of Surgery, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.

  • 4To whom correspondence should be addressed. E-mail: dwli1688{at}hotmail.com.

Footnotes

  • Author contributions: Q.Y., L.G., M.D., L.Z., and D.W.-C.L. designed research; Q.Y., L.G., M.D., L.Z., S.S., J.L., H.M., D.Y., P.-C.C., X.H., J.L., J.Q., L.X., and X.-Q.H. performed research; J.Z. contributed new reagents/analytic tools; Q.Y., L.G., M.D., L.Z., S.S., J.L., H.M., D.Y., P.-C.C., X.H., J.L., J.Q., L.X., X.-Q.H., J.Z., and D.W.-C.L. analyzed data; and D.W.-C.L. wrote the paper.

  • The authors declare no conflict of interest.

  • ↵*This Direct Submission article had a prearranged editor.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1007866107/-/DCSupplemental.

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Total 201817520671
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Mar 20191138
Apr 20194204
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Total 20193018591
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Apr 20201225
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Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development
Qin Yan, Lili Gong, Mi Deng, Lan Zhang, Shuming Sun, Jiao Liu, Haili Ma, Dan Yuan, Pei-Chao Chen, Xiaohui Hu, Jinping Liu, Jichao Qin, Ling Xiao, Xiao-Qin Huang, Jian Zhang, David Wan-Cheng Li
Proceedings of the National Academy of Sciences Dec 2010, 107 (49) 21034-21039; DOI: 10.1073/pnas.1007866107

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Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development
Qin Yan, Lili Gong, Mi Deng, Lan Zhang, Shuming Sun, Jiao Liu, Haili Ma, Dan Yuan, Pei-Chao Chen, Xiaohui Hu, Jinping Liu, Jichao Qin, Ling Xiao, Xiao-Qin Huang, Jian Zhang, David Wan-Cheng Li
Proceedings of the National Academy of Sciences Dec 2010, 107 (49) 21034-21039; DOI: 10.1073/pnas.1007866107
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Proceedings of the National Academy of Sciences: 107 (49)
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