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M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
Edited* by Robert J. Lefkowitz, Duke University Medical Center, The Howard Hughes Medical Institute, Durham, NC, and approved October 18, 2010 (received for review August 6, 2010)

Online Impact
Article Information
- Published in issue December 7, 2010.
- Published first November 15, 2010.
Author Information
- Kok Choi Konga,
- Adrian J. Butchera,
- Phillip McWilliamsa,
- David Jonesb,
- Jürgen Wessc,
- Fadi F. Hamdand,
- Tim Werrye,
- Elizabeth M. Rosethornef,
- Steven J. Charltonf,
- Sarah E. Munsong,
- Hannah A. Craggh,
- Alison D. Smarth, and
- Andrew B. Tobina,1
- aDepartment of Cell Physiology and Pharmacology,
- bBiomedical Joint Workshop,
- gGeneta Centre for Core Biotechnology Services, and
- hBiomedical Services Division, University of Leicester, Leicester LE1 9HN, United Kingdom;
- cMolecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
- dCenter of Excellence in Neuromics of University of Montreal, Sainte-Justine Hospital Research Center, Montreal, QC, Canada H3T 1C5;
- eNeurosciences Centre for Excellence in Drug Discovery, GlaxoSmithKline, Harlow CM19 5AW United Kingdom; and
- fNovartis Institutes for Biomedical Research, Horsham West, Sussex RH125AB United Kingdom
Edited* by Robert J. Lefkowitz, Duke University Medical Center, The Howard Hughes Medical Institute, Durham, NC, and approved October 18, 2010 (received for review August 6, 2010)
- 1To whom correspondence should be addressed. E-mail: tba{at}leicester.ac.uk.
Footnotes
Author contributions: A.B.T. designed research; K.C.K., A.J.B., P.M., E.M.R., H.A.C., and A.D.S. performed research; D.J., J.W., F.F.H., T.W., and S.E.M. contributed new reagents/analytic tools; K.C.K., A.J.B., E.M.R., S.J.C., and A.B.T. analyzed data; and A.B.T. wrote the paper.
The authors declare no conflict of interest.
↵*This Direct Submission article had a prearranged editor.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1011651107/-/DCSupplemental.
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