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Research Article

M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1

Kok Choi Kong, Adrian J. Butcher, Phillip McWilliams, David Jones, Jürgen Wess, Fadi F. Hamdan, Tim Werry, Elizabeth M. Rosethorne, Steven J. Charlton, Sarah E. Munson, Hannah A. Cragg, Alison D. Smart, and Andrew B. Tobin
PNAS December 7, 2010 107 (49) 21181-21186; https://doi.org/10.1073/pnas.1011651107
Kok Choi Kong
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Adrian J. Butcher
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Phillip McWilliams
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David Jones
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Jürgen Wess
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Fadi F. Hamdan
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Tim Werry
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Elizabeth M. Rosethorne
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Steven J. Charlton
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Sarah E. Munson
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Alison D. Smart
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Andrew B. Tobin
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  • For correspondence: tba@leicester.ac.uk
  1. Edited* by Robert J. Lefkowitz, Duke University Medical Center, The Howard Hughes Medical Institute, Durham, NC, and approved October 18, 2010 (received for review August 6, 2010)

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Article Information

vol. 107 no. 49 21181-21186
DOI: 
https://doi.org/10.1073/pnas.1011651107
PubMed: 
21078968

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue December 7, 2010.
  • Published first November 15, 2010.

Copyright & Usage: 
Freely available online through the PNAS open access option.

Author Information

  1. Kok Choi Konga,
  2. Adrian J. Butchera,
  3. Phillip McWilliamsa,
  4. David Jonesb,
  5. Jürgen Wessc,
  6. Fadi F. Hamdand,
  7. Tim Werrye,
  8. Elizabeth M. Rosethornef,
  9. Steven J. Charltonf,
  10. Sarah E. Munsong,
  11. Hannah A. Craggh,
  12. Alison D. Smarth, and
  13. Andrew B. Tobina,1
  1. aDepartment of Cell Physiology and Pharmacology,
  2. bBiomedical Joint Workshop,
  3. gGeneta Centre for Core Biotechnology Services, and
  4. hBiomedical Services Division, University of Leicester, Leicester LE1 9HN, United Kingdom;
  5. cMolecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;
  6. dCenter of Excellence in Neuromics of University of Montreal, Sainte-Justine Hospital Research Center, Montreal, QC, Canada H3T 1C5;
  7. eNeurosciences Centre for Excellence in Drug Discovery, GlaxoSmithKline, Harlow CM19 5AW United Kingdom; and
  8. fNovartis Institutes for Biomedical Research, Horsham West, Sussex RH125AB United Kingdom
  1. Edited* by Robert J. Lefkowitz, Duke University Medical Center, The Howard Hughes Medical Institute, Durham, NC, and approved October 18, 2010 (received for review August 6, 2010)

  • 1To whom correspondence should be addressed. E-mail: tba{at}leicester.ac.uk.

Footnotes

  • Author contributions: A.B.T. designed research; K.C.K., A.J.B., P.M., E.M.R., H.A.C., and A.D.S. performed research; D.J., J.W., F.F.H., T.W., and S.E.M. contributed new reagents/analytic tools; K.C.K., A.J.B., E.M.R., S.J.C., and A.B.T. analyzed data; and A.B.T. wrote the paper.

  • The authors declare no conflict of interest.

  • ↵*This Direct Submission article had a prearranged editor.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1011651107/-/DCSupplemental.

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Apr 201974210
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Total 201946334116
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M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
Kok Choi Kong, Adrian J. Butcher, Phillip McWilliams, David Jones, Jürgen Wess, Fadi F. Hamdan, Tim Werry, Elizabeth M. Rosethorne, Steven J. Charlton, Sarah E. Munson, Hannah A. Cragg, Alison D. Smart, Andrew B. Tobin
Proceedings of the National Academy of Sciences Dec 2010, 107 (49) 21181-21186; DOI: 10.1073/pnas.1011651107

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M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1
Kok Choi Kong, Adrian J. Butcher, Phillip McWilliams, David Jones, Jürgen Wess, Fadi F. Hamdan, Tim Werry, Elizabeth M. Rosethorne, Steven J. Charlton, Sarah E. Munson, Hannah A. Cragg, Alison D. Smart, Andrew B. Tobin
Proceedings of the National Academy of Sciences Dec 2010, 107 (49) 21181-21186; DOI: 10.1073/pnas.1011651107
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Proceedings of the National Academy of Sciences: 107 (49)
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