Proceedings of the National Academy of Sciences: 107 (50)

New Research In

December 14, 2010; vol. 107 no. 50

This Week in PNAS

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In This Issue
PNAS December 14, 2010 107 (50) 21231-21232; https://doi.org/10.1073/iti5010107

Letters (Online Only)

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Moral behavior is not what it seems
John Harris and Sarah Chan

PNAS December 14, 2010 107 (50) E183; https://doi.org/10.1073/pnas.1015001107
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Reply to Harris and Chan: Moral judgment is more than rational deliberation
Molly J. Crockett, Luke Clark, Marc D. Hauser, and Trevor W. Robbins

PNAS December 14, 2010 107 (50) E184; https://doi.org/10.1073/pnas.1015402107

Editorial

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Impacting our young
Eve Marder, Helmut Kettenmann, and Sten Grillner

PNAS December 14, 2010 107 (50) 21233; https://doi.org/10.1073/pnas.1016516107

Commentaries

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Paradise burnt: How colonizing humans transform landscapes with fire
David M. J. S. Bowman and Simon G. Haberle

PNAS December 14, 2010 107 (50) 21234-21235; https://doi.org/10.1073/pnas.1016393108
See companion article:
Rapid landscape transformation in South Island, New Zealand, following initial Polynesian settlement
- Dec 13, 2010
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And four equals one: Presenilin takes the γ-secretase role by itself
Christian B. Lessard, Steven L. Wagner, and Edward H. Koo

PNAS December 14, 2010 107 (50) 21236-21237; https://doi.org/10.1073/pnas.1016284108
See companion article:
Activation and intrinsic γ-secretase activity of presenilin 1
- Nov 29, 2010
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Tubulin acetyltransferase discovered: Ciliary role in the ancestral eukaryote expanded to neurons in metazoans
Michel R. Leroux

PNAS December 14, 2010 107 (50) 21238-21239; https://doi.org/10.1073/pnas.1016396108
See companion article:
The major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation
- Nov 10, 2010
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Unraveling the score of the enhancer symphony
Thomas P. Zwaka

PNAS December 14, 2010 107 (50) 21240-21241; https://doi.org/10.1073/pnas.1016297108
See companion article:
Histone H3K27ac separates active from poised enhancers and predicts developmental state
- Nov 24, 2010

Climate Change and Water in Southwestern North America Special Feature (free online)

Perspectives
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  Water, climate change, and sustainability in the southwest
  From the Cover
  
  Glen M. MacDonald
  
  PNAS December 14, 2010 107 (50) 21256-21262; https://doi.org/10.1073/pnas.0909651107
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  Reclaiming freshwater sustainability in the Cadillac Desert
  John L. Sabo, Tushar Sinha, Laura C. Bowling, Gerrit H. W. Schoups, Wesley W. Wallender, Michael E. Campana, Keith A. Cherkauer, Pam L. Fuller, William L. Graf, Jan W. Hopmans, John S. Kominoski, Carissa Taylor, Stanley W. Trimble, Robert H. Webb, and Ellen E. Wohl
  
  PNAS December 14, 2010 107 (50) 21263-21269; https://doi.org/10.1073/pnas.1009734108
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  Roadmap for sustainable water resources in southwestern North America
  Peter H. Gleick
  
  PNAS December 14, 2010 107 (50) 21300-21305; https://doi.org/10.1073/pnas.1005473107
Research Articles
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  Future dryness in the southwest US and the hydrology of the early 21st century drought
  Daniel R. Cayan, Tapash Das, David W. Pierce, Tim P. Barnett, Mary Tyree, and Alexander Gershunov
  
  PNAS December 14, 2010 107 (50) 21271-21276; https://doi.org/10.1073/pnas.0912391107
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  Greenhouse warming and the 21st century hydroclimate of southwestern North America
  Richard Seager and Gabriel A. Vecchi
  
  PNAS December 14, 2010 107 (50) 21277-21282; https://doi.org/10.1073/pnas.0910856107
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  A 1,200-year perspective of 21st century drought in southwestern North America
  Connie A. Woodhouse, David M. Meko, Glen M. MacDonald, Dave W. Stahle, and Edward R. Cook
  
  PNAS December 14, 2010 107 (50) 21283-21288; https://doi.org/10.1073/pnas.0911197107
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  Forest responses to increasing aridity and warmth in the southwestern United States
  A. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt
  
  PNAS December 14, 2010 107 (50) 21289-21294; https://doi.org/10.1073/pnas.0914211107
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  Vulnerability assessment of climate-induced water shortage in Phoenix
  Patricia Gober and Craig W. Kirkwood
  
  PNAS December 14, 2010 107 (50) 21295-21299; https://doi.org/10.1073/pnas.0911113107

Physical Sciences

Applied Physical Sciences
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  Luminescent nanocrystal stress gauge
  Charina L. Choi, Kristie J. Koski, Andrew C. K. Olson, and A. Paul Alivisatos
  
  PNAS December 14, 2010 107 (50) 21306-21310; https://doi.org/10.1073/pnas.1016022107
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  Organization of the polarization splay modulated smectic liquid crystal phase by topographic confinement
  Dong Ki Yoon, Rajdeep Deb, Dong Chen, Eva Körblova, Renfan Shao, Ken Ishikawa, Nandiraju V. S. Rao, David M. Walba, Ivan I. Smalyukh, and Noel A. Clark
  
  PNAS December 14, 2010 107 (50) 21311-21315; https://doi.org/10.1073/pnas.1014593107
Chemistry
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  In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
  Genevieve C. Van de Bittner, Elena A. Dubikovskaya, Carolyn R. Bertozzi, and Christopher J. Chang
  
  PNAS December 14, 2010 107 (50) 21316-21321; https://doi.org/10.1073/pnas.1012864107
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  Anabaena sensory rhodopsin is a light-driven unidirectional rotor
  Angela Strambi, Bo Durbeej, Nicolas Ferré, and Massimo Olivucci
  
  PNAS December 14, 2010 107 (50) 21322-21326; https://doi.org/10.1073/pnas.1015085107
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  Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase
  Samra Obeid, Anna Baccaro, Wolfram Welte, Kay Diederichs, and Andreas Marx
  
  PNAS December 14, 2010 107 (50) 21327-21331; https://doi.org/10.1073/pnas.1013804107
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  Rotational and constitutional dynamics of caged supramolecules
  Dirk Kühne, Florian Klappenberger, Wolfgang Krenner, Svetlana Klyatskaya, Mario Ruben, and Johannes V. Barth
  
  PNAS December 14, 2010 107 (50) 21332-21336; https://doi.org/10.1073/pnas.1008991107
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  Mechanism of action and inhibition of dehydrosqualene synthase
  Fu-Yang Lin, Chia-I Liu, Yi-Liang Liu, Yonghui Zhang, Ke Wang, Wen-Yih Jeng, Tzu-Ping Ko, Rong Cao, Andrew H.-J. Wang, and Eric Oldfield
  
  PNAS December 14, 2010 107 (50) 21337-21342; https://doi.org/10.1073/pnas.1010907107
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  Free energy profiles from single-molecule pulling experiments
  Gerhard Hummer and Attila Szabo
  
  PNAS December 14, 2010 107 (50) 21441-21446; https://doi.org/10.1073/pnas.1015661107
- You have access
  Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17
  Candace M. Pfefferkorn, Ryan P. McGlinchey, and Jennifer C. Lee
  
  PNAS December 14, 2010 107 (50) 21447-21452; https://doi.org/10.1073/pnas.1006424107
- You have access
  Relaxation mechanisms of UV-photoexcited DNA and RNA nucleobases
  Mario Barbatti, Adélia J. A. Aquino, Jaroslaw J. Szymczak, Dana Nachtigallová, Pavel Hobza, and Hans Lischka
  
  PNAS December 14, 2010 107 (50) 21453-21458; https://doi.org/10.1073/pnas.1014982107
- You have access
  Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires
  Govardhan Reddy, John E. Straub, and D. Thirumalai
  
  PNAS December 14, 2010 107 (50) 21459-21464; https://doi.org/10.1073/pnas.1008616107
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  Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly
  Olli Aitio, Maarit Hellman, Arunas Kazlauskas, Didier F. Vingadassalom, John M. Leong, Kalle Saksela, and Perttu Permi
  
  PNAS December 14, 2010 107 (50) 21743-21748; https://doi.org/10.1073/pnas.1010243107
Engineering
- Open Access
  Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells
  Yi Duan, Alan M. Weinstein, Sheldon Weinbaum, and Tong Wang
  
  PNAS December 14, 2010 107 (50) 21860-21865; https://doi.org/10.1073/pnas.1015751107
Environmental Sciences
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  Greenhouse warming and the 21st century hydroclimate of southwestern North America
  Richard Seager and Gabriel A. Vecchi
  
  PNAS December 14, 2010 107 (50) 21277-21282; https://doi.org/10.1073/pnas.0910856107
- You have access
  Rapid landscape transformation in South Island, New Zealand, following initial Polynesian settlement
  From the Cover
  
  David B. McWethy, Cathy Whitlock, Janet M. Wilmshurst, Matt S. McGlone, Mairie Fromont, Xun Li, Ann Dieffenbacher-Krall, William O. Hobbs, Sherilyn C. Fritz, and Edward R. Cook
  
  PNAS December 14, 2010 107 (50) 21343-21348; https://doi.org/10.1073/pnas.1011801107
  
  See companion article:
  Paradise burnt: How colonizing humans transform landscapes with fire
  - Dec 13, 2010
- Open Access
  Considerations for parameter optimization and sensitivity in climate models
  J. David Neelin, Annalisa Bracco, Hao Luo, James C. McWilliams, and Joyce E. Meyerson
  
  PNAS December 14, 2010 107 (50) 21349-21354; https://doi.org/10.1073/pnas.1015473107
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  Microbial excavation of solid carbonates powered by P-type ATPase-mediated transcellular Ca²⁺ transport
  Ferran Garcia-Pichel, Edgardo Ramírez-Reinat, and Qunjie Gao
  
  PNAS December 14, 2010 107 (50) 21749-21754; https://doi.org/10.1073/pnas.1011884108
Geology
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  Antarctic lakes suggest millennial reorganizations of Southern Hemisphere atmospheric and oceanic circulation
  Brenda L. Hall, George H. Denton, Andrew G. Fountain, Chris H. Hendy, and Gideon M. Henderson
  
  PNAS December 14, 2010 107 (50) 21355-21359; https://doi.org/10.1073/pnas.1007250107
Geophysics
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  Contribution of isoprene-derived organosulfates to free tropospheric aerosol mass
  K. D. Froyd, S. M. Murphy, D. M. Murphy, J. A. de Gouw, N. C. Eddingsaas, and P. O. Wennberg
  
  PNAS December 14, 2010 107 (50) 21360-21365; https://doi.org/10.1073/pnas.1012561107
Physics
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  Self-organization, condensation, and annihilation of topological vortices and antivortices in a multiferroic
  S. C. Chae, Y. Horibe, D. Y. Jeong, S. Rodan, N. Lee, and S.-W. Cheong
  
  PNAS December 14, 2010 107 (50) 21366-21370; https://doi.org/10.1073/pnas.1011380107
Sustainability Science
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  Future dryness in the southwest US and the hydrology of the early 21st century drought
  Daniel R. Cayan, Tapash Das, David W. Pierce, Tim P. Barnett, Mary Tyree, and Alexander Gershunov
  
  PNAS December 14, 2010 107 (50) 21271-21276; https://doi.org/10.1073/pnas.0912391107
- You have access
  A 1,200-year perspective of 21st century drought in southwestern North America
  Connie A. Woodhouse, David M. Meko, Glen M. MacDonald, Dave W. Stahle, and Edward R. Cook
  
  PNAS December 14, 2010 107 (50) 21283-21288; https://doi.org/10.1073/pnas.0911197107

Biological Sciences

Anthropology
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  Effects of Pleistocene glaciations and rivers on the population structure of Bornean orangutans (Pongo pygmaeus)
  Natasha Arora, Alexander Nater, Carel P. van Schaik, Erik P. Willems, Maria A. van Noordwijk, Benoit Goossens, Nadja Morf, Meredith Bastian, Cheryl Knott, Helen Morrogh-Bernard, Noko Kuze, Tomoko Kanamori, Joko Pamungkas, Dyah Perwitasari-Farajallah, Ernst Verschoor, Kristin Warren, and Michael Krützen
  
  PNAS December 14, 2010 107 (50) 21376-21381; https://doi.org/10.1073/pnas.1010169107
Biochemistry
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  In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
  Genevieve C. Van de Bittner, Elena A. Dubikovskaya, Carolyn R. Bertozzi, and Christopher J. Chang
  
  PNAS December 14, 2010 107 (50) 21316-21321; https://doi.org/10.1073/pnas.1012864107
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  UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region
  Hang Shi and Günter Blobel
  
  PNAS December 14, 2010 107 (50) 21382-21387; https://doi.org/10.1073/pnas.1013038107
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  Cation-π interaction regulates ligand-binding affinity and signaling of integrin α₄β₇
  YouDong Pan, Kun Zhang, JunPeng Qi, Jiao Yue, Timothy A. Springer, and JianFeng Chen
  
  PNAS December 14, 2010 107 (50) 21388-21393; https://doi.org/10.1073/pnas.1015487107
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  Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis
  Jared R. Auclair, Kristin J. Boggio, Gregory A. Petsko, Dagmar Ringe, and Jeffrey N. Agar
  
  PNAS December 14, 2010 107 (50) 21394-21399; https://doi.org/10.1073/pnas.1015463107
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  Structural identification of cation binding pockets in the plasma membrane proton pump
  Kira Ekberg, Bjørn P. Pedersen, Danny M. Sørensen, Ann K. Nielsen, Bjarke Veierskov, Poul Nissen, Michael G. Palmgren, and Morten J. Buch-Pedersen
  
  PNAS December 14, 2010 107 (50) 21400-21405; https://doi.org/10.1073/pnas.1010416107
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  Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes
  Andreja Vujičić-Žagar, Tjaard Pijning, Slavko Kralj, Cesar A. López, Wieger Eeuwema, Lubbert Dijkhuizen, and Bauke W. Dijkstra
  
  PNAS December 14, 2010 107 (50) 21406-21411; https://doi.org/10.1073/pnas.1007531107
- Open Access
  Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF
  Nicholas G. Housden, Justyna A. Wojdyla, Justyna Korczynska, Irina Grishkovskaya, Nadine Kirkpatrick, A. Marek Brzozowski, and Colin Kleanthous
  
  PNAS December 14, 2010 107 (50) 21412-21417; https://doi.org/10.1073/pnas.1010780107
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  Helicobacter pylori proinflammatory protein up-regulates NF-κB as a cell-translocating Ser/Thr kinase
  Do Jin Kim, Kang-Seo Park, Jung-Ho Kim, Sang-Hwa Yang, Ji Young Yoon, Byeong-Gu Han, Hyoun Sook Kim, Sang Jae Lee, Jun Young Jang, Kyoung Hoon Kim, Mi Jung Kim, Jin-Su Song, Hie-Joon Kim, Chung-Mo Park, Sang-Kyou Lee, Byung Il Lee, and Se Won Suh
  
  PNAS December 14, 2010 107 (50) 21418-21423; https://doi.org/10.1073/pnas.1010153107
- Open Access
  Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis
  Joon No Lee, Hyeonwoo Kim, Hongbing Yao, Yan Chen, Kayson Weng, and Jin Ye
  
  PNAS December 14, 2010 107 (50) 21424-21429; https://doi.org/10.1073/pnas.1011859107
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  Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery
  Xue-Ming Xu, Anton A. Turanov, Bradley A. Carlson, Min-Hyuk Yoo, Robert A. Everley, Renu Nandakumar, Irina Sorokina, Steven P. Gygi, Vadim N. Gladyshev, and Dolph L. Hatfield
  
  PNAS December 14, 2010 107 (50) 21430-21434; https://doi.org/10.1073/pnas.1009947107
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  Activation and intrinsic γ-secretase activity of presenilin 1
  From the Cover
  
  Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li
  
  PNAS December 14, 2010 107 (50) 21435-21440; https://doi.org/10.1073/pnas.1013246107
  
  See companion article:
  And four equals one: Presenilin takes the γ-secretase role by itself
  - Dec 06, 2010
Biophysics and Computational Biology
- You have access
  Anabaena sensory rhodopsin is a light-driven unidirectional rotor
  Angela Strambi, Bo Durbeej, Nicolas Ferré, and Massimo Olivucci
  
  PNAS December 14, 2010 107 (50) 21322-21326; https://doi.org/10.1073/pnas.1015085107
- You have access
  Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase
  Samra Obeid, Anna Baccaro, Wolfram Welte, Kay Diederichs, and Andreas Marx
  
  PNAS December 14, 2010 107 (50) 21327-21331; https://doi.org/10.1073/pnas.1013804107
- You have access
  Free energy profiles from single-molecule pulling experiments
  Gerhard Hummer and Attila Szabo
  
  PNAS December 14, 2010 107 (50) 21441-21446; https://doi.org/10.1073/pnas.1015661107
- You have access
  Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17
  Candace M. Pfefferkorn, Ryan P. McGlinchey, and Jennifer C. Lee
  
  PNAS December 14, 2010 107 (50) 21447-21452; https://doi.org/10.1073/pnas.1006424107
- You have access
  Relaxation mechanisms of UV-photoexcited DNA and RNA nucleobases
  Mario Barbatti, Adélia J. A. Aquino, Jaroslaw J. Szymczak, Dana Nachtigallová, Pavel Hobza, and Hans Lischka
  
  PNAS December 14, 2010 107 (50) 21453-21458; https://doi.org/10.1073/pnas.1014982107
- You have access
  Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires
  Govardhan Reddy, John E. Straub, and D. Thirumalai
  
  PNAS December 14, 2010 107 (50) 21459-21464; https://doi.org/10.1073/pnas.1008616107
- You have access
  Relationship between Ca²⁺-affinity and shielding of bulk water in the Ca²⁺-pump from molecular dynamics simulations
  Yuji Sugita, Mitsunori Ikeguchi, and Chikashi Toyoshima
  
  PNAS December 14, 2010 107 (50) 21465-21469; https://doi.org/10.1073/pnas.1015819107
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  Interheme electron tunneling in cytochrome c oxidase
  Ville R. I. Kaila, Mikael P. Johansson, Dage Sundholm, and Mårten Wikström
  
  PNAS December 14, 2010 107 (50) 21470-21475; https://doi.org/10.1073/pnas.1005889107
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  Protein structure determination by exhaustive search of Protein Data Bank derived databases
  Ian Stokes-Rees and Piotr Sliz
  
  PNAS December 14, 2010 107 (50) 21476-21481; https://doi.org/10.1073/pnas.1012095107
- Open Access
  Divalent counterion-induced condensation of triple-strand DNA
  Xiangyun Qiu, V. Adrian Parsegian, and Donald C. Rau
  
  PNAS December 14, 2010 107 (50) 21482-21486; https://doi.org/10.1073/pnas.1003374107
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  Identification of differential translation in genome wide studies
  Ola Larsson, Nahum Sonenberg, and Robert Nadon
  
  PNAS December 14, 2010 107 (50) 21487-21492; https://doi.org/10.1073/pnas.1006821107
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  Deconvolution of dynamic mechanical networks
  Michael Hinczewski, Yann von Hansen, and Roland R. Netz
  
  PNAS December 14, 2010 107 (50) 21493-21498; https://doi.org/10.1073/pnas.1010476107
Cell Biology
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  Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes
  Jinbo Yang, Jing Huang, Maupali Dasgupta, Nathan Sears, Masaru Miyagi, Benlian Wang, Mark R. Chance, Xing Chen, Yuping Du, Yuxin Wang, Lizhe An, Qin Wang, Tao Lu, Xiaodong Zhang, Zhenghe Wang, and George R. Stark
  
  PNAS December 14, 2010 107 (50) 21499-21504; https://doi.org/10.1073/pnas.1016147107
- You have access
  MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets
  A. G. Lisa Ooi, Debashis Sahoo, Maddalena Adorno, Yulei Wang, Irving L. Weissman, and Christopher Y. Park
  
  PNAS December 14, 2010 107 (50) 21505-21510; https://doi.org/10.1073/pnas.1016218107
- Open Access
  Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi
  Genevieve Ko, Summer Paradise, Hong Chen, Morven Graham, Manuela Vecchi, Fabrizio Bianchi, Ottavio Cremona, Pier Paolo Di Fiore, and Pietro De Camilli
  
  PNAS December 14, 2010 107 (50) 21511-21516; https://doi.org/10.1073/pnas.1016390107
- You have access
  The major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation
  Toshinobu Shida, Juan G. Cueva, Zhenjie Xu, Miriam B. Goodman, and Maxence V. Nachury
  
  PNAS December 14, 2010 107 (50) 21517-21522; https://doi.org/10.1073/pnas.1013728107
  
  See companion article:
  Tubulin acetyltransferase discovered: Ciliary role in the ancestral eukaryote expanded to neurons in metazoans
  - Dec 06, 2010
- You have access
  A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
  Sheung Kwan Lam, Naofumi Yoda, and Randy Schekman
  
  PNAS December 14, 2010 107 (50) 21523-21528; https://doi.org/10.1073/pnas.1013397107
  
  See companion article:
  A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
  - Apr 05, 2011
  
  A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
  - Apr 05, 2011
- You have access
  Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential
  Yoshinori Ohno, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Sayaka Mori, Miyuki Tsumura, Satoshi Okada, Tomohiko Ohta, Kiyoshi Ohtani, Masao Kobayashi, and Yoshihiro Takihara
  
  PNAS December 14, 2010 107 (50) 21529-21534; https://doi.org/10.1073/pnas.1011054107
- Open Access
  Pathology tissue–chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples
  Mirco Fanelli, Stefano Amatori, Iros Barozzi, Matias Soncini, Roberto Dal Zuffo, Gabriele Bucci, Maria Capra, Micaela Quarto, Gaetano Ivan Dellino, Ciro Mercurio, Myriam Alcalay, Giuseppe Viale, Pier Giuseppe Pelicci, and Saverio Minucci
  
  PNAS December 14, 2010 107 (50) 21535-21540; https://doi.org/10.1073/pnas.1007647107
- You have access
  Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1
  Melanie Stumpf, Xiaojing Yue, Sandra Schmitz, Hervé Luche, Janardan K. Reddy, and Tilman Borggrefe
  
  PNAS December 14, 2010 107 (50) 21541-21546; https://doi.org/10.1073/pnas.1005794107
- You have access
  Profilin1 regulates PI(3,4)P₂ and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells
  Yong Ho Bae, Zhijie Ding, Tuhin Das, Alan Wells, Frank Gertler, and Partha Roy
  
  PNAS December 14, 2010 107 (50) 21547-21552; https://doi.org/10.1073/pnas.1002309107
- Open Access
  KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents
  Kazunori Yoshikiyo, Katja Kratz, Kouji Hirota, Kana Nishihara, Minoru Takata, Hitoshi Kurumizaka, Satoshi Horimoto, Shunichi Takeda, and Josef Jiricny
  
  PNAS December 14, 2010 107 (50) 21553-21557; https://doi.org/10.1073/pnas.1011081107
Developmental Biology
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  MicroRNA miR-125b causes leukemia
  Marina Bousquet, Marian H. Harris, Beiyan Zhou, and Harvey F. Lodish
  
  PNAS December 14, 2010 107 (50) 21558-21563; https://doi.org/10.1073/pnas.1016611107
- You have access
  β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching
  David Enshell-Seijffers, Catherine Lindon, Eleanor Wu, Makoto M. Taketo, and Bruce A. Morgan
  
  PNAS December 14, 2010 107 (50) 21564-21569; https://doi.org/10.1073/pnas.1007326107
Ecology
- You have access
  Forest responses to increasing aridity and warmth in the southwestern United States
  A. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt
  
  PNAS December 14, 2010 107 (50) 21289-21294; https://doi.org/10.1073/pnas.0914211107
Environmental Sciences
- You have access
  Rapid landscape transformation in South Island, New Zealand, following initial Polynesian settlement
  From the Cover
  
  David B. McWethy, Cathy Whitlock, Janet M. Wilmshurst, Matt S. McGlone, Mairie Fromont, Xun Li, Ann Dieffenbacher-Krall, William O. Hobbs, Sherilyn C. Fritz, and Edward R. Cook
  
  PNAS December 14, 2010 107 (50) 21343-21348; https://doi.org/10.1073/pnas.1011801107
  
  See companion article:
  Paradise burnt: How colonizing humans transform landscapes with fire
  - Dec 13, 2010
Evolution
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  Source identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences
  Inaugural Article
  
  Diane I. Scaduto, Jeremy M. Brown, Wade C. Haaland, Derrick J. Zwickl, David M. Hillis, and Michael L. Metzker
  
  PNAS December 14, 2010 107 (50) 21242-21247; https://doi.org/10.1073/pnas.1015673107
  
  See companion article:
  Profile of David M. Hillis
  - Jun 13, 2011
- You have access
  Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax
  Aaron Avivi, Frank Gerlach, Alma Joel, Stefan Reuss, Thorsten Burmester, Eviatar Nevo, and Thomas Hankeln
  
  PNAS December 14, 2010 107 (50) 21570-21575; https://doi.org/10.1073/pnas.1015379107
- You have access
  Gorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversion
  Weilong Hao, Aaron O. Richardson, Yihong Zheng, and Jeffrey D. Palmer
  
  PNAS December 14, 2010 107 (50) 21576-21581; https://doi.org/10.1073/pnas.1016295107
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  Encephalization is not a universal macroevolutionary phenomenon in mammals but is associated with sociality
  Susanne Shultz and Robin Dunbar
  
  PNAS December 14, 2010 107 (50) 21582-21586; https://doi.org/10.1073/pnas.1005246107
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  Heritable victimization and the benefits of agonistic relationships
  Amanda J. Lea, Daniel T. Blumstein, Tina W. Wey, and Julien G. A. Martin
  
  PNAS December 14, 2010 107 (50) 21587-21592; https://doi.org/10.1073/pnas.1009882107
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  Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict
  Cheng Deng, C.-H. Christina Cheng, Hua Ye, Ximiao He, and Liangbiao Chen
  
  PNAS December 14, 2010 107 (50) 21593-21598; https://doi.org/10.1073/pnas.1007883107
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  Transspecies dimorphic allelic lineages of the proteasome subunit β-type 8 gene (PSMB8) in the teleost genus Oryzias
  Fumi Miura, Kentaro Tsukamoto, Ratnesh Bhai Mehta, Kiyoshi Naruse, Wichian Magtoon, and Masaru Nonaka
  
  PNAS December 14, 2010 107 (50) 21599-21604; https://doi.org/10.1073/pnas.1012881107
Genetics
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  Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae
  Salma Kaochar, Lisa Shanks, and Ted Weinert
  
  PNAS December 14, 2010 107 (50) 21605-21610; https://doi.org/10.1073/pnas.1001938107
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  Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome
  James Cockram, Jon White, Diana L. Zuluaga, David Smith, Jordi Comadran, Malcolm Macaulay, Zewei Luo, Mike J. Kearsey, Peter Werner, David Harrap, Chris Tapsell, Hui Liu, Peter E. Hedley, Nils Stein, Daniela Schulte, Burkhard Steuernagel, David F. Marshall, William T. B. Thomas, Luke Ramsay, Ian Mackay, David J. Balding, The AGOUEB Consortium, Robbie Waugh, and Donal M. O'Sullivan
  
  PNAS December 14, 2010 107 (50) 21611-21616; https://doi.org/10.1073/pnas.1010179107
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  Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors
  Robert Morbitzer, Patrick Römer, Jens Boch, and Thomas Lahaye
  
  PNAS December 14, 2010 107 (50) 21617-21622; https://doi.org/10.1073/pnas.1013133107
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  Jumonji domain protein JMJD5 functions in both the plant and human circadian systems
  Matthew A. Jones, Michael F. Covington, Luciano DiTacchio, Christopher Vollmers, Satchidananda Panda, and Stacey L. Harmer
  
  PNAS December 14, 2010 107 (50) 21623-21628; https://doi.org/10.1073/pnas.1014204108
Immunology
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  Dicer controls CD8⁺ T-cell activation, migration, and survival
  Nu Zhang and Michael J. Bevan
  
  PNAS December 14, 2010 107 (50) 21629-21634; https://doi.org/10.1073/pnas.1016299107
- You have access
  Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
  Bo Hu, Eran Elinav, Samuel Huber, Carmen J. Booth, Till Strowig, Chengcheng Jin, Stephanie C. Eisenbarth, and Richard A. Flavell
  
  PNAS December 14, 2010 107 (50) 21635-21640; https://doi.org/10.1073/pnas.1016814108
- You have access
  Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression
  Andreas Bergthaler, Lukas Flatz, Ahmed N. Hegazy, Susan Johnson, Edit Horvath, Max Löhning, and Daniel D. Pinschewer
  
  PNAS December 14, 2010 107 (50) 21641-21646; https://doi.org/10.1073/pnas.1011998107
- You have access
  Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Rα complexes
  Kutlu G. Elpek, Mark P. Rubinstein, Angelique Bellemare-Pelletier, Ananda W. Goldrath, and Shannon J. Turley
  
  PNAS December 14, 2010 107 (50) 21647-21652; https://doi.org/10.1073/pnas.1012128107
- You have access
  Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells
  Shilpa Raghuvanshi, Pawan Sharma, Sarman Singh, Luc Van Kaer, and Gobardhan Das
  
  PNAS December 14, 2010 107 (50) 21653-21658; https://doi.org/10.1073/pnas.1007967107
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  The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes
  Francesca Bellora, Roberta Castriconi, Alessandra Dondero, Giorgio Reggiardo, Lorenzo Moretta, Alberto Mantovani, Alessandro Moretta, and Cristina Bottino
  
  PNAS December 14, 2010 107 (50) 21659-21664; https://doi.org/10.1073/pnas.1007654108
Medical Sciences
- Open Access
  Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
  Inaugural Article
  
  Marcin Kowanetz, Xiumin Wu, John Lee, Martha Tan, Thijs Hagenbeek, Xueping Qu, Lanlan Yu, Jed Ross, Nina Korsisaari, Tim Cao, Hani Bou-Reslan, Dara Kallop, Robby Weimer, Mary J. C. Ludlam, Joshua S. Kaminker, Zora Modrusan, Nicholas van Bruggen, Franklin V. Peale, Richard Carano, Y. Gloria Meng, and Napoleone Ferrara
  
  PNAS December 14, 2010 107 (50) 21248-21255; https://doi.org/10.1073/pnas.1015855107
- You have access
  Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl
  Jie Lu, Jeffrey Chiang, Rajiv R. Iyer, Eli Thompson, Christine R. Kaneski, David S. Xu, Chunzhang Yang, Masako Chen, Richard J. Hodes, Russell R. Lonser, Roscoe O. Brady, and Zhengping Zhuang
  
  PNAS December 14, 2010 107 (50) 21665-21670; https://doi.org/10.1073/pnas.1014376107
- You have access
  Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice
  Tero A. H. Järvinen and Erkki Ruoslahti
  
  PNAS December 14, 2010 107 (50) 21671-21676; https://doi.org/10.1073/pnas.1016233107
- Open Access
  Malignant cells facilitate lung metastasis by bringing their own soil
  Dan G. Duda, Annique M. M. J. Duyverman, Mitsutomo Kohno, Matija Snuderl, Ernst J. A. Steller, Dai Fukumura, and Rakesh K. Jain
  
  PNAS December 14, 2010 107 (50) 21677-21682; https://doi.org/10.1073/pnas.1016234107
- You have access
  As₄S₄ targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia
  Jian-Hua Mao, Xiao-Yan Sun, Jian-Xiang Liu, Qun-Ye Zhang, Ping Liu, Qiu-Hua Huang, Keqin Kathy Li, Quan Chen, Zhu Chen, and Sai-Juan Chen
  
  PNAS December 14, 2010 107 (50) 21683-21688; https://doi.org/10.1073/pnas.1016311108
- You have access
  Regulation of hematopoietic stem cells by their mature progeny
  Carolyn A. de Graaf, Maria Kauppi, Tracey Baldwin, Craig D. Hyland, Donald Metcalf, Tracy A. Willson, Marina R. Carpinelli, Gordon K. Smyth, Warren S. Alexander, and Douglas J. Hilton
  
  PNAS December 14, 2010 107 (50) 21689-21694; https://doi.org/10.1073/pnas.1016166108
- You have access
  Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis
  George Trichonas, Yusuke Murakami, Aristomenis Thanos, Yuki Morizane, Maki Kayama, Christine M. Debouck, Toshio Hisatomi, Joan W. Miller, and Demetrios G. Vavvas
  
  PNAS December 14, 2010 107 (50) 21695-21700; https://doi.org/10.1073/pnas.1009179107
- Open Access
  Global capacity for emerging infectious disease detection
  Emily H. Chan, Timothy F. Brewer, Lawrence C. Madoff, Marjorie P. Pollack, Amy L. Sonricker, Mikaela Keller, Clark C. Freifeld, Michael Blench, Abla Mawudeku, and John S. Brownstein
  
  PNAS December 14, 2010 107 (50) 21701-21706; https://doi.org/10.1073/pnas.1006219107
- Open Access
  Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129
  John P. Mugler III, Talissa A. Altes, Iulian C. Ruset, Isabel M. Dregely, Jaime F. Mata, G. Wilson Miller, Stephen Ketel, Jeffrey Ketel, F. William Hersman, and Kai Ruppert
  
  PNAS December 14, 2010 107 (50) 21707-21712; https://doi.org/10.1073/pnas.1011912107
- You have access
  Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis
  Curtis J. Henry, Andriy Marusyk, Vadym Zaberezhnyy, Biniam Adane, and James DeGregori
  
  PNAS December 14, 2010 107 (50) 21713-21718; https://doi.org/10.1073/pnas.1005486107
- You have access
  Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia
  Kajsa Paulsson, Erik Forestier, Henrik Lilljebjörn, Jesper Heldrup, Mikael Behrendtz, Bryan D. Young, and Bertil Johansson
  
  PNAS December 14, 2010 107 (50) 21719-21724; https://doi.org/10.1073/pnas.1006981107
- You have access
  Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer
  Jean J. Latimer, Jennifer M. Johnson, Crystal M. Kelly, Tiffany D. Miles, Kelly A. Beaudry-Rodgers, Nancy A. Lalanne, Victor G. Vogel, Amal Kanbour-Shakir, Joseph L. Kelley, Ronald R. Johnson, and Stephen G. Grant
  
  PNAS December 14, 2010 107 (50) 21725-21730; https://doi.org/10.1073/pnas.0914772107
- Open Access
  Tailor-made RNAi knockdown against triplet repeat disease-causing alleles
  Masaki Takahashi, Shoko Watanabe, Miho Murata, Hirokazu Furuya, Ichiro Kanazawa, Keiji Wada, and Hirohiko Hohjoh
  
  PNAS December 14, 2010 107 (50) 21731-21736; https://doi.org/10.1073/pnas.1012153107
- You have access
  Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling
  Christine M. Fillmore, Piyush B. Gupta, Jenny A. Rudnick, Silvia Caballero, Patricia J. Keller, Eric S. Lander, and Charlotte Kuperwasser
  
  PNAS December 14, 2010 107 (50) 21737-21742; https://doi.org/10.1073/pnas.1007863107
Microbiology
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  Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly
  Olli Aitio, Maarit Hellman, Arunas Kazlauskas, Didier F. Vingadassalom, John M. Leong, Kalle Saksela, and Perttu Permi
  
  PNAS December 14, 2010 107 (50) 21743-21748; https://doi.org/10.1073/pnas.1010243107
- You have access
  Microbial excavation of solid carbonates powered by P-type ATPase-mediated transcellular Ca²⁺ transport
  Ferran Garcia-Pichel, Edgardo Ramírez-Reinat, and Qunjie Gao
  
  PNAS December 14, 2010 107 (50) 21749-21754; https://doi.org/10.1073/pnas.1011884108
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  Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii
  Chen Chen, Simran Banga, Katja Mertens, Mary M. Weber, Ivana Gorbaslieva, Yunhao Tan, Zhao-Qing Luo, and James E. Samuel
  
  PNAS December 14, 2010 107 (50) 21755-21760; https://doi.org/10.1073/pnas.1010485107
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  Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis
  Rainer Kalscheuer, Brian Weinrick, Usha Veeraraghavan, Gurdyal S. Besra, and William R. Jacobs Jr.
  
  PNAS December 14, 2010 107 (50) 21761-21766; https://doi.org/10.1073/pnas.1014642108
Neuroscience
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  How the brain integrates costs and benefits during decision making
  Ulrike Basten, Guido Biele, Hauke R. Heekeren, and Christian J. Fiebach
  
  PNAS December 14, 2010 107 (50) 21767-21772; https://doi.org/10.1073/pnas.0908104107
- Open Access
  Amygdala regulates risk of predation in rats foraging in a dynamic fear environment
  June-Seek Choi and Jeansok J. Kim
  
  PNAS December 14, 2010 107 (50) 21773-21777; https://doi.org/10.1073/pnas.1010079108
- You have access
  Caveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapses
  Yukihiro Takayasu, Koichi Takeuchi, Ranju Kumari, Michael V. L. Bennett, R. Suzanne Zukin, and Anna Francesconi
  
  PNAS December 14, 2010 107 (50) 21778-21783; https://doi.org/10.1073/pnas.1015553107
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  Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning
  Lenora Volk, Chong-Hyun Kim, Kogo Takamiya, Yilin Yu, and Richard L. Huganir
  
  PNAS December 14, 2010 107 (50) 21784-21789; https://doi.org/10.1073/pnas.1016103107
- Open Access
  Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
  Bjoern Schwer, Bjoern Schumacher, David B. Lombard, Cuiying Xiao, Martin V. Kurtev, Jun Gao, Jennifer I. Schneider, Hua Chai, Roderick T. Bronson, Li-Huei Tsai, Chu-Xia Deng, and Frederick W. Alt
  
  PNAS December 14, 2010 107 (50) 21790-21794; https://doi.org/10.1073/pnas.1016306107
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  Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression
  Christine D. Pozniak, Abraham J. Langseth, Gerrit J. P. Dijkgraaf, Youngshik Choe, Zena Werb, and Samuel J. Pleasure
  
  PNAS December 14, 2010 107 (50) 21795-21800; https://doi.org/10.1073/pnas.1016485107
- You have access
  Retrieval induces reconsolidation of fear extinction memory
  Janine I. Rossato, Lia R. Bevilaqua, Iván Izquierdo, Jorge H. Medina, and Martín Cammarota
  
  PNAS December 14, 2010 107 (50) 21801-21805; https://doi.org/10.1073/pnas.1016254107
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  Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity
  Maria Lindskog, Li Li, Rachel D. Groth, Damon Poburko, Tara C. Thiagarajan, Xue Han, and Richard W. Tsien
  
  PNAS December 14, 2010 107 (50) 21806-21811; https://doi.org/10.1073/pnas.1016399107
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  Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization
  Hyung Jin Ahn, Daria Zamolodchikov, Marta Cortes-Canteli, Erin H. Norris, J. Fraser Glickman, and Sidney Strickland
  
  PNAS December 14, 2010 107 (50) 21812-21817; https://doi.org/10.1073/pnas.1010373107
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  ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation
  Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Mei, and Tian-Ming Gao
  
  PNAS December 14, 2010 107 (50) 21818-21823; https://doi.org/10.1073/pnas.1010669107
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  Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with l-dopa–induced dyskinesia
  Stefania Fasano, Erwan Bezard, Angela D'Antoni, Veronica Francardo, Marzia Indrigo, Li Qin, Sandra Doveró, Milica Cerovic, M. Angela Cenci, and Riccardo Brambilla
  
  PNAS December 14, 2010 107 (50) 21824-21829; https://doi.org/10.1073/pnas.1012071107
- Open Access
  Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
  Eva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann, Rainer Schneider, Calum Sutherland, and Susann Schweiger
  
  PNAS December 14, 2010 107 (50) 21830-21835; https://doi.org/10.1073/pnas.0912793107
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  Nicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus
  Jufang Chang, Bin Zhang, Helen Heath, Niels Galjart, Xinyu Wang, and Jeffrey Milbrandt
  
  PNAS December 14, 2010 107 (50) 21836-21841; https://doi.org/10.1073/pnas.1002130107
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  Trial-to-trial variability of the prefrontal neurons reveals the nature of their engagement in a motion discrimination task
  Cory Hussar and Tatiana Pasternak
  
  PNAS December 14, 2010 107 (50) 21842-21847; https://doi.org/10.1073/pnas.1009956107
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  Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus
  Nicholas R. Wall, Ian R. Wickersham, Ali Cetin, Mauricio De La Parra, and Edward M. Callaway
  
  PNAS December 14, 2010 107 (50) 21848-21853; https://doi.org/10.1073/pnas.1011756107
Pharmacology
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  α-Dystrobrevin-1 recruits α-catulin to the α_1D-adrenergic receptor/dystrophin-associated protein complex signalosome
  John S. Lyssand, Jennifer L. Whiting, Kyung-Soon Lee, Ryan Kastl, Jennifer L. Wacker, Michael R. Bruchas, Mayumi Miyatake, Lorene K. Langeberg, Charles Chavkin, John D. Scott, Richard G. Gardner, Marvin E. Adams, and Chris Hague
  
  PNAS December 14, 2010 107 (50) 21854-21859; https://doi.org/10.1073/pnas.1010819107
Physiology
- Open Access
  Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells
  Yi Duan, Alan M. Weinstein, Sheldon Weinbaum, and Tong Wang
  
  PNAS December 14, 2010 107 (50) 21860-21865; https://doi.org/10.1073/pnas.1015751107
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  PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types
  Kyle A. Rasbach, Rana K. Gupta, Jorge L. Ruas, Jun Wu, Elnaz Naseri, Jennifer L. Estall, and Bruce M. Spiegelman
  
  PNAS December 14, 2010 107 (50) 21866-21871; https://doi.org/10.1073/pnas.1016089107
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  Deletion of hensin/DMBT1 blocks conversion of β- to α-intercalated cells and induces distal renal tubular acidosis
  XiaoBo Gao, Dominique Eladari, Francoise Leviel, Ben Yi Tew, Cristina Miró-Julià, Faisal H. Cheema, Lance Miller, Raoul Nelson, Teodor G. Păunescu, Mary McKee, Dennis Brown, and Qais Al-Awqati
  
  PNAS December 14, 2010 107 (50) 21872-21877; https://doi.org/10.1073/pnas.1010364107
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  Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood
  Claudia Sanchez-Cardenas, Pierre Fontanaud, Zhenhe He, Chrystel Lafont, Anne-Cécile Meunier, Marie Schaeffer, Danielle Carmignac, François Molino, Nathalie Coutry, Xavier Bonnefont, Laurie-Anne Gouty-Colomer, Elodie Gavois, David J. Hodson, Paul Le Tissier, Iain C. A. F. Robinson, and Patrice Mollard
  
  PNAS December 14, 2010 107 (50) 21878-21883; https://doi.org/10.1073/pnas.1010849107
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  Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion
  Maureen A. Kane, Alexandra E. Folias, Attilio Pingitore, Mariarita Perri, Kristin M. Obrochta, Charles R. Krois, Erika Cione, Joo Yeon Ryu, and Joseph L. Napoli
  
  PNAS December 14, 2010 107 (50) 21884-21889; https://doi.org/10.1073/pnas.1008859107
Plant Biology
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  ADP-ribosylation factor machinery mediates endocytosis in plant cells
  Satoshi Naramoto, Jürgen Kleine-Vehn, Stéphanie Robert, Masaru Fujimoto, Tomoko Dainobu, Tomasz Paciorek, Takashi Ueda, Akihiko Nakano, Marc C. E. Van Montagu, Hiroo Fukuda, and Jiří Friml
  
  PNAS December 14, 2010 107 (50) 21890-21895; https://doi.org/10.1073/pnas.1016260107
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  A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity
  Matt Humphry, Paweł Bednarek, Birgit Kemmerling, Serry Koh, Mónica Stein, Ulrike Göbel, Kurt Stüber, Mariola Piślewska-Bednarek, Ann Loraine, Paul Schulze-Lefert, Shauna Somerville, and Ralph Panstruga
  
  PNAS December 14, 2010 107 (50) 21896-21901; https://doi.org/10.1073/pnas.1003619107
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  An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus
  Richard A. Wilson, Robert P. Gibson, Cristian F. Quispe, Jennifer A. Littlechild, and Nicholas J. Talbot
  
  PNAS December 14, 2010 107 (50) 21902-21907; https://doi.org/10.1073/pnas.1006839107
- Open Access
  Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity
  Raúl Carranco, José Manuel Espinosa, Pilar Prieto-Dapena, Concepción Almoguera, and Juan Jordano
  
  PNAS December 14, 2010 107 (50) 21908-21913; https://doi.org/10.1073/pnas.1014856107
Psychological and Cognitive Sciences
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  Effects of oxytocin on recollections of maternal care and closeness
  Jennifer A. Bartz, Jamil Zaki, Kevin N. Ochsner, Niall Bolger, Alexander Kolevzon, Natasha Ludwig, and John E. Lydon
  
  PNAS December 14, 2010 107 (50) 21371-21375; https://doi.org/10.1073/pnas.1012669107
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  Rapid efficient coding of correlated complex acoustic properties
  Christian E. Stilp, Timothy T. Rogers, and Keith R. Kluender
  
  PNAS December 14, 2010 107 (50) 21914-21919; https://doi.org/10.1073/pnas.1009020107
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  Topological change disturbs object continuity in attentive tracking
  Ke Zhou, Huan Luo, Tiangang Zhou, Yan Zhuo, and Lin Chen
  
  PNAS December 14, 2010 107 (50) 21920-21924; https://doi.org/10.1073/pnas.1010919108
Sustainability Science
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  Forest responses to increasing aridity and warmth in the southwestern United States
  A. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt
  
  PNAS December 14, 2010 107 (50) 21289-21294; https://doi.org/10.1073/pnas.0914211107
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  Cost-effectiveness of dryland forest restoration evaluated by spatial analysis of ecosystem services
  Jennifer C. Birch, Adrian C. Newton, Claudia Alvarez Aquino, Elena Cantarello, Cristian Echeverría, Thomas Kitzberger, Ignacio Schiappacasse, and Natalia Tejedor Garavito
  
  PNAS December 14, 2010 107 (50) 21925-21930; https://doi.org/10.1073/pnas.1003369107
Systems Biology
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  Histone H3K27ac separates active from poised enhancers and predicts developmental state
  From the Cover
  
  Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead, Tristan Kooistra, Bryce W. Carey, Eveline J. Steine, Jacob Hanna, Michael A. Lodato, Garrett M. Frampton, Phillip A. Sharp, Laurie A. Boyer, Richard A. Young, and Rudolf Jaenisch
  
  PNAS December 14, 2010 107 (50) 21931-21936; https://doi.org/10.1073/pnas.1016071107
  
  See companion article:
  Unraveling the score of the enhancer symphony
  - Dec 06, 2010
- Open Access
  DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells
  Anand D. Jeyasekharan, Nabieh Ayoub, Robert Mahen, Jonas Ries, Alessandro Esposito, Eeson Rajendra, Hiroyoshi Hattori, Rajan P. Kulkarni, and Ashok R. Venkitaraman
  
  PNAS December 14, 2010 107 (50) 21937-21942; https://doi.org/10.1073/pnas.1009577107

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Correction for Choi et al., Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation
PNAS December 14, 2010 107 (50) 21943; https://doi.org/10.1073/pnas.1016618107
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Correction for Veiga et al., Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes
PNAS December 14, 2010 107 (50) 21943; https://doi.org/10.1073/pnas.1017174108

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