Table of Contents

Biological Sciences

• Anthropology

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    Effects of Pleistocene glaciations and rivers on the population structure of Bornean orangutans (Pongo pygmaeus)

    Natasha Arora, Alexander Nater, Carel P. van Schaik, Erik P. Willems, Maria A. van Noordwijk, Benoit Goossens, Nadja Morf, Meredith Bastian, Cheryl Knott, Helen Morrogh-Bernard, Noko Kuze, Tomoko Kanamori, Joko Pamungkas, Dyah Perwitasari-Farajallah, Ernst Verschoor, Kristin Warren, and Michael Krützen

    PNAS December 14, 2010 107 (50) 21376-21381; https://doi.org/10.1073/pnas.1010169107

• Biochemistry

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    In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

    Genevieve C. Van de Bittner, Elena A. Dubikovskaya, Carolyn R. Bertozzi, and Christopher J. Chang

    PNAS December 14, 2010 107 (50) 21316-21321; https://doi.org/10.1073/pnas.1012864107
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    UNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding region

    Hang Shi and Günter Blobel

    PNAS December 14, 2010 107 (50) 21382-21387; https://doi.org/10.1073/pnas.1013038107
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    Cation-π interaction regulates ligand-binding affinity and signaling of integrin α₄β₇

    YouDong Pan, Kun Zhang, JunPeng Qi, Jiao Yue, Timothy A. Springer, and JianFeng Chen

    PNAS December 14, 2010 107 (50) 21388-21393; https://doi.org/10.1073/pnas.1015487107
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    Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis

    Jared R. Auclair, Kristin J. Boggio, Gregory A. Petsko, Dagmar Ringe, and Jeffrey N. Agar

    PNAS December 14, 2010 107 (50) 21394-21399; https://doi.org/10.1073/pnas.1015463107
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    Structural identification of cation binding pockets in the plasma membrane proton pump

    Kira Ekberg, Bjørn P. Pedersen, Danny M. Sørensen, Ann K. Nielsen, Bjarke Veierskov, Poul Nissen, Michael G. Palmgren, and Morten J. Buch-Pedersen

    PNAS December 14, 2010 107 (50) 21400-21405; https://doi.org/10.1073/pnas.1010416107
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    Crystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymes

    Andreja Vujičić-Žagar, Tjaard Pijning, Slavko Kralj, Cesar A. López, Wieger Eeuwema, Lubbert Dijkhuizen, and Bauke W. Dijkstra

    PNAS December 14, 2010 107 (50) 21406-21411; https://doi.org/10.1073/pnas.1007531107
  • Open Access

    Directed epitope delivery across the Escherichia coli outer membrane through the porin OmpF

    Nicholas G. Housden, Justyna A. Wojdyla, Justyna Korczynska, Irina Grishkovskaya, Nadine Kirkpatrick, A. Marek Brzozowski, and Colin Kleanthous

    PNAS December 14, 2010 107 (50) 21412-21417; https://doi.org/10.1073/pnas.1010780107
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    Helicobacter pylori proinflammatory protein up-regulates NF-κB as a cell-translocating Ser/Thr kinase

    Do Jin Kim, Kang-Seo Park, Jung-Ho Kim, Sang-Hwa Yang, Ji Young Yoon, Byeong-Gu Han, Hyoun Sook Kim, Sang Jae Lee, Jun Young Jang, Kyoung Hoon Kim, Mi Jung Kim, Jin-Su Song, Hie-Joon Kim, Chung-Mo Park, Sang-Kyou Lee, Byung Il Lee, and Se Won Suh

    PNAS December 14, 2010 107 (50) 21418-21423; https://doi.org/10.1073/pnas.1010153107
  • Open Access

    Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

    Joon No Lee, Hyeonwoo Kim, Hongbing Yao, Yan Chen, Kayson Weng, and Jin Ye

    PNAS December 14, 2010 107 (50) 21424-21429; https://doi.org/10.1073/pnas.1011859107
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    Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery

    Xue-Ming Xu, Anton A. Turanov, Bradley A. Carlson, Min-Hyuk Yoo, Robert A. Everley, Renu Nandakumar, Irina Sorokina, Steven P. Gygi, Vadim N. Gladyshev, and Dolph L. Hatfield

    PNAS December 14, 2010 107 (50) 21430-21434; https://doi.org/10.1073/pnas.1009947107
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    Activation and intrinsic γ-secretase activity of presenilin 1

    • From the Cover

    Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming Li

    PNAS December 14, 2010 107 (50) 21435-21440; https://doi.org/10.1073/pnas.1013246107

    See companion article:

    • And four equals one: Presenilin takes the γ-secretase role by itself

      - Dec 06, 2010

• Biophysics and Computational Biology

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    Anabaena sensory rhodopsin is a light-driven unidirectional rotor

    Angela Strambi, Bo Durbeej, Nicolas Ferré, and Massimo Olivucci

    PNAS December 14, 2010 107 (50) 21322-21326; https://doi.org/10.1073/pnas.1015085107
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    Structural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymerase

    Samra Obeid, Anna Baccaro, Wolfram Welte, Kay Diederichs, and Andreas Marx

    PNAS December 14, 2010 107 (50) 21327-21331; https://doi.org/10.1073/pnas.1013804107
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    Free energy profiles from single-molecule pulling experiments

    Gerhard Hummer and Attila Szabo

    PNAS December 14, 2010 107 (50) 21441-21446; https://doi.org/10.1073/pnas.1015661107
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    Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17

    Candace M. Pfefferkorn, Ryan P. McGlinchey, and Jennifer C. Lee

    PNAS December 14, 2010 107 (50) 21447-21452; https://doi.org/10.1073/pnas.1006424107
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    Relaxation mechanisms of UV-photoexcited DNA and RNA nucleobases

    Mario Barbatti, Adélia J. A. Aquino, Jaroslaw J. Szymczak, Dana Nachtigallová, Pavel Hobza, and Hans Lischka

    PNAS December 14, 2010 107 (50) 21453-21458; https://doi.org/10.1073/pnas.1014982107
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    Dry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wires

    Govardhan Reddy, John E. Straub, and D. Thirumalai

    PNAS December 14, 2010 107 (50) 21459-21464; https://doi.org/10.1073/pnas.1008616107
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    Relationship between Ca²⁺-affinity and shielding of bulk water in the Ca²⁺-pump from molecular dynamics simulations

    Yuji Sugita, Mitsunori Ikeguchi, and Chikashi Toyoshima

    PNAS December 14, 2010 107 (50) 21465-21469; https://doi.org/10.1073/pnas.1015819107
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    Interheme electron tunneling in cytochrome c oxidase

    Ville R. I. Kaila, Mikael P. Johansson, Dage Sundholm, and Mårten Wikström

    PNAS December 14, 2010 107 (50) 21470-21475; https://doi.org/10.1073/pnas.1005889107
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    Protein structure determination by exhaustive search of Protein Data Bank derived databases

    Ian Stokes-Rees and Piotr Sliz

    PNAS December 14, 2010 107 (50) 21476-21481; https://doi.org/10.1073/pnas.1012095107
  • Open Access

    Divalent counterion-induced condensation of triple-strand DNA

    Xiangyun Qiu, V. Adrian Parsegian, and Donald C. Rau

    PNAS December 14, 2010 107 (50) 21482-21486; https://doi.org/10.1073/pnas.1003374107
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    Identification of differential translation in genome wide studies

    Ola Larsson, Nahum Sonenberg, and Robert Nadon

    PNAS December 14, 2010 107 (50) 21487-21492; https://doi.org/10.1073/pnas.1006821107
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    Deconvolution of dynamic mechanical networks

    Michael Hinczewski, Yann von Hansen, and Roland R. Netz

    PNAS December 14, 2010 107 (50) 21493-21498; https://doi.org/10.1073/pnas.1010476107

• Cell Biology

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    Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

    Jinbo Yang, Jing Huang, Maupali Dasgupta, Nathan Sears, Masaru Miyagi, Benlian Wang, Mark R. Chance, Xing Chen, Yuping Du, Yuxin Wang, Lizhe An, Qin Wang, Tao Lu, Xiaodong Zhang, Zhenghe Wang, and George R. Stark

    PNAS December 14, 2010 107 (50) 21499-21504; https://doi.org/10.1073/pnas.1016147107
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    MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets

    A. G. Lisa Ooi, Debashis Sahoo, Maddalena Adorno, Yulei Wang, Irving L. Weissman, and Christopher Y. Park

    PNAS December 14, 2010 107 (50) 21505-21510; https://doi.org/10.1073/pnas.1016218107
  • Open Access

    Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi

    Genevieve Ko, Summer Paradise, Hong Chen, Morven Graham, Manuela Vecchi, Fabrizio Bianchi, Ottavio Cremona, Pier Paolo Di Fiore, and Pietro De Camilli

    PNAS December 14, 2010 107 (50) 21511-21516; https://doi.org/10.1073/pnas.1016390107
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    The major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensation

    Toshinobu Shida, Juan G. Cueva, Zhenjie Xu, Miriam B. Goodman, and Maxence V. Nachury

    PNAS December 14, 2010 107 (50) 21517-21522; https://doi.org/10.1073/pnas.1013728107

    See companion article:

    • Tubulin acetyltransferase discovered: Ciliary role in the ancestral eukaryote expanded to neurons in metazoans

      - Dec 06, 2010
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    A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum

    Sheung Kwan Lam, Naofumi Yoda, and Randy Schekman

    PNAS December 14, 2010 107 (50) 21523-21528; https://doi.org/10.1073/pnas.1013397107

    See companion article:

    • A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum

      - Apr 05, 2011
    • A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum

      - Apr 05, 2011
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    Hoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potential

    Yoshinori Ohno, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Sayaka Mori, Miyuki Tsumura, Satoshi Okada, Tomohiko Ohta, Kiyoshi Ohtani, Masao Kobayashi, and Yoshihiro Takihara

    PNAS December 14, 2010 107 (50) 21529-21534; https://doi.org/10.1073/pnas.1011054107
  • Open Access

    Pathology tissue–chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples

    Mirco Fanelli, Stefano Amatori, Iros Barozzi, Matias Soncini, Roberto Dal Zuffo, Gabriele Bucci, Maria Capra, Micaela Quarto, Gaetano Ivan Dellino, Ciro Mercurio, Myriam Alcalay, Giuseppe Viale, Pier Giuseppe Pelicci, and Saverio Minucci

    PNAS December 14, 2010 107 (50) 21535-21540; https://doi.org/10.1073/pnas.1007647107
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    Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

    Melanie Stumpf, Xiaojing Yue, Sandra Schmitz, Hervé Luche, Janardan K. Reddy, and Tilman Borggrefe

    PNAS December 14, 2010 107 (50) 21541-21546; https://doi.org/10.1073/pnas.1005794107
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    Profilin1 regulates PI(3,4)P₂ and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

    Yong Ho Bae, Zhijie Ding, Tuhin Das, Alan Wells, Frank Gertler, and Partha Roy

    PNAS December 14, 2010 107 (50) 21547-21552; https://doi.org/10.1073/pnas.1002309107
  • Open Access

    KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

    Kazunori Yoshikiyo, Katja Kratz, Kouji Hirota, Kana Nishihara, Minoru Takata, Hitoshi Kurumizaka, Satoshi Horimoto, Shunichi Takeda, and Josef Jiricny

    PNAS December 14, 2010 107 (50) 21553-21557; https://doi.org/10.1073/pnas.1011081107

• Developmental Biology

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    MicroRNA miR-125b causes leukemia

    Marina Bousquet, Marian H. Harris, Beiyan Zhou, and Harvey F. Lodish

    PNAS December 14, 2010 107 (50) 21558-21563; https://doi.org/10.1073/pnas.1016611107
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    β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching

    David Enshell-Seijffers, Catherine Lindon, Eleanor Wu, Makoto M. Taketo, and Bruce A. Morgan

    PNAS December 14, 2010 107 (50) 21564-21569; https://doi.org/10.1073/pnas.1007326107

• Ecology

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    Forest responses to increasing aridity and warmth in the southwestern United States

    A. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt

    PNAS December 14, 2010 107 (50) 21289-21294; https://doi.org/10.1073/pnas.0914211107

• Environmental Sciences

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    Rapid landscape transformation in South Island, New Zealand, following initial Polynesian settlement

    • From the Cover

    David B. McWethy, Cathy Whitlock, Janet M. Wilmshurst, Matt S. McGlone, Mairie Fromont, Xun Li, Ann Dieffenbacher-Krall, William O. Hobbs, Sherilyn C. Fritz, and Edward R. Cook

    PNAS December 14, 2010 107 (50) 21343-21348; https://doi.org/10.1073/pnas.1011801107

    See companion article:

    • Paradise burnt: How colonizing humans transform landscapes with fire

      - Dec 13, 2010

• Evolution

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    Source identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences

    • Inaugural Article

    Diane I. Scaduto, Jeremy M. Brown, Wade C. Haaland, Derrick J. Zwickl, David M. Hillis, and Michael L. Metzker

    PNAS December 14, 2010 107 (50) 21242-21247; https://doi.org/10.1073/pnas.1015673107

    See companion article:

    • Profile of David M. Hillis

      - Jun 13, 2011
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    Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax

    Aaron Avivi, Frank Gerlach, Alma Joel, Stefan Reuss, Thorsten Burmester, Eviatar Nevo, and Thomas Hankeln

    PNAS December 14, 2010 107 (50) 21570-21575; https://doi.org/10.1073/pnas.1015379107
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    Gorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversion

    Weilong Hao, Aaron O. Richardson, Yihong Zheng, and Jeffrey D. Palmer

    PNAS December 14, 2010 107 (50) 21576-21581; https://doi.org/10.1073/pnas.1016295107
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    Encephalization is not a universal macroevolutionary phenomenon in mammals but is associated with sociality

    Susanne Shultz and Robin Dunbar

    PNAS December 14, 2010 107 (50) 21582-21586; https://doi.org/10.1073/pnas.1005246107
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    Heritable victimization and the benefits of agonistic relationships

    Amanda J. Lea, Daniel T. Blumstein, Tina W. Wey, and Julien G. A. Martin

    PNAS December 14, 2010 107 (50) 21587-21592; https://doi.org/10.1073/pnas.1009882107
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    Evolution of an antifreeze protein by neofunctionalization under escape from adaptive conflict

    Cheng Deng, C.-H. Christina Cheng, Hua Ye, Ximiao He, and Liangbiao Chen

    PNAS December 14, 2010 107 (50) 21593-21598; https://doi.org/10.1073/pnas.1007883107
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    Transspecies dimorphic allelic lineages of the proteasome subunit β-type 8 gene (PSMB8) in the teleost genus Oryzias

    Fumi Miura, Kentaro Tsukamoto, Ratnesh Bhai Mehta, Kiyoshi Naruse, Wichian Magtoon, and Masaru Nonaka

    PNAS December 14, 2010 107 (50) 21599-21604; https://doi.org/10.1073/pnas.1012881107

• Genetics

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    Checkpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiae

    Salma Kaochar, Lisa Shanks, and Ted Weinert

    PNAS December 14, 2010 107 (50) 21605-21610; https://doi.org/10.1073/pnas.1001938107
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    Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome

    James Cockram, Jon White, Diana L. Zuluaga, David Smith, Jordi Comadran, Malcolm Macaulay, Zewei Luo, Mike J. Kearsey, Peter Werner, David Harrap, Chris Tapsell, Hui Liu, Peter E. Hedley, Nils Stein, Daniela Schulte, Burkhard Steuernagel, David F. Marshall, William T. B. Thomas, Luke Ramsay, Ian Mackay, David J. Balding, The AGOUEB Consortium, Robbie Waugh, and Donal M. O'Sullivan

    PNAS December 14, 2010 107 (50) 21611-21616; https://doi.org/10.1073/pnas.1010179107
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    Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

    Robert Morbitzer, Patrick Römer, Jens Boch, and Thomas Lahaye

    PNAS December 14, 2010 107 (50) 21617-21622; https://doi.org/10.1073/pnas.1013133107
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    Jumonji domain protein JMJD5 functions in both the plant and human circadian systems

    Matthew A. Jones, Michael F. Covington, Luciano DiTacchio, Christopher Vollmers, Satchidananda Panda, and Stacey L. Harmer

    PNAS December 14, 2010 107 (50) 21623-21628; https://doi.org/10.1073/pnas.1014204108

• Immunology

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    Dicer controls CD8⁺ T-cell activation, migration, and survival

    Nu Zhang and Michael J. Bevan

    PNAS December 14, 2010 107 (50) 21629-21634; https://doi.org/10.1073/pnas.1016299107
  • You have access

    Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4

    Bo Hu, Eran Elinav, Samuel Huber, Carmen J. Booth, Till Strowig, Chengcheng Jin, Stephanie C. Eisenbarth, and Richard A. Flavell

    PNAS December 14, 2010 107 (50) 21635-21640; https://doi.org/10.1073/pnas.1016814108
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    Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression

    Andreas Bergthaler, Lukas Flatz, Ahmed N. Hegazy, Susan Johnson, Edit Horvath, Max Löhning, and Daniel D. Pinschewer

    PNAS December 14, 2010 107 (50) 21641-21646; https://doi.org/10.1073/pnas.1011998107
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    Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Rα complexes

    Kutlu G. Elpek, Mark P. Rubinstein, Angelique Bellemare-Pelletier, Ananda W. Goldrath, and Shannon J. Turley

    PNAS December 14, 2010 107 (50) 21647-21652; https://doi.org/10.1073/pnas.1012128107
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    Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells

    Shilpa Raghuvanshi, Pawan Sharma, Sarman Singh, Luc Van Kaer, and Gobardhan Das

    PNAS December 14, 2010 107 (50) 21653-21658; https://doi.org/10.1073/pnas.1007967107
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    The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

    Francesca Bellora, Roberta Castriconi, Alessandra Dondero, Giorgio Reggiardo, Lorenzo Moretta, Alberto Mantovani, Alessandro Moretta, and Cristina Bottino

    PNAS December 14, 2010 107 (50) 21659-21664; https://doi.org/10.1073/pnas.1007654108

• Medical Sciences

  • Open Access

    Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

    • Inaugural Article

    Marcin Kowanetz, Xiumin Wu, John Lee, Martha Tan, Thijs Hagenbeek, Xueping Qu, Lanlan Yu, Jed Ross, Nina Korsisaari, Tim Cao, Hani Bou-Reslan, Dara Kallop, Robby Weimer, Mary J. C. Ludlam, Joshua S. Kaminker, Zora Modrusan, Nicholas van Bruggen, Franklin V. Peale, Richard Carano, Y. Gloria Meng, and Napoleone Ferrara

    PNAS December 14, 2010 107 (50) 21248-21255; https://doi.org/10.1073/pnas.1015855107
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    Decreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-Cbl

    Jie Lu, Jeffrey Chiang, Rajiv R. Iyer, Eli Thompson, Christine R. Kaneski, David S. Xu, Chunzhang Yang, Masako Chen, Richard J. Hodes, Russell R. Lonser, Roscoe O. Brady, and Zhengping Zhuang

    PNAS December 14, 2010 107 (50) 21665-21670; https://doi.org/10.1073/pnas.1014376107
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    Target-seeking antifibrotic compound enhances wound healing and suppresses scar formation in mice

    Tero A. H. Järvinen and Erkki Ruoslahti

    PNAS December 14, 2010 107 (50) 21671-21676; https://doi.org/10.1073/pnas.1016233107
  • Open Access

    Malignant cells facilitate lung metastasis by bringing their own soil

    Dan G. Duda, Annique M. M. J. Duyverman, Mitsutomo Kohno, Matija Snuderl, Ernst J. A. Steller, Dai Fukumura, and Rakesh K. Jain

    PNAS December 14, 2010 107 (50) 21677-21682; https://doi.org/10.1073/pnas.1016234107
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    As₄S₄ targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia

    Jian-Hua Mao, Xiao-Yan Sun, Jian-Xiang Liu, Qun-Ye Zhang, Ping Liu, Qiu-Hua Huang, Keqin Kathy Li, Quan Chen, Zhu Chen, and Sai-Juan Chen

    PNAS December 14, 2010 107 (50) 21683-21688; https://doi.org/10.1073/pnas.1016311108
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    Regulation of hematopoietic stem cells by their mature progeny

    Carolyn A. de Graaf, Maria Kauppi, Tracey Baldwin, Craig D. Hyland, Donald Metcalf, Tracy A. Willson, Marina R. Carpinelli, Gordon K. Smyth, Warren S. Alexander, and Douglas J. Hilton

    PNAS December 14, 2010 107 (50) 21689-21694; https://doi.org/10.1073/pnas.1016166108
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    Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis

    George Trichonas, Yusuke Murakami, Aristomenis Thanos, Yuki Morizane, Maki Kayama, Christine M. Debouck, Toshio Hisatomi, Joan W. Miller, and Demetrios G. Vavvas

    PNAS December 14, 2010 107 (50) 21695-21700; https://doi.org/10.1073/pnas.1009179107
  • Open Access

    Global capacity for emerging infectious disease detection

    Emily H. Chan, Timothy F. Brewer, Lawrence C. Madoff, Marjorie P. Pollack, Amy L. Sonricker, Mikaela Keller, Clark C. Freifeld, Michael Blench, Abla Mawudeku, and John S. Brownstein

    PNAS December 14, 2010 107 (50) 21701-21706; https://doi.org/10.1073/pnas.1006219107
  • Open Access

    Simultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129

    John P. Mugler III, Talissa A. Altes, Iulian C. Ruset, Isabel M. Dregely, Jaime F. Mata, G. Wilson Miller, Stephen Ketel, Jeffrey Ketel, F. William Hersman, and Kai Ruppert

    PNAS December 14, 2010 107 (50) 21707-21712; https://doi.org/10.1073/pnas.1011912107
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    Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis

    Curtis J. Henry, Andriy Marusyk, Vadym Zaberezhnyy, Biniam Adane, and James DeGregori

    PNAS December 14, 2010 107 (50) 21713-21718; https://doi.org/10.1073/pnas.1005486107
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    Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia

    Kajsa Paulsson, Erik Forestier, Henrik Lilljebjörn, Jesper Heldrup, Mikael Behrendtz, Bryan D. Young, and Bertil Johansson

    PNAS December 14, 2010 107 (50) 21719-21724; https://doi.org/10.1073/pnas.1006981107
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    Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer

    Jean J. Latimer, Jennifer M. Johnson, Crystal M. Kelly, Tiffany D. Miles, Kelly A. Beaudry-Rodgers, Nancy A. Lalanne, Victor G. Vogel, Amal Kanbour-Shakir, Joseph L. Kelley, Ronald R. Johnson, and Stephen G. Grant

    PNAS December 14, 2010 107 (50) 21725-21730; https://doi.org/10.1073/pnas.0914772107
  • Open Access

    Tailor-made RNAi knockdown against triplet repeat disease-causing alleles

    Masaki Takahashi, Shoko Watanabe, Miho Murata, Hirokazu Furuya, Ichiro Kanazawa, Keiji Wada, and Hirohiko Hohjoh

    PNAS December 14, 2010 107 (50) 21731-21736; https://doi.org/10.1073/pnas.1012153107
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    Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling

    Christine M. Fillmore, Piyush B. Gupta, Jenny A. Rudnick, Silvia Caballero, Patricia J. Keller, Eric S. Lander, and Charlotte Kuperwasser

    PNAS December 14, 2010 107 (50) 21737-21742; https://doi.org/10.1073/pnas.1007863107

• Microbiology

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    Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

    Olli Aitio, Maarit Hellman, Arunas Kazlauskas, Didier F. Vingadassalom, John M. Leong, Kalle Saksela, and Perttu Permi

    PNAS December 14, 2010 107 (50) 21743-21748; https://doi.org/10.1073/pnas.1010243107
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    Microbial excavation of solid carbonates powered by P-type ATPase-mediated transcellular Ca²⁺ transport

    Ferran Garcia-Pichel, Edgardo Ramírez-Reinat, and Qunjie Gao

    PNAS December 14, 2010 107 (50) 21749-21754; https://doi.org/10.1073/pnas.1011884108
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    Large-scale identification and translocation of type IV secretion substrates by Coxiella burnetii

    Chen Chen, Simran Banga, Katja Mertens, Mary M. Weber, Ivana Gorbaslieva, Yunhao Tan, Zhao-Qing Luo, and James E. Samuel

    PNAS December 14, 2010 107 (50) 21755-21760; https://doi.org/10.1073/pnas.1010485107
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    Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis

    Rainer Kalscheuer, Brian Weinrick, Usha Veeraraghavan, Gurdyal S. Besra, and William R. Jacobs Jr.

    PNAS December 14, 2010 107 (50) 21761-21766; https://doi.org/10.1073/pnas.1014642108

• Neuroscience

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    How the brain integrates costs and benefits during decision making

    Ulrike Basten, Guido Biele, Hauke R. Heekeren, and Christian J. Fiebach

    PNAS December 14, 2010 107 (50) 21767-21772; https://doi.org/10.1073/pnas.0908104107
  • Open Access

    Amygdala regulates risk of predation in rats foraging in a dynamic fear environment

    June-Seek Choi and Jeansok J. Kim

    PNAS December 14, 2010 107 (50) 21773-21777; https://doi.org/10.1073/pnas.1010079108
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    Caveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapses

    Yukihiro Takayasu, Koichi Takeuchi, Ranju Kumari, Michael V. L. Bennett, R. Suzanne Zukin, and Anna Francesconi

    PNAS December 14, 2010 107 (50) 21778-21783; https://doi.org/10.1073/pnas.1015553107
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    Developmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learning

    Lenora Volk, Chong-Hyun Kim, Kogo Takamiya, Yilin Yu, and Richard L. Huganir

    PNAS December 14, 2010 107 (50) 21784-21789; https://doi.org/10.1073/pnas.1016103107
  • Open Access

    Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

    Bjoern Schwer, Bjoern Schumacher, David B. Lombard, Cuiying Xiao, Martin V. Kurtev, Jun Gao, Jennifer I. Schneider, Hua Chai, Roderick T. Bronson, Li-Huei Tsai, Chu-Xia Deng, and Frederick W. Alt

    PNAS December 14, 2010 107 (50) 21790-21794; https://doi.org/10.1073/pnas.1016306107
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    Sox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expression

    Christine D. Pozniak, Abraham J. Langseth, Gerrit J. P. Dijkgraaf, Youngshik Choe, Zena Werb, and Samuel J. Pleasure

    PNAS December 14, 2010 107 (50) 21795-21800; https://doi.org/10.1073/pnas.1016485107
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    Retrieval induces reconsolidation of fear extinction memory

    Janine I. Rossato, Lia R. Bevilaqua, Iván Izquierdo, Jorge H. Medina, and Martín Cammarota

    PNAS December 14, 2010 107 (50) 21801-21805; https://doi.org/10.1073/pnas.1016254107
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    Postsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivity

    Maria Lindskog, Li Li, Rachel D. Groth, Damon Poburko, Tara C. Thiagarajan, Xue Han, and Richard W. Tsien

    PNAS December 14, 2010 107 (50) 21806-21811; https://doi.org/10.1073/pnas.1016399107
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    Alzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerization

    Hyung Jin Ahn, Daria Zamolodchikov, Marta Cortes-Canteli, Erin H. Norris, J. Fraser Glickman, and Sidney Strickland

    PNAS December 14, 2010 107 (50) 21812-21817; https://doi.org/10.1073/pnas.1010373107
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    ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation

    Yong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Mei, and Tian-Ming Gao

    PNAS December 14, 2010 107 (50) 21818-21823; https://doi.org/10.1073/pnas.1010669107
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    Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with l-dopa–induced dyskinesia

    Stefania Fasano, Erwan Bezard, Angela D'Antoni, Veronica Francardo, Marzia Indrigo, Li Qin, Sandra Doveró, Milica Cerovic, M. Angela Cenci, and Riccardo Brambilla

    PNAS December 14, 2010 107 (50) 21824-21829; https://doi.org/10.1073/pnas.1012071107
  • Open Access

    Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

    Eva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann, Rainer Schneider, Calum Sutherland, and Susann Schweiger

    PNAS December 14, 2010 107 (50) 21830-21835; https://doi.org/10.1073/pnas.0912793107
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    Nicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

    Jufang Chang, Bin Zhang, Helen Heath, Niels Galjart, Xinyu Wang, and Jeffrey Milbrandt

    PNAS December 14, 2010 107 (50) 21836-21841; https://doi.org/10.1073/pnas.1002130107
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    Trial-to-trial variability of the prefrontal neurons reveals the nature of their engagement in a motion discrimination task

    Cory Hussar and Tatiana Pasternak

    PNAS December 14, 2010 107 (50) 21842-21847; https://doi.org/10.1073/pnas.1009956107
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    Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus

    Nicholas R. Wall, Ian R. Wickersham, Ali Cetin, Mauricio De La Parra, and Edward M. Callaway

    PNAS December 14, 2010 107 (50) 21848-21853; https://doi.org/10.1073/pnas.1011756107

• Pharmacology

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    α-Dystrobrevin-1 recruits α-catulin to the α_1D-adrenergic receptor/dystrophin-associated protein complex signalosome

    John S. Lyssand, Jennifer L. Whiting, Kyung-Soon Lee, Ryan Kastl, Jennifer L. Wacker, Michael R. Bruchas, Mayumi Miyatake, Lorene K. Langeberg, Charles Chavkin, John D. Scott, Richard G. Gardner, Marvin E. Adams, and Chris Hague

    PNAS December 14, 2010 107 (50) 21854-21859; https://doi.org/10.1073/pnas.1010819107

• Physiology

  • Open Access

    Shear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cells

    Yi Duan, Alan M. Weinstein, Sheldon Weinbaum, and Tong Wang

    PNAS December 14, 2010 107 (50) 21860-21865; https://doi.org/10.1073/pnas.1015751107
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    PGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber types

    Kyle A. Rasbach, Rana K. Gupta, Jorge L. Ruas, Jun Wu, Elnaz Naseri, Jennifer L. Estall, and Bruce M. Spiegelman

    PNAS December 14, 2010 107 (50) 21866-21871; https://doi.org/10.1073/pnas.1016089107
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    Deletion of hensin/DMBT1 blocks conversion of β- to α-intercalated cells and induces distal renal tubular acidosis

    XiaoBo Gao, Dominique Eladari, Francoise Leviel, Ben Yi Tew, Cristina Miró-Julià, Faisal H. Cheema, Lance Miller, Raoul Nelson, Teodor G. Păunescu, Mary McKee, Dennis Brown, and Qais Al-Awqati

    PNAS December 14, 2010 107 (50) 21872-21877; https://doi.org/10.1073/pnas.1010364107
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    Pituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthood

    Claudia Sanchez-Cardenas, Pierre Fontanaud, Zhenhe He, Chrystel Lafont, Anne-Cécile Meunier, Marie Schaeffer, Danielle Carmignac, François Molino, Nathalie Coutry, Xavier Bonnefont, Laurie-Anne Gouty-Colomer, Elodie Gavois, David J. Hodson, Paul Le Tissier, Iain C. A. F. Robinson, and Patrice Mollard

    PNAS December 14, 2010 107 (50) 21878-21883; https://doi.org/10.1073/pnas.1010849107
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    Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion

    Maureen A. Kane, Alexandra E. Folias, Attilio Pingitore, Mariarita Perri, Kristin M. Obrochta, Charles R. Krois, Erika Cione, Joo Yeon Ryu, and Joseph L. Napoli

    PNAS December 14, 2010 107 (50) 21884-21889; https://doi.org/10.1073/pnas.1008859107

• Plant Biology

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    ADP-ribosylation factor machinery mediates endocytosis in plant cells

    Satoshi Naramoto, Jürgen Kleine-Vehn, Stéphanie Robert, Masaru Fujimoto, Tomoko Dainobu, Tomasz Paciorek, Takashi Ueda, Akihiko Nakano, Marc C. E. Van Montagu, Hiroo Fukuda, and Jiří Friml

    PNAS December 14, 2010 107 (50) 21890-21895; https://doi.org/10.1073/pnas.1016260107
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    A regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunity

    Matt Humphry, Paweł Bednarek, Birgit Kemmerling, Serry Koh, Mónica Stein, Ulrike Göbel, Kurt Stüber, Mariola Piślewska-Bednarek, Ann Loraine, Paul Schulze-Lefert, Shauna Somerville, and Ralph Panstruga

    PNAS December 14, 2010 107 (50) 21896-21901; https://doi.org/10.1073/pnas.1003619107
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    An NADPH-dependent genetic switch regulates plant infection by the rice blast fungus

    Richard A. Wilson, Robert P. Gibson, Cristian F. Quispe, Jennifer A. Littlechild, and Nicholas J. Talbot

    PNAS December 14, 2010 107 (50) 21902-21907; https://doi.org/10.1073/pnas.1006839107
  • Open Access

    Repression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevity

    Raúl Carranco, José Manuel Espinosa, Pilar Prieto-Dapena, Concepción Almoguera, and Juan Jordano

    PNAS December 14, 2010 107 (50) 21908-21913; https://doi.org/10.1073/pnas.1014856107

• Psychological and Cognitive Sciences

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    Effects of oxytocin on recollections of maternal care and closeness

    Jennifer A. Bartz, Jamil Zaki, Kevin N. Ochsner, Niall Bolger, Alexander Kolevzon, Natasha Ludwig, and John E. Lydon

    PNAS December 14, 2010 107 (50) 21371-21375; https://doi.org/10.1073/pnas.1012669107
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    Rapid efficient coding of correlated complex acoustic properties

    Christian E. Stilp, Timothy T. Rogers, and Keith R. Kluender

    PNAS December 14, 2010 107 (50) 21914-21919; https://doi.org/10.1073/pnas.1009020107
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    Topological change disturbs object continuity in attentive tracking

    Ke Zhou, Huan Luo, Tiangang Zhou, Yan Zhuo, and Lin Chen

    PNAS December 14, 2010 107 (50) 21920-21924; https://doi.org/10.1073/pnas.1010919108

• Sustainability Science

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    Forest responses to increasing aridity and warmth in the southwestern United States

    A. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt

    PNAS December 14, 2010 107 (50) 21289-21294; https://doi.org/10.1073/pnas.0914211107
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    Cost-effectiveness of dryland forest restoration evaluated by spatial analysis of ecosystem services

    Jennifer C. Birch, Adrian C. Newton, Claudia Alvarez Aquino, Elena Cantarello, Cristian Echeverría, Thomas Kitzberger, Ignacio Schiappacasse, and Natalia Tejedor Garavito

    PNAS December 14, 2010 107 (50) 21925-21930; https://doi.org/10.1073/pnas.1003369107

• Systems Biology

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    Histone H3K27ac separates active from poised enhancers and predicts developmental state

    • From the Cover

    Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead, Tristan Kooistra, Bryce W. Carey, Eveline J. Steine, Jacob Hanna, Michael A. Lodato, Garrett M. Frampton, Phillip A. Sharp, Laurie A. Boyer, Richard A. Young, and Rudolf Jaenisch

    PNAS December 14, 2010 107 (50) 21931-21936; https://doi.org/10.1073/pnas.1016071107

    See companion article:

    • Unraveling the score of the enhancer symphony

      - Dec 06, 2010
  • Open Access

    DNA damage regulates the mobility of Brca2 within the nucleoplasm of living cells

    Anand D. Jeyasekharan, Nabieh Ayoub, Robert Mahen, Jonas Ries, Alessandro Esposito, Eeson Rajendra, Hiroyoshi Hattori, Rajan P. Kulkarni, and Ashok R. Venkitaraman

    PNAS December 14, 2010 107 (50) 21937-21942; https://doi.org/10.1073/pnas.1009577107