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Table of Contents
December 14, 2010; vol. 107 no. 50
This Week in PNAS
Letters (Online Only)
- You have accessReply to Harris and Chan: Moral judgment is more than rational deliberationMolly J. Crockett, Luke Clark, Marc D. Hauser, and Trevor W. Robbins
Editorial
Climate Change and Water in Southwestern North America Special Feature (free online)
Perspectives
- You have accessWater, climate change, and sustainability in the southwest
- From the Cover
Glen M. MacDonald - You have accessReclaiming freshwater sustainability in the Cadillac DesertJohn L. Sabo, Tushar Sinha, Laura C. Bowling, Gerrit H. W. Schoups, Wesley W. Wallender, Michael E. Campana, Keith A. Cherkauer, Pam L. Fuller, William L. Graf, Jan W. Hopmans, John S. Kominoski, Carissa Taylor, Stanley W. Trimble, Robert H. Webb, and Ellen E. Wohl
- You have accessRoadmap for sustainable water resources in southwestern North AmericaPeter H. Gleick
Research Articles
- You have accessFuture dryness in the southwest US and the hydrology of the early 21st century droughtDaniel R. Cayan, Tapash Das, David W. Pierce, Tim P. Barnett, Mary Tyree, and Alexander Gershunov
- You have accessGreenhouse warming and the 21st century hydroclimate of southwestern North AmericaRichard Seager and Gabriel A. Vecchi
- You have accessA 1,200-year perspective of 21st century drought in southwestern North AmericaConnie A. Woodhouse, David M. Meko, Glen M. MacDonald, Dave W. Stahle, and Edward R. Cook
- You have accessForest responses to increasing aridity and warmth in the southwestern United StatesA. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt
- You have accessVulnerability assessment of climate-induced water shortage in PhoenixPatricia Gober and Craig W. Kirkwood
Physical Sciences
Applied Physical Sciences
- You have accessLuminescent nanocrystal stress gaugeCharina L. Choi, Kristie J. Koski, Andrew C. K. Olson, and A. Paul Alivisatos
- You have accessOrganization of the polarization splay modulated smectic liquid crystal phase by topographic confinementDong Ki Yoon, Rajdeep Deb, Dong Chen, Eva Körblova, Renfan Shao, Ken Ishikawa, Nandiraju V. S. Rao, David M. Walba, Ivan I. Smalyukh, and Noel A. Clark
Chemistry
- You have accessIn vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporterGenevieve C. Van de Bittner, Elena A. Dubikovskaya, Carolyn R. Bertozzi, and Christopher J. Chang
- You have accessAnabaena sensory rhodopsin is a light-driven unidirectional rotorAngela Strambi, Bo Durbeej, Nicolas Ferré, and Massimo Olivucci
- You have accessStructural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymeraseSamra Obeid, Anna Baccaro, Wolfram Welte, Kay Diederichs, and Andreas Marx
- You have accessRotational and constitutional dynamics of caged supramoleculesDirk Kühne, Florian Klappenberger, Wolfgang Krenner, Svetlana Klyatskaya, Mario Ruben, and Johannes V. Barth
- You have accessMechanism of action and inhibition of dehydrosqualene synthaseFu-Yang Lin, Chia-I Liu, Yi-Liang Liu, Yonghui Zhang, Ke Wang, Wen-Yih Jeng, Tzu-Ping Ko, Rong Cao, Andrew H.-J. Wang, and Eric Oldfield
- You have accessFree energy profiles from single-molecule pulling experimentsGerhard Hummer and Attila Szabo
- You have accessEffects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17Candace M. Pfefferkorn, Ryan P. McGlinchey, and Jennifer C. Lee
- You have accessRelaxation mechanisms of UV-photoexcited DNA and RNA nucleobasesMario Barbatti, Adélia J. A. Aquino, Jaroslaw J. Szymczak, Dana Nachtigallová, Pavel Hobza, and Hans Lischka
- You have accessDry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wiresGovardhan Reddy, John E. Straub, and D. Thirumalai
- You have accessRecognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assemblyOlli Aitio, Maarit Hellman, Arunas Kazlauskas, Didier F. Vingadassalom, John M. Leong, Kalle Saksela, and Perttu Permi
Engineering
- Open AccessShear stress-induced changes of membrane transporter localization and expression in mouse proximal tubule cellsYi Duan, Alan M. Weinstein, Sheldon Weinbaum, and Tong Wang
Environmental Sciences
- You have accessGreenhouse warming and the 21st century hydroclimate of southwestern North AmericaRichard Seager and Gabriel A. Vecchi
- You have accessRapid landscape transformation in South Island, New Zealand, following initial Polynesian settlement
- From the Cover
David B. McWethy, Cathy Whitlock, Janet M. Wilmshurst, Matt S. McGlone, Mairie Fromont, Xun Li, Ann Dieffenbacher-Krall, William O. Hobbs, Sherilyn C. Fritz, and Edward R. CookSee companion article:
- Open AccessConsiderations for parameter optimization and sensitivity in climate modelsJ. David Neelin, Annalisa Bracco, Hao Luo, James C. McWilliams, and Joyce E. Meyerson
- You have accessMicrobial excavation of solid carbonates powered by P-type ATPase-mediated transcellular Ca2+ transportFerran Garcia-Pichel, Edgardo Ramírez-Reinat, and Qunjie Gao
Geology
- You have accessAntarctic lakes suggest millennial reorganizations of Southern Hemisphere atmospheric and oceanic circulationBrenda L. Hall, George H. Denton, Andrew G. Fountain, Chris H. Hendy, and Gideon M. Henderson
Geophysics
- You have accessContribution of isoprene-derived organosulfates to free tropospheric aerosol massK. D. Froyd, S. M. Murphy, D. M. Murphy, J. A. de Gouw, N. C. Eddingsaas, and P. O. Wennberg
Physics
- You have accessSelf-organization, condensation, and annihilation of topological vortices and antivortices in a multiferroicS. C. Chae, Y. Horibe, D. Y. Jeong, S. Rodan, N. Lee, and S.-W. Cheong
Sustainability Science
- You have accessFuture dryness in the southwest US and the hydrology of the early 21st century droughtDaniel R. Cayan, Tapash Das, David W. Pierce, Tim P. Barnett, Mary Tyree, and Alexander Gershunov
- You have accessA 1,200-year perspective of 21st century drought in southwestern North AmericaConnie A. Woodhouse, David M. Meko, Glen M. MacDonald, Dave W. Stahle, and Edward R. Cook
Social Sciences
Psychological and Cognitive Sciences
- You have accessEffects of oxytocin on recollections of maternal care and closenessJennifer A. Bartz, Jamil Zaki, Kevin N. Ochsner, Niall Bolger, Alexander Kolevzon, Natasha Ludwig, and John E. Lydon
- You have accessHow the brain integrates costs and benefits during decision makingUlrike Basten, Guido Biele, Hauke R. Heekeren, and Christian J. Fiebach
- Open AccessAmygdala regulates risk of predation in rats foraging in a dynamic fear environmentJune-Seek Choi and Jeansok J. Kim
- You have accessRapid efficient coding of correlated complex acoustic propertiesChristian E. Stilp, Timothy T. Rogers, and Keith R. Kluender
Sustainability Science
- You have accessVulnerability assessment of climate-induced water shortage in PhoenixPatricia Gober and Craig W. Kirkwood
Biological Sciences
Anthropology
- You have accessEffects of Pleistocene glaciations and rivers on the population structure of Bornean orangutans (Pongo pygmaeus)Natasha Arora, Alexander Nater, Carel P. van Schaik, Erik P. Willems, Maria A. van Noordwijk, Benoit Goossens, Nadja Morf, Meredith Bastian, Cheryl Knott, Helen Morrogh-Bernard, Noko Kuze, Tomoko Kanamori, Joko Pamungkas, Dyah Perwitasari-Farajallah, Ernst Verschoor, Kristin Warren, and Michael Krützen
Biochemistry
- You have accessIn vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporterGenevieve C. Van de Bittner, Elena A. Dubikovskaya, Carolyn R. Bertozzi, and Christopher J. Chang
- You have accessUNC-45/CRO1/She4p (UCS) protein forms elongated dimer and joins two myosin heads near their actin binding regionHang Shi and Günter Blobel
- You have accessCation-π interaction regulates ligand-binding affinity and signaling of integrin α4β7YouDong Pan, Kun Zhang, JunPeng Qi, Jiao Yue, Timothy A. Springer, and JianFeng Chen
- You have accessStrategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosisJared R. Auclair, Kristin J. Boggio, Gregory A. Petsko, Dagmar Ringe, and Jeffrey N. Agar
- You have accessStructural identification of cation binding pockets in the plasma membrane proton pumpKira Ekberg, Bjørn P. Pedersen, Danny M. Sørensen, Ann K. Nielsen, Bjarke Veierskov, Poul Nissen, Michael G. Palmgren, and Morten J. Buch-Pedersen
- You have accessCrystal structure of a 117 kDa glucansucrase fragment provides insight into evolution and product specificity of GH70 enzymesAndreja Vujičić-Žagar, Tjaard Pijning, Slavko Kralj, Cesar A. López, Wieger Eeuwema, Lubbert Dijkhuizen, and Bauke W. Dijkstra
- Open AccessDirected epitope delivery across the Escherichia coli outer membrane through the porin OmpFNicholas G. Housden, Justyna A. Wojdyla, Justyna Korczynska, Irina Grishkovskaya, Nadine Kirkpatrick, A. Marek Brzozowski, and Colin Kleanthous
- You have accessHelicobacter pylori proinflammatory protein up-regulates NF-κB as a cell-translocating Ser/Thr kinaseDo Jin Kim, Kang-Seo Park, Jung-Ho Kim, Sang-Hwa Yang, Ji Young Yoon, Byeong-Gu Han, Hyoun Sook Kim, Sang Jae Lee, Jun Young Jang, Kyoung Hoon Kim, Mi Jung Kim, Jin-Su Song, Hie-Joon Kim, Chung-Mo Park, Sang-Kyou Lee, Byung Il Lee, and Se Won Suh
- Open AccessIdentification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesisJoon No Lee, Hyeonwoo Kim, Hongbing Yao, Yan Chen, Kayson Weng, and Jin Ye
- You have accessTargeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machineryXue-Ming Xu, Anton A. Turanov, Bradley A. Carlson, Min-Hyuk Yoo, Robert A. Everley, Renu Nandakumar, Irina Sorokina, Steven P. Gygi, Vadim N. Gladyshev, and Dolph L. Hatfield
- You have accessActivation and intrinsic γ-secretase activity of presenilin 1
- From the Cover
Kwangwook Ahn, Christopher C. Shelton, Yuan Tian, Xulun Zhang, M. Lane Gilchrist, Sangram S. Sisodia, and Yue-Ming LiSee companion article:
Biophysics and Computational Biology
- You have accessAnabaena sensory rhodopsin is a light-driven unidirectional rotorAngela Strambi, Bo Durbeej, Nicolas Ferré, and Massimo Olivucci
- You have accessStructural basis for the synthesis of nucleobase modified DNA by Thermus aquaticus DNA polymeraseSamra Obeid, Anna Baccaro, Wolfram Welte, Kay Diederichs, and Andreas Marx
- You have accessFree energy profiles from single-molecule pulling experimentsGerhard Hummer and Attila Szabo
- You have accessEffects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17Candace M. Pfefferkorn, Ryan P. McGlinchey, and Jennifer C. Lee
- You have accessRelaxation mechanisms of UV-photoexcited DNA and RNA nucleobasesMario Barbatti, Adélia J. A. Aquino, Jaroslaw J. Szymczak, Dana Nachtigallová, Pavel Hobza, and Hans Lischka
- You have accessDry amyloid fibril assembly in a yeast prion peptide is mediated by long-lived structures containing water wiresGovardhan Reddy, John E. Straub, and D. Thirumalai
- You have accessRelationship between Ca2+-affinity and shielding of bulk water in the Ca2+-pump from molecular dynamics simulationsYuji Sugita, Mitsunori Ikeguchi, and Chikashi Toyoshima
- You have accessInterheme electron tunneling in cytochrome c oxidaseVille R. I. Kaila, Mikael P. Johansson, Dage Sundholm, and Mårten Wikström
- You have accessProtein structure determination by exhaustive search of Protein Data Bank derived databasesIan Stokes-Rees and Piotr Sliz
- Open AccessDivalent counterion-induced condensation of triple-strand DNAXiangyun Qiu, V. Adrian Parsegian, and Donald C. Rau
- You have accessIdentification of differential translation in genome wide studiesOla Larsson, Nahum Sonenberg, and Robert Nadon
- You have accessDeconvolution of dynamic mechanical networksMichael Hinczewski, Yann von Hansen, and Roland R. Netz
Cell Biology
- You have accessReversible methylation of promoter-bound STAT3 by histone-modifying enzymesJinbo Yang, Jing Huang, Maupali Dasgupta, Nathan Sears, Masaru Miyagi, Benlian Wang, Mark R. Chance, Xing Chen, Yuping Du, Yuxin Wang, Lizhe An, Qin Wang, Tao Lu, Xiaodong Zhang, Zhenghe Wang, and George R. Stark
- You have accessMicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsetsA. G. Lisa Ooi, Debashis Sahoo, Maddalena Adorno, Yulei Wang, Irving L. Weissman, and Christopher Y. Park
- Open AccessSelective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculiGenevieve Ko, Summer Paradise, Hong Chen, Morven Graham, Manuela Vecchi, Fabrizio Bianchi, Ottavio Cremona, Pier Paolo Di Fiore, and Pietro De Camilli
- You have accessThe major α-tubulin K40 acetyltransferase αTAT1 promotes rapid ciliogenesis and efficient mechanosensationToshinobu Shida, Juan G. Cueva, Zhenjie Xu, Miriam B. Goodman, and Maxence V. Nachury
See companion article:
- You have accessA vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulumSheung Kwan Lam, Naofumi Yoda, and Randy Schekman
See companion article:
- You have accessHoxb4 transduction down-regulates Geminin protein, providing hematopoietic stem and progenitor cells with proliferation potentialYoshinori Ohno, Shin'ichiro Yasunaga, Motoaki Ohtsubo, Sayaka Mori, Miyuki Tsumura, Satoshi Okada, Tomohiko Ohta, Kiyoshi Ohtani, Masao Kobayashi, and Yoshihiro Takihara
- Open AccessPathology tissue–chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samplesMirco Fanelli, Stefano Amatori, Iros Barozzi, Matias Soncini, Roberto Dal Zuffo, Gabriele Bucci, Maria Capra, Micaela Quarto, Gaetano Ivan Dellino, Ciro Mercurio, Myriam Alcalay, Giuseppe Viale, Pier Giuseppe Pelicci, and Saverio Minucci
- You have accessSpecific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1Melanie Stumpf, Xiaojing Yue, Sandra Schmitz, Hervé Luche, Janardan K. Reddy, and Tilman Borggrefe
- You have accessProfilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cellsYong Ho Bae, Zhijie Ding, Tuhin Das, Alan Wells, Frank Gertler, and Partha Roy
- Open AccessKIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agentsKazunori Yoshikiyo, Katja Kratz, Kouji Hirota, Kana Nishihara, Minoru Takata, Hitoshi Kurumizaka, Satoshi Horimoto, Shunichi Takeda, and Josef Jiricny
Developmental Biology
- You have accessMicroRNA miR-125b causes leukemiaMarina Bousquet, Marian H. Harris, Beiyan Zhou, and Harvey F. Lodish
- You have accessβ-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switchingDavid Enshell-Seijffers, Catherine Lindon, Eleanor Wu, Makoto M. Taketo, and Bruce A. Morgan
Ecology
- You have accessForest responses to increasing aridity and warmth in the southwestern United StatesA. Park Williams, Craig D. Allen, Constance I. Millar, Thomas W. Swetnam, Joel Michaelsen, Christopher J. Still, and Steven W. Leavitt
Environmental Sciences
- You have accessRapid landscape transformation in South Island, New Zealand, following initial Polynesian settlement
- From the Cover
David B. McWethy, Cathy Whitlock, Janet M. Wilmshurst, Matt S. McGlone, Mairie Fromont, Xun Li, Ann Dieffenbacher-Krall, William O. Hobbs, Sherilyn C. Fritz, and Edward R. CookSee companion article:
Evolution
- You have accessSource identification in two criminal cases using phylogenetic analysis of HIV-1 DNA sequences
- Inaugural Article
Diane I. Scaduto, Jeremy M. Brown, Wade C. Haaland, Derrick J. Zwickl, David M. Hillis, and Michael L. MetzkerSee companion article:
- Profile of David M. Hillis- Jun 13, 2011
- You have accessNeuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat SpalaxAaron Avivi, Frank Gerlach, Alma Joel, Stefan Reuss, Thorsten Burmester, Eviatar Nevo, and Thomas Hankeln
- You have accessGorgeous mosaic of mitochondrial genes created by horizontal transfer and gene conversionWeilong Hao, Aaron O. Richardson, Yihong Zheng, and Jeffrey D. Palmer
- You have accessEncephalization is not a universal macroevolutionary phenomenon in mammals but is associated with socialitySusanne Shultz and Robin Dunbar
- You have accessHeritable victimization and the benefits of agonistic relationshipsAmanda J. Lea, Daniel T. Blumstein, Tina W. Wey, and Julien G. A. Martin
- You have accessEvolution of an antifreeze protein by neofunctionalization under escape from adaptive conflictCheng Deng, C.-H. Christina Cheng, Hua Ye, Ximiao He, and Liangbiao Chen
- You have accessTransspecies dimorphic allelic lineages of the proteasome subunit β-type 8 gene (PSMB8) in the teleost genus OryziasFumi Miura, Kentaro Tsukamoto, Ratnesh Bhai Mehta, Kiyoshi Naruse, Wichian Magtoon, and Masaru Nonaka
Genetics
- You have accessCheckpoint genes and Exo1 regulate nearby inverted repeat fusions that form dicentric chromosomes in Saccharomyces cerevisiaeSalma Kaochar, Lisa Shanks, and Ted Weinert
- You have accessGenome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genomeJames Cockram, Jon White, Diana L. Zuluaga, David Smith, Jordi Comadran, Malcolm Macaulay, Zewei Luo, Mike J. Kearsey, Peter Werner, David Harrap, Chris Tapsell, Hui Liu, Peter E. Hedley, Nils Stein, Daniela Schulte, Burkhard Steuernagel, David F. Marshall, William T. B. Thomas, Luke Ramsay, Ian Mackay, David J. Balding, The AGOUEB Consortium, Robbie Waugh, and Donal M. O'Sullivan
- You have accessRegulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factorsRobert Morbitzer, Patrick Römer, Jens Boch, and Thomas Lahaye
- You have accessJumonji domain protein JMJD5 functions in both the plant and human circadian systemsMatthew A. Jones, Michael F. Covington, Luciano DiTacchio, Christopher Vollmers, Satchidananda Panda, and Stacey L. Harmer
Immunology
- You have accessDicer controls CD8+ T-cell activation, migration, and survivalNu Zhang and Michael J. Bevan
- You have accessInflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4Bo Hu, Eran Elinav, Samuel Huber, Carmen J. Booth, Till Strowig, Chengcheng Jin, Stephanie C. Eisenbarth, and Richard A. Flavell
- You have accessViral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppressionAndreas Bergthaler, Lukas Flatz, Ahmed N. Hegazy, Susan Johnson, Edit Horvath, Max Löhning, and Daniel D. Pinschewer
- You have accessMature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Rα complexesKutlu G. Elpek, Mark P. Rubinstein, Angelique Bellemare-Pelletier, Ananda W. Goldrath, and Shannon J. Turley
- You have accessMycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cellsShilpa Raghuvanshi, Pawan Sharma, Sarman Singh, Luc Van Kaer, and Gobardhan Das
- You have accessThe interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomesFrancesca Bellora, Roberta Castriconi, Alessandra Dondero, Giorgio Reggiardo, Lorenzo Moretta, Alberto Mantovani, Alessandro Moretta, and Cristina Bottino
Medical Sciences
- Open AccessGranulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes
- Inaugural Article
Marcin Kowanetz, Xiumin Wu, John Lee, Martha Tan, Thijs Hagenbeek, Xueping Qu, Lanlan Yu, Jed Ross, Nina Korsisaari, Tim Cao, Hani Bou-Reslan, Dara Kallop, Robby Weimer, Mary J. C. Ludlam, Joshua S. Kaminker, Zora Modrusan, Nicholas van Bruggen, Franklin V. Peale, Richard Carano, Y. Gloria Meng, and Napoleone Ferrara - You have accessDecreased glucocerebrosidase activity in Gaucher disease parallels quantitative enzyme loss due to abnormal interaction with TCP1 and c-CblJie Lu, Jeffrey Chiang, Rajiv R. Iyer, Eli Thompson, Christine R. Kaneski, David S. Xu, Chunzhang Yang, Masako Chen, Richard J. Hodes, Russell R. Lonser, Roscoe O. Brady, and Zhengping Zhuang
- You have accessTarget-seeking antifibrotic compound enhances wound healing and suppresses scar formation in miceTero A. H. Järvinen and Erkki Ruoslahti
- Open AccessMalignant cells facilitate lung metastasis by bringing their own soilDan G. Duda, Annique M. M. J. Duyverman, Mitsutomo Kohno, Matija Snuderl, Ernst J. A. Steller, Dai Fukumura, and Rakesh K. Jain
- You have accessAs4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemiaJian-Hua Mao, Xiao-Yan Sun, Jian-Xiang Liu, Qun-Ye Zhang, Ping Liu, Qiu-Hua Huang, Keqin Kathy Li, Quan Chen, Zhu Chen, and Sai-Juan Chen
- You have accessRegulation of hematopoietic stem cells by their mature progenyCarolyn A. de Graaf, Maria Kauppi, Tracey Baldwin, Craig D. Hyland, Donald Metcalf, Tracy A. Willson, Marina R. Carpinelli, Gordon K. Smyth, Warren S. Alexander, and Douglas J. Hilton
- You have accessReceptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosisGeorge Trichonas, Yusuke Murakami, Aristomenis Thanos, Yuki Morizane, Maki Kayama, Christine M. Debouck, Toshio Hisatomi, Joan W. Miller, and Demetrios G. Vavvas
- Open AccessGlobal capacity for emerging infectious disease detectionEmily H. Chan, Timothy F. Brewer, Lawrence C. Madoff, Marjorie P. Pollack, Amy L. Sonricker, Mikaela Keller, Clark C. Freifeld, Michael Blench, Abla Mawudeku, and John S. Brownstein
- Open AccessSimultaneous magnetic resonance imaging of ventilation distribution and gas uptake in the human lung using hyperpolarized xenon-129John P. Mugler III, Talissa A. Altes, Iulian C. Ruset, Isabel M. Dregely, Jaime F. Mata, G. Wilson Miller, Stephen Ketel, Jeffrey Ketel, F. William Hersman, and Kai Ruppert
- You have accessDeclining lymphoid progenitor fitness promotes aging-associated leukemogenesisCurtis J. Henry, Andriy Marusyk, Vadym Zaberezhnyy, Biniam Adane, and James DeGregori
- You have accessGenetic landscape of high hyperdiploid childhood acute lymphoblastic leukemiaKajsa Paulsson, Erik Forestier, Henrik Lilljebjörn, Jesper Heldrup, Mikael Behrendtz, Bryan D. Young, and Bertil Johansson
- You have accessNucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancerJean J. Latimer, Jennifer M. Johnson, Crystal M. Kelly, Tiffany D. Miles, Kelly A. Beaudry-Rodgers, Nancy A. Lalanne, Victor G. Vogel, Amal Kanbour-Shakir, Joseph L. Kelley, Ronald R. Johnson, and Stephen G. Grant
- Open AccessTailor-made RNAi knockdown against triplet repeat disease-causing allelesMasaki Takahashi, Shoko Watanabe, Miho Murata, Hirokazu Furuya, Ichiro Kanazawa, Keiji Wada, and Hirohiko Hohjoh
- You have accessEstrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signalingChristine M. Fillmore, Piyush B. Gupta, Jenny A. Rudnick, Silvia Caballero, Patricia J. Keller, Eric S. Lander, and Charlotte Kuperwasser
Microbiology
- You have accessRecognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assemblyOlli Aitio, Maarit Hellman, Arunas Kazlauskas, Didier F. Vingadassalom, John M. Leong, Kalle Saksela, and Perttu Permi
- You have accessMicrobial excavation of solid carbonates powered by P-type ATPase-mediated transcellular Ca2+ transportFerran Garcia-Pichel, Edgardo Ramírez-Reinat, and Qunjie Gao
- You have accessLarge-scale identification and translocation of type IV secretion substrates by Coxiella burnetiiChen Chen, Simran Banga, Katja Mertens, Mary M. Weber, Ivana Gorbaslieva, Yunhao Tan, Zhao-Qing Luo, and James E. Samuel
- You have accessTrehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosisRainer Kalscheuer, Brian Weinrick, Usha Veeraraghavan, Gurdyal S. Besra, and William R. Jacobs Jr.
Neuroscience
- You have accessHow the brain integrates costs and benefits during decision makingUlrike Basten, Guido Biele, Hauke R. Heekeren, and Christian J. Fiebach
- Open AccessAmygdala regulates risk of predation in rats foraging in a dynamic fear environmentJune-Seek Choi and Jeansok J. Kim
- You have accessCaveolin-1 knockout mice exhibit impaired induction of mGluR-dependent long-term depression at CA3-CA1 synapsesYukihiro Takayasu, Koichi Takeuchi, Ranju Kumari, Michael V. L. Bennett, R. Suzanne Zukin, and Anna Francesconi
- You have accessDevelopmental regulation of protein interacting with C kinase 1 (PICK1) function in hippocampal synaptic plasticity and learningLenora Volk, Chong-Hyun Kim, Kogo Takamiya, Yilin Yu, and Richard L. Huganir
- Open AccessNeural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesityBjoern Schwer, Bjoern Schumacher, David B. Lombard, Cuiying Xiao, Martin V. Kurtev, Jun Gao, Jennifer I. Schneider, Hua Chai, Roderick T. Bronson, Li-Huei Tsai, Chu-Xia Deng, and Frederick W. Alt
- You have accessSox10 directs neural stem cells toward the oligodendrocyte lineage by decreasing Suppressor of Fused expressionChristine D. Pozniak, Abraham J. Langseth, Gerrit J. P. Dijkgraaf, Youngshik Choe, Zena Werb, and Samuel J. Pleasure
- You have accessRetrieval induces reconsolidation of fear extinction memoryJanine I. Rossato, Lia R. Bevilaqua, Iván Izquierdo, Jorge H. Medina, and Martín Cammarota
- You have accessPostsynaptic GluA1 enables acute retrograde enhancement of presynaptic function to coordinate adaptation to synaptic inactivityMaria Lindskog, Li Li, Rachel D. Groth, Damon Poburko, Tara C. Thiagarajan, Xue Han, and Richard W. Tsien
- You have accessAlzheimer's disease peptide β-amyloid interacts with fibrinogen and induces its oligomerizationHyung Jin Ahn, Daria Zamolodchikov, Marta Cortes-Canteli, Erin H. Norris, J. Fraser Glickman, and Sidney Strickland
- You have accessErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiationYong-Jun Chen, Meng Zhang, Dong-Min Yin, Lei Wen, Annie Ting, Pu Wang, Yi-Sheng Lu, Xin-Hong Zhu, Shu-Ji Li, Cui-Ying Wu, Xue-Ming Wang, Cary Lai, Wen-Cheng Xiong, Lin Mei, and Tian-Ming Gao
- You have accessInhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with l-dopa–induced dyskinesiaStefania Fasano, Erwan Bezard, Angela D'Antoni, Veronica Francardo, Marzia Indrigo, Li Qin, Sandra Doveró, Milica Cerovic, M. Angela Cenci, and Riccardo Brambilla
- Open AccessBiguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signalingEva Kickstein, Sybille Krauss, Paul Thornhill, Désirée Rutschow, Raphael Zeller, John Sharkey, Ritchie Williamson, Melanie Fuchs, Andrea Köhler, Hartmut Glossmann, Rainer Schneider, Calum Sutherland, and Susann Schweiger
- You have accessNicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locusJufang Chang, Bin Zhang, Helen Heath, Niels Galjart, Xinyu Wang, and Jeffrey Milbrandt
- You have accessTrial-to-trial variability of the prefrontal neurons reveals the nature of their engagement in a motion discrimination taskCory Hussar and Tatiana Pasternak
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Pharmacology
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Physiology
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- You have accessPGC-1α regulates a HIF2α-dependent switch in skeletal muscle fiber typesKyle A. Rasbach, Rana K. Gupta, Jorge L. Ruas, Jun Wu, Elnaz Naseri, Jennifer L. Estall, and Bruce M. Spiegelman
- You have accessDeletion of hensin/DMBT1 blocks conversion of β- to α-intercalated cells and induces distal renal tubular acidosisXiaoBo Gao, Dominique Eladari, Francoise Leviel, Ben Yi Tew, Cristina Miró-Julià, Faisal H. Cheema, Lance Miller, Raoul Nelson, Teodor G. Păunescu, Mary McKee, Dennis Brown, and Qais Al-Awqati
- You have accessPituitary growth hormone network responses are sexually dimorphic and regulated by gonadal steroids in adulthoodClaudia Sanchez-Cardenas, Pierre Fontanaud, Zhenhe He, Chrystel Lafont, Anne-Cécile Meunier, Marie Schaeffer, Danielle Carmignac, François Molino, Nathalie Coutry, Xavier Bonnefont, Laurie-Anne Gouty-Colomer, Elodie Gavois, David J. Hodson, Paul Le Tissier, Iain C. A. F. Robinson, and Patrice Mollard
- You have accessIdentification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretionMaureen A. Kane, Alexandra E. Folias, Attilio Pingitore, Mariarita Perri, Kristin M. Obrochta, Charles R. Krois, Erika Cione, Joo Yeon Ryu, and Joseph L. Napoli
Plant Biology
- You have accessADP-ribosylation factor machinery mediates endocytosis in plant cellsSatoshi Naramoto, Jürgen Kleine-Vehn, Stéphanie Robert, Masaru Fujimoto, Tomoko Dainobu, Tomasz Paciorek, Takashi Ueda, Akihiko Nakano, Marc C. E. Van Montagu, Hiroo Fukuda, and Jiří Friml
- You have accessA regulon conserved in monocot and dicot plants defines a functional module in antifungal plant immunityMatt Humphry, Paweł Bednarek, Birgit Kemmerling, Serry Koh, Mónica Stein, Ulrike Göbel, Kurt Stüber, Mariola Piślewska-Bednarek, Ann Loraine, Paul Schulze-Lefert, Shauna Somerville, and Ralph Panstruga
- You have accessAn NADPH-dependent genetic switch regulates plant infection by the rice blast fungusRichard A. Wilson, Robert P. Gibson, Cristian F. Quispe, Jennifer A. Littlechild, and Nicholas J. Talbot
- Open AccessRepression by an auxin/indole acetic acid protein connects auxin signaling with heat shock factor-mediated seed longevityRaúl Carranco, José Manuel Espinosa, Pilar Prieto-Dapena, Concepción Almoguera, and Juan Jordano
Psychological and Cognitive Sciences
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Sustainability Science
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- You have accessCost-effectiveness of dryland forest restoration evaluated by spatial analysis of ecosystem servicesJennifer C. Birch, Adrian C. Newton, Claudia Alvarez Aquino, Elena Cantarello, Cristian Echeverría, Thomas Kitzberger, Ignacio Schiappacasse, and Natalia Tejedor Garavito
Systems Biology
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- From the Cover
Menno P. Creyghton, Albert W. Cheng, G. Grant Welstead, Tristan Kooistra, Bryce W. Carey, Eveline J. Steine, Jacob Hanna, Michael A. Lodato, Garrett M. Frampton, Phillip A. Sharp, Laurie A. Boyer, Richard A. Young, and Rudolf JaenischSee companion article:
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