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Commentary

And four equals one: Presenilin takes the γ-secretase role by itself

Christian B. Lessard, Steven L. Wagner, and Edward H. Koo
  1. Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093

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PNAS December 14, 2010 107 (50) 21236-21237; https://doi.org/10.1073/pnas.1016284108
Christian B. Lessard
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Steven L. Wagner
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Edward H. Koo
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  • For correspondence: edkoo@ucsd.edu
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Online Impact

 

Article Information

vol. 107 no. 50 21236-21237
DOI: 
https://doi.org/10.1073/pnas.1016284108
PubMed: 
21135249

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue December 14, 2010.
  • Published first December 6, 2010.

Article Versions

  • Previous version (December 6, 2010 - 12:37).
  • You are viewing the most recent version of this article.

Author Information

  1. Christian B. Lessard,
  2. Steven L. Wagner, and
  3. Edward H. Koo1
  1. Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093

Footnotes

  • 1To whom correspondence should be addressed. E-mail: edkoo{at}ucsd.edu.
  • Author contributions: C.B.L, S.L.W., and E.H.K. wrote the paper.

  • The authors declare no conflict of interest.

  • See companion article on page 21435.

Cited By...

  • 11 Citations
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    Molecular Brain 2018 11 1
  • γ-Secretase and its modulators: Twenty years and beyond
    Weiming Xia
    Neuroscience Letters 2019 701
  • Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells
    Christian B. Lessard, Edgardo Rodriguez, Thomas B. Ladd, Lisa M. Minter, Barbara A. Osborne, Lucio Miele, Todd E. Golde, Yong Ran
    Journal of Biological Chemistry 2019 294 29
  • Clinical and molecular studies reveal a PSEN1 mutation (L153V) in a Peruvian family with early-onset Alzheimer's disease
    Mario R. Cornejo-Olivas, Chang-En Yu, Pilar Mazzetti, Ignacio F. Mata, Maria Meza, Saul Lindo-Samanamud, James B. Leverenz, Thomas D. Bird
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Article usage

Article usage: December 2010 to April 2021

AbstractFullPdf
Dec 201059173387
Total 201059173387
Jan 20112114381
Feb 2011114324
Mar 2011124326
Apr 201122316
May 2011492421
Jun 2011151620
Jul 201120139
Aug 201110108
Sep 20112778
Oct 201122117
Nov 201127510
Dec 20111372
Total 2011229345232
Jan 201224610
Feb 2012241210
Mar 20121362
Apr 201211138
May 20122154
Jun 2012101512
Jul 2012885
Aug 20122197
Sep 2012551
Oct 201215145
Nov 20122455
Dec 201217108
Total 201219310877
Jan 201318210
Feb 201323611
Mar 20131337
Apr 2013228
May 2013048
Jun 20131977
Jul 20132457
Aug 20131326
Sep 20131456
Oct 20132227
Nov 201312610
Dec 20131379
Total 20131735196
Jan 20142075
Feb 20141701
Mar 20142267
Apr 20141214
May 2014785
Jun 2014935
Jul 20141211
Aug 201419144
Sep 20142272
Oct 20142085
Nov 2014535
Dec 2014967
Total 20141746451
Jan 2015721
Feb 2015914
Mar 20151123
Apr 20151222
May 20151014
Jun 2015811
Jul 2015833
Aug 2015967
Sep 20151921
Oct 2015632
Nov 2015530
Dec 2015732
Total 20151112930
Jan 20169310
Feb 2016916
Mar 2016110
Apr 2016210
May 2016573
Jun 20166133
Jul 20161046
Aug 2016520
Sep 2016441
Oct 2016873
Nov 2016932
Dec 2016830
Total 2016764934
Jan 20171836
Feb 2017963
Mar 2017340
Apr 2017721
May 2017841
Jun 2017410
Jul 2017320
Aug 2017494
Sep 2017531
Oct 2017311
Nov 2017232
Dec 2017401
Total 2017703820
Jan 2018854
Feb 201810135
Mar 2018665
Apr 201811111
May 201810111
Jun 201811142
Jul 20188100
Aug 20188120
Sep 2018882
Oct 2018191
Nov 20181179
Dec 2018070
Total 20188212330
Jan 2019164
Feb 20190122
Mar 20191163
Apr 20191123
May 2019051
Jun 20190102
Jul 2019062
Aug 20190119
Sep 2019033
Oct 2019132
Nov 2019194
Dec 2019151
Total 201969836
Jan 20201122
Feb 20202103
Mar 20201146
Apr 2020042
May 20200142
Jun 2020185
Jul 2020194
Aug 2020254
Sep 20204113
Oct 20203133
Nov 20202112
Dec 20202174
Total 20201912840
Jan 20210112
Feb 202101510
Mar 20213193
Apr 2021273
Total 202155218
Total119712581051
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And four equals one: Presenilin takes the γ-secretase role by itself
Christian B. Lessard, Steven L. Wagner, Edward H. Koo
Proceedings of the National Academy of Sciences Dec 2010, 107 (50) 21236-21237; DOI: 10.1073/pnas.1016284108

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And four equals one: Presenilin takes the γ-secretase role by itself
Christian B. Lessard, Steven L. Wagner, Edward H. Koo
Proceedings of the National Academy of Sciences Dec 2010, 107 (50) 21236-21237; DOI: 10.1073/pnas.1016284108
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