Table of Contents

Biological Sciences

• Biochemistry

  • You have access

    Rapid DNA–protein cross-linking and strand scission by an abasic site in a nucleosome core particle

    Jonathan T. Sczepanski, Remus S. Wong, Jeffrey N. McKnight, Gregory D. Bowman, and Marc M. Greenberg

    PNAS December 28, 2010 107 (52) 22475-22480; https://doi.org/10.1073/pnas.1012860108
  • You have access

    NMR analysis of the αIIbβ3 cytoplasmic interaction suggests a mechanism for integrin regulation

    Douglas G. Metcalf, David T. Moore, Yibing Wu, Joseph M. Kielec, Kathleen Molnar, Kathleen G. Valentine, A. Joshua Wand, Joel S. Bennett, and William F. DeGrado

    PNAS December 28, 2010 107 (52) 22481-22486; https://doi.org/10.1073/pnas.1015545107
  • Open Access

    Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination

    Gabrielle J. Grundy, Wei Yang, and Martin Gellert

    PNAS December 28, 2010 107 (52) 22487-22492; https://doi.org/10.1073/pnas.1014958107
  • You have access

    Discovery of a minimal form of RNase P in Pyrobaculum

    • From the Cover

    Lien B. Lai, Patricia P. Chan, Aaron E. Cozen, David L. Bernick, James W. Brown, Venkat Gopalan, and Todd M. Lowe

    PNAS December 28, 2010 107 (52) 22493-22498; https://doi.org/10.1073/pnas.1013969107

    See companion article:

    • Discovery of a mini-RNase P in archaea

      - Dec 16, 2010
  • You have access

    Structure of RavA MoxR AAA+ protein reveals the design principles of a molecular cage modulating the inducible lysine decarboxylase activity

    Majida El Bakkouri, Irina Gutsche, Usheer Kanjee, Boyu Zhao, Miao Yu, Gael Goret, Guy Schoehn, Wim P. Burmeister, and Walid A. Houry

    PNAS December 28, 2010 107 (52) 22499-22504; https://doi.org/10.1073/pnas.1009092107
  • You have access

    Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

    Peng Gong and Olve B. Peersen

    PNAS December 28, 2010 107 (52) 22505-22510; https://doi.org/10.1073/pnas.1007626107
  • You have access

    Structural basis of flocculin-mediated social behavior in yeast

    Maik Veelders, Stefan Brückner, Dimitri Ott, Carlo Unverzagt, Hans-Ulrich Mösch, and Lars-Oliver Essen

    PNAS December 28, 2010 107 (52) 22511-22516; https://doi.org/10.1073/pnas.1013210108

• Biophysics and Computational Biology

  • You have access

    Definition of the intermediates and mechanism of the anticancer drug bleomycin using nuclear resonance vibrational spectroscopy and related methods

    Lei V. Liu, Caleb B. Bell III, Shaun D. Wong, Samuel A. Wilson, Yeonju Kwak, Marina S. Chow, Jiyong Zhao, Keith O. Hodgson, Britt Hedman, and Edward I. Solomon

    PNAS December 28, 2010 107 (52) 22419-22424; https://doi.org/10.1073/pnas.1016323107
  • You have access

    Strongly bound citrate stabilizes the apatite nanocrystals in bone

    • From the Cover

    Y.-Y. Hu, A. Rawal, and K. Schmidt-Rohr

    PNAS December 28, 2010 107 (52) 22425-22429; https://doi.org/10.1073/pnas.1009219107

    See companion article:

    • How to control the size and morphology of apatite nanocrystals in bone

      - Dec 17, 2010
  • You have access

    Structural space of protein–protein interfaces is degenerate, close to complete, and highly connected

    Mu Gao and Jeffrey Skolnick

    PNAS December 28, 2010 107 (52) 22517-22522; https://doi.org/10.1073/pnas.1012820107
  • You have access

    Mechanism of tungsten-dependent acetylene hydratase from quantum chemical calculations

    Rong-Zhen Liao, Jian-Guo Yu, and Fahmi Himo

    PNAS December 28, 2010 107 (52) 22523-22527; https://doi.org/10.1073/pnas.1014060108
  • You have access

    Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation

    Mark M. Chen, Alice I. Bartlett, Paul S. Nerenberg, Claire T. Friel, Christian P. R. Hackenberger, Collin M. Stultz, Sheena E. Radford, and Barbara Imperiali

    PNAS December 28, 2010 107 (52) 22528-22533; https://doi.org/10.1073/pnas.1015356107
  • You have access

    Nucleosome-mediated cooperativity between transcription factors

    Leonid A. Mirny

    PNAS December 28, 2010 107 (52) 22534-22539; https://doi.org/10.1073/pnas.0913805107
  • You have access

    Robust circadian clocks from coupled protein-modification and transcription–translation cycles

    David Zwicker, David K. Lubensky, and Pieter Rein ten Wolde

    PNAS December 28, 2010 107 (52) 22540-22545; https://doi.org/10.1073/pnas.1007613107
  • You have access

    Functional dynamics in the voltage-dependent anion channel

    Saskia Villinger, Rodolfo Briones, Karin Giller, Ulrich Zachariae, Adam Lange, Bert L. de Groot, Christian Griesinger, Stefan Becker, and Markus Zweckstetter

    PNAS December 28, 2010 107 (52) 22546-22551; https://doi.org/10.1073/pnas.1012310108

• Cell Biology

  • You have access

    Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE–Sec1/Munc18 membrane fusion complex

    • From the Cover

    Shailendra S. Rathore, Eric G. Bend, Haijia Yu, Marc Hammarlund, Erik M. Jorgensen, and Jingshi Shen

    PNAS December 28, 2010 107 (52) 22399-22406; https://doi.org/10.1073/pnas.1012997108

    See companion article:

    • Testing the SNARE/SM protein model of membrane fusion

      - Dec 17, 2010
  • You have access

    L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability

    Nadia Gurvich, Fabiana Perna, Andrea Farina, Francesca Voza, Silvia Menendez, Jerard Hurwitz, and Stephen D. Nimer

    PNAS December 28, 2010 107 (52) 22552-22557; https://doi.org/10.1073/pnas.1017092108

• Developmental Biology

  • You have access

    microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti

    • Inaugural Article
    • From the Cover

    Bart Bryant, Warren Macdonald, and Alexander S. Raikhel

    PNAS December 28, 2010 107 (52) 22391-22398; https://doi.org/10.1073/pnas.1016230107

    See companion article:

    • Profile of Alexander S. Raikhel

      - Dec 20, 2010
  • You have access

    Spatial restriction of receptor tyrosine kinase activity through a polarized endocytic cycle controls border cell migration

    Gloria Assaker, Damien Ramel, Stefanie K. Wculek, Marcos González-Gaitán, and Gregory Emery

    PNAS December 28, 2010 107 (52) 22558-22563; https://doi.org/10.1073/pnas.1010795108
  • Open Access

    Switching of the core structures of glycosphingolipids from globo- and lacto- to ganglio-series upon human embryonic stem cell differentiation

    Yuh-Jin Liang, Huan-Hsien Kuo, Chi-Hung Lin, Yen-Ying Chen, Bei-Chia Yang, Yuan-Yuan Cheng, Alice L. Yu, Kay-Hooi Khoo, and John Yu

    PNAS December 28, 2010 107 (52) 22564-22569; https://doi.org/10.1073/pnas.1007290108

• Environmental Sciences

  • You have access

    Baseline intrinsic flammability of Earth’s ecosystems estimated from paleoatmospheric oxygen over the past 350 million years

    Claire M. Belcher, Jonathan M. Yearsley, Rory M. Hadden, Jennifer C. McElwain, and Guillermo Rein

    PNAS December 28, 2010 107 (52) 22448-22453; https://doi.org/10.1073/pnas.1011974107

• Evolution

  • You have access

    There’s plenty of time for evolution

    Herbert S. Wilf and Warren J. Ewens

    PNAS December 28, 2010 107 (52) 22454-22456; https://doi.org/10.1073/pnas.1016207107
  • Open Access

    Conservation and canalization of gene expression during angiosperm diversification accompany the origin and evolution of the flower

    André S. Chanderbali, Mi-Jeong Yoo, Laura M. Zahn, Samuel F. Brockington, P. Kerr Wall, Matthew A. Gitzendanner, Victor A. Albert, James Leebens-Mack, Naomi S. Altman, Hong Ma, Claude W. dePamphilis, Douglas E. Soltis, and Pamela S. Soltis

    PNAS December 28, 2010 107 (52) 22570-22575; https://doi.org/10.1073/pnas.1013395108
  • You have access

    Expression patterns of neural genes in Euperipatoides kanangrensis suggest divergent evolution of onychophoran and euarthropod neurogenesis

    Bo Joakim Eriksson and Angelika Stollewerk

    PNAS December 28, 2010 107 (52) 22576-22581; https://doi.org/10.1073/pnas.1008822108

• Genetics

  • You have access

    DNA tandem repeat instability in the Escherichia coli chromosome is stimulated by mismatch repair at an adjacent CAG·CTG trinucleotide repeat

    John K. Blackwood, Ewa A. Okely, Rabaab Zahra, John K. Eykelenboom, and David R. F. Leach

    PNAS December 28, 2010 107 (52) 22582-22586; https://doi.org/10.1073/pnas.1012906108

• Immunology

  • Open Access

    Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues

    Ching-Hung Shen, Oezcan Talay, Vinay S. Mahajan, Ilya B. Leskov, Herman N. Eisen, and Jianzhu Chen

    PNAS December 28, 2010 107 (52) 22587-22592; https://doi.org/10.1073/pnas.1016350108
  • Open Access

    T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism

    Kristina Edfeldt, Philip T. Liu, Rene Chun, Mario Fabri, Mirjam Schenk, Matthew Wheelwright, Caroline Keegan, Stephan R. Krutzik, John S. Adams, Martin Hewison, and Robert L. Modlin

    PNAS December 28, 2010 107 (52) 22593-22598; https://doi.org/10.1073/pnas.1011624108

• Medical Sciences

  • You have access

    Relationship of farm salmon, sea lice, and wild salmon populations

    Gary D. Marty, Sonja M. Saksida, and Terrance J. Quinn II

    PNAS December 28, 2010 107 (52) 22599-22604; https://doi.org/10.1073/pnas.1009573108
  • You have access

    Causal inference methods to study nonrandomized, preexisting development interventions

    Benjamin F. Arnold, Ranjiv S. Khush, Padmavathi Ramaswamy, Alicia G. London, Paramasivan Rajkumar, Prabhakar Ramaprabha, Natesan Durairaj, Alan E. Hubbard, Kalpana Balakrishnan, and John M. Colford Jr.

    PNAS December 28, 2010 107 (52) 22605-22610; https://doi.org/10.1073/pnas.1008944107
  • You have access

    Chemical generation of bispecific antibodies

    Venkata R. Doppalapudi, Jie Huang, Dingguo Liu, Ping Jin, Bin Liu, Lingna Li, Joel Desharnais, Crystal Hagen, Nancy J. Levin, Michael J. Shields, Michelle Parish, Robert E. Murphy, Joselyn Del Rosario, Bryan D. Oates, Jing-Yu Lai, Marla J. Matin, Zemeda Ainekulu, Abhijit Bhat, Curt W. Bradshaw, Gary Woodnutt, Richard A. Lerner, and Rodney W. Lappe

    PNAS December 28, 2010 107 (52) 22611-22616; https://doi.org/10.1073/pnas.1016478108
  • You have access

    IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

    Roberto R. Ricardo-Gonzalez, Alex Red Eagle, Justin I. Odegaard, Hani Jouihan, Christine R. Morel, Jose E. Heredia, Lata Mukundan, Davina Wu, Richard M. Locksley, and Ajay Chawla

    PNAS December 28, 2010 107 (52) 22617-22622; https://doi.org/10.1073/pnas.1009152108
  • You have access

    Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

    Mei Ming, Christopher R. Shea, Xiumei Guo, Xiaoling Li, Keyoumars Soltani, Weinong Han, and Yu-Ying He

    PNAS December 28, 2010 107 (52) 22623-22628; https://doi.org/10.1073/pnas.1010377108
  • You have access

    Follicle-stimulating hormone increases bone mass in female mice

    Charles M. Allan, Robert Kalak, Colin R. Dunstan, Kirsten J. McTavish, Hong Zhou, David J. Handelsman, and Markus J. Seibel

    PNAS December 28, 2010 107 (52) 22629-22634; https://doi.org/10.1073/pnas.1012141108

• Microbiology

  • You have access

    Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody

    Marija Backovic, Rebecca M. DuBois, Joseph J. Cockburn, Andrew J. Sharff, Marie-Christine Vaney, Harald Granzow, Barbara G. Klupp, Gerard Bricogne, Thomas C. Mettenleiter, and Felix A. Rey

    PNAS December 28, 2010 107 (52) 22635-22640; https://doi.org/10.1073/pnas.1011507107
  • You have access

    Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex

    Hisae Matsuura, Austin N. Kirschner, Richard Longnecker, and Theodore S. Jardetzky

    PNAS December 28, 2010 107 (52) 22641-22646; https://doi.org/10.1073/pnas.1011806108
  • You have access

    Attenuation of innate immunity by cytomegalovirus IL-10 establishes a long-term deficit of adaptive antiviral immunity

    W. L. William Chang and Peter A. Barry

    PNAS December 28, 2010 107 (52) 22647-22652; https://doi.org/10.1073/pnas.1013794108
  • You have access

    Transfer of a prion strain to different hosts leads to emergence of strain variants

    Sukhvir P. Mahal, Shawn Browning, Jiali Li, Irena Suponitsky-Kroyter, and Charles Weissmann

    PNAS December 28, 2010 107 (52) 22653-22658; https://doi.org/10.1073/pnas.1013014108

• Neuroscience

  • You have access

    FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels

    Juan M. Garré, Mauricio A. Retamal, Patricia Cassina, Luis Barbeito, Feliksas F. Bukauskas, Juan C. Sáez, Michael V. L. Bennett, and Verónica Abudara

    PNAS December 28, 2010 107 (52) 22659-22664; https://doi.org/10.1073/pnas.1013793107
  • You have access

    Thalamocortical model for a propofol-induced α-rhythm associated with loss of consciousness

    ShiNung Ching, Aylin Cimenser, Patrick L. Purdon, Emery N. Brown, and Nancy J. Kopell

    PNAS December 28, 2010 107 (52) 22665-22670; https://doi.org/10.1073/pnas.1017069108
  • Open Access

    Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival

    Yoshihiro Omori, Taro Chaya, Kimiko Katoh, Naoko Kajimura, Shigeru Sato, Koichiro Muraoka, Shinji Ueno, Toshiyuki Koyasu, Mineo Kondo, and Takahisa Furukawa

    PNAS December 28, 2010 107 (52) 22671-22676; https://doi.org/10.1073/pnas.1009437108
  • You have access

    Differential brain activity states during the perception and nonperception of illusory motion as revealed by magnetoencephalography

    David A. Crowe, Arthur C. Leuthold, and Apostolos P. Georgopoulos

    PNAS December 28, 2010 107 (52) 22677-22681; https://doi.org/10.1073/pnas.1009857108
  • Open Access

    Longitudinal evidence for diminished frontal cortex function in aging

    Lars Nyberg, Alireza Salami, Mikael Andersson, Johan Eriksson, Grégoria Kalpouzos, Karolina Kauppi, Johanna Lind, Sara Pudas, Jonas Persson, and Lars-Göran Nilsson

    PNAS December 28, 2010 107 (52) 22682-22686; https://doi.org/10.1073/pnas.1012651108
  • You have access

    CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease

    Antonella Caccamo, Monica A. Maldonado, Alex F. Bokov, Smita Majumder, and Salvatore Oddo

    PNAS December 28, 2010 107 (52) 22687-22692; https://doi.org/10.1073/pnas.1012851108
  • You have access

    Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons

    Christian Mayer, Maricedes Acosta-Martinez, Sharon L. Dubois, Andrew Wolfe, Sally Radovick, Ulrich Boehm, and Jon E. Levine

    PNAS December 28, 2010 107 (52) 22693-22698; https://doi.org/10.1073/pnas.1012406108
  • You have access

    Differential dynamics and activity-dependent regulation of α- and β-neurexins at developing GABAergic synapses

    Yu Fu and Z. Josh Huang

    PNAS December 28, 2010 107 (52) 22699-22704; https://doi.org/10.1073/pnas.1011233108

• Physiology

  • You have access

    Sleep deprivation impairs precision of waggle dance signaling in honey bees

    Barrett A. Klein, Arno Klein, Margaret K. Wray, Ulrich G. Mueller, and Thomas D. Seeley

    PNAS December 28, 2010 107 (52) 22705-22709; https://doi.org/10.1073/pnas.1009439108
  • Open Access

    KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate

    Jeremiah D. Osteen, Carlos Gonzalez, Kevin J. Sampson, Vivek Iyer, Santiago Rebolledo, H. Peter Larsson, and Robert S. Kass

    PNAS December 28, 2010 107 (52) 22710-22715; https://doi.org/10.1073/pnas.1016300108

• Plant Biology

  • You have access

    Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses

    Shui Wang, Wendy E. Durrant, Junqi Song, Natalie W. Spivey, and Xinnian Dong

    PNAS December 28, 2010 107 (52) 22716-22721; https://doi.org/10.1073/pnas.1005978107
  • You have access

    Hydraulic trade-offs and space filling enable better predictions of vascular structure and function in plants

    V. M. Savage, L. P. Bentley, B. J. Enquist, J. S. Sperry, D. D. Smith, P. B. Reich, and E. I. von Allmen

    PNAS December 28, 2010 107 (52) 22722-22727; https://doi.org/10.1073/pnas.1012194108
  • You have access

    ATP-binding cassette-like transporters are involved in the transport of lignin precursors across plasma and vacuolar membranes

    Yu-Chen Miao and Chang-Jun Liu

    PNAS December 28, 2010 107 (52) 22728-22733; https://doi.org/10.1073/pnas.1007747108
  • You have access

    Spatio-temporal sequence of cross-regulatory events in root meristem growth

    Emanuele Scacchi, Paula Salinas, Bojan Gujas, Luca Santuari, Naden Krogan, Laura Ragni, Thomas Berleth, and Christian S. Hardtke

    PNAS December 28, 2010 107 (52) 22734-22739; https://doi.org/10.1073/pnas.1014716108
  • You have access

    Auxin transport through PIN-FORMED 3 (PIN3) controls shade avoidance and fitness during competition

    Diederik H. Keuskamp, Stephan Pollmann, Laurentius A. C. J. Voesenek, Anton J. M. Peeters, and Ronald Pierik

    PNAS December 28, 2010 107 (52) 22740-22744; https://doi.org/10.1073/pnas.1013457108

• Sustainability Science

  • You have access

    Relationship of farm salmon, sea lice, and wild salmon populations

    Gary D. Marty, Sonja M. Saksida, and Terrance J. Quinn II

    PNAS December 28, 2010 107 (52) 22599-22604; https://doi.org/10.1073/pnas.1009573108

• Systems Biology

  • Open Access

    Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures

    Hideaki Mizuno, Benjamin T. Spike, Geoffrey M. Wahl, and Arnold J. Levine

    PNAS December 28, 2010 107 (52) 22745-22750; https://doi.org/10.1073/pnas.1017001108