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Research Article

Prolonged sensory-selective nerve blockade

Itay Sagie and Daniel S. Kohane
  1. Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children’s Hospital, Harvard Medical School, Boston, MA 02115

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PNAS February 23, 2010 107 (8) 3740-3745; https://doi.org/10.1073/pnas.0911542107
Itay Sagie
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Daniel S. Kohane
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  • For correspondence: daniel.kohane@childrens.harvard.edu
  1. Edited* by Robert Langer, Massachusetts Institute of Technology, Cambridge, MA, and approved January 8, 2010 (received for review October 6, 2009)

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Abstract

Sensory-selective local anesthesia has long been a key goal in local anesthetic development. For example, it allows women to be pain-free during labor without compromising their ability to push. Here we show that prolonged sensory-selective nerve block can be produced by specific concentrations of surfactants—such as are used to enhance drug flux across skin—in combination with QX-314, a lidocaine derivative that has relative difficulty penetrating nerves. For example, injection of 25 mM QX-314 in 30 mM octyltrimethylammonium bromide (OTAB) lasted up to 7 h. Sensory selectivity was imparted to varying degrees by cationic, neutral, and anionic surfactants, and also was achieved with another lidocaine derivative, QX-222. Simultaneous injection of OTAB at a s.c. injection site remote from the sciatic nerve did not result in prolonged sensory-specific nerve blockade from QX-314, suggesting that the observed effect is due to a local interaction between the surfactant and the lidocaine derivative, not a systemic effect.

  • analgesia
  • quaternary lidocaine derivative
  • sensory
  • surfactant
  • local anesthetics

Footnotes

  • 1To whom correspondence should be addressed. E-mail: daniel.kohane{at}childrens.harvard.edu.
  • Author contributions: I.S. and D.S.K. designed research, performed research, analyzed data, and wrote the paper.

  • The authors declare no conflict of interest.

  • ↵*This Direct Submission article had a prearranged editor.

  • This article contains supporting information online at www.pnas.org/cgi/content/full/0911542107/DCSupplemental.

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    Prolonged sensory-selective nerve blockade
    Itay Sagie, Daniel S. Kohane
    Proceedings of the National Academy of Sciences Feb 2010, 107 (8) 3740-3745; DOI: 10.1073/pnas.0911542107

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    Prolonged sensory-selective nerve blockade
    Itay Sagie, Daniel S. Kohane
    Proceedings of the National Academy of Sciences Feb 2010, 107 (8) 3740-3745; DOI: 10.1073/pnas.0911542107
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    Proceedings of the National Academy of Sciences: 107 (8)
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