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Edited by Michael M. Merzenich, University of California, San Francisco, CA, and approved January 24, 2011 (received for review October 19, 2010)
Abstract
Humans are thought to have evolved brain regions in the left frontal and temporal cortex that are uniquely capable of language processing. However, congenitally blind individuals also activate the visual cortex in some verbal tasks. We provide evidence that this visual cortex activity in fact reflects language processing. We find that in congenitally blind individuals, the left visual cortex behaves similarly to classic language regions: (i) BOLD signal is higher during sentence comprehension than during linguistically degraded control conditions that are more difficult; (ii) BOLD signal is modulated by phonological information, lexical semantic information, and sentence-level combinatorial structure; and (iii) functional connectivity with language regions in the left prefrontal cortex and thalamus are increased relative to sighted individuals. We conclude that brain regions that are thought to have evolved for vision can take on language processing as a result of early experience. Innate microcircuit properties are not necessary for a brain region to become involved in language processing.
Footnotes
- 1To whom correspondence should be addressed. E-mail: mbedny{at}mit.edu.
Author contributions: M.B., E.F., and R.S. designed research; M.B. and D.D.-F. performed research; M.B., D.D.-F., and R.S. analyzed data; and M.B., A.P.-L., E.F., and R.S. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1014818108/-/DCSupplemental.
Language processing in the occipital cortex of congenitally blind adults
Article Classifications
- Biological Sciences
- Neuroscience
- Social Sciences
- Psychological and Cognitive Sciences
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