Hunter-gatherer genomic diversity suggests a southern African origin for modern humans

Brenna M. Henn, Christopher R. Gignoux, Matthew Jobin, Julie M. Granka, J. M. Macpherson, Jeffrey M. Kidd, Laura Rodríguez-Botigué, Sohini Ramachandran, Lawrence Hon, Abra Brisbin, Alice A. Lin, Peter A. Underhill, David Comas, Kenneth K. Kidd, Paul J. Norman, Peter Parham, Carlos D. Bustamante, Joanna L. Mountain, and Marcus W. Feldman
PNAS March 29, 2011 108 (13) 5154-5162; https://doi.org/10.1073/pnas.1017511108

  1. Edited by Mary-Claire King, University of Washington, Seattle, WA, and approved February 3, 2011 (received for review November 29, 2010)

Online Impact

 

Article Information

vol. 108 no. 13 5154-5162
DOI: 
https://doi.org/10.1073/pnas.1017511108
PubMed: 
21383195
Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue March 29, 2011.
  • Published first March 7, 2011.
Copyright & Usage: 
Freely available online through the PNAS open access option.

Author Information

  1. Brenna M. Henna,1,
  2. Christopher R. Gignouxb,
  3. Matthew Jobinc,d,
  4. Julie M. Grankae,
  5. J. M. Macphersonf,
  6. Jeffrey M. Kidda,
  7. Laura Rodríguez-Botiguég,
  8. Sohini Ramachandranh,
  9. Lawrence Honf,
  10. Abra Brisbini,
  11. Alice A. Linj,
  12. Peter A. Underhillj,
  13. David Comasg,
  14. Kenneth K. Kiddk,
  15. Paul J. Normanl,
  16. Peter Parhaml,
  17. Carlos D. Bustamantea,
  18. Joanna L. Mountainf, and
  19. Marcus W. Feldmane
  1. aDepartment of Genetics, Stanford University, Stanford, CA 94305;
  2. bUniversity of California, San Francisco, CA 94158;
  3. cDepartment of Anthropology, Santa Clara University, Santa Clara, CA 95050;
  4. dDepartment of Anthropology, Stanford University, Stanford, CA 94305;
  5. eDepartment of Biological Sciences, Stanford University, Stanford CA 94305;
  6. f23andMe, Inc., Mountain View, CA 94043;
  7. gInstitute of Evolutionary Biology, Universitat Pompeu Fabra, 08003 Barcelona, Spain;
  8. hDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912;
  9. iDepartment of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14850;
  10. jDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305;
  11. kDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520; and
  12. lDepartment of Structural Biology, Stanford University, Stanford, CA 94305

  1. Edited by Mary-Claire King, University of Washington, Seattle, WA, and approved February 3, 2011 (received for review November 29, 2010)

Footnotes

  • ↵1To whom correspondence should be addressed. E-mail: bmhenn{at}stanford.edu.

  • Author contributions: B.M.H., P.A.U., C.D.B., and M.W.F. designed research; B.M.H., C.R.G., S.R., and A.A.L. performed research; M.J., L.H., A.B., D.C., K.K.K., P.P., and J.L.M. contributed new reagents/analytic tools; B.M.H., C.R.G., M.J., J.M.G., J.M.M., J.M.K., L.R.-B., and P.J.N. analyzed data; and B.M.H., C.R.G., P.J.N., C.D.B., J.L.M., and M.W.F. wrote the paper.

  • This Feature Article is part of a series identified by the Editorial Board as reporting findings of exceptional significance.

  • Conflict of interest statement: The authors from 23andMe, Inc. (C.R.G., J.M.M., L.H., and J.L.M.) declare competing financial interests as employees at and stock holders of 23andMe, Inc. SNP arrays designed by 23andMe were used to generate a unique dataset reported in this article. To our knowledge, affiliation with 23andMe, Inc. did not bias the results or discussion of results reported in this article.

  • This article is a PNAS Direct Submission.

  • Data deposition: Genotype data will be hosted on a Stanford University website: http://www-evo.stanford.edu/pubs.html.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1017511108/-/DCSupplemental.

Cited By...

Article usage

Article usage: March 2011 to September 2019

AbstractFullPdf
Mar 2011140732774322
Apr 201187887161472
May 20112880305558
Jun 2011948240413
Jul 2011557130279
Aug 2011464123234
Sep 2011516165304
Oct 2011512172276
Nov 2011442146270
Dec 201136792215
Total 20112954723668343
Jan 2012418128241
Feb 2012391151212
Mar 2012428143238
Apr 2012350112174
May 2012375128215
Jun 2012298102156
Jul 2012323144167
Aug 2012349146199
Sep 2012237132147
Oct 2012253124126
Nov 201221385120
Dec 20122047281
Total 2012383914672076
Jan 201320590109
Feb 20131929998
Mar 2013296458121
Apr 201323312790
May 201321988100
Jun 201318910339
Jul 20131827950
Aug 201319410390
Sep 20131637088
Oct 20131989089
Nov 201316910674
Dec 20131658865
Total 2013240515011013
Jan 20141209757
Feb 20141717759
Mar 201418110765
Apr 201431510857
May 201417111570
Jun 201411621350
Jul 20141405756
Aug 20141528244
Sep 201422112157
Oct 201445212157
Nov 20143337277
Dec 20141386839
Total 201425101238688
Jan 20151689648
Feb 20151477150
Mar 20152447455
Apr 20152067459
May 20151526780
Jun 20151716159
Jul 20151515447
Aug 20151725154
Sep 20151787666
Oct 201530891104
Nov 201525692111
Dec 20152446366
Total 20152397870799
Jan 20161887877
Feb 20162367870
Mar 201625510685
Apr 20162139675
May 20161947553
Jun 201617010754
Jul 20161828436
Aug 20162998642
Sep 201624212664
Oct 201619715268
Nov 201618612352
Dec 201615611936
Total 201625181230712
Jan 201713418044
Feb 201717514143
Mar 2017204178108
Apr 201714914548
May 201714520052
Jun 201715865152
Jul 201712747537
Aug 201714529724
Sep 201718038433
Oct 201723034836
Nov 201716934962
Dec 201712345276
Total 201719393800615
Jan 2018151781123
Feb 201823671246
Mar 2018516100580
Apr 201830676085
May 201824947958
Jun 201820342631
Jul 201825353540
Aug 201822848850
Sep 201820931368
Oct 20185725466
Nov 20185128156
Dec 201810338048
Total 201825626414751
Jan 20193659941
Feb 20193133941
Mar 20194925054
Apr 20194534468
May 20194832947
Jun 20193140129
Jul 20195336946
Aug 20193043831
Sep 201992128
Total 20193323281365
Total480492216715362
Back to top
Article Alerts
Email Article
Citation Tools
Request Permissions
Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
Brenna M. Henn, Christopher R. Gignoux, Matthew Jobin, Julie M. Granka, J. M. Macpherson, Jeffrey M. Kidd, Laura Rodríguez-Botigué, Sohini Ramachandran, Lawrence Hon, Abra Brisbin, Alice A. Lin, Peter A. Underhill, David Comas, Kenneth K. Kidd, Paul J. Norman, Peter Parham, Carlos D. Bustamante, Joanna L. Mountain, Marcus W. Feldman
Proceedings of the National Academy of Sciences Mar 2011, 108 (13) 5154-5162; DOI: 10.1073/pnas.1017511108
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Proceedings of the National Academy of Sciences: 116 (37)
Current Issue

Submit

Article Classifications

Jump to section

You May Also be Interested in

Habituation and training of the ravens in the experimental compartments, Haidlhof Research Station, Austria. Image courtesy of Jessie E. C. Adriaense.
Shared emotional states in ravens
Researchers report negative emotional contagion, or the coordination of emotional states between multiple individuals, in common ravens, suggesting convergent emotional evolution in birds and mammals.
Image courtesy of Jessie E. C. Adriaense.
Fishing fleet. Image courtesy of Pixabay/3282700.
Increase in global fishing fleets
A study examines trends in global fishing fleets and finds that by 2015, 68% of the global fishing fleet became motorized, and that the overall number of fleet vessels increased to 3.7 million, despite a consistent decrease in the catch per unit of effort.
Image courtesy of Pixabay/3282700.
Magnified views of fingerprints found on fragments of 11th-century AD jars from the U S Southwest enabled archaeologists to determine the sex of the potter. Image courtesy of John Kantner.
Fingerprints reveal gender roles in ancient society
A method to determine gender from fingerprints suggests pottery making was not a primarily female activity in ancient Puebloan society, challenging previous assumptions about gendered divisions of labor in ancient societies.
Image courtesy of John Kantner.
QnAs with geneticist David Reich
Featured QnAs
QnAs with geneticist David Reich
Image courtesy of Howard Hughes Medical Institute/Bizuayehu Tesfaye.

Similar Articles