Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
- aDepartment of Genetics, Stanford University, Stanford, CA 94305;
- bUniversity of California, San Francisco, CA 94158;
- cDepartment of Anthropology, Santa Clara University, Santa Clara, CA 95050;
- dDepartment of Anthropology, Stanford University, Stanford, CA 94305;
- eDepartment of Biological Sciences, Stanford University, Stanford CA 94305;
- f23andMe, Inc., Mountain View, CA 94043;
- gInstitute of Evolutionary Biology, Universitat Pompeu Fabra, 08003 Barcelona, Spain;
- hDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912;
- iDepartment of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14850;
- jDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305;
- kDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520; and
- lDepartment of Structural Biology, Stanford University, Stanford, CA 94305
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Edited by Mary-Claire King, University of Washington, Seattle, WA, and approved February 3, 2011 (received for review November 29, 2010)

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Article Information
- Published in issue March 29, 2011.
- Published first March 7, 2011.
Author Information
- Brenna M. Henna,1,
- Christopher R. Gignouxb,
- Matthew Jobinc,d,
- Julie M. Grankae,
- J. M. Macphersonf,
- Jeffrey M. Kidda,
- Laura Rodríguez-Botiguég,
- Sohini Ramachandranh,
- Lawrence Honf,
- Abra Brisbini,
- Alice A. Linj,
- Peter A. Underhillj,
- David Comasg,
- Kenneth K. Kiddk,
- Paul J. Normanl,
- Peter Parhaml,
- Carlos D. Bustamantea,
- Joanna L. Mountainf, and
- Marcus W. Feldmane
- aDepartment of Genetics, Stanford University, Stanford, CA 94305;
- bUniversity of California, San Francisco, CA 94158;
- cDepartment of Anthropology, Santa Clara University, Santa Clara, CA 95050;
- dDepartment of Anthropology, Stanford University, Stanford, CA 94305;
- eDepartment of Biological Sciences, Stanford University, Stanford CA 94305;
- f23andMe, Inc., Mountain View, CA 94043;
- gInstitute of Evolutionary Biology, Universitat Pompeu Fabra, 08003 Barcelona, Spain;
- hDepartment of Ecology and Evolutionary Biology, Brown University, Providence, RI 02912;
- iDepartment of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14850;
- jDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305;
- kDepartment of Genetics, Yale University School of Medicine, New Haven, CT 06520; and
- lDepartment of Structural Biology, Stanford University, Stanford, CA 94305
Edited by Mary-Claire King, University of Washington, Seattle, WA, and approved February 3, 2011 (received for review November 29, 2010)
Footnotes
- ↵1To whom correspondence should be addressed. E-mail: bmhenn{at}stanford.edu.
Author contributions: B.M.H., P.A.U., C.D.B., and M.W.F. designed research; B.M.H., C.R.G., S.R., and A.A.L. performed research; M.J., L.H., A.B., D.C., K.K.K., P.P., and J.L.M. contributed new reagents/analytic tools; B.M.H., C.R.G., M.J., J.M.G., J.M.M., J.M.K., L.R.-B., and P.J.N. analyzed data; and B.M.H., C.R.G., P.J.N., C.D.B., J.L.M., and M.W.F. wrote the paper.
This Feature Article is part of a series identified by the Editorial Board as reporting findings of exceptional significance.
Conflict of interest statement: The authors from 23andMe, Inc. (C.R.G., J.M.M., L.H., and J.L.M.) declare competing financial interests as employees at and stock holders of 23andMe, Inc. SNP arrays designed by 23andMe were used to generate a unique dataset reported in this article. To our knowledge, affiliation with 23andMe, Inc. did not bias the results or discussion of results reported in this article.
This article is a PNAS Direct Submission.
Data deposition: Genotype data will be hosted on a Stanford University website: http://www-evo.stanford.edu/pubs.html.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1017511108/-/DCSupplemental.
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