Table of Contents

Biological Sciences

• Anthropology

  • You have access

    Updated chronology for the Miocene hominoid radiation in Western Eurasia

    Isaac Casanovas-Vilar, David M. Alba, Miguel Garcés, Josep M. Robles, and Salvador Moyà-Solà

    PNAS April 5, 2011 108 (14) 5554-5559; https://doi.org/10.1073/pnas.1018562108

• Biochemistry

  • Open Access

    Primordial synthesis of amines and amino acids in a 1958 Miller H₂S-rich spark discharge experiment

    Eric T. Parker, Henderson J. Cleaves, Jason P. Dworkin, Daniel P. Glavin, Michael Callahan, Andrew Aubrey, Antonio Lazcano, and Jeffrey L. Bada

    PNAS April 5, 2011 108 (14) 5526-5531; https://doi.org/10.1073/pnas.1019191108
  • Open Access

    Ectopic B-cell clusters that infiltrate transplanted human kidneys are clonal

    Julong Cheng, Ali Torkamani, Rajesh K. Grover, Teresa M. Jones, Diana I. Ruiz, Nicholas J. Schork, Michael M. Quigley, F. Wesley Hall, Daniel R. Salomon, and Richard A. Lerner

    PNAS April 5, 2011 108 (14) 5560-5565; https://doi.org/10.1073/pnas.1101148108
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    Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins

    • From the Cover

    Dina Finan, M. Amanda Hartman, and James A. Spudich

    PNAS April 5, 2011 108 (14) 5566-5571; https://doi.org/10.1073/pnas.1101415108

    See companion article:

    • Multifunctional myosin VI has a multitude of cargoes

      - Apr 12, 2011
  • Open Access

    Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners

    Gero Strübbe, Christian Popp, Alexander Schmidt, Andrea Pauli, Leonie Ringrose, Christian Beisel, and Renato Paro

    PNAS April 5, 2011 108 (14) 5572-5577; https://doi.org/10.1073/pnas.1007916108
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    Cross-domain inhibition of TACE ectodomain

    Christopher J. Tape, Sofie H. Willems, Sarah L. Dombernowsky, Peter L. Stanley, Marton Fogarasi, Willem Ouwehand, John McCafferty, and Gillian Murphy

    PNAS April 5, 2011 108 (14) 5578-5583; https://doi.org/10.1073/pnas.1017067108
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    Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein

    Fredrik Noborn, Paul O'Callaghan, Erik Hermansson, Xiao Zhang, John B. Ancsin, Ana M. Damas, Ingrid Dacklin, Jenny Presto, Jan Johansson, Maria J. Saraiva, Erik Lundgren, Robert Kisilevsky, Per Westermark, and Jin-Ping Li

    PNAS April 5, 2011 108 (14) 5584-5589; https://doi.org/10.1073/pnas.1101194108
  • Open Access

    E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6

    Richard G. Hibbert, Anding Huang, Rolf Boelens, and Titia K. Sixma

    PNAS April 5, 2011 108 (14) 5590-5595; https://doi.org/10.1073/pnas.1017516108

• Biophysics and Computational Biology

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    Growth, geometry, and mechanics of a blooming lily

    • From the Cover

    Haiyi Liang and L. Mahadevan

    PNAS April 5, 2011 108 (14) 5516-5521; https://doi.org/10.1073/pnas.1007808108
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    Malleability of folding intermediates in the homeodomain superfamily

    Wiktor Banachewicz, Tomasz L. Religa, R. D. Schaeffer, Valerie Daggett, and Alan R. Fersht

    PNAS April 5, 2011 108 (14) 5596-5601; https://doi.org/10.1073/pnas.1101752108
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    Assessing the fractions of tautomeric forms of the imidazole ring of histidine in proteins as a function of pH

    Jorge A. Vila, Yelena A. Arnautova, Yury Vorobjev, and Harold A. Scheraga

    PNAS April 5, 2011 108 (14) 5602-5607; https://doi.org/10.1073/pnas.1102373108
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    Unsuspected pathway of the allosteric transition in hemoglobin

    Stefan Fischer, Kenneth W. Olsen, Kwangho Nam, and Martin Karplus

    PNAS April 5, 2011 108 (14) 5608-5613; https://doi.org/10.1073/pnas.1011995108
  • Open Access

    Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

    Ulrike Haessler, Marco Pisano, Mingming Wu, and Melody A. Swartz

    PNAS April 5, 2011 108 (14) 5614-5619; https://doi.org/10.1073/pnas.1014920108

• Cell Biology

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    Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts

    Nina H. Pipalia, Casey C. Cosner, Amy Huang, Anamitra Chatterjee, Pauline Bourbon, Nathan Farley, Paul Helquist, Olaf Wiest, and Frederick R. Maxfield

    PNAS April 5, 2011 108 (14) 5620-5625; https://doi.org/10.1073/pnas.1014890108
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    Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences

    Yongguang Tao, Sichuan Xi, Jigui Shan, Alika Maunakea, Anney Che, Victorino Briones, Eunice Y. Lee, Theresa Geiman, Jiaqiang Huang, Robert Stephens, Robert M. Leighty, Keji Zhao, and Kathrin Muegge

    PNAS April 5, 2011 108 (14) 5626-5631; https://doi.org/10.1073/pnas.1017000108

• Developmental Biology

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    Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart

    Aibin He, Sek Won Kong, Qing Ma, and William T. Pu

    PNAS April 5, 2011 108 (14) 5632-5637; https://doi.org/10.1073/pnas.1016959108

• Ecology

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    Spatial characterization of the meltwater field from icebergs in the Weddell Sea

    John J. Helly, Ronald S. Kaufmann, Maria Vernet, and Gordon R. Stephenson

    PNAS April 5, 2011 108 (14) 5492-5497; https://doi.org/10.1073/pnas.0909306108
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    A competitive network theory of species diversity

    Stefano Allesina and Jonathan M. Levine

    PNAS April 5, 2011 108 (14) 5638-5642; https://doi.org/10.1073/pnas.1014428108
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    How frequency and intensity shape diversity–disturbance relationships

    Adam D. Miller, Stephen H. Roxburgh, and Katriona Shea

    PNAS April 5, 2011 108 (14) 5643-5648; https://doi.org/10.1073/pnas.1018594108
  • Open Access

    Diatoms respire nitrate to survive dark and anoxic conditions

    Anja Kamp, Dirk de Beer, Jana L. Nitsch, Gaute Lavik, and Peter Stief

    PNAS April 5, 2011 108 (14) 5649-5654; https://doi.org/10.1073/pnas.1015744108

• Environmental Sciences

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    Eastern Equatorial Pacific productivity and related-CO₂ changes since the last glacial period

    Eva Calvo, Carles Pelejero, Leopoldo D. Pena, Isabel Cacho, and Graham A. Logan

    PNAS April 5, 2011 108 (14) 5537-5541; https://doi.org/10.1073/pnas.1009761108
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    Responses to historical climate change identify contemporary threats to diversity in Dodecatheon

    Brad Oberle and Barbara A. Schaal

    PNAS April 5, 2011 108 (14) 5655-5660; https://doi.org/10.1073/pnas.1012302108

• Evolution

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    Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection

    Rebecca Batorsky, Mary F. Kearney, Sarah E. Palmer, Frank Maldarelli, Igor M. Rouzine, and John M. Coffin

    PNAS April 5, 2011 108 (14) 5661-5666; https://doi.org/10.1073/pnas.1102036108
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    Draft genome of the red harvester ant Pogonomyrmex barbatus

    Chris R. Smith, Christopher D. Smith, Hugh M. Robertson, Martin Helmkampf, Aleksey Zimin, Mark Yandell, Carson Holt, Hao Hu, Ehab Abouheif, Richard Benton, Elizabeth Cash, Vincent Croset, Cameron R. Currie, Eran Elhaik, Christine G. Elsik, Marie-Julie Favé, Vilaiwan Fernandes, Joshua D. Gibson, Dan Graur, Wulfila Gronenberg, Kirk J. Grubbs, Darren E. Hagen, Ana Sofia Ibarraran Viniegra, Brian R. Johnson, Reed M. Johnson, Abderrahman Khila, Jay W. Kim, Kaitlyn A. Mathis, Monica C. Munoz-Torres, Marguerite C. Murphy, Julie A. Mustard, Rin Nakamura, Oliver Niehuis, Surabhi Nigam, Rick P. Overson, Jennifer E. Placek, Rajendhran Rajakumar, Justin T. Reese, Garret Suen, Shu Tao, Candice W. Torres, Neil D. Tsutsui, Lumi Viljakainen, Florian Wolschin, and Jürgen Gadau

    PNAS April 5, 2011 108 (14) 5667-5672; https://doi.org/10.1073/pnas.1007901108

    See companion article:

    • The birth of ant genomics

      - Apr 05, 2011
  • Open Access

    Draft genome of the globally widespread and invasive Argentine ant (Linepithema humile)

    Christopher D. Smith, Aleksey Zimin, Carson Holt, Ehab Abouheif, Richard Benton, Elizabeth Cash, Vincent Croset, Cameron R. Currie, Eran Elhaik, Christine G. Elsik, Marie-Julie Fave, Vilaiwan Fernandes, Jürgen Gadau, Joshua D. Gibson, Dan Graur, Kirk J. Grubbs, Darren E. Hagen, Martin Helmkampf, Jo-Anne Holley, Hao Hu, Ana Sofia Ibarraran Viniegra, Brian R. Johnson, Reed M. Johnson, Abderrahman Khila, Jay W. Kim, Joseph Laird, Kaitlyn A. Mathis, Joseph A. Moeller, Monica C. Muñoz-Torres, Marguerite C. Murphy, Rin Nakamura, Surabhi Nigam, Rick P. Overson, Jennifer E. Placek, Rajendhran Rajakumar, Justin T. Reese, Hugh M. Robertson, Chris R. Smith, Andrew V. Suarez, Garret Suen, Elissa L. Suhr, Shu Tao, Candice W. Torres, Ellen van Wilgenburg, Lumi Viljakainen, Kimberly K. O. Walden, Alexander L. Wild, Mark Yandell, James A. Yorke, and Neil D. Tsutsui

    PNAS April 5, 2011 108 (14) 5673-5678; https://doi.org/10.1073/pnas.1008617108

    See companion article:

    • The birth of ant genomics

      - Apr 05, 2011
  • You have access

    The genome of the fire ant Solenopsis invicta

    Yannick Wurm, John Wang, Oksana Riba-Grognuz, Miguel Corona, Sanne Nygaard, Brendan G. Hunt, Krista K. Ingram, Laurent Falquet, Mingkwan Nipitwattanaphon, Dietrich Gotzek, Michiel B. Dijkstra, Jan Oettler, Fabien Comtesse, Cheng-Jen Shih, Wen-Jer Wu, Chin-Cheng Yang, Jerome Thomas, Emmanuel Beaudoing, Sylvain Pradervand, Volker Flegel, Erin D. Cook, Roberto Fabbretti, Heinz Stockinger, Li Long, William G. Farmerie, Jane Oakey, Jacobus J. Boomsma, Pekka Pamilo, Soojin V. Yi, Jürgen Heinze, Michael A. D. Goodisman, Laurent Farinelli, Keith Harshman, Nicolas Hulo, Lorenzo Cerutti, Ioannis Xenarios, DeWayne Shoemaker, and Laurent Keller

    PNAS April 5, 2011 108 (14) 5679-5684; https://doi.org/10.1073/pnas.1009690108

    See companion article:

    • The birth of ant genomics

      - Apr 05, 2011
  • You have access

    Tradeoffs associated with constitutive and induced plant resistance against herbivory

    Anne Kempel, Martin Schädler, Thomas Chrobock, Markus Fischer, and Mark van Kleunen

    PNAS April 5, 2011 108 (14) 5685-5689; https://doi.org/10.1073/pnas.1016508108
  • Open Access

    Episodic radiations in the fly tree of life

    Brian M. Wiegmann, Michelle D. Trautwein, Isaac S. Winkler, Norman B. Barr, Jung-Wook Kim, Christine Lambkin, Matthew A. Bertone, Brian K. Cassel, Keith M. Bayless, Alysha M. Heimberg, Benjamin M. Wheeler, Kevin J. Peterson, Thomas Pape, Bradley J. Sinclair, Jeffrey H. Skevington, Vladimir Blagoderov, Jason Caravas, Sujatha Narayanan Kutty, Urs Schmidt-Ott, Gail E. Kampmeier, F. Christian Thompson, David A. Grimaldi, Andrew T. Beckenbach, Gregory W. Courtney, Markus Friedrich, Rudolf Meier, and David K. Yeates

    PNAS April 5, 2011 108 (14) 5690-5695; https://doi.org/10.1073/pnas.1012675108
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    Stearoyl-acyl carrier protein desaturases are associated with floral isolation in sexually deceptive orchids

    Philipp M. Schlüter, Shuqing Xu, Valeria Gagliardini, Edward Whittle, John Shanklin, Ueli Grossniklaus, and Florian P. Schiestl

    PNAS April 5, 2011 108 (14) 5696-5701; https://doi.org/10.1073/pnas.1013313108
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    Genetic basis of eye and pigment loss in the cave crustacean, Asellus aquaticus

    Meredith E. Protas, Peter Trontelj, and Nipam H. Patel

    PNAS April 5, 2011 108 (14) 5702-5707; https://doi.org/10.1073/pnas.1013850108
  • Open Access

    An evolutionary process that assembles phenotypes through space rather than through time

    Richard Shine, Gregory P. Brown, and Benjamin L. Phillips

    PNAS April 5, 2011 108 (14) 5708-5711; https://doi.org/10.1073/pnas.1018989108

• Genetics

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    Direct regulation of Escherichia coli ribosomal protein promoters by the transcription factors ppGpp and DksA

    Justin J. Lemke, Patricia Sanchez-Vazquez, Hector L. Burgos, Gina Hedberg, Wilma Ross, and Richard L. Gourse

    PNAS April 5, 2011 108 (14) 5712-5717; https://doi.org/10.1073/pnas.1019383108
  • Open Access

    Lysine methyltransferase G9a is required for de novo DNA methylation and the establishment, but not the maintenance, of proviral silencing

    Danny C. Leung, Kevin B. Dong, Irina A. Maksakova, Preeti Goyal, Ruth Appanah, Sandra Lee, Makoto Tachibana, Yoichi Shinkai, Bernhard Lehnertz, Dixie L. Mager, Fabio Rossi, and Matthew C. Lorincz

    PNAS April 5, 2011 108 (14) 5718-5723; https://doi.org/10.1073/pnas.1014660108

• Immunology

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    Single-cell gene-expression profiling reveals qualitatively distinct CD8 T cells elicited by different gene-based vaccines

    Lukas Flatz, Rahul Roychoudhuri, Mitsuo Honda, Abdelali Filali-Mouhim, Jean-Philippe Goulet, Nadia Kettaf, Min Lin, Mario Roederer, Elias K. Haddad, Rafick P. Sékaly, and Gary J. Nabel

    PNAS April 5, 2011 108 (14) 5724-5729; https://doi.org/10.1073/pnas.1013084108
  • Open Access

    Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection

    Kerry A. Millington, Sarah M. Fortune, Jeffrey Low, Alejandra Garces, Suzanne M. Hingley-Wilson, Melissa Wickremasinghe, Onn M. Kon, and Ajit Lalvani

    PNAS April 5, 2011 108 (14) 5730-5735; https://doi.org/10.1073/pnas.1015153108
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    Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection

    Megan M. Dring, Maria H. Morrison, Brian P. McSharry, Kieran J. Guinan, Richard Hagan, Irish HCV Research Consortium, Cliona O'Farrelly, and Clair M. Gardiner

    PNAS April 5, 2011 108 (14) 5736-5741; https://doi.org/10.1073/pnas.1016358108

• Medical Sciences

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    Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

    Masanori Onda, Richard Beers, Laiman Xiang, Byungkook Lee, John E. Weldon, Robert J. Kreitman, and Ira Pastan

    PNAS April 5, 2011 108 (14) 5742-5747; https://doi.org/10.1073/pnas.1102746108
  • Open Access

    Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

    François R. Jornayvaz, Andreas L. Birkenfeld, Michael J. Jurczak, Shoichi Kanda, Blas A. Guigni, Debbie C. Jiang, Dongyan Zhang, Hui-Young Lee, Varman T. Samuel, and Gerald I. Shulman

    PNAS April 5, 2011 108 (14) 5748-5752; https://doi.org/10.1073/pnas.1103451108
  • You have access

    Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance

    Naoki Kobayashi, Kohjiro Ueki, Yukiko Okazaki, Aya Iwane, Naoto Kubota, Mitsuru Ohsugi, Motoharu Awazawa, Masatoshi Kobayashi, Takayoshi Sasako, Kazuma Kaneko, Miho Suzuki, Yoshitaka Nishikawa, Kazuo Hara, Kotaro Yoshimura, Isao Koshima, Susumu Goyama, Koji Murakami, Junko Sasaki, Ryozo Nagai, Mineo Kurokawa, Takehiko Sasaki, and Takashi Kadowaki

    PNAS April 5, 2011 108 (14) 5753-5758; https://doi.org/10.1073/pnas.1016430108
  • You have access

    GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood–brain barrier

    Mike Cullen, Mohammed K. Elzarrad, Steven Seaman, Enrique Zudaire, Janine Stevens, Mi Young Yang, Xiujie Li, Amit Chaudhary, Lihong Xu, Mary Beth Hilton, Daniel Logsdon, Emily Hsiao, Erica V. Stein, Frank Cuttitta, Diana C. Haines, Kunio Nagashima, Lino Tessarollo, and Brad St. Croix

    PNAS April 5, 2011 108 (14) 5759-5764; https://doi.org/10.1073/pnas.1017192108
  • You have access

    A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis

    Timothy K. Starr, Patricia M. Scott, Benjamin M. Marsh, Lei Zhao, Bich L. N. Than, M. Gerard O'Sullivan, Aaron L. Sarver, Adam J. Dupuy, David A. Largaespada, and Robert T. Cormier

    PNAS April 5, 2011 108 (14) 5765-5770; https://doi.org/10.1073/pnas.1018012108

• Microbiology

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    Ordered assembly of murine leukemia virus capsid protein on lipid nanotubes directs specific binding by the restriction factor, Fv1

    Laura Hilditch, Rishi Matadeen, David C. Goldstone, Peter B. Rosenthal, Ian A. Taylor, and Jonathan P. Stoye

    PNAS April 5, 2011 108 (14) 5771-5776; https://doi.org/10.1073/pnas.1100118108
  • You have access

    Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

    Hans-Heinrich Hoffmann, Andrea Kunz, Viviana A. Simon, Peter Palese, and Megan L. Shaw

    PNAS April 5, 2011 108 (14) 5777-5782; https://doi.org/10.1073/pnas.1101143108

• Neuroscience

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    Different nonlinear functions in hippocampus and perirhinal cortex relating functional MRI activity to memory strength

    Zhuang Song, John T. Wixted, Christine N. Smith, and Larry R. Squire

    PNAS April 5, 2011 108 (14) 5783-5788; https://doi.org/10.1073/pnas.1103225108
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    A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

    Malin C. Lagerström, Katarzyna Rogoz, Bjarke Abrahamsen, Anne-Li Lind, Caroline Ölund, Casey Smith, José Alfredo Mendez, Åsa Wallén-Mackenzie, John N. Wood, and Klas Kullander

    PNAS April 5, 2011 108 (14) 5789-5794; https://doi.org/10.1073/pnas.1013602108
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    Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner

    Amy J. Ramsey, Marija Milenkovic, Ana F. Oliveira, Yasmin Escobedo-Lozoya, Saurav Seshadri, Ali Salahpour, Akira Sawa, Ryohei Yasuda, and Marc G. Caron

    PNAS April 5, 2011 108 (14) 5795-5800; https://doi.org/10.1073/pnas.1012621108
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    Time-dependent corticosteroid modulation of prefrontal working memory processing

    Marloes J. A. G. Henckens, Guido A. van Wingen, Marian Joëls, and Guillén Fernández

    PNAS April 5, 2011 108 (14) 5801-5806; https://doi.org/10.1073/pnas.1019128108
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    Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis

    Özlem Karalay, Kathrin Doberauer, Krishna C. Vadodaria, Marlen Knobloch, Lucia Berti, Amaya Miquelajauregui, Manuela Schwark, Ravi Jagasia, Makoto M. Taketo, Victor Tarabykin, D. Chichung Lie, and Sebastian Jessberger

    PNAS April 5, 2011 108 (14) 5807-5812; https://doi.org/10.1073/pnas.1013456108
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    Interaction between hypothalamic dorsomedial nucleus and the suprachiasmatic nucleus determines intensity of food anticipatory behavior

    Guadalupe Acosta-Galvan, Chun-Xia Yi, Jan van der Vliet, Jack H. Jhamandas, Pertti Panula, Manuel Angeles-Castellanos, María del Carmen Basualdo, Carolina Escobar, and Ruud M. Buijs

    PNAS April 5, 2011 108 (14) 5813-5818; https://doi.org/10.1073/pnas.1015551108
  • Open Access

    Soluble amyloid β-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

    Ming Jin, Nina Shepardson, Ting Yang, Gang Chen, Dominic Walsh, and Dennis J. Selkoe

    PNAS April 5, 2011 108 (14) 5819-5824; https://doi.org/10.1073/pnas.1017033108
  • Open Access

    Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia

    Elisa Caberlotto, Vincent Michel, Isabelle Foucher, Amel Bahloul, Richard J. Goodyear, Elise Pepermans, Nicolas Michalski, Isabelle Perfettini, Olinda Alegria-Prévot, Sébastien Chardenoux, Marcio Do Cruzeiro, Jean-Pierre Hardelin, Guy P. Richardson, Paul Avan, Dominique Weil, and Christine Petit

    PNAS April 5, 2011 108 (14) 5825-5830; https://doi.org/10.1073/pnas.1017114108
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    Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

    Bartosz Balana, Innokentiy Maslennikov, Witek Kwiatkowski, Kalyn M. Stern, Laia Bahima, Senyon Choe, and Paul A. Slesinger

    PNAS April 5, 2011 108 (14) 5831-5836; https://doi.org/10.1073/pnas.1018645108
  • Open Access

    Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells

    Ruani N. Fernando, Boris Eleuteri, Shaimaa Abdelhady, Andre Nussenzweig, Michael Andäng, and Patrik Ernfors

    PNAS April 5, 2011 108 (14) 5837-5842; https://doi.org/10.1073/pnas.1014993108
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    Timescale-dependent shaping of correlation by olfactory bulb lateral inhibition

    Sonya Giridhar, Brent Doiron, and Nathaniel N. Urban

    PNAS April 5, 2011 108 (14) 5843-5848; https://doi.org/10.1073/pnas.1015165108
  • Open Access

    AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

    Tyisha Williams, Julien Courchet, Benoit Viollet, Jay E. Brenman, and Franck Polleux

    PNAS April 5, 2011 108 (14) 5849-5854; https://doi.org/10.1073/pnas.1013660108
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    NMDA receptor subunit composition controls synaptogenesis and synapse stabilization

    Abigail C. Gambrill and Andres Barria

    PNAS April 5, 2011 108 (14) 5855-5860; https://doi.org/10.1073/pnas.1012676108
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    Disrupted-in-Schizophrenia 1–mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling

    Shih-Yu Chen, Pei-Hsin Huang, and Hwai-Jong Cheng

    PNAS April 5, 2011 108 (14) 5861-5866; https://doi.org/10.1073/pnas.1018128108

• Pharmacology

  • Open Access

    Agonist activation of α7 nicotinic acetylcholine receptors via an allosteric transmembrane site

    JasKiran K. Gill, Mari Savolainen, Gareth T. Young, Ruud Zwart, Emanuele Sher, and Neil S. Millar

    PNAS April 5, 2011 108 (14) 5867-5872; https://doi.org/10.1073/pnas.1017975108

• Physiology

  • Open Access

    Calmodulin protects against alcohol-induced pancreatic trypsinogen activation elicited via Ca²⁺ release through IP₃ receptors

    Julia V. Gerasimenko, György Lur, Pawel Ferdek, Mark W. Sherwood, Etsuko Ebisui, Alexei V. Tepikin, Katsuhiko Mikoshiba, Ole H. Petersen, and Oleg V. Gerasimenko

    PNAS April 5, 2011 108 (14) 5873-5878; https://doi.org/10.1073/pnas.1016534108
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    Deletion of the Slo3 gene abolishes alkalization-activated K⁺ current in mouse spermatozoa

    Xu-Hui Zeng, Chengtao Yang, Sung Tae Kim, Christopher J. Lingle, and Xiao-Ming Xia

    PNAS April 5, 2011 108 (14) 5879-5884; https://doi.org/10.1073/pnas.1100240108
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    Oxidation of NADPH on Kvβ1 inhibits ball-and-chain type inactivation by restraining the chain

    Yaping Pan, Jun Weng, Elena J. Levin, and Ming Zhou

    PNAS April 5, 2011 108 (14) 5885-5890; https://doi.org/10.1073/pnas.1100316108

• Plant Biology

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    Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

    Petri Lackman, Miguel González-Guzmán, Sofie Tilleman, Inês Carqueijeiro, Amparo Cuéllar Pérez, Tessa Moses, Mitsunori Seo, Yuri Kanno, Suvi T. Häkkinen, Marc C. E. Van Montagu, Johan M. Thevelein, Hannu Maaheimo, Kirsi-Marja Oksman-Caldentey, Pedro L. Rodriguez, Heiko Rischer, and Alain Goossens

    PNAS April 5, 2011 108 (14) 5891-5896; https://doi.org/10.1073/pnas.1103010108
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    Adaptive evolution of threonine deaminase in plant defense against insect herbivores

    Eliana Gonzales-Vigil, Christopher M. Bianchetti, George N. Phillips Jr., and Gregg A. Howe

    PNAS April 5, 2011 108 (14) 5897-5902; https://doi.org/10.1073/pnas.1016157108

• Psychological and Cognitive Sciences

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    Fidelity of neural reactivation reveals competition between memories

    Brice A. Kuhl, Jesse Rissman, Marvin M. Chun, and Anthony D. Wagner

    PNAS April 5, 2011 108 (14) 5903-5908; https://doi.org/10.1073/pnas.1016939108

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