Table of Contents

Biological Sciences

• Agricultural Sciences

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    Genome-wide nested association mapping of quantitative resistance to northern leaf blight in maize

    Jesse A. Poland, Peter J. Bradbury, Edward S. Buckler, and Rebecca J. Nelson

    PNAS April 26, 2011 108 (17) 6893-6898; https://doi.org/10.1073/pnas.1010894108

• Applied Biological Sciences

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    Discovery of new antimalarial chemotypes through chemical methodology and library development

    Lauren E. Brown, Ken Chih-Chien Cheng, Wan-Guo Wei, Pingwei Yuan, Peng Dai, Richard Trilles, Feng Ni, Jing Yuan, Ryan MacArthur, Rajarshi Guha, Ronald L. Johnson, Xin-zhuan Su, Melissa M. Dominguez, John K. Snyder, Aaron B. Beeler, Scott E. Schaus, James Inglese, and John A. Porco Jr.

    PNAS April 26, 2011 108 (17) 6775-6780; https://doi.org/10.1073/pnas.1017666108
  • Open Access

    Fatty acid production in genetically modified cyanobacteria

    Xinyao Liu, Jie Sheng, and Roy Curtiss III

    PNAS April 26, 2011 108 (17) 6899-6904; https://doi.org/10.1073/pnas.1103014108
  • Open Access

    CO₂-limitation-inducible Green Recovery of fatty acids from cyanobacterial biomass

    Xinyao Liu, Sarah Fallon, Jie Sheng, and Roy Curtiss III

    PNAS April 26, 2011 108 (17) 6905-6908; https://doi.org/10.1073/pnas.1103016108
  • Open Access

    Selection of phage-displayed peptides on live adherent cells in microfluidic channels

    Jinpeng Wang, Yanli Liu, Tambet Teesalu, Kazuki N. Sugahara, Venkata Ramana Kotamrajua, Jonathan D. Adams, Brian S. Ferguson, Qiang Gong, Seung Soo Oh, Andrew T. Csordas, Minseon Cho, Erkki Ruoslahti, Yi Xiao, and H. Tom Soh

    PNAS April 26, 2011 108 (17) 6909-6914; https://doi.org/10.1073/pnas.1014753108

• Biochemistry

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    Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

    Daniel A. Bachovchin, Justin T. Mohr, Anna E. Speers, Chu Wang, Jacob M. Berlin, Timothy P. Spicer, Virneliz Fernandez-Vega, Peter Chase, Peter S. Hodder, Stephan C. Schürer, Daniel K. Nomura, Hugh Rosen, Gregory C. Fu, and Benjamin F. Cravatt

    PNAS April 26, 2011 108 (17) 6811-6816; https://doi.org/10.1073/pnas.1015248108
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    Species-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation

    Marika Miot, Michael Reidy, Shannon M. Doyle, Joel R. Hoskins, Danielle M. Johnston, Olivier Genest, Maria-Carmen Vitery, Daniel C. Masison, and Sue Wickner

    PNAS April 26, 2011 108 (17) 6915-6920; https://doi.org/10.1073/pnas.1102828108
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    Solution structure of the Zβ domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs

    Kyungmin Kim, Bulat I. Khayrutdinov, Chung-Kyung Lee, Hae-Kap Cheong, Sung Wook Kang, Hyejin Park, Sangho Lee, Yang-Gyun Kim, JunGoo Jee, Alexander Rich, Kyeong Kyu Kim, and Young Ho Jeon

    PNAS April 26, 2011 108 (17) 6921-6926; https://doi.org/10.1073/pnas.1014898107
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    A sequential mechanism for clathrin cage disassembly by 70-kDa heat-shock cognate protein (Hsc70) and auxilin

    Alice Rothnie, Anthony R. Clarke, Petr Kuzmic, Angus Cameron, and Corinne J. Smith

    PNAS April 26, 2011 108 (17) 6927-6932; https://doi.org/10.1073/pnas.1018845108
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    Misacylation of specific nonmethionyl tRNAs by a bacterial methionyl-tRNA synthetase

    Thomas E. Jones, Rebecca W. Alexander, and Tao Pan

    PNAS April 26, 2011 108 (17) 6933-6938; https://doi.org/10.1073/pnas.1019033108
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    Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I

    Zhongtao Zhang, Bokun Cheng, and Yuk-Ching Tse-Dinh

    PNAS April 26, 2011 108 (17) 6939-6944; https://doi.org/10.1073/pnas.1100300108
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    Biosynthesis of hemiketal eicosanoids by cross-over of the 5-lipoxygenase and cyclooxygenase-2 pathways

    Markus Griesser, Takashi Suzuki, Noemi Tejera, Stacey Mont, William E. Boeglin, Ambra Pozzi, and Claus Schneider

    PNAS April 26, 2011 108 (17) 6945-6950; https://doi.org/10.1073/pnas.1019473108
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    Cisplatin binds human copper chaperone Atox1 and promotes unfolding in vitro

    Maria E. Palm, Christoph F. Weise, Christina Lundin, Gunnar Wingsle, Yvonne Nygren, Erik Björn, Peter Naredi, Magnus Wolf-Watz, and Pernilla Wittung-Stafshede

    PNAS April 26, 2011 108 (17) 6951-6956; https://doi.org/10.1073/pnas.1012899108
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    Mice lacking phosphatase PP2A subunit PR61/B’δ (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3β

    Justin V. Louis, Ellen Martens, Peter Borghgraef, Caroline Lambrecht, Ward Sents, Sari Longin, Karen Zwaenepoel, Robert Pijnenborg, Isabelle Landrieu, Guy Lippens, Birgit Ledermann, Jürgen Götz, Fred Van Leuven, Jozef Goris, and Veerle Janssens

    PNAS April 26, 2011 108 (17) 6957-6962; https://doi.org/10.1073/pnas.1018777108

• Biophysics and Computational Biology

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    Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections

    Paul A. Clemons, J. Anthony Wilson, Vlado Dančík, Sandrine Muller, Hyman A. Carrinski, Bridget K. Wagner, Angela N. Koehler, and Stuart L. Schreiber

    PNAS April 26, 2011 108 (17) 6817-6822; https://doi.org/10.1073/pnas.1015024108
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    Design of a switchable eliminase

    Ivan V. Korendovych, Daniel W. Kulp, Yibing Wu, Hong Cheng, Heinrich Roder, and William F. DeGrado

    PNAS April 26, 2011 108 (17) 6823-6827; https://doi.org/10.1073/pnas.1018191108
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    Probing the invasiveness of prostate cancer cells in a 3D microfabricated landscape

    • From the Cover

    Liyu Liu, Bo Sun, Jonas N. Pedersen, Koh-Meng Aw Yong, Robert H. Getzenberg, Howard A. Stone, and Robert H. Austin

    PNAS April 26, 2011 108 (17) 6853-6856; https://doi.org/10.1073/pnas.1102808108
  • Open Access

    Minimum energy compact structures in force-quench polyubiquitin folding are domain swapped

    Fei Xia, D. Thirumalai, and Frauke Gräter

    PNAS April 26, 2011 108 (17) 6963-6968; https://doi.org/10.1073/pnas.1018177108
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    Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy

    Larry R. Masterson, Lei Shi, Emily Metcalfe, Jiali Gao, Susan S. Taylor, and Gianluigi Veglia

    PNAS April 26, 2011 108 (17) 6969-6974; https://doi.org/10.1073/pnas.1102701108
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    Membrane texture induced by specific protein binding and receptor clustering: active roles for lipids in cellular function

    E. B. Watkins, C. E. Miller, J. Majewski, and T. L. Kuhl

    PNAS April 26, 2011 108 (17) 6975-6980; https://doi.org/10.1073/pnas.1014579108
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    Large-scale characterization of peptide-MHC binding landscapes with structural simulations

    Chen Yanover and Philip Bradley

    PNAS April 26, 2011 108 (17) 6981-6986; https://doi.org/10.1073/pnas.1018165108
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    Allosteric signal transmission in the nucleotide-binding domain of 70-kDa heat shock protein (Hsp70) molecular chaperones

    Anastasia Zhuravleva and Lila M. Gierasch

    PNAS April 26, 2011 108 (17) 6987-6992; https://doi.org/10.1073/pnas.1014448108

• Cell Biology

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    Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

    Sudipta Basu, Bernhard Ellinger, Stefano Rizzo, Céline Deraeve, Markus Schürmann, Hans Preut, Hans-Dieter Arndt, and Herbert Waldmann

    PNAS April 26, 2011 108 (17) 6805-6810; https://doi.org/10.1073/pnas.1015269108
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    Quantification of the forces driving self-assembly of three-dimensional microtissues

    Jacquelyn Youssef, Asha K. Nurse, L. B. Freund, and Jeffrey R. Morgan

    PNAS April 26, 2011 108 (17) 6993-6998; https://doi.org/10.1073/pnas.1102559108
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    Discovery and molecular characterization of a Bcl-2–regulated cell death pathway in schistosomes

    • From the Cover

    Erinna F. Lee, Oliver B. Clarke, Marco Evangelista, Zhiping Feng, Terence P. Speed, Elissaveta B. Tchoubrieva, Andreas Strasser, Bernd H. Kalinna, Peter M. Colman, and W. Douglas Fairlie

    PNAS April 26, 2011 108 (17) 6999-7003; https://doi.org/10.1073/pnas.1100652108
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    Sulfiredoxin–Peroxiredoxin IV axis promotes human lung cancer progression through modulation of specific phosphokinase signaling

    Qiou Wei, Hong Jiang, Zhen Xiao, Alyson Baker, Matthew R. Young, Timothy D. Veenstra, and Nancy H. Colburn

    PNAS April 26, 2011 108 (17) 7004-7009; https://doi.org/10.1073/pnas.1013012108
  • Open Access

    Revealing protein oligomerization and densities in situ using spatial intensity distribution analysis

    Antoine G. Godin, Santiago Costantino, Louis-Etienne Lorenzo, Jody L. Swift, Mikhail Sergeev, Alfredo Ribeiro-da-Silva, Yves De Koninck, and Paul W. Wiseman

    PNAS April 26, 2011 108 (17) 7010-7015; https://doi.org/10.1073/pnas.1018658108
  • Open Access

    Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells

    Jody L. Swift, Antoine G. Godin, Kim Doré, Laure Freland, Nathalie Bouchard, Chelsea Nimmo, Mikhail Sergeev, Yves De Koninck, Paul W. Wiseman, and Jean-Martin Beaulieu

    PNAS April 26, 2011 108 (17) 7016-7021; https://doi.org/10.1073/pnas.1018280108
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    Essential role for Abi1 in embryonic survival and WAVE2 complex integrity

    Patrycja M. Dubielecka, Kathrin I. Ladwein, Xiaoling Xiong, Isabelle Migeotte, Anna Chorzalska, Kathryn V. Anderson, Janet A. Sawicki, Klemens Rottner, Theresia E. Stradal, and Leszek Kotula

    PNAS April 26, 2011 108 (17) 7022-7027; https://doi.org/10.1073/pnas.1016811108
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    Cargo binding activates myosin VIIA motor function in cells

    Tsuyoshi Sakai, Nobuhisa Umeki, Reiko Ikebe, and Mitsuo Ikebe

    PNAS April 26, 2011 108 (17) 7028-7033; https://doi.org/10.1073/pnas.1009188108
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    Cysteine-rich secretory protein 4 is an inhibitor of transient receptor potential M8 with a role in establishing sperm function

    Gerard M. Gibbs, Gerardo Orta, Thulasimala Reddy, Adam J. Koppers, Pablo Martínez-López, José Luis de la Vega-Beltràn, Jennifer C. Y. Lo, Nicholas Veldhuis, Duangporn Jamsai, Peter McIntyre, Alberto Darszon, and Moira K. O'Bryan

    PNAS April 26, 2011 108 (17) 7034-7039; https://doi.org/10.1073/pnas.1015935108
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    Identification and characterization of an oocyte factor required for development of porcine nuclear transfer embryos

    Kei Miyamoto, Kouhei Nagai, Naoya Kitamura, Tomoaki Nishikawa, Haruka Ikegami, Nguyen T. Binh, Satoshi Tsukamoto, Mai Matsumoto, Tomoyuki Tsukiyama, Naojiro Minami, Masayasu Yamada, Hiroyoshi Ariga, Masashi Miyake, Tatsuo Kawarasaki, Kazuya Matsumoto, and Hiroshi Imai

    PNAS April 26, 2011 108 (17) 7040-7045; https://doi.org/10.1073/pnas.1013634108
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    Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak

    José Miguel Eltit, Hongli Li, Christopher W. Ward, Tadeusz Molinski, Isaac N. Pessah, Paul D. Allen, and José R. Lopez

    PNAS April 26, 2011 108 (17) 7046-7051; https://doi.org/10.1073/pnas.1018380108

• Developmental Biology

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    Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases

    John J. Young, Jennifer M. Cherone, Yannick Doyon, Irina Ankoudinova, Farhoud M. Faraji, Andrew H. Lee, Catherine Ngo, Dmitry Y. Guschin, David E. Paschon, Jeffrey C. Miller, Lei Zhang, Edward J. Rebar, Philip D. Gregory, Fyodor D. Urnov, Richard M. Harland, and Bryan Zeitler

    PNAS April 26, 2011 108 (17) 7052-7057; https://doi.org/10.1073/pnas.1102030108
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    Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development

    Yan Geng, Yingying Dong, Mingyan Yu, Long Zhang, Xiaohua Yan, Jingxia Sun, Long Qiao, Huixia Geng, Masahiro Nakajima, Tatsuya Furuichi, Shiro Ikegawa, Xiang Gao, Ye-Guang Chen, Dianhua Jiang, and Wen Ning

    PNAS April 26, 2011 108 (17) 7058-7063; https://doi.org/10.1073/pnas.1007293108
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    Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary

    Susan Eliazer, Nevine A. Shalaby, and Michael Buszczak

    PNAS April 26, 2011 108 (17) 7064-7069; https://doi.org/10.1073/pnas.1015874108

• Ecology

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    Evolutionary history predicts plant defense against an invasive pest

    Gaylord A. Desurmont, Michael J. Donoghue, Wendy L. Clement, and Anurag A. Agrawal

    PNAS April 26, 2011 108 (17) 7070-7074; https://doi.org/10.1073/pnas.1102891108
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    Fluctuations of fish populations and the magnifying effects of fishing

    Andrew O. Shelton and Marc Mangel

    PNAS April 26, 2011 108 (17) 7075-7080; https://doi.org/10.1073/pnas.1100334108

• Environmental Sciences

  • Open Access

    Vaccination strategies for epidemic cholera in Haiti with implications for the developing world

    Dennis L. Chao, M. Elizabeth Halloran, and Ira M. Longini Jr.

    PNAS April 26, 2011 108 (17) 7081-7085; https://doi.org/10.1073/pnas.1102149108
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    Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish

    Corinne E. Hicken, Tiffany L. Linbo, David H. Baldwin, Maryjean L. Willis, Mark S. Myers, Larry Holland, Marie Larsen, Michael S. Stekoll, Stanley D. Rice, Tracy K. Collier, Nathaniel L. Scholz, and John P. Incardona

    PNAS April 26, 2011 108 (17) 7086-7090; https://doi.org/10.1073/pnas.1019031108

• Evolution

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    Multiple mating and its relationship to brood size in pregnant fishes versus pregnant mammals and other viviparous vertebrates

    John C. Avise and Jin-Xian Liu

    PNAS April 26, 2011 108 (17) 7091-7095; https://doi.org/10.1073/pnas.1103329108
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    Polyploidy and ecological adaptation in wild yarrow

    • From the Cover

    Justin Ramsey

    PNAS April 26, 2011 108 (17) 7096-7101; https://doi.org/10.1073/pnas.1016631108
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    Sex pheromone desaturase functioning in a primitive Ostrinia moth is cryptically conserved in congeners’ genomes

    Takeshi Fujii, Katsuhiko Ito, Mitsuko Tatematsu, Toru Shimada, Susumu Katsuma, and Yukio Ishikawa

    PNAS April 26, 2011 108 (17) 7102-7106; https://doi.org/10.1073/pnas.1019519108
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    Comparative analysis of constraints and caste differences in brain investment among social paper wasps

    Sean O'Donnell, Marie Clifford, and Yamile Molina

    PNAS April 26, 2011 108 (17) 7107-7112; https://doi.org/10.1073/pnas.1017566108

• Genetics

  • Open Access

    Reversible suppression of an essential gene in adult mice using transgenic RNA interference

    Katherine McJunkin, Anthony Mazurek, Prem K. Premsrirut, Johannes Zuber, Lukas E. Dow, Janelle Simon, Bruce Stillman, and Scott W. Lowe

    PNAS April 26, 2011 108 (17) 7113-7118; https://doi.org/10.1073/pnas.1104097108
  • Open Access

    Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

    Gunter Schumann, Lachlan J. Coin, Anbarasu Lourdusamy, Pimphen Charoen, Karen H. Berger, David Stacey, Sylvane Desrivières, Fazil A. Aliev, Anokhi A. Khan, Najaf Amin, Yurii S. Aulchenko, Georgy Bakalkin, Stephan J. Bakker, Beverley Balkau, Joline W. Beulens, Ainhoa Bilbao, Rudolf A. de Boer, Delphine Beury, Michiel L. Bots, Elemi J. Breetvelt, Stéphane Cauchi, Christine Cavalcanti-Proença, John C. Chambers, Toni-Kim Clarke, Norbert Dahmen, Eco J. de Geus, Danielle Dick, Francesca Ducci, Alanna Easton, Howard J. Edenberg, Tõnu Esko, Alberto Fernández-Medarde, Tatiana Foroud, Nelson B. Freimer, Jean-Antoine Girault, Diederick E. Grobbee, Simonetta Guarrera, Daniel F. Gudbjartsson, Anna-Liisa Hartikainen, Andrew C. Heath, Victor Hesselbrock, Albert Hofman, Jouke-Jan Hottenga, Matti K. Isohanni, Jaakko Kaprio, Kay-Tee Khaw, Brigitte Kuehnel, Jaana Laitinen, Stéphane Lobbens, Jian'an Luan, Massimo Mangino, Matthieu Maroteaux, Giuseppe Matullo, Mark I. McCarthy, Christian Mueller, Gerjan Navis, Mattijs E. Numans, Alejandro Núñez, Dale R. Nyholt, Charlotte N. Onland-Moret, Ben A. Oostra, Paul F. O'Reilly, Miklos Palkovits, Brenda W. Penninx, Silvia Polidoro, Anneli Pouta, Inga Prokopenko, Fulvio Ricceri, Eugenio Santos, Johannes H. Smit, Nicole Soranzo, Kijoung Song, Ulla Sovio, Michael Stumvoll, Ida Surakk, Thorgeir E. Thorgeirsson, Unnur Thorsteinsdottir, Claire Troakes, Thorarinn Tyrfingsson, Anke Tönjes, Cuno S. Uiterwaal, Andre G. Uitterlinden, Pim van der Harst, Yvonne T. van der Schouw, Oliver Staehlin, Nicole Vogelzangs, Peter Vollenweider, Gerard Waeber, Nicholas J. Wareham, Dawn M. Waterworth, John B. Whitfield, Erich H. Wichmann, Gonneke Willemsen, Jacqueline C. Witteman, Xin Yuan, Guangju Zhai, Jing H. Zhao, Weihua Zhang, Nicholas G. Martin, Andres Metspalu, Angela Doering, James Scott, Tim D. Spector, Ruth J. Loos, Dorret I. Boomsma, Vincent Mooser, Leena Peltonen, Kari Stefansson, Cornelia M. van Duijn, Paolo Vineis, Wolfgang H. Sommer, Jaspal S. Kooner, Rainer Spanagel, Ulrike A. Heberlein, Marjo-Riitta Jarvelin, and Paul Elliott

    PNAS April 26, 2011 108 (17) 7119-7124; https://doi.org/10.1073/pnas.1017288108

• Immunology

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    Design, synthesis, and biological evaluation of a biyouyanagin compound library

    K. C. Nicolaou, Silvano Sanchini, David Sarlah, Gang Lu, T. Robert Wu, Daniel K. Nomura, Benjamin F. Cravatt, Beatrice Cubitt, Juan C. de la Torre, Ann J. Hessell, and Dennis R. Burton

    PNAS April 26, 2011 108 (17) 6715-6720; https://doi.org/10.1073/pnas.1015258108
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    Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity

    Daniel Cruz, Zhiming Wang, Jon Kibbie, Robert Modlin, and Ohyun Kwon

    PNAS April 26, 2011 108 (17) 6769-6774; https://doi.org/10.1073/pnas.1015254108
  • Open Access

    Alternative mechanisms of receptor editing in autoreactive B cells

    Olga Kalinina, Colleen M. Doyle-Cooper, Jennifer Miksanek, Wenzhao Meng, Eline Luning Prak, and Martin G. Weigert

    PNAS April 26, 2011 108 (17) 7125-7130; https://doi.org/10.1073/pnas.1019389108
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    Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

    Barbara J. Flynn, Kathrin Kastenmüller, Ulrike Wille-Reece, Georgia D. Tomaras, Munir Alam, Ross W. Lindsay, Andres M. Salazar, Beatriz Perdiguero, Carmen E. Gomez, Ralf Wagner, Mariano Esteban, Chae G. Park, Christine Trumpfheller, Tibor Keler, Giuseppe Pantaleo, Ralph M. Steinman, and Robert Seder

    PNAS April 26, 2011 108 (17) 7131-7136; https://doi.org/10.1073/pnas.1103869108
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    Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus

    Joerg Ermann, Wendy S. Garrett, Juhi Kuchroo, Khadija Rourida, Jonathan N. Glickman, Andre Bleich, and Laurie H. Glimcher

    PNAS April 26, 2011 108 (17) 7137-7141; https://doi.org/10.1073/pnas.1104234108
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    Anti–ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti–PD-1 or anti-CD137 mAb therapy

    John Stagg, Sherene Loi, Upulie Divisekera, Shin Foong Ngiow, Helene Duret, Hideo Yagita, Michele W. Teng, and Mark J. Smyth

    PNAS April 26, 2011 108 (17) 7142-7147; https://doi.org/10.1073/pnas.1016569108

• Medical Sciences

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    Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

    Amos B. Smith III and Won-Suk Kim

    PNAS April 26, 2011 108 (17) 6787-6792; https://doi.org/10.1073/pnas.1015265108
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    Periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) is a disorder of innate immunity and Th1 activation responsive to IL-1 blockade

    Silvia Stojanov, Sivia Lapidus, Puja Chitkara, Henry Feder, Juan C. Salazar, Thomas A. Fleisher, Margaret R. Brown, Kathryn M. Edwards, Michael M. Ward, Robert A. Colbert, Hong-Wei Sun, Geryl M. Wood, Beverly K. Barham, Anne Jones, Ivona Aksentijevich, Raphaela Goldbach-Mansky, Balu Athreya, Karyl S. Barron, and Daniel L. Kastner

    PNAS April 26, 2011 108 (17) 7148-7153; https://doi.org/10.1073/pnas.1103681108
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    Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice

    Juliana Hamzah, Venkata R. Kotamraju, Jai W. Seo, Lilach Agemy, Valentina Fogal, Lisa M. Mahakian, David Peters, Lise Roth, M. Karen J. Gagnon, Katherine W. Ferrara, and Erkki Ruoslahti

    PNAS April 26, 2011 108 (17) 7154-7159; https://doi.org/10.1073/pnas.1104540108
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    Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

    Roya Navab, Dan Strumpf, Bizhan Bandarchi, Chang-Qi Zhu, Melania Pintilie, Varune Rohan Ramnarine, Emin Ibrahimov, Nikolina Radulovich, Lisa Leung, Malgorzata Barczyk, Devang Panchal, Christine To, James J. Yun, Sandy Der, Frances A. Shepherd, Igor Jurisica, and Ming-Sound Tsao

    PNAS April 26, 2011 108 (17) 7160-7165; https://doi.org/10.1073/pnas.1014506108
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    HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells

    Jonathan E. Feig, James X. Rong, Raanan Shamir, Marie Sanson, Yuliya Vengrenyuk, Jianhua Liu, Katey Rayner, Kathryn Moore, Michael Garabedian, and Edward A. Fisher

    PNAS April 26, 2011 108 (17) 7166-7171; https://doi.org/10.1073/pnas.1016086108
  • Open Access

    Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist

    Claire L. Newton, Adele M. Whay, Craig A. McArdle, Meilin Zhang, Chris J. van Koppen, Ruud van de Lagemaat, Deborah L. Segaloff, and Robert P. Millar

    PNAS April 26, 2011 108 (17) 7172-7176; https://doi.org/10.1073/pnas.1015723108
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    Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells

    Christy C. Ong, Adrian M. Jubb, Peter M. Haverty, Wei Zhou, Victoria Tran, Tom Truong, Helen Turley, Tom O'Brien, Domagoj Vucic, Adrian L. Harris, Marcia Belvin, Lori S. Friedman, Elizabeth M. Blackwood, Hartmut Koeppen, and Klaus P. Hoeflich

    PNAS April 26, 2011 108 (17) 7177-7182; https://doi.org/10.1073/pnas.1103350108

• Microbiology

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    Aryl-homoserine lactone quorum sensing in stem-nodulating photosynthetic bradyrhizobia

    Nathan A. Ahlgren, Caroline S. Harwood, Amy L. Schaefer, Eric Giraud, and E. Peter Greenberg

    PNAS April 26, 2011 108 (17) 7183-7188; https://doi.org/10.1073/pnas.1103821108
  • Open Access

    Generation of targeted Chlamydia trachomatis null mutants

    Laszlo Kari, Morgan M. Goheen, Linnell B. Randall, Lacey D. Taylor, John H. Carlson, William M. Whitmire, Dezso Virok, Krithika Rajaram, Valeria Endresz, Grant McClarty, David E. Nelson, and Harlan D. Caldwell

    PNAS April 26, 2011 108 (17) 7189-7193; https://doi.org/10.1073/pnas.1102229108
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    l-Fucose utilization provides Campylobacter jejuni with a competitive advantage

    Martin Stahl, Lorna M. Friis, Harald Nothaft, Xin Liu, Jianjun Li, Christine M. Szymanski, and Alain Stintzi

    PNAS April 26, 2011 108 (17) 7194-7199; https://doi.org/10.1073/pnas.1014125108
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    Genome sequencing of environmental Escherichia coli expands understanding of the ecology and speciation of the model bacterial species

    Chengwei Luo, Seth T. Walk, David M. Gordon, Michael Feldgarden, James M. Tiedje, and Konstantinos T. Konstantinidis

    PNAS April 26, 2011 108 (17) 7200-7205; https://doi.org/10.1073/pnas.1015622108
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    Genomic RNAs of Borna disease virus are elongated on internal template motifs after realignment of the 3′ termini

    Arnold Martin, Nadja Hoefs, Josefine Tadewaldt, Peter Staeheli, and Urs Schneider

    PNAS April 26, 2011 108 (17) 7206-7211; https://doi.org/10.1073/pnas.1016759108

• Neuroscience

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    Deficit in switching between functional brain networks underlies the impact of multitasking on working memory in older adults

    Wesley C. Clapp, Michael T. Rubens, Jasdeep Sabharwal, and Adam Gazzaley

    PNAS April 26, 2011 108 (17) 7212-7217; https://doi.org/10.1073/pnas.1015297108
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    Serum factors in older individuals change cellular clock properties

    Lucia Pagani, Karen Schmitt, Fides Meier, Jan Izakovic, Konstanze Roemer, Antoine Viola, Christian Cajochen, Anna Wirz-Justice, Steven A. Brown, and Anne Eckert

    PNAS April 26, 2011 108 (17) 7218-7223; https://doi.org/10.1073/pnas.1008882108
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    Tonic inhibition of chronic pain by neuropeptide Y

    Brian Solway, Soma C. Bose, Gregory Corder, Renee R. Donahue, and Bradley K. Taylor

    PNAS April 26, 2011 108 (17) 7224-7229; https://doi.org/10.1073/pnas.1017719108
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    Attracting the attention of a fly

    Preeti Sareen, Reinhard Wolf, and Martin Heisenberg

    PNAS April 26, 2011 108 (17) 7230-7235; https://doi.org/10.1073/pnas.1102522108

• Pharmacology

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    Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators

    Donna M. Huryn, Jeffrey L. Brodsky, Kay M. Brummond, Peter G. Chambers, Benjamin Eyer, Alex W. Ireland, Masaoki Kawasumi, Matthew G. LaPorte, Kayla Lloyd, Baptiste Manteau, Paul Nghiem, Bettina Quade, Sandlin P. Seguin, and Peter Wipf

    PNAS April 26, 2011 108 (17) 6757-6762; https://doi.org/10.1073/pnas.1015251108

• Physiology

  • Open Access

    Motion of myosin head domains during activation and force development in skeletal muscle

    Massimo Reconditi, Elisabetta Brunello, Marco Linari, Pasquale Bianco, Theyencheri Narayanan, Pierre Panine, Gabriella Piazzesi, Vincenzo Lombardi, and Malcolm Irving

    PNAS April 26, 2011 108 (17) 7236-7240; https://doi.org/10.1073/pnas.1018330108

• Plant Biology

  • Open Access

    CIRCADIAN CLOCK-ASSOCIATED 1 and LATE ELONGATED HYPOCOTYL regulate expression of the C-REPEAT BINDING FACTOR (CBF) pathway in Arabidopsis

    Malia A. Dong, Eva M. Farré, and Michael F. Thomashow

    PNAS April 26, 2011 108 (17) 7241-7246; https://doi.org/10.1073/pnas.1103741108
  • Open Access

    Heat induces the splicing by IRE1 of a mRNA encoding a transcription factor involved in the unfolded protein response in Arabidopsis

    Yan Deng, Sabrina Humbert, Jian-Xiang Liu, Renu Srivastava, Steven J. Rothstein, and Stephen H. Howell

    PNAS April 26, 2011 108 (17) 7247-7252; https://doi.org/10.1073/pnas.1102117108
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    Transkingdom signaling based on bacterial cyclodipeptides with auxin activity in plants

    Randy Ortiz-Castro, César Díaz-Pérez, Miguel Martínez-Trujillo, Rosa E. del Río, Jesús Campos-García, and José López-Bucio

    PNAS April 26, 2011 108 (17) 7253-7258; https://doi.org/10.1073/pnas.1006740108

• Population Biology

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    Natural immune boosting in pertussis dynamics and the potential for long-term vaccine failure

    Jennie S. Lavine, Aaron A. King, and Ottar N. Bjørnstad

    PNAS April 26, 2011 108 (17) 7259-7264; https://doi.org/10.1073/pnas.1014394108

• Systems Biology

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    Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity

    Paul A. Wender, Jeremy L. Baryza, Stacey E. Brenner, Brian A. DeChristopher, Brian A. Loy, Adam J. Schrier, and Vishal A. Verma

    PNAS April 26, 2011 108 (17) 6721-6726; https://doi.org/10.1073/pnas.1015270108
  • Open Access

    Topology based data analysis identifies a subgroup of breast cancers with a unique mutational profile and excellent survival

    Monica Nicolau, Arnold J. Levine, and Gunnar Carlsson

    PNAS April 26, 2011 108 (17) 7265-7270; https://doi.org/10.1073/pnas.1102826108
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    A mathematical model for adaptive prediction of environmental changes by microorganisms

    Amir Mitchell and Yitzhak Pilpel

    PNAS April 26, 2011 108 (17) 7271-7276; https://doi.org/10.1073/pnas.1019754108