Table of Contents

Biological Sciences

• Anthropology

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    Genetic evidence for archaic admixture in Africa

    Michael F. Hammer, August E. Woerner, Fernando L. Mendez, Joseph C. Watkins, and Jeffrey D. Wall

    PNAS September 13, 2011 108 (37) 15123-15128; https://doi.org/10.1073/pnas.1109300108
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    Strong reproductive isolation between humans and Neanderthals inferred from observed patterns of introgression

    Mathias Currat and Laurent Excoffier

    PNAS September 13, 2011 108 (37) 15129-15134; https://doi.org/10.1073/pnas.1107450108

• Applied Biological Sciences

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    Reiterative Recombination for the in vivo assembly of libraries of multigene pathways

    Laura M. Wingler and Virginia W. Cornish

    PNAS September 13, 2011 108 (37) 15135-15140; https://doi.org/10.1073/pnas.1100507108

• Biochemistry

  • Open Access

    Chemical genetic strategy for targeting protein kinases based on covalent complementarity

    • Inaugural Article

    Adam L. Garske, Ulf Peters, Arianna T. Cortesi, Jenny L. Perez, and Kevan M. Shokat

    PNAS September 13, 2011 108 (37) 15046-15052; https://doi.org/10.1073/pnas.1111239108

    See companion article:

    • Profile of Kevan M. Shokat

      - Jul 02, 2012
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    Large collective motions regulate the functional properties of glutamate transporter trimers

    Jie Jiang, Indira H. Shrivastava, Spencer D. Watts, Ivet Bahar, and Susan G. Amara

    PNAS September 13, 2011 108 (37) 15141-15146; https://doi.org/10.1073/pnas.1112216108
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    Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding

    Irina Smirnova, Vladimir Kasho, Junichi Sugihara, and H. Ronald Kaback

    PNAS September 13, 2011 108 (37) 15147-15151; https://doi.org/10.1073/pnas.1112157108
  • Open Access

    Snapshots of the maltose transporter during ATP hydrolysis

    Michael L. Oldham and Jue Chen

    PNAS September 13, 2011 108 (37) 15152-15156; https://doi.org/10.1073/pnas.1108858108

    See companion article:

    • Reaction chemistry ABC-style

      - Aug 26, 2011
  • Open Access

    The former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional

    Gráinne McEntee, Stefano Minguzzi, Kirsty O’Brien, Nadia Ben Larbi, Christine Loscher, Ciarán Ó’Fágáin, and Anne Parle-McDermott

    PNAS September 13, 2011 108 (37) 15157-15162; https://doi.org/10.1073/pnas.1103605108
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    Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria

    Donald D. Anderson, Cynthia M. Quintero, and Patrick J. Stover

    PNAS September 13, 2011 108 (37) 15163-15168; https://doi.org/10.1073/pnas.1103623108
  • Open Access

    Insights into Krabbe disease from structures of galactocerebrosidase

    • From the Cover

    Janet E. Deane, Stephen C. Graham, Nee Na Kim, Penelope E. Stein, Rosamund McNair, M. Begoña Cachón-González, Timothy M. Cox, and Randy J. Read

    PNAS September 13, 2011 108 (37) 15169-15173; https://doi.org/10.1073/pnas.1105639108

    See companion article:

    • Sneak peak at galactocerebrosidase, Krabbe disease's lysosomal hydrolase

      - Sep 06, 2011
  • Open Access

    Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding

    Christopher Agnew, Elena Borodina, Nathan R. Zaccai, Rebecca Conners, Nicholas M. Burton, James A. Vicary, David K. Cole, Massimo Antognozzi, Mumtaz Virji, and R. Leo Brady

    PNAS September 13, 2011 108 (37) 15174-15178; https://doi.org/10.1073/pnas.1106341108
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    In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

    Takuya Shiota, Hide Mabuchi, Sachiko Tanaka-Yamano, Koji Yamano, and Toshiya Endo

    PNAS September 13, 2011 108 (37) 15179-15183; https://doi.org/10.1073/pnas.1105921108

• Biophysics and Computational Biology

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    Heterotrimeric G protein β₁γ₂ subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane

    Andrew P. Boughton, Pei Yang, Valerie M. Tesmer, Bei Ding, John J. G. Tesmer, and Zhan Chen

    PNAS September 13, 2011 108 (37) E667-E673; https://doi.org/10.1073/pnas.1108236108
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    Mechanical regulation of vascular growth and tissue regeneration in vivo

    Joel D. Boerckel, Brent A. Uhrig, Nick J. Willett, Nathaniel Huebsch, and Robert E. Guldberg

    PNAS September 13, 2011 108 (37) E674-E680; https://doi.org/10.1073/pnas.1107019108
  • Open Access

    Lack of confidence in approximate Bayesian computation model choice

    Christian P. Robert, Jean-Marie Cornuet, Jean-Michel Marin, and Natesh S. Pillai

    PNAS September 13, 2011 108 (37) 15112-15117; https://doi.org/10.1073/pnas.1102900108
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    On the spontaneous collective motion of active matter

    Shenshen Wang and Peter G. Wolynes

    PNAS September 13, 2011 108 (37) 15184-15189; https://doi.org/10.1073/pnas.1112034108
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    Bayesian design of synthetic biological systems

    Chris P. Barnes, Daniel Silk, Xia Sheng, and Michael P. H. Stumpf

    PNAS September 13, 2011 108 (37) 15190-15195; https://doi.org/10.1073/pnas.1017972108
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    Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

    Natalya V. Dudkina, Mikhail Kudryashev, Henning Stahlberg, and Egbert J. Boekema

    PNAS September 13, 2011 108 (37) 15196-15200; https://doi.org/10.1073/pnas.1107819108

• Cell Biology

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    Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and β-cell apoptosis

    Lukas Adrian Berchtold, Zenia Marian Størling, Fernanda Ortis, Kasper Lage, Claus Bang-Berthelsen, Regine Bergholdt, Jacob Hald, Caroline Anna Brorsson, Decio Laks Eizirik, Flemming Pociot, Søren Brunak, and Joachim Størling

    PNAS September 13, 2011 108 (37) E681-E688; https://doi.org/10.1073/pnas.1104384108
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    Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin

    Nicolas Lecomte, Jon T. Njardarson, Pavel Nagorny, Guangli Yang, Robert Downey, Ouathek Ouerfelli, Malcolm A. S. Moore, and Samuel J. Danishefsky

    PNAS September 13, 2011 108 (37) 15074-15078; https://doi.org/10.1073/pnas.1015247108
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    The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile

    Beatrice T. Wang, Gregory S. Ducker, Andrea J. Barczak, Rebecca Barbeau, David J. Erle, and Kevan M. Shokat

    PNAS September 13, 2011 108 (37) 15201-15206; https://doi.org/10.1073/pnas.1103746108
  • Open Access

    Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells

    Elisa Varela, Ralph P. Schneider, Sagrario Ortega, and Maria A. Blasco

    PNAS September 13, 2011 108 (37) 15207-15212; https://doi.org/10.1073/pnas.1105414108
  • Open Access

    β1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation

    Alexander Meves, Tamar Geiger, Sara Zanivan, John DiGiovanni, Matthias Mann, and Reinhard Fässler

    PNAS September 13, 2011 108 (37) 15213-15218; https://doi.org/10.1073/pnas.1105689108
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    Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice

    Kyu Yeong Choi, Kai Chang, James M. Pickel, John D. Badger II, and Katherine W. Roche

    PNAS September 13, 2011 108 (37) 15219-15224; https://doi.org/10.1073/pnas.1107304108
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    Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis

    Yih-Fung Chen, Wen-Tai Chiu, Ying-Ting Chen, Pey-Yun Lin, Huey-Jy Huang, Cheng-Yang Chou, Hsien-Chang Chang, Ming-Jer Tang, and Meng-Ru Shen

    PNAS September 13, 2011 108 (37) 15225-15230; https://doi.org/10.1073/pnas.1103315108
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    Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation

    Ming Tang, Bo Chen, Tong Lin, Zhaozhong Li, Carolina Pardo, Christine Pampo, Jing Chen, Ching-Ling Lien, Lizi Wu, Lingbao Ai, Heiman Wang, Kai Yao, S. Paul Oh, Edward Seto, Lois E. H. Smith, Dietmar W. Siemann, Michael P. Kladde, Constance L. Cepko, and Jianrong Lu

    PNAS September 13, 2011 108 (37) 15231-15236; https://doi.org/10.1073/pnas.1104662108

• Developmental Biology

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    Placental protection of the fetal brain during short-term food deprivation

    • From the Cover

    Kevin D. Broad and Eric B. Keverne

    PNAS September 13, 2011 108 (37) 15237-15241; https://doi.org/10.1073/pnas.1106022108

    See companion article:

    • Roles of the placenta in fetal brain development

      - Sep 02, 2011
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    Connective tissue growth factor acts within both endothelial cells and β cells to promote proliferation of developing β cells

    Michelle A. Guney, Christine P. Petersen, Andre Boustani, Matthew R. Duncan, Uma Gunasekaran, Renuka Menon, Courtney Warfield, Gary R. Grotendorst, Anna L. Means, Aris N. Economides, and Maureen Gannon

    PNAS September 13, 2011 108 (37) 15242-15247; https://doi.org/10.1073/pnas.1100072108

• Ecology

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    Implications for the hydrologic cycle under climate change due to the expansion of bioenergy crops in the Midwestern United States

    Phong V. V. Le, Praveen Kumar, and Darren T. Drewry

    PNAS September 13, 2011 108 (37) 15085-15090; https://doi.org/10.1073/pnas.1107177108

• Environmental Sciences

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    Extracellular reduction of uranium via Geobacter conductive pili as a protective cellular mechanism

    Dena L. Cologgi, Sanela Lampa-Pastirk, Allison M. Speers, Shelly D. Kelly, and Gemma Reguera

    PNAS September 13, 2011 108 (37) 15248-15252; https://doi.org/10.1073/pnas.1108616108

• Evolution

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    Mass extinction of birds at the Cretaceous–Paleogene (K–Pg) boundary

    Nicholas R. Longrich, Tim Tokaryk, and Daniel J. Field

    PNAS September 13, 2011 108 (37) 15253-15257; https://doi.org/10.1073/pnas.1110395108
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    Horizontal gene transfer facilitated the evolution of plant parasitic mechanisms in the oomycetes

    Thomas A. Richards, Darren M. Soanes, Meredith D. M. Jones, Olga Vasieva, Guy Leonard, Konrad Paszkiewicz, Peter G. Foster, Neil Hall, and Nicholas J. Talbot

    PNAS September 13, 2011 108 (37) 15258-15263; https://doi.org/10.1073/pnas.1105100108
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    Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

    Pawel Burkhardt, Christian M. Stegmann, Benjamin Cooper, Tobias H. Kloepper, Cordelia Imig, Frédérique Varoqueaux, Markus C. Wahl, and Dirk Fasshauer

    PNAS September 13, 2011 108 (37) 15264-15269; https://doi.org/10.1073/pnas.1106189108
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    Convergent evolution of two mammalian neuronal enhancers by sequential exaptation of unrelated retroposons

    Lucía F. Franchini, Rodrigo López-Leal, Sofía Nasif, Paula Beati, Diego M. Gelman, Malcolm J. Low, Flávio J. S. de Souza, and Marcelo Rubinstein

    PNAS September 13, 2011 108 (37) 15270-15275; https://doi.org/10.1073/pnas.1104997108
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    Two types of cis-trans compensation in the evolution of transcriptional regulation

    K. Ryo Takahasi, Takashi Matsuo, and Toshiyuki Takano-Shimizu-Kouno

    PNAS September 13, 2011 108 (37) 15276-15281; https://doi.org/10.1073/pnas.1105814108
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    Alternative splicing of a single transcription factor drives selfish reproductive behavior in honeybee workers (Apis mellifera)

    Antje Jarosch, Eckart Stolle, Robin M. Crewe, and Robin F. A. Moritz

    PNAS September 13, 2011 108 (37) 15282-15287; https://doi.org/10.1073/pnas.1109343108

• Genetics

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    Asymmetric dispersal allows an upstream region to control population structure throughout a species’ range

    James M. Pringle, April M. H. Blakeslee, James E. Byers, and Joe Roman

    PNAS September 13, 2011 108 (37) 15288-15293; https://doi.org/10.1073/pnas.1100473108
  • Open Access

    Context-dependent individualization of nucleotides and virtual genomic hybridization allow the precise location of human SNPs

    José Reyes, Laura Gómez-Romero, Ximena Ibarra-Soria, Kim Palacios-Flores, Luis R. Arriola, Alejandro Wences, Delfino García, Margareta Boege, Guillermo Dávila, Margarita Flores, and Rafael Palacios

    PNAS September 13, 2011 108 (37) 15294-15299; https://doi.org/10.1073/pnas.1112567108
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    Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1

    María Moriel-Carretero, Cristina Tous, and Andrés Aguilera

    PNAS September 13, 2011 108 (37) 15300-15305; https://doi.org/10.1073/pnas.1107425108

• Immunology

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    Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8⁺ T cells

    Alice E. Denton, Brendan E. Russ, Peter C. Doherty, Sudha Rao, and Stephen J. Turner

    PNAS September 13, 2011 108 (37) 15306-15311; https://doi.org/10.1073/pnas.1112520108
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    Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity

    Jennifer V. Lu, Brian M. Weist, Bram J. van Raam, Brett S. Marro, Long V. Nguyen, Prathna Srinivas, Bryan D. Bell, Keith A. Luhrs, Thomas E. Lane, Guy S. Salvesen, and Craig M. Walsh

    PNAS September 13, 2011 108 (37) 15312-15317; https://doi.org/10.1073/pnas.1102779108
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    Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes

    Daniel E. Speiser, Sébastien Wieckowski, Bhawna Gupta, Emanuela M. Iancu, Petra Baumgaertner, Lukas Baitsch, Olivier Michielin, Pedro Romero, and Nathalie Rufer

    PNAS September 13, 2011 108 (37) 15318-15323; https://doi.org/10.1073/pnas.1105419108
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    Inflammasome is a central player in the induction of obesity and insulin resistance

    Rinke Stienstra, Janna A. van Diepen, Cees J. Tack, Md. Hasan Zaki, Frank L. van de Veerdonk, Deshani Perera, Geoffrey A. Neale, Guido J. Hooiveld, Anneke Hijmans, Irene Vroegrijk, Sjoerd van den Berg, Johannes Romijn, Patrick C. N. Rensen, Leo A. B. Joosten, Mihai G. Netea, and Thirumala-Devi Kanneganti

    PNAS September 13, 2011 108 (37) 15324-15329; https://doi.org/10.1073/pnas.1100255108

• Medical Sciences

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    CD4⁺ T cells from elite suppressors are more susceptible to HIV-1 but produce fewer virions than cells from chronic progressors

    Karen A. O'Connell, S. Alireza Rabi, Robert F. Siliciano, and Joel N. Blankson

    PNAS September 13, 2011 108 (37) E689-E698; https://doi.org/10.1073/pnas.1108866108
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    PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis

    Nina Ilic, Tamara Utermark, Hans R. Widlund, and Thomas M. Roberts

    PNAS September 13, 2011 108 (37) E699-E708; https://doi.org/10.1073/pnas.1108237108
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    Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice

    Xuefen Xie, Michael S. Brown, John M. Shelton, James A. Richardson, Joseph L. Goldstein, and Guosheng Liang

    PNAS September 13, 2011 108 (37) 15330-15335; https://doi.org/10.1073/pnas.1112751108
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    Exosomal evasion of humoral immunotherapy in aggressive B-cell lymphoma modulated by ATP-binding cassette transporter A3

    Thiha Aung, Bjoern Chapuy, Daniel Vogel, Dirk Wenzel, Martin Oppermann, Marlen Lahmann, Toni Weinhage, Kerstin Menck, Timo Hupfeld, Raphael Koch, Lorenz Trümper, and Gerald G. Wulf

    PNAS September 13, 2011 108 (37) 15336-15341; https://doi.org/10.1073/pnas.1102855108
  • Open Access

    Fluid forces control endothelial sprouting

    Jonathan W. Song and Lance L. Munn

    PNAS September 13, 2011 108 (37) 15342-15347; https://doi.org/10.1073/pnas.1105316108
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    Forced expression of laminin β1 in podocytes prevents nephrotic syndrome in mice lacking laminin β2, a model for Pierson syndrome

    Jung Hee Suh, George Jarad, Rene G. VanDeVoorde, and Jeffrey H. Miner

    PNAS September 13, 2011 108 (37) 15348-15353; https://doi.org/10.1073/pnas.1108269108
  • Open Access

    Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis

    Andrew C. Goodwin, Christina E. Destefano Shields, Shaoguang Wu, David L. Huso, XinQun Wu, Tracy R. Murray-Stewart, Amy Hacker-Prietz, Shervin Rabizadeh, Patrick M. Woster, Cynthia L. Sears, and Robert A. Casero Jr.

    PNAS September 13, 2011 108 (37) 15354-15359; https://doi.org/10.1073/pnas.1010203108

• Microbiology

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    Global discovery of small RNAs in Yersinia pseudotuberculosis identifies Yersinia-specific small, noncoding RNAs required for virulence

    Jovanka T. Koo, Trevis M. Alleyne, Chelsea A. Schiano, Nadereh Jafari, and Wyndham W. Lathem

    PNAS September 13, 2011 108 (37) E709-E717; https://doi.org/10.1073/pnas.1101655108
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    Quantitative lipid composition of cell envelopes of Corynebacterium glutamicum elucidated through reverse micelle extraction

    Ritu Bansal-Mutalik and Hiroshi Nikaido

    PNAS September 13, 2011 108 (37) 15360-15365; https://doi.org/10.1073/pnas.1112572108
  • Open Access

    Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

    Samuel W. Gerritz, Christopher Cianci, Sean Kim, Bradley C. Pearce, Carol Deminie, Linda Discotto, Brian McAuliffe, Beatrice F. Minassian, Shuhao Shi, Shirong Zhu, Weixu Zhai, Annapurna Pendri, Guo Li, Michael A. Poss, Suzanne Edavettal, Patricia A. McDonnell, Hal A. Lewis, Klaus Maskos, Mario Mörtl, Reiner Kiefersauer, Stefan Steinbacher, Eric T. Baldwin, William Metzler, James Bryson, Matthew D. Healy, Thomas Philip, Mary Zoeckler, Richard Schartman, Michael Sinz, Victor H. Leyva-Grado, Hans-Heinrich Hoffmann, David R. Langley, Nicholas A. Meanwell, and Mark Krystal

    PNAS September 13, 2011 108 (37) 15366-15371; https://doi.org/10.1073/pnas.1107906108
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    Intramolecular signal transmission in a tetrameric repressor of the IclR family

    Sandy Fillet, Tino Krell, Bertrand Morel, Duo Lu, Xiaodong Zhang, and Juan L. Ramos

    PNAS September 13, 2011 108 (37) 15372-15377; https://doi.org/10.1073/pnas.1018894108
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    Metabolic basis for the differential susceptibility of Gram-positive pathogens to fatty acid synthesis inhibitors

    Joshua B. Parsons, Matthew W. Frank, Chitra Subramanian, Panatda Saenkham, and Charles O. Rock

    PNAS September 13, 2011 108 (37) 15378-15383; https://doi.org/10.1073/pnas.1109208108
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    Expression of the Sendai (murine parainfluenza) virus C protein alleviates restriction of measles virus growth in mouse cells

    Masaharu Iwasaki and Yusuke Yanagi

    PNAS September 13, 2011 108 (37) 15384-15389; https://doi.org/10.1073/pnas.1107382108

    See companion article:

    • Virus-driven conditional expression of an interferon antagonist as a tool to circumvent host restriction

      - Oct 10, 2011
  • You have access

    Bacterial outer membrane channel for divalent metal ion acquisition

    Thomas H. Hohle, William L. Franck, Gary Stacey, and Mark R. O'Brian

    PNAS September 13, 2011 108 (37) 15390-15395; https://doi.org/10.1073/pnas.1110137108
  • Open Access

    Circadian transcriptional regulation by the posttranslational oscillator without de novo clock gene expression in Synechococcus

    Norimune Hosokawa, Tetsuhiro S. Hatakeyama, Takashi Kojima, Yoshiyuki Kikuchi, Hiroshi Ito, and Hideo Iwasaki

    PNAS September 13, 2011 108 (37) 15396-15401; https://doi.org/10.1073/pnas.1019612108

• Neuroscience

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    Large-scale navigational map in a mammal

    • From the Cover

    Asaf Tsoar, Ran Nathan, Yoav Bartan, Alexei Vyssotski, Giacomo Dell'Omo, and Nachum Ulanovsky

    PNAS September 13, 2011 108 (37) E718-E724; https://doi.org/10.1073/pnas.1107365108

    See companion article:

    • A bat's perspective on navigation

      - Sep 08, 2011
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    Optical imaging in galagos reveals parietal–frontal circuits underlying motor behavior

    Iwona Stepniewska, Robert M. Friedman, Omar A. Gharbawie, Christina M. Cerkevich, Anna W. Roe, and Jon H. Kaas

    PNAS September 13, 2011 108 (37) E725-E732; https://doi.org/10.1073/pnas.1109925108
  • Open Access

    Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation

    Vladislav Volman, Maxim Bazhenov, and Terrence J. Sejnowski

    PNAS September 13, 2011 108 (37) 15402-15407; https://doi.org/10.1073/pnas.1112066108
  • Open Access

    Cross-modal responses in the primary visual cortex encode complex objects and correlate with tactile discrimination

    Nivaldo Vasconcelos, Janaina Pantoja, Hindiael Belchior, Fábio Viegas Caixeta, Jean Faber, Marco Aurelio M. Freire, Vinícius Rosa Cota, Edson Anibal de Macedo, Diego A. Laplagne, Herman Martins Gomes, and Sidarta Ribeiro

    PNAS September 13, 2011 108 (37) 15408-15413; https://doi.org/10.1073/pnas.1102780108
  • Open Access

    Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors

    • From the Cover

    Kevin T. Beier, Arpiar Saunders, Ian A. Oldenburg, Kazunari Miyamichi, Nazia Akhtar, Liqun Luo, Sean P. J. Whelan, Bernardo Sabatini, and Constance L. Cepko

    PNAS September 13, 2011 108 (37) 15414-15419; https://doi.org/10.1073/pnas.1110854108

    See companion article:

    • Neural circuits look forward

      - Sep 13, 2011
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    Dendritic coding of multiple sensory inputs in single cortical neurons in vivo

    Zsuzsanna Varga, Hongbo Jia, Bert Sakmann, and Arthur Konnerth

    PNAS September 13, 2011 108 (37) 15420-15425; https://doi.org/10.1073/pnas.1112355108
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    Mapping the receptor site for α-scorpion toxins on a Na⁺ channel voltage sensor

    Jinti Wang, Vladimir Yarov-Yarovoy, Roy Kahn, Dalia Gordon, Michael Gurevitz, Todd Scheuer, and William A. Catterall

    PNAS September 13, 2011 108 (37) 15426-15431; https://doi.org/10.1073/pnas.1112320108
  • Open Access

    Mouse model of Timothy syndrome recapitulates triad of autistic traits

    Patrick L. Bader, Mehrdad Faizi, Leo H. Kim, Scott F. Owen, Michael R. Tadross, Ronald W. Alfa, Glenna C. L. Bett, Richard W. Tsien, Randall L. Rasmusson, and Mehrdad Shamloo

    PNAS September 13, 2011 108 (37) 15432-15437; https://doi.org/10.1073/pnas.1112667108
  • Open Access

    Interplay between spontaneous and induced brain activity during human non-rapid eye movement sleep

    Thien Thanh Dang-Vu, Maxime Bonjean, Manuel Schabus, Mélanie Boly, Annabelle Darsaud, Martin Desseilles, Christian Degueldre, Evelyne Balteau, Christophe Phillips, André Luxen, Terrence J. Sejnowski, and Pierre Maquet

    PNAS September 13, 2011 108 (37) 15438-15443; https://doi.org/10.1073/pnas.1112503108
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    Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA₁) signaling

    Keira Joann Herr, Deron R. Herr, Chang-Wook Lee, Kyoko Noguchi, and Jerold Chun

    PNAS September 13, 2011 108 (37) 15444-15449; https://doi.org/10.1073/pnas.1106129108
  • Open Access

    Global impairment and therapeutic restoration of visual plasticity mechanisms after a localized cortical stroke

    Franziska Greifzu, Silvio Schmidt, Karl-Friedrich Schmidt, Klaus Kreikemeier, Otto W. Witte, and Siegrid Löwel

    PNAS September 13, 2011 108 (37) 15450-15455; https://doi.org/10.1073/pnas.1016458108
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    Mitochondrial matrix Ca²⁺ as an intrinsic signal regulating mitochondrial motility in axons

    Karen T. Chang, Robert F. Niescier, and Kyung-Tai Min

    PNAS September 13, 2011 108 (37) 15456-15461; https://doi.org/10.1073/pnas.1106862108
  • Open Access

    Dopamine neurons learn to encode the long-term value of multiple future rewards

    Kazuki Enomoto, Naoyuki Matsumoto, Sadamu Nakai, Takemasa Satoh, Tatsuo K. Sato, Yasumasa Ueda, Hitoshi Inokawa, Masahiko Haruno, and Minoru Kimura

    PNAS September 13, 2011 108 (37) 15462-15467; https://doi.org/10.1073/pnas.1014457108
  • Open Access

    Chemical modulation of memory formation in larval zebrafish

    Marc A. Wolman, Roshan A. Jain, Laura Liss, and Michael Granato

    PNAS September 13, 2011 108 (37) 15468-15473; https://doi.org/10.1073/pnas.1107156108
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    The neuronal K-Cl cotransporter KCC2 influences postsynaptic AMPA receptor content and lateral diffusion in dendritic spines

    Grégory Gauvain, Ingrid Chamma, Quentin Chevy, Carolina Cabezas, Theano Irinopoulou, Natalia Bodrug, Michèle Carnaud, Sabine Lévi, and Jean Christophe Poncer

    PNAS September 13, 2011 108 (37) 15474-15479; https://doi.org/10.1073/pnas.1107893108

• Pharmacology

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    Interdomain movements in metabotropic glutamate receptor activation

    Siluo Huang, Jianhua Cao, Ming Jiang, Gilles Labesse, Jianfeng Liu, Jean-Philippe Pin, and Philippe Rondard

    PNAS September 13, 2011 108 (37) 15480-15485; https://doi.org/10.1073/pnas.1107775108

• Physiology

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    Mechanistic basis of bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium

    Tadashi Shinohara, Takayuki Michikawa, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, and Katsuhiko Mikoshiba

    PNAS September 13, 2011 108 (37) 15486-15491; https://doi.org/10.1073/pnas.1101677108

• Plant Biology

  • Open Access

    A special pair of phytohormones controls excitability, slow closure, and external stomach formation in the Venus flytrap

    María Escalante-Pérez, Elzbieta Krol, Annette Stange, Dietmar Geiger, Khaled A. S. Al-Rasheid, Bettina Hause, Erwin Neher, and Rainer Hedrich

    PNAS September 13, 2011 108 (37) 15492-15497; https://doi.org/10.1073/pnas.1112535108
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    A 5-methylcytosine DNA glycosylase/lyase demethylates the retrotransposon Tos17 and promotes its transposition in rice

    Honggui La, Bo Ding, Gyan P. Mishra, Bo Zhou, Hongmei Yang, Maria del Rosario Bellizzi, Songbiao Chen, Blake C. Meyers, Zhaohua Peng, Jian-Kang Zhu, and Guo-Liang Wang

    PNAS September 13, 2011 108 (37) 15498-15503; https://doi.org/10.1073/pnas.1112704108

• Population Biology

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    Role of stochastic processes in maintaining discrete strain structure in antigenically diverse pathogen populations

    Caroline O. Buckee, Mario Recker, Eleanor R. Watkins, and Sunetra Gupta

    PNAS September 13, 2011 108 (37) 15504-15509; https://doi.org/10.1073/pnas.1102445108

• Psychological and Cognitive Sciences

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    Recovery of stereopsis through perceptual learning in human adults with abnormal binocular vision

    Jian Ding and Dennis M. Levi

    PNAS September 13, 2011 108 (37) E733-E741; https://doi.org/10.1073/pnas.1105183108
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    The motor origins of human and avian song structure

    Adam T. Tierney, Frank A. Russo, and Aniruddh D. Patel

    PNAS September 13, 2011 108 (37) 15510-15515; https://doi.org/10.1073/pnas.1103882108
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    Normal hearing is not enough to guarantee robust encoding of suprathreshold features important in everyday communication

    Dorea Ruggles, Hari Bharadwaj, and Barbara G. Shinn-Cunningham

    PNAS September 13, 2011 108 (37) 15516-15521; https://doi.org/10.1073/pnas.1108912108

    See companion article:

    • Hearing impairments hidden in normal listeners

      - Sep 16, 2011

• Systems Biology

  • Open Access

    Functional characterization of bacterial sRNAs using a network biology approach

    Sheetal R. Modi, Diogo M. Camacho, Michael A. Kohanski, Graham C. Walker, and James J. Collins

    PNAS September 13, 2011 108 (37) 15522-15527; https://doi.org/10.1073/pnas.1104318108
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    Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

    Kevin G. Roelofs, Jingxin Wang, Herman O. Sintim, and Vincent T. Lee

    PNAS September 13, 2011 108 (37) 15528-15533; https://doi.org/10.1073/pnas.1018949108