Research Article

Structural flexibility of the Gαs α-helical domain in the β2-adrenoceptor Gs complex

Gerwin H. Westfield, Søren G. F. Rasmussen, Min Su, Somnath Dutta, Brian T. DeVree, Ka Young Chung, Diane Calinski, Gisselle Velez-Ruiz, Austin N. Oleskie, Els Pardon, Pil Seok Chae, Tong Liu, Sheng Li, Virgil L. Woods Jr., Jan Steyaert, Brian K. Kobilka, Roger K. Sunahara, and Georgios Skiniotis
PNAS September 20, 2011 108 (38) 16086-16091; https://doi.org/10.1073/pnas.1113645108

  1. Contributed by Brian K. Kobilka, August 19, 2011 (sent for review August 9, 2011)

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Article Information

vol. 108 no. 38 16086-16091
DOI: 
https://doi.org/10.1073/pnas.1113645108
PubMed: 
21914848
Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue September 20, 2011.
  • Published first September 13, 2011.

Author Information

  1. Gerwin H. Westfielda,1,
  2. Søren G. F. Rasmussenb,c,1,
  3. Min Sua,1,
  4. Somnath Duttaa,1,
  5. Brian T. DeVreed,
  6. Ka Young Chungb,
  7. Diane Calinskid,
  8. Gisselle Velez-Ruizd,
  9. Austin N. Oleskiea,
  10. Els Pardone,f,
  11. Pil Seok Chaeg,
  12. Tong Liuh,
  13. Sheng Lih,
  14. Virgil L. Woods, Jr.h,
  15. Jan Steyaerte,f,
  16. Brian K. Kobilkab,2,
  17. Roger K. Sunaharad,2, and
  18. Georgios Skiniotisa,2
  1. aLife Sciences Institute and Department of Biological Chemistry,
  2. dDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109;
  3. bDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;
  4. cDepartment of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, 2200 Copenhagen N, Denmark;
  5. eStructural Biology Brussels and
  6. fVIB Department of Structural Biology, Vrije Universiteit Brussels, 1050 Brussels, Belgium;
  7. gDepartment of Chemistry, University of Wisconsin, Madison, WI 53706; and
  8. hDepartment of Chemistry, University of California at San Diego, La Jolla, CA 92093

  1. Contributed by Brian K. Kobilka, August 19, 2011 (sent for review August 9, 2011)

Footnotes

  • ↵1G.H.W., S.G.F.R., M.S., and S.D. contributed equally to this work.

  • 2To whom correspondence may be addressed. E-mail: kobilka{at}stanford.edu, sunahara{at}umich.edu, or skinioti{at}umich.edu.

  • Author contributions: V.L.W., J.S., B.K.K., R.K.S., and G.S. designed research; G.H.W., S.G.F.R., M.S., S.D., B.T.D., K.Y.C., D.C., G.V.-R., A.N.O., E.P., P.S.C., T.L., S.L., and G.S. performed research; and B.K.K., R.K.S., and G.S. wrote the paper.

  • The authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1113645108/-/DCSupplemental.

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Sep 202005117
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Total 202099638220
Jan 202145629
Total 202145629
Total834553924158
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Structural flexibility of the Gαs α-helical domain in the β2-adrenoceptor Gs complex
Gerwin H. Westfield, Søren G. F. Rasmussen, Min Su, Somnath Dutta, Brian T. DeVree, Ka Young Chung, Diane Calinski, Gisselle Velez-Ruiz, Austin N. Oleskie, Els Pardon, Pil Seok Chae, Tong Liu, Sheng Li, Virgil L. Woods, Jan Steyaert, Brian K. Kobilka, Roger K. Sunahara, Georgios Skiniotis
Proceedings of the National Academy of Sciences Sep 2011, 108 (38) 16086-16091; DOI: 10.1073/pnas.1113645108
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