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Biological Sciences

• Applied Biological Sciences

  • Open Access

    Requirements for effective malaria control with homing endonuclease genes

    Anne Deredec, H. Charles J. Godfray, and Austin Burt

    PNAS October 25, 2011 108 (43) E874-E880; https://doi.org/10.1073/pnas.1110717108

• Biochemistry

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    Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain

    Michael B. Winter, Mark A. Herzik Jr., John Kuriyan, and Michael A. Marletta

    PNAS October 25, 2011 108 (43) E881-E889; https://doi.org/10.1073/pnas.1114038108
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    Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand

    • From the Cover

    James P. Hall, Kyra O’Sullivan, Abeer Naseer, Jayden A. Smith, John M. Kelly, and Christine J. Cardin

    PNAS October 25, 2011 108 (43) 17610-17614; https://doi.org/10.1073/pnas.1108685108
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    Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

    Weina Wang, Homme W. Hellinga, and Lorena S. Beese

    PNAS October 25, 2011 108 (43) 17644-17648; https://doi.org/10.1073/pnas.1114496108
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    Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity

    Aram Chang, Shanteri Singh, Kate E. Helmich, Randal D. Goff, Craig A. Bingman, Jon S. Thorson, and George N. Phillips Jr.

    PNAS October 25, 2011 108 (43) 17649-17654; https://doi.org/10.1073/pnas.1108484108
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    Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

    Luke J. Drury, Joshua J. Ziarek, Stéphanie Gravel, Christopher T. Veldkamp, Tomonori Takekoshi, Samuel T. Hwang, Nikolaus Heveker, Brian F. Volkman, and Michael B. Dwinell

    PNAS October 25, 2011 108 (43) 17655-17660; https://doi.org/10.1073/pnas.1101133108
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    Entrance of the proton pathway in cbb₃-type heme-copper oxidases

    Hyun Ju Lee, Robert B. Gennis, and Pia Ädelroth

    PNAS October 25, 2011 108 (43) 17661-17666; https://doi.org/10.1073/pnas.1107543108
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    Cap-snatching mechanism in yeast L-A double-stranded RNA virus

    Tsutomu Fujimura and Rosa Esteban

    PNAS October 25, 2011 108 (43) 17667-17671; https://doi.org/10.1073/pnas.1111900108
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    Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

    Susan E. Tsutakawa, Adam W. Van Wynsberghe, Bret D. Freudenthal, Christopher P. Weinacht, Lokesh Gakhar, M. Todd Washington, Zhihao Zhuang, John A. Tainer, and Ivaylo Ivanov

    PNAS October 25, 2011 108 (43) 17672-17677; https://doi.org/10.1073/pnas.1110480108

• Biophysics and Computational Biology

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    Locating an extracellular K⁺-dependent interaction site that modulates betaine-binding of the Na⁺-coupled betaine symporter BetP

    Lin Ge, Camilo Perez, Izabela Waclawska, Christine Ziegler, and Daniel J. Muller

    PNAS October 25, 2011 108 (43) E890-E898; https://doi.org/10.1073/pnas.1109597108
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    Quantum state and process tomography of energy transfer systems via ultrafast spectroscopy

    Joel Yuen-Zhou, Jacob J. Krich, Masoud Mohseni, and Alán Aspuru-Guzik

    PNAS October 25, 2011 108 (43) 17615-17620; https://doi.org/10.1073/pnas.1110642108
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    Extended surfaces modulate hydrophobic interactions of neighboring solutes

    Amish J. Patel, Patrick Varilly, Sumanth N. Jamadagni, Hari Acharya, Shekhar Garde, and David Chandler

    PNAS October 25, 2011 108 (43) 17678-17683; https://doi.org/10.1073/pnas.1110703108
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    Structure and function of multiple Ca²⁺-binding sites in a K⁺ channel regulator of K⁺ conductance (RCK) domain

    Victor P. T. Pau, Frank J. Smith, Alexander B. Taylor, Liubov V. Parfenova, Elsie Samakai, Matthew M. Callaghan, Karin Abarca-Heidemann, P. John Hart, and Brad S. Rothberg

    PNAS October 25, 2011 108 (43) 17684-17689; https://doi.org/10.1073/pnas.1107229108

• Cell Biology

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    Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload

    Masayuki Shimano, Noriyuki Ouchi, Kazuto Nakamura, Bram van Wijk, Koji Ohashi, Yasuhide Asaumi, Akiko Higuchi, David R. Pimentel, Flora Sam, Toyoaki Murohara, Maurice J. B. van den Hoff, and Kenneth Walsh

    PNAS October 25, 2011 108 (43) E899-E906; https://doi.org/10.1073/pnas.1108559108
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    Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process

    Leonardo Freire-de-Lima, Kirill Gelfenbeyn, Yao Ding, Ulla Mandel, Henrik Clausen, Kazuko Handa, and Sen-itiroh Hakomori

    PNAS October 25, 2011 108 (43) 17690-17695; https://doi.org/10.1073/pnas.1115191108

• Developmental Biology

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    Quiescent gastric stem cells maintain the adult Drosophila stomach

    Marie Strand and Craig A. Micchelli

    PNAS October 25, 2011 108 (43) 17696-17701; https://doi.org/10.1073/pnas.1109794108
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    Minichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppression

    Suzanne A. Hartford, Yunhai Luo, Teresa L. Southard, Irene M. Min, John T. Lis, and John C. Schimenti

    PNAS October 25, 2011 108 (43) 17702-17707; https://doi.org/10.1073/pnas.1113524108
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    Inverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegans

    Yicong Wu, Alireza Ghitani, Ryan Christensen, Anthony Santella, Zhuo Du, Gary Rondeau, Zhirong Bao, Daniel Colón-Ramos, and Hari Shroff

    PNAS October 25, 2011 108 (43) 17708-17713; https://doi.org/10.1073/pnas.1108494108

• Ecology

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    Identifying critical regions in small-world marine metapopulations

    James R. Watson, David A. Siegel, Bruce E. Kendall, Satoshi Mitarai, Andrew Rassweiller, and Steven D. Gaines

    PNAS October 25, 2011 108 (43) E907-E913; https://doi.org/10.1073/pnas.1111461108
  • Open Access

    Temporal clustering of tropical cyclones and its ecosystem impacts

    Peter J. Mumby, Renato Vitolo, and David B. Stephenson

    PNAS October 25, 2011 108 (43) 17626-17630; https://doi.org/10.1073/pnas.1100436108
  • Open Access

    Evidence of cellulose metabolism by the giant panda gut microbiome

    Lifeng Zhu, Qi Wu, Jiayin Dai, Shanning Zhang, and Fuwen Wei

    PNAS October 25, 2011 108 (43) 17714-17719; https://doi.org/10.1073/pnas.1017956108
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    Molecular study of worldwide distribution and diversity of soil animals

    Tiehang Wu, Edward Ayres, Richard D. Bardgett, Diana H. Wall, and James R. Garey

    PNAS October 25, 2011 108 (43) 17720-17725; https://doi.org/10.1073/pnas.1103824108
  • Open Access

    Macroalgal terpenes function as allelopathic agents against reef corals

    Douglas B. Rasher, E. Paige Stout, Sebastian Engel, Julia Kubanek, and Mark E. Hay

    PNAS October 25, 2011 108 (43) 17726-17731; https://doi.org/10.1073/pnas.1108628108

• Environmental Sciences

  • Open Access

    Effects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryos

    Eunah Chung, Maria C. Genco, Laura Megrelis, and Joan V. Ruderman

    PNAS October 25, 2011 108 (43) 17732-17737; https://doi.org/10.1073/pnas.1115187108

• Evolution

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    Ancient host specificity within a single species of brood parasitic bird

    • From the Cover

    Claire N. Spottiswoode, Katherine Faust Stryjewski, Suhel Quader, John F. R. Colebrook-Robjent, and Michael D. Sorenson

    PNAS October 25, 2011 108 (43) 17738-17742; https://doi.org/10.1073/pnas.1109630108
  • Open Access

    Sexual selection by female immunity against paternal antigens can fix loss of function alleles

    Darius Ghaderi, Stevan A. Springer, Fang Ma, Miriam Cohen, Patrick Secrest, Rachel E. Taylor, Ajit Varki, and Pascal Gagneux

    PNAS October 25, 2011 108 (43) 17743-17748; https://doi.org/10.1073/pnas.1102302108

• Genetics

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    Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability

    Hery Ratsima, Anne-Marie Ladouceur, Mirela Pascariu, Véronique Sauvé, Zeina Salloum, Paul S. Maddox, and Damien D'Amours

    PNAS October 25, 2011 108 (43) E914-E923; https://doi.org/10.1073/pnas.1106448108
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    Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF

    Erez Feige, Satoru Yokoyama, Carmit Levy, Mehdi Khaled, Vivien Igras, Richard J. Lin, Stephen Lee, Hans R. Widlund, Scott R. Granter, Andrew L. Kung, and David E. Fisher

    PNAS October 25, 2011 108 (43) E924-E933; https://doi.org/10.1073/pnas.1106351108

• Immunology

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    Requirement for complement in antibody responses is not explained by the classic pathway activator IgM

    Christian Rutemark, Elisabeth Alicot, Anna Bergman, Minghe Ma, Andrew Getahun, Stephan Ellmerich, Michael C. Carroll, and Birgitta Heyman

    PNAS October 25, 2011 108 (43) E934-E942; https://doi.org/10.1073/pnas.1109831108
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    A role for c-Myc in regulating anti-mycobacterial responses

    Howard C. H. Yim, James C. B. Li, John C. H. Pong, and Allan S. Y. Lau

    PNAS October 25, 2011 108 (43) 17749-17754; https://doi.org/10.1073/pnas.1104892108
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    Structural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipids

    Luis F. Garcia-Alles, Anthony Collmann, Cees Versluis, Buko Lindner, Julie Guiard, Laurent Maveyraud, Emilie Huc, Jin S. Im, Sebastiano Sansano, Thérèse Brando, Sylviane Julien, Jacques Prandi, Martine Gilleron, Steven A. Porcelli, Henri de la Salle, Albert J. R. Heck, Lucia Mori, Germain Puzo, Lionel Mourey, and Gennaro De Libero

    PNAS October 25, 2011 108 (43) 17755-17760; https://doi.org/10.1073/pnas.1110118108

• Medical Sciences

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    A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis

    Nicholas Dompe, Celina Sanchez Rivers, Li Li, Shaun Cordes, Martin Schwickart, Elizabeth A. Punnoose, Lukas Amler, Somasekar Seshagiri, Jerry Tang, Zora Modrusan, and David P. Davis

    PNAS October 25, 2011 108 (43) E943-E951; https://doi.org/10.1073/pnas.1100132108
  • Open Access

    Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

    Nicholas J. Wang, Zachary Sanborn, Kelly L. Arnett, Laura J. Bayston, Wilson Liao, Charlotte M. Proby, Irene M. Leigh, Eric A. Collisson, Patricia B. Gordon, Lakshmi Jakkula, Sally Pennypacker, Yong Zou, Mimansa Sharma, Jeffrey P. North, Swapna S. Vemula, Theodora M. Mauro, Isaac M. Neuhaus, Philip E. LeBoit, Joe S. Hur, Kyunghee Park, Nam Huh, Pui-Yan Kwok, Sarah T. Arron, Pierre P. Massion, Allen E. Bale, David Haussler, James E. Cleaver, Joe W. Gray, Paul T. Spellman, Andrew P. South, Jon C. Aster, Stephen C. Blacklow, and Raymond J. Cho

    PNAS October 25, 2011 108 (43) 17761-17766; https://doi.org/10.1073/pnas.1114669108
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    Sympathetic control of bone mass regulated by osteopontin

    Masashi Nagao, Timothy N. Feinstein, Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Yoshitomo Saita, Ryo Hanyu, Hiroaki Hemmi, Yayoi Izu, Shu Takeda, Kathryn Wang, Susan Rittling, Tetsuya Nakamoto, Kazuo Kaneko, Hisashi Kurosawa, Gerard Karsenty, David T. Denhardt, Jean-Pierre Vilardaga, and Masaki Noda

    PNAS October 25, 2011 108 (43) 17767-17772; https://doi.org/10.1073/pnas.1109402108
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    Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells

    Hiroyuki Konishi, Morassa Mohseni, Akina Tamaki, Joseph P. Garay, Sarah Croessmann, Sivasundaram Karnan, Akinobu Ota, Hong Yuen Wong, Yuko Konishi, Bedri Karakas, Khola Tahir, Abde M. Abukhdeir, John P. Gustin, Justin Cidado, Grace M. Wang, David Cosgrove, Rory Cochran, Danijela Jelovac, Michaela J. Higgins, Sabrina Arena, Lauren Hawkins, Josh Lauring, Amy L. Gross, Christopher M. Heaphy, Yositaka Hosokawa, Edward Gabrielson, Alan K. Meeker, Kala Visvanathan, Pedram Argani, Kurtis E. Bachman, and Ben Ho Park

    PNAS October 25, 2011 108 (43) 17773-17778; https://doi.org/10.1073/pnas.1110969108
  • Open Access

    Antitumorigenic potential of STAT3 alternative splicing modulation

    Francesca Zammarchi, Elisa de Stanchina, Eirini Bournazou, Teerawit Supakorndej, Kathryn Martires, Elyn Riedel, Adriana D. Corben, Jacqueline F. Bromberg, and Luca Cartegni

    PNAS October 25, 2011 108 (43) 17779-17784; https://doi.org/10.1073/pnas.1108482108

• Microbiology

  • Open Access

    Transcriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilus

    Joakim M. Andersen, Rodolphe Barrangou, Maher Abou Hachem, Sampo Lahtinen, Yong Jun Goh, Birte Svensson, and Todd R. Klaenhammer

    PNAS October 25, 2011 108 (43) 17785-17790; https://doi.org/10.1073/pnas.1114152108
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    Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase

    Yin Chen, Nisha A. Patel, Andrew Crombie, James H. Scrivens, and J. Colin Murrell

    PNAS October 25, 2011 108 (43) 17791-17796; https://doi.org/10.1073/pnas.1112928108

• Neuroscience

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    Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

    Bogdan Beirowski, Jason Gustin, Sean M. Armour, Hiroyasu Yamamoto, Andreu Viader, Brian J. North, Shaday Michán, Robert H. Baloh, Judy P. Golden, Robert E. Schmidt, David A. Sinclair, Johan Auwerx, and Jeffrey Milbrandt

    PNAS October 25, 2011 108 (43) E952-E961; https://doi.org/10.1073/pnas.1104969108
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    Dysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia

    • From the Cover

    Gregory C. Carlson, Konrad Talbot, Tobias B. Halene, Michael J. Gandal, Hala A. Kazi, Laura Schlosser, Quan H. Phung, Raquel E. Gur, Steven E. Arnold, and Steven J. Siegel

    PNAS October 25, 2011 108 (43) E962-E970; https://doi.org/10.1073/pnas.1109625108
  • Open Access

    A soluble α-synuclein construct forms a dynamic tetramer

    Wei Wang, Iva Perovic, Johnathan Chittuluru, Alice Kaganovich, Linh T. T. Nguyen, Jingling Liao, Jared R. Auclair, Derrick Johnson, Anuradha Landeru, Alana K. Simorellis, Shulin Ju, Mark R. Cookson, Francisco J. Asturias, Jeffrey N. Agar, Brian N. Webb, ChulHee Kang, Dagmar Ringe, Gregory A. Petsko, Thomas C. Pochapsky, and Quyen Q. Hoang

    PNAS October 25, 2011 108 (43) 17797-17802; https://doi.org/10.1073/pnas.1113260108
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    Astrocytes carrying the superoxide dismutase 1 (SOD1^G93A) mutation induce wild-type motor neuron degeneration in vivo

    Sophia T. Papadeas, Sarah E. Kraig, Colin O'Banion, Angelo C. Lepore, and Nicholas J. Maragakis

    PNAS October 25, 2011 108 (43) 17803-17808; https://doi.org/10.1073/pnas.1103141108
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    New methods devised specify the size and color of the spots monkeys see when striate cortex (area V1) is electrically stimulated

    • From the Cover

    Peter H. Schiller, Warren M. Slocum, Michelle C. Kwak, Geoffrey L. Kendall, and Edward J. Tehovnik

    PNAS October 25, 2011 108 (43) 17809-17814; https://doi.org/10.1073/pnas.1108337108
  • Open Access

    Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood–brain water uptake and confers barrier function on perivascular astrocyte endfeet

    Nadia Nabil Haj-Yasein, Gry Fluge Vindedal, Martine Eilert-Olsen, Georg Andreas Gundersen, Øivind Skare, Petter Laake, Arne Klungland, Anna Elisabeth Thorén, John Michael Burkhardt, Ole Petter Ottersen, and Erlend Arnulf Nagelhus

    PNAS October 25, 2011 108 (43) 17815-17820; https://doi.org/10.1073/pnas.1110655108
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    Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network

    Guang-Hua Peng and Shiming Chen

    PNAS October 25, 2011 108 (43) 17821-17826; https://doi.org/10.1073/pnas.1109209108
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    Oxygen modulation of neurovascular coupling in the retina

    Anusha Mishra, Arif Hamid, and Eric A. Newman

    PNAS October 25, 2011 108 (43) 17827-17831; https://doi.org/10.1073/pnas.1110533108

• Physiology

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    Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states

    Angelo Demuro, Aubin Penna, Olga Safrina, Andriy V. Yeromin, Anna Amcheslavsky, Michael D. Cahalan, and Ian Parker

    PNAS October 25, 2011 108 (43) 17832-17837; https://doi.org/10.1073/pnas.1114814108
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    Mutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91

    Shenyuan L. Zhang, Andriy V. Yeromin, Junjie Hu, Anna Amcheslavsky, Hongying Zheng, and Michael D. Cahalan

    PNAS October 25, 2011 108 (43) 17838-17843; https://doi.org/10.1073/pnas.1114821108

• Plant Biology

  • Open Access

    Phosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plants

    Michiko Sasabe, Véronique Boudolf, Lieven De Veylder, Dirk Inzé, Pascal Genschik, and Yasunori Machida

    PNAS October 25, 2011 108 (43) 17844-17849; https://doi.org/10.1073/pnas.1110174108
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    Clusters of bioactive compounds target dynamic endomembrane networks in vivo

    Georgia Drakakaki, Stéphanie Robert, Anna-Maria Szatmari, Michelle Q. Brown, Shingo Nagawa, Daniel Van Damme, Marilyn Leonard, Zhenbiao Yang, Thomas Girke, Sandra L. Schmid, Eugenia Russinova, Jiří Friml, Natasha V. Raikhel, and Glenn R. Hicks

    PNAS October 25, 2011 108 (43) 17850-17855; https://doi.org/10.1073/pnas.1108581108

• Psychological and Cognitive Sciences

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    Comparing machines and humans on a visual categorization test

    François Fleuret, Ting Li, Charles Dubout, Emma K. Wampler, Steven Yantis, and Donald Geman

    PNAS October 25, 2011 108 (43) 17621-17625; https://doi.org/10.1073/pnas.1109168108