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Table of Contents
October 25, 2011; vol. 108 no. 43
This Week in PNAS
Letters (Online Only)
- You have accessMethane contamination of drinking water caused by hydraulic fracturing remains unprovenRichard J. Davies
- You have accessReply to Davies: Hydraulic fracturing remains a possible mechanism for observed methane contamination of drinking waterRobert B. Jackson, Stephen G. Osborn, Avner Vengosh, and Nathaniel R. Warner
- You have accessReply to Sharp et al.: Host species sampling bias and Plasmodium falciparum origin paradigm shiftsFranck Prugnolle, Patrick Durand, Benjamin Ollomo, Francisco J. Ayala, and François Renaud
PNAS Plus (Author Summaries and Research Articles)
Social Sciences – Sustainability Science – Biological Sciences – Ecology
- You have accessIdentifying critical regions in small-world marine metapopulationsJames R. Watson, David A. Siegel, Bruce E. Kendall, Satoshi Mitarai, Andrew Rassweiller, and Steven D. Gaines
Biological Sciences
Applied Biological Sciences
- Open AccessRequirements for effective malaria control with homing endonuclease genesAnne Deredec, H. Charles J. Godfray, and Austin Burt
Biochemistry
- You have accessTunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domainMichael B. Winter, Mark A. Herzik Jr., John Kuriyan, and Michael A. Marletta
Biophysics and Computational Biology
- You have accessLocating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetPLin Ge, Camilo Perez, Izabela Waclawska, Christine Ziegler, and Daniel J. Muller
Cell Biology
- You have accessCardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overloadMasayuki Shimano, Noriyuki Ouchi, Kazuto Nakamura, Bram van Wijk, Koji Ohashi, Yasuhide Asaumi, Akiko Higuchi, David R. Pimentel, Flora Sam, Toyoaki Murohara, Maurice J. B. van den Hoff, and Kenneth Walsh
Genetics
- You have accessIndependent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stabilityHery Ratsima, Anne-Marie Ladouceur, Mirela Pascariu, Véronique Sauvé, Zeina Salloum, Paul S. Maddox, and Damien D'Amours
- You have accessHypoxia-induced transcriptional repression of the melanoma-associated oncogene MITFErez Feige, Satoru Yokoyama, Carmit Levy, Mehdi Khaled, Vivien Igras, Richard J. Lin, Stephen Lee, Hans R. Widlund, Scott R. Granter, Andrew L. Kung, and David E. Fisher
Immunology
- You have accessRequirement for complement in antibody responses is not explained by the classic pathway activator IgMChristian Rutemark, Elisabeth Alicot, Anna Bergman, Minghe Ma, Andrew Getahun, Stephan Ellmerich, Michael C. Carroll, and Birgitta Heyman
Medical Sciences
- You have accessA whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosisNicholas Dompe, Celina Sanchez Rivers, Li Li, Shaun Cordes, Martin Schwickart, Elizabeth A. Punnoose, Lukas Amler, Somasekar Seshagiri, Jerry Tang, Zora Modrusan, and David P. Davis
Neuroscience
- You have accessSir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signalingBogdan Beirowski, Jason Gustin, Sean M. Armour, Hiroyasu Yamamoto, Andreu Viader, Brian J. North, Shaday Michán, Robert H. Baloh, Judy P. Golden, Robert E. Schmidt, David A. Sinclair, Johan Auwerx, and Jeffrey Milbrandt
- You have accessDysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
- From the Cover
Gregory C. Carlson, Konrad Talbot, Tobias B. Halene, Michael J. Gandal, Hala A. Kazi, Laura Schlosser, Quan H. Phung, Raquel E. Gur, Steven E. Arnold, and Steven J. Siegel
Retrospective
- You have accessEdward (Ted) G. Jones, a neuroscientist and prolific neuroanatomistWilliam E. Bunney
Physical Sciences
Applied Physical Sciences
- Open AccessCompact and flexible raster scanning multiphoton endoscope capable of imaging unstained tissueDavid R. Rivera, Christopher M. Brown, Dimitre G. Ouzounov, Ina Pavlova, Demirhan Kobat, Watt W. Webb, and Chris Xu
Astronomy
- You have accessFast accretion of the Earth with a late Moon-forming giant impactGang Yu and Stein B. Jacobsen
Chemistry
- You have accessStructure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand
- From the Cover
James P. Hall, Kyra O’Sullivan, Abeer Naseer, Jayden A. Smith, John M. Kelly, and Christine J. CardinSee companion article:
- To intercalate or semiintercalate, or both?- Oct 13, 2011
- You have accessQuantum state and process tomography of energy transfer systems via ultrafast spectroscopyJoel Yuen-Zhou, Jacob J. Krich, Masoud Mohseni, and Alán Aspuru-Guzik
- You have accessExtended surfaces modulate hydrophobic interactions of neighboring solutesAmish J. Patel, Patrick Varilly, Sumanth N. Jamadagni, Hari Acharya, Shekhar Garde, and David Chandler
Computer Sciences
- You have accessComparing machines and humans on a visual categorization testFrançois Fleuret, Ting Li, Charles Dubout, Emma K. Wampler, Steven Yantis, and Donald Geman
Environmental Sciences
- Open AccessTemporal clustering of tropical cyclones and its ecosystem impactsPeter J. Mumby, Renato Vitolo, and David B. Stephenson
Geology
- You have accessRapid expansion of oceanic anoxia immediately before the end-Permian mass extinction
- From the Cover
Gregory A. Brennecka, Achim D. Herrmann, Thomas J. Algeo, and Ariel D. Anbar
Geophysics
- You have accessEvidence of magnetic isotope effects during thermochemical sulfate reductionHarry Oduro, Brian Harms, Herman O. Sintim, Alan J. Kaufman, George Cody, and James Farquhar
- You have accessEarly Archean serpentine mud volcanoes at Isua, Greenland, as a niche for early lifeMarie-Laure Pons, Ghylaine Quitté, Toshiyuki Fujii, Minik T. Rosing, Bruno Reynard, Frederic Moynier, Chantal Douchet, and Francis Albarède
Social Sciences
Sustainability Science
- You have accessIdentifying critical regions in small-world marine metapopulationsJames R. Watson, David A. Siegel, Bruce E. Kendall, Satoshi Mitarai, Andrew Rassweiller, and Steven D. Gaines
Biological Sciences
Applied Biological Sciences
- Open AccessRequirements for effective malaria control with homing endonuclease genesAnne Deredec, H. Charles J. Godfray, and Austin Burt
Biochemistry
- You have accessTunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domainMichael B. Winter, Mark A. Herzik Jr., John Kuriyan, and Michael A. Marletta
- You have accessStructure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand
- From the Cover
James P. Hall, Kyra O’Sullivan, Abeer Naseer, Jayden A. Smith, John M. Kelly, and Christine J. CardinSee companion article:
- To intercalate or semiintercalate, or both?- Oct 13, 2011
- You have accessStructural evidence for the rare tautomer hypothesis of spontaneous mutagenesisWeina Wang, Homme W. Hellinga, and Lorena S. Beese
- You have accessComplete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificityAram Chang, Shanteri Singh, Kate E. Helmich, Randal D. Goff, Craig A. Bingman, Jon S. Thorson, and George N. Phillips Jr.
- You have accessMonomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathwaysLuke J. Drury, Joshua J. Ziarek, Stéphanie Gravel, Christopher T. Veldkamp, Tomonori Takekoshi, Samuel T. Hwang, Nikolaus Heveker, Brian F. Volkman, and Michael B. Dwinell
- You have accessEntrance of the proton pathway in cbb3-type heme-copper oxidasesHyun Ju Lee, Robert B. Gennis, and Pia Ädelroth
- You have accessCap-snatching mechanism in yeast L-A double-stranded RNA virusTsutomu Fujimura and Rosa Esteban
- You have accessSolution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNASusan E. Tsutakawa, Adam W. Van Wynsberghe, Bret D. Freudenthal, Christopher P. Weinacht, Lokesh Gakhar, M. Todd Washington, Zhihao Zhuang, John A. Tainer, and Ivaylo Ivanov
Biophysics and Computational Biology
- You have accessLocating an extracellular K+-dependent interaction site that modulates betaine-binding of the Na+-coupled betaine symporter BetPLin Ge, Camilo Perez, Izabela Waclawska, Christine Ziegler, and Daniel J. Muller
- You have accessQuantum state and process tomography of energy transfer systems via ultrafast spectroscopyJoel Yuen-Zhou, Jacob J. Krich, Masoud Mohseni, and Alán Aspuru-Guzik
- You have accessExtended surfaces modulate hydrophobic interactions of neighboring solutesAmish J. Patel, Patrick Varilly, Sumanth N. Jamadagni, Hari Acharya, Shekhar Garde, and David Chandler
- You have accessStructure and function of multiple Ca2+-binding sites in a K+ channel regulator of K+ conductance (RCK) domainVictor P. T. Pau, Frank J. Smith, Alexander B. Taylor, Liubov V. Parfenova, Elsie Samakai, Matthew M. Callaghan, Karin Abarca-Heidemann, P. John Hart, and Brad S. Rothberg
Cell Biology
- You have accessCardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overloadMasayuki Shimano, Noriyuki Ouchi, Kazuto Nakamura, Bram van Wijk, Koji Ohashi, Yasuhide Asaumi, Akiko Higuchi, David R. Pimentel, Flora Sam, Toyoaki Murohara, Maurice J. B. van den Hoff, and Kenneth Walsh
- You have accessInvolvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition processLeonardo Freire-de-Lima, Kirill Gelfenbeyn, Yao Ding, Ulla Mandel, Henrik Clausen, Kazuko Handa, and Sen-itiroh Hakomori
Developmental Biology
- You have accessQuiescent gastric stem cells maintain the adult Drosophila stomachMarie Strand and Craig A. Micchelli
- You have accessMinichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppressionSuzanne A. Hartford, Yunhai Luo, Teresa L. Southard, Irene M. Min, John T. Lis, and John C. Schimenti
- You have accessInverted selective plane illumination microscopy (iSPIM) enables coupled cell identity lineaging and neurodevelopmental imaging in Caenorhabditis elegansYicong Wu, Alireza Ghitani, Ryan Christensen, Anthony Santella, Zhuo Du, Gary Rondeau, Zhirong Bao, Daniel Colón-Ramos, and Hari Shroff
Ecology
- You have accessIdentifying critical regions in small-world marine metapopulationsJames R. Watson, David A. Siegel, Bruce E. Kendall, Satoshi Mitarai, Andrew Rassweiller, and Steven D. Gaines
- Open AccessTemporal clustering of tropical cyclones and its ecosystem impactsPeter J. Mumby, Renato Vitolo, and David B. Stephenson
- Open AccessEvidence of cellulose metabolism by the giant panda gut microbiomeLifeng Zhu, Qi Wu, Jiayin Dai, Shanning Zhang, and Fuwen Wei
- You have accessMolecular study of worldwide distribution and diversity of soil animalsTiehang Wu, Edward Ayres, Richard D. Bardgett, Diana H. Wall, and James R. Garey
- Open AccessMacroalgal terpenes function as allelopathic agents against reef coralsDouglas B. Rasher, E. Paige Stout, Sebastian Engel, Julia Kubanek, and Mark E. Hay
Environmental Sciences
- Open AccessEffects of bisphenol A and triclocarban on brain-specific expression of aromatase in early zebrafish embryosEunah Chung, Maria C. Genco, Laura Megrelis, and Joan V. Ruderman
Evolution
- You have accessAncient host specificity within a single species of brood parasitic bird
- From the Cover
Claire N. Spottiswoode, Katherine Faust Stryjewski, Suhel Quader, John F. R. Colebrook-Robjent, and Michael D. SorensonSee companion article:
- Open AccessSexual selection by female immunity against paternal antigens can fix loss of function allelesDarius Ghaderi, Stevan A. Springer, Fang Ma, Miriam Cohen, Patrick Secrest, Rachel E. Taylor, Ajit Varki, and Pascal Gagneux
Genetics
- You have accessIndependent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stabilityHery Ratsima, Anne-Marie Ladouceur, Mirela Pascariu, Véronique Sauvé, Zeina Salloum, Paul S. Maddox, and Damien D'Amours
- You have accessHypoxia-induced transcriptional repression of the melanoma-associated oncogene MITFErez Feige, Satoru Yokoyama, Carmit Levy, Mehdi Khaled, Vivien Igras, Richard J. Lin, Stephen Lee, Hans R. Widlund, Scott R. Granter, Andrew L. Kung, and David E. Fisher
Immunology
- You have accessRequirement for complement in antibody responses is not explained by the classic pathway activator IgMChristian Rutemark, Elisabeth Alicot, Anna Bergman, Minghe Ma, Andrew Getahun, Stephan Ellmerich, Michael C. Carroll, and Birgitta Heyman
- You have accessA role for c-Myc in regulating anti-mycobacterial responsesHoward C. H. Yim, James C. B. Li, John C. H. Pong, and Allan S. Y. Lau
- You have accessStructural reorganization of the antigen-binding groove of human CD1b for presentation of mycobacterial sulfoglycolipidsLuis F. Garcia-Alles, Anthony Collmann, Cees Versluis, Buko Lindner, Julie Guiard, Laurent Maveyraud, Emilie Huc, Jin S. Im, Sebastiano Sansano, Thérèse Brando, Sylviane Julien, Jacques Prandi, Martine Gilleron, Steven A. Porcelli, Henri de la Salle, Albert J. R. Heck, Lucia Mori, Germain Puzo, Lionel Mourey, and Gennaro De Libero
Medical Sciences
- You have accessA whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosisNicholas Dompe, Celina Sanchez Rivers, Li Li, Shaun Cordes, Martin Schwickart, Elizabeth A. Punnoose, Lukas Amler, Somasekar Seshagiri, Jerry Tang, Zora Modrusan, and David P. Davis
- Open AccessLoss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinomaNicholas J. Wang, Zachary Sanborn, Kelly L. Arnett, Laura J. Bayston, Wilson Liao, Charlotte M. Proby, Irene M. Leigh, Eric A. Collisson, Patricia B. Gordon, Lakshmi Jakkula, Sally Pennypacker, Yong Zou, Mimansa Sharma, Jeffrey P. North, Swapna S. Vemula, Theodora M. Mauro, Isaac M. Neuhaus, Philip E. LeBoit, Joe S. Hur, Kyunghee Park, Nam Huh, Pui-Yan Kwok, Sarah T. Arron, Pierre P. Massion, Allen E. Bale, David Haussler, James E. Cleaver, Joe W. Gray, Paul T. Spellman, Andrew P. South, Jon C. Aster, Stephen C. Blacklow, and Raymond J. Cho
- You have accessSympathetic control of bone mass regulated by osteopontinMasashi Nagao, Timothy N. Feinstein, Yoichi Ezura, Tadayoshi Hayata, Takuya Notomi, Yoshitomo Saita, Ryo Hanyu, Hiroaki Hemmi, Yayoi Izu, Shu Takeda, Kathryn Wang, Susan Rittling, Tetsuya Nakamoto, Kazuo Kaneko, Hisashi Kurosawa, Gerard Karsenty, David T. Denhardt, Jean-Pierre Vilardaga, and Masaki Noda
- You have accessMutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cellsHiroyuki Konishi, Morassa Mohseni, Akina Tamaki, Joseph P. Garay, Sarah Croessmann, Sivasundaram Karnan, Akinobu Ota, Hong Yuen Wong, Yuko Konishi, Bedri Karakas, Khola Tahir, Abde M. Abukhdeir, John P. Gustin, Justin Cidado, Grace M. Wang, David Cosgrove, Rory Cochran, Danijela Jelovac, Michaela J. Higgins, Sabrina Arena, Lauren Hawkins, Josh Lauring, Amy L. Gross, Christopher M. Heaphy, Yositaka Hosokawa, Edward Gabrielson, Alan K. Meeker, Kala Visvanathan, Pedram Argani, Kurtis E. Bachman, and Ben Ho Park
- Open AccessAntitumorigenic potential of STAT3 alternative splicing modulationFrancesca Zammarchi, Elisa de Stanchina, Eirini Bournazou, Teerawit Supakorndej, Kathryn Martires, Elyn Riedel, Adriana D. Corben, Jacqueline F. Bromberg, and Luca Cartegni
Microbiology
- Open AccessTranscriptional and functional analysis of galactooligosaccharide uptake by lacS in Lactobacillus acidophilusJoakim M. Andersen, Rodolphe Barrangou, Maher Abou Hachem, Sampo Lahtinen, Yong Jun Goh, Birte Svensson, and Todd R. Klaenhammer
- You have accessBacterial flavin-containing monooxygenase is trimethylamine monooxygenaseYin Chen, Nisha A. Patel, Andrew Crombie, James H. Scrivens, and J. Colin Murrell
Neuroscience
- You have accessSir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signalingBogdan Beirowski, Jason Gustin, Sean M. Armour, Hiroyasu Yamamoto, Andreu Viader, Brian J. North, Shaday Michán, Robert H. Baloh, Judy P. Golden, Robert E. Schmidt, David A. Sinclair, Johan Auwerx, and Jeffrey Milbrandt
- You have accessDysbindin-1 mutant mice implicate reduced fast-phasic inhibition as a final common disease mechanism in schizophrenia
- From the Cover
Gregory C. Carlson, Konrad Talbot, Tobias B. Halene, Michael J. Gandal, Hala A. Kazi, Laura Schlosser, Quan H. Phung, Raquel E. Gur, Steven E. Arnold, and Steven J. Siegel - Open AccessA soluble α-synuclein construct forms a dynamic tetramerWei Wang, Iva Perovic, Johnathan Chittuluru, Alice Kaganovich, Linh T. T. Nguyen, Jingling Liao, Jared R. Auclair, Derrick Johnson, Anuradha Landeru, Alana K. Simorellis, Shulin Ju, Mark R. Cookson, Francisco J. Asturias, Jeffrey N. Agar, Brian N. Webb, ChulHee Kang, Dagmar Ringe, Gregory A. Petsko, Thomas C. Pochapsky, and Quyen Q. Hoang
- You have accessAstrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivoSophia T. Papadeas, Sarah E. Kraig, Colin O'Banion, Angelo C. Lepore, and Nicholas J. Maragakis
- You have accessNew methods devised specify the size and color of the spots monkeys see when striate cortex (area V1) is electrically stimulated
- From the Cover
Peter H. Schiller, Warren M. Slocum, Michelle C. Kwak, Geoffrey L. Kendall, and Edward J. Tehovnik - Open AccessGlial-conditional deletion of aquaporin-4 (Aqp4) reduces blood–brain water uptake and confers barrier function on perivascular astrocyte endfeetNadia Nabil Haj-Yasein, Gry Fluge Vindedal, Martine Eilert-Olsen, Georg Andreas Gundersen, Øivind Skare, Petter Laake, Arne Klungland, Anna Elisabeth Thorén, John Michael Burkhardt, Ole Petter Ottersen, and Erlend Arnulf Nagelhus
- You have accessActive opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor networkGuang-Hua Peng and Shiming Chen
- You have accessOxygen modulation of neurovascular coupling in the retinaAnusha Mishra, Arif Hamid, and Eric A. Newman
Physiology
- You have accessSubunit stoichiometry of human Orai1 and Orai3 channels in closed and open statesAngelo Demuro, Aubin Penna, Olga Safrina, Andriy V. Yeromin, Anna Amcheslavsky, Michael D. Cahalan, and Ian Parker
- You have accessMutations in Orai1 transmembrane segment 1 cause STIM1-independent activation of Orai1 channels at glycine 98 and channel closure at arginine 91Shenyuan L. Zhang, Andriy V. Yeromin, Junjie Hu, Anna Amcheslavsky, Hongying Zheng, and Michael D. Cahalan
Plant Biology
- Open AccessPhosphorylation of a mitotic kinesin-like protein and a MAPKKK by cyclin-dependent kinases (CDKs) is involved in the transition to cytokinesis in plantsMichiko Sasabe, Véronique Boudolf, Lieven De Veylder, Dirk Inzé, Pascal Genschik, and Yasunori Machida
- You have accessClusters of bioactive compounds target dynamic endomembrane networks in vivoGeorgia Drakakaki, Stéphanie Robert, Anna-Maria Szatmari, Michelle Q. Brown, Shingo Nagawa, Daniel Van Damme, Marilyn Leonard, Zhenbiao Yang, Thomas Girke, Sandra L. Schmid, Eugenia Russinova, Jiří Friml, Natasha V. Raikhel, and Glenn R. Hicks
Psychological and Cognitive Sciences
- You have accessComparing machines and humans on a visual categorization testFrançois Fleuret, Ting Li, Charles Dubout, Emma K. Wampler, Steven Yantis, and Donald Geman
Commentary
See companion article: